GTF3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.07335631
2DNA deamination (GO:0045006)5.51025860
3viral transcription (GO:0019083)5.36508578
4translational termination (GO:0006415)5.21999415
5DNA strand elongation involved in DNA replication (GO:0006271)5.21163223
6DNA strand elongation (GO:0022616)4.95689350
7telomere maintenance via semi-conservative replication (GO:0032201)4.91954580
8maturation of SSU-rRNA (GO:0030490)4.82635219
9translational elongation (GO:0006414)4.75539439
10ribosomal small subunit biogenesis (GO:0042274)4.73906397
11DNA unwinding involved in DNA replication (GO:0006268)4.68496652
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.63651087
13DNA replication initiation (GO:0006270)4.53976631
14protein targeting to ER (GO:0045047)4.50147902
15cotranslational protein targeting to membrane (GO:0006613)4.50091136
16formation of translation preinitiation complex (GO:0001731)4.50001775
17translational initiation (GO:0006413)4.32106435
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28751122
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.28750712
20protein localization to endoplasmic reticulum (GO:0070972)4.25053359
21telomere maintenance via recombination (GO:0000722)4.23733404
22viral life cycle (GO:0019058)4.09683839
23cellular protein complex disassembly (GO:0043624)4.04735615
24folic acid-containing compound biosynthetic process (GO:0009396)3.96763160
25mitotic recombination (GO:0006312)3.91525562
26DNA replication checkpoint (GO:0000076)3.89617839
27ribosomal large subunit biogenesis (GO:0042273)3.80423210
28positive regulation of B cell differentiation (GO:0045579)3.78036033
29nucleobase biosynthetic process (GO:0046112)3.75458364
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.71171153
31ribonucleoprotein complex biogenesis (GO:0022613)3.68992811
32telomere maintenance via telomere lengthening (GO:0010833)3.67397276
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.67205816
34IMP biosynthetic process (GO:0006188)3.66899976
35protein complex disassembly (GO:0043241)3.65619779
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64937084
37positive regulation of gamma-delta T cell activation (GO:0046645)3.61581077
38deoxyribose phosphate biosynthetic process (GO:0046385)3.56669506
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.56669506
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54875866
41deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51337936
42purine nucleobase biosynthetic process (GO:0009113)3.45212236
43macromolecular complex disassembly (GO:0032984)3.44808610
44IMP metabolic process (GO:0046040)3.44423019
45translation (GO:0006412)3.41881747
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.38521408
47protein localization to kinetochore (GO:0034501)3.32750052
48purine nucleotide salvage (GO:0032261)3.31558138
49rRNA processing (GO:0006364)3.29640504
50ribosome biogenesis (GO:0042254)3.29426534
51pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26575371
52positive regulation of granulocyte differentiation (GO:0030854)3.24525538
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22685239
54mRNA catabolic process (GO:0006402)3.21655509
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19598884
56ATP synthesis coupled proton transport (GO:0015986)3.19598884
57negative T cell selection (GO:0043383)3.19256712
58rRNA metabolic process (GO:0016072)3.18837110
59oxidative phosphorylation (GO:0006119)3.16806316
60RNA catabolic process (GO:0006401)3.16723484
61CENP-A containing nucleosome assembly (GO:0034080)3.15032724
62mitotic nuclear envelope disassembly (GO:0007077)3.14917272
63chromatin remodeling at centromere (GO:0031055)3.14874388
64pseudouridine synthesis (GO:0001522)3.13975074
65mature B cell differentiation involved in immune response (GO:0002313)3.13779097
66Peyers patch development (GO:0048541)3.12424011
67mucosal-associated lymphoid tissue development (GO:0048537)3.12424011
68deoxyribose phosphate catabolic process (GO:0046386)3.10532767
69spliceosomal snRNP assembly (GO:0000387)3.09643557
70mitochondrial calcium ion transport (GO:0006851)3.08558954
71positive thymic T cell selection (GO:0045059)3.08484384
72negative thymic T cell selection (GO:0045060)3.07624546
73deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.06641572
74DNA replication-dependent nucleosome assembly (GO:0006335)3.06494442
75DNA replication-dependent nucleosome organization (GO:0034723)3.06494442
76regulation of mitochondrial translation (GO:0070129)3.05774486
77deoxyribonucleotide catabolic process (GO:0009264)3.05327462
78establishment of integrated proviral latency (GO:0075713)3.04793895
79ribosome assembly (GO:0042255)3.03790810
80DNA replication-independent nucleosome organization (GO:0034724)2.97216485
81DNA replication-independent nucleosome assembly (GO:0006336)2.97216485
82protein targeting to membrane (GO:0006612)2.96423856
83antigen processing and presentation of endogenous antigen (GO:0019883)2.96163991
84pteridine-containing compound biosynthetic process (GO:0042559)2.95316258
85folic acid metabolic process (GO:0046655)2.93387552
86regulation of B cell differentiation (GO:0045577)2.92670562
87negative regulation of RNA splicing (GO:0033119)2.92588367
88protein localization to chromosome, centromeric region (GO:0071459)2.92313001
89actin nucleation (GO:0045010)2.91040222
90purine deoxyribonucleotide catabolic process (GO:0009155)2.89961526
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87547997
92negative regulation of B cell apoptotic process (GO:0002903)2.86619090
93membrane disassembly (GO:0030397)2.85945593
94nuclear envelope disassembly (GO:0051081)2.85945593
95pyrimidine nucleotide catabolic process (GO:0006244)2.83314805
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83253063
97negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.81612815
98proteasome assembly (GO:0043248)2.81486462
99transcription-coupled nucleotide-excision repair (GO:0006283)2.81480621
100viral mRNA export from host cell nucleus (GO:0046784)2.80918129
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80684833
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80375157
103translesion synthesis (GO:0019985)2.80169719
1042-deoxyribonucleotide metabolic process (GO:0009394)2.79566870
105iron-sulfur cluster assembly (GO:0016226)2.79154853
106metallo-sulfur cluster assembly (GO:0031163)2.79154853
107positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78864825
108telomere organization (GO:0032200)2.78637880
109regulation of gamma-delta T cell differentiation (GO:0045586)2.77513825
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77144020
111telomere maintenance (GO:0000723)2.76909369
112regulation of B cell receptor signaling pathway (GO:0050855)2.76814526
113deoxyribose phosphate metabolic process (GO:0019692)2.76093584
114DNA duplex unwinding (GO:0032508)2.75252944
115cellular component biogenesis (GO:0044085)2.74408873
116nucleotide salvage (GO:0043173)2.73271244
117DNA geometric change (GO:0032392)2.72313866
118antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70421136
119cell cycle G1/S phase transition (GO:0044843)2.70086851
120G1/S transition of mitotic cell cycle (GO:0000082)2.70086851
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68935736
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68244776
123positive T cell selection (GO:0043368)2.67949651
124mitotic metaphase plate congression (GO:0007080)2.67787717
125ncRNA 3-end processing (GO:0043628)2.66084670
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65911942
127regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65144443
128pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.64962499
129regulation of protein heterodimerization activity (GO:0043497)2.64030765
130antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63742836
131base-excision repair (GO:0006284)2.62622938
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.62464031
133negative regulation of ligase activity (GO:0051352)2.62464031
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62110918
135thymic T cell selection (GO:0045061)2.61643553
136pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.58466459
137deoxyribonucleotide biosynthetic process (GO:0009263)2.58217221
138GDP-mannose metabolic process (GO:0019673)2.57958372
139B cell receptor signaling pathway (GO:0050853)2.56708334
140respiratory electron transport chain (GO:0022904)2.56579087
141immunoglobulin mediated immune response (GO:0016064)2.55454869
142autophagic vacuole fusion (GO:0000046)2.55447189
143pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.54896934
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54882715
145aerobic respiration (GO:0009060)2.54198932
146dosage compensation (GO:0007549)2.53839030
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52633329
148DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52515107
149mRNA splicing, via spliceosome (GO:0000398)2.52399575
150RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.52399575
151purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.52304197
152chromatin assembly or disassembly (GO:0006333)2.52279235
153postreplication repair (GO:0006301)2.51827103
154RNA splicing, via transesterification reactions (GO:0000375)2.51649044
155response to interferon-beta (GO:0035456)2.50754704
156intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50679374
157electron transport chain (GO:0022900)2.49860229
158T cell migration (GO:0072678)2.46604321
159T cell selection (GO:0045058)2.45219142
160mature B cell differentiation (GO:0002335)2.42983381
161signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42930620
162regulation of cellular amino acid metabolic process (GO:0006521)2.42902631
163mast cell activation (GO:0045576)2.42171164
164purine deoxyribonucleotide metabolic process (GO:0009151)2.41372462
165signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39788085
166signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39788085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45051378
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.16122398
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.04698026
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.15676796
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89554619
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.81252140
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74752150
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68248007
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.61482456
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59838592
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.58890130
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58255255
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.57283134
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56419719
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51268189
16XRN2_22483619_ChIP-Seq_HELA_Human2.28647010
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25501935
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22374524
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.19305269
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18202621
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17356583
22MYC_22102868_ChIP-Seq_BL_Human2.14803371
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13300455
24VDR_23849224_ChIP-Seq_CD4+_Human2.11291840
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10598643
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08947239
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.98934512
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90175459
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88089592
30FOXP3_21729870_ChIP-Seq_TREG_Human1.87840490
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87826411
32DCP1A_22483619_ChIP-Seq_HELA_Human1.85659494
33* GABP_19822575_ChIP-Seq_HepG2_Human1.82496923
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.73396444
35* VDR_21846776_ChIP-Seq_THP-1_Human1.72978173
36CIITA_25753668_ChIP-Seq_RAJI_Human1.70549622
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70193139
38* TTF2_22483619_ChIP-Seq_HELA_Human1.65666466
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65045903
40AR_21909140_ChIP-Seq_LNCAP_Human1.62782873
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62266148
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61908556
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59337377
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58139196
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55756727
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52923578
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52531493
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52275432
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50302932
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49857579
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44288102
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43708681
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43564941
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.40510434
55KDM5A_27292631_Chip-Seq_BREAST_Human1.37161166
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36271822
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.35856382
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35846322
59ELK1_19687146_ChIP-ChIP_HELA_Human1.33106329
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.32097221
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31054391
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30729578
63* SPI1_23547873_ChIP-Seq_NB4_Human1.29729475
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29117673
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27253508
66ZNF263_19887448_ChIP-Seq_K562_Human1.24897009
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24466850
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24313003
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23964402
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22024554
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20876966
72SCL_19346495_ChIP-Seq_HPC-7_Human1.20848774
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20803745
74TFEB_21752829_ChIP-Seq_HELA_Human1.20290517
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19479991
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18970881
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18036236
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17664613
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17049010
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16879826
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.15861323
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15049738
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14970027
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14294286
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14123474
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13843561
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13007536
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11481313
89* BCL6_27268052_Chip-Seq_Bcells_Human1.09375336
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05352473
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01900537
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01822661
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.01150038
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.00862971
95* MAF_26560356_Chip-Seq_TH1_Human1.00452551
96POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00275559
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00194677
98UTX_26944678_Chip-Seq_JUKART_Human0.99184879
99NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98328812
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97846549
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96530839
102RUNX1_22412390_ChIP-Seq_EML_Mouse0.95650729
103IRF8_22096565_ChIP-ChIP_GC-B_Human0.95082994
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93032570
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92981171
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92948383
107* MYB_26560356_Chip-Seq_TH2_Human0.92777901
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91487787
109* VDR_24763502_ChIP-Seq_THP-1_Human0.91436149
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90212668
111MAF_26560356_Chip-Seq_TH2_Human0.89710033
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87272245
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86968670
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86422916
115* MYB_26560356_Chip-Seq_TH1_Human0.86056771
116* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84709265
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84244224
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83929893
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83493515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58482292
2MP0010094_abnormal_chromosome_stability3.75943973
3MP0004957_abnormal_blastocyst_morpholog3.71508677
4MP0003111_abnormal_nucleus_morphology3.61738501
5MP0002396_abnormal_hematopoietic_system3.55020857
6MP0003077_abnormal_cell_cycle3.33519177
7MP0008057_abnormal_DNA_replication3.07220934
8MP0008058_abnormal_DNA_repair2.59193648
9MP0008007_abnormal_cellular_replicative2.56549598
10MP0000490_abnormal_crypts_of2.51703013
11MP0010352_gastrointestinal_tract_polyps2.28749752
12MP0005451_abnormal_body_composition2.26364361
13MP0003763_abnormal_thymus_physiology2.16977501
14MP0009333_abnormal_splenocyte_physiolog2.11275222
15MP0008932_abnormal_embryonic_tissue2.05276133
16MP0005397_hematopoietic_system_phenotyp1.99187741
17MP0001545_abnormal_hematopoietic_system1.99187741
18MP0001730_embryonic_growth_arrest1.91082477
19MP0001835_abnormal_antigen_presentation1.90908807
20MP0004808_abnormal_hematopoietic_stem1.90430564
21MP0000350_abnormal_cell_proliferation1.85931401
22MP0002398_abnormal_bone_marrow1.83592926
23MP0010307_abnormal_tumor_latency1.83493117
24MP0000685_abnormal_immune_system1.79849755
25MP0002019_abnormal_tumor_incidence1.69475842
26MP0003123_paternal_imprinting1.66177100
27MP0002722_abnormal_immune_system1.64843530
28MP0000689_abnormal_spleen_morphology1.60839841
29MP0006054_spinal_hemorrhage1.57474522
30MP0000703_abnormal_thymus_morphology1.53471002
31MP0000313_abnormal_cell_death1.52849134
32MP0003786_premature_aging1.48532875
33MP0002429_abnormal_blood_cell1.48228331
34MP0001853_heart_inflammation1.43760601
35MP0000716_abnormal_immune_system1.42962662
36MP0003806_abnormal_nucleotide_metabolis1.42669606
37MP0005671_abnormal_response_to1.38018246
38MP0002080_prenatal_lethality1.36594258
39MP0001800_abnormal_humoral_immune1.36153958
40MP0002420_abnormal_adaptive_immunity1.35042790
41MP0001697_abnormal_embryo_size1.33666034
42MP0001819_abnormal_immune_cell1.32796603
43MP0003186_abnormal_redox_activity1.30489832
44MP0002166_altered_tumor_susceptibility1.29835161
45MP0005058_abnormal_lysosome_morphology1.27782329
46MP0002009_preneoplasia1.27305517
47MP0000858_altered_metastatic_potential1.26000139
48MP0002452_abnormal_antigen_presenting1.25886007
49MP0009379_abnormal_foot_pigmentation1.24944181
50MP0004185_abnormal_adipocyte_glucose1.24912545
51MP0000465_gastrointestinal_hemorrhage1.23857362
52MP0009697_abnormal_copulation1.22577724
53MP0005025_abnormal_response_to1.22498083
54MP0005075_abnormal_melanosome_morpholog1.22230221
55MP0002723_abnormal_immune_serum1.21893281
56MP0002405_respiratory_system_inflammati1.18066574
57MP0009785_altered_susceptibility_to1.17979474
58MP0003436_decreased_susceptibility_to1.17065427
59MP0005380_embryogenesis_phenotype1.14907454
60MP0001672_abnormal_embryogenesis/_devel1.14907454
61MP0009840_abnormal_foam_cell1.14653775
62MP0003724_increased_susceptibility_to1.14614595
63MP0005464_abnormal_platelet_physiology1.14152810
64MP0010155_abnormal_intestine_physiology1.13105121
65MP0005000_abnormal_immune_tolerance1.13060599
66MP0005330_cardiomyopathy1.10958479
67MP0006035_abnormal_mitochondrial_morpho1.10371776
68MP0001873_stomach_inflammation1.09113540
69MP0003984_embryonic_growth_retardation1.08407673
70MP0005174_abnormal_tail_pigmentation1.08060057
71MP0000358_abnormal_cell_content/1.06121738
72MP0009278_abnormal_bone_marrow1.05754728
73MP0002088_abnormal_embryonic_growth/wei1.04654841
74MP0005645_abnormal_hypothalamus_physiol1.04336445
75MP0004947_skin_inflammation1.04153293
76MP0003567_abnormal_fetal_cardiomyocyte1.03884829
77MP0003656_abnormal_erythrocyte_physiolo1.03848571
78MP0003191_abnormal_cellular_cholesterol1.03061486
79MP0002086_abnormal_extraembryonic_tissu1.03046928
80MP0006036_abnormal_mitochondrial_physio1.01542625
81MP0002006_tumorigenesis1.01393130
82MP0003866_abnormal_defecation1.00219453
83MP0002132_abnormal_respiratory_system1.00091514
84MP0004197_abnormal_fetal_growth/weight/0.96458818
85MP0005023_abnormal_wound_healing0.96105766
86MP0002085_abnormal_embryonic_tissue0.95238694
87MP0009763_increased_sensitivity_to0.94017302
88MP0002095_abnormal_skin_pigmentation0.93813331
89MP0000477_abnormal_intestine_morphology0.92196126
90MP0004145_abnormal_muscle_electrophysio0.91936678
91MP0008260_abnormal_autophagy0.91933135
92MP0003303_peritoneal_inflammation0.90642298
93MP0003075_altered_response_to0.87687968
94MP0005165_increased_susceptibility_to0.87143925
95MP0000372_irregular_coat_pigmentation0.86458653
96MP0001845_abnormal_inflammatory_respons0.85717773
97MP0002419_abnormal_innate_immunity0.84987883
98MP0002148_abnormal_hypersensitivity_rea0.84445286
99MP0002084_abnormal_developmental_patter0.84030900
100MP0001533_abnormal_skeleton_physiology0.82958904
101MP0009764_decreased_sensitivity_to0.82500304
102MP0008995_early_reproductive_senescence0.81055768
103MP0001764_abnormal_homeostasis0.79515427
104MP0000749_muscle_degeneration0.78404751
105MP0005584_abnormal_enzyme/coenzyme_acti0.77636833
106MP0005266_abnormal_metabolism0.77442998
107MP0003221_abnormal_cardiomyocyte_apopto0.76224013
108MP0001790_abnormal_immune_system0.74989202
109MP0005387_immune_system_phenotype0.74989202
110MP0003646_muscle_fatigue0.73871478
111MP0005166_decreased_susceptibility_to0.73254042
112MP0008873_increased_physiological_sensi0.72765760
113MP0000598_abnormal_liver_morphology0.71395780
114MP0003300_gastrointestinal_ulcer0.71280956
115MP0004381_abnormal_hair_follicle0.70836445
116MP0006082_CNS_inflammation0.70093276
117MP0004036_abnormal_muscle_relaxation0.69320720
118MP0002877_abnormal_melanocyte_morpholog0.69082039
119MP0005384_cellular_phenotype0.69013276
120MP0005220_abnormal_exocrine_pancreas0.68866601
121MP0001293_anophthalmia0.68053255
122MP0005666_abnormal_adipose_tissue0.67498774
123MP0001851_eye_inflammation0.66736251
124MP0008469_abnormal_protein_level0.66011531
125MP0005319_abnormal_enzyme/_coenzyme0.65907496
126MP0008877_abnormal_DNA_methylation0.65396494
127MP0001881_abnormal_mammary_gland0.64537237
128MP0000371_diluted_coat_color0.63339813
129MP0005621_abnormal_cell_physiology0.63321582
130MP0001915_intracranial_hemorrhage0.63081331
131MP0004147_increased_porphyrin_level0.62887728
132MP0001145_abnormal_male_reproductive0.62843506
133MP0002210_abnormal_sex_determination0.62412262
134MP0003705_abnormal_hypodermis_morpholog0.62120549
135MP0003718_maternal_effect0.61756475
136MP0005076_abnormal_cell_differentiation0.59579225

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.14002525
2Abnormal number of erythroid precursors (HP:0012131)5.98030898
3Reticulocytopenia (HP:0001896)5.63859998
4Aplastic anemia (HP:0001915)4.25990706
5Thrombocytosis (HP:0001894)3.95250029
6Birth length less than 3rd percentile (HP:0003561)3.92157479
7Pallor (HP:0000980)3.81422343
8Macrocytic anemia (HP:0001972)3.75139183
9Agammaglobulinemia (HP:0004432)3.69048559
10Colon cancer (HP:0003003)3.59847402
11Increased intramyocellular lipid droplets (HP:0012240)3.59128481
12Severe combined immunodeficiency (HP:0004430)3.50983759
13Increased muscle lipid content (HP:0009058)3.38794978
14Rhabdomyolysis (HP:0003201)3.22959248
15Microretrognathia (HP:0000308)3.22046423
16Oral leukoplakia (HP:0002745)3.21604296
17IgM deficiency (HP:0002850)3.16873211
18Abnormal mitochondria in muscle tissue (HP:0008316)3.09520190
19Selective tooth agenesis (HP:0001592)3.07432321
20Autoimmune hemolytic anemia (HP:0001890)3.05166140
21Mitochondrial inheritance (HP:0001427)3.02876635
22Microvesicular hepatic steatosis (HP:0001414)2.98801844
23Multiple enchondromatosis (HP:0005701)2.96317850
24Combined immunodeficiency (HP:0005387)2.92555063
25Ragged-red muscle fibers (HP:0003200)2.88771110
26Obstructive lung disease (HP:0006536)2.88718240
27Chronic obstructive pulmonary disease (HP:0006510)2.88718240
28T lymphocytopenia (HP:0005403)2.86507752
29Acute necrotizing encephalopathy (HP:0006965)2.84390382
3011 pairs of ribs (HP:0000878)2.83573354
31Meningitis (HP:0001287)2.76832186
32Petechiae (HP:0000967)2.76385558
33Abnormality of the prostate (HP:0008775)2.76109205
34Exercise-induced myalgia (HP:0003738)2.71469599
35Increased CSF lactate (HP:0002490)2.70200894
36Recurrent fungal infections (HP:0002841)2.69243310
37Granulocytopenia (HP:0001913)2.68845559
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68767597
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68767597
40Breast hypoplasia (HP:0003187)2.68047188
41Abnormality of T cell physiology (HP:0011840)2.65607232
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.65180059
43Acute encephalopathy (HP:0006846)2.62874481
44Increased IgM level (HP:0003496)2.62476648
45Chronic otitis media (HP:0000389)2.61579778
46Gastrointestinal inflammation (HP:0004386)2.59886673
47Chromsome breakage (HP:0040012)2.59640183
48Type I transferrin isoform profile (HP:0003642)2.58268513
49Degeneration of anterior horn cells (HP:0002398)2.57326058
50Abnormality of the anterior horn cell (HP:0006802)2.57326058
51Nemaline bodies (HP:0003798)2.56586853
52Elevated erythrocyte sedimentation rate (HP:0003565)2.55966573
53Abnormality of T cell number (HP:0011839)2.54047273
54IgG deficiency (HP:0004315)2.50772713
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.50407355
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50309979
57Myelodysplasia (HP:0002863)2.49211867
58Rough bone trabeculation (HP:0100670)2.46489848
59Inflammation of the large intestine (HP:0002037)2.44768413
60Colitis (HP:0002583)2.43641936
61Trismus (HP:0000211)2.42607778
62Absent thumb (HP:0009777)2.42571592
63Abnormality of reticulocytes (HP:0004312)2.42138095
64Lactic acidosis (HP:0003128)2.40931701
65Encephalitis (HP:0002383)2.40505722
66Pancytopenia (HP:0001876)2.39535476
67Exercise intolerance (HP:0003546)2.37956043
68Stomatitis (HP:0010280)2.37591845
69Agnosia (HP:0010524)2.36891347
70Lymphoma (HP:0002665)2.33859229
71Cerebral palsy (HP:0100021)2.33746458
72Muscle fiber inclusion bodies (HP:0100299)2.33415650
73Chronic mucocutaneous candidiasis (HP:0002728)2.32483194
74Recurrent cutaneous fungal infections (HP:0011370)2.32483194
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.31820222
76Myoglobinuria (HP:0002913)2.31334712
77Reduced antithrombin III activity (HP:0001976)2.31159608
78Abnormality of chromosome stability (HP:0003220)2.30002191
79Increased hepatocellular lipid droplets (HP:0006565)2.28908715
80Basal cell carcinoma (HP:0002671)2.28009394
81Abnormality of T cells (HP:0002843)2.27769126
82Dicarboxylic aciduria (HP:0003215)2.27554927
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27554927
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27140078
85Bone marrow hypocellularity (HP:0005528)2.26751734
86Hepatosplenomegaly (HP:0001433)2.26628363
873-Methylglutaconic aciduria (HP:0003535)2.25526759
88Mediastinal lymphadenopathy (HP:0100721)2.25205858
89Progressive macrocephaly (HP:0004481)2.24446441
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23764261
91Acute hepatic failure (HP:0006554)2.22596921
92Abnormality of the preputium (HP:0100587)2.22102390
93Recurrent abscess formation (HP:0002722)2.21131510
94Progressive muscle weakness (HP:0003323)2.20991551
95Ependymoma (HP:0002888)2.20114057
96Premature graying of hair (HP:0002216)2.19991859
97Lipid accumulation in hepatocytes (HP:0006561)2.19575516
98Poikiloderma (HP:0001029)2.19513998
99Slender long bone (HP:0003100)2.18923819
100Renal Fanconi syndrome (HP:0001994)2.18377152
101Muscle stiffness (HP:0003552)2.18237485
102Neoplasm of the pancreas (HP:0002894)2.18085211
103Poor head control (HP:0002421)2.17804483
104Meckel diverticulum (HP:0002245)2.15076715
105Medulloblastoma (HP:0002885)2.13523432
106Abnormal protein glycosylation (HP:0012346)2.12118209
107Abnormal glycosylation (HP:0012345)2.12118209
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12118209
109Abnormal protein N-linked glycosylation (HP:0012347)2.12118209
110Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10274123
111Cellulitis (HP:0100658)2.09618983
112Abnormality of the ileum (HP:0001549)2.08909468
113Cerebral edema (HP:0002181)2.08546648
114Prostate neoplasm (HP:0100787)2.08199758
115Fatigue (HP:0012378)2.07919808
116Eczematoid dermatitis (HP:0000976)2.04778239
117Cerebral hypomyelination (HP:0006808)2.03937874
118Abnormality of fatty-acid metabolism (HP:0004359)2.01659870
119Testicular atrophy (HP:0000029)2.01550510
120Neck muscle weakness (HP:0000467)2.00655748
121Hypertensive crisis (HP:0100735)2.00480704
122Increased IgE level (HP:0003212)2.00434147
123Hypergammaglobulinemia (HP:0010702)2.00155068
124Rhabdomyosarcoma (HP:0002859)1.99187217
125Recurrent viral infections (HP:0004429)1.99022698
126Epistaxis (HP:0000421)1.98884849
127Panhypogammaglobulinemia (HP:0003139)1.98139201
128Amaurosis fugax (HP:0100576)1.94472127
129Patellar aplasia (HP:0006443)1.93986866
130Recurrent bronchitis (HP:0002837)1.93258303
131B lymphocytopenia (HP:0010976)1.90833000
132Abnormality of B cell number (HP:0010975)1.90833000
133Increased serum lactate (HP:0002151)1.89479085
134Prominent nose (HP:0000448)1.89151747
135Hepatic necrosis (HP:0002605)1.88523524
136Hepatocellular necrosis (HP:0001404)1.87380478
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.87220734
138Carpal bone hypoplasia (HP:0001498)1.86346942
139Acute lymphatic leukemia (HP:0006721)1.85902969
140Cellular immunodeficiency (HP:0005374)1.83928922
141Impaired platelet aggregation (HP:0003540)1.79589052
142Abnormal platelet function (HP:0011869)1.79589052
143Calcaneovalgus deformity (HP:0001848)1.79128231
144Squamous cell carcinoma (HP:0002860)1.78758911
145Muscle fiber atrophy (HP:0100295)1.77649220
146Abnormal delayed hypersensitivity skin test (HP:0002963)1.77623087
147Aplasia/Hypoplasia of the thymus (HP:0010515)1.77244206
148Aplasia/Hypoplasia of the patella (HP:0006498)1.77140244
149High pitched voice (HP:0001620)1.77023889
150Abnormality of the calcaneus (HP:0008364)1.73949377
151Abnormality of DNA repair (HP:0003254)1.73029310
152Increased serum ferritin (HP:0003281)1.72974321
153Pulmonary fibrosis (HP:0002206)1.71478156
154Tracheoesophageal fistula (HP:0002575)1.70110323
155Megaloblastic anemia (HP:0001889)1.69606292
156Abnormality of cells of the lymphoid lineage (HP:0012140)1.69018519
157Myositis (HP:0100614)1.64920802
158Prolonged bleeding time (HP:0003010)1.64164770
159Abnormal number of incisors (HP:0011064)1.64052753
160Leukopenia (HP:0001882)1.63695480
161Small intestinal stenosis (HP:0012848)1.63478564
162Duodenal stenosis (HP:0100867)1.63478564
163Missing ribs (HP:0000921)1.61655382
164Sloping forehead (HP:0000340)1.61534305
165Abnormal trabecular bone morphology (HP:0100671)1.60917828
166Neoplasm of the colon (HP:0100273)1.60877548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.42022232
2WEE13.41996614
3NME23.38058226
4CDC73.37877839
5BUB13.11934436
6EIF2AK12.61054563
7EEF2K2.58991709
8MAP4K12.27199363
9NEK22.26299301
10STK162.22826685
11TESK22.21246169
12FLT32.05301429
13PASK2.04342438
14ACVR1B2.04326458
15BRSK22.01720029
16TXK2.01149432
17RPS6KB21.95842992
18MAP3K101.89637239
19EIF2AK31.86413235
20PKN21.85372350
21RPS6KA41.78104921
22DYRK31.75557824
23PIM21.71098756
24FES1.69781481
25TAOK31.67886522
26VRK11.62403018
27KDR1.59295540
28MAP3K121.57958355
29TLK11.54913222
30PRPF4B1.49336545
31CDK71.48007096
32SRPK11.47706933
33LRRK21.43891735
34RIPK41.42736932
35PAK41.37460459
36KIT1.36524323
37MAP2K31.35867936
38ATR1.35784370
39PLK11.34275813
40TGFBR11.34201584
41BTK1.33640396
42AURKB1.29334140
43NEK11.29289114
44BCKDK1.28940721
45TTK1.28526016
46MAP3K81.25713427
47CDK41.24768709
48IKBKE1.24628996
49TRIB31.24364254
50STK101.20583936
51MAPKAPK31.20557877
52ZAP701.20534337
53TSSK61.16022046
54PLK41.14289966
55DAPK11.11550527
56PIK3CG1.08161349
57MAP3K111.08100492
58TESK11.07513931
59SMG11.07458755
60ERN11.07405744
61BRSK11.06505340
62PIM11.05646305
63TEC1.02426677
64TNK21.00893049
65BMPR20.99787727
66CSF1R0.98753503
67AURKA0.98563445
68BLK0.98149597
69TYK20.97492626
70MAP3K140.97005285
71MAP3K130.92476214
72ARAF0.92010528
73OBSCN0.91890928
74GRK60.91200862
75ILK0.88834844
76NUAK10.87899044
77CHEK20.87806889
78IRAK30.85506615
79JAK30.85392497
80STK40.80845439
81CDK190.79261604
82MKNK10.78631035
83PBK0.75417823
84CHEK10.73215714
85MAPKAPK50.72186835
86TBK10.71624981
87MST40.69326237
88CCNB10.66070482
89PAK10.63106983
90IRAK40.60629526
91CSNK2A20.56761506
92HCK0.56683482
93CDK80.56127314
94ZAK0.55326763
95CDK120.54904279
96PRKCQ0.54652819
97RAF10.54575084
98SYK0.53432422
99MAP3K10.52781288
100CDK20.52544749
101CSNK2A10.51932277
102LIMK10.50500711
103IKBKB0.47845591
104MUSK0.46843644
105ATM0.46730339
106MAP4K20.46269530
107TRPM70.45170164
108MAPK110.43790442
109RPS6KA50.43208536
110MAP2K20.42628096
111LYN0.42429565
112EIF2AK20.42401762
113MAPK120.41510684
114BRAF0.40715706
115CLK10.40675862
116CSNK1G30.38917378
117NLK0.37606984
118PLK30.37528381
119MYLK0.37459367
120LCK0.36469569
121MAPKAPK20.36195228
122AKT20.35856632
123MATK0.35854826
124EPHA20.35817926
125MAP3K50.35339965
126ABL20.35082631
127MAP2K60.34364622
128TAOK20.33762122
129DAPK30.33580054
130CDK60.33268135
131ALK0.32796794
132MAP3K30.32641607
133PAK20.31632993
134ITK0.30208533
135RPS6KA60.29958103

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.35259547
2Ribosome_Homo sapiens_hsa030104.47554966
3Mismatch repair_Homo sapiens_hsa034304.06968687
4Base excision repair_Homo sapiens_hsa034103.16288699
5Proteasome_Homo sapiens_hsa030503.01406218
6Spliceosome_Homo sapiens_hsa030402.91290781
7Homologous recombination_Homo sapiens_hsa034402.82535133
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77401256
9RNA polymerase_Homo sapiens_hsa030202.68729600
10Nucleotide excision repair_Homo sapiens_hsa034202.66951608
11Pyrimidine metabolism_Homo sapiens_hsa002402.51144712
12One carbon pool by folate_Homo sapiens_hsa006702.43562329
13RNA transport_Homo sapiens_hsa030132.42195233
14Oxidative phosphorylation_Homo sapiens_hsa001902.37114638
15Allograft rejection_Homo sapiens_hsa053302.29086740
16Cell cycle_Homo sapiens_hsa041102.14283218
17Autoimmune thyroid disease_Homo sapiens_hsa053202.13092252
18Asthma_Homo sapiens_hsa053102.11450287
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07871358
20Graft-versus-host disease_Homo sapiens_hsa053322.03264020
21Non-homologous end-joining_Homo sapiens_hsa034501.89329081
22Fanconi anemia pathway_Homo sapiens_hsa034601.69734461
23Type I diabetes mellitus_Homo sapiens_hsa049401.64513038
24RNA degradation_Homo sapiens_hsa030181.61241070
25p53 signaling pathway_Homo sapiens_hsa041151.46142259
26Alzheimers disease_Homo sapiens_hsa050101.36874772
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35760302
28Sulfur relay system_Homo sapiens_hsa041221.34428887
29Folate biosynthesis_Homo sapiens_hsa007901.30158812
30Fatty acid elongation_Homo sapiens_hsa000621.29674092
31Antigen processing and presentation_Homo sapiens_hsa046121.26251850
32Basal transcription factors_Homo sapiens_hsa030221.22624751
33Protein export_Homo sapiens_hsa030601.22208414
34Systemic lupus erythematosus_Homo sapiens_hsa053221.19409360
35Primary immunodeficiency_Homo sapiens_hsa053401.18888203
36Purine metabolism_Homo sapiens_hsa002301.17878539
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14647725
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.11339682
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09779602
40Pentose phosphate pathway_Homo sapiens_hsa000301.08862628
41Herpes simplex infection_Homo sapiens_hsa051681.08438364
42T cell receptor signaling pathway_Homo sapiens_hsa046601.06313458
43mRNA surveillance pathway_Homo sapiens_hsa030151.05208177
44Epstein-Barr virus infection_Homo sapiens_hsa051691.02802748
45N-Glycan biosynthesis_Homo sapiens_hsa005100.98797616
46Viral carcinogenesis_Homo sapiens_hsa052030.92020704
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90272920
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88876441
49Biosynthesis of amino acids_Homo sapiens_hsa012300.83774259
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.83235197
51Legionellosis_Homo sapiens_hsa051340.82091349
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.79406228
53Thyroid cancer_Homo sapiens_hsa052160.79264265
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78759621
55Selenocompound metabolism_Homo sapiens_hsa004500.74457833
56Shigellosis_Homo sapiens_hsa051310.71147443
57HTLV-I infection_Homo sapiens_hsa051660.69873060
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69586506
59Cardiac muscle contraction_Homo sapiens_hsa042600.69176368
60Peroxisome_Homo sapiens_hsa041460.68834944
61Apoptosis_Homo sapiens_hsa042100.68674241
62Rheumatoid arthritis_Homo sapiens_hsa053230.68468704
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68151209
64Pyruvate metabolism_Homo sapiens_hsa006200.65453757
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62321458
66Measles_Homo sapiens_hsa051620.61830583
67Glutathione metabolism_Homo sapiens_hsa004800.61096588
68Acute myeloid leukemia_Homo sapiens_hsa052210.60273547
69Tuberculosis_Homo sapiens_hsa051520.59593386
70Staphylococcus aureus infection_Homo sapiens_hsa051500.59123029
71Carbon metabolism_Homo sapiens_hsa012000.57658493
72Other glycan degradation_Homo sapiens_hsa005110.57286478
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56147897
74Small cell lung cancer_Homo sapiens_hsa052220.53167552
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51768147
76Galactose metabolism_Homo sapiens_hsa000520.51226774
77Osteoclast differentiation_Homo sapiens_hsa043800.49922422
78Hepatitis B_Homo sapiens_hsa051610.49466930
79Parkinsons disease_Homo sapiens_hsa050120.48780968
80Leishmaniasis_Homo sapiens_hsa051400.48484519
81Hematopoietic cell lineage_Homo sapiens_hsa046400.47860798
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.47822443
83Chronic myeloid leukemia_Homo sapiens_hsa052200.46596133
84B cell receptor signaling pathway_Homo sapiens_hsa046620.46097370
85Platelet activation_Homo sapiens_hsa046110.45904922
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45688802
87Regulation of autophagy_Homo sapiens_hsa041400.45486615
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44284206
89Huntingtons disease_Homo sapiens_hsa050160.43276835
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41517448
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41360178
92Bladder cancer_Homo sapiens_hsa052190.41088117
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.38890105
94Renin-angiotensin system_Homo sapiens_hsa046140.37934237
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37601976
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37248997
97Influenza A_Homo sapiens_hsa051640.34790355
98Salmonella infection_Homo sapiens_hsa051320.34497674
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33769279
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32722610
101Alcoholism_Homo sapiens_hsa050340.31949456
102Viral myocarditis_Homo sapiens_hsa054160.31086440
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31012440
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30877033
105Oocyte meiosis_Homo sapiens_hsa041140.30633295
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.30495207
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29730906
108Colorectal cancer_Homo sapiens_hsa052100.29465551
109Pancreatic cancer_Homo sapiens_hsa052120.28008785
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27837710
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.27766336
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27108942
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26344118
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25647922
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.24750191
116Metabolic pathways_Homo sapiens_hsa011000.24039861
117MicroRNAs in cancer_Homo sapiens_hsa052060.23763968
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23566774
119Notch signaling pathway_Homo sapiens_hsa043300.22434223
120Fructose and mannose metabolism_Homo sapiens_hsa000510.21802608
121Non-small cell lung cancer_Homo sapiens_hsa052230.21702140
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21659981
123Toxoplasmosis_Homo sapiens_hsa051450.21510533
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18181621
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17357639

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