GTF2IP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.98220658
2sperm motility (GO:0030317)9.49087096
3spermatid nucleus differentiation (GO:0007289)8.38268663
4fusion of sperm to egg plasma membrane (GO:0007342)7.79769745
5response to pheromone (GO:0019236)7.55728696
6single strand break repair (GO:0000012)7.18941532
7protein polyglutamylation (GO:0018095)6.79086739
8sperm capacitation (GO:0048240)6.75568485
9DNA packaging (GO:0006323)6.71341534
10chromosome condensation (GO:0030261)6.62637406
11spermatid development (GO:0007286)6.61124617
12microtubule depolymerization (GO:0007019)6.31105754
13sperm-egg recognition (GO:0035036)6.29602687
14reproduction (GO:0000003)6.26037566
15multicellular organism reproduction (GO:0032504)6.23022322
16protein targeting to Golgi (GO:0000042)6.09755285
17binding of sperm to zona pellucida (GO:0007339)6.06113536
18plasma membrane fusion (GO:0045026)5.93735208
19establishment of protein localization to Golgi (GO:0072600)5.88761151
20sexual reproduction (GO:0019953)5.84005704
21retrograde transport, vesicle recycling within Golgi (GO:0000301)5.68744710
22seminiferous tubule development (GO:0072520)5.52213186
23rRNA methylation (GO:0031167)5.27729584
24cell-cell recognition (GO:0009988)5.18586111
25multicellular organismal movement (GO:0050879)5.12803771
26musculoskeletal movement (GO:0050881)5.12803771
27calcium ion-dependent exocytosis (GO:0017156)5.05953660
28centriole replication (GO:0007099)5.05628695
29epithelial cilium movement (GO:0003351)4.91288725
30microtubule polymerization or depolymerization (GO:0031109)4.89055076
31cilium or flagellum-dependent cell motility (GO:0001539)4.87273374
32segment specification (GO:0007379)4.85535922
33regulation of cilium movement (GO:0003352)4.80947228
34axonemal dynein complex assembly (GO:0070286)4.80559249
35phosphatidylethanolamine biosynthetic process (GO:0006646)4.73540653
36mitotic G1 DNA damage checkpoint (GO:0031571)4.63424900
37spermatogenesis (GO:0007283)4.55755228
38male gamete generation (GO:0048232)4.55311039
39single fertilization (GO:0007338)4.52594046
40protein localization to Golgi apparatus (GO:0034067)4.48782762
41motile cilium assembly (GO:0044458)4.41151139
42G1 DNA damage checkpoint (GO:0044783)4.34901644
43phosphatidylethanolamine metabolic process (GO:0046337)4.33442712
44rRNA modification (GO:0000154)4.30968899
45centriole assembly (GO:0098534)4.29462618
46gamete generation (GO:0007276)4.21513709
47microtubule severing (GO:0051013)4.19303467
48mitotic G1/S transition checkpoint (GO:0044819)4.05193492
49RNA destabilization (GO:0050779)4.04753427
50negative regulation of inclusion body assembly (GO:0090084)4.00777304
51regulation of Rab GTPase activity (GO:0032313)3.91990381
52positive regulation of Rab GTPase activity (GO:0032851)3.91990381
53fertilization (GO:0009566)3.90963001
54cellular ketone body metabolic process (GO:0046950)3.84326775
55male meiosis I (GO:0007141)3.75489279
56cilium movement (GO:0003341)3.75446242
57germ cell development (GO:0007281)3.66240152
58regulation of centriole replication (GO:0046599)3.66043602
59piRNA metabolic process (GO:0034587)3.65409800
60nucleus organization (GO:0006997)3.60800104
61DNA topological change (GO:0006265)3.53107636
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.45996575
63glycerol ether metabolic process (GO:0006662)3.42485733
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.41945092
65multicellular organismal reproductive process (GO:0048609)3.38211027
66ketone body metabolic process (GO:1902224)3.37992247
67intra-Golgi vesicle-mediated transport (GO:0006891)3.36092697
68polyamine biosynthetic process (GO:0006596)3.32968477
69chromatin silencing (GO:0006342)3.32435155
70cerebral cortex neuron differentiation (GO:0021895)3.29008323
71organic cation transport (GO:0015695)3.27672267
72negative regulation of oligodendrocyte differentiation (GO:0048715)3.27097929
73homeostasis of number of cells within a tissue (GO:0048873)3.24628951
74regulation of transcription involved in cell fate commitment (GO:0060850)3.18698392
75ether metabolic process (GO:0018904)3.13337949
76histone H3-K9 methylation (GO:0051567)3.10202181
77axoneme assembly (GO:0035082)3.06221435
78nucleosome disassembly (GO:0006337)3.02002795
79protein-DNA complex disassembly (GO:0032986)3.02002795
80DNA conformation change (GO:0071103)3.01566644
81behavioral response to nicotine (GO:0035095)2.95958988
82meiosis I (GO:0007127)2.95923933
83regulation of telomere maintenance (GO:0032204)2.93917163
84regulation of inclusion body assembly (GO:0090083)2.92439937
85cell wall macromolecule metabolic process (GO:0044036)2.92021157
86positive regulation of mitochondrial fission (GO:0090141)2.90736049
87T cell migration (GO:0072678)2.90680551
88regulation of microtubule-based movement (GO:0060632)2.88923434
89DNA methylation involved in gamete generation (GO:0043046)2.82856181
90regulation of meiosis I (GO:0060631)2.82734028
91regulation of female gonad development (GO:2000194)2.81913684
92G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80835644
93alanine transport (GO:0032328)2.80593763
94ventricular system development (GO:0021591)2.75050714
95regulation of interleukin-13 production (GO:0032656)2.74064325
96cilium assembly (GO:0042384)2.73983516
97pyrimidine dimer repair (GO:0006290)2.72363037
98cilium organization (GO:0044782)2.70717793
99intraciliary transport (GO:0042073)2.69105415
100pattern specification involved in kidney development (GO:0061004)10.2231510

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.79556674
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.62639007
3ZNF274_21170338_ChIP-Seq_K562_Hela3.15132178
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.09756178
5CBP_20019798_ChIP-Seq_JUKART_Human3.07420205
6IRF4_20064451_ChIP-Seq_CD4+T_Mouse3.07420205
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65939614
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.63489433
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24839045
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24183022
11FUS_26573619_Chip-Seq_HEK293_Human2.22407443
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22214937
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.19770072
14WDR5_24793694_ChIP-Seq_LNCAP_Human2.13326627
15ELF1_20517297_ChIP-Seq_JURKAT_Human1.99952189
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.99200868
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95375177
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89377642
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89377642
20ERA_21632823_ChIP-Seq_H3396_Human1.79724316
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77598565
22RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.76540465
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.73930107
24RAC3_21632823_ChIP-Seq_H3396_Human1.69855446
25ER_23166858_ChIP-Seq_MCF-7_Human1.69660403
26BCL6_27268052_Chip-Seq_Bcells_Human1.69180793
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.69129609
28EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.65892475
29NANOG_20526341_ChIP-Seq_ESCs_Human1.62859951
30PHF8_20622854_ChIP-Seq_HELA_Human1.60567566
31TAF2_19829295_ChIP-Seq_ESCs_Human1.55588096
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.54907396
33E2F1_20622854_ChIP-Seq_HELA_Human1.53170254
34ERG_20517297_ChIP-Seq_VCAP_Human1.52885056
35CTCF_20526341_ChIP-Seq_ESCs_Human1.47734804
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.47419175
37AR_21572438_ChIP-Seq_LNCaP_Human1.45257207
38CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43568100
39YY1_22570637_ChIP-Seq_MALME-3M_Human1.43225898
40MYC_19829295_ChIP-Seq_ESCs_Human1.42694979
41HNFA_21074721_ChIP-Seq_CACO-2_Human1.40848447
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40813873
43RBPJ_21746931_ChIP-Seq_IB4_Human1.40082789
44ETV1_20927104_ChIP-Seq_GIST48_Human1.39441656
45EZH2_22144423_ChIP-Seq_EOC_Human1.38812804
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38758639
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36582375
48P300_27268052_Chip-Seq_Bcells_Human1.34367577
49BCOR_27268052_Chip-Seq_Bcells_Human1.33790070
50SMAD4_21741376_ChIP-Seq_EPCs_Human1.33106549
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.32170564
52PHF8_20622853_ChIP-Seq_HELA_Human1.31899825
53GATA1_22025678_ChIP-Seq_K562_Human1.31841254
54P68_20966046_ChIP-Seq_HELA_Human1.30484255
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.29290448
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27357712
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26858334
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26798864
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26627975
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.24792976
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.22936341
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22377535
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.21844168
64OCT4_20526341_ChIP-Seq_ESCs_Human1.19664623
65TAF15_26573619_Chip-Seq_HEK293_Human1.17798190
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16894923
67P300_19829295_ChIP-Seq_ESCs_Human1.16867901
68DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16190461
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15836917
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.15836917
71CIITA_25753668_ChIP-Seq_RAJI_Human1.13957939
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12556241
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11981122
74NFYB_21822215_ChIP-Seq_K562_Human1.11475437
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10936341
76SMC4_20622854_ChIP-Seq_HELA_Human1.10901519
77CEBPB_22108803_ChIP-Seq_LS180_Human1.10247626
78SOX2_22085726_ChIP-Seq_NPCs_Mouse1.10044002
79P53_21459846_ChIP-Seq_SAOS-2_Human1.07815623
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06714121
81IGF1R_20145208_ChIP-Seq_DFB_Human1.05608341
82HOXB7_26014856_ChIP-Seq_BT474_Human1.04889477
83GATA3_26560356_Chip-Seq_TH1_Human1.03464433
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01881965
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01011464
86NCOR_22424771_ChIP-Seq_293T_Human1.00650186
87TP53_18474530_ChIP-ChIP_U2OS_Human0.99702907
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99090527
89VDR_23849224_ChIP-Seq_CD4+_Human0.97951745
90GBX2_23144817_ChIP-Seq_PC3_Human0.96074088
91AR_25329375_ChIP-Seq_VCAP_Human0.95723344
92RUNX2_22187159_ChIP-Seq_PCA_Human0.94906052
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.94666928
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94373888
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.93447347
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.92361876
97NANOG_19829295_ChIP-Seq_ESCs_Human0.91828424
98SOX2_19829295_ChIP-Seq_ESCs_Human0.91828424
99VDR_22108803_ChIP-Seq_LS180_Human0.90740882
100TP63_22573176_ChIP-Seq_HFKS_Human0.90387924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.26637474
2MP0005451_abnormal_body_composition3.78212226
3MP0005670_abnormal_white_adipose3.73206883
4MP0003698_abnormal_male_reproductive3.64813518
5MP0005377_hearing/vestibular/ear_phenot3.47212371
6MP0003878_abnormal_ear_physiology3.47212371
7MP0001929_abnormal_gametogenesis3.36280535
8MP0003011_delayed_dark_adaptation2.61285913
9MP0002822_catalepsy2.41315582
10MP0002161_abnormal_fertility/fecundity2.13122331
11MP0001984_abnormal_olfaction1.99575745
12MP0003718_maternal_effect1.94644433
13MP0010094_abnormal_chromosome_stability1.92168456
14MP0002876_abnormal_thyroid_physiology1.88954886
15MP0001529_abnormal_vocalization1.84560856
16MP0009697_abnormal_copulation1.78215631
17MP0005397_hematopoietic_system_phenotyp1.74229319
18MP0001545_abnormal_hematopoietic_system1.74229319
19MP0005248_abnormal_Harderian_gland1.72887579
20MP0001348_abnormal_lacrimal_gland1.72530655
21MP0003077_abnormal_cell_cycle1.72338376
22MP0002210_abnormal_sex_determination1.62415670
23MP0002138_abnormal_hepatobiliary_system1.62207908
24MP0008877_abnormal_DNA_methylation1.59473469
25MP0005253_abnormal_eye_physiology1.45701116
26MP0006276_abnormal_autonomic_nervous1.39092425
27MP0008007_abnormal_cellular_replicative1.34303280
28MP0009278_abnormal_bone_marrow1.31095606
29MP0003880_abnormal_central_pattern1.30819456
30MP0005551_abnormal_eye_electrophysiolog1.28602554
31MP0003646_muscle_fatigue1.27273657
32MP0001145_abnormal_male_reproductive1.24242527
33MP0005379_endocrine/exocrine_gland_phen1.24240645
34MP0001905_abnormal_dopamine_level1.24026185
35MP0010386_abnormal_urinary_bladder1.23978309
36MP0002653_abnormal_ependyma_morphology1.23800749
37MP0000653_abnormal_sex_gland1.23485130
38MP0003632_abnormal_nervous_system1.23257252
39MP0001764_abnormal_homeostasis1.20896984
40MP0003656_abnormal_erythrocyte_physiolo1.19753399
41MP0003329_amyloid_beta_deposits1.19455060
42MP0000604_amyloidosis1.19087766
43MP0001485_abnormal_pinna_reflex1.17179391
44MP0000678_abnormal_parathyroid_gland1.16282705
45MP0001486_abnormal_startle_reflex1.15713443
46MP0005083_abnormal_biliary_tract1.15454973
47MP0003787_abnormal_imprinting1.12754640
48MP0003121_genomic_imprinting1.12179029
49MP0004957_abnormal_blastocyst_morpholog1.09358457
50MP0010307_abnormal_tumor_latency1.08182701
51MP0000516_abnormal_urinary_system1.07031145
52MP0005367_renal/urinary_system_phenotyp1.07031145
53MP0002127_abnormal_cardiovascular_syste1.06969894
54MP0005394_taste/olfaction_phenotype1.06856837
55MP0005499_abnormal_olfactory_system1.06856837
56MP0002557_abnormal_social/conspecific_i1.06199509
57MP0002229_neurodegeneration1.00894583
58MP0003879_abnormal_hair_cell0.99113301
59MP0008789_abnormal_olfactory_epithelium0.98678800
60MP0001968_abnormal_touch/_nociception0.97411607
61MP0002638_abnormal_pupillary_reflex0.96480094
62MP0008875_abnormal_xenobiotic_pharmacok0.94361347
63MP0003183_abnormal_peptide_metabolism0.92002047
64MP0005671_abnormal_response_to0.86631826
65MP0003693_abnormal_embryo_hatching0.84303655
66MP0005395_other_phenotype0.83997936
67MP0002067_abnormal_sensory_capabilities0.83891194
68MP0000534_abnormal_ureter_morphology0.83593408
69MP0000681_abnormal_thyroid_gland0.82939468
70MP0000778_abnormal_nervous_system0.82149367
71MP0008058_abnormal_DNA_repair0.79304178
72MP0003959_abnormal_lean_body0.77803993
73MP0003631_nervous_system_phenotype0.76646928
74MP0008932_abnormal_embryonic_tissue0.74012305
75MP0004742_abnormal_vestibular_system0.73979816
76MP0002572_abnormal_emotion/affect_behav0.70622628
77MP0009745_abnormal_behavioral_response0.69191933
78MP0000955_abnormal_spinal_cord0.68527276
79MP0009046_muscle_twitch0.67696824
80MP0003137_abnormal_impulse_conducting0.67582673
81MP0004859_abnormal_synaptic_plasticity0.67516997
82MP0002009_preneoplasia0.65214210
83MP0000026_abnormal_inner_ear0.64868432
84MP0009764_decreased_sensitivity_to0.63818316
85MP0009785_altered_susceptibility_to0.62631494
86MP0001727_abnormal_embryo_implantation0.62336058
87MP0002282_abnormal_trachea_morphology0.61241546
88MP0001963_abnormal_hearing_physiology0.61063577
89MP0002735_abnormal_chemical_nociception0.60512401
90MP0003136_yellow_coat_color0.60190123
91MP0005075_abnormal_melanosome_morpholog0.59572916
92MP0005391_vision/eye_phenotype0.58793807
93MP0005310_abnormal_salivary_gland0.58141268
94MP0003385_abnormal_body_wall0.57743879
95MP0002269_muscular_atrophy0.56315887
96MP0002234_abnormal_pharynx_morphology0.55521151
97MP0009765_abnormal_xenobiotic_induced0.53981837
98MP0002132_abnormal_respiratory_system0.53030001
99MP0002006_tumorigenesis0.52880939
100MP0000358_abnormal_cell_content/0.52800660

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.37323185
2Hypoplasia of the thymus (HP:0000778)5.88634979
3Resting tremor (HP:0002322)4.65338002
4Tubulointerstitial nephritis (HP:0001970)4.56967321
5Severe visual impairment (HP:0001141)3.97891738
6Asymmetric septal hypertrophy (HP:0001670)3.97328855
7Attenuation of retinal blood vessels (HP:0007843)3.75897960
8Absent/shortened dynein arms (HP:0200106)3.57523285
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.57523285
10Postural instability (HP:0002172)3.51351174
11Bony spicule pigmentary retinopathy (HP:0007737)3.31737695
12Volvulus (HP:0002580)3.27913894
13Aplasia/Hypoplasia of the earlobes (HP:0009906)3.23770271
14Abnormal respiratory motile cilium morphology (HP:0005938)3.17785670
15Abnormal respiratory epithelium morphology (HP:0012253)3.17785670
16Abnormal respiratory motile cilium physiology (HP:0012261)3.14258578
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11481900
18Nephronophthisis (HP:0000090)3.09253727
19Cerebellar dysplasia (HP:0007033)3.08197031
20Impulsivity (HP:0100710)3.02892739
21Abnormality of dental color (HP:0011073)3.01495468
22Infertility (HP:0000789)2.98047624
23Brushfield spots (HP:0001088)2.89164998
24Abnormal ciliary motility (HP:0012262)2.88922719
25Abnormal rod and cone electroretinograms (HP:0008323)2.86195364
26Chronic hepatic failure (HP:0100626)2.85756205
27Enlarged epiphyses (HP:0010580)2.83449908
28B lymphocytopenia (HP:0010976)2.81961122
29Type II lissencephaly (HP:0007260)2.72116853
30Abnormality of the renal medulla (HP:0100957)2.68304746
31Nasal polyposis (HP:0100582)2.67501888
32Severe combined immunodeficiency (HP:0004430)2.67344915
33Hypochromic microcytic anemia (HP:0004840)2.63370855
34Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.62953670
35Hypoproteinemia (HP:0003075)2.57261187
36Aplasia/Hypoplasia of the thymus (HP:0010515)2.53755527
37Male infertility (HP:0003251)2.50631759
38Tubulointerstitial abnormality (HP:0001969)2.50343601
39Abnormality of the parathyroid morphology (HP:0011766)2.49087994
40Generalized aminoaciduria (HP:0002909)2.48392477
41Median cleft lip (HP:0000161)2.48107645
42Thyroiditis (HP:0100646)2.47818459
43Split foot (HP:0001839)2.40855496
44Abnormality of lateral ventricle (HP:0030047)2.40350772
45Abnormal urine output (HP:0012590)2.38215562
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36820610
47Abnormality of B cell number (HP:0010975)2.34404156
48Double outlet right ventricle (HP:0001719)2.30346534
49Congenital malformation of the right heart (HP:0011723)2.30346534
50Duodenal stenosis (HP:0100867)2.29792617
51Small intestinal stenosis (HP:0012848)2.29792617
52Amelogenesis imperfecta (HP:0000705)2.29327695
53Hypoplastic ischia (HP:0003175)2.28036815
54Hyperkalemia (HP:0002153)2.27881009
55Renovascular hypertension (HP:0100817)2.27759803
56Abnormality of macular pigmentation (HP:0008002)2.27745922
57Medial flaring of the eyebrow (HP:0010747)2.25394543
58Bell-shaped thorax (HP:0001591)2.24724106
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.20891668
60Renal salt wasting (HP:0000127)2.19910135
61Molar tooth sign on MRI (HP:0002419)2.19739279
62Abnormality of midbrain morphology (HP:0002418)2.19739279
63Failure to thrive in infancy (HP:0001531)2.19016867
64Polyuria (HP:0000103)2.15513377
65Medulloblastoma (HP:0002885)2.15200957
66Abnormality of the costochondral junction (HP:0000919)2.14507441
67Combined immunodeficiency (HP:0005387)2.14347707
68Abnormality of fatty-acid metabolism (HP:0004359)2.10968346
69Decreased central vision (HP:0007663)2.06040263
70Widely patent fontanelles and sutures (HP:0004492)2.05959622
71Abnormal spermatogenesis (HP:0008669)2.05681915
72Polydipsia (HP:0001959)2.03738866
73Abnormal drinking behavior (HP:0030082)2.03738866
74Myoglobinuria (HP:0002913)2.01194839
75Abnormality of the duodenum (HP:0002246)1.99150156
76Retinal dysplasia (HP:0007973)1.98335310
77Hyponatremia (HP:0002902)1.98107004
78Panhypogammaglobulinemia (HP:0003139)1.95904748
79Abnormality of the aortic arch (HP:0012303)1.95373352
80Facial shape deformation (HP:0011334)1.94292922
81Potter facies (HP:0002009)1.94292922
82Abnormality of the nasal mucosa (HP:0000433)1.91125124
83Hypoparathyroidism (HP:0000829)1.90934045
84Abnormality of renal excretion (HP:0011036)1.88871543
85Abnormality of the frontal sinuses (HP:0002687)1.88851730
86Abnormality of the ischium (HP:0003174)1.88662093
87Stage 5 chronic kidney disease (HP:0003774)1.87784960
88Epiphyseal stippling (HP:0010655)1.87115562
89Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84701479
90Rhabdomyolysis (HP:0003201)1.83538375
91Renal dysplasia (HP:0000110)1.83170918
92Peripheral hypomyelination (HP:0007182)1.81572729
93Progressive cerebellar ataxia (HP:0002073)1.81502103
94Abnormality of the renal cortex (HP:0011035)1.80681780
95Congenital stationary night blindness (HP:0007642)1.80030707
96Neurodegeneration (HP:0002180)1.78776223
97Aplastic anemia (HP:0001915)1.78597855
98Multicystic kidney dysplasia (HP:0000003)1.75785104
99Pancreatic cysts (HP:0001737)1.74532626
100Posterior embryotoxon (HP:0000627)1.74483651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.03298879
2PIM25.05526232
3TESK14.09360746
4EIF2AK33.91409781
5BMPR1B2.96478489
6PLK22.95628564
7DYRK1B2.58407553
8PRKD32.33703668
9MAP4K22.09564749
10PBK2.00031692
11DDR21.96648513
12TESK21.85940478
13INSRR1.80844170
14EIF2AK11.75856321
15TAOK31.73864853
16BRD41.63233258
17BCKDK1.57737655
18CDK81.55371342
19STK381.52504172
20MAP3K41.46897310
21MAP3K51.44914301
22TRIM281.44158597
23PDK21.42933775
24PNCK1.31626163
25PINK11.30658299
26SCYL21.14405084
27NEK61.13566538
28MAPK151.13196001
29MAP2K71.13101054
30TGFBR11.10725140
31FLT31.10280142
32MAPK131.09147860
33CDK71.08293621
34TAF11.04021871
35SRPK11.01170125
36PDPK10.96571798
37CSNK1G30.96531732
38PDK10.96490295
39NUAK10.96413402
40BCR0.94572972
41PIK3CG0.92094565
42MST1R0.91451048
43KIT0.90350051
44CAMK1G0.89009290
45AKT30.88799809
46MAPKAPK30.88413068
47WNK40.86824553
48PTK2B0.85082998
49ZAK0.84569776
50PIM10.81142866
51CSNK1A1L0.80995202
52EEF2K0.75655808
53CSNK1G20.74504213
54UHMK10.73372142
55STK390.72980702
56CCNB10.68677809
57CSNK1G10.68137337
58STK38L0.67427841
59ABL20.65394067
60CDK90.62821658
61NEK20.62581427
62ATR0.59307421
63ADRBK20.57633386
64BRAF0.56764781
65MUSK0.54503999
66CDK140.50890516
67MAP3K20.50173557
68CDK20.48564330
69RPS6KA40.48300438
70WNK10.46156229
71JAK20.43876320
72ATM0.43673666
73PLK10.43582332
74CDK60.42457669
75CDK190.42219281
76NEK10.41814379
77CHEK10.41661868
78CDK10.41607503
79DYRK30.39930319
80GRK10.39235341
81TTK0.39023075
82RPS6KL10.38779683
83RPS6KC10.38779683
84RPS6KA60.37712282
85SYK0.37650519
86RPS6KA10.36198706
87MAPK10.36071623
88PKN10.35263311
89GSK3B0.32907683
90MAPK140.30903815
91VRK10.30399062
92MAPK110.29905636
93SIK20.29652948
94RPS6KA20.28022966
95LATS10.28019916
96MAP3K110.25812503
97WNK30.25738162
98JAK30.25643835
99PRKCQ0.24865592
100BUB10.23069446

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.22988079
2Fatty acid biosynthesis_Homo sapiens_hsa000613.77724843
3Caffeine metabolism_Homo sapiens_hsa002323.63487393
4Steroid biosynthesis_Homo sapiens_hsa001003.06042281
5Proteasome_Homo sapiens_hsa030502.74013839
6Olfactory transduction_Homo sapiens_hsa047402.47128461
7Basal transcription factors_Homo sapiens_hsa030222.38654805
8Fanconi anemia pathway_Homo sapiens_hsa034602.16604833
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07915291
10Butanoate metabolism_Homo sapiens_hsa006502.05764250
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.90012544
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79273679
13RNA transport_Homo sapiens_hsa030131.76521491
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69122645
15Primary immunodeficiency_Homo sapiens_hsa053401.69018135
16Fatty acid metabolism_Homo sapiens_hsa012121.66550694
17Propanoate metabolism_Homo sapiens_hsa006401.64722202
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58684663
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58133299
20Peroxisome_Homo sapiens_hsa041461.57532468
21Phototransduction_Homo sapiens_hsa047441.56150177
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54218026
23Homologous recombination_Homo sapiens_hsa034401.45582848
24Oocyte meiosis_Homo sapiens_hsa041141.35699986
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35270550
26Selenocompound metabolism_Homo sapiens_hsa004501.34169687
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33979146
28Fatty acid degradation_Homo sapiens_hsa000711.32596764
29Non-homologous end-joining_Homo sapiens_hsa034501.30426899
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26937619
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22251442
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19142800
33Taste transduction_Homo sapiens_hsa047421.18696182
34Arginine and proline metabolism_Homo sapiens_hsa003301.17960125
35Purine metabolism_Homo sapiens_hsa002301.15257347
36Cell cycle_Homo sapiens_hsa041101.14614650
37Base excision repair_Homo sapiens_hsa034101.13169111
38Synaptic vesicle cycle_Homo sapiens_hsa047211.12589931
39mRNA surveillance pathway_Homo sapiens_hsa030151.11491596
40Nicotine addiction_Homo sapiens_hsa050331.11104477
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08657484
42RNA degradation_Homo sapiens_hsa030181.05012332
43Phenylalanine metabolism_Homo sapiens_hsa003601.04958037
44Carbon metabolism_Homo sapiens_hsa012001.04473703
45Biosynthesis of amino acids_Homo sapiens_hsa012301.03868713
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.01520672
47Mismatch repair_Homo sapiens_hsa034300.94549324
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.91427069
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91245297
50Regulation of autophagy_Homo sapiens_hsa041400.90039194
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89022433
52RNA polymerase_Homo sapiens_hsa030200.85490226
53Sulfur relay system_Homo sapiens_hsa041220.84321815
54Lysine degradation_Homo sapiens_hsa003100.81808356
55Huntingtons disease_Homo sapiens_hsa050160.78413196
56Fatty acid elongation_Homo sapiens_hsa000620.76984975
57PPAR signaling pathway_Homo sapiens_hsa033200.76035167
58Spliceosome_Homo sapiens_hsa030400.69913922
59Circadian rhythm_Homo sapiens_hsa047100.69447230
60Pyrimidine metabolism_Homo sapiens_hsa002400.68478482
61Metabolic pathways_Homo sapiens_hsa011000.66784494
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66100035
63Retinol metabolism_Homo sapiens_hsa008300.64458873
64Endocytosis_Homo sapiens_hsa041440.63078273
65Epstein-Barr virus infection_Homo sapiens_hsa051690.61305609
66Renin-angiotensin system_Homo sapiens_hsa046140.60884454
67beta-Alanine metabolism_Homo sapiens_hsa004100.60633296
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.59918936
69Nucleotide excision repair_Homo sapiens_hsa034200.58146043
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.57980738
71Antigen processing and presentation_Homo sapiens_hsa046120.57542647
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56674236
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.55872780
74Tyrosine metabolism_Homo sapiens_hsa003500.55144236
75Cardiac muscle contraction_Homo sapiens_hsa042600.54430009
76Herpes simplex infection_Homo sapiens_hsa051680.53960621
77Arginine biosynthesis_Homo sapiens_hsa002200.53946685
78ABC transporters_Homo sapiens_hsa020100.52499966
79Viral carcinogenesis_Homo sapiens_hsa052030.52261311
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.50490031
81p53 signaling pathway_Homo sapiens_hsa041150.48223071
82Dorso-ventral axis formation_Homo sapiens_hsa043200.47611844
83Fat digestion and absorption_Homo sapiens_hsa049750.46980009
84Chemical carcinogenesis_Homo sapiens_hsa052040.46492142
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43744336
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.41033596
87Nitrogen metabolism_Homo sapiens_hsa009100.37856245
88Autoimmune thyroid disease_Homo sapiens_hsa053200.37521166
89Pyruvate metabolism_Homo sapiens_hsa006200.36629469
90AMPK signaling pathway_Homo sapiens_hsa041520.35529875
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34652368
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33267193
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.32666861
94Viral myocarditis_Homo sapiens_hsa054160.28518313
95Type I diabetes mellitus_Homo sapiens_hsa049400.28347207
96Allograft rejection_Homo sapiens_hsa053300.28030704
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23639941
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23408515
99Type II diabetes mellitus_Homo sapiens_hsa049300.23196169
100Graft-versus-host disease_Homo sapiens_hsa053320.22400344

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