GTF3C4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.72946804
2protein localization to kinetochore (GO:0034501)5.67653488
3pre-miRNA processing (GO:0031054)5.45263545
4nuclear pore organization (GO:0006999)5.29550461
5heterochromatin organization (GO:0070828)4.57256226
6DNA replication-dependent nucleosome organization (GO:0034723)4.52827728
7DNA replication-dependent nucleosome assembly (GO:0006335)4.52827728
8chromatin assembly (GO:0031497)4.52108759
9sister chromatid segregation (GO:0000819)4.39343524
10protein localization to chromosome, centromeric region (GO:0071459)4.35548441
11mitotic sister chromatid segregation (GO:0000070)4.25064524
12histone H4-K8 acetylation (GO:0043982)4.21352476
13histone H4-K5 acetylation (GO:0043981)4.21352476
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.16416449
15mitotic sister chromatid cohesion (GO:0007064)3.97898988
16DNA unwinding involved in DNA replication (GO:0006268)3.97402931
17pore complex assembly (GO:0046931)3.95015387
18mRNA stabilization (GO:0048255)3.90264383
19RNA stabilization (GO:0043489)3.90264383
20mitotic metaphase plate congression (GO:0007080)3.88195861
21regulation of telomere maintenance via telomerase (GO:0032210)3.83795596
22regulation of hippo signaling (GO:0035330)3.81895793
23cellular protein complex localization (GO:0034629)3.81502944
24negative regulation of cell cycle G2/M phase transition (GO:1902750)3.80325460
25NLS-bearing protein import into nucleus (GO:0006607)3.78832567
26protein complex localization (GO:0031503)3.77439386
27polyketide metabolic process (GO:0030638)3.74876544
28doxorubicin metabolic process (GO:0044598)3.74876544
29daunorubicin metabolic process (GO:0044597)3.74876544
30negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.74468062
31DNA replication initiation (GO:0006270)3.66686831
32mitotic chromosome condensation (GO:0007076)3.62804481
33DNA strand elongation involved in DNA replication (GO:0006271)3.61611815
34regulation of centriole replication (GO:0046599)3.60038865
35DNA topological change (GO:0006265)3.58008817
36DNA duplex unwinding (GO:0032508)3.57504864
37histone H4-K16 acetylation (GO:0043984)3.56894871
38DNA strand elongation (GO:0022616)3.54603096
39DNA geometric change (GO:0032392)3.54013388
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47503951
41negative regulation of histone methylation (GO:0031061)3.46308043
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.45043228
43histone H4-K12 acetylation (GO:0043983)3.39391921
44regulation of RNA export from nucleus (GO:0046831)3.39169030
45positive regulation of chromosome segregation (GO:0051984)3.37897059
46regulation of posttranscriptional gene silencing (GO:0060147)3.36375484
47regulation of gene silencing by miRNA (GO:0060964)3.36375484
48regulation of gene silencing by RNA (GO:0060966)3.36375484
49metaphase plate congression (GO:0051310)3.32204974
50negative regulation of epidermis development (GO:0045683)3.26349777
51folic acid-containing compound biosynthetic process (GO:0009396)3.22799038
52positive regulation of histone deacetylation (GO:0031065)3.22765779
53notochord development (GO:0030903)3.22593984
54maintenance of protein location in nucleus (GO:0051457)3.21920557
55regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20388360
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19826036
57polarized epithelial cell differentiation (GO:0030859)3.17860363
58negative regulation of DNA repair (GO:0045738)3.17815993
59glucocorticoid receptor signaling pathway (GO:0042921)3.15424595
60mitotic nuclear envelope disassembly (GO:0007077)3.14979606
61establishment of integrated proviral latency (GO:0075713)3.13475635
62regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.12082745
63somite rostral/caudal axis specification (GO:0032525)3.11246847
64histone H2A monoubiquitination (GO:0035518)3.09661140
65peptidyl-lysine dimethylation (GO:0018027)3.09553915
66paraxial mesoderm development (GO:0048339)3.08532614
67regulation of histone H3-K9 methylation (GO:0051570)3.08081394
68membrane disassembly (GO:0030397)3.07438421
69nuclear envelope disassembly (GO:0051081)3.07438421
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.03584800
71regulation of centrosome cycle (GO:0046605)3.02124364
72regulation of DNA endoreduplication (GO:0032875)3.01030503
73regulation of chromosome segregation (GO:0051983)3.00627066
74stress granule assembly (GO:0034063)2.98363909
75maternal placenta development (GO:0001893)2.97776476
76formation of translation preinitiation complex (GO:0001731)2.97166585
77primitive streak formation (GO:0090009)2.96838174
78telomere maintenance via semi-conservative replication (GO:0032201)2.96710678
79dosage compensation (GO:0007549)2.93918740
80regulation of centrosome duplication (GO:0010824)2.92374162
81regulation of response to osmotic stress (GO:0047484)2.91935503
82double-strand break repair via nonhomologous end joining (GO:0006303)2.90286965
83non-recombinational repair (GO:0000726)2.90286965
84dorsal/ventral axis specification (GO:0009950)2.89793028
85chromatin assembly or disassembly (GO:0006333)2.89349298
86protein-DNA complex disassembly (GO:0032986)2.88975065
87nucleosome disassembly (GO:0006337)2.88975065
88negative regulation of mRNA processing (GO:0050686)2.87648872
89IMP biosynthetic process (GO:0006188)2.86137532
90regulation of translational termination (GO:0006449)2.86131252
91negative regulation of cell size (GO:0045792)2.85247176
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.84685170
93positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84685170
94positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84685170
95nuclear envelope organization (GO:0006998)2.84284827
96sister chromatid cohesion (GO:0007062)2.84241655
97chromosome condensation (GO:0030261)2.83812163
98ribosome assembly (GO:0042255)2.82440475
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82117246
100DNA synthesis involved in DNA repair (GO:0000731)2.81388760
101protein localization to chromosome (GO:0034502)2.81244688
102regulation of mRNA stability (GO:0043488)2.80703378
103spindle assembly (GO:0051225)2.80661607
104negative regulation of telomerase activity (GO:0051974)2.79574177
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79300892
106positive regulation of DNA-dependent DNA replication (GO:2000105)2.79163993
107hippo signaling (GO:0035329)2.78037625
108negative regulation of mRNA metabolic process (GO:1903312)2.77907268
109establishment of chromosome localization (GO:0051303)2.75006744
110DNA packaging (GO:0006323)2.74751343
111negative regulation of chromosome segregation (GO:0051985)2.74534945
112chromatin remodeling at centromere (GO:0031055)2.73390366
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72803384
114intracellular estrogen receptor signaling pathway (GO:0030520)2.72653757
115positive regulation of SMAD protein import into nucleus (GO:0060391)2.72502368
116histone arginine methylation (GO:0034969)2.71987437
117DNA conformation change (GO:0071103)2.71871494
118CENP-A containing nucleosome assembly (GO:0034080)2.71803288
119DNA replication checkpoint (GO:0000076)2.71574434
120establishment of apical/basal cell polarity (GO:0035089)2.70935133
121peptidyl-arginine omega-N-methylation (GO:0035247)2.70464006
122chromosome segregation (GO:0007059)2.68588179
123regulation of spindle organization (GO:0090224)2.68249697
124regulation of nucleobase-containing compound transport (GO:0032239)2.67999593
125negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.67809345
126regulation of sister chromatid cohesion (GO:0007063)2.67694626
127hormone catabolic process (GO:0042447)2.67100034
128regulation of translational fidelity (GO:0006450)2.66603316
129positive regulation of protein deacetylation (GO:0090312)2.66400460
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64849272
131regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64849272
132attachment of spindle microtubules to kinetochore (GO:0008608)2.64346793
133spindle checkpoint (GO:0031577)2.63722034
134positive regulation of cell cycle checkpoint (GO:1901978)2.63456765
135mitotic recombination (GO:0006312)2.63175315
136corticosteroid receptor signaling pathway (GO:0031958)2.62265381
137regulation of mitotic spindle organization (GO:0060236)2.62131998
138mRNA transport (GO:0051028)2.61385763
139regulation of sister chromatid segregation (GO:0033045)2.61116420
140regulation of mitotic sister chromatid separation (GO:0010965)2.61116420
141regulation of mitotic sister chromatid segregation (GO:0033047)2.61116420
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.60391396
143negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.60182593
144negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.60182593
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.60182593
146negative regulation of mitotic sister chromatid separation (GO:2000816)2.60182593
147negative regulation of sister chromatid segregation (GO:0033046)2.60182593
148ATP-dependent chromatin remodeling (GO:0043044)2.60022971
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.59591980
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.59591980
151IMP metabolic process (GO:0046040)2.58363444
152regulation of translation in response to stress (GO:0043555)2.58008141
153protein export from nucleus (GO:0006611)2.57500685
154kinetochore organization (GO:0051383)2.57308772
155cytoplasmic mRNA processing body assembly (GO:0033962)2.56436441
156monoubiquitinated protein deubiquitination (GO:0035520)2.56424515
157mitotic spindle checkpoint (GO:0071174)2.56344149
158trophectodermal cell differentiation (GO:0001829)2.55668614
159mitotic spindle organization (GO:0007052)2.55587333
160peptidyl-arginine methylation (GO:0018216)2.55558023
161peptidyl-arginine N-methylation (GO:0035246)2.55558023
162regulation of RNA stability (GO:0043487)2.55071844
163negative regulation of RNA splicing (GO:0033119)2.54840541
164telomere maintenance via recombination (GO:0000722)2.52345696
165DNA replication-independent nucleosome organization (GO:0034724)2.51137901
166DNA replication-independent nucleosome assembly (GO:0006336)2.51137901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.46901364
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.75084739
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.70905853
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.70905853
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.70905853
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19806843
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.98241678
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73068409
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72444620
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.57250396
11MYC_22102868_ChIP-Seq_BL_Human2.49988551
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48150045
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.42984595
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32054503
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30984506
16* TP63_19390658_ChIP-ChIP_HaCaT_Human2.29569712
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28916692
18NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.28889907
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.27687575
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26244001
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.17126154
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16194231
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.15853385
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.06480451
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00884651
26AR_21909140_ChIP-Seq_LNCAP_Human1.99059875
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.98758028
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97005177
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.96994624
30* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95078809
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.93738795
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93293276
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92260237
34XRN2_22483619_ChIP-Seq_HELA_Human1.91984423
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85958084
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85252985
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82023222
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81793931
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79688945
40TTF2_22483619_ChIP-Seq_HELA_Human1.75032038
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71024522
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63920184
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.57027528
44DCP1A_22483619_ChIP-Seq_HELA_Human1.57002750
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53986940
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.52902145
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52591352
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52125158
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51606134
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50753948
51TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49586821
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49183877
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49079584
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48213712
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47167166
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47022321
57* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46575445
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44717689
59TCF7_22412390_ChIP-Seq_EML_Mouse1.43341543
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42871119
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42688610
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40449466
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.40340311
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39516248
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39468965
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39099161
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38359782
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38358941
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38111949
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38062947
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36232103
72ZNF263_19887448_ChIP-Seq_K562_Human1.32007164
73ELK1_19687146_ChIP-ChIP_HELA_Human1.31069688
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29846404
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27902978
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27603758
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26963478
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25434565
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24482505
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23322635
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23182284
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.23181322
83POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22992026
84* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22840586
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.21748075
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21286867
87* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20822283
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20730493
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20479839
90KDM5A_27292631_Chip-Seq_BREAST_Human1.19970619
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19809259
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19130282
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.18202834
94CHD1_26751641_Chip-Seq_LNCaP_Human1.17897116
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17850584
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17016350
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16868442
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15865601
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15585508
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15343957
101KDM2B_26808549_Chip-Seq_DND41_Human1.13538322
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11930978
103POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11556650
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.11108295
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10587722
106NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10478222
107NCOR1_26117541_ChIP-Seq_K562_Human1.08811100
108KDM2B_26808549_Chip-Seq_K562_Human1.08564484
109* SOX17_20123909_ChIP-Seq_XEN_Mouse1.08318164
110GABP_19822575_ChIP-Seq_HepG2_Human1.08268865
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06990777
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06258184
113TP53_22127205_ChIP-Seq_IMR90_Human1.05251724
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04967161
115NANOG_16518401_ChIP-PET_MESCs_Mouse1.03677245
116PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02822010
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02042082
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01972073
119* NANOG_16153702_ChIP-ChIP_HESCs_Human1.01384535
120CLOCK_20551151_ChIP-Seq_293T_Human1.01197691
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00854480
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00853153
123* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00756933
124BP1_19119308_ChIP-ChIP_Hs578T_Human0.96590236
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96450879
126TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96245425
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95972216
128* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95795719
129CIITA_25753668_ChIP-Seq_RAJI_Human0.95378725
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.93985794
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92615336
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92278659
133* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92227843
134TFEB_21752829_ChIP-Seq_HELA_Human0.92172413
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91718555
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.91659219
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91059140
138KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90804200
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89855891
140GABP_17652178_ChIP-ChIP_JURKAT_Human0.89661233
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85619625
142FOXP3_21729870_ChIP-Seq_TREG_Human0.84394804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.98270584
2MP0000537_abnormal_urethra_morphology3.59570819
3MP0003890_abnormal_embryonic-extraembry3.19666415
4MP0008057_abnormal_DNA_replication2.82780140
5MP0004264_abnormal_extraembryonic_tissu2.71143885
6MP0010352_gastrointestinal_tract_polyps2.70589016
7MP0003123_paternal_imprinting2.63941372
8MP0003121_genomic_imprinting2.49386120
9MP0003122_maternal_imprinting2.34182922
10MP0004957_abnormal_blastocyst_morpholog2.18416801
11MP0003941_abnormal_skin_development2.07687128
12MP0005380_embryogenesis_phenotype2.06146036
13MP0001672_abnormal_embryogenesis/_devel2.06146036
14MP0010030_abnormal_orbit_morphology2.03145622
15MP0005499_abnormal_olfactory_system1.94590874
16MP0005394_taste/olfaction_phenotype1.94590874
17MP0005076_abnormal_cell_differentiation1.93469275
18MP0002088_abnormal_embryonic_growth/wei1.93431513
19MP0003984_embryonic_growth_retardation1.92267065
20MP0004197_abnormal_fetal_growth/weight/1.89845208
21MP0002084_abnormal_developmental_patter1.88919901
22MP0004858_abnormal_nervous_system1.86994557
23MP0003077_abnormal_cell_cycle1.84820119
24MP0006292_abnormal_olfactory_placode1.84202681
25MP0001293_anophthalmia1.83172631
26MP0010094_abnormal_chromosome_stability1.82137812
27MP0003111_abnormal_nucleus_morphology1.80269259
28MP0000428_abnormal_craniofacial_morphol1.78551917
29MP0003283_abnormal_digestive_organ1.78271000
30MP0001730_embryonic_growth_arrest1.77426390
31MP0000350_abnormal_cell_proliferation1.76770120
32MP0005257_abnormal_intraocular_pressure1.75915188
33MP0002009_preneoplasia1.73053140
34MP0002086_abnormal_extraembryonic_tissu1.72620676
35MP0002085_abnormal_embryonic_tissue1.71357600
36MP0003119_abnormal_digestive_system1.69451459
37MP0000566_synostosis1.68364794
38MP0002092_abnormal_eye_morphology1.67054760
39MP0002653_abnormal_ependyma_morphology1.66254657
40MP0009703_decreased_birth_body1.61502228
41MP0001849_ear_inflammation1.55663903
42MP0003935_abnormal_craniofacial_develop1.54517542
43MP0003011_delayed_dark_adaptation1.54245232
44MP0009053_abnormal_anal_canal1.53708971
45MP0010307_abnormal_tumor_latency1.52740408
46MP0009672_abnormal_birth_weight1.52412212
47MP0002233_abnormal_nose_morphology1.50574934
48MP0000579_abnormal_nail_morphology1.50033442
49MP0001697_abnormal_embryo_size1.49812696
50MP0005623_abnormal_meninges_morphology1.49034796
51MP0001346_abnormal_lacrimal_gland1.48485809
52MP0010234_abnormal_vibrissa_follicle1.45621783
53MP0002932_abnormal_joint_morphology1.44192011
54MP0003937_abnormal_limbs/digits/tail_de1.39155095
55MP0000534_abnormal_ureter_morphology1.38930315
56MP0008961_abnormal_basal_metabolism1.38351509
57MP0009697_abnormal_copulation1.33094067
58MP0003755_abnormal_palate_morphology1.32773913
59MP0003787_abnormal_imprinting1.31870148
60MP0005248_abnormal_Harderian_gland1.31556667
61MP0002877_abnormal_melanocyte_morpholog1.27000925
62MP0008007_abnormal_cellular_replicative1.25811792
63MP0002080_prenatal_lethality1.25588422
64MP0005187_abnormal_penis_morphology1.23680620
65MP0000432_abnormal_head_morphology1.20825616
66MP0002796_impaired_skin_barrier1.18876427
67MP0000762_abnormal_tongue_morphology1.16391195
68MP0000569_abnormal_digit_pigmentation1.15404213
69MP0002697_abnormal_eye_size1.14953924
70MP0003942_abnormal_urinary_system1.12321565
71MP0000678_abnormal_parathyroid_gland1.11824088
72MP0004185_abnormal_adipocyte_glucose1.11191188
73MP0003861_abnormal_nervous_system1.11092715
74MP0001299_abnormal_eye_distance/1.09189941
75MP0008789_abnormal_olfactory_epithelium1.08854922
76MP0002254_reproductive_system_inflammat1.07266411
77MP0003385_abnormal_body_wall1.06647104
78MP0002111_abnormal_tail_morphology1.06295579
79MP0000733_abnormal_muscle_development1.03960557
80MP0002114_abnormal_axial_skeleton1.03468730
81MP0008770_decreased_survivor_rate1.03351968
82MP0003567_abnormal_fetal_cardiomyocyte1.03294563
83MP0005501_abnormal_skin_physiology1.01396993
84MP0002925_abnormal_cardiovascular_devel1.00598548
85MP0003115_abnormal_respiratory_system0.99701801
86MP0003938_abnormal_ear_development0.98894096
87MP0004133_heterotaxia0.98368380
88MP0002116_abnormal_craniofacial_bone0.98016299
89MP0001286_abnormal_eye_development0.93672445
90MP0002081_perinatal_lethality0.91200722
91MP0003566_abnormal_cell_adhesion0.91106444
92MP0002098_abnormal_vibrissa_morphology0.90533707
93MP0005367_renal/urinary_system_phenotyp0.88610724
94MP0000516_abnormal_urinary_system0.88610724
95MP0000462_abnormal_digestive_system0.88595698
96MP0003693_abnormal_embryo_hatching0.87500380
97MP0003718_maternal_effect0.87093592
98MP0005391_vision/eye_phenotype0.85367123
99MP0002127_abnormal_cardiovascular_syste0.83966280
100MP0000049_abnormal_middle_ear0.82231245
101MP0002249_abnormal_larynx_morphology0.82097962
102MP0003943_abnormal_hepatobiliary_system0.80043070
103MP0000647_abnormal_sebaceous_gland0.80025866
104MP0008932_abnormal_embryonic_tissue0.79752215
105MP0002269_muscular_atrophy0.79114123
106MP0001340_abnormal_eyelid_morphology0.78019466
107MP0000627_abnormal_mammary_gland0.76774948
108MP0000377_abnormal_hair_follicle0.75175692
109MP0009250_abnormal_appendicular_skeleto0.74380366
110MP0002938_white_spotting0.73894699
111MP0001348_abnormal_lacrimal_gland0.73647270
112MP0002396_abnormal_hematopoietic_system0.73553921
113MP0004272_abnormal_basement_membrane0.73448612
114MP0000778_abnormal_nervous_system0.72651707
115MP0000313_abnormal_cell_death0.72363219
116MP0000467_abnormal_esophagus_morphology0.72266456
117MP0005508_abnormal_skeleton_morphology0.71997800
118MP0000266_abnormal_heart_morphology0.71952419
119MP0002234_abnormal_pharynx_morphology0.71763581
120MP0003091_abnormal_cell_migration0.69617403
121MP0003252_abnormal_bile_duct0.69168213
122MP0004808_abnormal_hematopoietic_stem0.68089595
123MP0002970_abnormal_white_adipose0.67898987
124MP0004233_abnormal_muscle_weight0.67532499
125MP0003315_abnormal_perineum_morphology0.67439077
126MP0008058_abnormal_DNA_repair0.66437667
127MP0010678_abnormal_skin_adnexa0.65664335

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)4.47733653
2Abnormality of the lower motor neuron (HP:0002366)4.27945971
3Hepatoblastoma (HP:0002884)4.25451192
4Ependymoma (HP:0002888)3.96112509
5Renal duplication (HP:0000075)3.91319638
6Bilateral microphthalmos (HP:0007633)3.61427175
7Chromsome breakage (HP:0040012)3.50992579
8Abnormality of the astrocytes (HP:0100707)3.48207421
9Astrocytoma (HP:0009592)3.48207421
10Neoplasm of striated muscle (HP:0009728)2.98182752
11Multiple enchondromatosis (HP:0005701)2.96120091
12Rhabdomyosarcoma (HP:0002859)2.88279213
13Increased nuchal translucency (HP:0010880)2.86382469
14Rib fusion (HP:0000902)2.76714450
15Hyperacusis (HP:0010780)2.73590309
16Renovascular hypertension (HP:0100817)2.67454740
17Glioma (HP:0009733)2.64123725
18Amyotrophic lateral sclerosis (HP:0007354)2.62164743
19Short 4th metacarpal (HP:0010044)2.53794864
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53794864
21Volvulus (HP:0002580)2.53777712
22Missing ribs (HP:0000921)2.49553615
23Asymmetry of the thorax (HP:0001555)2.49160509
24Birth length less than 3rd percentile (HP:0003561)2.48025397
25Elfin facies (HP:0004428)2.44153647
26Hypopigmentation of the fundus (HP:0007894)2.42708414
27Deep philtrum (HP:0002002)2.40740674
28Pseudobulbar signs (HP:0002200)2.40142111
29High anterior hairline (HP:0009890)2.39041745
30Selective tooth agenesis (HP:0001592)2.35298308
31Ankyloglossia (HP:0010296)2.29728434
32Macroorchidism (HP:0000053)2.29571920
33Urethral obstruction (HP:0000796)2.28254573
34Overriding aorta (HP:0002623)2.23727604
35Subacute progressive viral hepatitis (HP:0006572)2.21393046
36Heterotopia (HP:0002282)2.17671030
37Abnormality of the 4th metacarpal (HP:0010012)2.17362913
38Medulloblastoma (HP:0002885)2.14763517
39Nephroblastoma (Wilms tumor) (HP:0002667)2.13371655
40Short humerus (HP:0005792)2.13327015
41Abnormality of chromosome segregation (HP:0002916)2.12080296
42Shawl scrotum (HP:0000049)2.12040782
43Lymphangioma (HP:0100764)2.11835980
44Colon cancer (HP:0003003)2.10923088
45Hyperinsulinemic hypoglycemia (HP:0000825)2.08812771
46Neoplasm of the heart (HP:0100544)2.07522121
47Impulsivity (HP:0100710)2.06412408
48Papillary thyroid carcinoma (HP:0002895)2.05559736
49Resting tremor (HP:0002322)2.03917607
50Bowel diverticulosis (HP:0005222)2.01860724
51Insomnia (HP:0100785)2.01572026
52Large earlobe (HP:0009748)2.00735177
53Absent radius (HP:0003974)2.00414844
54Embryonal renal neoplasm (HP:0011794)1.99700288
55Skin tags (HP:0010609)1.99596544
56Upper motor neuron abnormality (HP:0002127)1.98820821
57Preauricular skin tag (HP:0000384)1.98182767
58Aplasia/hypoplasia of the humerus (HP:0006507)1.97900013
59Abnormality of the diencephalon (HP:0010662)1.97858768
60Cortical dysplasia (HP:0002539)1.96716767
61Abnormality of the distal phalanx of the thumb (HP:0009617)1.96442895
62Bifid tongue (HP:0010297)1.96094132
63Overlapping toe (HP:0001845)1.92277524
64Abnormal cartilage morphology (HP:0002763)1.92209784
65Septate vagina (HP:0001153)1.91924764
66Gastrointestinal carcinoma (HP:0002672)1.91880655
67Malignant gastrointestinal tract tumors (HP:0006749)1.91880655
68Shallow orbits (HP:0000586)1.91654890
69Broad thumb (HP:0011304)1.90695868
70Hand muscle atrophy (HP:0009130)1.90431168
71Abnormality of chromosome stability (HP:0003220)1.90017747
72Facial cleft (HP:0002006)1.89609468
73Aplasia/Hypoplasia of the sternum (HP:0006714)1.88291764
74Ectopic kidney (HP:0000086)1.87992098
75Abnormal number of incisors (HP:0011064)1.87815551
76Anal stenosis (HP:0002025)1.86547220
77Long eyelashes (HP:0000527)1.86331913
78Absent forearm bone (HP:0003953)1.83174647
79Aplasia involving forearm bones (HP:0009822)1.83174647
80Abnormality of the preputium (HP:0100587)1.83116501
81Fused cervical vertebrae (HP:0002949)1.83079883
82Abnormality of the carotid arteries (HP:0005344)1.82996164
83Broad palm (HP:0001169)1.81827839
84Insidious onset (HP:0003587)1.81714495
85Termporal pattern (HP:0011008)1.81714495
86Neoplasm of the oral cavity (HP:0100649)1.80821885
87Short 5th finger (HP:0009237)1.80524697
88Mitral valve prolapse (HP:0001634)1.79522130
89Progressive external ophthalmoplegia (HP:0000590)1.78676012
90Fibroma (HP:0010614)1.78456858
91Transitional cell carcinoma of the bladder (HP:0006740)1.77708302
92Atresia of the external auditory canal (HP:0000413)1.76575532
93Fibrous tissue neoplasm (HP:0012316)1.75877043
94Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75808013
95Progressive muscle weakness (HP:0003323)1.75598923
96Squamous cell carcinoma (HP:0002860)1.75352371
97Difficulty running (HP:0009046)1.74782777
98Abnormality of the ileum (HP:0001549)1.73863468
99Absent frontal sinuses (HP:0002688)1.73101855
100Cerebral aneurysm (HP:0004944)1.72880753
101Tetraplegia (HP:0002445)1.72808472
102Sandal gap (HP:0001852)1.72608930
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.72304413
104Glossoptosis (HP:0000162)1.71910743
105Protrusio acetabuli (HP:0003179)1.71749580
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71524029
107Hallux valgus (HP:0001822)1.71148464
108Achilles tendon contracture (HP:0001771)1.71075736
109Deviation of the thumb (HP:0009603)1.70973231
110Abnormality of oral frenula (HP:0000190)1.70745813
111Angiofibromas (HP:0010615)1.70688229
112Adenoma sebaceum (HP:0009720)1.70688229
113Esophageal atresia (HP:0002032)1.70538689
114Malignant neoplasm of the central nervous system (HP:0100836)1.69939254
115Poikiloderma (HP:0001029)1.69668410
116Bladder diverticulum (HP:0000015)1.69509989
117Meckel diverticulum (HP:0002245)1.69180411
118Spastic diplegia (HP:0001264)1.69088478
119Abnormality of the phalanges of the hallux (HP:0010057)1.68973018
120Deviation of the hallux (HP:0010051)1.68945731
121Flat cornea (HP:0007720)1.68842616
122Supernumerary ribs (HP:0005815)1.68791179
123Sparse lateral eyebrow (HP:0005338)1.68785619
124Prominent nose (HP:0000448)1.68459008
125Increased connective tissue (HP:0009025)1.68100217
126Duplication of thumb phalanx (HP:0009942)1.68072786
127Proximal placement of thumb (HP:0009623)1.67671018
128Choanal atresia (HP:0000453)1.66905868
129Abnormal lung lobation (HP:0002101)1.66780256
130Ulnar bowing (HP:0003031)1.65731396
131Obsessive-compulsive behavior (HP:0000722)1.65633796
132Upper limb amyotrophy (HP:0009129)1.65550067
133Distal upper limb amyotrophy (HP:0007149)1.65550067
134Pelvic girdle muscle weakness (HP:0003749)1.65023562
135Leiomyosarcoma (HP:0100243)1.64330943
136Uterine leiomyosarcoma (HP:0002891)1.64330943
137Trigonocephaly (HP:0000243)1.64257036
138Abnormality of the parietal bone (HP:0002696)1.64168944
139Bladder carcinoma (HP:0002862)1.63197875
140Bladder neoplasm (HP:0009725)1.63197875
141Entropion (HP:0000621)1.62377718
142Cafe-au-lait spot (HP:0000957)1.61641133
143Neoplasm of the adrenal cortex (HP:0100641)1.60026352
144Smooth philtrum (HP:0000319)1.59676043
145Radioulnar synostosis (HP:0002974)1.57932068
146Partial agenesis of the corpus callosum (HP:0001338)1.56660344
147Coronal craniosynostosis (HP:0004440)1.55850210
148Breast hypoplasia (HP:0003187)1.55786001
149Microglossia (HP:0000171)1.54684678
150Hypospadias (HP:0000047)1.53274503
151Acute myeloid leukemia (HP:0004808)1.49168636
152Omphalocele (HP:0001539)1.49075761
153Short thumb (HP:0009778)1.48734053
154Acute lymphatic leukemia (HP:0006721)1.47873463
155Skull defect (HP:0001362)1.47842694
156Renal cell carcinoma (HP:0005584)1.47482021
157Small intestinal stenosis (HP:0012848)1.47143292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.34335387
2BUB12.71498799
3TRIB32.56351714
4MAP3K102.41535412
5CDC72.39575835
6TSSK62.37555793
7SMG12.29416656
8ERN12.28008046
9PKN22.23045752
10TYRO32.21463514
11TTK2.17406413
12LATS12.11378538
13GRK52.09524688
14NEK21.99149708
15MKNK11.98534999
16GRK61.98354895
17MKNK21.97575706
18TAF11.88692375
19EEF2K1.88138389
20PDGFRA1.86605323
21LATS21.85348037
22ALK1.81650980
23PLK41.66183972
24PBK1.65543856
25SCYL21.56709803
26CSF1R1.44080930
27PRKD31.41946793
28STK101.40700215
29NEK11.39702055
30MTOR1.38018766
31RIPK11.34783632
32EIF2AK11.34392080
33PAK41.34066338
34PTK61.28906161
35ERBB41.28871699
36ICK1.21848272
37CAMK1G1.21190588
38CHEK21.20613209
39WNK11.17654376
40CHEK11.16719675
41EIF2AK31.15589665
42DDR21.12872419
43MAP2K41.12366170
44CDK71.11317132
45TTN1.07934176
46MARK11.06907130
47PLK11.05277403
48PNCK1.04295029
49CDK61.02251432
50TGFBR20.99322973
51SIK10.98132936
52MST1R0.97798165
53DYRK30.94498447
54PDK40.92507995
55PDK30.92507995
56MET0.91902994
57NTRK10.91646125
58CDK40.91036423
59STK30.88962594
60PASK0.86617729
61AKT20.85601114
62MAP3K90.85261268
63KSR10.85217403
64MAPK70.83983129
65PDGFRB0.83516129
66STK38L0.82398475
67CDK20.82041328
68GRK10.81976020
69HIPK20.80996111
70FGFR30.80748674
71RPS6KA40.79856855
72CAMK1D0.79541423
73WEE10.79026078
74RPS6KB20.77724651
75MAP3K40.77065058
76EPHA20.77033055
77CAMK40.75907690
78MELK0.75885482
79PAK60.73183470
80TRIM280.72892533
81PAK20.72732832
82ATM0.71894257
83YES10.71280112
84AURKA0.70541642
85PTK20.70479798
86ERBB20.69758982
87MAP3K80.67215096
88MARK20.66534042
89VRK20.66320064
90BRD40.65508862
91STK40.65372076
92ATR0.64384069
93BRAF0.63182334
94MATK0.63101031
95TAOK10.62629952
96CSNK1E0.61854417
97CDK80.61832892
98ACVR1B0.60195690
99CDK10.59623533
100AURKB0.59305027
101TGFBR10.58882023
102FGFR10.58719981
103IRAK30.56951455
104TNIK0.55872976
105BRSK20.54962074
106BMX0.54883364
107PLK30.54534548
108CSNK1D0.53411230
109CDK90.52746587
110BRSK10.51641858
111MOS0.51206849
112NME20.50308078
113DYRK1B0.50263722
114ERBB30.49358869
115CLK10.48915650
116ADRBK10.48053782
117EIF2AK20.47968670
118MAP3K70.47857926
119KSR20.47764625
120PAK30.46551065
121AKT30.46506107
122CDK30.46182611
123RET0.45334192
124PRKDC0.44922289
125MAPK140.43748165
126DMPK0.43706824
127RPS6KB10.42994837
128SRPK10.42466477
129GSK3A0.41696474
130NTRK20.40266601
131FGFR20.39918886
132GSK3B0.38298206
133PRKAA10.38220398
134SIK20.37687030
135NUAK10.35961256
136CASK0.34339722
137STK240.32928416
138RAF10.31682680
139CDK150.29087508
140CSNK1G10.28859215
141CDK180.28446012
142CDK11A0.27395822

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.71479943
2Vitamin B6 metabolism_Homo sapiens_hsa007502.63023133
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34577242
4RNA transport_Homo sapiens_hsa030132.17864997
5mTOR signaling pathway_Homo sapiens_hsa041502.15587173
6mRNA surveillance pathway_Homo sapiens_hsa030152.09113278
7Nitrogen metabolism_Homo sapiens_hsa009102.07859428
8Nucleotide excision repair_Homo sapiens_hsa034202.02668645
9One carbon pool by folate_Homo sapiens_hsa006702.01658069
10Base excision repair_Homo sapiens_hsa034101.84996291
11Cell cycle_Homo sapiens_hsa041101.82614520
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.69133503
13Selenocompound metabolism_Homo sapiens_hsa004501.68600611
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64322533
15Homologous recombination_Homo sapiens_hsa034401.62834794
16Basal cell carcinoma_Homo sapiens_hsa052171.55343282
17Lysine degradation_Homo sapiens_hsa003101.55226851
18MicroRNAs in cancer_Homo sapiens_hsa052061.54654810
19Hippo signaling pathway_Homo sapiens_hsa043901.48873633
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46952278
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.45764289
22Chronic myeloid leukemia_Homo sapiens_hsa052201.43615302
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42162413
24Basal transcription factors_Homo sapiens_hsa030221.39797197
25Colorectal cancer_Homo sapiens_hsa052101.39175043
26Endometrial cancer_Homo sapiens_hsa052131.35641724
27RNA polymerase_Homo sapiens_hsa030201.35513546
28Thyroid cancer_Homo sapiens_hsa052161.30570163
29Non-small cell lung cancer_Homo sapiens_hsa052231.29879696
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29815226
31Systemic lupus erythematosus_Homo sapiens_hsa053221.27696977
32Adherens junction_Homo sapiens_hsa045201.25071620
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23850323
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20630010
35Spliceosome_Homo sapiens_hsa030401.18694767
36Proteoglycans in cancer_Homo sapiens_hsa052051.17870223
37Hedgehog signaling pathway_Homo sapiens_hsa043401.15881899
38Fructose and mannose metabolism_Homo sapiens_hsa000511.15568017
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14601616
40AMPK signaling pathway_Homo sapiens_hsa041521.12382254
41Pyrimidine metabolism_Homo sapiens_hsa002401.09351392
42Glioma_Homo sapiens_hsa052141.08248923
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05374793
44Dorso-ventral axis formation_Homo sapiens_hsa043201.02340464
45Viral carcinogenesis_Homo sapiens_hsa052031.01864960
46Small cell lung cancer_Homo sapiens_hsa052221.01736008
47Oocyte meiosis_Homo sapiens_hsa041141.00821432
48Fanconi anemia pathway_Homo sapiens_hsa034601.00434914
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99287347
50Pancreatic cancer_Homo sapiens_hsa052120.99250197
51Bladder cancer_Homo sapiens_hsa052190.97903104
52DNA replication_Homo sapiens_hsa030300.96769449
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96558882
54Wnt signaling pathway_Homo sapiens_hsa043100.95754353
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94832656
56Biosynthesis of amino acids_Homo sapiens_hsa012300.91559967
57Alcoholism_Homo sapiens_hsa050340.90418732
58Focal adhesion_Homo sapiens_hsa045100.89553947
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89155859
60Insulin resistance_Homo sapiens_hsa049310.88634692
61p53 signaling pathway_Homo sapiens_hsa041150.88174211
62Steroid biosynthesis_Homo sapiens_hsa001000.84158835
63Melanoma_Homo sapiens_hsa052180.83802345
64TGF-beta signaling pathway_Homo sapiens_hsa043500.83327538
65Insulin signaling pathway_Homo sapiens_hsa049100.83178628
66Notch signaling pathway_Homo sapiens_hsa043300.82729852
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.82398980
68Renal cell carcinoma_Homo sapiens_hsa052110.81573784
69Pathways in cancer_Homo sapiens_hsa052000.81437653
70Mismatch repair_Homo sapiens_hsa034300.79929483
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77785765
72Ribosome_Homo sapiens_hsa030100.76131472
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75231426
74Galactose metabolism_Homo sapiens_hsa000520.75038176
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75021906
76HTLV-I infection_Homo sapiens_hsa051660.73856714
77ErbB signaling pathway_Homo sapiens_hsa040120.73385286
78Type II diabetes mellitus_Homo sapiens_hsa049300.73137588
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72402295
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.72392564
81Prostate cancer_Homo sapiens_hsa052150.72036693
82Tight junction_Homo sapiens_hsa045300.71456747
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70506179
84Purine metabolism_Homo sapiens_hsa002300.70002437
85Estrogen signaling pathway_Homo sapiens_hsa049150.69665448
86Choline metabolism in cancer_Homo sapiens_hsa052310.69231640
87Pyruvate metabolism_Homo sapiens_hsa006200.69043043
88Acute myeloid leukemia_Homo sapiens_hsa052210.68881774
89Glucagon signaling pathway_Homo sapiens_hsa049220.67443313
90Arginine biosynthesis_Homo sapiens_hsa002200.66675523
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66322651
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65977475
93Melanogenesis_Homo sapiens_hsa049160.62385026
94Prolactin signaling pathway_Homo sapiens_hsa049170.61943447
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59088623
96Pentose phosphate pathway_Homo sapiens_hsa000300.58557789
97RNA degradation_Homo sapiens_hsa030180.58084747
98VEGF signaling pathway_Homo sapiens_hsa043700.57121086
99Rap1 signaling pathway_Homo sapiens_hsa040150.56344265
100N-Glycan biosynthesis_Homo sapiens_hsa005100.55597159
101Carbon metabolism_Homo sapiens_hsa012000.55570703
102Tryptophan metabolism_Homo sapiens_hsa003800.53293546
103GnRH signaling pathway_Homo sapiens_hsa049120.52002838
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51840285
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51738111
106Axon guidance_Homo sapiens_hsa043600.51370326
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.51108802
108Epstein-Barr virus infection_Homo sapiens_hsa051690.49326229
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48882318
110Viral myocarditis_Homo sapiens_hsa054160.47837178
111FoxO signaling pathway_Homo sapiens_hsa040680.47593173
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.46617941
113Bile secretion_Homo sapiens_hsa049760.46362218
114Complement and coagulation cascades_Homo sapiens_hsa046100.45972834
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45081870
116Inositol phosphate metabolism_Homo sapiens_hsa005620.43583547
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43344908
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42895175
119Proteasome_Homo sapiens_hsa030500.42867168
120ECM-receptor interaction_Homo sapiens_hsa045120.41703392
121Hepatitis B_Homo sapiens_hsa051610.41254671
122Circadian rhythm_Homo sapiens_hsa047100.40265423
123Gap junction_Homo sapiens_hsa045400.34408126
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26432632

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