GTF3C6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.07920072
2viral transcription (GO:0019083)5.79321140
3ribosomal small subunit assembly (GO:0000028)5.75703956
4translational termination (GO:0006415)5.67810247
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.14939338
6maturation of SSU-rRNA (GO:0030490)5.14131789
7ribosomal large subunit biogenesis (GO:0042273)5.10793959
8cotranslational protein targeting to membrane (GO:0006613)5.09934854
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.09301075
10protein targeting to ER (GO:0045047)5.01448245
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85482901
12ATP synthesis coupled proton transport (GO:0015986)4.85482901
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.76939052
14translational elongation (GO:0006414)4.76588027
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.76310805
16termination of RNA polymerase III transcription (GO:0006386)4.76310805
17protein localization to endoplasmic reticulum (GO:0070972)4.72666274
18proteasome assembly (GO:0043248)4.56398198
19cellular protein complex disassembly (GO:0043624)4.54263558
20translational initiation (GO:0006413)4.44887956
21viral life cycle (GO:0019058)4.42618509
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.37923873
23regulation of mitochondrial translation (GO:0070129)4.26973864
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.19211180
25NADH dehydrogenase complex assembly (GO:0010257)4.19211180
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.19211180
27DNA deamination (GO:0045006)4.15591525
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11735728
29translation (GO:0006412)4.10331249
30ribonucleoprotein complex biogenesis (GO:0022613)4.09802585
31protein neddylation (GO:0045116)4.06055581
32protein complex disassembly (GO:0043241)3.94974129
337-methylguanosine mRNA capping (GO:0006370)3.89414326
34RNA capping (GO:0036260)3.89037921
357-methylguanosine RNA capping (GO:0009452)3.89037921
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84466120
37protein complex biogenesis (GO:0070271)3.81759212
38macromolecular complex disassembly (GO:0032984)3.77807184
39spliceosomal complex assembly (GO:0000245)3.74220034
40respiratory electron transport chain (GO:0022904)3.72961333
41histone exchange (GO:0043486)3.72567450
42spliceosomal snRNP assembly (GO:0000387)3.71685528
43oxidative phosphorylation (GO:0006119)3.71123847
44establishment of integrated proviral latency (GO:0075713)3.70514208
45cellular component biogenesis (GO:0044085)3.69935127
46rRNA processing (GO:0006364)3.68265056
47cytochrome complex assembly (GO:0017004)3.65815046
48GTP biosynthetic process (GO:0006183)3.64818039
49electron transport chain (GO:0022900)3.63413460
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61054161
51protein localization to mitochondrion (GO:0070585)3.59163823
52negative regulation of ligase activity (GO:0051352)3.58130525
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.58130525
54chaperone-mediated protein transport (GO:0072321)3.57120618
55establishment of protein localization to mitochondrion (GO:0072655)3.56639559
56rRNA metabolic process (GO:0016072)3.56486686
57mitochondrial respiratory chain complex assembly (GO:0033108)3.54676632
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53838102
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52639614
60positive regulation of ligase activity (GO:0051351)3.51831437
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.49115127
62DNA damage response, detection of DNA damage (GO:0042769)3.47675996
63telomere maintenance via semi-conservative replication (GO:0032201)3.47097229
64purine nucleobase biosynthetic process (GO:0009113)3.47079547
65DNA double-strand break processing (GO:0000729)3.46629139
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46543102
67DNA strand elongation involved in DNA replication (GO:0006271)3.44090274
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.42947395
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.42947395
70DNA replication-independent nucleosome assembly (GO:0006336)3.42405865
71DNA replication-independent nucleosome organization (GO:0034724)3.42405865
72CENP-A containing nucleosome assembly (GO:0034080)3.41628179
73cullin deneddylation (GO:0010388)3.41305530
74formation of translation preinitiation complex (GO:0001731)3.39978521
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39342882
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39342882
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39342882
78nuclear-transcribed mRNA catabolic process (GO:0000956)3.38948207
79histone mRNA metabolic process (GO:0008334)3.38656691
80transcription-coupled nucleotide-excision repair (GO:0006283)3.37578386
81kinetochore assembly (GO:0051382)3.36968174
82protein deneddylation (GO:0000338)3.36248468
83transcription elongation from RNA polymerase I promoter (GO:0006362)3.35382177
84kinetochore organization (GO:0051383)3.34978531
85establishment of protein localization to mitochondrial membrane (GO:0090151)3.34230768
86signal transduction involved in DNA integrity checkpoint (GO:0072401)3.33875677
87signal transduction involved in DNA damage checkpoint (GO:0072422)3.33875677
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.33772208
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.33772208
90chromatin remodeling at centromere (GO:0031055)3.33265336
91regulation of cellular amino acid metabolic process (GO:0006521)3.33253541
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32846966
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.31693463
94regulation of ubiquitin-protein transferase activity (GO:0051438)3.31625583
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31200946
96DNA strand elongation (GO:0022616)3.26117362
97UTP biosynthetic process (GO:0006228)3.25961316
98establishment of viral latency (GO:0019043)3.24709319
99mRNA catabolic process (GO:0006402)3.23975729
100ATP biosynthetic process (GO:0006754)3.23804786
101pseudouridine synthesis (GO:0001522)3.23750760
102maturation of 5.8S rRNA (GO:0000460)3.23278363
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22489813
104protein targeting to membrane (GO:0006612)3.22452567
105regulation of ligase activity (GO:0051340)3.20436163
106rRNA modification (GO:0000154)3.18687976
107inner mitochondrial membrane organization (GO:0007007)3.18418929
108transcription from RNA polymerase I promoter (GO:0006360)3.18366907
109termination of RNA polymerase I transcription (GO:0006363)3.16778935
110regulation of mitotic spindle checkpoint (GO:1903504)3.15083424
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15083424
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13355095
113DNA replication checkpoint (GO:0000076)3.13168195
114telomere maintenance via recombination (GO:0000722)3.11848418
115purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10938737
116hydrogen ion transmembrane transport (GO:1902600)3.08345952
117mitochondrial transport (GO:0006839)3.08202186
118purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.08151735
119nucleobase biosynthetic process (GO:0046112)3.07093414
120guanosine-containing compound biosynthetic process (GO:1901070)3.06884884
121transcription elongation from RNA polymerase II promoter (GO:0006368)3.05636570
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05219286
123rRNA methylation (GO:0031167)3.04691344
124RNA catabolic process (GO:0006401)3.04651426
125respiratory chain complex IV assembly (GO:0008535)3.03758050
126DNA ligation (GO:0006266)3.02969896
127protein targeting to mitochondrion (GO:0006626)3.02269848
128DNA catabolic process, exonucleolytic (GO:0000738)3.01095620
129antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99367044
130regulation of cellular amine metabolic process (GO:0033238)2.98624779
131protein-cofactor linkage (GO:0018065)2.96046120
132deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.94918621
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94373448
134ribosome assembly (GO:0042255)2.92510754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89415744
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.89259894
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75365100
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.45167327
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.30819126
6EST1_17652178_ChIP-ChIP_JURKAT_Human4.26924837
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69269425
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.54377419
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48758073
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.42839879
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42653854
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.28993806
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22445977
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13850186
15E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09516365
16MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02816930
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98816638
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95891753
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85133907
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78725437
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76512881
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70320843
23VDR_23849224_ChIP-Seq_CD4+_Human2.64920088
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63330142
25XRN2_22483619_ChIP-Seq_HELA_Human2.49440961
26ELK1_19687146_ChIP-ChIP_HELA_Human2.41345595
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28878774
28FOXP3_21729870_ChIP-Seq_TREG_Human2.28117468
29TTF2_22483619_ChIP-Seq_HELA_Human2.26888977
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16471537
31DCP1A_22483619_ChIP-Seq_HELA_Human2.15831339
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.14196633
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13735057
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96506719
35* YY1_21170310_ChIP-Seq_MESCs_Mouse1.89516736
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88676377
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88516945
38GABP_19822575_ChIP-Seq_HepG2_Human1.84657884
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82523065
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80616776
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.80374307
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77620689
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74232960
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71103107
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.67314524
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56114525
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54387708
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52771009
49MYC_18940864_ChIP-ChIP_HL60_Human1.52690519
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.46174706
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45251880
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43900910
53AR_21909140_ChIP-Seq_LNCAP_Human1.43785317
54ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.42807543
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40851235
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38083997
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37994416
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35064589
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.34023868
60ZNF274_21170338_ChIP-Seq_K562_Hela1.33430373
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28965928
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28928572
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28751273
64IRF1_19129219_ChIP-ChIP_H3396_Human1.24227578
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21320204
66IGF1R_20145208_ChIP-Seq_DFB_Human1.19793724
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.17709786
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15703291
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14130157
70KDM5A_27292631_Chip-Seq_BREAST_Human1.10471946
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09657863
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08353332
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07818468
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.06423384
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04166940
76* CIITA_25753668_ChIP-Seq_RAJI_Human1.03872058
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01324191
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00594461
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.99816077
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92154091
81POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91704438
82HTT_18923047_ChIP-ChIP_STHdh_Human0.91660711
83TP53_22573176_ChIP-Seq_HFKS_Human0.90590044
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90580422
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88336010
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88052483
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.87984915
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86881578
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85575377
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85128637
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84295655
92SPI1_23547873_ChIP-Seq_NB4_Human0.84133446
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82775405
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81951722
95FUS_26573619_Chip-Seq_HEK293_Human0.81531912
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81472508
97P300_19829295_ChIP-Seq_ESCs_Human0.80158835
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77209246
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77185856
100TFEB_21752829_ChIP-Seq_HELA_Human0.76580709
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76181285
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76014900
103SOX2_16153702_ChIP-ChIP_HESCs_Human0.75596592
104AR_20517297_ChIP-Seq_VCAP_Human0.75538983
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75414184
106EZH2_27294783_Chip-Seq_NPCs_Mouse0.72427179
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.71967717
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70181720
109EWS_26573619_Chip-Seq_HEK293_Human0.69968472
110SOX2_19829295_ChIP-Seq_ESCs_Human0.69362216
111NANOG_19829295_ChIP-Seq_ESCs_Human0.69362216
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69264139
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68122455
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.66668235
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66328391
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64960440
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.61671169
118ELF5_23300383_ChIP-Seq_T47D_Human0.60885214
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.60202304
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.58292441
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.56014692
122VDR_22108803_ChIP-Seq_LS180_Human0.55337949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.43103911
2MP0003693_abnormal_embryo_hatching3.83450225
3MP0008057_abnormal_DNA_replication3.57965482
4MP0004957_abnormal_blastocyst_morpholog3.37088541
5MP0010094_abnormal_chromosome_stability2.96121658
6MP0001529_abnormal_vocalization2.79722648
7MP0003077_abnormal_cell_cycle2.75185690
8MP0008932_abnormal_embryonic_tissue2.73021781
9MP0008058_abnormal_DNA_repair2.64333978
10MP0003136_yellow_coat_color2.59184780
11MP0003111_abnormal_nucleus_morphology2.52297511
12MP0002837_dystrophic_cardiac_calcinosis2.37363298
13MP0000566_synostosis2.30081355
14MP0006292_abnormal_olfactory_placode2.20037560
15MP0002163_abnormal_gland_morphology1.95837778
16MP0005084_abnormal_gallbladder_morpholo1.95108436
17MP0004147_increased_porphyrin_level1.94453141
18MP0002938_white_spotting1.92485037
19MP0008007_abnormal_cellular_replicative1.81425443
20MP0003718_maternal_effect1.79639505
21MP0001905_abnormal_dopamine_level1.79299179
22MP0003315_abnormal_perineum_morphology1.77367021
23MP0009697_abnormal_copulation1.73980997
24MP0000049_abnormal_middle_ear1.73329540
25MP0005409_darkened_coat_color1.70255835
26MP0002132_abnormal_respiratory_system1.69470404
27MP0010030_abnormal_orbit_morphology1.68120467
28MP0002102_abnormal_ear_morphology1.58651205
29MP0003186_abnormal_redox_activity1.58102667
30MP0004215_abnormal_myocardial_fiber1.53910462
31MP0003941_abnormal_skin_development1.53068898
32MP0001188_hyperpigmentation1.52832790
33MP0002736_abnormal_nociception_after1.52518880
34MP0003123_paternal_imprinting1.46215713
35MP0002396_abnormal_hematopoietic_system1.45384775
36MP0003806_abnormal_nucleotide_metabolis1.45349671
37MP0003786_premature_aging1.39881503
38MP0008877_abnormal_DNA_methylation1.38605225
39MP0003567_abnormal_fetal_cardiomyocyte1.38012565
40MP0003937_abnormal_limbs/digits/tail_de1.35856787
41MP0003121_genomic_imprinting1.33373715
42MP0003890_abnormal_embryonic-extraembry1.28741459
43MP0003938_abnormal_ear_development1.28462390
44MP0000015_abnormal_ear_pigmentation1.27153968
45MP0001346_abnormal_lacrimal_gland1.26492864
46MP0001730_embryonic_growth_arrest1.24037821
47MP0005451_abnormal_body_composition1.23552964
48MP0008872_abnormal_physiological_respon1.22808706
49MP0006276_abnormal_autonomic_nervous1.21156914
50MP0009333_abnormal_splenocyte_physiolog1.21043846
51MP0006036_abnormal_mitochondrial_physio1.20531386
52MP0001764_abnormal_homeostasis1.20399040
53MP0000358_abnormal_cell_content/1.20254009
54MP0001984_abnormal_olfaction1.19958724
55MP0005253_abnormal_eye_physiology1.19771579
56MP0002751_abnormal_autonomic_nervous1.17737715
57MP0001293_anophthalmia1.17195027
58MP0004145_abnormal_muscle_electrophysio1.17185362
59MP0008995_early_reproductive_senescence1.16621065
60MP0002277_abnormal_respiratory_mucosa1.16214726
61MP0001485_abnormal_pinna_reflex1.15941209
62MP0002090_abnormal_vision1.15703689
63MP0001986_abnormal_taste_sensitivity1.14394076
64MP0000350_abnormal_cell_proliferation1.13631718
65MP0003195_calcinosis1.13069864
66MP0003950_abnormal_plasma_membrane1.10489125
67MP0008789_abnormal_olfactory_epithelium1.09448898
68MP0005394_taste/olfaction_phenotype1.08701809
69MP0005499_abnormal_olfactory_system1.08701809
70MP0000372_irregular_coat_pigmentation1.07906291
71MP0002095_abnormal_skin_pigmentation1.06700066
72MP0005379_endocrine/exocrine_gland_phen1.06479824
73MP0000537_abnormal_urethra_morphology1.06250948
74MP0000762_abnormal_tongue_morphology1.04859359
75MP0005174_abnormal_tail_pigmentation1.02318291
76MP0005551_abnormal_eye_electrophysiolog1.01730429
77MP0004381_abnormal_hair_follicle1.00700728
78MP0003122_maternal_imprinting1.00000313
79MP0006035_abnormal_mitochondrial_morpho0.99983203
80MP0009250_abnormal_appendicular_skeleto0.99128071
81MP0005408_hypopigmentation0.98850353
82MP0002233_abnormal_nose_morphology0.97677177
83MP0001697_abnormal_embryo_size0.96205469
84MP0003646_muscle_fatigue0.94725326
85MP0001727_abnormal_embryo_implantation0.93991252
86MP0004142_abnormal_muscle_tone0.92568034
87MP0002177_abnormal_outer_ear0.92496911
88MP0002234_abnormal_pharynx_morphology0.91504251
89MP0002148_abnormal_hypersensitivity_rea0.91197445
90MP0001929_abnormal_gametogenesis0.90985676
91MP0000490_abnormal_crypts_of0.90796252
92MP0002160_abnormal_reproductive_system0.89460650
93MP0000313_abnormal_cell_death0.89080814
94MP0003763_abnormal_thymus_physiology0.88887436
95MP0003221_abnormal_cardiomyocyte_apopto0.85306699
96MP0000653_abnormal_sex_gland0.84870275
97MP0005332_abnormal_amino_acid0.84221197
98MP0001286_abnormal_eye_development0.84163954
99MP0005410_abnormal_fertilization0.84151560
100MP0003011_delayed_dark_adaptation0.83788178
101MP0000631_abnormal_neuroendocrine_gland0.83107146
102MP0002009_preneoplasia0.82990196
103MP0004133_heterotaxia0.81451421
104MP0005636_abnormal_mineral_homeostasis0.79849056
105MP0002085_abnormal_embryonic_tissue0.78860071
106MP0001119_abnormal_female_reproductive0.78541305
107MP0003755_abnormal_palate_morphology0.76937965
108MP0005389_reproductive_system_phenotype0.76179924
109MP0005646_abnormal_pituitary_gland0.75949616
110MP0001968_abnormal_touch/_nociception0.75222970
111MP0002282_abnormal_trachea_morphology0.74284392
112MP0005645_abnormal_hypothalamus_physiol0.73899945
113MP0002210_abnormal_sex_determination0.73875981
114MP0002111_abnormal_tail_morphology0.72867952
115MP0002080_prenatal_lethality0.71659948
116MP0002638_abnormal_pupillary_reflex0.71463521
117MP0006072_abnormal_retinal_apoptosis0.71283933
118MP0005380_embryogenesis_phenotype0.70334958
119MP0001672_abnormal_embryogenesis/_devel0.70334958
120MP0002127_abnormal_cardiovascular_syste0.69129814
121MP0003787_abnormal_imprinting0.68789507
122MP0009053_abnormal_anal_canal0.67836949
123MP0002019_abnormal_tumor_incidence0.67496143
124MP0002249_abnormal_larynx_morphology0.67265045
125MP0000613_abnormal_salivary_gland0.66517977
126MP0005075_abnormal_melanosome_morpholog0.66492206
127MP0003880_abnormal_central_pattern0.65868931
128MP0003137_abnormal_impulse_conducting0.65751072
129MP0000920_abnormal_myelination0.65025991
130MP0005391_vision/eye_phenotype0.64660836
131MP0005266_abnormal_metabolism0.63461515
132MP0003984_embryonic_growth_retardation0.62784607
133MP0006054_spinal_hemorrhage0.60548747
134MP0001145_abnormal_male_reproductive0.59770183
135MP0002088_abnormal_embryonic_growth/wei0.58570169
136MP0008875_abnormal_xenobiotic_pharmacok0.58524902
137MP0002254_reproductive_system_inflammat0.58208812
138MP0000703_abnormal_thymus_morphology0.57795854
139MP0005671_abnormal_response_to0.55416577

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.60620018
2Mitochondrial inheritance (HP:0001427)5.10174661
3Abnormal mitochondria in muscle tissue (HP:0008316)4.90184708
4Reticulocytopenia (HP:0001896)4.79296308
5Increased hepatocellular lipid droplets (HP:0006565)4.79209757
6Abnormality of cells of the erythroid lineage (HP:0012130)4.60862145
7Progressive macrocephaly (HP:0004481)4.59067052
8Increased CSF lactate (HP:0002490)4.45831063
9Hepatocellular necrosis (HP:0001404)4.39042770
10Increased serum pyruvate (HP:0003542)4.34559830
11Abnormality of glycolysis (HP:0004366)4.34559830
12Acute encephalopathy (HP:0006846)4.34248666
13Abnormal number of erythroid precursors (HP:0012131)4.17866845
14Lipid accumulation in hepatocytes (HP:0006561)4.14634606
15Renal Fanconi syndrome (HP:0001994)4.12728877
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.03976696
17Macrocytic anemia (HP:0001972)3.80936032
18Exertional dyspnea (HP:0002875)3.68080352
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.64308288
20Hepatic necrosis (HP:0002605)3.64117532
213-Methylglutaconic aciduria (HP:0003535)3.34071933
22Cerebral hypomyelination (HP:0006808)3.29914351
23Increased serum lactate (HP:0002151)3.18931750
24Exercise intolerance (HP:0003546)3.15319127
25Increased intramyocellular lipid droplets (HP:0012240)3.14785035
26Birth length less than 3rd percentile (HP:0003561)3.06205960
27Pallor (HP:0000980)3.01894511
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.01652445
29Respiratory failure (HP:0002878)3.00724945
30Respiratory difficulties (HP:0002880)2.94594550
31Leukodystrophy (HP:0002415)2.94045644
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89812695
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.83210714
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.83210714
35Breast hypoplasia (HP:0003187)2.79576848
36Methylmalonic acidemia (HP:0002912)2.77037039
37Stenosis of the external auditory canal (HP:0000402)2.76668280
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74264070
39Abnormality of alanine metabolism (HP:0010916)2.74264070
40Hyperalaninemia (HP:0003348)2.74264070
41Parakeratosis (HP:0001036)2.72013721
42Cerebral edema (HP:0002181)2.66220663
43Optic disc pallor (HP:0000543)2.62080936
44Lethargy (HP:0001254)2.61141469
45Oral leukoplakia (HP:0002745)2.57876979
46Aplastic anemia (HP:0001915)2.55381119
47Lactic acidosis (HP:0003128)2.54545552
48Aplasia/hypoplasia of the uterus (HP:0008684)2.53009241
49Colon cancer (HP:0003003)2.50827693
50Abnormality of the labia minora (HP:0012880)2.47366804
51Increased muscle lipid content (HP:0009058)2.47204371
52Abnormality of renal resorption (HP:0011038)2.45900834
53Hyperglycinemia (HP:0002154)2.45842513
54Abnormality of serum amino acid levels (HP:0003112)2.41269475
55Methylmalonic aciduria (HP:0012120)2.40206532
56Abnormality of the anterior horn cell (HP:0006802)2.39002254
57Degeneration of anterior horn cells (HP:0002398)2.39002254
58Microvesicular hepatic steatosis (HP:0001414)2.35254707
59Patellar aplasia (HP:0006443)2.30586559
60Rough bone trabeculation (HP:0100670)2.27998505
61Amniotic constriction ring (HP:0009775)2.20442431
62Abnormality of placental membranes (HP:0011409)2.20442431
63Aplasia/Hypoplasia of the patella (HP:0006498)2.19783954
64Triphalangeal thumb (HP:0001199)2.19218479
65Congenital ichthyosiform erythroderma (HP:0007431)2.18228579
66Abnormal protein glycosylation (HP:0012346)2.11853319
67Abnormal glycosylation (HP:0012345)2.11853319
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11853319
69Abnormal protein N-linked glycosylation (HP:0012347)2.11853319
70Concave nail (HP:0001598)2.11260877
71Abnormal hemoglobin (HP:0011902)2.10292498
72Hypoplasia of the uterus (HP:0000013)2.09809308
73Pancreatic fibrosis (HP:0100732)2.09675522
74Glycosuria (HP:0003076)2.08432412
75Abnormality of urine glucose concentration (HP:0011016)2.08432412
76Pancreatic cysts (HP:0001737)2.08116465
77Abnormality of methionine metabolism (HP:0010901)2.07082027
78Horseshoe kidney (HP:0000085)2.04450986
79Secondary amenorrhea (HP:0000869)2.04128853
80Abnormality of the preputium (HP:0100587)2.02320930
81Abnormality of midbrain morphology (HP:0002418)2.02291241
82Molar tooth sign on MRI (HP:0002419)2.02291241
83Reduced antithrombin III activity (HP:0001976)2.02051279
84Generalized aminoaciduria (HP:0002909)2.01996803
85Partial duplication of thumb phalanx (HP:0009944)2.00724680
86Carpal bone hypoplasia (HP:0001498)1.99696986
87Type I transferrin isoform profile (HP:0003642)1.99318948
88CNS demyelination (HP:0007305)1.98981569
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96950986
90Hypoplasia of the radius (HP:0002984)1.95593386
91Absent radius (HP:0003974)1.94589966
92Premature graying of hair (HP:0002216)1.93589037
93Chromsome breakage (HP:0040012)1.93398730
94Duplication of thumb phalanx (HP:0009942)1.92829117
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.92705112
96True hermaphroditism (HP:0010459)1.91136852
97Partial duplication of the phalanx of hand (HP:0009999)1.90815763
98Multiple enchondromatosis (HP:0005701)1.90246030
99Absent thumb (HP:0009777)1.89191775
100Duplicated collecting system (HP:0000081)1.88016592
101Abnormal trabecular bone morphology (HP:0100671)1.87997907
102Hyperglycinuria (HP:0003108)1.85814224
103Aplasia involving forearm bones (HP:0009822)1.85170235
104Absent forearm bone (HP:0003953)1.85170235
105Abnormality of chromosome stability (HP:0003220)1.84985576
10611 pairs of ribs (HP:0000878)1.84593725
107Glossoptosis (HP:0000162)1.84232845
108Megaloblastic anemia (HP:0001889)1.82988231
109Abnormality of the septum pellucidum (HP:0007375)1.82194296
110Abnormal lung lobation (HP:0002101)1.81619555
111Septo-optic dysplasia (HP:0100842)1.81060090
112Abnormality of glycine metabolism (HP:0010895)1.80785525
113Abnormality of serine family amino acid metabolism (HP:0010894)1.80785525
114Emotional lability (HP:0000712)1.80415805
115Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78891374
116Pancytopenia (HP:0001876)1.78579738
117Muscle fiber atrophy (HP:0100295)1.77974007
118Medial flaring of the eyebrow (HP:0010747)1.77638568
119CNS hypomyelination (HP:0003429)1.76892357
120Absent septum pellucidum (HP:0001331)1.76559176
121Dicarboxylic aciduria (HP:0003215)1.76555208
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76555208
123Congenital, generalized hypertrichosis (HP:0004540)1.75809046
124Neoplasm of the adrenal gland (HP:0100631)1.74619360
125Adrenal hypoplasia (HP:0000835)1.74508553
126X-linked dominant inheritance (HP:0001423)1.74298594
127Blindness (HP:0000618)1.73868407
128Meckel diverticulum (HP:0002245)1.73225716
129Sclerocornea (HP:0000647)1.72909389
130Abnormality of secondary sexual hair (HP:0009888)1.71513677
131Abnormality of the axillary hair (HP:0100134)1.71513677
132Nausea (HP:0002018)1.70389542
133Depressed nasal ridge (HP:0000457)1.69509388
134Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69125248
135Asplenia (HP:0001746)1.68586141
136Cleft eyelid (HP:0000625)1.68171085
137Type 2 muscle fiber atrophy (HP:0003554)1.66879241
138Abnormality of the renal collecting system (HP:0004742)1.65068604
139Abnormality of the ileum (HP:0001549)1.64244242
140Sparse eyelashes (HP:0000653)1.63713370
141Testicular atrophy (HP:0000029)1.63177965
142Palpitations (HP:0001962)1.62919332
143Split foot (HP:0001839)1.62754308
144Abnormal number of incisors (HP:0011064)1.62124034
145Hyperphosphaturia (HP:0003109)1.61491742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.21509937
2BUB14.00684708
3VRK23.78413326
4SRPK12.91757838
5WEE12.84530449
6TLK12.82969430
7EIF2AK12.76311318
8NME22.68369530
9MST42.61297201
10NEK12.54129434
11TESK22.52650855
12MKNK12.47241428
13VRK12.13480061
14TRIM282.02030558
15PBK1.99107676
16BRSK21.98772711
17MAP4K21.92860435
18EIF2AK31.90929111
19BCR1.84572304
20NME11.79719488
21STK391.78817588
22CDC71.76729544
23PLK41.71744729
24BCKDK1.70997323
25TSSK61.60265803
26MKNK21.58293642
27PIM21.56515765
28LIMK11.48832778
29NUAK11.42865571
30PDK21.40599642
31DYRK21.35856080
32PLK11.27637296
33BMPR1B1.24252039
34AURKB1.20255649
35PLK31.19702948
36CDK81.16934078
37GRK11.14375463
38CASK1.11154891
39MAPKAPK51.07450450
40OXSR11.04663882
41CDK71.03988031
42DYRK31.03506937
43ACVR1B1.03465060
44EIF2AK20.98894059
45TTK0.97493461
46AURKA0.96010691
47CSNK1G20.94805153
48CLK10.93915673
49MYLK0.93796303
50TAF10.91832758
51MAP3K120.87767062
52ATR0.86724848
53BRSK10.86560331
54ILK0.85532465
55STK38L0.84882627
56CSNK2A10.82733240
57CDK190.82665073
58CHEK20.79419002
59SCYL20.79394209
60ADRBK20.78955950
61ABL20.78517148
62RPS6KA50.76475681
63ZAK0.76042077
64CSNK2A20.75236885
65PNCK0.74673804
66OBSCN0.73626170
67RPS6KA40.73294674
68CSNK1G30.72659646
69TEC0.72335564
70RPS6KB20.72160205
71TXK0.71759947
72TNIK0.70785474
73CCNB10.70175453
74YES10.69671234
75KDR0.69095848
76STK100.67458102
77PAK10.66159888
78MAP2K70.65957553
79DAPK10.65521715
80BLK0.59812871
81GRK70.57815455
82CHEK10.56891922
83PLK20.55776031
84MAP3K40.53294287
85PASK0.52099054
86ERBB30.50532060
87BRAF0.49573991
88TESK10.49558302
89NEK20.48845718
90WNK40.48234057
91UHMK10.48190835
92INSRR0.47832095
93ROCK20.47544401
94IRAK40.45306123
95CSNK1G10.44880712
96STK40.44390562
97CSNK1E0.43947123
98NEK60.43668708
99MINK10.43168038
100ATM0.42402743
101ALK0.41746469
102DAPK30.39316144
103STK30.38972607
104ADRBK10.37989856
105PKN10.37427929
106CDK30.37119373
107PIK3CG0.36857118
108PAK40.36854525
109BMPR20.36757955
110MAP3K50.36534511
111LYN0.36091755
112PRKCG0.35996524
113CDK10.35802277
114TIE10.35540532
115CDK20.35421200
116TGFBR10.35338396
117LRRK20.35318005
118IKBKB0.34282784
119WNK30.34232654
120PINK10.34047927
121FRK0.33115791
122CSNK1A10.33113704
123EPHB20.32540055
124MUSK0.31405471
125CDK140.30301777
126MAPK130.29414925
127CSNK1A1L0.28764930

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.22486401
2Proteasome_Homo sapiens_hsa030504.24066925
3RNA polymerase_Homo sapiens_hsa030204.23456184
4Oxidative phosphorylation_Homo sapiens_hsa001903.50842253
5DNA replication_Homo sapiens_hsa030303.25851751
6Parkinsons disease_Homo sapiens_hsa050123.15285468
7Mismatch repair_Homo sapiens_hsa034303.05306303
8Spliceosome_Homo sapiens_hsa030403.00916601
9Protein export_Homo sapiens_hsa030602.90187377
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67182690
11Homologous recombination_Homo sapiens_hsa034402.44890006
12Pyrimidine metabolism_Homo sapiens_hsa002402.42167756
13Huntingtons disease_Homo sapiens_hsa050162.39476885
14Nucleotide excision repair_Homo sapiens_hsa034202.30549463
15Alzheimers disease_Homo sapiens_hsa050102.09696557
16Basal transcription factors_Homo sapiens_hsa030222.06710699
17RNA transport_Homo sapiens_hsa030132.03961339
18Base excision repair_Homo sapiens_hsa034102.01732436
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88012836
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.84296778
21Non-homologous end-joining_Homo sapiens_hsa034501.77876845
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64902781
23Fanconi anemia pathway_Homo sapiens_hsa034601.57073380
24Cell cycle_Homo sapiens_hsa041101.56905312
25Propanoate metabolism_Homo sapiens_hsa006401.50580185
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49889156
27RNA degradation_Homo sapiens_hsa030181.49766441
28Purine metabolism_Homo sapiens_hsa002301.42138449
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34123281
30One carbon pool by folate_Homo sapiens_hsa006701.32416491
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29107414
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21547047
33Steroid biosynthesis_Homo sapiens_hsa001001.19574468
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13654222
35Fatty acid elongation_Homo sapiens_hsa000621.11711259
36mRNA surveillance pathway_Homo sapiens_hsa030151.07459733
37Cardiac muscle contraction_Homo sapiens_hsa042601.06401213
38Epstein-Barr virus infection_Homo sapiens_hsa051690.97636632
39Arachidonic acid metabolism_Homo sapiens_hsa005900.84183185
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83980952
41Peroxisome_Homo sapiens_hsa041460.82732040
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80128831
43Ether lipid metabolism_Homo sapiens_hsa005650.76081970
44Collecting duct acid secretion_Homo sapiens_hsa049660.75388406
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74696044
46Glutathione metabolism_Homo sapiens_hsa004800.74390937
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73166507
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71083887
49Butanoate metabolism_Homo sapiens_hsa006500.70461629
50Folate biosynthesis_Homo sapiens_hsa007900.70449523
51p53 signaling pathway_Homo sapiens_hsa041150.65609457
52Allograft rejection_Homo sapiens_hsa053300.63317154
53Selenocompound metabolism_Homo sapiens_hsa004500.62411260
54Metabolic pathways_Homo sapiens_hsa011000.61948971
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61014370
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57786124
57Vitamin B6 metabolism_Homo sapiens_hsa007500.57566565
58Linoleic acid metabolism_Homo sapiens_hsa005910.57477412
59Systemic lupus erythematosus_Homo sapiens_hsa053220.57193306
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.54186723
61Primary immunodeficiency_Homo sapiens_hsa053400.50986887
62Fatty acid degradation_Homo sapiens_hsa000710.50309604
63Autoimmune thyroid disease_Homo sapiens_hsa053200.49741385
64Nitrogen metabolism_Homo sapiens_hsa009100.49328469
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48980292
66Tryptophan metabolism_Homo sapiens_hsa003800.47682181
67Graft-versus-host disease_Homo sapiens_hsa053320.47664193
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.46690574
69beta-Alanine metabolism_Homo sapiens_hsa004100.46258555
70Fatty acid metabolism_Homo sapiens_hsa012120.45514950
71Asthma_Homo sapiens_hsa053100.44763104
72Chemical carcinogenesis_Homo sapiens_hsa052040.44065317
73Sphingolipid metabolism_Homo sapiens_hsa006000.43046894
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.42008120
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.41829206
76Sulfur relay system_Homo sapiens_hsa041220.41731548
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40635589
78Antigen processing and presentation_Homo sapiens_hsa046120.40539150
79Herpes simplex infection_Homo sapiens_hsa051680.39241877
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38792646
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37730224
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36048917
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32739919
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32384826
85Caffeine metabolism_Homo sapiens_hsa002320.32219019
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32137769
87Rheumatoid arthritis_Homo sapiens_hsa053230.29811252
88Fat digestion and absorption_Homo sapiens_hsa049750.28966422
89Oocyte meiosis_Homo sapiens_hsa041140.28910412
90Vitamin digestion and absorption_Homo sapiens_hsa049770.28109053
91Retinol metabolism_Homo sapiens_hsa008300.27544130
92N-Glycan biosynthesis_Homo sapiens_hsa005100.27378463
93Viral carcinogenesis_Homo sapiens_hsa052030.26357635
94Pentose phosphate pathway_Homo sapiens_hsa000300.25879108
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24355314
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23370315
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.23110801
98Sulfur metabolism_Homo sapiens_hsa009200.21927737
99Basal cell carcinoma_Homo sapiens_hsa052170.21233395
100Tyrosine metabolism_Homo sapiens_hsa003500.20438853
101Viral myocarditis_Homo sapiens_hsa054160.20050845
102TGF-beta signaling pathway_Homo sapiens_hsa043500.19416570
103Arginine and proline metabolism_Homo sapiens_hsa003300.18927627
104Phototransduction_Homo sapiens_hsa047440.18787193
105Hematopoietic cell lineage_Homo sapiens_hsa046400.18543553
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17798130
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17234401
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.17082550
109Pyruvate metabolism_Homo sapiens_hsa006200.17064031
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15932008
111Hedgehog signaling pathway_Homo sapiens_hsa043400.15457877
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15100677
113Alcoholism_Homo sapiens_hsa050340.14831863
114HTLV-I infection_Homo sapiens_hsa051660.14365813
115Carbon metabolism_Homo sapiens_hsa012000.13459982
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13415949
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13317130
118Other glycan degradation_Homo sapiens_hsa005110.12280520
119Vibrio cholerae infection_Homo sapiens_hsa051100.11380517
120Biosynthesis of amino acids_Homo sapiens_hsa012300.10560431
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.09801527
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09625204
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09547635
124Measles_Homo sapiens_hsa051620.09167850
125Phagosome_Homo sapiens_hsa041450.08669078
126Shigellosis_Homo sapiens_hsa051310.08367606
127Hippo signaling pathway_Homo sapiens_hsa043900.08223906
128Regulation of autophagy_Homo sapiens_hsa041400.06952482
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06524907
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.06211807

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