ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	9.79647908
2	sperm motility (GO:0030317)	9.69777000
3	protein targeting to Golgi (GO:0000042)	8.14163834
4	establishment of protein localization to Golgi (GO:0072600)	7.81531008
5	fusion of sperm to egg plasma membrane (GO:0007342)	7.63301485
6	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.62400843
7	acrosome reaction (GO:0007340)	7.20530184
8	single strand break repair (GO:0000012)	6.96736006
9	response to pheromone (GO:0019236)	6.95759754
10	rRNA methylation (GO:0031167)	6.79072147
11	microtubule depolymerization (GO:0007019)	6.71662881
12	centriole replication (GO:0007099)	6.49009306
13	chromosome condensation (GO:0030261)	6.42343519
14	DNA packaging (GO:0006323)	6.21868620
15	microtubule polymerization or depolymerization (GO:0031109)	6.13459589
16	protein localization to Golgi apparatus (GO:0034067)	6.07976725
17	regulation of centriole replication (GO:0046599)	5.95719938
18	epithelial cilium movement (GO:0003351)	5.82674723
19	microtubule nucleation (GO:0007020)	5.78111021
20	plasma membrane fusion (GO:0045026)	5.68384930
21	sperm capacitation (GO:0048240)	5.61166370
22	spermatid nucleus differentiation (GO:0007289)	5.59647849
23	seminiferous tubule development (GO:0072520)	5.56076626
24	centriole assembly (GO:0098534)	5.44823477
25	regulation of cilium movement (GO:0003352)	5.43971256
26	axonemal dynein complex assembly (GO:0070286)	5.34813143
27	rRNA modification (GO:0000154)	5.32678802
28	spermatid development (GO:0007286)	5.28129947
29	spermatogenesis (GO:0007283)	5.12697187
30	male gamete generation (GO:0048232)	5.11010663
31	motile cilium assembly (GO:0044458)	5.06260283
32	sperm-egg recognition (GO:0035036)	5.04321408
33	glomerular visceral epithelial cell development (GO:0072015)	4.98129383
34	nuclear pore complex assembly (GO:0051292)	4.92624546
35	cilium or flagellum-dependent cell motility (GO:0001539)	4.80057493
36	gamete generation (GO:0007276)	4.76497272
37	cilium movement (GO:0003341)	4.75437482
38	multicellular organism reproduction (GO:0032504)	4.63964975
39	RNA destabilization (GO:0050779)	4.60698760
40	glomerular epithelial cell development (GO:0072310)	4.58358369
41	binding of sperm to zona pellucida (GO:0007339)	4.52967748
42	single fertilization (GO:0007338)	4.40203215
43	reproduction (GO:0000003)	4.27931793
44	fertilization (GO:0009566)	4.25148627
45	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.24916943
46	axoneme assembly (GO:0035082)	4.24471337
47	cell wall macromolecule catabolic process (GO:0016998)	4.14136091
48	cell-cell recognition (GO:0009988)	4.09271774
49	nuclear pore organization (GO:0006999)	4.08937964
50	phosphatidylethanolamine metabolic process (GO:0046337)	4.02395023
51	sexual reproduction (GO:0019953)	3.97196448
52	calcium ion-dependent exocytosis (GO:0017156)	3.88475307
53	microtubule severing (GO:0051013)	3.87374574
54	intra-Golgi vesicle-mediated transport (GO:0006891)	3.86168828
55	pore complex assembly (GO:0046931)	3.78915478
56	glycerol ether metabolic process (GO:0006662)	3.78291175
57	cell wall macromolecule metabolic process (GO:0044036)	3.77804173
58	RNA localization (GO:0006403)	3.71162605
59	negative regulation of axon guidance (GO:1902668)	3.69680596
60	C4-dicarboxylate transport (GO:0015740)	3.69678436
61	multicellular organismal reproductive process (GO:0048609)	3.68287089
62	pyrimidine dimer repair (GO:0006290)	3.65795877
63	ventricular system development (GO:0021591)	3.65541533
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.60142594
65	ether metabolic process (GO:0018904)	3.52458816
66	histone mRNA catabolic process (GO:0071044)	3.45693205
67	multicellular organismal movement (GO:0050879)	3.39920176
68	musculoskeletal movement (GO:0050881)	3.39920176
69	nucleus organization (GO:0006997)	3.30077894
70	cilium organization (GO:0044782)	3.26069115
71	cilium assembly (GO:0042384)	3.24552782
72	regulation of microtubule-based movement (GO:0060632)	3.24003533
73	regulation of Rab GTPase activity (GO:0032313)	3.22588200
74	positive regulation of Rab GTPase activity (GO:0032851)	3.22588200
75	piRNA metabolic process (GO:0034587)	3.22319535
76	chromatin silencing (GO:0006342)	3.03592421
77	DNA methylation involved in gamete generation (GO:0043046)	3.02802484
78	protein K48-linked deubiquitination (GO:0071108)	3.01609945
79	germ cell development (GO:0007281)	2.99095531
80	histone H3-K9 demethylation (GO:0033169)	2.98582321
81	tRNA methylation (GO:0030488)	2.97663866
82	cerebral cortex neuron differentiation (GO:0021895)	2.96139733
83	glycolytic process (GO:0006096)	2.95199629
84	positive regulation of mitochondrial fission (GO:0090141)	2.91384255
85	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.88473089
86	RNA methylation (GO:0001510)	2.86703609
87	regulation of centrosome duplication (GO:0010824)	2.84689387
88	peptidyl-glutamic acid modification (GO:0018200)	2.81015809
89	regulation of DNA endoreduplication (GO:0032875)	2.73036458
90	cellular ketone body metabolic process (GO:0046950)	2.72298550
91	response to misfolded protein (GO:0051788)	2.68424765
92	synapsis (GO:0007129)	2.68015126
93	coenzyme catabolic process (GO:0009109)	2.64565750
94	microtubule bundle formation (GO:0001578)	2.58969509
95	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.57875782
96	cellular response to exogenous dsRNA (GO:0071360)	2.54831301
97	male meiosis (GO:0007140)	2.50468671
98	resolution of meiotic recombination intermediates (GO:0000712)	2.49861327
99	nucleosome disassembly (GO:0006337)	2.48523421
100	protein-DNA complex disassembly (GO:0032986)	2.48523421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.74342600
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.26659776
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.25960946
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.03772954
5	FUS_26573619_Chip-Seq_HEK293_Human	2.78015988
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.63682886
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.59643026
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44447479
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.43452003
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.36232436
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.36232436
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.29589205
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27990708
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.23369942
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.86268389
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85654199
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.78985408
18	P300_19829295_ChIP-Seq_ESCs_Human	1.78146403
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78056329
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.76872901
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.74820091
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73482810
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.73482810
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71343848
25	STAT3_23295773_ChIP-Seq_U87_Human	1.70740849
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69682160
27	RAC3_21632823_ChIP-Seq_H3396_Human	1.69219837
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.61958464
29	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.57147080
30	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.54768184
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48106219
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.46885398
33	AR_25329375_ChIP-Seq_VCAP_Human	1.43715552
34	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.43466949
35	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.43090663
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.42022452
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.41737664
38	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.40929002
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40645614
40	NFYB_21822215_ChIP-Seq_K562_Human	1.39862843
41	TP53_18474530_ChIP-ChIP_U2OS_Human	1.39399980
42	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.39329630
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38573265
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36907865
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35975511
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.35247254
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.33764022
48	ERA_21632823_ChIP-Seq_H3396_Human	1.33705111
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.33514422
50	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33308228
51	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.32241659
52	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.32032124
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30562315
54	TBL1_22424771_ChIP-Seq_293T_Human	1.30204270
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29567779
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28515530
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28120791
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27314745
59	PHF8_20622853_ChIP-Seq_HELA_Human	1.26864112
60	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26563488
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25567607
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25408586
63	TCF4_23295773_ChIP-Seq_U87_Human	1.25084029
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24875888
65	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.24378068
66	RBPJ_21746931_ChIP-Seq_IB4_Human	1.23565967
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.23560624
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20563764
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19354077
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.19156902
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.18943085
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.17989934
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16808687
74	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.14166392
75	DROSHA_22980978_ChIP-Seq_HELA_Human	1.12685993
76	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.11935028
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08376048
78	NFYA_21822215_ChIP-Seq_K562_Human	1.07852945
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07188611
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07188611
81	NCOR_22424771_ChIP-Seq_293T_Human	1.07035467
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06729572
83	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.05850803
84	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03829151
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03793867
86	SOX9_26525672_Chip-Seq_HEART_Mouse	1.02481628
87	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.02312786
88	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02164373
89	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.02150010
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00861863
91	JUN_21703547_ChIP-Seq_K562_Human	0.98573274
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97840386
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97814419
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96030606
95	AHR_22903824_ChIP-Seq_MCF-7_Human	0.95091128
96	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95070100
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94891264
98	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.94284046
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.94204141
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94192587

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.29008206
2	MP0003878_abnormal_ear_physiology	3.96999755
3	MP0005377_hearing/vestibular/ear_phenot	3.96999755
4	MP0003698_abnormal_male_reproductive	3.09319821
5	MP0005379_endocrine/exocrine_gland_phen	2.94833172
6	MP0001929_abnormal_gametogenesis	2.73981328
7	MP0001348_abnormal_lacrimal_gland	2.72699196
8	MP0005253_abnormal_eye_physiology	2.40789115
9	MP0001529_abnormal_vocalization	2.29002140
10	MP0001984_abnormal_olfaction	2.26172046
11	MP0005451_abnormal_body_composition	2.25971761
12	MP0001485_abnormal_pinna_reflex	2.16705240
13	MP0002282_abnormal_trachea_morphology	2.13206592
14	MP0003718_maternal_effect	1.95226685
15	MP0003880_abnormal_central_pattern	1.94487234
16	MP0005551_abnormal_eye_electrophysiolog	1.87962157
17	MP0001486_abnormal_startle_reflex	1.82190343
18	MP0008789_abnormal_olfactory_epithelium	1.81319706
19	MP0008872_abnormal_physiological_respon	1.77647148
20	MP0002161_abnormal_fertility/fecundity	1.71516906
21	MP0002102_abnormal_ear_morphology	1.67038380
22	MP0002163_abnormal_gland_morphology	1.59386777
23	MP0005670_abnormal_white_adipose	1.56108133
24	MP0003011_delayed_dark_adaptation	1.53950337
25	MP0005394_taste/olfaction_phenotype	1.52377708
26	MP0005499_abnormal_olfactory_system	1.52377708
27	MP0003646_muscle_fatigue	1.51237100
28	MP0005248_abnormal_Harderian_gland	1.46705665
29	MP0005083_abnormal_biliary_tract	1.44279062
30	MP0004742_abnormal_vestibular_system	1.43331297
31	MP0006276_abnormal_autonomic_nervous	1.41852803
32	MP0002210_abnormal_sex_determination	1.41116755
33	MP0008058_abnormal_DNA_repair	1.35938024
34	MP0002090_abnormal_vision	1.31449829
35	MP0002928_abnormal_bile_duct	1.28720260
36	MP0003879_abnormal_hair_cell	1.26045912
37	MP0000569_abnormal_digit_pigmentation	1.24693484
38	MP0001145_abnormal_male_reproductive	1.24122363
39	MP0002160_abnormal_reproductive_system	1.24002996
40	MP0001963_abnormal_hearing_physiology	1.22080466
41	MP0005423_abnormal_somatic_nervous	1.21864174
42	MP0002132_abnormal_respiratory_system	1.19961367
43	MP0008877_abnormal_DNA_methylation	1.18809166
44	MP0000613_abnormal_salivary_gland	1.16262210
45	MP0000653_abnormal_sex_gland	1.13580762
46	MP0005391_vision/eye_phenotype	1.12592781
47	MP0003137_abnormal_impulse_conducting	1.10035048
48	MP0002229_neurodegeneration	1.09496079
49	MP0000678_abnormal_parathyroid_gland	1.08304732
50	MP0004043_abnormal_pH_regulation	1.08196297
51	MP0006072_abnormal_retinal_apoptosis	1.06830735
52	MP0003656_abnormal_erythrocyte_physiolo	1.04113794
53	MP0001764_abnormal_homeostasis	1.01370250
54	MP0002557_abnormal_social/conspecific_i	0.98795977
55	MP0001905_abnormal_dopamine_level	0.98732758
56	MP0002638_abnormal_pupillary_reflex	0.98485734
57	MP0000372_irregular_coat_pigmentation	0.95830311
58	MP0005332_abnormal_amino_acid	0.95226353
59	MP0005084_abnormal_gallbladder_morpholo	0.95133240
60	MP0002653_abnormal_ependyma_morphology	0.94834847
61	MP0009053_abnormal_anal_canal	0.92917685
62	MP0010094_abnormal_chromosome_stability	0.92277987
63	MP0005395_other_phenotype	0.91785439
64	MP0008007_abnormal_cellular_replicative	0.90469402
65	MP0004859_abnormal_synaptic_plasticity	0.87647382
66	MP0005310_abnormal_salivary_gland	0.84243193
67	MP0004924_abnormal_behavior	0.82462094
68	MP0005386_behavior/neurological_phenoty	0.82462094
69	MP0002234_abnormal_pharynx_morphology	0.79651948
70	MP0001765_abnormal_ion_homeostasis	0.79511474
71	MP0000955_abnormal_spinal_cord	0.78055793
72	MP0009780_abnormal_chondrocyte_physiolo	0.77973880
73	MP0005367_renal/urinary_system_phenotyp	0.77677294
74	MP0000516_abnormal_urinary_system	0.77677294
75	MP0009697_abnormal_copulation	0.75446033
76	MP0003077_abnormal_cell_cycle	0.75170202
77	MP0000778_abnormal_nervous_system	0.74671558
78	MP0000427_abnormal_hair_cycle	0.72648985
79	MP0002295_abnormal_pulmonary_circulatio	0.71946926
80	MP0002067_abnormal_sensory_capabilities	0.71467778
81	MP0000026_abnormal_inner_ear	0.71329455
82	MP0003329_amyloid_beta_deposits	0.71107172
83	MP0004233_abnormal_muscle_weight	0.70218712
84	MP0009745_abnormal_behavioral_response	0.69856969
85	MP0002736_abnormal_nociception_after	0.68109432
86	MP0009115_abnormal_fat_cell	0.67333297
87	MP0000538_abnormal_urinary_bladder	0.67316713
88	MP0008569_lethality_at_weaning	0.67233967
89	MP0004085_abnormal_heartbeat	0.66498795
90	MP0002572_abnormal_emotion/affect_behav	0.65875435
91	MP0002127_abnormal_cardiovascular_syste	0.65038703
92	MP0008775_abnormal_heart_ventricle	0.64649513
93	MP0006054_spinal_hemorrhage	0.63272753
94	MP0004145_abnormal_muscle_electrophysio	0.60375521
95	MP0001270_distended_abdomen	0.60345149
96	MP0005389_reproductive_system_phenotype	0.59060732
97	MP0003786_premature_aging	0.57740048
98	MP0003633_abnormal_nervous_system	0.57265516
99	MP0005636_abnormal_mineral_homeostasis	0.56167437
100	MP0002822_catalepsy	0.56014436

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	6.24345977
2	Chronic hepatic failure (HP:0100626)	5.80109344
3	Hypoplasia of the thymus (HP:0000778)	5.12835949
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.04161997
5	Absent/shortened dynein arms (HP:0200106)	5.04161997
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.73644899
7	Male infertility (HP:0003251)	4.40318631
8	Abnormal gallbladder physiology (HP:0012438)	4.15802471
9	Cholecystitis (HP:0001082)	4.15802471
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.96580574
11	Pancreatic cysts (HP:0001737)	3.96317068
12	Pancreatic fibrosis (HP:0100732)	3.83078962
13	Abnormal ciliary motility (HP:0012262)	3.82024080
14	True hermaphroditism (HP:0010459)	3.75624537
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.66995233
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.66995233
17	Menstrual irregularities (HP:0000858)	3.46833920
18	Nephronophthisis (HP:0000090)	3.37405421
19	Severe visual impairment (HP:0001141)	3.36076387
20	Tubulointerstitial abnormality (HP:0001969)	3.35208773
21	Cone-rod dystrophy (HP:0000548)	3.33987306
22	Hypoalphalipoproteinemia (HP:0003233)	3.28258523
23	Progressive cerebellar ataxia (HP:0002073)	3.15556385
24	Nasal polyposis (HP:0100582)	3.15466831
25	Bony spicule pigmentary retinopathy (HP:0007737)	3.09832287
26	Hypoplastic pelvis (HP:0008839)	3.07521778
27	Attenuation of retinal blood vessels (HP:0007843)	3.07199670
28	Asymmetric septal hypertrophy (HP:0001670)	3.02710987
29	Hypoalbuminemia (HP:0003073)	3.00514267
30	Abnormal albumin level (HP:0012116)	3.00514267
31	Hypophosphatemic rickets (HP:0004912)	2.91487688
32	Abnormality of dental color (HP:0011073)	2.90499369
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.81060561
34	Rhinitis (HP:0012384)	2.78657343
35	Abnormality of the renal medulla (HP:0100957)	2.72436707
36	Amelogenesis imperfecta (HP:0000705)	2.72246039
37	Hyperkalemia (HP:0002153)	2.70990164
38	Cystic liver disease (HP:0006706)	2.68224226
39	Stage 5 chronic kidney disease (HP:0003774)	2.67912663
40	Severe combined immunodeficiency (HP:0004430)	2.64027591
41	Portal hypertension (HP:0001409)	2.61038639
42	Infertility (HP:0000789)	2.58508502
43	Abnormality of macular pigmentation (HP:0008002)	2.57362231
44	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.55003358
45	Abnormality of the renal cortex (HP:0011035)	2.38936366
46	Abnormality of the hepatic vasculature (HP:0006707)	2.33541637
47	Cholelithiasis (HP:0001081)	2.32877272
48	Occipital encephalocele (HP:0002085)	2.31017922
49	Impulsivity (HP:0100710)	2.28617066
50	Pendular nystagmus (HP:0012043)	2.23673756
51	Abnormality of the nasal mucosa (HP:0000433)	2.22941709
52	Renovascular hypertension (HP:0100817)	2.21573236
53	Truncal obesity (HP:0001956)	2.19173215
54	Thyroiditis (HP:0100646)	2.16803501
55	Congenital hepatic fibrosis (HP:0002612)	2.16369473
56	Renal cortical cysts (HP:0000803)	2.15400165
57	Abnormal spermatogenesis (HP:0008669)	2.12683336
58	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.11225875
59	Anencephaly (HP:0002323)	2.08467847
60	Combined immunodeficiency (HP:0005387)	2.06752833
61	Abnormal gallbladder morphology (HP:0012437)	2.05197262
62	Tubular atrophy (HP:0000092)	2.04131871
63	Bronchiectasis (HP:0002110)	2.03342149
64	Postural instability (HP:0002172)	2.02492059
65	Resting tremor (HP:0002322)	2.01218170
66	Reticulocytosis (HP:0001923)	2.00949082
67	Fibular aplasia (HP:0002990)	2.00079514
68	Postaxial foot polydactyly (HP:0001830)	1.98877943
69	Mesomelia (HP:0003027)	1.97175681
70	Horizontal nystagmus (HP:0000666)	1.95515052
71	Myoglobinuria (HP:0002913)	1.91669628
72	Hypoproteinemia (HP:0003075)	1.89457859
73	Insulin-resistant diabetes mellitus (HP:0000831)	1.88820004
74	Intellectual disability, moderate (HP:0002342)	1.88502039
75	Progressive sensorineural hearing impairment (HP:0000408)	1.87827869
76	Brittle hair (HP:0002299)	1.87725912
77	Hyperglycinemia (HP:0002154)	1.85998961
78	Nephrogenic diabetes insipidus (HP:0009806)	1.83813349
79	Polydipsia (HP:0001959)	1.83485758
80	Abnormal drinking behavior (HP:0030082)	1.83485758
81	Hemiparesis (HP:0001269)	1.80501338
82	Hypoplastic ischia (HP:0003175)	1.78665419
83	Subcapsular cataract (HP:0000523)	1.78256377
84	Focal segmental glomerulosclerosis (HP:0000097)	1.77826853
85	Enlarged kidneys (HP:0000105)	1.76035653
86	Focal motor seizures (HP:0011153)	1.75265306
87	Sandal gap (HP:0001852)	1.74945978
88	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.72447499
89	Chronic bronchitis (HP:0004469)	1.70731158
90	Hyperuricemia (HP:0002149)	1.69103569
91	Increased purine levels (HP:0004368)	1.69103569
92	Abnormality of DNA repair (HP:0003254)	1.68772254
93	Glomerulosclerosis (HP:0000096)	1.68368195
94	Multicystic kidney dysplasia (HP:0000003)	1.68180669
95	Oligohydramnios (HP:0001562)	1.67406966
96	Sloping forehead (HP:0000340)	1.66765156
97	Hemiplegia (HP:0002301)	1.66481302
98	Abnormality of the ischium (HP:0003174)	1.66170416
99	Abnormality of lateral ventricle (HP:0030047)	1.65405569
100	Photophobia (HP:0000613)	1.65003487

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.16686419
2	BRD4	5.25925751
3	MAP4K2	4.11805975
4	INSRR	3.89744118
5	PLK2	3.74066143
6	PNCK	2.45442466
7	PIK3CG	2.44660301
8	CASK	2.00912217
9	TAF1	1.96467867
10	NEK6	1.92821389
11	CAMK1G	1.90685286
12	NUAK1	1.86443109
13	BCKDK	1.82447311
14	TYRO3	1.65034527
15	MARK1	1.64976284
16	TESK1	1.61391643
17	MKNK2	1.60594080
18	MUSK	1.43599892
19	TNIK	1.38951871
20	PRKD3	1.30357396
21	BRSK2	1.28293476
22	SIK2	1.21075314
23	CDK12	1.18440279
24	BRSK1	1.18036071
25	TAOK3	1.17834709
26	FRK	1.15883151
27	PTK2B	1.15235970
28	DYRK3	1.10551579
29	TRIM28	1.01252638
30	SRPK1	0.99179194
31	CSNK1A1L	0.91475914
32	NTRK3	0.90830026
33	DYRK1A	0.90631837
34	LATS1	0.88370311
35	VRK2	0.87359926
36	STK38	0.83274900
37	PIM2	0.81756573
38	MAPK13	0.81593491
39	PDK2	0.81512952
40	CSNK1G2	0.78741424
41	CSNK1G3	0.78711769
42	LMTK2	0.77485362
43	FER	0.77369051
44	VRK1	0.74778332
45	DDR2	0.71778942
46	MAPK15	0.70805514
47	WNK1	0.70147357
48	WNK4	0.65493867
49	MST4	0.65462956
50	MKNK1	0.64845632
51	TXK	0.64556602
52	PRKAA2	0.64267747
53	PDK1	0.64110366
54	AKT3	0.62081344
55	BMPR1B	0.60523812
56	CDK7	0.60176952
57	CSNK1G1	0.60040247
58	FGFR2	0.58669986
59	TESK2	0.57152326
60	JAK3	0.53018751
61	PKN1	0.51710789
62	WNK3	0.51267377
63	DYRK1B	0.50539978
64	EPHB1	0.49787199
65	STK38L	0.49669619
66	NEK9	0.49139519
67	MAP3K4	0.47736160
68	MAPKAPK5	0.45333026
69	CHEK2	0.44363861
70	ERBB3	0.40980969
71	ATM	0.39554083
72	ATR	0.37069414
73	BCR	0.36403731
74	PRKAA1	0.34575712
75	PRKG2	0.33595449
76	CAMKK2	0.33342910
77	CAMK1D	0.32651141
78	EPHA4	0.32467471
79	CDK1	0.31334609
80	DYRK2	0.31225814
81	CDK2	0.29663653
82	PRKG1	0.29266002
83	GSK3B	0.29103786
84	CSNK1A1	0.28819970
85	MAP2K7	0.28670376
86	SGK1	0.28468277
87	CHEK1	0.28052982
88	PRKCG	0.26944612
89	TIE1	0.26136476
90	PDPK1	0.25552462
91	MAPK11	0.25450926
92	CDC7	0.24057407
93	NTRK2	0.23136340
94	MAPK1	0.22516107
95	CAMK4	0.22439685
96	JAK2	0.22199786
97	CAMK1	0.21167169
98	NME2	0.21140837
99	CSNK1D	0.20694661
100	MAPK8	0.20338454

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.12055009
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.94961959
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.98338141
4	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.84559152
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.81414895
6	Olfactory transduction_Homo sapiens_hsa04740	2.64950725
7	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.36004892
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.33220728
9	Propanoate metabolism_Homo sapiens_hsa00640	2.25981696
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20323730
11	Fatty acid metabolism_Homo sapiens_hsa01212	2.14140325
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.99266928
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.96359339
14	Butanoate metabolism_Homo sapiens_hsa00650	1.95603294
15	RNA transport_Homo sapiens_hsa03013	1.92793321
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.90163986
17	Fatty acid degradation_Homo sapiens_hsa00071	1.81245686
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.75497989
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.73462979
20	Carbon metabolism_Homo sapiens_hsa01200	1.72309846
21	Taste transduction_Homo sapiens_hsa04742	1.71903032
22	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.65100755
23	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.58888373
24	Phototransduction_Homo sapiens_hsa04744	1.54461050
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.52090636
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38403175
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.33866409
28	Basal transcription factors_Homo sapiens_hsa03022	1.26191271
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.14705270
30	ABC transporters_Homo sapiens_hsa02010	1.13476088
31	Peroxisome_Homo sapiens_hsa04146	1.13354491
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12056260
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.10106965
34	Nicotine addiction_Homo sapiens_hsa05033	1.03938311
35	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.01402579
36	One carbon pool by folate_Homo sapiens_hsa00670	0.94624852
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.93008644
38	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.91807940
39	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.90616513
40	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.89828651
41	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.88678330
42	Lysine degradation_Homo sapiens_hsa00310	0.84955198
43	PPAR signaling pathway_Homo sapiens_hsa03320	0.81342321
44	Nucleotide excision repair_Homo sapiens_hsa03420	0.80239204
45	Circadian rhythm_Homo sapiens_hsa04710	0.79050770
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78751051
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75459506
48	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71912770
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.70709155
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.68514316
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65817104
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63531142
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62753632
54	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.61516748
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61422621
56	Insulin secretion_Homo sapiens_hsa04911	0.59772427
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59705349
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59319369
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55863071
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.54748400
61	Regulation of autophagy_Homo sapiens_hsa04140	0.54663858
62	RNA degradation_Homo sapiens_hsa03018	0.54083503
63	Oocyte meiosis_Homo sapiens_hsa04114	0.52654420
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.52625923
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.52597019
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52149030
67	Base excision repair_Homo sapiens_hsa03410	0.49281619
68	GABAergic synapse_Homo sapiens_hsa04727	0.48828733
69	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48758413
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.48418507
71	Morphine addiction_Homo sapiens_hsa05032	0.47611168
72	Fatty acid elongation_Homo sapiens_hsa00062	0.47348686
73	Purine metabolism_Homo sapiens_hsa00230	0.46802368
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46038805
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.41063505
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40009671
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39570015
78	Bile secretion_Homo sapiens_hsa04976	0.39486771
79	Metabolic pathways_Homo sapiens_hsa01100	0.39215768
80	Salivary secretion_Homo sapiens_hsa04970	0.38995981
81	Retinol metabolism_Homo sapiens_hsa00830	0.37171855
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36783782
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.33799289
84	Homologous recombination_Homo sapiens_hsa03440	0.32458038
85	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.31859289
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.31369325
87	Type II diabetes mellitus_Homo sapiens_hsa04930	0.30646967
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30466151
89	Renin-angiotensin system_Homo sapiens_hsa04614	0.29804122
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28280403
91	Endocytosis_Homo sapiens_hsa04144	0.28229698
92	Spliceosome_Homo sapiens_hsa03040	0.28049538
93	Huntingtons disease_Homo sapiens_hsa05016	0.27965977
94	Mineral absorption_Homo sapiens_hsa04978	0.27253552
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.26664354
96	Circadian entrainment_Homo sapiens_hsa04713	0.26164600
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.25804934
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25757627
99	mTOR signaling pathway_Homo sapiens_hsa04150	0.25749749
100	Axon guidance_Homo sapiens_hsa04360	0.25439235

GTF2IP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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