GTF2IRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.19399331
2planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99194930
3regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.74355600
4pre-miRNA processing (GO:0031054)3.73951948
5regulation of gene silencing by RNA (GO:0060966)3.53924150
6regulation of posttranscriptional gene silencing (GO:0060147)3.53924150
7regulation of gene silencing by miRNA (GO:0060964)3.53924150
8regulation of hippo signaling (GO:0035330)3.46698049
9behavioral response to nicotine (GO:0035095)3.45435087
10lateral sprouting from an epithelium (GO:0060601)3.37389650
11embryonic camera-type eye development (GO:0031076)3.32686507
12regulation of sister chromatid cohesion (GO:0007063)3.32009515
13heterochromatin organization (GO:0070828)3.29503551
14cornea development in camera-type eye (GO:0061303)3.21257208
15dosage compensation (GO:0007549)3.15792308
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13220462
17notochord development (GO:0030903)3.12553030
18nuclear pore organization (GO:0006999)3.09571916
19DNA unwinding involved in DNA replication (GO:0006268)3.08979146
20peptidyl-arginine omega-N-methylation (GO:0035247)3.07986192
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.03515038
22establishment of apical/basal cell polarity (GO:0035089)3.01406313
23spliceosomal tri-snRNP complex assembly (GO:0000244)2.99260976
24protein localization to kinetochore (GO:0034501)2.98756034
25regulation of telomere maintenance via telomerase (GO:0032210)2.95805008
26negative regulation of histone methylation (GO:0031061)2.88741791
27histone arginine methylation (GO:0034969)2.86869180
28hippo signaling (GO:0035329)2.86633534
29establishment of planar polarity (GO:0001736)2.86331192
30establishment of tissue polarity (GO:0007164)2.86331192
31polarized epithelial cell differentiation (GO:0030859)2.86290463
32regulation of stem cell maintenance (GO:2000036)2.86204666
33outer ear morphogenesis (GO:0042473)2.84474536
34mitotic sister chromatid cohesion (GO:0007064)2.84435558
35mitotic sister chromatid segregation (GO:0000070)2.81870743
36limb bud formation (GO:0060174)2.78894165
37peptidyl-arginine methylation (GO:0018216)2.78427172
38peptidyl-arginine N-methylation (GO:0035246)2.78427172
39sister chromatid segregation (GO:0000819)2.77759407
40regulation of transforming growth factor beta2 production (GO:0032909)2.76213513
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76103132
42regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.75712808
43establishment or maintenance of monopolar cell polarity (GO:0061339)2.75628626
44establishment of monopolar cell polarity (GO:0061162)2.75628626
45nuclear pore complex assembly (GO:0051292)2.75073664
46negative regulation of cell fate specification (GO:0009996)2.74000788
47cell migration in hindbrain (GO:0021535)2.73972164
48nephron epithelium morphogenesis (GO:0072088)2.73560969
49nephron tubule morphogenesis (GO:0072078)2.73560969
50mitotic nuclear envelope disassembly (GO:0007077)2.73072628
51lung-associated mesenchyme development (GO:0060484)2.72597782
52embryonic foregut morphogenesis (GO:0048617)2.72294557
53negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.70307273
54cochlea morphogenesis (GO:0090103)2.69716379
55convergent extension (GO:0060026)2.69240597
56head development (GO:0060322)2.64910242
57dorsal/ventral axis specification (GO:0009950)2.64691147
58negative regulation of axon guidance (GO:1902668)2.64338589
59pyrimidine nucleobase catabolic process (GO:0006208)2.63556663
60regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62791848
61regulation of cardioblast proliferation (GO:0003264)2.62791848
62histone H2A monoubiquitination (GO:0035518)2.60480401
63mitotic metaphase plate congression (GO:0007080)2.60143737
64positive regulation of DNA-dependent DNA replication (GO:2000105)2.59721775
65anatomical structure regression (GO:0060033)2.59339203
66negative regulation of axon extension involved in axon guidance (GO:0048843)2.58564853
67nucleosome disassembly (GO:0006337)2.58468192
68protein-DNA complex disassembly (GO:0032986)2.58468192
69primitive streak formation (GO:0090009)2.58198016
70replicative senescence (GO:0090399)2.57337056
71positive regulation of gastrulation (GO:2000543)2.57257422
72negative regulation of mRNA processing (GO:0050686)2.56468442
73hindlimb morphogenesis (GO:0035137)2.55450181
74embryonic hindlimb morphogenesis (GO:0035116)2.55058731
75gastrulation with mouth forming second (GO:0001702)2.54535431
76establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.54242204
77negative regulation of chondrocyte differentiation (GO:0032331)2.53530222
78proximal/distal pattern formation (GO:0009954)2.53253093
79nuclear envelope disassembly (GO:0051081)2.53006413
80membrane disassembly (GO:0030397)2.53006413
81intracellular estrogen receptor signaling pathway (GO:0030520)2.52934994
82regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52347615
83regulation of chromatin binding (GO:0035561)2.51774561
84regulation of helicase activity (GO:0051095)2.50908330
85Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48677855
86negative regulation of RNA splicing (GO:0033119)2.48455611
87nodal signaling pathway (GO:0038092)2.47800112
88spinal cord development (GO:0021510)2.46884414
89cell proliferation in forebrain (GO:0021846)2.46676314
90histone H2A acetylation (GO:0043968)2.46629215
91negative regulation of chromosome segregation (GO:0051985)2.46183982
92DNA duplex unwinding (GO:0032508)2.45490640
93postsynaptic membrane organization (GO:0001941)2.45126571
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.44005085
95DNA geometric change (GO:0032392)2.43457709
96cell surface receptor signaling pathway involved in heart development (GO:0061311)2.43277804
97anterior/posterior axis specification, embryo (GO:0008595)2.42930727
98regulation of axon guidance (GO:1902667)2.42534739
99regulation of mesenchymal cell apoptotic process (GO:2001053)2.42396459
100spindle assembly checkpoint (GO:0071173)2.42254593
101positive regulation of RNA splicing (GO:0033120)2.42090435
102mitotic spindle assembly checkpoint (GO:0007094)2.41309300
103regulation of establishment of planar polarity (GO:0090175)2.40102484
104metaphase plate congression (GO:0051310)2.39704981
105histone H4-K5 acetylation (GO:0043981)2.39346812
106histone H4-K8 acetylation (GO:0043982)2.39346812
107regulation of DNA damage checkpoint (GO:2000001)2.39199105
108hindbrain development (GO:0030902)2.39124702
109negative regulation of DNA repair (GO:0045738)2.38873621
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.37386467
111negative regulation of sister chromatid segregation (GO:0033046)2.37386467
112negative regulation of mitotic sister chromatid separation (GO:2000816)2.37386467
113negative regulation of mitotic sister chromatid segregation (GO:0033048)2.37386467
114non-canonical Wnt signaling pathway (GO:0035567)2.36567838
115regulation of axon extension involved in axon guidance (GO:0048841)2.36163317
116regulation of gene silencing (GO:0060968)2.35836731
117cardiac right ventricle morphogenesis (GO:0003215)2.32767438
118axon extension involved in axon guidance (GO:0048846)2.31501227
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.31501227
120axonal fasciculation (GO:0007413)2.31364295
121retinal ganglion cell axon guidance (GO:0031290)2.29532563
122presynaptic membrane assembly (GO:0097105)2.25266522
123somite development (GO:0061053)2.21108215
124negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.19921872
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.15511158
126nucleobase catabolic process (GO:0046113)2.12796957
127kidney morphogenesis (GO:0060993)2.12012595
128sympathetic nervous system development (GO:0048485)2.09145491
129calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.09055456
130response to pheromone (GO:0019236)2.07664110
131dendritic spine morphogenesis (GO:0060997)2.07620100
132dorsal/ventral neural tube patterning (GO:0021904)2.06764914
133nephron tubule formation (GO:0072079)2.05674044
134regulation of mesoderm development (GO:2000380)2.04919271
135negative regulation of astrocyte differentiation (GO:0048712)2.04486029
136midbrain development (GO:0030901)2.02792365
137body morphogenesis (GO:0010171)2.02389181
138nonmotile primary cilium assembly (GO:0035058)2.01457640
139neuron recognition (GO:0008038)2.00581099
140lung epithelium development (GO:0060428)2.00114565
141positive regulation of sodium ion transmembrane transporter activity (GO:2000651)1.99945796
142branching involved in salivary gland morphogenesis (GO:0060445)1.95683740
143embryonic body morphogenesis (GO:0010172)1.94934832
144neuron fate specification (GO:0048665)1.94787589
145positive regulation of fatty acid oxidation (GO:0046321)1.94525447
146synapse assembly (GO:0007416)1.94344220
147L-serine metabolic process (GO:0006563)1.93610557
148positive regulation of embryonic development (GO:0040019)1.91785797
149limb development (GO:0060173)1.91075037
150appendage development (GO:0048736)1.91075037
151embryonic retina morphogenesis in camera-type eye (GO:0060059)1.90867259
152urinary tract smooth muscle contraction (GO:0014848)1.89783194
153myoblast fusion (GO:0007520)1.89404572
154dopaminergic neuron differentiation (GO:0071542)1.88889453
155mesenchymal to epithelial transition (GO:0060231)1.88755303
156neuromuscular synaptic transmission (GO:0007274)1.87007740
157peristalsis (GO:0030432)1.86737010
158pattern specification involved in kidney development (GO:0061004)1.86657950
159G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.85591449
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.84807328
161positive regulation of fatty acid beta-oxidation (GO:0032000)1.84020803
162cranial nerve morphogenesis (GO:0021602)1.83852968
163presynaptic membrane organization (GO:0097090)1.83836167
164collecting duct development (GO:0072044)1.82720153
165growth hormone secretion (GO:0030252)1.82523701
166cellular response to cholesterol (GO:0071397)1.81647592
167mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.80802423
168positive regulation of sodium ion transmembrane transport (GO:1902307)1.80493685
169positive regulation of smoothened signaling pathway (GO:0045880)1.79403794
170urogenital system development (GO:0001655)1.79343550
171renal tubule morphogenesis (GO:0061333)1.79076792
172positive regulation of mesonephros development (GO:0061213)1.77263767
173embryonic forelimb morphogenesis (GO:0035115)1.77221590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60456474
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42688856
3TP63_19390658_ChIP-ChIP_HaCaT_Human4.12127217
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.18945960
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.13539760
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.09513570
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.07915856
8EZH2_22144423_ChIP-Seq_EOC_Human2.77254152
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.72668866
10ZNF274_21170338_ChIP-Seq_K562_Hela2.70638019
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69655213
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67272067
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.63361906
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55641667
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.54755723
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.46077312
17SOX2_18555785_ChIP-Seq_MESCs_Mouse2.40101342
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32520506
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32520506
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32520506
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31376614
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.26370681
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.23238011
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.12000173
25ESR1_15608294_ChIP-ChIP_MCF-7_Human2.09581238
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.08945060
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.07241729
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02283470
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.99429097
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.98922842
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97950066
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97089842
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93369323
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.91036576
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.90181194
36POU5F1_16518401_ChIP-PET_MESCs_Mouse1.84411931
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82041023
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.79718483
39AR_21909140_ChIP-Seq_LNCAP_Human1.70998020
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66907255
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65413287
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.65260894
43VDR_22108803_ChIP-Seq_LS180_Human1.63200787
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.61969846
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61879989
46MYC_22102868_ChIP-Seq_BL_Human1.60472777
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.57815763
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57641974
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.57105268
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.57072420
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56259772
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55845977
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55461947
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55111357
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53496104
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53358042
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53352920
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51440513
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50167251
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.49844010
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48880370
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48632854
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47112766
64TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.46418512
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46280395
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46280395
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44853051
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43930851
69CIITA_25753668_ChIP-Seq_RAJI_Human1.43401892
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40038418
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39966055
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37963957
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36198735
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35545296
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35115000
76* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33624539
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.30986921
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29654610
79RNF2_27304074_Chip-Seq_NSC_Mouse1.29479701
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.28569705
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26774595
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.26349654
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25725071
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25685204
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25582178
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24969727
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.24296397
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23715082
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23705139
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23215937
91REST_21632747_ChIP-Seq_MESCs_Mouse1.21986499
92* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21654880
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20813456
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19818684
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19227374
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19104218
97XRN2_22483619_ChIP-Seq_HELA_Human1.17043351
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16055253
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.14845862
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14632047
101* GBX2_23144817_ChIP-Seq_PC3_Human1.13288221
102CTCF_27219007_Chip-Seq_Bcells_Human1.13279520
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.13253674
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10689110
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09888974
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09249092
107SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08792993
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08388622
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07644638
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07264723
111MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06391288
112* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06057661
113MYC_18940864_ChIP-ChIP_HL60_Human1.03974651
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03585162
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03408158
116PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02646362
117DROSHA_22980978_ChIP-Seq_HELA_Human1.01488942
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00794776
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00790411
120POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00390295
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.00041440
122NANOG_16518401_ChIP-PET_MESCs_Mouse0.99166550
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99001836
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98930960
125* ESR2_21235772_ChIP-Seq_MCF-7_Human0.98239429
126SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98209901
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96855429
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96461680
129FUS_26573619_Chip-Seq_HEK293_Human0.95727031
130TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94582896
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.94048374
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93840084
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93555470
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93426793
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92998914
136HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91722095
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91617052
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91548822
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91337341
140AHR_22903824_ChIP-Seq_MCF-7_Human0.90967376
141* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90931812
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90874921
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88976052
144* KAP1_27257070_Chip-Seq_ESCs_Mouse0.88858599
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88631455
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88446236
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88275624
148SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88027965
149MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87769150
150ZNF263_19887448_ChIP-Seq_K562_Human0.86922479
151SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85869395
152* ATF3_27146783_Chip-Seq_COLON_Human0.85645330
153EWS_26573619_Chip-Seq_HEK293_Human0.82916538
154GATA1_26923725_Chip-Seq_HPCs_Mouse0.82306503
155* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82108133
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81831676
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81831676
158AR_21572438_ChIP-Seq_LNCaP_Human0.81368544
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80755284
160ETS1_20019798_ChIP-Seq_JURKAT_Human0.80041577
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79173869
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.78838144
163ER_23166858_ChIP-Seq_MCF-7_Human0.78829537
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78720919
165* ERA_21632823_ChIP-Seq_H3396_Human0.78431400
166FOXP1_21924763_ChIP-Seq_HESCs_Human0.78425620
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78358308
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77026666
169AR_19668381_ChIP-Seq_PC3_Human0.75600740
170* HOXB7_26014856_ChIP-Seq_BT474_Human0.73662227
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.73397065
172* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.70778172
173TP53_23651856_ChIP-Seq_MEFs_Mouse0.70240324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010030_abnormal_orbit_morphology3.88398318
2MP0002653_abnormal_ependyma_morphology2.82595170
3MP0000537_abnormal_urethra_morphology2.40301080
4MP0003121_genomic_imprinting2.37544698
5MP0000566_synostosis2.33137960
6MP0003123_paternal_imprinting2.32116205
7MP0008789_abnormal_olfactory_epithelium2.27174337
8MP0003890_abnormal_embryonic-extraembry2.22260753
9MP0006292_abnormal_olfactory_placode2.16616452
10MP0003122_maternal_imprinting2.14838957
11MP0003111_abnormal_nucleus_morphology2.07808335
12MP0009053_abnormal_anal_canal2.02737529
13MP0003705_abnormal_hypodermis_morpholog1.99685446
14MP0005394_taste/olfaction_phenotype1.94339498
15MP0005499_abnormal_olfactory_system1.94339498
16MP0003119_abnormal_digestive_system1.90933066
17MP0003941_abnormal_skin_development1.86385617
18MP0001293_anophthalmia1.83660998
19MP0003385_abnormal_body_wall1.79459668
20MP0002249_abnormal_larynx_morphology1.75644338
21MP0010094_abnormal_chromosome_stability1.72121375
22MP0005248_abnormal_Harderian_gland1.71550796
23MP0000049_abnormal_middle_ear1.66518422
24MP0003136_yellow_coat_color1.62241060
25MP0003077_abnormal_cell_cycle1.62206478
26MP0003937_abnormal_limbs/digits/tail_de1.61150657
27MP0008007_abnormal_cellular_replicative1.59821314
28MP0002233_abnormal_nose_morphology1.55990567
29MP0003755_abnormal_palate_morphology1.55299891
30* MP0002085_abnormal_embryonic_tissue1.54456327
31MP0010352_gastrointestinal_tract_polyps1.53087014
32MP0003942_abnormal_urinary_system1.52874297
33MP0003878_abnormal_ear_physiology1.51497674
34MP0005377_hearing/vestibular/ear_phenot1.51497674
35MP0002932_abnormal_joint_morphology1.51190970
36MP0004145_abnormal_muscle_electrophysio1.50711014
37MP0000383_abnormal_hair_follicle1.49913942
38MP0001849_ear_inflammation1.49851596
39MP0000778_abnormal_nervous_system1.49725890
40MP0002084_abnormal_developmental_patter1.49622920
41MP0004957_abnormal_blastocyst_morpholog1.48321712
42* MP0003935_abnormal_craniofacial_develop1.48192725
43MP0003693_abnormal_embryo_hatching1.44480687
44MP0004197_abnormal_fetal_growth/weight/1.42546381
45MP0003115_abnormal_respiratory_system1.42509481
46MP0004133_heterotaxia1.42241332
47MP0002234_abnormal_pharynx_morphology1.41107169
48MP0003283_abnormal_digestive_organ1.37748433
49MP0002697_abnormal_eye_size1.37151781
50MP0001286_abnormal_eye_development1.35608082
51MP0003787_abnormal_imprinting1.35289730
52MP0002184_abnormal_innervation1.35260824
53MP0000350_abnormal_cell_proliferation1.33347197
54MP0000534_abnormal_ureter_morphology1.32948975
55MP0001730_embryonic_growth_arrest1.30316705
56MP0005076_abnormal_cell_differentiation1.29584686
57MP0006072_abnormal_retinal_apoptosis1.29399886
58* MP0001672_abnormal_embryogenesis/_devel1.28773894
59* MP0005380_embryogenesis_phenotype1.28773894
60MP0002092_abnormal_eye_morphology1.27683075
61MP0003938_abnormal_ear_development1.27646653
62MP0000427_abnormal_hair_cycle1.27155300
63MP0001299_abnormal_eye_distance/1.26643551
64* MP0002116_abnormal_craniofacial_bone1.25580974
65* MP0000428_abnormal_craniofacial_morphol1.24524798
66MP0000762_abnormal_tongue_morphology1.24420692
67MP0004233_abnormal_muscle_weight1.22836438
68MP0005367_renal/urinary_system_phenotyp1.22048396
69MP0000516_abnormal_urinary_system1.22048396
70MP0002111_abnormal_tail_morphology1.21261988
71MP0000678_abnormal_parathyroid_gland1.21157505
72MP0009780_abnormal_chondrocyte_physiolo1.20765909
73MP0003567_abnormal_fetal_cardiomyocyte1.19480054
74MP0005187_abnormal_penis_morphology1.19436380
75MP0009250_abnormal_appendicular_skeleto1.19019045
76MP0010234_abnormal_vibrissa_follicle1.18491393
77* MP0000432_abnormal_head_morphology1.16076016
78* MP0003861_abnormal_nervous_system1.15375796
79MP0000026_abnormal_inner_ear1.13213315
80MP0000733_abnormal_muscle_development1.12558339
81MP0004885_abnormal_endolymph1.12115982
82* MP0002088_abnormal_embryonic_growth/wei1.11928227
83MP0009703_decreased_birth_body1.11715260
84* MP0003984_embryonic_growth_retardation1.11462603
85MP0003315_abnormal_perineum_morphology1.11297579
86* MP0001697_abnormal_embryo_size1.10451269
87MP0002751_abnormal_autonomic_nervous1.10137467
88MP0005391_vision/eye_phenotype1.08356639
89MP0002282_abnormal_trachea_morphology1.07746208
90MP0008932_abnormal_embryonic_tissue1.07696943
91* MP0002086_abnormal_extraembryonic_tissu1.06497599
92MP0001984_abnormal_olfaction1.06313024
93MP0005275_abnormal_skin_tensile1.05509479
94MP0005551_abnormal_eye_electrophysiolog1.05056540
95* MP0002938_white_spotting1.04028215
96MP0004264_abnormal_extraembryonic_tissu1.03360649
97MP0010678_abnormal_skin_adnexa1.02877465
98MP0002102_abnormal_ear_morphology1.01224490
99MP0002098_abnormal_vibrissa_morphology1.00117942
100MP0009672_abnormal_birth_weight0.99681994
101MP0005508_abnormal_skeleton_morphology0.99448827
102MP0008058_abnormal_DNA_repair0.99138782
103MP0001346_abnormal_lacrimal_gland0.99088929
104MP0000579_abnormal_nail_morphology0.98536013
105MP0002752_abnormal_somatic_nervous0.98146227
106MP0005503_abnormal_tendon_morphology0.98111149
107MP0003137_abnormal_impulse_conducting0.97915538
108MP0000955_abnormal_spinal_cord0.97426830
109MP0002822_catalepsy0.95239674
110MP0002837_dystrophic_cardiac_calcinosis0.95122829
111MP0000462_abnormal_digestive_system0.95115870
112MP0008057_abnormal_DNA_replication0.95067194
113MP0001502_abnormal_circadian_rhythm0.94972170
114MP0003646_muscle_fatigue0.94244597
115MP0002089_abnormal_postnatal_growth/wei0.91179213
116MP0005623_abnormal_meninges_morphology0.90845271
117MP0001529_abnormal_vocalization0.89888792
118MP0000647_abnormal_sebaceous_gland0.89773649
119MP0009046_muscle_twitch0.89733372
120* MP0002114_abnormal_axial_skeleton0.87661680
121MP0005257_abnormal_intraocular_pressure0.87487342
122MP0000631_abnormal_neuroendocrine_gland0.87274484
123MP0001485_abnormal_pinna_reflex0.87051703
124* MP0002080_prenatal_lethality0.86388602
125MP0002109_abnormal_limb_morphology0.86051055
126MP0004142_abnormal_muscle_tone0.85359881
127MP0002108_abnormal_muscle_morphology0.85182728
128MP0000538_abnormal_urinary_bladder0.84804899
129MP0004272_abnormal_basement_membrane0.83899693
130MP0008877_abnormal_DNA_methylation0.83269546
131* MP0002557_abnormal_social/conspecific_i0.82832992
132MP0002638_abnormal_pupillary_reflex0.81483305
133MP0004270_analgesia0.81355659
134MP0002160_abnormal_reproductive_system0.81178005
135MP0002734_abnormal_mechanical_nocicepti0.80699205
136MP0005195_abnormal_posterior_eye0.80399553
137MP0004043_abnormal_pH_regulation0.79937333
138MP0000751_myopathy0.79300598
139MP0004858_abnormal_nervous_system0.79129298
140MP0002882_abnormal_neuron_morphology0.79100615
141* MP0002152_abnormal_brain_morphology0.78730935
142MP0000750_abnormal_muscle_regeneration0.78064554
143MP0009384_cardiac_valve_regurgitation0.75523665
144MP0000749_muscle_degeneration0.75095171
145MP0000013_abnormal_adipose_tissue0.73510824
146MP0002177_abnormal_outer_ear0.72785065
147MP0004742_abnormal_vestibular_system0.71696313
148MP0003011_delayed_dark_adaptation0.71273514
149* MP0002572_abnormal_emotion/affect_behav0.71064733

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.53985204
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.53985204
3Abnormality of the 4th metacarpal (HP:0010012)2.88321559
4* Renal duplication (HP:0000075)2.87436280
5Pendular nystagmus (HP:0012043)2.79837917
6Selective tooth agenesis (HP:0001592)2.75906251
7Medulloblastoma (HP:0002885)2.70651476
8Abdominal situs inversus (HP:0003363)2.69143944
9Abnormality of abdominal situs (HP:0011620)2.69143944
10Concave nail (HP:0001598)2.53298356
11Molar tooth sign on MRI (HP:0002419)2.51701241
12Abnormality of midbrain morphology (HP:0002418)2.51701241
13Ependymoma (HP:0002888)2.50535785
14Type II lissencephaly (HP:0007260)2.49455328
15Nephronophthisis (HP:0000090)2.48031732
16Abnormality of the labia minora (HP:0012880)2.43683497
17High anterior hairline (HP:0009890)2.37985097
18Astrocytoma (HP:0009592)2.36764432
19Abnormality of the astrocytes (HP:0100707)2.36764432
20Tubular atrophy (HP:0000092)2.35920312
21Shawl scrotum (HP:0000049)2.32770091
22Cerebellar dysplasia (HP:0007033)2.30321287
23Shallow orbits (HP:0000586)2.30032354
24Neoplasm of the oral cavity (HP:0100649)2.29997494
25Abnormal number of incisors (HP:0011064)2.29360450
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25344210
27Glioma (HP:0009733)2.23184334
28* Increased nuchal translucency (HP:0010880)2.20907561
29Chorioretinal atrophy (HP:0000533)2.19390697
30Pancreatic cysts (HP:0001737)2.19045037
31Colon cancer (HP:0003003)2.17194370
32Hypoplastic labia majora (HP:0000059)2.14355136
33Patellar aplasia (HP:0006443)2.14023256
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13818524
35Pancreatic fibrosis (HP:0100732)2.12033159
36Aplasia/Hypoplasia of the patella (HP:0006498)2.11279764
37Mesomelia (HP:0003027)2.10837074
38Abnormality of the renal medulla (HP:0100957)2.08610678
39* Renovascular hypertension (HP:0100817)2.08126190
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.07726380
41Abnormality of the parietal bone (HP:0002696)2.07440572
42Short phalanx of the thumb (HP:0009660)2.04796236
43Trigonocephaly (HP:0000243)2.04576817
44Abnormality of the labia majora (HP:0012881)2.02921069
45* Hyperacusis (HP:0010780)2.01039678
46Neoplasm of striated muscle (HP:0009728)2.00749335
47Chromsome breakage (HP:0040012)1.99657286
48Skull defect (HP:0001362)1.97724571
49True hermaphroditism (HP:0010459)1.97272500
50Ectopic kidney (HP:0000086)1.96006871
51Protrusio acetabuli (HP:0003179)1.95813714
52Cystic liver disease (HP:0006706)1.92798617
53Atresia of the external auditory canal (HP:0000413)1.92417355
54Long eyelashes (HP:0000527)1.90143036
55Renal dysplasia (HP:0000110)1.89533117
56Lissencephaly (HP:0001339)1.89441601
57Unilateral renal agenesis (HP:0000122)1.88025824
58Sclerocornea (HP:0000647)1.86356851
59Bronchomalacia (HP:0002780)1.85771759
60Partial agenesis of the corpus callosum (HP:0001338)1.85050535
61Abnormality of the aortic arch (HP:0012303)1.84394514
62Supernumerary ribs (HP:0005815)1.84325439
63Septo-optic dysplasia (HP:0100842)1.84257539
64Pseudobulbar signs (HP:0002200)1.83145958
65Midline defect of the nose (HP:0004122)1.82128365
66Hypoplastic ischia (HP:0003175)1.81292626
67Anophthalmia (HP:0000528)1.81273321
68Hyperventilation (HP:0002883)1.80627300
69Broad thumb (HP:0011304)1.80568105
70Bony spicule pigmentary retinopathy (HP:0007737)1.78033872
71Rib fusion (HP:0000902)1.77852449
72Occipital encephalocele (HP:0002085)1.77735269
73Retinal dysplasia (HP:0007973)1.76607671
74Hypoplasia of the maxilla (HP:0000327)1.76507743
75Bilateral microphthalmos (HP:0007633)1.76122953
76Wrist flexion contracture (HP:0001239)1.75831364
77Short 5th finger (HP:0009237)1.75243892
78Chronic hepatic failure (HP:0100626)1.75035023
79Optic nerve hypoplasia (HP:0000609)1.74194814
80Abnormality of the phalanges of the hallux (HP:0010057)1.73388997
81Deviation of the thumb (HP:0009603)1.73248823
82* Elfin facies (HP:0004428)1.72559182
83Volvulus (HP:0002580)1.72059180
84* Spina bifida occulta (HP:0003298)1.71919846
85Alopecia of scalp (HP:0002293)1.71183379
86Proximal placement of thumb (HP:0009623)1.70095096
87Flat capital femoral epiphysis (HP:0003370)1.69916769
88Hypoplasia of the pons (HP:0012110)1.69628333
89Broad toe (HP:0001837)1.69301029
90Supernumerary bones of the axial skeleton (HP:0009144)1.69068192
91Esophageal atresia (HP:0002032)1.69028717
92Congenital stationary night blindness (HP:0007642)1.68255788
93Short middle phalanx of the 5th finger (HP:0004220)1.67549813
94Skin tags (HP:0010609)1.67415865
95* Bowel diverticulosis (HP:0005222)1.66737843
96Rhabdomyosarcoma (HP:0002859)1.66550151
97Atrophic scars (HP:0001075)1.66238478
98Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.65949099
99Milia (HP:0001056)1.64773888
100Hemivertebrae (HP:0002937)1.64592478
101Absent radius (HP:0003974)1.64025380
102Broad-based gait (HP:0002136)1.62118174
103Septate vagina (HP:0001153)1.62060526
104Severe muscular hypotonia (HP:0006829)1.61354108
105Neoplasm of the heart (HP:0100544)1.61166618
106Birth length less than 3rd percentile (HP:0003561)1.60726844
107Anal stenosis (HP:0002025)1.60611436
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60581328
109Pterygium (HP:0001059)1.60030064
110Hepatoblastoma (HP:0002884)1.59845637
111Labial hypoplasia (HP:0000066)1.59536717
112Abnormality of the labia (HP:0000058)1.58641630
113Scotoma (HP:0000575)1.58230183
114Absent forearm bone (HP:0003953)1.58197954
115Aplasia involving forearm bones (HP:0009822)1.58197954
116Broad finger (HP:0001500)1.57840046
117Abnormality of the pubic bones (HP:0003172)1.57628432
118Abnormality of the ileum (HP:0001549)1.57428966
119Abnormality of the ischium (HP:0003174)1.57148284
120Cutaneous syndactyly (HP:0012725)1.57048614
121Genetic anticipation (HP:0003743)1.56755581
122Abnormality of the pons (HP:0007361)1.56722051
123Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56428699
124Abnormality of the renal cortex (HP:0011035)1.55989677
125Increased corneal curvature (HP:0100692)1.55815208
126Keratoconus (HP:0000563)1.55815208
127Short humerus (HP:0005792)1.54796741
128Cutaneous finger syndactyly (HP:0010554)1.54155053
129* Megalocornea (HP:0000485)1.53590682
130Posterior subcapsular cataract (HP:0007787)1.53387591
131Short 1st metacarpal (HP:0010034)1.53370314
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53370314
133Meckel diverticulum (HP:0002245)1.52856057
134Breast hypoplasia (HP:0003187)1.52178881
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.52046404
136Broad phalanges of the hand (HP:0009768)1.51817850
137Morphological abnormality of the middle ear (HP:0008609)1.51808395
138Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.51613252
139Hypoplastic female external genitalia (HP:0012815)1.51144530
140Anterior segment dysgenesis (HP:0007700)1.49651250
141Breech presentation (HP:0001623)1.49219348
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.49086166
143Papillary thyroid carcinoma (HP:0002895)1.49075189
144Calf muscle hypertrophy (HP:0008981)1.48190958
145Preaxial foot polydactyly (HP:0001841)1.47612412
146Maternal diabetes (HP:0009800)1.47252202
147Ulnar claw (HP:0001178)1.46843505
148Scrotal hypoplasia (HP:0000046)1.46191135
149Preaxial hand polydactyly (HP:0001177)1.44333390
150Large for gestational age (HP:0001520)1.43164212
151Aplasia of the musculature (HP:0100854)1.41937626
152Anencephaly (HP:0002323)1.41469612
153Pachygyria (HP:0001302)1.41045832
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40759148
155Absent epiphyses (HP:0010577)1.40759148
156Muscle hypertrophy of the lower extremities (HP:0008968)1.38695696
157Absent septum pellucidum (HP:0001331)1.38290231
158Hypoplasia of the capital femoral epiphysis (HP:0003090)1.37260165
159Protruding tongue (HP:0010808)1.37215695
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.36401032
161Short thumb (HP:0009778)1.35747326
162Renal hypoplasia (HP:0000089)1.35354824
163Abnormality of alanine metabolism (HP:0010916)1.35142776
164Hyperalaninemia (HP:0003348)1.35142776
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.35142776
166Gait imbalance (HP:0002141)1.34332926
167Medial flaring of the eyebrow (HP:0010747)1.33438909
168Abnormality of the 1st metacarpal (HP:0010009)1.32666176
169Dandy-Walker malformation (HP:0001305)1.32338135
170Postaxial hand polydactyly (HP:0001162)1.31830527
171* Overriding aorta (HP:0002623)1.31590897
172Bicornuate uterus (HP:0000813)1.31038567
173Coronal craniosynostosis (HP:0004440)1.29219998
174Fibular hypoplasia (HP:0003038)1.28826043
175Postaxial foot polydactyly (HP:0001830)1.28168711
176Micropenis (HP:0000054)1.27486011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.54441541
2LATS12.95905865
3CDK122.90480810
4PASK2.86382463
5MAP3K102.75962041
6CASK2.59620971
7MARK12.49412398
8BRD42.42391473
9STK38L2.41954734
10WNK42.34010936
11LATS22.19341487
12CDC72.16750133
13PHKG12.15358022
14PHKG22.15358022
15TTK2.13477536
16RIPK12.10775046
17EPHB22.09787528
18EEF2K1.99161019
19FRK1.83952448
20WNK31.82698467
21PAK41.82156205
22RPS6KB21.81244653
23PKN21.80640032
24SRPK11.79840153
25MST1R1.78553730
26NEK21.77720300
27PDGFRA1.74698465
28ICK1.74203552
29MAPKAPK31.67306977
30MUSK1.65597215
31MKNK21.65308515
32MKNK11.65253902
33NTRK31.64467202
34MET1.63485424
35DDR21.61490688
36TLK11.55624502
37CDK71.51897843
38NEK11.50012120
39NME11.49756361
40PNCK1.44874963
41TRIB31.44375726
42ATR1.35384248
43ERBB31.34542815
44TGFBR11.33715821
45OBSCN1.32207602
46ERBB21.31428717
47SIK31.30829729
48CDK81.28054304
49SIK11.27290453
50TAOK21.27227187
51MTOR1.26279378
52FGFR11.23247409
53MAPK151.19068817
54PLK11.18003554
55KSR11.15271423
56CHEK21.14623709
57TNIK1.14196498
58ACVR1B1.10769238
59ADRBK21.09768730
60EPHA41.08919308
61PLK31.08461746
62STK391.08129368
63WEE11.07853493
64PINK11.06004964
65AKT21.05632011
66CDK61.03138968
67CHEK10.99571340
68TYRO30.99196930
69CAMK1D0.96448963
70LIMK10.96195311
71BUB10.94902847
72STK30.91367907
73FLT30.90901104
74TAF10.90383740
75INSRR0.90255399
76AURKB0.89636193
77LMTK20.85246939
78GRK10.85200200
79PRKAA10.84095910
80CSNK1G10.83426887
81CDK40.82864300
82CDK20.82460525
83VRK20.81996903
84MAP2K70.81816564
85CSNK1G30.81211666
86FGFR20.79613173
87CDK90.79475440
88DYRK20.79075992
89PTK60.78705063
90ATM0.78278119
91PAK30.77568996
92FER0.77371962
93PRKCG0.76623343
94PLK40.76612009
95ALK0.76083627
96ERBB40.74047939
97MAP3K60.72119105
98AKT30.71344412
99CSNK1G20.70421121
100NTRK20.69099165
101BMPR1B0.68897537
102DYRK30.68413577
103NTRK10.66700603
104TSSK60.65473144
105CDK10.63511145
106PRKD30.61805108
107STK380.61715438
108DYRK1B0.58518803
109MELK0.57991761
110SIK20.57620522
111MAP3K90.57165573
112BRSK10.57031576
113PIK3CA0.56412888
114PRPF4B0.56232625
115MAP4K20.56230627
116BMX0.54996780
117BRSK20.54543250
118AKT10.53676181
119MAP3K80.53329972
120AURKA0.52214634
121CAMK1G0.51706403
122CSNK1A1L0.50898682
123MAP2K20.50863764
124PAK20.49625939
125TTN0.49091112
126MAPK90.48587189
127PRKCE0.48461998
128CSNK1E0.47208557
129CSNK1D0.47077734
130* MAPK140.46528240
131MAP2K10.46213806
132* GSK3B0.46160319
133CDC42BPA0.46084395
134PTK20.45878443
135CAMK2G0.44501257
136MAPK10.44480221
137RPS6KA20.43815171
138RPS6KA10.43162060
139PRKCI0.42936084
140PRKD20.42206529
141MAP2K40.42075281
142MAPK130.41397244
143ADRBK10.40850807
144CSNK1A10.39728722
145VRK10.39263079
146MAP3K40.38676486
147BCKDK0.38346280
148MAPKAPK50.38251082
149DAPK20.37935083
150ZAK0.37544921
151PRKDC0.37127323
152UHMK10.36345458

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.65001691
2Cell cycle_Homo sapiens_hsa041102.75971403
3Hedgehog signaling pathway_Homo sapiens_hsa043402.73786251
4One carbon pool by folate_Homo sapiens_hsa006702.57693620
5Hippo signaling pathway_Homo sapiens_hsa043902.53726872
6RNA transport_Homo sapiens_hsa030132.47950859
7Spliceosome_Homo sapiens_hsa030402.45481021
8Mismatch repair_Homo sapiens_hsa034302.43989517
9DNA replication_Homo sapiens_hsa030302.37312939
10mRNA surveillance pathway_Homo sapiens_hsa030152.35821600
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.31445619
12Base excision repair_Homo sapiens_hsa034102.15096035
13Notch signaling pathway_Homo sapiens_hsa043302.14984611
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90764628
15Adherens junction_Homo sapiens_hsa045201.88965107
16Sulfur relay system_Homo sapiens_hsa041221.88115023
17Lysine degradation_Homo sapiens_hsa003101.82334230
18RNA degradation_Homo sapiens_hsa030181.78413130
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75415224
20MicroRNAs in cancer_Homo sapiens_hsa052061.74413092
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.69076058
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.66839020
23Cardiac muscle contraction_Homo sapiens_hsa042601.65998537
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62784104
25Endometrial cancer_Homo sapiens_hsa052131.57823643
26Fanconi anemia pathway_Homo sapiens_hsa034601.57802072
27Nitrogen metabolism_Homo sapiens_hsa009101.57611002
28Phototransduction_Homo sapiens_hsa047441.57119784
29Wnt signaling pathway_Homo sapiens_hsa043101.56815466
30TGF-beta signaling pathway_Homo sapiens_hsa043501.54881033
31Nucleotide excision repair_Homo sapiens_hsa034201.51440340
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46562515
33p53 signaling pathway_Homo sapiens_hsa041151.42899303
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41809435
35Butanoate metabolism_Homo sapiens_hsa006501.37193997
36Colorectal cancer_Homo sapiens_hsa052101.35524203
37Homologous recombination_Homo sapiens_hsa034401.35502928
38Bladder cancer_Homo sapiens_hsa052191.34405024
39Oxidative phosphorylation_Homo sapiens_hsa001901.34180008
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33901268
41Nicotine addiction_Homo sapiens_hsa050331.29309970
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27772686
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27132735
44Steroid biosynthesis_Homo sapiens_hsa001001.27119767
45Tight junction_Homo sapiens_hsa045301.21318341
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.21283442
47mTOR signaling pathway_Homo sapiens_hsa041501.17309382
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17273228
49Huntingtons disease_Homo sapiens_hsa050161.16000076
50Small cell lung cancer_Homo sapiens_hsa052221.13851056
51Biosynthesis of amino acids_Homo sapiens_hsa012301.13047165
52Linoleic acid metabolism_Homo sapiens_hsa005911.13012850
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12452481
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12346871
55Melanoma_Homo sapiens_hsa052181.11398764
56Vitamin B6 metabolism_Homo sapiens_hsa007501.09931762
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09867200
58Proteoglycans in cancer_Homo sapiens_hsa052051.09657251
59Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08246461
60Pathways in cancer_Homo sapiens_hsa052001.08065252
61Circadian rhythm_Homo sapiens_hsa047101.07459154
62HTLV-I infection_Homo sapiens_hsa051661.06466528
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06320311
64Insulin secretion_Homo sapiens_hsa049111.05994024
65Parkinsons disease_Homo sapiens_hsa050121.05675394
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04855555
67Chronic myeloid leukemia_Homo sapiens_hsa052201.03910275
68Ribosome_Homo sapiens_hsa030101.00032783
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99133735
70Taste transduction_Homo sapiens_hsa047420.97831142
71Thyroid cancer_Homo sapiens_hsa052160.97513311
72Oocyte meiosis_Homo sapiens_hsa041140.97206892
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94123022
74ECM-receptor interaction_Homo sapiens_hsa045120.93817378
75Melanogenesis_Homo sapiens_hsa049160.90780095
76Alzheimers disease_Homo sapiens_hsa050100.88354234
77Tryptophan metabolism_Homo sapiens_hsa003800.87227791
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86750932
79Selenocompound metabolism_Homo sapiens_hsa004500.85434558
80Ether lipid metabolism_Homo sapiens_hsa005650.85300310
81Glutamatergic synapse_Homo sapiens_hsa047240.83581328
82Axon guidance_Homo sapiens_hsa043600.81988694
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81822589
84Arginine and proline metabolism_Homo sapiens_hsa003300.81469771
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81096706
86Non-homologous end-joining_Homo sapiens_hsa034500.80042735
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78744161
88* Basal transcription factors_Homo sapiens_hsa030220.76903974
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76470984
90Focal adhesion_Homo sapiens_hsa045100.74607617
91Fructose and mannose metabolism_Homo sapiens_hsa000510.74016162
92Prostate cancer_Homo sapiens_hsa052150.73859430
93Arginine biosynthesis_Homo sapiens_hsa002200.72467454
94Circadian entrainment_Homo sapiens_hsa047130.71596389
95Propanoate metabolism_Homo sapiens_hsa006400.71122483
96Pyrimidine metabolism_Homo sapiens_hsa002400.70421346
97Protein export_Homo sapiens_hsa030600.69781737
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69676418
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69498951
100Galactose metabolism_Homo sapiens_hsa000520.68277058
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67474523
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67101566
103Non-small cell lung cancer_Homo sapiens_hsa052230.66760906
104Thyroid hormone synthesis_Homo sapiens_hsa049180.65592428
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65567702
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65482185
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.63735300
108ABC transporters_Homo sapiens_hsa020100.62838444
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62527992
110RNA polymerase_Homo sapiens_hsa030200.62459671
111Protein digestion and absorption_Homo sapiens_hsa049740.62115104
112Dopaminergic synapse_Homo sapiens_hsa047280.61639187
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60481434
114Pyruvate metabolism_Homo sapiens_hsa006200.60053205
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.59982999
116GABAergic synapse_Homo sapiens_hsa047270.59918277
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58748223
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.58699141
119Cocaine addiction_Homo sapiens_hsa050300.58679181
120Viral carcinogenesis_Homo sapiens_hsa052030.57346495
121HIF-1 signaling pathway_Homo sapiens_hsa040660.57129186
122beta-Alanine metabolism_Homo sapiens_hsa004100.56453442
123Ovarian steroidogenesis_Homo sapiens_hsa049130.56155050
124AMPK signaling pathway_Homo sapiens_hsa041520.55909724
125Metabolic pathways_Homo sapiens_hsa011000.55826936
126ErbB signaling pathway_Homo sapiens_hsa040120.55633475
127FoxO signaling pathway_Homo sapiens_hsa040680.54628999
128Glucagon signaling pathway_Homo sapiens_hsa049220.53310248
129Morphine addiction_Homo sapiens_hsa050320.52657985
130Sulfur metabolism_Homo sapiens_hsa009200.52203717
131Insulin signaling pathway_Homo sapiens_hsa049100.51489775
132Serotonergic synapse_Homo sapiens_hsa047260.51425979
133Carbon metabolism_Homo sapiens_hsa012000.50925575
134Folate biosynthesis_Homo sapiens_hsa007900.50656591
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48926974
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47133333
137Rap1 signaling pathway_Homo sapiens_hsa040150.46762240
138Dorso-ventral axis formation_Homo sapiens_hsa043200.45014257
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44186463
140Gap junction_Homo sapiens_hsa045400.43964343
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43956284
142Bile secretion_Homo sapiens_hsa049760.43754909
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43334500
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39626863
145Glioma_Homo sapiens_hsa052140.39039823
146Retinol metabolism_Homo sapiens_hsa008300.38859756
147Fat digestion and absorption_Homo sapiens_hsa049750.38724025
148Purine metabolism_Homo sapiens_hsa002300.36607825
149Alcoholism_Homo sapiens_hsa050340.36273572
150GnRH signaling pathway_Homo sapiens_hsa049120.35418304
151Dilated cardiomyopathy_Homo sapiens_hsa054140.34887930
152Acute myeloid leukemia_Homo sapiens_hsa052210.33600407
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32326016
154Pancreatic cancer_Homo sapiens_hsa052120.30055228
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28608874
156Renal cell carcinoma_Homo sapiens_hsa052110.28460835
157Insulin resistance_Homo sapiens_hsa049310.26044408

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