GTPBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.64371553
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.51220144
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51220144
4negative regulation of cell killing (GO:0031342)4.41227646
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.41227646
6regulation of gamma-delta T cell differentiation (GO:0045586)4.25402682
7negative thymic T cell selection (GO:0045060)4.06521675
8antigen processing and presentation of endogenous antigen (GO:0019883)4.03731128
9negative T cell selection (GO:0043383)4.03232456
10DNA unwinding involved in DNA replication (GO:0006268)3.96055380
11regulation of gamma-delta T cell activation (GO:0046643)3.90140729
12positive thymic T cell selection (GO:0045059)3.86633700
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86167086
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.86167086
15modulation by symbiont of host immune response (GO:0052553)3.86167086
16positive regulation by symbiont of host defense response (GO:0052509)3.86167086
17modulation by symbiont of host defense response (GO:0052031)3.86167086
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86167086
19regulation of NFAT protein import into nucleus (GO:0051532)3.79611158
20protein localization to kinetochore (GO:0034501)3.72371678
21negative regulation of histone methylation (GO:0031061)3.70621869
22detection of other organism (GO:0098543)3.70284344
23response to peptidoglycan (GO:0032494)3.69649363
24activation of MAPKKK activity (GO:0000185)3.68464055
25germinal center formation (GO:0002467)3.65047849
26detection of bacterium (GO:0016045)3.63828506
27thymic T cell selection (GO:0045061)3.52885882
28NIK/NF-kappaB signaling (GO:0038061)3.52470836
29dosage compensation (GO:0007549)3.51017142
30response to type I interferon (GO:0034340)3.46330904
31type I interferon signaling pathway (GO:0060337)3.46037248
32cellular response to type I interferon (GO:0071357)3.46037248
33pre-miRNA processing (GO:0031054)3.45815142
343-UTR-mediated mRNA stabilization (GO:0070935)3.34493203
35positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33988324
36folic acid-containing compound biosynthetic process (GO:0009396)3.29906311
37histone H3-K36 demethylation (GO:0070544)3.28751371
38antigen processing and presentation via MHC class Ib (GO:0002475)3.27033911
39cellular response to virus (GO:0098586)3.25712606
40nuclear pore complex assembly (GO:0051292)3.24702437
41mitotic nuclear envelope disassembly (GO:0007077)3.22006589
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20683675
43protein localization to chromosome, centromeric region (GO:0071459)3.19955781
44positive regulation of histone deacetylation (GO:0031065)3.16350865
45negative regulation of toll-like receptor signaling pathway (GO:0034122)3.14741731
46T cell selection (GO:0045058)3.14388219
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13290773
48positive T cell selection (GO:0043368)3.13136703
49mitotic chromosome condensation (GO:0007076)3.10115492
50nuclear pore organization (GO:0006999)3.08578368
51macrophage activation involved in immune response (GO:0002281)3.07031780
52membrane disassembly (GO:0030397)3.03593731
53nuclear envelope disassembly (GO:0051081)3.03593731
54peptidyl-lysine dimethylation (GO:0018027)3.03283464
55regulation of interleukin-12 biosynthetic process (GO:0045075)3.02955988
56response to laminar fluid shear stress (GO:0034616)3.02692254
57translesion synthesis (GO:0019985)3.02623215
58DNA duplex unwinding (GO:0032508)3.02200962
59regulation of translational fidelity (GO:0006450)3.01976374
60glucocorticoid receptor signaling pathway (GO:0042921)3.01348322
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00445390
62mannose metabolic process (GO:0006013)2.98794452
63DNA geometric change (GO:0032392)2.97039504
64detection of external biotic stimulus (GO:0098581)2.95986708
65negative regulation of RNA splicing (GO:0033119)2.95714716
66natural killer cell differentiation (GO:0001779)2.93965128
67negative regulation of interleukin-12 production (GO:0032695)2.93186056
68DNA strand elongation involved in DNA replication (GO:0006271)2.92192259
69RNA stabilization (GO:0043489)2.89785260
70mRNA stabilization (GO:0048255)2.89785260
71embryonic process involved in female pregnancy (GO:0060136)2.88665689
72regulation of histone H3-K9 methylation (GO:0051570)2.86601085
73mitotic sister chromatid cohesion (GO:0007064)2.85779948
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83256969
75corticosteroid receptor signaling pathway (GO:0031958)2.81890616
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80940147
77response to host immune response (GO:0052572)2.80940147
78nucleosome disassembly (GO:0006337)2.80695258
79protein-DNA complex disassembly (GO:0032986)2.80695258
80regulation of chromatin binding (GO:0035561)2.80263999
81detection of biotic stimulus (GO:0009595)2.79573275
82positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78436220
83regulation of interferon-beta biosynthetic process (GO:0045357)2.78177812
84tolerance induction (GO:0002507)2.77655266
85B cell receptor signaling pathway (GO:0050853)2.77477929
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76100691
87modulation by symbiont of host cellular process (GO:0044068)2.74024891
88negative regulation of erythrocyte differentiation (GO:0045647)2.73049816
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72433937
90DNA strand elongation (GO:0022616)2.72347630
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.72182479
92response to host (GO:0075136)2.71185060
93response to host defenses (GO:0052200)2.71185060
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71185060
95histone H2A monoubiquitination (GO:0035518)2.69153174
96heterochromatin organization (GO:0070828)2.68669064
97detection of molecule of bacterial origin (GO:0032490)2.66366553
98regulation of translational termination (GO:0006449)2.65481189
99NLS-bearing protein import into nucleus (GO:0006607)2.65012125
100cellular extravasation (GO:0045123)2.64477015
101T cell apoptotic process (GO:0070231)2.63676382
102regulation of necroptotic process (GO:0060544)2.63257718
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62969049
104sister chromatid segregation (GO:0000819)2.62912521
105positive regulation of interferon-alpha production (GO:0032727)2.62662013
106histone lysine demethylation (GO:0070076)2.62214458
107regulation of interferon-alpha production (GO:0032647)2.60677962
108regulation of B cell receptor signaling pathway (GO:0050855)2.60236009
109response to muramyl dipeptide (GO:0032495)2.60219848
110modulation by virus of host process (GO:0019054)2.60042823
111protein localization to endosome (GO:0036010)2.59638713
112positive regulation of protein deacetylation (GO:0090312)2.59482133
113response to interleukin-15 (GO:0070672)2.59202018
114regulation of toll-like receptor signaling pathway (GO:0034121)2.58994128
115Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58418764
116histone demethylation (GO:0016577)2.57985769
117positive regulation of type 2 immune response (GO:0002830)2.57442030
118barbed-end actin filament capping (GO:0051016)2.56553285
119negative regulation of myotube differentiation (GO:0010832)2.54396188
120negative regulation of gene expression, epigenetic (GO:0045814)2.53865876
121intracellular estrogen receptor signaling pathway (GO:0030520)2.53252233
122nuclear envelope organization (GO:0006998)2.52999440
123negative regulation of lymphocyte mediated immunity (GO:0002707)2.51742491
124regulation of T-helper 2 cell differentiation (GO:0045628)2.51730921
125negative regulation of T cell mediated immunity (GO:0002710)2.51645650
126chromatin assembly (GO:0031497)2.51589181
127negative regulation of mRNA metabolic process (GO:1903312)2.51503163
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51353938
129epithelial cell fate commitment (GO:0072148)2.51238919
130regulation of T cell tolerance induction (GO:0002664)2.50257876
131DNA replication initiation (GO:0006270)2.49879193
132negative regulation of mRNA processing (GO:0050686)2.48580622
133positive regulation of B cell differentiation (GO:0045579)2.47902115
134positive regulation of isotype switching (GO:0045830)2.44253659
135immunoglobulin mediated immune response (GO:0016064)2.43674636
136negative regulation of leukocyte mediated immunity (GO:0002704)2.42380509
137positive regulation of RNA splicing (GO:0033120)2.41881954
138alternative mRNA splicing, via spliceosome (GO:0000380)2.41078518
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.41074470
140mitotic sister chromatid segregation (GO:0000070)2.40558319
141regulation of erythrocyte differentiation (GO:0045646)2.40032437
142regulation of protein heterodimerization activity (GO:0043497)2.39976942
143negative regulation of innate immune response (GO:0045824)2.39759892
144negative regulation of viral release from host cell (GO:1902187)2.39600203
145positive regulation of Rap GTPase activity (GO:0032854)2.39563434
146DNA replication-dependent nucleosome assembly (GO:0006335)2.38919608
147DNA replication-dependent nucleosome organization (GO:0034723)2.38919608
148apoptotic process involved in morphogenesis (GO:0060561)2.37700294
149positive regulation of cellular amide metabolic process (GO:0034250)2.37438344
150B cell homeostasis (GO:0001782)2.37140612
151negative regulation of cell size (GO:0045792)2.37089552
152interferon-gamma-mediated signaling pathway (GO:0060333)2.36033844
153pore complex assembly (GO:0046931)2.35447969
154telomere maintenance via semi-conservative replication (GO:0032201)2.35390409
155interferon-gamma production (GO:0032609)2.35154559
156spliceosomal tri-snRNP complex assembly (GO:0000244)2.34940898
157T cell migration (GO:0072678)2.34528767
158erythrocyte maturation (GO:0043249)2.34518843
159gene silencing (GO:0016458)2.34496311
160positive regulation of lamellipodium assembly (GO:0010592)2.33863038
161IMP biosynthetic process (GO:0006188)2.33375826
162positive regulation of gene expression, epigenetic (GO:0045815)2.32229349
163histone H3-K4 methylation (GO:0051568)2.31735971
164defense response to protozoan (GO:0042832)2.30973789
165leukocyte aggregation (GO:0070486)2.30286274
166regulation of B cell differentiation (GO:0045577)2.30245044
167DNA conformation change (GO:0071103)2.29833700
168positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.29242401
169regulation of leukocyte degranulation (GO:0043300)2.27553780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.40610090
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.30019541
3MYC_22102868_ChIP-Seq_BL_Human4.07536151
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.94654434
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96367867
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92112855
7VDR_21846776_ChIP-Seq_THP-1_Human2.90900328
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54037379
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.47264595
10TCF7_22412390_ChIP-Seq_EML_Mouse2.30110247
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.21548972
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16323000
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.15270000
14MAF_26560356_Chip-Seq_TH1_Human2.09747335
15KDM2B_26808549_Chip-Seq_DND41_Human2.03649056
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00191004
17KDM2B_26808549_Chip-Seq_K562_Human1.97947134
18* CIITA_25753668_ChIP-Seq_RAJI_Human1.95795327
19UTX_26944678_Chip-Seq_JUKART_Human1.95310848
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92401921
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83977266
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82703932
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82473697
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.82102816
25SCL_19346495_ChIP-Seq_HPC-7_Human1.81980174
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80513835
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80144509
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.79389899
29MYB_26560356_Chip-Seq_TH2_Human1.71171920
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71134871
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.70459278
32* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69646152
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.66169229
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62833752
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.62579394
36MYB_26560356_Chip-Seq_TH1_Human1.59128817
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59113904
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58557065
39GATA1_19941826_ChIP-Seq_K562_Human1.56984075
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56397418
41VDR_24763502_ChIP-Seq_THP-1_Human1.56106394
42* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55372745
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53991461
44* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53411395
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50223099
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49529515
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49176784
48* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46556072
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.45470375
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43499756
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42787503
52* XRN2_22483619_ChIP-Seq_HELA_Human1.42319525
53* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41196015
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40956264
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39508443
56MAF_26560356_Chip-Seq_TH2_Human1.38725780
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36980582
58SMC4_20622854_ChIP-Seq_HELA_Human1.32349203
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.31675043
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30543446
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.30172146
62LXR_22292898_ChIP-Seq_THP-1_Human1.28808369
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26753318
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26739525
65CREB1_26743006_Chip-Seq_LNCaP_Human1.26376780
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23788528
67ZNF263_19887448_ChIP-Seq_K562_Human1.22183330
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22080173
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21870347
70SPI1_23547873_ChIP-Seq_NB4_Human1.21783764
71NCOR1_26117541_ChIP-Seq_K562_Human1.21561493
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21179405
73* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20893506
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20112183
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19847286
76* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19762113
77* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18992763
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18719308
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18324631
80KDM5A_27292631_Chip-Seq_BREAST_Human1.17372158
81* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17192018
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16129743
83RUNX_20019798_ChIP-Seq_JUKART_Human1.15824895
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14866322
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13009657
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12918608
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12740234
88SPI1_23127762_ChIP-Seq_K562_Human1.12637049
89CLOCK_20551151_ChIP-Seq_293T_Human1.11827832
90AR_21909140_ChIP-Seq_LNCAP_Human1.11139619
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.11121278
92GATA1_22025678_ChIP-Seq_K562_Human1.09876787
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.09784228
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08020072
95* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07503651
96* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07158799
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06934163
98BCOR_27268052_Chip-Seq_Bcells_Human1.06652238
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06461066
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06278417
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04486766
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04084850
103P68_20966046_ChIP-Seq_HELA_Human1.03371752
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03082313
105* TFEB_21752829_ChIP-Seq_HELA_Human1.01352679
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01053759
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00127632
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99340675
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98958112
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98455462
111FOXP3_21729870_ChIP-Seq_TREG_Human0.98093350
112ATF3_27146783_Chip-Seq_COLON_Human0.98060947
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97141897
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96919402
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96787492
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96467783
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.96223176
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96122330
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.95609482
120GATA3_27048872_Chip-Seq_THYMUS_Human0.95164342
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95122010
122GATA2_19941826_ChIP-Seq_K562_Human0.95032759
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.94921471
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.94143659
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93963639
126RACK7_27058665_Chip-Seq_MCF-7_Human0.93919484
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93087672
128* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93063140
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92822359
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92554856
131* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92506681
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.92384858
133* ELF1_20517297_ChIP-Seq_JURKAT_Human0.92005473
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91872252
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91574518
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91160303
137ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91141628
138SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90220802
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90018095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation2.84871163
2MP0000685_abnormal_immune_system2.83700354
3MP0002396_abnormal_hematopoietic_system2.80903903
4MP0003111_abnormal_nucleus_morphology2.74992528
5MP0003763_abnormal_thymus_physiology2.73429868
6MP0003724_increased_susceptibility_to2.69318664
7MP0010352_gastrointestinal_tract_polyps2.65763776
8MP0005451_abnormal_body_composition2.62722914
9MP0003077_abnormal_cell_cycle2.35686254
10MP0004858_abnormal_nervous_system2.34892120
11MP0008260_abnormal_autophagy2.31037189
12MP0003300_gastrointestinal_ulcer2.30231412
13MP0010094_abnormal_chromosome_stability2.29146705
14MP0004808_abnormal_hematopoietic_stem2.27962799
15MP0009278_abnormal_bone_marrow2.24608907
16MP0002398_abnormal_bone_marrow2.22717318
17MP0003693_abnormal_embryo_hatching2.20798018
18MP0010307_abnormal_tumor_latency2.17045862
19MP0000703_abnormal_thymus_morphology2.05648908
20MP0003303_peritoneal_inflammation2.05053416
21MP0001835_abnormal_antigen_presentation2.03799526
22MP0001545_abnormal_hematopoietic_system2.01801222
23MP0005397_hematopoietic_system_phenotyp2.01801222
24MP0001800_abnormal_humoral_immune1.98341992
25MP0008057_abnormal_DNA_replication1.96470403
26MP0002009_preneoplasia1.96412579
27MP0003436_decreased_susceptibility_to1.86946226
28MP0003705_abnormal_hypodermis_morpholog1.86833921
29MP0008961_abnormal_basal_metabolism1.83331488
30MP0000350_abnormal_cell_proliferation1.80888601
31MP0002722_abnormal_immune_system1.78515096
32MP0002877_abnormal_melanocyte_morpholog1.77694595
33MP0004957_abnormal_blastocyst_morpholog1.77303543
34MP0001873_stomach_inflammation1.72896102
35MP0001819_abnormal_immune_cell1.71418509
36MP0002420_abnormal_adaptive_immunity1.71308882
37MP0002166_altered_tumor_susceptibility1.68681345
38MP0005671_abnormal_response_to1.68656233
39MP0000716_abnormal_immune_system1.68204051
40MP0001730_embryonic_growth_arrest1.66519124
41MP0002452_abnormal_antigen_presenting1.65350465
42MP0001790_abnormal_immune_system1.64984860
43MP0005387_immune_system_phenotype1.64984860
44MP0000689_abnormal_spleen_morphology1.62192966
45MP0002429_abnormal_blood_cell1.59029164
46MP0006082_CNS_inflammation1.57530891
47MP0002723_abnormal_immune_serum1.57314446
48MP0010030_abnormal_orbit_morphology1.56299297
49MP0001533_abnormal_skeleton_physiology1.55642151
50MP0009333_abnormal_splenocyte_physiolog1.53300027
51MP0002405_respiratory_system_inflammati1.52111638
52MP0002254_reproductive_system_inflammat1.51506352
53MP0008007_abnormal_cellular_replicative1.49073127
54MP0002019_abnormal_tumor_incidence1.48895546
55MP0004947_skin_inflammation1.44786448
56MP0005000_abnormal_immune_tolerance1.44784346
57MP0004510_myositis1.44140597
58MP0000490_abnormal_crypts_of1.39956144
59MP0005058_abnormal_lysosome_morphology1.38933101
60MP0002653_abnormal_ependyma_morphology1.37672410
61MP0010155_abnormal_intestine_physiology1.32415998
62MP0002148_abnormal_hypersensitivity_rea1.29836199
63MP0009840_abnormal_foam_cell1.28573361
64MP0003984_embryonic_growth_retardation1.27392721
65MP0002998_abnormal_bone_remodeling1.26870405
66MP0000858_altered_metastatic_potential1.26832277
67MP0002088_abnormal_embryonic_growth/wei1.24714761
68MP0002138_abnormal_hepatobiliary_system1.24335901
69MP0002006_tumorigenesis1.23740561
70MP0002089_abnormal_postnatal_growth/wei1.22704375
71MP0000313_abnormal_cell_death1.22543078
72MP0005025_abnormal_response_to1.21907748
73MP0001348_abnormal_lacrimal_gland1.20876407
74MP0001697_abnormal_embryo_size1.19206852
75MP0005380_embryogenesis_phenotype1.18315578
76MP0001672_abnormal_embryogenesis/_devel1.18315578
77MP0003566_abnormal_cell_adhesion1.17682840
78MP0002080_prenatal_lethality1.17244269
79MP0005310_abnormal_salivary_gland1.17115425
80MP0002086_abnormal_extraembryonic_tissu1.16713549
81MP0005464_abnormal_platelet_physiology1.16211569
82MP0003656_abnormal_erythrocyte_physiolo1.15716122
83MP0003183_abnormal_peptide_metabolism1.14679781
84MP0008058_abnormal_DNA_repair1.12095201
85MP0003045_fibrosis1.10581183
86MP0001851_eye_inflammation1.09787766
87MP0003172_abnormal_lysosome_physiology1.08065669
88MP0003866_abnormal_defecation1.07975050
89MP0003828_pulmonary_edema1.07338685
90MP0004197_abnormal_fetal_growth/weight/1.06356034
91MP0002084_abnormal_developmental_patter1.04123005
92MP0003221_abnormal_cardiomyocyte_apopto1.00266852
93MP0009785_altered_susceptibility_to0.99737803
94MP0003075_altered_response_to0.98161057
95MP0000465_gastrointestinal_hemorrhage0.96644206
96MP0000733_abnormal_muscle_development0.95858315
97MP0002085_abnormal_embryonic_tissue0.95737844
98MP0002419_abnormal_innate_immunity0.94960924
99MP0005409_darkened_coat_color0.93597809
100MP0005666_abnormal_adipose_tissue0.92693315
101MP0001849_ear_inflammation0.92222362
102MP0003448_altered_tumor_morphology0.92159800
103MP0000569_abnormal_digit_pigmentation0.91577029
104MP0001845_abnormal_inflammatory_respons0.89942183
105MP0001853_heart_inflammation0.86895999
106MP0005023_abnormal_wound_healing0.85443480
107MP0004185_abnormal_adipocyte_glucose0.85218309
108MP0009764_decreased_sensitivity_to0.85088581
109MP0004264_abnormal_extraembryonic_tissu0.84766489
110MP0001915_intracranial_hemorrhage0.84272238
111MP0005621_abnormal_cell_physiology0.84043844
112MP0000371_diluted_coat_color0.83520627
113MP0003191_abnormal_cellular_cholesterol0.81935780
114MP0003329_amyloid_beta_deposits0.81431685
115MP0008469_abnormal_protein_level0.76990217
116MP0006054_spinal_hemorrhage0.76495839
117MP0010234_abnormal_vibrissa_follicle0.75973360
118MP0005375_adipose_tissue_phenotype0.75080255
119MP0002925_abnormal_cardiovascular_devel0.74800692
120MP0001663_abnormal_digestive_system0.73739795
121MP0009672_abnormal_birth_weight0.73661004
122MP0003091_abnormal_cell_migration0.73581511
123MP0005390_skeleton_phenotype0.73520308
124MP0004233_abnormal_muscle_weight0.73172004
125MP0003453_abnormal_keratinocyte_physiol0.69867659
126MP0005384_cellular_phenotype0.69515209
127MP0008932_abnormal_embryonic_tissue0.68807752
128MP0010630_abnormal_cardiac_muscle0.67756383
129MP0008874_decreased_physiological_sensi0.65987037
130MP0008004_abnormal_stomach_pH0.65646470
131MP0002933_joint_inflammation0.63899449
132MP0004381_abnormal_hair_follicle0.63853931

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.65386130
2Hyperacusis (HP:0010780)3.22679835
3T lymphocytopenia (HP:0005403)3.05239051
4Orchitis (HP:0100796)2.96364314
5Abnormality of T cell number (HP:0011839)2.94643920
6Recurrent viral infections (HP:0004429)2.90723872
7Recurrent bacterial skin infections (HP:0005406)2.89161883
8Retrobulbar optic neuritis (HP:0100654)2.86834114
9Optic neuritis (HP:0100653)2.86834114
10Ependymoma (HP:0002888)2.84354080
11Heterotopia (HP:0002282)2.82891394
12Increased density of long bones (HP:0006392)2.79429092
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.78808381
14Abnormality of macrophages (HP:0004311)2.77512734
15Abnormal delayed hypersensitivity skin test (HP:0002963)2.76440732
16Obstructive sleep apnea (HP:0002870)2.75528209
17Increased nuchal translucency (HP:0010880)2.73006627
18Nasal polyposis (HP:0100582)2.69792845
19Segmental peripheral demyelination/remyelination (HP:0003481)2.57056532
20Recurrent fungal infections (HP:0002841)2.55262837
21Abnormality of T cells (HP:0002843)2.54595794
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53990361
23Short 4th metacarpal (HP:0010044)2.53990361
24Thrombocytosis (HP:0001894)2.49956905
25Gastrointestinal stroma tumor (HP:0100723)2.48262851
26Basal cell carcinoma (HP:0002671)2.43326501
27Gastrointestinal infarctions (HP:0005244)2.42863593
28Papilloma (HP:0012740)2.42054797
29Verrucae (HP:0200043)2.42054797
30Chronic otitis media (HP:0000389)2.41801110
31Bicuspid aortic valve (HP:0001647)2.38917483
32Abnormality of the nasal mucosa (HP:0000433)2.34418076
33Gastrointestinal inflammation (HP:0004386)2.32955910
34Emphysema (HP:0002097)2.32453547
35Gingivitis (HP:0000230)2.30692702
36Meningitis (HP:0001287)2.29963017
37Cutis marmorata (HP:0000965)2.29917833
38Vasculitis (HP:0002633)2.29418498
39Sparse lateral eyebrow (HP:0005338)2.28149368
40Keratoconjunctivitis sicca (HP:0001097)2.19871220
41Fatigue (HP:0012378)2.19847070
42Insomnia (HP:0100785)2.18410300
43Astrocytoma (HP:0009592)2.17227027
44Abnormality of the astrocytes (HP:0100707)2.17227027
45Autoimmune thrombocytopenia (HP:0001973)2.14856903
46Trigonocephaly (HP:0000243)2.14074640
47Elfin facies (HP:0004428)2.13476372
48Slow saccadic eye movements (HP:0000514)2.13046868
49Prominent nose (HP:0000448)2.12387367
50Volvulus (HP:0002580)2.10308423
51Onion bulb formation (HP:0003383)2.10127094
52Recurrent bronchitis (HP:0002837)2.09997642
53Disproportionate tall stature (HP:0001519)2.09770283
54Eczematoid dermatitis (HP:0000976)2.06497343
55Inflammation of the large intestine (HP:0002037)2.05984021
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.05852973
57Obstructive lung disease (HP:0006536)2.03235301
58Chronic obstructive pulmonary disease (HP:0006510)2.03235301
59Panhypogammaglobulinemia (HP:0003139)2.02878241
60Anal stenosis (HP:0002025)2.02524012
61Abnormality of the anterior horn cell (HP:0006802)2.01843697
62Degeneration of anterior horn cells (HP:0002398)2.01843697
63Long eyelashes (HP:0000527)2.01185290
64Malignant gastrointestinal tract tumors (HP:0006749)1.99187222
65Gastrointestinal carcinoma (HP:0002672)1.99187222
66Amaurosis fugax (HP:0100576)1.98807622
67Deviation of the thumb (HP:0009603)1.98793509
68Chest pain (HP:0100749)1.98358579
69Abnormality of T cell physiology (HP:0011840)1.98275911
70Cellulitis (HP:0100658)1.97671185
71Broad face (HP:0000283)1.97631787
72Proximal placement of thumb (HP:0009623)1.97337679
73Hemorrhage of the eye (HP:0011885)1.96619609
74Posterior subcapsular cataract (HP:0007787)1.96606650
75Peripheral hypomyelination (HP:0007182)1.96385611
76Colitis (HP:0002583)1.95778501
77Cerebral aneurysm (HP:0004944)1.94804544
78Metaphyseal cupping (HP:0003021)1.93604308
79IgM deficiency (HP:0002850)1.93343512
80Interstitial pulmonary disease (HP:0006530)1.92061897
81High pitched voice (HP:0001620)1.91454167
82Spontaneous hematomas (HP:0007420)1.90944191
83Abnormality of the columella (HP:0009929)1.90885075
84Long palpebral fissure (HP:0000637)1.90737092
85Subacute progressive viral hepatitis (HP:0006572)1.90601667
86Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.89977576
87Keratoconjunctivitis (HP:0001096)1.89562123
88Cortical dysplasia (HP:0002539)1.89561689
89Recurrent gram-negative bacterial infections (HP:0005420)1.87837030
90Congenital stationary night blindness (HP:0007642)1.87254747
91Annular pancreas (HP:0001734)1.86113294
92Cafe-au-lait spot (HP:0000957)1.86039790
93Deep palmar crease (HP:0006191)1.84769986
94Aortic aneurysm (HP:0004942)1.84727081
95Combined immunodeficiency (HP:0005387)1.84520321
96Viral hepatitis (HP:0006562)1.84502748
97Germ cell neoplasia (HP:0100728)1.84332972
98Recurrent skin infections (HP:0001581)1.84323368
99Hand muscle atrophy (HP:0009130)1.84277327
100Skin tags (HP:0010609)1.82932746
101Pointed chin (HP:0000307)1.82456878
102Urticaria (HP:0001025)1.81788205
103Centrally nucleated skeletal muscle fibers (HP:0003687)1.81250497
104Osteomyelitis (HP:0002754)1.81183647
105Lymphopenia (HP:0001888)1.81095425
106Reticulocytosis (HP:0001923)1.80831717
107Medulloblastoma (HP:0002885)1.79477706
108Leiomyosarcoma (HP:0100243)1.78837898
109Uterine leiomyosarcoma (HP:0002891)1.78837898
110Arterial thrombosis (HP:0004420)1.78204205
111Myositis (HP:0100614)1.78019697
112Adenoma sebaceum (HP:0009720)1.78000783
113Angiofibromas (HP:0010615)1.78000783
114Dislocated radial head (HP:0003083)1.77505500
115Polygenic inheritance (HP:0010982)1.77164013
116Thoracic kyphosis (HP:0002942)1.77008010
117Renal duplication (HP:0000075)1.76198755
118Increased IgE level (HP:0003212)1.75842998
119Abnormality of the thoracic spine (HP:0100711)1.74939010
120Bowel incontinence (HP:0002607)1.74736457
121Abnormality of the 4th metacarpal (HP:0010012)1.74735827
122Dysmetric saccades (HP:0000641)1.74388534
123Neuronal loss in central nervous system (HP:0002529)1.73632639
124Intestinal fistula (HP:0100819)1.73164277
125Abnormality of the intervertebral disk (HP:0005108)1.72277407
126Macroorchidism (HP:0000053)1.71635233
127Abnormal number of incisors (HP:0011064)1.71411739
128Recurrent cutaneous fungal infections (HP:0011370)1.70822892
129Chronic mucocutaneous candidiasis (HP:0002728)1.70822892
130Broad palm (HP:0001169)1.70558308
131Lip pit (HP:0100267)1.70417859
132Mediastinal lymphadenopathy (HP:0100721)1.70301385
133Bony spicule pigmentary retinopathy (HP:0007737)1.69713240
134Hypertensive crisis (HP:0100735)1.69272031
135Decreased motor nerve conduction velocity (HP:0003431)1.69087796
136Ureteral stenosis (HP:0000071)1.66504283
137Recurrent abscess formation (HP:0002722)1.65996747
138Transitional cell carcinoma of the bladder (HP:0006740)1.65685105
139Abnormality of reticulocytes (HP:0004312)1.65543737
140Abnormal large intestine physiology (HP:0012700)1.65453784
141Spinal muscular atrophy (HP:0007269)1.65181938
142Selective tooth agenesis (HP:0001592)1.64589409
143Myelodysplasia (HP:0002863)1.64351287
144Poikilocytosis (HP:0004447)1.64245890
145Polycythemia (HP:0001901)1.64185477
146Abnormality of the radial head (HP:0003995)1.64067907
147Persistence of primary teeth (HP:0006335)1.64049391
148Restrictive lung disease (HP:0002091)1.63850658
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63725593
150Renovascular hypertension (HP:0100817)1.63501056
151Elevated erythrocyte sedimentation rate (HP:0003565)1.63409785
152Skull defect (HP:0001362)1.62577783
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62565929
154Increased IgM level (HP:0003496)1.61491974
155Pustule (HP:0200039)1.60914364
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.60826389
157Hypochromic anemia (HP:0001931)1.60627886
158Prolonged bleeding time (HP:0003010)1.60305948
159Pulmonary infiltrates (HP:0002113)1.58961343
160Ulnar bowing (HP:0003031)1.58723119
161Mask-like facies (HP:0000298)1.58501694
162Narrow palate (HP:0000189)1.58368214
163Encephalitis (HP:0002383)1.58130549
164Pelvic girdle muscle weakness (HP:0003749)1.58070585
165Agammaglobulinemia (HP:0004432)1.57742922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.28293920
2EEF2K4.14488562
3MAP3K103.83786536
4TRIB33.46843578
5PKN23.21418491
6MAP4K13.06007247
7CDK122.87809323
8RIPK42.79885938
9SMG12.63631135
10BUB12.46036109
11NEK22.20527771
12CDC72.19945526
13STK102.01960415
14PASK1.93479578
15JAK31.87597544
16FGFR31.86619129
17GRK61.79061580
18TYK21.76579861
19IRAK31.61317861
20MAP3K31.60343980
21RPS6KA41.45878160
22ERN11.44147570
23STK241.43698639
24PTK61.41632086
25MARK21.41443808
26CDK41.39550480
27BLK1.38664127
28FGFR41.38527890
29FLT31.38097882
30SCYL21.37328849
31NEK11.36790236
32EPHB11.34949030
33TTN1.33023782
34LRRK21.31596309
35ZAP701.30811120
36ITK1.24853497
37BTK1.24798161
38CDC42BPA1.21486133
39KSR21.18487240
40ALK1.16409157
41BRD41.15291277
42FES1.11730907
43CHUK1.11119031
44MAP3K81.09476381
45RIPK11.09242504
46CAMK1D1.08255590
47MAP2K31.08156822
48STK41.07660526
49JAK11.06764309
50PIM11.04145544
51ATR1.01167810
52TBK11.00896578
53RPS6KB20.98238491
54DYRK30.94619472
55TAOK10.94335054
56MAP3K10.92964288
57MATK0.92514466
58MAP3K70.91837231
59SIK30.90410700
60SIK20.90301685
61IRAK20.87969776
62ICK0.87634978
63MTOR0.86849132
64PAK40.85329757
65EPHA30.84511030
66IRAK10.83907017
67TESK20.82953639
68TXK0.82010642
69FGR0.81374062
70CSK0.80058235
71FGFR10.79573365
72IKBKE0.79278557
73SYK0.79212078
74MAP3K60.78478678
75TGFBR10.78267193
76WNK10.77681412
77PDGFRA0.77516335
78MELK0.77503086
79CDK90.76719039
80IKBKB0.76204135
81CHEK10.75272103
82MAP3K140.75085691
83HIPK20.74838649
84HCK0.74773052
85JAK20.73852863
86ACVR1B0.71062501
87MAPK70.69412508
88TNK20.68820607
89MAP3K20.68690798
90SGK30.68530000
91CDK60.68262019
92MAPK120.66980982
93CAMK40.65561324
94PRKD20.64446734
95CLK10.63739725
96CAMK1G0.62546412
97SIK10.62139516
98RPS6KA10.62007939
99BMX0.61674165
100MAP3K110.60872827
101PDPK10.58951346
102TSSK60.57855549
103YES10.57646311
104CDK70.57198277
105MAPK110.56610302
106LCK0.56412669
107LYN0.56079127
108CSF1R0.55806221
109DMPK0.55395999
110BRSK10.54638339
111CDK20.53967351
112PDK10.53823390
113RET0.53783792
114AURKB0.53351627
115RPS6KA20.50691168
116WEE10.49718546
117IRAK40.48261781
118TYRO30.47869637
119MAP2K20.46567783
120TAOK30.45432803
121TTK0.45278148
122TGFBR20.45169824
123TLK10.45101490
124MAPKAPK30.45074095
125CAMKK10.44983734
126RPS6KA60.44185465
127ATM0.43867025
128PLK10.43346811
129MAP3K130.43104281
130DYRK1B0.42951039
131SGK20.42375299
132PDGFRB0.42323256
133SGK4940.42227209
134SGK2230.42227209
135CHEK20.39688648
136RPS6KC10.39658596
137RPS6KL10.39658596
138MAPKAPK20.38748054
139TAOK20.37384134
140NTRK20.34922158
141MAP3K50.34472860
142KIT0.33291878

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.73055781
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22569073
3Primary immunodeficiency_Homo sapiens_hsa053402.05062078
4Chronic myeloid leukemia_Homo sapiens_hsa052202.04302119
5Base excision repair_Homo sapiens_hsa034101.88181827
6Mismatch repair_Homo sapiens_hsa034301.78851175
7Cell cycle_Homo sapiens_hsa041101.74333704
8T cell receptor signaling pathway_Homo sapiens_hsa046601.74095056
9Antigen processing and presentation_Homo sapiens_hsa046121.70729060
10B cell receptor signaling pathway_Homo sapiens_hsa046621.66974422
11Spliceosome_Homo sapiens_hsa030401.62800223
12Notch signaling pathway_Homo sapiens_hsa043301.57599708
13Leishmaniasis_Homo sapiens_hsa051401.57443618
14Acute myeloid leukemia_Homo sapiens_hsa052211.55462542
15Measles_Homo sapiens_hsa051621.54531018
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.49859573
17HTLV-I infection_Homo sapiens_hsa051661.46615899
18mRNA surveillance pathway_Homo sapiens_hsa030151.45734455
19Hepatitis C_Homo sapiens_hsa051601.43277393
20Herpes simplex infection_Homo sapiens_hsa051681.42999639
21Non-small cell lung cancer_Homo sapiens_hsa052231.41875774
22Apoptosis_Homo sapiens_hsa042101.40312759
23Osteoclast differentiation_Homo sapiens_hsa043801.39246101
24RNA transport_Homo sapiens_hsa030131.37901266
25Colorectal cancer_Homo sapiens_hsa052101.37200018
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37154953
27Viral carcinogenesis_Homo sapiens_hsa052031.36276083
28Viral myocarditis_Homo sapiens_hsa054161.34981721
29Hepatitis B_Homo sapiens_hsa051611.34094962
30mTOR signaling pathway_Homo sapiens_hsa041501.33765871
31Pancreatic cancer_Homo sapiens_hsa052121.32087430
32Other glycan degradation_Homo sapiens_hsa005111.32051740
33One carbon pool by folate_Homo sapiens_hsa006701.31306047
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30314134
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29535918
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26416021
37Toxoplasmosis_Homo sapiens_hsa051451.22011140
38MicroRNAs in cancer_Homo sapiens_hsa052061.21740325
39Small cell lung cancer_Homo sapiens_hsa052221.19250065
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.18830329
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.18125794
42Malaria_Homo sapiens_hsa051441.18011360
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14357819
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.13560775
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11586553
46p53 signaling pathway_Homo sapiens_hsa041151.07490153
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.07484873
48VEGF signaling pathway_Homo sapiens_hsa043701.06256890
49Epstein-Barr virus infection_Homo sapiens_hsa051691.05615310
50Prolactin signaling pathway_Homo sapiens_hsa049171.05527757
51Endometrial cancer_Homo sapiens_hsa052131.04034086
52Bladder cancer_Homo sapiens_hsa052191.03684754
53ErbB signaling pathway_Homo sapiens_hsa040121.03356433
54Influenza A_Homo sapiens_hsa051641.02752226
55Shigellosis_Homo sapiens_hsa051311.00897355
56Staphylococcus aureus infection_Homo sapiens_hsa051501.00422439
57Graft-versus-host disease_Homo sapiens_hsa053321.00034468
58Chemokine signaling pathway_Homo sapiens_hsa040620.99650193
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98745500
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98323413
61TNF signaling pathway_Homo sapiens_hsa046680.96359532
62African trypanosomiasis_Homo sapiens_hsa051430.96190633
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94469687
64Autoimmune thyroid disease_Homo sapiens_hsa053200.94248587
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.92478135
66Lysine degradation_Homo sapiens_hsa003100.92059414
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90888263
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.90544102
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.89905487
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89187991
71Choline metabolism in cancer_Homo sapiens_hsa052310.88596146
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88308500
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88023712
74Nucleotide excision repair_Homo sapiens_hsa034200.87774860
75Legionellosis_Homo sapiens_hsa051340.87682248
76GnRH signaling pathway_Homo sapiens_hsa049120.87304840
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84316350
78Insulin resistance_Homo sapiens_hsa049310.83630375
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82687620
80Systemic lupus erythematosus_Homo sapiens_hsa053220.82512709
81Glioma_Homo sapiens_hsa052140.81749915
82Pertussis_Homo sapiens_hsa051330.80174183
83Salmonella infection_Homo sapiens_hsa051320.79967426
84RNA degradation_Homo sapiens_hsa030180.79262340
85Inositol phosphate metabolism_Homo sapiens_hsa005620.78721094
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77546773
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77185089
88Prion diseases_Homo sapiens_hsa050200.76748568
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76713172
90HIF-1 signaling pathway_Homo sapiens_hsa040660.76129991
91Proteoglycans in cancer_Homo sapiens_hsa052050.76074123
92Platelet activation_Homo sapiens_hsa046110.74980929
93Thyroid cancer_Homo sapiens_hsa052160.73023493
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72739267
95FoxO signaling pathway_Homo sapiens_hsa040680.69705584
96Amoebiasis_Homo sapiens_hsa051460.68082881
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67986872
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67331647
99Adherens junction_Homo sapiens_hsa045200.67194534
100Renal cell carcinoma_Homo sapiens_hsa052110.66561763
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66046685
102Type II diabetes mellitus_Homo sapiens_hsa049300.65848689
103Estrogen signaling pathway_Homo sapiens_hsa049150.65760825
104Insulin signaling pathway_Homo sapiens_hsa049100.62688279
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62548593
106Endocytosis_Homo sapiens_hsa041440.62149459
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61510055
108Hematopoietic cell lineage_Homo sapiens_hsa046400.61441924
109Pathways in cancer_Homo sapiens_hsa052000.59885563
110Homologous recombination_Homo sapiens_hsa034400.59534421
111Fructose and mannose metabolism_Homo sapiens_hsa000510.57565955
112Dorso-ventral axis formation_Homo sapiens_hsa043200.57558784
113Non-homologous end-joining_Homo sapiens_hsa034500.57471142
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57060936
115Asthma_Homo sapiens_hsa053100.56981797
116AMPK signaling pathway_Homo sapiens_hsa041520.56032389
117Tuberculosis_Homo sapiens_hsa051520.54772276
118Oocyte meiosis_Homo sapiens_hsa041140.53978648
119Type I diabetes mellitus_Homo sapiens_hsa049400.53892403
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52650467
121Long-term potentiation_Homo sapiens_hsa047200.52594336
122Prostate cancer_Homo sapiens_hsa052150.52553855
123MAPK signaling pathway_Homo sapiens_hsa040100.52316232
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52063619
125Allograft rejection_Homo sapiens_hsa053300.51581531
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51323245
127Fanconi anemia pathway_Homo sapiens_hsa034600.51114561
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.47285816

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