GTF3C3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.42888154
2DNA synthesis involved in DNA repair (GO:0000731)5.17465760
3nuclear pore organization (GO:0006999)4.90968571
4mitotic metaphase plate congression (GO:0007080)4.48755151
5chromosome organization involved in meiosis (GO:0070192)4.43761725
6nuclear pore complex assembly (GO:0051292)4.33191760
7resolution of meiotic recombination intermediates (GO:0000712)4.03270907
8kinetochore organization (GO:0051383)4.01293388
9sister chromatid cohesion (GO:0007062)4.01141458
10metaphase plate congression (GO:0051310)3.98388355
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.92549687
12regulation of mitotic spindle checkpoint (GO:1903504)3.92549687
13establishment of chromosome localization (GO:0051303)3.91053092
14chromatin remodeling at centromere (GO:0031055)3.86784940
15non-recombinational repair (GO:0000726)3.86451223
16double-strand break repair via nonhomologous end joining (GO:0006303)3.86451223
17CENP-A containing nucleosome assembly (GO:0034080)3.84856769
18DNA double-strand break processing (GO:0000729)3.84474197
19piRNA metabolic process (GO:0034587)3.82641112
20purine nucleobase biosynthetic process (GO:0009113)3.81339310
21microtubule depolymerization (GO:0007019)3.79569115
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74018753
23sister chromatid segregation (GO:0000819)3.72461896
24DNA replication checkpoint (GO:0000076)3.71156955
25mitotic sister chromatid segregation (GO:0000070)3.70636815
26mitotic chromosome condensation (GO:0007076)3.68749800
27establishment of integrated proviral latency (GO:0075713)3.65692075
28cullin deneddylation (GO:0010388)3.62869555
29protein localization to chromosome, centromeric region (GO:0071459)3.59856258
30meiotic chromosome segregation (GO:0045132)3.57354892
31negative regulation of dendrite morphogenesis (GO:0050774)3.55054495
32male meiosis I (GO:0007141)3.52241104
33pore complex assembly (GO:0046931)3.51309259
34regulation of helicase activity (GO:0051095)3.51084378
35proteasome assembly (GO:0043248)3.50807846
36IMP biosynthetic process (GO:0006188)3.39655984
37spindle checkpoint (GO:0031577)3.39197235
38paraxial mesoderm development (GO:0048339)3.39006230
39kinetochore assembly (GO:0051382)3.38593669
40nucleobase biosynthetic process (GO:0046112)3.36339063
41DNA unwinding involved in DNA replication (GO:0006268)3.35708242
42protein localization to chromosome (GO:0034502)3.33764665
43protein localization to kinetochore (GO:0034501)3.30917750
44mitotic nuclear envelope disassembly (GO:0007077)3.29326488
45protein deneddylation (GO:0000338)3.29155490
46DNA topological change (GO:0006265)3.26796034
47protein K6-linked ubiquitination (GO:0085020)3.25634652
48attachment of spindle microtubules to kinetochore (GO:0008608)3.25011714
49meiotic cell cycle process (GO:1903046)3.24623526
50histone H2A acetylation (GO:0043968)3.23967151
51maturation of 5.8S rRNA (GO:0000460)3.23337897
52DNA catabolic process, exonucleolytic (GO:0000738)3.21170898
53spindle assembly checkpoint (GO:0071173)3.19630985
54male meiosis (GO:0007140)3.18789397
55ribosome assembly (GO:0042255)3.17000203
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16086966
57DNA strand renaturation (GO:0000733)3.15722726
58IMP metabolic process (GO:0046040)3.15506150
59regulation of sister chromatid cohesion (GO:0007063)3.14994152
60histone exchange (GO:0043486)3.14121121
61reciprocal meiotic recombination (GO:0007131)3.13812309
62reciprocal DNA recombination (GO:0035825)3.13812309
63mitotic spindle checkpoint (GO:0071174)3.13758975
64DNA methylation involved in gamete generation (GO:0043046)3.13635848
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13123505
66negative regulation of sister chromatid segregation (GO:0033046)3.13123505
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.13123505
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13123505
69regulation of sister chromatid segregation (GO:0033045)3.12952774
70regulation of mitotic sister chromatid separation (GO:0010965)3.12952774
71regulation of mitotic sister chromatid segregation (GO:0033047)3.12952774
72meiosis I (GO:0007127)3.12323525
73RNA-dependent DNA replication (GO:0006278)3.11947182
74DNA replication-independent nucleosome assembly (GO:0006336)3.11881975
75DNA replication-independent nucleosome organization (GO:0034724)3.11881975
76mitotic spindle assembly checkpoint (GO:0007094)3.11519802
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10769987
787-methylguanosine mRNA capping (GO:0006370)3.10061955
79meiotic nuclear division (GO:0007126)3.08198346
80formation of translation preinitiation complex (GO:0001731)3.07415095
81regulation of centriole replication (GO:0046599)3.06524638
82negative regulation of chromosome segregation (GO:0051985)3.06433776
83deoxyribose phosphate biosynthetic process (GO:0046385)3.05537576
842-deoxyribonucleotide biosynthetic process (GO:0009265)3.05537576
85membrane disassembly (GO:0030397)3.04780514
86nuclear envelope disassembly (GO:0051081)3.04780514
87regulation of meiosis I (GO:0060631)3.04742004
88regulation of centrosome cycle (GO:0046605)3.04533622
897-methylguanosine RNA capping (GO:0009452)3.03787793
90RNA capping (GO:0036260)3.03787793
91inositol phosphate catabolic process (GO:0071545)3.03588697
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.02707208
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02620100
94regulation of DNA endoreduplication (GO:0032875)3.02213202
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.01382247
96deoxyribonucleotide biosynthetic process (GO:0009263)3.01188864
97somatic hypermutation of immunoglobulin genes (GO:0016446)3.00581975
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00581975
99DNA ligation (GO:0006266)2.97946144
100mitotic sister chromatid cohesion (GO:0007064)2.97291795
101telomere maintenance via telomere lengthening (GO:0010833)2.93633130
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.93552117
103DNA geometric change (GO:0032392)2.92994663
104regulation of spindle organization (GO:0090224)2.92851893
105synaptonemal complex assembly (GO:0007130)2.91554141
106chromosome organization (GO:0051276)2.91524082
107gene silencing by RNA (GO:0031047)2.90875748
108DNA duplex unwinding (GO:0032508)2.89764786
109positive regulation of chromosome segregation (GO:0051984)2.89083237
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88724963
111chromosome segregation (GO:0007059)2.88078282
112DNA replication initiation (GO:0006270)2.87507296
113mitotic recombination (GO:0006312)2.85108745
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84872454
115negative regulation of DNA repair (GO:0045738)2.84486623
116replication fork processing (GO:0031297)2.82347237
117ribosome biogenesis (GO:0042254)2.81911742
118regulation of centrosome duplication (GO:0010824)2.80869932
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80779565
120transcription initiation from RNA polymerase I promoter (GO:0006361)2.79921681
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79681465
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79681465
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.79681465
124DNA strand elongation involved in DNA replication (GO:0006271)2.79544296
125snRNA processing (GO:0016180)2.79531735
126regulation of chromosome segregation (GO:0051983)2.78100412
127transcription-coupled nucleotide-excision repair (GO:0006283)2.77246082
128telomere maintenance via semi-conservative replication (GO:0032201)2.77134332
129transcription elongation from RNA polymerase I promoter (GO:0006362)2.76980487
130viral mRNA export from host cell nucleus (GO:0046784)2.74237415
131regulation of transcription from RNA polymerase I promoter (GO:0006356)2.73698083
132telomere maintenance via recombination (GO:0000722)2.72997703
133protein-cofactor linkage (GO:0018065)2.71380997
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.71360006
135transcription from RNA polymerase I promoter (GO:0006360)2.69661277
136DNA strand elongation (GO:0022616)2.68221667
137signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67834277
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67834277
139mismatch repair (GO:0006298)2.67797621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84218094
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.80642706
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77518112
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46982805
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98543005
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.85991837
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.78642773
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71011809
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.69491158
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.69105960
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.50850516
12ELK1_19687146_ChIP-ChIP_HELA_Human2.47647226
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.40539364
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34583757
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31468642
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27807616
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23908564
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22512869
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20683263
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20426055
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15753499
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15541297
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.12529666
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06828167
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04289781
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85678431
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.85251749
28* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84774322
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.82982568
30* VDR_23849224_ChIP-Seq_CD4+_Human1.76047104
31FUS_26573619_Chip-Seq_HEK293_Human1.74518587
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74361755
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71867965
34EWS_26573619_Chip-Seq_HEK293_Human1.68680838
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.67307494
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65982173
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65144147
38GBX2_23144817_ChIP-Seq_PC3_Human1.63560764
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62554140
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62064012
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61739223
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60648007
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.59059235
44IGF1R_20145208_ChIP-Seq_DFB_Human1.56173647
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55707871
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54750809
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52665941
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.48811702
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48710435
50AR_21909140_ChIP-Seq_LNCAP_Human1.48191586
51* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47907283
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45124442
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43631231
54TAF15_26573619_Chip-Seq_HEK293_Human1.43084209
55* FLI1_27457419_Chip-Seq_LIVER_Mouse1.42075511
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41471120
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40618777
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.39695281
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39095831
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.38054141
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35189880
62ZNF274_21170338_ChIP-Seq_K562_Hela1.34875038
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28205632
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.26149931
65XRN2_22483619_ChIP-Seq_HELA_Human1.25133090
66* GABP_19822575_ChIP-Seq_HepG2_Human1.24453698
67* TTF2_22483619_ChIP-Seq_HELA_Human1.23039933
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22954673
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22591978
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22149631
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15288378
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14025825
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12998768
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.12696135
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.12368001
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12183998
77RNF2_27304074_Chip-Seq_NSC_Mouse1.11382511
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10675473
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08444658
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08353874
81P300_19829295_ChIP-Seq_ESCs_Human1.07137264
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06896662
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.05181279
84MYC_18940864_ChIP-ChIP_HL60_Human1.04592021
85* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04459607
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01464616
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00173791
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98512772
89* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91071180
90SOX9_26525672_Chip-Seq_HEART_Mouse0.90856316
91TFEB_21752829_ChIP-Seq_HELA_Human0.90707810
92* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90337192
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89912796
94* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89798856
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89690621
96VDR_22108803_ChIP-Seq_LS180_Human0.88955759
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88565039
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88321462
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87481733
100IRF1_19129219_ChIP-ChIP_H3396_Human0.85360829
101WT1_19549856_ChIP-ChIP_CCG9911_Human0.85299964
102CIITA_25753668_ChIP-Seq_RAJI_Human0.85202861
103* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84292973
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.82833200
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81993217
106* JUN_21703547_ChIP-Seq_K562_Human0.81787286
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80319111
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.80161031
109* EZH2_27294783_Chip-Seq_NPCs_Mouse0.79277586
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78071017
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76010103
112KDM5A_27292631_Chip-Seq_BREAST_Human0.75765302
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75510072
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75367300
115ER_23166858_ChIP-Seq_MCF-7_Human0.74426064
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71439671
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70941307
118* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70523683
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70342314
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69612248
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69556127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.52871188
2MP0008877_abnormal_DNA_methylation3.36068430
3MP0003693_abnormal_embryo_hatching3.30356404
4MP0009697_abnormal_copulation2.88443042
5MP0003123_paternal_imprinting2.87103630
6MP0008058_abnormal_DNA_repair2.69837510
7MP0008057_abnormal_DNA_replication2.69024156
8MP0003787_abnormal_imprinting2.68189221
9MP0003077_abnormal_cell_cycle2.63771002
10MP0003121_genomic_imprinting2.59384369
11MP0008007_abnormal_cellular_replicative2.56503243
12MP0003111_abnormal_nucleus_morphology2.46374837
13MP0000566_synostosis2.45227073
14MP0004957_abnormal_blastocyst_morpholog2.41847564
15MP0003890_abnormal_embryonic-extraembry2.38507340
16MP0001986_abnormal_taste_sensitivity2.22617791
17MP0008932_abnormal_embryonic_tissue2.19376286
18MP0006292_abnormal_olfactory_placode2.11070772
19MP0008789_abnormal_olfactory_epithelium2.09103997
20MP0005367_renal/urinary_system_phenotyp1.94660248
21MP0000516_abnormal_urinary_system1.94660248
22MP0005499_abnormal_olfactory_system1.94554265
23MP0005394_taste/olfaction_phenotype1.94554265
24MP0002009_preneoplasia1.83986710
25MP0000569_abnormal_digit_pigmentation1.78428210
26MP0000372_irregular_coat_pigmentation1.78106327
27MP0002160_abnormal_reproductive_system1.78004866
28MP0003122_maternal_imprinting1.77925622
29MP0005171_absent_coat_pigmentation1.77649815
30MP0003941_abnormal_skin_development1.73238393
31MP0002751_abnormal_autonomic_nervous1.71447241
32MP0003950_abnormal_plasma_membrane1.70040552
33MP0002735_abnormal_chemical_nociception1.69100711
34MP0010030_abnormal_orbit_morphology1.59101595
35MP0001188_hyperpigmentation1.58567291
36MP0003786_premature_aging1.58431149
37MP0001984_abnormal_olfaction1.57566659
38MP0001661_extended_life_span1.57112660
39MP0005408_hypopigmentation1.48632903
40MP0006035_abnormal_mitochondrial_morpho1.46639938
41MP0000350_abnormal_cell_proliferation1.46541422
42MP0001293_anophthalmia1.45200027
43MP0001730_embryonic_growth_arrest1.44246170
44MP0009053_abnormal_anal_canal1.44169852
45MP0002396_abnormal_hematopoietic_system1.41960916
46MP0002938_white_spotting1.40977211
47MP0006072_abnormal_retinal_apoptosis1.38919968
48MP0000358_abnormal_cell_content/1.33712418
49MP0002837_dystrophic_cardiac_calcinosis1.27607068
50MP0010234_abnormal_vibrissa_follicle1.26621295
51MP0002653_abnormal_ependyma_morphology1.25224233
52MP0000015_abnormal_ear_pigmentation1.24674587
53MP0003698_abnormal_male_reproductive1.24426172
54MP0003315_abnormal_perineum_morphology1.18718990
55MP0005389_reproductive_system_phenotype1.18242607
56MP0001672_abnormal_embryogenesis/_devel1.17359038
57MP0005380_embryogenesis_phenotype1.17359038
58MP0010678_abnormal_skin_adnexa1.16533072
59MP0004133_heterotaxia1.13716925
60MP0003937_abnormal_limbs/digits/tail_de1.12844432
61MP0002877_abnormal_melanocyte_morpholog1.12270337
62MP0010307_abnormal_tumor_latency1.11829230
63MP0010352_gastrointestinal_tract_polyps1.10120579
64MP0009703_decreased_birth_body1.09059246
65MP0002233_abnormal_nose_morphology1.08801587
66MP0002736_abnormal_nociception_after1.08333901
67MP0001697_abnormal_embryo_size1.08239922
68MP0000383_abnormal_hair_follicle1.07739075
69MP0003221_abnormal_cardiomyocyte_apopto1.07190471
70MP0003385_abnormal_body_wall1.05484663
71MP0002085_abnormal_embryonic_tissue1.03438413
72MP0004782_abnormal_surfactant_physiolog1.01716392
73MP0005220_abnormal_exocrine_pancreas1.00904495
74MP0002210_abnormal_sex_determination1.00609492
75MP0003984_embryonic_growth_retardation1.00069502
76MP0002697_abnormal_eye_size1.00066980
77MP0006276_abnormal_autonomic_nervous0.99150608
78MP0005646_abnormal_pituitary_gland0.99028350
79MP0002088_abnormal_embryonic_growth/wei0.98815784
80MP0002095_abnormal_skin_pigmentation0.96941825
81MP0009672_abnormal_birth_weight0.96587180
82MP0002084_abnormal_developmental_patter0.96330170
83MP0004215_abnormal_myocardial_fiber0.94394330
84MP0001119_abnormal_female_reproductive0.91578893
85MP0001968_abnormal_touch/_nociception0.90837673
86MP0001186_pigmentation_phenotype0.89793838
87MP0003567_abnormal_fetal_cardiomyocyte0.88276443
88MP0004270_analgesia0.87229368
89MP0003755_abnormal_palate_morphology0.86956506
90MP0008995_early_reproductive_senescence0.86316041
91MP0001485_abnormal_pinna_reflex0.86191963
92MP0002080_prenatal_lethality0.85062702
93MP0002161_abnormal_fertility/fecundity0.83987915
94MP0001286_abnormal_eye_development0.83611418
95MP0002177_abnormal_outer_ear0.83502358
96MP0001529_abnormal_vocalization0.83470323
97MP0004197_abnormal_fetal_growth/weight/0.82795579
98MP0002184_abnormal_innervation0.82038197
99MP0002734_abnormal_mechanical_nocicepti0.81934482
100MP0003718_maternal_effect0.81824529
101MP0002086_abnormal_extraembryonic_tissu0.81820046
102MP0000313_abnormal_cell_death0.81315790
103MP0000049_abnormal_middle_ear0.81257823
104MP0003699_abnormal_female_reproductive0.81093224
105MP0003861_abnormal_nervous_system0.80746980
106MP0003943_abnormal_hepatobiliary_system0.80510986
107MP0000427_abnormal_hair_cycle0.79699440
108MP0000647_abnormal_sebaceous_gland0.78330680
109MP0000778_abnormal_nervous_system0.77686684
110MP0003942_abnormal_urinary_system0.76956011
111MP0002163_abnormal_gland_morphology0.76206849
112MP0001177_atelectasis0.76177323
113MP0001145_abnormal_male_reproductive0.75550583
114MP0003806_abnormal_nucleotide_metabolis0.75143370
115MP0004808_abnormal_hematopoietic_stem0.74391360
116MP0005395_other_phenotype0.74363530
117MP0002075_abnormal_coat/hair_pigmentati0.72410278
118MP0000653_abnormal_sex_gland0.72385971
119MP0006036_abnormal_mitochondrial_physio0.70973278
120MP0002102_abnormal_ear_morphology0.70754874
121MP0001764_abnormal_homeostasis0.70504403
122MP0002090_abnormal_vision0.70390669
123MP0005253_abnormal_eye_physiology0.69580097
124MP0005391_vision/eye_phenotype0.69338852
125MP0001919_abnormal_reproductive_system0.68947053
126MP0000678_abnormal_parathyroid_gland0.68284971
127MP0001929_abnormal_gametogenesis0.67518697
128MP0005384_cellular_phenotype0.66791527
129MP0003936_abnormal_reproductive_system0.65628382
130MP0002092_abnormal_eye_morphology0.65554098
131MP0004147_increased_porphyrin_level0.64173187
132MP0002019_abnormal_tumor_incidence0.63829514
133MP0003119_abnormal_digestive_system0.63115478
134MP0004233_abnormal_muscle_weight0.61018562
135MP0003195_calcinosis0.59959619
136MP0001299_abnormal_eye_distance/0.59537458
137MP0002111_abnormal_tail_morphology0.59490918
138MP0003935_abnormal_craniofacial_develop0.59316809

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.83268813
2Birth length less than 3rd percentile (HP:0003561)3.69966173
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63303372
4Abnormality of the labia minora (HP:0012880)3.34936293
5Increased nuchal translucency (HP:0010880)3.12015972
6Supernumerary spleens (HP:0009799)2.86503512
7Nephroblastoma (Wilms tumor) (HP:0002667)2.85111022
8Papillary thyroid carcinoma (HP:0002895)2.79721659
9Embryonal renal neoplasm (HP:0011794)2.78866753
10Abnormality of chromosome stability (HP:0003220)2.78325669
11Pancreatic fibrosis (HP:0100732)2.71664718
12Thyroid carcinoma (HP:0002890)2.68541800
13Abnormal lung lobation (HP:0002101)2.66613710
14Facial cleft (HP:0002006)2.66336384
15Patellar aplasia (HP:0006443)2.64367985
16Asymmetry of the thorax (HP:0001555)2.63965182
17Pancreatic islet-cell hyperplasia (HP:0004510)2.59915609
18Hypothermia (HP:0002045)2.59137762
19Ectopic kidney (HP:0000086)2.52993753
20True hermaphroditism (HP:0010459)2.52363390
21Meckel diverticulum (HP:0002245)2.51506328
22Agnosia (HP:0010524)2.45743693
23Aplasia/Hypoplasia of the patella (HP:0006498)2.45374454
24Abnormality of methionine metabolism (HP:0010901)2.44010084
25Gonadotropin excess (HP:0000837)2.42965907
26Increased serum pyruvate (HP:0003542)2.42289381
27Medulloblastoma (HP:0002885)2.42267755
28Abnormality of the ileum (HP:0001549)2.38919239
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.38812910
30Oligodactyly (hands) (HP:0001180)2.36710560
31Volvulus (HP:0002580)2.36188532
32Rectal fistula (HP:0100590)2.34648718
33Rectovaginal fistula (HP:0000143)2.34648718
34Postaxial foot polydactyly (HP:0001830)2.28073180
35Abnormality of glycolysis (HP:0004366)2.27169071
36Preaxial hand polydactyly (HP:0001177)2.26794198
37Abnormality of the anterior horn cell (HP:0006802)2.25607917
38Degeneration of anterior horn cells (HP:0002398)2.25607917
39Small intestinal stenosis (HP:0012848)2.22575955
40Duodenal stenosis (HP:0100867)2.22575955
41Congenital primary aphakia (HP:0007707)2.19631306
42Rimmed vacuoles (HP:0003805)2.18904998
43Aplasia/Hypoplasia of the sternum (HP:0006714)2.18193155
44Abnormality of the preputium (HP:0100587)2.13752975
45Intestinal fistula (HP:0100819)2.13578156
46Abnormal hair whorl (HP:0010721)2.12548742
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.12539684
48Gait imbalance (HP:0002141)2.12459185
49Medial flaring of the eyebrow (HP:0010747)2.11895122
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.10167928
51Rhabdomyosarcoma (HP:0002859)2.09575115
52Breast hypoplasia (HP:0003187)2.08310306
53Short tibia (HP:0005736)2.06331424
54Cutaneous melanoma (HP:0012056)2.05871826
55Sloping forehead (HP:0000340)2.04529526
56Impulsivity (HP:0100710)2.04333215
57Absent radius (HP:0003974)2.04310569
58Absent thumb (HP:0009777)2.03522752
59Nephrogenic diabetes insipidus (HP:0009806)2.01890723
60Abnormality of the phalanges of the hallux (HP:0010057)2.01089257
61Abnormality of alanine metabolism (HP:0010916)2.00878655
62Hyperalaninemia (HP:0003348)2.00878655
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00878655
64Shoulder girdle muscle weakness (HP:0003547)2.00796141
65Hypoglycemic coma (HP:0001325)2.00549478
66Poor coordination (HP:0002370)2.00535972
67Capillary hemangiomas (HP:0005306)2.00500256
68Abnormal glycosylation (HP:0012345)2.00384801
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00384801
70Abnormal protein N-linked glycosylation (HP:0012347)2.00384801
71Abnormal protein glycosylation (HP:0012346)2.00384801
72Febrile seizures (HP:0002373)1.99959301
73Protruding tongue (HP:0010808)1.99824206
74Proximal tubulopathy (HP:0000114)1.98089047
75Horseshoe kidney (HP:0000085)1.98000837
76Microvesicular hepatic steatosis (HP:0001414)1.97095946
77Absent forearm bone (HP:0003953)1.95951557
78Aplasia involving forearm bones (HP:0009822)1.95951557
79Abnormality of the duodenum (HP:0002246)1.95391251
80Neoplasm of the colon (HP:0100273)1.95379710
81Microglossia (HP:0000171)1.94011477
82Overlapping toe (HP:0001845)1.92830460
83Absent eyebrow (HP:0002223)1.92134126
84Alveolar cell carcinoma (HP:0006519)1.91229392
85Hyperglycinemia (HP:0002154)1.91131627
86Proximal placement of thumb (HP:0009623)1.90049648
87Tongue fasciculations (HP:0001308)1.89324355
88Ependymoma (HP:0002888)1.88531010
89Embryonal neoplasm (HP:0002898)1.88269414
90Abnormality of DNA repair (HP:0003254)1.88065027
91Hyperinsulinemic hypoglycemia (HP:0000825)1.87960924
92Duplicated collecting system (HP:0000081)1.87564644
93Abnormality of the carotid arteries (HP:0005344)1.85190239
94Abnormality of the renal collecting system (HP:0004742)1.85037334
95Pancreatic cysts (HP:0001737)1.84730215
96Myelodysplasia (HP:0002863)1.84642479
97Tubulointerstitial nephritis (HP:0001970)1.84251774
98Optic nerve coloboma (HP:0000588)1.84101146
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84036281
100Genital tract atresia (HP:0001827)1.83728192
101Prominent metopic ridge (HP:0005487)1.83202210
102Colon cancer (HP:0003003)1.82630654
103Neoplasm of the adrenal cortex (HP:0100641)1.81805996
104Hypobetalipoproteinemia (HP:0003563)1.81334002
105Deviation of the thumb (HP:0009603)1.80548823
106Glioma (HP:0009733)1.80186671
107Vaginal fistula (HP:0004320)1.79980992
108Abnormality of endocrine pancreas physiology (HP:0012093)1.79680373
109Abnormality of the pancreatic islet cells (HP:0006476)1.79680373
110Facial hemangioma (HP:0000329)1.79029948
111Heterochromia iridis (HP:0001100)1.77814064
112Long foot (HP:0001833)1.77762620
113Intestinal atresia (HP:0011100)1.77427587
114Cafe-au-lait spot (HP:0000957)1.77353913
115Abnormality of serum amino acid levels (HP:0003112)1.76857282
116Postnatal microcephaly (HP:0005484)1.76353733
117Fibular hypoplasia (HP:0003038)1.75428764
118Median cleft lip (HP:0000161)1.74904625
119Abnormality of the pons (HP:0007361)1.74418027
120Neoplasm of the tracheobronchial system (HP:0100552)1.73652716
121Curly hair (HP:0002212)1.73306635
122Postaxial hand polydactyly (HP:0001162)1.72758245
123Abnormality of the metopic suture (HP:0005556)1.72330259
124Renal hypoplasia (HP:0000089)1.72046667
125Aqueductal stenosis (HP:0002410)1.71981356
126Type I transferrin isoform profile (HP:0003642)1.70699670
127Hypoglycemic seizures (HP:0002173)1.69555150
128Clubbing of toes (HP:0100760)1.69283642
129Hepatoblastoma (HP:0002884)1.69015641
130Bifid tongue (HP:0010297)1.69008827
131Renal cortical cysts (HP:0000803)1.68994595
132Triphalangeal thumb (HP:0001199)1.68169410
133Abnormality of the renal cortex (HP:0011035)1.67463935
134Vaginal atresia (HP:0000148)1.67064185
135Long clavicles (HP:0000890)1.66900725
136Fibular aplasia (HP:0002990)1.66467065
137Spinal cord lesions (HP:0100561)1.66392301
138Syringomyelia (HP:0003396)1.66392301
139Diastasis recti (HP:0001540)1.66316310
140Deep philtrum (HP:0002002)1.66284330
141Cystic hygroma (HP:0000476)1.65765028
142Neuroblastoma (HP:0003006)1.65123081
143Primitive neuroectodermal tumor (HP:0030065)1.65123081
144Neuroblastic tumors (HP:0004376)1.65123081
145Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.65123081
146Progressive macrocephaly (HP:0004481)1.64566567
147Abnormality of the astrocytes (HP:0100707)1.64309600
148Astrocytoma (HP:0009592)1.64309600
149Abnormality of chromosome segregation (HP:0002916)1.64102734
150Chronic hepatic failure (HP:0100626)1.63146334
151Premature graying of hair (HP:0002216)1.62880677
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.62865559
153Oligodactyly (HP:0012165)1.62709478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.42842141
2CDC72.88510635
3ERBB32.86429559
4SRPK12.82552429
5ZAK2.80804153
6SIK32.70406505
7BUB12.55975328
8AKT32.50004222
9PNCK2.49134917
10MKNK12.38995327
11PLK32.38378024
12ACVR1B2.29537826
13EIF2AK12.27623051
14TSSK62.24542837
15FRK2.11123391
16MKNK22.03209965
17SGK21.94711673
18MAP2K71.92450580
19MST41.89010775
20PLK21.87574906
21BCR1.74070698
22MAP3K41.66465269
23BRD41.60169339
24STK38L1.59858091
25NEK11.59688464
26WEE11.58995813
27BMPR21.51010896
28CCNB11.50219159
29PLK41.50175112
30TRIM281.44594634
31MAP3K121.43272560
32PLK11.42902937
33NUAK11.42800111
34WNK31.40328343
35NEK61.28607668
36VRK11.28454732
37SGK4941.28204006
38SGK2231.28204006
39TAF11.27656930
40ATR1.27225100
41YES11.26527090
42PDK21.24313926
43MAP3K141.19424573
44NEK91.19248647
45CDK81.15496729
46BRAF1.14296353
47PRPF4B1.13992622
48BRSK21.12661138
49MAP4K21.12269447
50NTRK31.12089734
51STK241.11154615
52PBK1.10962317
53VRK21.10961637
54SGK31.10780518
55EIF2AK31.07080755
56TTK1.05814035
57CDK121.02155625
58STK161.00162377
59MINK10.99805453
60STK390.96264076
61MET0.96059157
62MAPK130.95397978
63AURKB0.93176381
64CHEK20.90138800
65RPS6KB10.88829281
66SCYL20.86217872
67ATM0.85584487
68FGFR20.85227102
69PASK0.84213140
70BRSK10.83445590
71CDK190.83277469
72CSNK1G10.82803276
73FLT30.82529098
74EEF2K0.81790763
75AURKA0.81768453
76EIF2AK20.76736080
77CHEK10.76672568
78WNK40.76467307
79NEK20.72332002
80CDK70.69632619
81OXSR10.69337022
82DAPK10.69148849
83FGFR30.67472896
84CDK60.66326778
85CAMK1G0.66229465
86DYRK30.66165025
87KSR10.64667511
88STK30.64355831
89TRPM70.63490468
90CSNK1G30.63465298
91CSNK1A1L0.62323442
92BMPR1B0.61842461
93TGFBR10.60672196
94MAPKAPK50.58120225
95NLK0.55513624
96CDK10.54816598
97CDK30.54476624
98CSNK1E0.53872907
99STK40.52566959
100DYRK20.52363732
101FGFR10.52147043
102CSNK2A10.52066031
103LATS10.51364622
104LIMK10.50993211
105MAP3K100.48805530
106CDK20.48755168
107MAP2K40.48160818
108ADRBK20.45819684
109PRKCG0.45503648
110PRKDC0.45267194
111ERBB40.44899795
112CSNK2A20.43319975
113ALK0.43240000
114CSNK1G20.42592294
115MYLK0.41158189
116MELK0.40041794
117MAP3K50.39046767
118CLK10.38891314
119PIM10.37787932
120RPS6KB20.36038907
121FER0.35262496
122CDK40.34355294
123AKT20.32971800
124TIE10.32560491
125OBSCN0.32390679
126ARAF0.30879573
127GRK50.29083824
128RPS6KA20.28388844
129RPS6KL10.28113586
130RPS6KC10.28113586
131RPS6KA60.27283955
132TESK10.26710616
133CHUK0.26413908
134MARK30.25443666
135RPS6KA40.23933193
136MAPK140.23503536

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.92613848
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74446496
3Proteasome_Homo sapiens_hsa030503.66003839
4DNA replication_Homo sapiens_hsa030303.53684413
5RNA polymerase_Homo sapiens_hsa030203.16761287
6Cell cycle_Homo sapiens_hsa041102.97864797
7RNA transport_Homo sapiens_hsa030132.81531940
8Base excision repair_Homo sapiens_hsa034102.78599420
9Non-homologous end-joining_Homo sapiens_hsa034502.76702603
10Nucleotide excision repair_Homo sapiens_hsa034202.74205661
11Homologous recombination_Homo sapiens_hsa034402.73482279
12Spliceosome_Homo sapiens_hsa030402.65997449
13Propanoate metabolism_Homo sapiens_hsa006402.53699605
14Basal transcription factors_Homo sapiens_hsa030222.49133278
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48635184
16Fanconi anemia pathway_Homo sapiens_hsa034602.33936900
17One carbon pool by folate_Homo sapiens_hsa006702.10789649
18RNA degradation_Homo sapiens_hsa030182.06550925
19Pyrimidine metabolism_Homo sapiens_hsa002401.90318637
20mRNA surveillance pathway_Homo sapiens_hsa030151.88551356
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88501931
22Steroid biosynthesis_Homo sapiens_hsa001001.72837759
23Selenocompound metabolism_Homo sapiens_hsa004501.66649555
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61592290
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60638403
26Oocyte meiosis_Homo sapiens_hsa041141.58957384
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53459804
28Pyruvate metabolism_Homo sapiens_hsa006201.49629386
29Purine metabolism_Homo sapiens_hsa002301.37736968
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32797320
31Epstein-Barr virus infection_Homo sapiens_hsa051691.27380555
32Fatty acid elongation_Homo sapiens_hsa000621.22390323
33p53 signaling pathway_Homo sapiens_hsa041151.21824379
34Systemic lupus erythematosus_Homo sapiens_hsa053221.17570170
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14265500
36Carbon metabolism_Homo sapiens_hsa012001.10751850
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09054274
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08692696
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06519803
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05765839
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04023273
42Fatty acid metabolism_Homo sapiens_hsa012121.03982294
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01917645
44Olfactory transduction_Homo sapiens_hsa047401.01366097
45Phototransduction_Homo sapiens_hsa047440.98211241
46Type I diabetes mellitus_Homo sapiens_hsa049400.96435923
47Biosynthesis of amino acids_Homo sapiens_hsa012300.95009420
48Thyroid cancer_Homo sapiens_hsa052160.91529760
49Synaptic vesicle cycle_Homo sapiens_hsa047210.87606011
50Huntingtons disease_Homo sapiens_hsa050160.86879254
51Lysine degradation_Homo sapiens_hsa003100.86484103
52Melanoma_Homo sapiens_hsa052180.85491423
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84920608
54Alcoholism_Homo sapiens_hsa050340.82155062
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80346623
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80155676
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79388067
58Butanoate metabolism_Homo sapiens_hsa006500.78805334
59Viral carcinogenesis_Homo sapiens_hsa052030.78606572
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78248816
61N-Glycan biosynthesis_Homo sapiens_hsa005100.75871682
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73307801
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73289776
64Endometrial cancer_Homo sapiens_hsa052130.72526591
65TGF-beta signaling pathway_Homo sapiens_hsa043500.70298873
66Folate biosynthesis_Homo sapiens_hsa007900.70064088
67Hippo signaling pathway_Homo sapiens_hsa043900.69637129
68Collecting duct acid secretion_Homo sapiens_hsa049660.68499986
69Peroxisome_Homo sapiens_hsa041460.67918578
70Allograft rejection_Homo sapiens_hsa053300.66928937
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66419936
72Legionellosis_Homo sapiens_hsa051340.65428321
73Vibrio cholerae infection_Homo sapiens_hsa051100.64259942
74Herpes simplex infection_Homo sapiens_hsa051680.63988548
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63733979
76Protein export_Homo sapiens_hsa030600.61154176
77Vitamin B6 metabolism_Homo sapiens_hsa007500.61027060
78Colorectal cancer_Homo sapiens_hsa052100.60838837
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59769686
80HTLV-I infection_Homo sapiens_hsa051660.56383514
81Fatty acid degradation_Homo sapiens_hsa000710.56236864
82MicroRNAs in cancer_Homo sapiens_hsa052060.54881105
83Autoimmune thyroid disease_Homo sapiens_hsa053200.54647790
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51717681
85Phagosome_Homo sapiens_hsa041450.50475107
86Prostate cancer_Homo sapiens_hsa052150.50470481
87Metabolic pathways_Homo sapiens_hsa011000.50009417
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49360405
89beta-Alanine metabolism_Homo sapiens_hsa004100.49143504
90Parkinsons disease_Homo sapiens_hsa050120.48747178
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46855335
92Basal cell carcinoma_Homo sapiens_hsa052170.46811896
93Rheumatoid arthritis_Homo sapiens_hsa053230.44739300
94Influenza A_Homo sapiens_hsa051640.43043056
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42985792
96Wnt signaling pathway_Homo sapiens_hsa043100.41043510
97Oxidative phosphorylation_Homo sapiens_hsa001900.40956622
98FoxO signaling pathway_Homo sapiens_hsa040680.40816170
99Glutathione metabolism_Homo sapiens_hsa004800.39320020
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38664745
101Adherens junction_Homo sapiens_hsa045200.38176920
102Hedgehog signaling pathway_Homo sapiens_hsa043400.36848180
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36429867
104Dopaminergic synapse_Homo sapiens_hsa047280.36109229
105Regulation of autophagy_Homo sapiens_hsa041400.35884220
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.35816818
107Long-term potentiation_Homo sapiens_hsa047200.35606403
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.35414330
109Serotonergic synapse_Homo sapiens_hsa047260.34065997
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.33682662
111Arginine and proline metabolism_Homo sapiens_hsa003300.33132670
112Hepatitis B_Homo sapiens_hsa051610.32768770
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32170509
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31428637
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.31300113
116Melanogenesis_Homo sapiens_hsa049160.31160803
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30839624
118Circadian rhythm_Homo sapiens_hsa047100.30807995
119Pathways in cancer_Homo sapiens_hsa052000.30728987
120HIF-1 signaling pathway_Homo sapiens_hsa040660.30428642
121Nicotine addiction_Homo sapiens_hsa050330.29481547
122Glioma_Homo sapiens_hsa052140.28414329
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.28221244
124Pentose phosphate pathway_Homo sapiens_hsa000300.28133655
125ErbB signaling pathway_Homo sapiens_hsa040120.27507096
126Shigellosis_Homo sapiens_hsa051310.27370810
127Measles_Homo sapiens_hsa051620.25884243
128Ribosome_Homo sapiens_hsa030100.25780599
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25664842
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25627462
131Taste transduction_Homo sapiens_hsa047420.24741634
132Fatty acid biosynthesis_Homo sapiens_hsa000610.23617092
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22728657
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21666683
135Prolactin signaling pathway_Homo sapiens_hsa049170.20697523
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20618003
137Tight junction_Homo sapiens_hsa045300.19382842
138Non-small cell lung cancer_Homo sapiens_hsa052230.19358281
139Sulfur metabolism_Homo sapiens_hsa009200.16053232
140Tryptophan metabolism_Homo sapiens_hsa003800.13945850
141Small cell lung cancer_Homo sapiens_hsa052220.13347841
142Sphingolipid metabolism_Homo sapiens_hsa006000.13067529
143Caffeine metabolism_Homo sapiens_hsa002320.11904574
144Inositol phosphate metabolism_Homo sapiens_hsa005620.11629781
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.10663825
146Retinol metabolism_Homo sapiens_hsa008300.08895577
147Vitamin digestion and absorption_Homo sapiens_hsa049770.05887275

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