GTF3C2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.51248900
2DNA unwinding involved in DNA replication (GO:0006268)4.97907464
3nuclear pore complex assembly (GO:0051292)4.77921221
4mitotic sister chromatid cohesion (GO:0007064)4.67228393
5nuclear pore organization (GO:0006999)4.65499482
6protein localization to chromosome, centromeric region (GO:0071459)4.55174148
7ribosome assembly (GO:0042255)4.30565370
8regulation of RNA export from nucleus (GO:0046831)4.18628243
9peptidyl-arginine omega-N-methylation (GO:0035247)4.14635626
10mitotic chromosome condensation (GO:0007076)4.14570979
11histone arginine methylation (GO:0034969)4.03957073
12DNA replication initiation (GO:0006270)4.01965453
13DNA strand elongation involved in DNA replication (GO:0006271)3.93220485
14pre-miRNA processing (GO:0031054)3.87388465
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.84511326
16mitotic nuclear envelope disassembly (GO:0007077)3.84387513
17regulation of sister chromatid cohesion (GO:0007063)3.81211726
18heterochromatin organization (GO:0070828)3.79749375
19DNA strand elongation (GO:0022616)3.78451120
20regulation of spindle organization (GO:0090224)3.70028824
21negative regulation of histone methylation (GO:0031061)3.68917777
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67218121
23peptidyl-arginine methylation (GO:0018216)3.64990535
24peptidyl-arginine N-methylation (GO:0035246)3.64990535
25positive regulation of chromosome segregation (GO:0051984)3.64241012
26mitotic metaphase plate congression (GO:0007080)3.62190978
27regulation of translational fidelity (GO:0006450)3.61850045
28pore complex assembly (GO:0046931)3.61331635
29negative regulation of RNA splicing (GO:0033119)3.58077508
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57857157
31spliceosomal tri-snRNP complex assembly (GO:0000244)3.57198904
32DNA replication-independent nucleosome organization (GO:0034724)3.53245515
33DNA replication-independent nucleosome assembly (GO:0006336)3.53245515
34nuclear envelope disassembly (GO:0051081)3.53061729
35membrane disassembly (GO:0030397)3.53061729
36protein complex localization (GO:0031503)3.52508111
37CENP-A containing nucleosome assembly (GO:0034080)3.52080020
38DNA duplex unwinding (GO:0032508)3.50821551
39negative regulation of mRNA processing (GO:0050686)3.49440656
40DNA geometric change (GO:0032392)3.49235001
41L-serine metabolic process (GO:0006563)3.48682825
42proline biosynthetic process (GO:0006561)3.48624990
43regulation of histone H3-K27 methylation (GO:0061085)3.47411939
44formation of translation preinitiation complex (GO:0001731)3.45944733
45protein localization to chromosome (GO:0034502)3.45480019
46establishment of integrated proviral latency (GO:0075713)3.44128324
47chromatin remodeling at centromere (GO:0031055)3.40098062
48transcription from mitochondrial promoter (GO:0006390)3.39164264
49DNA replication checkpoint (GO:0000076)3.38059811
50DNA topological change (GO:0006265)3.35724385
51DNA strand renaturation (GO:0000733)3.35482271
52telomere maintenance via semi-conservative replication (GO:0032201)3.34112416
53protein-DNA complex disassembly (GO:0032986)3.32429853
54nucleosome disassembly (GO:0006337)3.32429853
55sister chromatid segregation (GO:0000819)3.31246016
56regulation of histone H3-K9 methylation (GO:0051570)3.31231300
57mitotic recombination (GO:0006312)3.31143923
58mitotic sister chromatid segregation (GO:0000070)3.26887153
59metaphase plate congression (GO:0051310)3.25448402
60nucleobase biosynthetic process (GO:0046112)3.24992239
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23636998
62regulation of mitotic spindle organization (GO:0060236)3.23597257
63regulation of nucleobase-containing compound transport (GO:0032239)3.22992298
64DNA replication-dependent nucleosome assembly (GO:0006335)3.21463247
65DNA replication-dependent nucleosome organization (GO:0034723)3.21463247
66folic acid-containing compound biosynthetic process (GO:0009396)3.20344760
67telomere maintenance via recombination (GO:0000722)3.20204873
68kinetochore organization (GO:0051383)3.17992285
69ATP-dependent chromatin remodeling (GO:0043044)3.17859932
70maturation of SSU-rRNA (GO:0030490)3.13397864
71DNA packaging (GO:0006323)3.12882944
72positive regulation of histone H3-K4 methylation (GO:0051571)3.10746462
73mitochondrial RNA metabolic process (GO:0000959)3.06449677
74negative regulation of mRNA metabolic process (GO:1903312)3.06340427
75chromatin assembly or disassembly (GO:0006333)3.03949677
76ribosome biogenesis (GO:0042254)3.02401591
77DNA conformation change (GO:0071103)3.01954718
78spindle checkpoint (GO:0031577)2.99349267
79histone exchange (GO:0043486)2.99110919
80tRNA aminoacylation for protein translation (GO:0006418)2.97086949
81nucleotide-excision repair, DNA gap filling (GO:0006297)2.94580310
82nuclear envelope organization (GO:0006998)2.93069343
83regulation of chromosome segregation (GO:0051983)2.92676383
84non-recombinational repair (GO:0000726)2.91927529
85double-strand break repair via nonhomologous end joining (GO:0006303)2.91927529
86RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.91773790
87mRNA splicing, via spliceosome (GO:0000398)2.91773790
88positive regulation of histone methylation (GO:0031062)2.90886358
89telomere maintenance via telomere lengthening (GO:0010833)2.90770828
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.90512115
91somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90512115
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.90024923
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.90024923
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.90024923
95mitotic spindle checkpoint (GO:0071174)2.89934894
96COPI coating of Golgi vesicle (GO:0048205)2.89845531
97Golgi transport vesicle coating (GO:0048200)2.89845531
98RNA splicing, via transesterification reactions (GO:0000375)2.88924207
99IMP metabolic process (GO:0046040)2.88518961
100chromatin assembly (GO:0031497)2.87408611
101meiotic chromosome segregation (GO:0045132)2.86066556
102tRNA aminoacylation (GO:0043039)2.85697468
103amino acid activation (GO:0043038)2.85697468
104base-excision repair (GO:0006284)2.85483075
105mitochondrial DNA metabolic process (GO:0032042)2.84095497
106NADPH regeneration (GO:0006740)2.83752096
107regulation of histone methylation (GO:0031060)2.83724926
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.83135357
109histone H3-K9 methylation (GO:0051567)2.83105733
110attachment of spindle microtubules to kinetochore (GO:0008608)2.82619886
111viral mRNA export from host cell nucleus (GO:0046784)2.82470504
112cellular protein complex localization (GO:0034629)2.80265599
113chromatin silencing (GO:0006342)2.79866259
114mismatch repair (GO:0006298)2.79847655
115rRNA modification (GO:0000154)2.79662306
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79195833
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79195833
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79195833
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.79195833
120negative regulation of sister chromatid segregation (GO:0033046)2.79195833
121rRNA methylation (GO:0031167)2.78291881
122regulation of gene silencing by RNA (GO:0060966)2.77874831
123regulation of posttranscriptional gene silencing (GO:0060147)2.77874831
124regulation of gene silencing by miRNA (GO:0060964)2.77874831
125negative regulation of gene expression, epigenetic (GO:0045814)2.76003788
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.74642154
127chromosome segregation (GO:0007059)2.73700511
128regulation of histone H3-K4 methylation (GO:0051569)2.73690539
129alternative mRNA splicing, via spliceosome (GO:0000380)2.73358411
130purine nucleobase biosynthetic process (GO:0009113)2.73025289
131IMP biosynthetic process (GO:0006188)2.72760274
132intra-S DNA damage checkpoint (GO:0031573)2.72598983
133chromosome condensation (GO:0030261)2.71969895
134dosage compensation (GO:0007549)2.70652681
135negative regulation of chromosome segregation (GO:0051985)2.69250781
136RNA export from nucleus (GO:0006405)2.69066489
137mitotic G1 DNA damage checkpoint (GO:0031571)2.66222042
138establishment of chromosome localization (GO:0051303)2.64877483
139glucocorticoid receptor signaling pathway (GO:0042921)2.64563871
140RNA stabilization (GO:0043489)2.64400084
141mRNA stabilization (GO:0048255)2.64400084
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64031920
143termination of RNA polymerase II transcription (GO:0006369)2.63998362
144mRNA transport (GO:0051028)2.63076812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.40246184
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21690872
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.57639175
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41168979
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05616228
6AR_21909140_ChIP-Seq_LNCAP_Human2.87962047
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73754408
8MYC_22102868_ChIP-Seq_BL_Human2.66320970
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47240873
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37646771
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.34291866
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.34009029
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30185521
14CIITA_25753668_ChIP-Seq_RAJI_Human2.19562584
15XRN2_22483619_ChIP-Seq_HELA_Human2.11124818
16E2F7_22180533_ChIP-Seq_HELA_Human10.7164191
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99653122
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98288027
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93093932
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90429499
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.81989966
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81504893
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71076216
24VDR_21846776_ChIP-Seq_THP-1_Human1.65615778
25KDM5A_27292631_Chip-Seq_BREAST_Human1.64468737
26* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58434342
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57482663
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54679652
29* ETS1_20019798_ChIP-Seq_JURKAT_Human1.54130010
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.53513668
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53051477
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.52795940
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.51249667
34* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49446139
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47207201
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46922583
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.45902711
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45205627
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43350740
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41797523
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41102135
42TTF2_22483619_ChIP-Seq_HELA_Human1.40474247
43VDR_23849224_ChIP-Seq_CD4+_Human1.37497397
44SCL_19346495_ChIP-Seq_HPC-7_Human1.35585961
45* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34119013
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33746691
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31895178
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31655780
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30707561
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29928069
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27797345
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22813821
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22803093
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22333304
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21916465
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21795893
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21456149
58DCP1A_22483619_ChIP-Seq_HELA_Human1.20945299
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19492066
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18249657
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18161794
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18051538
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17877796
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17800927
65TCF7_22412390_ChIP-Seq_EML_Mouse1.17133164
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15542241
67* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14793330
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.14272172
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12826331
70* GABP_19822575_ChIP-Seq_HepG2_Human1.12777056
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.12608321
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12569837
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08098135
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06915278
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06915278
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06915278
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06550846
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06352217
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05751589
80CHD1_26751641_Chip-Seq_LNCaP_Human1.05689766
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04172119
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.03706984
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02289008
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01797004
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01743402
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01144275
87* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99673676
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99037247
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99000675
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98525576
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97948123
92ELK1_19687146_ChIP-ChIP_HELA_Human0.97639347
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96951411
94* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96075984
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95959418
96* UTX_26944678_Chip-Seq_JUKART_Human0.95941206
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95319551
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95116566
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94190806
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94035197
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93790483
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93546946
103MYC_18940864_ChIP-ChIP_HL60_Human0.92810705
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92796234
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92157388
106MYB_26560356_Chip-Seq_TH1_Human0.91625039
107TFEB_21752829_ChIP-Seq_HELA_Human0.90320017
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90160747
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.89457263
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89407256
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88297489
112MAF_26560356_Chip-Seq_TH1_Human0.87616544
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87244267
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87040010
115* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86239714
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85478637
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83265426
118KDM2B_26808549_Chip-Seq_DND41_Human0.83051563
119* NCOR1_26117541_ChIP-Seq_K562_Human0.81688984
120EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81322278
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81261844
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81056047
123ZNF263_19887448_ChIP-Seq_K562_Human0.81020572
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80554855
125* FOXP1_21924763_ChIP-Seq_HESCs_Human0.79761133
126* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76879558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.89953692
2MP0010094_abnormal_chromosome_stability3.76683919
3MP0003111_abnormal_nucleus_morphology3.46315238
4MP0003693_abnormal_embryo_hatching3.28303621
5MP0003077_abnormal_cell_cycle3.27797915
6MP0004957_abnormal_blastocyst_morpholog2.94812658
7MP0002396_abnormal_hematopoietic_system2.59850435
8MP0008007_abnormal_cellular_replicative2.29933828
9MP0008058_abnormal_DNA_repair2.24481582
10MP0010352_gastrointestinal_tract_polyps2.23648230
11MP0001730_embryonic_growth_arrest2.22991034
12MP0000350_abnormal_cell_proliferation1.97203628
13MP0003567_abnormal_fetal_cardiomyocyte1.90508916
14MP0001672_abnormal_embryogenesis/_devel1.88006379
15MP0005380_embryogenesis_phenotype1.88006379
16MP0010030_abnormal_orbit_morphology1.84625176
17MP0003123_paternal_imprinting1.83879332
18MP0009697_abnormal_copulation1.82660194
19MP0004197_abnormal_fetal_growth/weight/1.81675031
20MP0008932_abnormal_embryonic_tissue1.81198982
21MP0004233_abnormal_muscle_weight1.78634725
22MP0001697_abnormal_embryo_size1.78558166
23MP0002085_abnormal_embryonic_tissue1.77200957
24MP0002084_abnormal_developmental_patter1.73500959
25MP0005451_abnormal_body_composition1.73492659
26MP0004808_abnormal_hematopoietic_stem1.70388456
27MP0003984_embryonic_growth_retardation1.66764306
28MP0002088_abnormal_embryonic_growth/wei1.66428759
29MP0005076_abnormal_cell_differentiation1.66071995
30MP0008877_abnormal_DNA_methylation1.57467422
31MP0000537_abnormal_urethra_morphology1.55222743
32MP0002080_prenatal_lethality1.51800839
33MP0002086_abnormal_extraembryonic_tissu1.48997166
34MP0009053_abnormal_anal_canal1.47822238
35MP0005501_abnormal_skin_physiology1.43463625
36MP0003121_genomic_imprinting1.42422373
37MP0002254_reproductive_system_inflammat1.42225731
38MP0001293_anophthalmia1.39930694
39MP0008260_abnormal_autophagy1.39623225
40MP0003937_abnormal_limbs/digits/tail_de1.39471815
41MP0003941_abnormal_skin_development1.37587147
42MP0009672_abnormal_birth_weight1.36573078
43MP0006035_abnormal_mitochondrial_morpho1.36511727
44MP0002249_abnormal_larynx_morphology1.29301047
45MP0000383_abnormal_hair_follicle1.28943111
46MP0009278_abnormal_bone_marrow1.28759718
47MP0000490_abnormal_crypts_of1.26734331
48MP0009703_decreased_birth_body1.25680501
49MP0002796_impaired_skin_barrier1.24475534
50MP0003763_abnormal_thymus_physiology1.23551146
51MP0000703_abnormal_thymus_morphology1.20665266
52MP0005394_taste/olfaction_phenotype1.15191702
53MP0005499_abnormal_olfactory_system1.15191702
54MP0000313_abnormal_cell_death1.13999507
55MP0003566_abnormal_cell_adhesion1.13018887
56MP0002938_white_spotting1.12691908
57MP0001346_abnormal_lacrimal_gland1.12520742
58MP0001915_intracranial_hemorrhage1.11928999
59MP0010678_abnormal_skin_adnexa1.11588299
60MP0003786_premature_aging1.11345260
61MP0003119_abnormal_digestive_system1.11086619
62MP0000358_abnormal_cell_content/1.11045792
63MP0003935_abnormal_craniofacial_develop1.10197889
64MP0002009_preneoplasia1.09128312
65MP0003115_abnormal_respiratory_system1.08877124
66MP0002092_abnormal_eye_morphology1.08856596
67MP0000733_abnormal_muscle_development1.07006868
68MP0000428_abnormal_craniofacial_morphol1.06121471
69MP0008995_early_reproductive_senescence1.05898496
70MP0010307_abnormal_tumor_latency1.04930724
71MP0003890_abnormal_embryonic-extraembry1.04372023
72MP0002111_abnormal_tail_morphology1.04119769
73MP0002019_abnormal_tumor_incidence1.03768506
74MP0002653_abnormal_ependyma_morphology1.03410398
75MP0008789_abnormal_olfactory_epithelium1.03361914
76MP0002697_abnormal_eye_size1.02179650
77MP0005397_hematopoietic_system_phenotyp0.99171143
78MP0001545_abnormal_hematopoietic_system0.99171143
79MP0002925_abnormal_cardiovascular_devel0.97716615
80MP0004185_abnormal_adipocyte_glucose0.97616545
81MP0000432_abnormal_head_morphology0.97586195
82MP0005395_other_phenotype0.94886368
83MP0002132_abnormal_respiratory_system0.94104532
84MP0002210_abnormal_sex_determination0.91834192
85MP0001286_abnormal_eye_development0.89276887
86MP0001849_ear_inflammation0.88496939
87MP0002398_abnormal_bone_marrow0.88342861
88MP0000678_abnormal_parathyroid_gland0.88122751
89MP0003315_abnormal_perineum_morphology0.87538122
90MP0001145_abnormal_male_reproductive0.87198269
91MP0002089_abnormal_postnatal_growth/wei0.86656373
92MP0005384_cellular_phenotype0.85581549
93MP0000566_synostosis0.84852715
94MP0006292_abnormal_olfactory_placode0.84504344
95MP0002722_abnormal_immune_system0.83220433
96MP0003705_abnormal_hypodermis_morpholog0.83094030
97MP0010234_abnormal_vibrissa_follicle0.82655240
98MP0003942_abnormal_urinary_system0.81802128
99MP0000647_abnormal_sebaceous_gland0.80824607
100MP0003943_abnormal_hepatobiliary_system0.80804676
101MP0003861_abnormal_nervous_system0.80771912
102MP0003699_abnormal_female_reproductive0.80713599
103MP0005621_abnormal_cell_physiology0.80425734
104MP0003718_maternal_effect0.80167869
105MP0000689_abnormal_spleen_morphology0.80091033
106MP0004264_abnormal_extraembryonic_tissu0.80089936
107MP0001661_extended_life_span0.79751824
108MP0001873_stomach_inflammation0.79419061
109MP0009333_abnormal_splenocyte_physiolog0.79216623
110MP0002932_abnormal_joint_morphology0.78204811
111MP0002166_altered_tumor_susceptibility0.77992409
112MP0003938_abnormal_ear_development0.76954917
113MP0004782_abnormal_surfactant_physiolog0.76889253
114MP0000653_abnormal_sex_gland0.76476257
115MP0002163_abnormal_gland_morphology0.75728194
116MP0006054_spinal_hemorrhage0.75489070
117MP0003755_abnormal_palate_morphology0.72996920
118MP0002282_abnormal_trachea_morphology0.72581303
119MP0002098_abnormal_vibrissa_morphology0.70888278
120MP0001784_abnormal_fluid_regulation0.70369800
121MP0004133_heterotaxia0.70309590
122MP0002161_abnormal_fertility/fecundity0.70032454
123MP0003221_abnormal_cardiomyocyte_apopto0.69936987
124MP0003698_abnormal_male_reproductive0.69924725
125MP0001929_abnormal_gametogenesis0.69544808
126MP0000377_abnormal_hair_follicle0.69386963
127MP0000266_abnormal_heart_morphology0.69293888
128MP0000049_abnormal_middle_ear0.68991448
129MP0002116_abnormal_craniofacial_bone0.68991215
130MP0010630_abnormal_cardiac_muscle0.68692884
131MP0002114_abnormal_axial_skeleton0.68583871
132MP0005647_abnormal_sex_gland0.67301054
133MP0005408_hypopigmentation0.67163019
134MP0002233_abnormal_nose_morphology0.65062573

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)3.68461497
2Microvesicular hepatic steatosis (HP:0001414)3.64387023
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56066623
4Short 4th metacarpal (HP:0010044)3.56066623
5Birth length less than 3rd percentile (HP:0003561)3.30884818
6Abnormality of the fingertips (HP:0001211)3.21220763
7Homocystinuria (HP:0002156)3.15484631
8Abnormality of homocysteine metabolism (HP:0010919)3.15484631
9Volvulus (HP:0002580)3.08892001
10Reticulocytopenia (HP:0001896)3.06748925
11Long eyelashes (HP:0000527)3.05426600
12Ectopic kidney (HP:0000086)3.05417023
13Chromsome breakage (HP:0040012)3.04229184
14Ependymoma (HP:0002888)3.00685606
15Increased nuchal translucency (HP:0010880)2.96597255
16Sparse lateral eyebrow (HP:0005338)2.84052801
17Patellar aplasia (HP:0006443)2.74365176
18Progressive muscle weakness (HP:0003323)2.72017719
19Proximal placement of thumb (HP:0009623)2.71667423
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68931243
21Abnormal gallbladder physiology (HP:0012438)2.65409550
22Cholecystitis (HP:0001082)2.65409550
23Colon cancer (HP:0003003)2.64278461
24Medulloblastoma (HP:0002885)2.63402569
25Abnormality of the 4th metacarpal (HP:0010012)2.62138653
26Prominent nose (HP:0000448)2.61592392
27Neoplasm of the oral cavity (HP:0100649)2.59669594
28Aplasia/Hypoplasia of the patella (HP:0006498)2.58135369
29Missing ribs (HP:0000921)2.57654572
30Abnormal number of incisors (HP:0011064)2.56226539
31Breast hypoplasia (HP:0003187)2.55357272
32Deviation of the thumb (HP:0009603)2.54862476
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54421041
34High anterior hairline (HP:0009890)2.53296538
35Pseudobulbar signs (HP:0002200)2.51125743
36Supernumerary bones of the axial skeleton (HP:0009144)2.46383374
37Rib fusion (HP:0000902)2.45871103
38Multiple enchondromatosis (HP:0005701)2.45781985
39Absent radius (HP:0003974)2.45562643
40Abnormality of methionine metabolism (HP:0010901)2.43428654
41Degeneration of anterior horn cells (HP:0002398)2.39025455
42Abnormality of the anterior horn cell (HP:0006802)2.39025455
43Aplasia involving forearm bones (HP:0009822)2.36047510
44Absent forearm bone (HP:0003953)2.36047510
45Abnormality of chromosome stability (HP:0003220)2.34448078
46Supernumerary ribs (HP:0005815)2.32003544
47Premature ovarian failure (HP:0008209)2.31472449
48Skin tags (HP:0010609)2.29431551
49Overlapping toe (HP:0001845)2.26208775
50Asplenia (HP:0001746)2.25747718
51Atresia of the external auditory canal (HP:0000413)2.25225117
52Depressed nasal tip (HP:0000437)2.22710317
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.20477862
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.19449424
55Secondary amenorrhea (HP:0000869)2.19205837
56Upper motor neuron abnormality (HP:0002127)2.15333174
57Abnormality of the lower motor neuron (HP:0002366)2.15265163
58Esophageal atresia (HP:0002032)2.15148119
59Renal duplication (HP:0000075)2.14261686
60Supernumerary spleens (HP:0009799)2.13711861
61Meckel diverticulum (HP:0002245)2.12962389
62Progressive external ophthalmoplegia (HP:0000590)2.12141615
63Basal cell carcinoma (HP:0002671)2.12048757
64Renal cell carcinoma (HP:0005584)2.11648388
65Facial hemangioma (HP:0000329)2.11127581
66Absent epiphyses (HP:0010577)2.10692202
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.10692202
68Trigonocephaly (HP:0000243)2.10541964
69Anal stenosis (HP:0002025)2.09239132
70Abnormality of abdominal situs (HP:0011620)2.08837639
71Abdominal situs inversus (HP:0003363)2.08837639
72Abnormal lung lobation (HP:0002101)2.08813750
73Abnormality of cochlea (HP:0000375)2.07684560
74Preauricular skin tag (HP:0000384)2.07369719
75Hypoplastic labia majora (HP:0000059)2.06171228
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05531000
77Cutis marmorata (HP:0000965)2.05116449
78Cortical dysplasia (HP:0002539)2.04702872
79Septate vagina (HP:0001153)2.04306011
80Blepharitis (HP:0000498)2.03756243
81Choanal atresia (HP:0000453)2.02679440
82Skull defect (HP:0001362)2.02659087
83Abnormality of glycolysis (HP:0004366)2.01254446
84Acute myeloid leukemia (HP:0004808)2.00256927
85Myelodysplasia (HP:0002863)2.00121833
86Aplasia/Hypoplasia of the sternum (HP:0006714)1.99415313
87Abnormality of the ileum (HP:0001549)1.99306197
88Broad thumb (HP:0011304)1.98971069
8911 pairs of ribs (HP:0000878)1.98801460
90Impulsivity (HP:0100710)1.98352784
91Horseshoe kidney (HP:0000085)1.98016232
92Abnormality of the parathyroid morphology (HP:0011766)1.97796111
93Squamous cell carcinoma (HP:0002860)1.97687698
94Abnormality of DNA repair (HP:0003254)1.91718106
95Astrocytoma (HP:0009592)1.91343214
96Abnormality of the astrocytes (HP:0100707)1.91343214
97Neoplasm of striated muscle (HP:0009728)1.90749959
98Abnormality of the labia minora (HP:0012880)1.90440687
99Oligodactyly (HP:0012165)1.90348016
100Shallow orbits (HP:0000586)1.89832200
101Capillary hemangiomas (HP:0005306)1.89119007
102Abnormal umbilical cord blood vessels (HP:0011403)1.88089487
103Single umbilical artery (HP:0001195)1.88089487
104Abnormality of the fetal cardiovascular system (HP:0010948)1.88089487
105Shawl scrotum (HP:0000049)1.87648629
106Embryonal neoplasm (HP:0002898)1.87278249
107Impaired proprioception (HP:0010831)1.87147342
108Hyperglycinemia (HP:0002154)1.86955425
109Urethral obstruction (HP:0000796)1.86739639
110Abnormal glycosylation (HP:0012345)1.85609687
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85609687
112Abnormal protein N-linked glycosylation (HP:0012347)1.85609687
113Abnormal protein glycosylation (HP:0012346)1.85609687
114Sloping forehead (HP:0000340)1.84120953
115Small epiphyses (HP:0010585)1.82580708
116Embryonal renal neoplasm (HP:0011794)1.82472692
117Spastic diplegia (HP:0001264)1.82446678
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.82297950
119Abnormality of the preputium (HP:0100587)1.81415501
120Small intestinal stenosis (HP:0012848)1.81396542
121Duodenal stenosis (HP:0100867)1.81396542
122Gastrointestinal carcinoma (HP:0002672)1.81295570
123Malignant gastrointestinal tract tumors (HP:0006749)1.81295570
124Carpal bone hypoplasia (HP:0001498)1.80901803
125Duplicated collecting system (HP:0000081)1.80884014
126Abnormality of the labia majora (HP:0012881)1.80666967
127Type I transferrin isoform profile (HP:0003642)1.80046387
128Hemivertebrae (HP:0002937)1.79846911
129Optic nerve coloboma (HP:0000588)1.79488696
130Abnormality of the carotid arteries (HP:0005344)1.78001478
131Progressive hearing impairment (HP:0001730)1.77715508
132Abnormality of the umbilical cord (HP:0010881)1.77581600
133Abnormality of the duodenum (HP:0002246)1.77166353
134Trismus (HP:0000211)1.76769302
135Abnormality of chromosome segregation (HP:0002916)1.76279081
136Ragged-red muscle fibers (HP:0003200)1.74871557
137Megaloblastic anemia (HP:0001889)1.74792539
138Broad phalanges of the hand (HP:0009768)1.74365478
139Hyperacusis (HP:0010780)1.74204984
140Asymmetry of the thorax (HP:0001555)1.73772422
141Broad alveolar ridges (HP:0000187)1.73151955
142Amaurosis fugax (HP:0100576)1.72768092
143Microtia (HP:0008551)1.71286303
144Overriding aorta (HP:0002623)1.71229665
145Sandal gap (HP:0001852)1.70830242
146Uterine leiomyosarcoma (HP:0002891)1.70315591
147Leiomyosarcoma (HP:0100243)1.70315591
148Abnormality of the diencephalon (HP:0010662)1.69637099
149Hyperglycinuria (HP:0003108)1.68711139
150Gastrointestinal atresia (HP:0002589)1.68644264
151Glioma (HP:0009733)1.68534687
152Low anterior hairline (HP:0000294)1.68074225
153Nephroblastoma (Wilms tumor) (HP:0002667)1.67822657
154Obsessive-compulsive behavior (HP:0000722)1.67526512
155Cafe-au-lait spot (HP:0000957)1.67339765
156Hypoplasia of the radius (HP:0002984)1.66325877
157Rhabdomyosarcoma (HP:0002859)1.66211666
158Intestinal fistula (HP:0100819)1.65233581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.94695070
2CDC73.82271732
3CDK123.43219549
4WEE13.32449922
5PBK2.99225279
6MKNK12.78411697
7NEK22.57576547
8NME22.48414949
9BUB12.45301419
10EEF2K2.43342464
11BRD42.41382860
12TTK2.32930438
13VRK22.23569397
14STK102.15700067
15MKNK22.11438314
16TAF12.11306255
17CDK71.97373044
18SRPK11.95041869
19PASK1.91349537
20MAP3K101.85972291
21ICK1.85520236
22CDK41.79795032
23RPS6KB21.77011908
24ATR1.68095385
25ZAK1.65362336
26LATS11.60180901
27PLK41.54053988
28FGFR41.53754864
29NME11.53177734
30PNCK1.50358963
31TGFBR11.44502586
32CDK61.44373892
33CHEK11.44027855
34CHEK21.41986814
35PLK11.41862380
36DYRK31.40019334
37AURKB1.39874054
38MAP4K11.39630121
39PTK61.34247927
40STK31.32230410
41MAP3K81.22526111
42ACVR1B1.21469880
43CAMK1G1.20119566
44SCYL21.19231082
45PKN21.18430815
46TSSK61.17804577
47CAMK1D1.16730986
48BRSK21.14506890
49STK41.13272481
50MTOR1.12520810
51CDK21.05140528
52ATM1.03041312
53TRIM281.02844862
54MST1R1.01819335
55RPS6KA40.99631842
56PLK30.99315576
57MELK0.98976577
58CLK10.97721410
59TIE10.96112332
60PAK40.92041301
61EIF2AK30.90258238
62ALK0.88771395
63SIK30.88410418
64BMX0.85644572
65TESK20.85472548
66CDK10.82278570
67LRRK20.81863303
68FGFR20.79707594
69EIF2AK10.79433224
70CSF1R0.77252294
71PIM10.77121327
72LMTK20.76538777
73BRAF0.74680540
74CSNK1A1L0.67677138
75EIF2AK20.67501679
76TRIB30.66746477
77PRPF4B0.65758100
78FLT30.65285367
79CSNK1D0.65245175
80PAK20.64922655
81VRK10.63348469
82MAPK110.63054184
83IRAK30.61871817
84SIK10.61408567
85FGFR10.60896514
86PDK20.60498186
87EPHA20.57616659
88CDK80.56920350
89NEK10.56766496
90CDK90.55607012
91AURKA0.55426888
92MAPK140.55172564
93BTK0.54497433
94MAPK10.53915113
95TGFBR20.53143639
96MET0.53062769
97EPHB10.52052334
98PIM20.51669316
99MAP2K30.51459282
100CSNK2A20.51436514
101CSNK1E0.51021779
102TYK20.50802587
103ARAF0.50637291
104PRKDC0.50248848
105PAK10.49315013
106ERBB20.44620461
107GSK3B0.43856572
108CHUK0.43643238
109JAK30.42624997
110TAOK10.41543637
111DAPK10.41057297
112CSNK1G10.40566759
113AKT20.40270825
114ERBB40.40226742
115PRKCI0.40077697
116RPS6KB10.38433284
117MAP2K20.37913386
118CSNK1G30.37899135
119MAP3K70.37726944
120TYRO30.37610984
121AKT10.36990702
122PRKG20.36477525
123NUAK10.33428477
124MARK30.33410319
125BRSK10.33087000
126CSNK2A10.31915323
127PDGFRB0.31874024
128RAF10.30734011
129RPS6KA10.30214306
130CCNB10.29779168
131BCR0.28807809

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24915476
2Mismatch repair_Homo sapiens_hsa034303.90029777
3Spliceosome_Homo sapiens_hsa030403.17371646
4Cell cycle_Homo sapiens_hsa041103.14232225
5Non-homologous end-joining_Homo sapiens_hsa034503.10313421
6RNA transport_Homo sapiens_hsa030132.94624020
7Base excision repair_Homo sapiens_hsa034102.80087133
8Homologous recombination_Homo sapiens_hsa034402.59483575
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57600054
10One carbon pool by folate_Homo sapiens_hsa006702.43327789
11RNA polymerase_Homo sapiens_hsa030202.41733309
12Nucleotide excision repair_Homo sapiens_hsa034202.27713142
13mRNA surveillance pathway_Homo sapiens_hsa030152.18991137
14Fanconi anemia pathway_Homo sapiens_hsa034602.10567906
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95134887
16Proteasome_Homo sapiens_hsa030501.94339993
17RNA degradation_Homo sapiens_hsa030181.91491493
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91082477
19Lysine degradation_Homo sapiens_hsa003101.79617825
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75836706
21Ribosome_Homo sapiens_hsa030101.74244743
22p53 signaling pathway_Homo sapiens_hsa041151.56090986
23Selenocompound metabolism_Homo sapiens_hsa004501.52883035
24Carbon metabolism_Homo sapiens_hsa012001.51548232
25Pyrimidine metabolism_Homo sapiens_hsa002401.49610531
26Notch signaling pathway_Homo sapiens_hsa043301.49465029
27MicroRNAs in cancer_Homo sapiens_hsa052061.41313277
28Basal cell carcinoma_Homo sapiens_hsa052171.38577940
29Basal transcription factors_Homo sapiens_hsa030221.32769263
30Small cell lung cancer_Homo sapiens_hsa052221.21777184
31Herpes simplex infection_Homo sapiens_hsa051681.19659690
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15168864
33Sulfur relay system_Homo sapiens_hsa041221.14847051
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14613759
35N-Glycan biosynthesis_Homo sapiens_hsa005101.14570079
36Fatty acid elongation_Homo sapiens_hsa000621.13815418
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10048630
38Chronic myeloid leukemia_Homo sapiens_hsa052201.09470405
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07738163
40Epstein-Barr virus infection_Homo sapiens_hsa051691.06482436
41TGF-beta signaling pathway_Homo sapiens_hsa043501.04560340
42HTLV-I infection_Homo sapiens_hsa051661.03042130
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02131095
44Pyruvate metabolism_Homo sapiens_hsa006201.00022084
45Viral carcinogenesis_Homo sapiens_hsa052030.99652072
46Prostate cancer_Homo sapiens_hsa052150.98836705
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97434038
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96455953
49Fructose and mannose metabolism_Homo sapiens_hsa000510.95898183
50Primary immunodeficiency_Homo sapiens_hsa053400.93881613
51Oocyte meiosis_Homo sapiens_hsa041140.92224151
52Colorectal cancer_Homo sapiens_hsa052100.92145922
53Hedgehog signaling pathway_Homo sapiens_hsa043400.91363868
54Hippo signaling pathway_Homo sapiens_hsa043900.91162251
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84347729
56Glutathione metabolism_Homo sapiens_hsa004800.83371300
57B cell receptor signaling pathway_Homo sapiens_hsa046620.82711488
58Biosynthesis of amino acids_Homo sapiens_hsa012300.74704358
59Acute myeloid leukemia_Homo sapiens_hsa052210.72096399
60Fatty acid metabolism_Homo sapiens_hsa012120.71692835
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.69697998
62Pathways in cancer_Homo sapiens_hsa052000.67809901
63Adherens junction_Homo sapiens_hsa045200.67429764
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67327758
65Non-small cell lung cancer_Homo sapiens_hsa052230.65396776
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64880249
67Galactose metabolism_Homo sapiens_hsa000520.64859687
68Purine metabolism_Homo sapiens_hsa002300.63489920
69Hepatitis B_Homo sapiens_hsa051610.62332101
70mTOR signaling pathway_Homo sapiens_hsa041500.61274533
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.60234272
72Pancreatic cancer_Homo sapiens_hsa052120.60183390
73Vitamin B6 metabolism_Homo sapiens_hsa007500.59758825
74Folate biosynthesis_Homo sapiens_hsa007900.58240423
75Arginine and proline metabolism_Homo sapiens_hsa003300.58205798
76Viral myocarditis_Homo sapiens_hsa054160.57756359
77Thyroid cancer_Homo sapiens_hsa052160.57681194
78Endometrial cancer_Homo sapiens_hsa052130.56504754
79Renal cell carcinoma_Homo sapiens_hsa052110.56256362
80Pentose phosphate pathway_Homo sapiens_hsa000300.55692362
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54715700
82Antigen processing and presentation_Homo sapiens_hsa046120.53877466
83Proteoglycans in cancer_Homo sapiens_hsa052050.53032304
84Wnt signaling pathway_Homo sapiens_hsa043100.52247126
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.52064394
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50262642
87Arginine biosynthesis_Homo sapiens_hsa002200.49563919
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46750435
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45120337
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44991187
91Steroid biosynthesis_Homo sapiens_hsa001000.44962975
92Vitamin digestion and absorption_Homo sapiens_hsa049770.44247366
93T cell receptor signaling pathway_Homo sapiens_hsa046600.44138210
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.43539817
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.43264285
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42724586
97AMPK signaling pathway_Homo sapiens_hsa041520.42620554
98Bladder cancer_Homo sapiens_hsa052190.41403135
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40824290
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.39889510
101Insulin resistance_Homo sapiens_hsa049310.38196539
102Metabolic pathways_Homo sapiens_hsa011000.37972030
103Propanoate metabolism_Homo sapiens_hsa006400.36147004
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35846911
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35687276
106FoxO signaling pathway_Homo sapiens_hsa040680.35437343
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35202363
108Measles_Homo sapiens_hsa051620.34929682
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.34334918
110Insulin signaling pathway_Homo sapiens_hsa049100.33711443
111Fatty acid biosynthesis_Homo sapiens_hsa000610.33279469
112Inositol phosphate metabolism_Homo sapiens_hsa005620.33044441
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32937146
114Apoptosis_Homo sapiens_hsa042100.31726487
115Glucagon signaling pathway_Homo sapiens_hsa049220.31187689
116Systemic lupus erythematosus_Homo sapiens_hsa053220.27476458
117Tight junction_Homo sapiens_hsa045300.26544761
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26132751
119Focal adhesion_Homo sapiens_hsa045100.24423239
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.24387273
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24377660
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23551576
123HIF-1 signaling pathway_Homo sapiens_hsa040660.22475242
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21931354
125Shigellosis_Homo sapiens_hsa051310.21862754
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21004756
127Dorso-ventral axis formation_Homo sapiens_hsa043200.20606388
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19646965
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.19168395
130Alcoholism_Homo sapiens_hsa050340.19136771
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.18705469
132Melanoma_Homo sapiens_hsa052180.18486636
133Hematopoietic cell lineage_Homo sapiens_hsa046400.17828734

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