GTPBP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.01096602
2nuclear pore complex assembly (GO:0051292)4.76563362
3nucleobase biosynthetic process (GO:0046112)4.65618574
4purine nucleobase biosynthetic process (GO:0009113)4.51429192
5mitotic metaphase plate congression (GO:0007080)4.48884071
6DNA unwinding involved in DNA replication (GO:0006268)4.37785138
7DNA replication initiation (GO:0006270)4.28738025
8folic acid-containing compound biosynthetic process (GO:0009396)4.11300769
9metaphase plate congression (GO:0051310)4.07033024
10DNA strand elongation involved in DNA replication (GO:0006271)4.02617083
11chromatin remodeling at centromere (GO:0031055)4.02612317
12CENP-A containing nucleosome assembly (GO:0034080)3.99626197
13DNA double-strand break processing (GO:0000729)3.99242783
14protein localization to kinetochore (GO:0034501)3.93580914
15DNA replication-dependent nucleosome organization (GO:0034723)3.91414441
16DNA replication-dependent nucleosome assembly (GO:0006335)3.91414441
17regulation of spindle organization (GO:0090224)3.90038039
18IMP biosynthetic process (GO:0006188)3.87697786
19DNA strand elongation (GO:0022616)3.85319357
20mitotic nuclear envelope disassembly (GO:0007077)3.83446937
21ribosome assembly (GO:0042255)3.82250353
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.77977227
23kinetochore organization (GO:0051383)3.74848730
24synapsis (GO:0007129)3.72010154
25mitotic sister chromatid cohesion (GO:0007064)3.68115188
26telomere maintenance via semi-conservative replication (GO:0032201)3.68095175
27DNA replication-independent nucleosome assembly (GO:0006336)3.66220121
28DNA replication-independent nucleosome organization (GO:0034724)3.66220121
29DNA replication checkpoint (GO:0000076)3.62638547
30response to pheromone (GO:0019236)3.60295902
31regulation of mitotic spindle organization (GO:0060236)3.59892927
32glycine metabolic process (GO:0006544)3.59871997
33regulation of mitotic spindle checkpoint (GO:1903504)3.57170849
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57170849
35mitotic chromosome condensation (GO:0007076)3.55495660
36maturation of SSU-rRNA (GO:0030490)3.51969629
37membrane disassembly (GO:0030397)3.51725674
38nuclear envelope disassembly (GO:0051081)3.51725674
39regulation of helicase activity (GO:0051095)3.50128993
40pore complex assembly (GO:0046931)3.49891979
41telomere maintenance via recombination (GO:0000722)3.48393147
42behavioral response to nicotine (GO:0035095)3.48068477
43resolution of meiotic recombination intermediates (GO:0000712)3.46427543
44attachment of spindle microtubules to kinetochore (GO:0008608)3.45804627
45mitotic recombination (GO:0006312)3.45218098
46histone exchange (GO:0043486)3.44635326
47regulation of centrosome cycle (GO:0046605)3.44154639
48respiratory chain complex IV assembly (GO:0008535)3.44079046
49IMP metabolic process (GO:0046040)3.38448300
50recombinational repair (GO:0000725)3.33935194
51double-strand break repair via homologous recombination (GO:0000724)3.33670848
52folic acid metabolic process (GO:0046655)3.32591309
53regulation of sister chromatid cohesion (GO:0007063)3.29666644
54positive regulation of chromosome segregation (GO:0051984)3.28830074
55piRNA metabolic process (GO:0034587)3.28581636
56protein K11-linked deubiquitination (GO:0035871)3.28185869
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.26898370
58* ribosome biogenesis (GO:0042254)3.25428930
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.25119731
60establishment of chromosome localization (GO:0051303)3.24857316
61water-soluble vitamin biosynthetic process (GO:0042364)3.24487680
62spindle checkpoint (GO:0031577)3.23987058
63centriole replication (GO:0007099)3.23178796
64formation of translation preinitiation complex (GO:0001731)3.21135692
65serine family amino acid biosynthetic process (GO:0009070)3.17230017
66regulation of DNA endoreduplication (GO:0032875)3.16337892
67protein localization to chromosome, centromeric region (GO:0071459)3.15033037
68reciprocal meiotic recombination (GO:0007131)3.14559089
69reciprocal DNA recombination (GO:0035825)3.14559089
70telomere maintenance via telomere lengthening (GO:0010833)3.13770539
71DNA duplex unwinding (GO:0032508)3.13011687
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12426830
73tetrahydrofolate metabolic process (GO:0046653)3.12319589
74regulation of meiosis I (GO:0060631)3.12287120
75DNA geometric change (GO:0032392)3.12148271
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.11470874
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.11470874
78mitotic spindle checkpoint (GO:0071174)3.11221245
79kinetochore assembly (GO:0051382)3.10433618
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10410092
81cellular ketone body metabolic process (GO:0046950)3.09390284
82mitotic sister chromatid segregation (GO:0000070)3.09131177
83histone-serine phosphorylation (GO:0035404)3.07315653
84negative regulation of chromosome segregation (GO:0051985)3.07085738
85prenylation (GO:0097354)3.06836977
86protein prenylation (GO:0018342)3.06836977
87meiotic chromosome segregation (GO:0045132)3.06768373
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.06320365
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06320365
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06320365
91negative regulation of sister chromatid segregation (GO:0033046)3.06320365
92sister chromatid segregation (GO:0000819)3.06132853
93DNA methylation involved in gamete generation (GO:0043046)3.06097604
94regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05823041
95regulation of chromosome segregation (GO:0051983)3.05634037
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05498757
97spindle assembly checkpoint (GO:0071173)3.03609294
98L-serine metabolic process (GO:0006563)3.03265199
99mitotic spindle assembly checkpoint (GO:0007094)3.02113206
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01146416
101mitochondrial respiratory chain complex I assembly (GO:0032981)3.01146416
102NADH dehydrogenase complex assembly (GO:0010257)3.01146416
103methionine biosynthetic process (GO:0009086)3.00337731
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00222774
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00222774
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.00222774
107regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99620491
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99520685
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98804014
110regulation of hexokinase activity (GO:1903299)2.98316510
111regulation of glucokinase activity (GO:0033131)2.98316510
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98278908
113neural tube formation (GO:0001841)2.97379919
114maturation of 5.8S rRNA (GO:0000460)2.92862225
115male meiosis I (GO:0007141)2.92641900
116regulation of mitotic sister chromatid separation (GO:0010965)2.91909688
117regulation of mitotic sister chromatid segregation (GO:0033047)2.91909688
118regulation of sister chromatid segregation (GO:0033045)2.91909688
119ketone body metabolic process (GO:1902224)2.91525054
120indolalkylamine metabolic process (GO:0006586)2.91347075
121fucose catabolic process (GO:0019317)2.91157046
122L-fucose metabolic process (GO:0042354)2.91157046
123L-fucose catabolic process (GO:0042355)2.91157046
124monoubiquitinated protein deubiquitination (GO:0035520)2.90894070
125protein complex biogenesis (GO:0070271)2.90483987
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89258559
127cullin deneddylation (GO:0010388)2.89010864
128chromatin assembly or disassembly (GO:0006333)2.88976918
129protein K6-linked ubiquitination (GO:0085020)2.87716222
130mitochondrial respiratory chain complex assembly (GO:0033108)2.85993906
131cytochrome complex assembly (GO:0017004)2.85654950
132folic acid-containing compound metabolic process (GO:0006760)2.84695760
133regulation of gene silencing by RNA (GO:0060966)2.84216671
134regulation of posttranscriptional gene silencing (GO:0060147)2.84216671
135regulation of gene silencing by miRNA (GO:0060964)2.84216671
136histone H2A acetylation (GO:0043968)2.81921172
137regulation of double-strand break repair via homologous recombination (GO:0010569)2.80795778
138detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80443775
139regulation of centriole replication (GO:0046599)2.80289821
140detection of light stimulus involved in sensory perception (GO:0050962)2.78261379
141detection of light stimulus involved in visual perception (GO:0050908)2.78261379
142methionine metabolic process (GO:0006555)2.77658118
143replication fork processing (GO:0031297)2.77300921
144pteridine-containing compound biosynthetic process (GO:0042559)2.76076510
145kynurenine metabolic process (GO:0070189)2.74011189
146transcription elongation from RNA polymerase I promoter (GO:0006362)2.73926921
147telomere organization (GO:0032200)2.73532730
148serine family amino acid metabolic process (GO:0009069)2.73391548
149* ribonucleoprotein complex biogenesis (GO:0022613)2.73223055
150ATP-dependent chromatin remodeling (GO:0043044)2.72224571
151pseudouridine synthesis (GO:0001522)2.71534041
152telomere maintenance (GO:0000723)2.71157944
153telomere maintenance via telomerase (GO:0007004)2.71052891
154isotype switching (GO:0045190)2.70726472
155indolalkylamine catabolic process (GO:0046218)2.70494323
156tryptophan catabolic process (GO:0006569)2.70494323
157indole-containing compound catabolic process (GO:0042436)2.70494323
158L-methionine salvage (GO:0071267)2.70305637
159L-methionine biosynthetic process (GO:0071265)2.70305637
160amino acid salvage (GO:0043102)2.70305637
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70187179
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70048452
163protein deneddylation (GO:0000338)2.69722703
164DNA-dependent DNA replication (GO:0006261)2.67629188
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67148485
166somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67148485
167postreplication repair (GO:0006301)2.66091259
168photoreceptor cell maintenance (GO:0045494)2.65217191
169protein-cofactor linkage (GO:0018065)2.64085973
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.64043929
171nonmotile primary cilium assembly (GO:0035058)2.59671079
172preassembly of GPI anchor in ER membrane (GO:0016254)2.59520837
173meiotic cell cycle (GO:0051321)2.58178552
174intra-S DNA damage checkpoint (GO:0031573)2.57668153
175DNA catabolic process, exonucleolytic (GO:0000738)2.55857663
176positive regulation of histone H3-K4 methylation (GO:0051571)2.52423202
177polyol catabolic process (GO:0046174)2.52188344
178S-adenosylmethionine metabolic process (GO:0046500)2.50804898
179oxidative demethylation (GO:0070989)2.50650910
180double-strand break repair (GO:0006302)2.50597222
181signal peptide processing (GO:0006465)2.50470289
182retinal cone cell development (GO:0046549)2.45941649
183organelle disassembly (GO:1903008)2.45591960
184replicative senescence (GO:0090399)2.44333497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.33578225
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.29376586
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.21797770
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.00475649
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28587610
6ZNF274_21170338_ChIP-Seq_K562_Hela3.15307462
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99672585
8AR_21909140_ChIP-Seq_LNCAP_Human2.96356699
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87246186
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84086298
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79718448
12* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77100791
13EWS_26573619_Chip-Seq_HEK293_Human2.58805011
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58671518
15GBX2_23144817_ChIP-Seq_PC3_Human2.57674125
16IGF1R_20145208_ChIP-Seq_DFB_Human2.57052659
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56167313
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53633219
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.53528161
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52699537
21VDR_22108803_ChIP-Seq_LS180_Human2.51237918
22FUS_26573619_Chip-Seq_HEK293_Human2.48170540
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.46996273
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38867391
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.35590540
26TAF15_26573619_Chip-Seq_HEK293_Human2.33123366
27* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28377184
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.25561898
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.23580875
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.21837410
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16009057
32* ETS1_20019798_ChIP-Seq_JURKAT_Human2.14994644
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14374249
34* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13538999
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07421335
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06053950
37* XRN2_22483619_ChIP-Seq_HELA_Human2.03014043
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99094962
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98427215
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95301292
41P300_19829295_ChIP-Seq_ESCs_Human1.91439559
42* VDR_23849224_ChIP-Seq_CD4+_Human1.91375174
43* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89656004
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.83808866
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81852225
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78489400
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78312195
48* ER_23166858_ChIP-Seq_MCF-7_Human1.77310595
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74663064
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72970390
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72317067
52FOXP3_21729870_ChIP-Seq_TREG_Human1.70513287
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65304327
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65016253
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62455193
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61416947
57DCP1A_22483619_ChIP-Seq_HELA_Human1.61120156
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60347956
59EZH2_22144423_ChIP-Seq_EOC_Human1.60038894
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59432016
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58963260
62ELK1_19687146_ChIP-ChIP_HELA_Human1.57437055
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57372175
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53163975
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52756387
66STAT3_23295773_ChIP-Seq_U87_Human1.51861173
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51603662
68TTF2_22483619_ChIP-Seq_HELA_Human1.50586909
69GABP_19822575_ChIP-Seq_HepG2_Human1.49948437
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.49780321
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49746432
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49312745
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48810800
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48552915
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46238024
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45392024
77CBP_20019798_ChIP-Seq_JUKART_Human1.45392024
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.44947870
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44487975
80KDM5A_27292631_Chip-Seq_BREAST_Human1.44360118
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43877477
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42653527
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.42519853
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41736500
85SMAD4_21799915_ChIP-Seq_A2780_Human1.41548082
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41094137
87IRF1_19129219_ChIP-ChIP_H3396_Human1.40265835
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39652683
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37790481
90TCF4_23295773_ChIP-Seq_U87_Human1.34226814
91* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34063932
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33767980
93EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32190844
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31507796
95AR_25329375_ChIP-Seq_VCAP_Human1.30862293
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30203719
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29647908
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29502561
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.29484869
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29189067
101BCAT_22108803_ChIP-Seq_LS180_Human1.27635750
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27189268
103TP53_22573176_ChIP-Seq_HFKS_Human1.26896927
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26844158
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26412565
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26412565
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26412565
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23476758
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20480096
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20017346
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.19968596
112NANOG_19829295_ChIP-Seq_ESCs_Human1.19042987
113SOX2_19829295_ChIP-Seq_ESCs_Human1.19042987
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17035664
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16699259
116* TCF4_22108803_ChIP-Seq_LS180_Human1.15802491
117SRF_21415370_ChIP-Seq_HL-1_Mouse1.15355158
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.14792786
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13516922
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.13439762
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12740981
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12728233
123FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11133222
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11005736
125CIITA_25753668_ChIP-Seq_RAJI_Human1.10970554
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10935465
127* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10227644
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09873627
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09786105
130CDX2_22108803_ChIP-Seq_LS180_Human1.09724818
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09027326
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08674254
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07747342
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07445539
135P53_22387025_ChIP-Seq_ESCs_Mouse1.07434963
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.07184114
137RUNX2_22187159_ChIP-Seq_PCA_Human1.07149240
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06359416
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06304844
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.06044587
141HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05881879
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04479459
143TFEB_21752829_ChIP-Seq_HELA_Human1.03731107
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03320148
145SMAD4_21741376_ChIP-Seq_EPCs_Human1.03279529
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02745522
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02587388
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01634123
149NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01621846
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.99957465
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.99812141
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99510346
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99510346
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99483957
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.99483957
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99175699
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98870644
158JUN_21703547_ChIP-Seq_K562_Human0.98794270
159NANOG_21062744_ChIP-ChIP_HESCs_Human0.98521155
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97719776
161* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97488804
162TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96880217
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96566216
164CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96354582
165ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95726321
166TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94387540
167NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93482761
168MYC_18940864_ChIP-ChIP_HL60_Human0.92973668
169SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92700662
170* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88983602
171RXR_22158963_ChIP-Seq_LIVER_Mouse0.88377840
172PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87708560
173HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87363948
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86194849
175SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85821690
176SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83725905
177NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83660975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41857563
2MP0010094_abnormal_chromosome_stability4.16275723
3MP0004957_abnormal_blastocyst_morpholog3.80568561
4MP0000569_abnormal_digit_pigmentation3.56922466
5MP0003111_abnormal_nucleus_morphology3.41188552
6MP0003806_abnormal_nucleotide_metabolis3.34131797
7MP0003077_abnormal_cell_cycle3.25711429
8MP0008057_abnormal_DNA_replication3.25527225
9MP0002139_abnormal_hepatobiliary_system2.96683376
10MP0000372_irregular_coat_pigmentation2.60260165
11MP0002102_abnormal_ear_morphology2.49362696
12MP0003123_paternal_imprinting2.47969704
13MP0008058_abnormal_DNA_repair2.40619176
14MP0005360_urolithiasis2.33572378
15MP0008932_abnormal_embryonic_tissue2.33531219
16MP0010352_gastrointestinal_tract_polyps2.32339713
17MP0003195_calcinosis2.29089470
18MP0005085_abnormal_gallbladder_physiolo2.18531452
19MP0001730_embryonic_growth_arrest2.16336699
20MP0005551_abnormal_eye_electrophysiolog2.14703399
21MP0010307_abnormal_tumor_latency2.13841112
22MP0002837_dystrophic_cardiac_calcinosis2.11576872
23MP0008007_abnormal_cellular_replicative2.07658766
24MP0006072_abnormal_retinal_apoptosis2.07635311
25MP0003718_maternal_effect1.98425079
26MP0003787_abnormal_imprinting1.94115315
27MP0005365_abnormal_bile_salt1.86786575
28MP0003646_muscle_fatigue1.83163892
29MP0000350_abnormal_cell_proliferation1.82428021
30MP0001672_abnormal_embryogenesis/_devel1.76654237
31MP0005380_embryogenesis_phenotype1.76654237
32MP0005253_abnormal_eye_physiology1.71956901
33MP0001697_abnormal_embryo_size1.70638807
34MP0009697_abnormal_copulation1.68187207
35MP0003890_abnormal_embryonic-extraembry1.66014023
36MP0004147_increased_porphyrin_level1.65008106
37MP0004043_abnormal_pH_regulation1.63305268
38MP0009046_muscle_twitch1.62480995
39MP0010234_abnormal_vibrissa_follicle1.60492928
40MP0003984_embryonic_growth_retardation1.58752644
41MP0002088_abnormal_embryonic_growth/wei1.55798839
42MP0005174_abnormal_tail_pigmentation1.52681147
43MP0004197_abnormal_fetal_growth/weight/1.52261981
44MP0003567_abnormal_fetal_cardiomyocyte1.51647834
45MP0002163_abnormal_gland_morphology1.47661274
46MP0003786_premature_aging1.47569285
47MP0002085_abnormal_embryonic_tissue1.47564465
48MP0001293_anophthalmia1.46674611
49MP0010030_abnormal_orbit_morphology1.46100239
50MP0004142_abnormal_muscle_tone1.45630659
51MP0002084_abnormal_developmental_patter1.44867677
52MP0002396_abnormal_hematopoietic_system1.44748081
53MP0002086_abnormal_extraembryonic_tissu1.40257618
54MP0009053_abnormal_anal_canal1.39457133
55MP0002876_abnormal_thyroid_physiology1.38449395
56MP0002095_abnormal_skin_pigmentation1.38262530
57MP0008877_abnormal_DNA_methylation1.38076613
58MP0004215_abnormal_myocardial_fiber1.37643264
59MP0002080_prenatal_lethality1.37520322
60MP0000383_abnormal_hair_follicle1.34935663
61MP0003880_abnormal_central_pattern1.33812465
62MP0008872_abnormal_physiological_respon1.33363262
63MP0003186_abnormal_redox_activity1.29494823
64MP0001968_abnormal_touch/_nociception1.29194120
65MP0003937_abnormal_limbs/digits/tail_de1.27893301
66MP0005645_abnormal_hypothalamus_physiol1.27729811
67MP0005379_endocrine/exocrine_gland_phen1.26619188
68MP0005075_abnormal_melanosome_morpholog1.25612127
69MP0000537_abnormal_urethra_morphology1.25324897
70MP0006276_abnormal_autonomic_nervous1.24718957
71MP0000015_abnormal_ear_pigmentation1.24573116
72MP0006035_abnormal_mitochondrial_morpho1.23811638
73MP0001501_abnormal_sleep_pattern1.21932547
74MP0005266_abnormal_metabolism1.20641223
75MP0001986_abnormal_taste_sensitivity1.20021094
76MP0009672_abnormal_birth_weight1.19910864
77MP0000631_abnormal_neuroendocrine_gland1.17894953
78MP0003121_genomic_imprinting1.17872133
79MP0006054_spinal_hemorrhage1.17029913
80MP0005083_abnormal_biliary_tract1.16563072
81MP0003950_abnormal_plasma_membrane1.14236130
82MP0003705_abnormal_hypodermis_morpholog1.13015158
83MP0003136_yellow_coat_color1.12540254
84MP0002736_abnormal_nociception_after1.11659003
85MP0005084_abnormal_gallbladder_morpholo1.10600426
86MP0002210_abnormal_sex_determination1.09475221
87MP0003252_abnormal_bile_duct1.09405379
88MP0002272_abnormal_nervous_system1.08286849
89MP0009745_abnormal_behavioral_response1.08058030
90MP0003941_abnormal_skin_development1.07622411
91MP0008875_abnormal_xenobiotic_pharmacok1.04388884
92MP0002234_abnormal_pharynx_morphology1.04141966
93MP0002092_abnormal_eye_morphology1.00500053
94MP0001145_abnormal_male_reproductive0.99431089
95MP0005647_abnormal_sex_gland0.99351511
96MP0000490_abnormal_crypts_of0.99276476
97MP0001984_abnormal_olfaction0.98155642
98MP0001915_intracranial_hemorrhage0.97575807
99MP0003698_abnormal_male_reproductive0.97237197
100MP0002009_preneoplasia0.97193923
101MP0004808_abnormal_hematopoietic_stem0.96901040
102MP0001485_abnormal_pinna_reflex0.96852000
103MP0005410_abnormal_fertilization0.96570790
104MP0005408_hypopigmentation0.95986272
105MP0005187_abnormal_penis_morphology0.95412892
106MP0001324_abnormal_eye_pigmentation0.95111583
107MP0000313_abnormal_cell_death0.94139304
108MP0002019_abnormal_tumor_incidence0.93804085
109MP0003315_abnormal_perineum_morphology0.92757543
110MP0005248_abnormal_Harderian_gland0.92247729
111MP0005332_abnormal_amino_acid0.91989060
112MP0002111_abnormal_tail_morphology0.91708694
113MP0003119_abnormal_digestive_system0.91285710
114MP0004924_abnormal_behavior0.90937215
115MP0005386_behavior/neurological_phenoty0.90937215
116MP0001286_abnormal_eye_development0.90690886
117MP0000653_abnormal_sex_gland0.90376670
118MP0001119_abnormal_female_reproductive0.88788142
119MP0001188_hyperpigmentation0.87604488
120MP0002928_abnormal_bile_duct0.87031527
121MP0008995_early_reproductive_senescence0.85198421
122MP0000647_abnormal_sebaceous_gland0.83617723
123MP0005220_abnormal_exocrine_pancreas0.82900496
124MP0004084_abnormal_cardiac_muscle0.82816335
125MP0008789_abnormal_olfactory_epithelium0.82509696
126MP0010678_abnormal_skin_adnexa0.82215234
127MP0005395_other_phenotype0.81622528
128MP0001529_abnormal_vocalization0.81514671
129MP0009703_decreased_birth_body0.81207465
130MP0004742_abnormal_vestibular_system0.80645725
131MP0004133_heterotaxia0.80130242
132MP0002090_abnormal_vision0.79877903
133MP0002938_white_spotting0.79866348
134MP0003943_abnormal_hepatobiliary_system0.79711602
135MP0001849_ear_inflammation0.79505469
136MP0003221_abnormal_cardiomyocyte_apopto0.79337618
137MP0008775_abnormal_heart_ventricle0.79063375
138MP0001929_abnormal_gametogenesis0.77308026
139MP0000371_diluted_coat_color0.77198501
140MP0002697_abnormal_eye_size0.76913676
141MP0005195_abnormal_posterior_eye0.76367558
142MP0002160_abnormal_reproductive_system0.76253904
143MP0000566_synostosis0.75385810
144MP0000598_abnormal_liver_morphology0.75089973
145MP0000516_abnormal_urinary_system0.72415651
146MP0005367_renal/urinary_system_phenotyp0.72415651
147MP0006292_abnormal_olfactory_placode0.71562473
148MP0001545_abnormal_hematopoietic_system0.70749560
149MP0005397_hematopoietic_system_phenotyp0.70749560
150MP0003936_abnormal_reproductive_system0.70730640
151MP0003699_abnormal_female_reproductive0.69104632
152MP0005389_reproductive_system_phenotype0.69052487
153MP0000432_abnormal_head_morphology0.66923353
154MP0000609_abnormal_liver_physiology0.66747926
155MP0002282_abnormal_trachea_morphology0.66575219
156MP0002249_abnormal_larynx_morphology0.66485653
157MP0003115_abnormal_respiratory_system0.64939168
158MP0001661_extended_life_span0.62945695
159MP0006036_abnormal_mitochondrial_physio0.61898098
160MP0001764_abnormal_homeostasis0.60686458
161MP0003942_abnormal_urinary_system0.60519649
162MP0000427_abnormal_hair_cycle0.60210251

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.99601800
2Pancreatic cysts (HP:0001737)3.85526190
3Hyperglycinemia (HP:0002154)3.62874554
4Pancreatic fibrosis (HP:0100732)3.54111962
5Abnormality of midbrain morphology (HP:0002418)3.42449848
6Molar tooth sign on MRI (HP:0002419)3.42449848
7Hypobetalipoproteinemia (HP:0003563)3.34610938
8Selective tooth agenesis (HP:0001592)3.33907566
9Abnormality of chromosome stability (HP:0003220)3.33877624
10Colon cancer (HP:0003003)3.29147795
11Chromsome breakage (HP:0040012)3.25383099
12Abnormality of the labia minora (HP:0012880)3.21405311
13Breast hypoplasia (HP:0003187)3.21203365
14Abnormality of the renal cortex (HP:0011035)3.20246182
15Aplasia/Hypoplasia of the tibia (HP:0005772)3.02927934
16Medial flaring of the eyebrow (HP:0010747)3.01891340
17Impulsivity (HP:0100710)2.96280066
18Congenital stationary night blindness (HP:0007642)2.94707615
19True hermaphroditism (HP:0010459)2.93415411
20Oral leukoplakia (HP:0002745)2.91156548
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.85508298
22Intrahepatic cholestasis (HP:0001406)2.84850336
23Medulloblastoma (HP:0002885)2.81958999
24Abnormality of pyrimidine metabolism (HP:0004353)2.80131034
25Abnormality of serine family amino acid metabolism (HP:0010894)2.78440654
26Abnormality of glycine metabolism (HP:0010895)2.78440654
27Patellar aplasia (HP:0006443)2.77847405
28Hyperglycinuria (HP:0003108)2.76142029
29Nephronophthisis (HP:0000090)2.71334973
30Renal cortical cysts (HP:0000803)2.70589075
31Ependymoma (HP:0002888)2.68480962
32Absent radius (HP:0003974)2.67918940
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65357509
34Abnormality of alanine metabolism (HP:0010916)2.65357509
35Hyperalaninemia (HP:0003348)2.65357509
36Aplasia involving forearm bones (HP:0009822)2.65104910
37Absent forearm bone (HP:0003953)2.65104910
38Abnormality of the preputium (HP:0100587)2.56850779
39Rhabdomyosarcoma (HP:0002859)2.56384648
40Short tibia (HP:0005736)2.56267658
41Volvulus (HP:0002580)2.56241494
42Aplasia/Hypoplasia of the patella (HP:0006498)2.54729127
43Abnormality of the renal medulla (HP:0100957)2.53798336
44Lipid accumulation in hepatocytes (HP:0006561)2.53570815
45Congenital primary aphakia (HP:0007707)2.51497262
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50915433
47Supernumerary spleens (HP:0009799)2.49857080
48Meckel diverticulum (HP:0002245)2.48769847
49Tubular atrophy (HP:0000092)2.48453927
50Gait imbalance (HP:0002141)2.48173892
51Abnormality of methionine metabolism (HP:0010901)2.46652860
52Reticulocytopenia (HP:0001896)2.45989358
53Bile duct proliferation (HP:0001408)2.43049615
54Abnormal biliary tract physiology (HP:0012439)2.43049615
55Abnormality of serum amino acid levels (HP:0003112)2.42797888
56Nephrogenic diabetes insipidus (HP:0009806)2.42630102
57Abnormality of the ileum (HP:0001549)2.40025713
58Hyperventilation (HP:0002883)2.39513808
59Increased hepatocellular lipid droplets (HP:0006565)2.39219812
60Gaze-evoked nystagmus (HP:0000640)2.39155426
61Spastic diplegia (HP:0001264)2.38483998
62Rough bone trabeculation (HP:0100670)2.36225029
63Abnormal lung lobation (HP:0002101)2.34729551
64Carpal bone hypoplasia (HP:0001498)2.33749706
65Attenuation of retinal blood vessels (HP:0007843)2.32417007
66Aplasia/Hypoplasia of the fovea (HP:0008060)2.31274932
67Hypoplasia of the fovea (HP:0007750)2.31274932
68Stenosis of the external auditory canal (HP:0000402)2.27716851
69Increased CSF lactate (HP:0002490)2.25799860
70Abolished electroretinogram (ERG) (HP:0000550)2.25756054
71Progressive inability to walk (HP:0002505)2.24590687
72Abnormal spermatogenesis (HP:0008669)2.23328132
73Abnormality of the anterior horn cell (HP:0006802)2.22986163
74Degeneration of anterior horn cells (HP:0002398)2.22986163
75Abnormal number of incisors (HP:0011064)2.20942364
76Fair hair (HP:0002286)2.20702433
77Duodenal stenosis (HP:0100867)2.20267194
78Small intestinal stenosis (HP:0012848)2.20267194
79Proximal placement of thumb (HP:0009623)2.18369541
80Type II lissencephaly (HP:0007260)2.17913110
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.17788120
82Shawl scrotum (HP:0000049)2.17303580
83Hypolipoproteinemia (HP:0010981)2.17261086
84Aplasia/Hypoplasia of the sternum (HP:0006714)2.16811928
85Hyperammonemia (HP:0001987)2.16292528
86Deviation of the thumb (HP:0009603)2.14232220
87Genital tract atresia (HP:0001827)2.12604617
88Nephroblastoma (Wilms tumor) (HP:0002667)2.12597877
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11304423
90Hypothermia (HP:0002045)2.09091742
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08918409
92Glioma (HP:0009733)2.08342129
93Absent thumb (HP:0009777)2.08319494
94Mitochondrial inheritance (HP:0001427)2.07425537
95Myelodysplasia (HP:0002863)2.06955413
96Embryonal renal neoplasm (HP:0011794)2.05731685
97Hepatocellular carcinoma (HP:0001402)2.05377401
98Methylmalonic acidemia (HP:0002912)2.04213870
993-Methylglutaconic aciduria (HP:0003535)2.03969265
100Abnormality of sulfur amino acid metabolism (HP:0004339)2.03963666
101Neoplasm of the liver (HP:0002896)2.03621570
102Aplasia/Hypoplasia of the uvula (HP:0010293)2.03448927
103Acute necrotizing encephalopathy (HP:0006965)2.01721754
104Acute encephalopathy (HP:0006846)2.00941274
105Lissencephaly (HP:0001339)2.00658592
106Poor coordination (HP:0002370)1.99694572
107Astrocytoma (HP:0009592)1.99345552
108Abnormality of the astrocytes (HP:0100707)1.99345552
10911 pairs of ribs (HP:0000878)1.99215447
110Vaginal atresia (HP:0000148)1.98913055
111Abnormality of the fovea (HP:0000493)1.98497723
112Cystic liver disease (HP:0006706)1.98416174
113Abnormality of the duodenum (HP:0002246)1.97958345
114Progressive macrocephaly (HP:0004481)1.97308393
115Protruding tongue (HP:0010808)1.96762020
116Abnormal biliary tract morphology (HP:0012440)1.96086714
117Squamous cell carcinoma (HP:0002860)1.96013477
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95902890
119Biliary tract neoplasm (HP:0100574)1.95394071
120Neoplasm of the pancreas (HP:0002894)1.95235703
121Megaloblastic anemia (HP:0001889)1.93548248
122Facial hemangioma (HP:0000329)1.92231456
123Furrowed tongue (HP:0000221)1.92021847
124Neoplasm of the oral cavity (HP:0100649)1.91798559
125Atresia of the external auditory canal (HP:0000413)1.90491837
126Neoplasm of striated muscle (HP:0009728)1.90423095
127Inability to walk (HP:0002540)1.88749618
128Chronic hepatic failure (HP:0100626)1.88011944
129Sloping forehead (HP:0000340)1.86637786
130Skull defect (HP:0001362)1.85057131
131Small hand (HP:0200055)1.83989498
132Abnormal trabecular bone morphology (HP:0100671)1.83699136
133Oligodactyly (HP:0012165)1.83338744
134Aplastic anemia (HP:0001915)1.81613866
135Chorioretinal atrophy (HP:0000533)1.81599616
136Cerebellar dysplasia (HP:0007033)1.81411712
137Ectopic kidney (HP:0000086)1.80476704
138Astigmatism (HP:0000483)1.80026459
139Increased serum lactate (HP:0002151)1.80000003
140Broad-based gait (HP:0002136)1.79678818
141Cutaneous melanoma (HP:0012056)1.78338684
142Tubulointerstitial nephritis (HP:0001970)1.77783393
143Neoplasm of the colon (HP:0100273)1.77587662
144Male pseudohermaphroditism (HP:0000037)1.77228675
145Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77012100
146Clubbing of toes (HP:0100760)1.76994658
147Bone marrow hypocellularity (HP:0005528)1.76936374
148Abnormal drinking behavior (HP:0030082)1.76443665
149Polydipsia (HP:0001959)1.76443665
150Deep philtrum (HP:0002002)1.75234866
151Ovarian neoplasm (HP:0100615)1.74513770
152Premature graying of hair (HP:0002216)1.73773337
153Sclerocornea (HP:0000647)1.73228438
154Generalized hypopigmentation of hair (HP:0011358)1.73050006
155Cafe-au-lait spot (HP:0000957)1.72727835
156Abnormality of the pons (HP:0007361)1.72701329
157Hepatic necrosis (HP:0002605)1.72418491
158Anencephaly (HP:0002323)1.71523737
159Congenital hepatic fibrosis (HP:0002612)1.71280733
160Renal Fanconi syndrome (HP:0001994)1.71029929
161Large for gestational age (HP:0001520)1.70556330
162Proximal tubulopathy (HP:0000114)1.69711513
163Missing ribs (HP:0000921)1.69563663
164Preaxial hand polydactyly (HP:0001177)1.68688510
165Gastrointestinal carcinoma (HP:0002672)1.68667882
166Malignant gastrointestinal tract tumors (HP:0006749)1.68667882
167Postaxial foot polydactyly (HP:0001830)1.67597063
168Increased nuchal translucency (HP:0010880)1.67352736
169Median cleft lip (HP:0000161)1.66825227
170Oligodactyly (hands) (HP:0001180)1.65892011
171Hepatocellular necrosis (HP:0001404)1.65124311
172Postaxial hand polydactyly (HP:0001162)1.64620770
173Pendular nystagmus (HP:0012043)1.63966809
174Abnormality of macular pigmentation (HP:0008002)1.63601172
175Short 4th metacarpal (HP:0010044)1.63523834
176Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63523834
177Hypochromic microcytic anemia (HP:0004840)1.63259044
178Horseshoe kidney (HP:0000085)1.62294977
179Depressed nasal tip (HP:0000437)1.61067836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.18317038
2WEE13.95393759
3BUB13.50932621
4CDC73.37565220
5BMPR1B2.85374762
6NEK12.81640624
7TTK2.80668525
8SRPK12.56566126
9NEK22.55175481
10TRIM282.50879404
11BRSK22.46935452
12MAP3K42.42958538
13MKNK12.12072798
14TSSK62.12024195
15EIF2AK32.11785686
16STK38L1.95993897
17AKT31.95441456
18ACVR1B1.94159097
19WNK31.89370639
20WNK41.88012254
21PLK31.84925755
22LATS11.82352355
23PLK41.82199149
24PLK11.79937192
25PASK1.78528946
26EPHA21.77909334
27ATR1.75892239
28GRK11.70548331
29ADRBK21.69970098
30CDK71.69855176
31PINK11.69722565
32STK391.67157270
33AURKB1.65750682
34BCKDK1.64413694
35MAP4K21.61440655
36FRK1.61196049
37MAPK131.54919077
38ZAK1.52029712
39MKNK21.49870330
40RPS6KB21.49702399
41CDK121.44932790
42MAP3K81.41845405
43CHEK21.41221079
44TAF11.39330425
45ERBB41.38236509
46TAOK31.31780590
47PBK1.24751960
48OXSR11.21979350
49BRD41.18989694
50CHEK11.18385372
51TGFBR11.16150533
52STK161.15371143
53VRK11.15238093
54CASK1.15009871
55BRSK11.13783848
56BRAF1.10688566
57STK31.09672732
58CDK41.07500607
59STK101.06266124
60DYRK31.05324758
61STK41.03045229
62RPS6KA41.02577949
63MELK0.99401428
64CDK60.98761802
65FLT30.98013887
66TNIK0.97909713
67ATM0.97715524
68MAP2K70.92666224
69INSRR0.90692756
70PKN20.90105813
71PLK20.87484114
72TLK10.85731929
73CDK80.85265953
74AURKA0.82799416
75NME20.81645945
76CAMKK20.81035076
77CDK20.80579085
78FGFR20.79806357
79PAK40.76741935
80MET0.74426790
81BMPR20.74057757
82PRKCE0.71977761
83TESK20.69674817
84CDK10.67989883
85CSNK2A20.65954050
86MST40.64506858
87PAK30.64506526
88NTRK30.64148362
89CSNK1G30.63919424
90EIF2AK20.63346011
91CDK30.62238353
92TEC0.61538803
93FGFR10.58738326
94PIK3CA0.57707951
95CSNK1G10.57249002
96NUAK10.56312999
97PIM10.55987975
98CSNK1A1L0.55221706
99ADRBK10.55196127
100CSNK2A10.53801299
101BCR0.52520834
102PDK30.52437895
103PDK40.52437895
104PRKCG0.50632982
105CSNK1E0.50351753
106EEF2K0.49426424
107MARK30.49310541
108NLK0.49217815
109MTOR0.48164638
110OBSCN0.47899331
111SCYL20.47681770
112PDK20.46316904
113MAPK110.46170392
114PRKCI0.44458571
115TRPM70.43365513
116STK110.43099794
117STK240.42430126
118MAP3K30.41850789
119PHKG20.41414276
120PHKG10.41414276
121NME10.41093536
122PRKAA20.40564209
123WNK10.40067836
124CAMK2A0.39357792
125LRRK20.38694534
126MAPKAPK50.38578711
127ALK0.38102580
128DYRK20.36329111
129PIK3CG0.36206339
130VRK20.35485705
131CSNK1D0.35325463
132PNCK0.34513254
133PRKAA10.34248621
134LATS20.33418331
135PRKDC0.33297584
136IRAK10.31658021
137AKT20.31039712
138MAP2K40.30292748
139CLK10.30132795
140NEK60.29154136
141MAPK140.27394933
142RPS6KA50.25664256
143RPS6KB10.25235850
144ERBB30.22274889
145CCNB10.22268163
146YES10.21558930
147CSNK1G20.21380437
148AKT10.21297286

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89580251
2Mismatch repair_Homo sapiens_hsa034303.57279756
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25433838
4One carbon pool by folate_Homo sapiens_hsa006703.01300115
5RNA transport_Homo sapiens_hsa030132.66394856
6Protein export_Homo sapiens_hsa030602.56048306
7Spliceosome_Homo sapiens_hsa030402.51221645
8Homologous recombination_Homo sapiens_hsa034402.47653451
9RNA polymerase_Homo sapiens_hsa030202.42522481
10Cell cycle_Homo sapiens_hsa041102.37088315
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35827191
12Base excision repair_Homo sapiens_hsa034102.30280184
13Nucleotide excision repair_Homo sapiens_hsa034202.28858951
14Selenocompound metabolism_Homo sapiens_hsa004502.22936382
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04675483
16Phototransduction_Homo sapiens_hsa047441.99627341
17Pyrimidine metabolism_Homo sapiens_hsa002401.96535291
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91797801
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88179605
20Fanconi anemia pathway_Homo sapiens_hsa034601.87012372
21Proteasome_Homo sapiens_hsa030501.81810046
22Oxidative phosphorylation_Homo sapiens_hsa001901.73044267
23Non-homologous end-joining_Homo sapiens_hsa034501.71152401
24Linoleic acid metabolism_Homo sapiens_hsa005911.69894223
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.60212271
26Basal transcription factors_Homo sapiens_hsa030221.60136131
27RNA degradation_Homo sapiens_hsa030181.59230256
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.58264984
29Ribosome_Homo sapiens_hsa030101.57836278
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.47842779
31Biosynthesis of amino acids_Homo sapiens_hsa012301.47655000
32Nitrogen metabolism_Homo sapiens_hsa009101.46300239
33Ether lipid metabolism_Homo sapiens_hsa005651.45096345
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44634094
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.42021038
36Parkinsons disease_Homo sapiens_hsa050121.39199479
37Vitamin B6 metabolism_Homo sapiens_hsa007501.35628324
38p53 signaling pathway_Homo sapiens_hsa041151.33628851
39Folate biosynthesis_Homo sapiens_hsa007901.32141647
40Nicotine addiction_Homo sapiens_hsa050331.30025482
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29229619
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27795586
43mRNA surveillance pathway_Homo sapiens_hsa030151.26425989
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26218066
45Olfactory transduction_Homo sapiens_hsa047401.17124213
46Carbon metabolism_Homo sapiens_hsa012001.16682010
47Systemic lupus erythematosus_Homo sapiens_hsa053221.16563253
48Arginine biosynthesis_Homo sapiens_hsa002201.13463303
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13000374
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12640441
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10706262
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08115640
53Propanoate metabolism_Homo sapiens_hsa006401.06640238
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06527145
55Huntingtons disease_Homo sapiens_hsa050161.06445313
56Purine metabolism_Homo sapiens_hsa002300.97328567
57Regulation of autophagy_Homo sapiens_hsa041400.97247801
58ABC transporters_Homo sapiens_hsa020100.96719906
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95042100
60Circadian rhythm_Homo sapiens_hsa047100.92165685
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91667289
62Fatty acid degradation_Homo sapiens_hsa000710.90527716
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88141126
64Taste transduction_Homo sapiens_hsa047420.87446566
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86584381
66Pentose phosphate pathway_Homo sapiens_hsa000300.85552302
67Tryptophan metabolism_Homo sapiens_hsa003800.84217534
68Lysine degradation_Homo sapiens_hsa003100.81679513
69Alzheimers disease_Homo sapiens_hsa050100.80400511
70Peroxisome_Homo sapiens_hsa041460.79909809
71Glutathione metabolism_Homo sapiens_hsa004800.79589678
72Arginine and proline metabolism_Homo sapiens_hsa003300.79097424
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78055191
74Thyroid cancer_Homo sapiens_hsa052160.74712194
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74080551
76Retinol metabolism_Homo sapiens_hsa008300.72703397
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69350187
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67800373
79Pyruvate metabolism_Homo sapiens_hsa006200.65571200
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65466169
81Vitamin digestion and absorption_Homo sapiens_hsa049770.64997922
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64791086
83Dorso-ventral axis formation_Homo sapiens_hsa043200.64691604
84Complement and coagulation cascades_Homo sapiens_hsa046100.64386660
85Viral carcinogenesis_Homo sapiens_hsa052030.64254378
86Butanoate metabolism_Homo sapiens_hsa006500.62184353
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62152005
88Serotonergic synapse_Homo sapiens_hsa047260.60838607
89Epstein-Barr virus infection_Homo sapiens_hsa051690.60563291
90Chemical carcinogenesis_Homo sapiens_hsa052040.60170166
91beta-Alanine metabolism_Homo sapiens_hsa004100.59753831
92MicroRNAs in cancer_Homo sapiens_hsa052060.59743722
93Tyrosine metabolism_Homo sapiens_hsa003500.59309779
94Small cell lung cancer_Homo sapiens_hsa052220.58824621
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57546888
96Morphine addiction_Homo sapiens_hsa050320.53896884
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53106767
98Glutamatergic synapse_Homo sapiens_hsa047240.52081256
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51867256
100Oocyte meiosis_Homo sapiens_hsa041140.51647522
101Fatty acid elongation_Homo sapiens_hsa000620.51645443
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.51482280
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51141209
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50610212
105Fatty acid metabolism_Homo sapiens_hsa012120.50572194
106Herpes simplex infection_Homo sapiens_hsa051680.50147858
107Ovarian steroidogenesis_Homo sapiens_hsa049130.50009544
108TGF-beta signaling pathway_Homo sapiens_hsa043500.49170317
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48659813
110Arachidonic acid metabolism_Homo sapiens_hsa005900.48594813
111Basal cell carcinoma_Homo sapiens_hsa052170.47941542
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46176217
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46062792
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43545322
115GABAergic synapse_Homo sapiens_hsa047270.43342930
116Metabolic pathways_Homo sapiens_hsa011000.42819875
117Cardiac muscle contraction_Homo sapiens_hsa042600.42752479
118Bladder cancer_Homo sapiens_hsa052190.42032252
119Histidine metabolism_Homo sapiens_hsa003400.40062366
120Sulfur relay system_Homo sapiens_hsa041220.39588629
121Phenylalanine metabolism_Homo sapiens_hsa003600.39424763
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38641102
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.37816396
124Fatty acid biosynthesis_Homo sapiens_hsa000610.35399393
125Hippo signaling pathway_Homo sapiens_hsa043900.35213970
126Long-term depression_Homo sapiens_hsa047300.33920427
127Collecting duct acid secretion_Homo sapiens_hsa049660.33253836
128Steroid biosynthesis_Homo sapiens_hsa001000.30693332
129Caffeine metabolism_Homo sapiens_hsa002320.30170488
130HTLV-I infection_Homo sapiens_hsa051660.30090273
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29780936
132Sulfur metabolism_Homo sapiens_hsa009200.29660059
133Fat digestion and absorption_Homo sapiens_hsa049750.29593049
134Starch and sucrose metabolism_Homo sapiens_hsa005000.28696659
135Fructose and mannose metabolism_Homo sapiens_hsa000510.28354469

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