GTPBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.08567828
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66068749
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66068749
4positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.65929595
5positive regulation of gamma-delta T cell activation (GO:0046645)4.60739856
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49085207
7negative regulation of cell killing (GO:0031342)4.49085207
8antigen processing and presentation of endogenous antigen (GO:0019883)4.34335181
9mannose metabolic process (GO:0006013)4.13517330
10regulation of gamma-delta T cell differentiation (GO:0045586)4.05075497
11positive regulation of interferon-alpha production (GO:0032727)3.79974749
12macroautophagy (GO:0016236)3.79201131
13cellular response to virus (GO:0098586)3.74498323
14regulation of gamma-delta T cell activation (GO:0046643)3.73640815
15response to type I interferon (GO:0034340)3.72733355
16positive thymic T cell selection (GO:0045059)3.72206980
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.69846582
18regulation of interferon-alpha production (GO:0032647)3.57089325
19regulation of histone H3-K27 methylation (GO:0061085)3.49134753
20type I interferon signaling pathway (GO:0060337)3.49006219
21cellular response to type I interferon (GO:0071357)3.49006219
22response to peptidoglycan (GO:0032494)3.45376562
23regulation of early endosome to late endosome transport (GO:2000641)3.40888458
24regulation of RNA export from nucleus (GO:0046831)3.37924597
25Golgi transport vesicle coating (GO:0048200)3.37086088
26COPI coating of Golgi vesicle (GO:0048205)3.37086088
27protein targeting to Golgi (GO:0000042)3.32506679
28oxygen transport (GO:0015671)3.30832604
29positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.25360951
30establishment of protein localization to Golgi (GO:0072600)3.24914736
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17667912
32negative regulation of erythrocyte differentiation (GO:0045647)3.16421609
33protoporphyrinogen IX metabolic process (GO:0046501)3.11684211
34regulation of nucleobase-containing compound transport (GO:0032239)3.09862203
35nuclear pore complex assembly (GO:0051292)3.00635073
36interferon-gamma-mediated signaling pathway (GO:0060333)2.99241483
37positive regulation of histone deacetylation (GO:0031065)2.97819569
38negative regulation of fatty acid biosynthetic process (GO:0045717)2.96301995
39positive T cell selection (GO:0043368)2.96065940
40gas transport (GO:0015669)2.95020150
41neutrophil activation involved in immune response (GO:0002283)2.94738421
42modulation by symbiont of host cellular process (GO:0044068)2.94374853
43erythrocyte maturation (GO:0043249)2.93918787
44thymic T cell selection (GO:0045061)2.93020593
45regulation of integrin activation (GO:0033623)2.88289940
46negative thymic T cell selection (GO:0045060)2.84343525
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.83780637
48iron ion import (GO:0097286)2.81767254
49positive regulation of B cell differentiation (GO:0045579)2.80817551
50negative T cell selection (GO:0043383)2.78973146
51modulation by virus of host process (GO:0019054)2.77903610
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77657488
53regulation of necroptotic process (GO:0060544)2.77356983
54T cell selection (GO:0045058)2.77289652
55erythrocyte development (GO:0048821)2.76051766
56activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74811314
57glucose 6-phosphate metabolic process (GO:0051156)2.73432210
58JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.72478929
59regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71846299
60intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.71797434
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.70339073
62detection of other organism (GO:0098543)2.67105137
63detection of bacterium (GO:0016045)2.65774300
64germinal center formation (GO:0002467)2.65681262
65positive regulation of nuclease activity (GO:0032075)2.65133954
66regulation of response to osmotic stress (GO:0047484)2.62078517
67regulation of translational fidelity (GO:0006450)2.60527456
68regulation of mast cell degranulation (GO:0043304)2.60301900
69platelet formation (GO:0030220)2.59222257
70striated muscle atrophy (GO:0014891)2.57360523
713-UTR-mediated mRNA stabilization (GO:0070935)2.55454167
72endoplasmic reticulum unfolded protein response (GO:0030968)2.52187392
73regulation of leukocyte degranulation (GO:0043300)2.52117077
74positive regulation of cellular amide metabolic process (GO:0034250)2.51855821
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51500198
76negative regulation of necroptotic process (GO:0060546)2.51073816
77antigen processing and presentation via MHC class Ib (GO:0002475)2.50486425
78skeletal muscle adaptation (GO:0043501)2.50467777
79definitive hemopoiesis (GO:0060216)2.50357330
80positive regulation of p38MAPK cascade (GO:1900745)2.50183643
81regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.49945634
82regulation of nuclease activity (GO:0032069)2.47532807
83cellular response to thyroid hormone stimulus (GO:0097067)2.46988886
84response to thyroid hormone (GO:0097066)2.46587008
85myeloid cell development (GO:0061515)2.45466267
86cell-substrate junction assembly (GO:0007044)2.44876447
87growth hormone receptor signaling pathway (GO:0060396)2.44103569
88poly(A)+ mRNA export from nucleus (GO:0016973)2.43715758
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43110473
90response to interleukin-15 (GO:0070672)2.42200682
91B cell receptor signaling pathway (GO:0050853)2.41578224
92embryonic process involved in female pregnancy (GO:0060136)2.41059320
93ER-nucleus signaling pathway (GO:0006984)2.39788601
94positive regulation of natural killer cell differentiation (GO:0032825)2.39174404
95focal adhesion assembly (GO:0048041)2.37699699
96cell-substrate adherens junction assembly (GO:0007045)2.37699699
97cGMP-mediated signaling (GO:0019934)2.37627505
98positive regulation of interferon-beta production (GO:0032728)2.37240879
99cellular response to unfolded protein (GO:0034620)2.37042475
100regulation of ARF protein signal transduction (GO:0032012)2.36567398
101regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34440326
102granulocyte differentiation (GO:0030851)2.33857779
103positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33470750
104stress fiber assembly (GO:0043149)2.33111315
105regulation of B cell receptor signaling pathway (GO:0050855)2.32685644
106response to laminar fluid shear stress (GO:0034616)2.32322375
107protein localization to endosome (GO:0036010)2.32318312
108regulation of T cell tolerance induction (GO:0002664)2.31955677
109regulation of platelet aggregation (GO:0090330)2.31838626
110hypotonic response (GO:0006971)2.31760632
111regulation of mast cell activation involved in immune response (GO:0033006)2.30454684
112regulation of cholesterol homeostasis (GO:2000188)2.30121236
113positive regulation of receptor recycling (GO:0001921)2.30112591
114positive regulation of protein deacetylation (GO:0090312)2.30097799
115positive regulation of Rap GTPase activity (GO:0032854)2.29820141
116regulation of B cell differentiation (GO:0045577)2.28623725
117megakaryocyte development (GO:0035855)2.26727571
118negative regulation of viral release from host cell (GO:1902187)2.26272981
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26081127
120adherens junction assembly (GO:0034333)2.24563792
121detection of external biotic stimulus (GO:0098581)2.23548885
122nuclear pore organization (GO:0006999)2.23466948
123regulation of ARF GTPase activity (GO:0032312)2.22125034
124NIK/NF-kappaB signaling (GO:0038061)2.21925318
125regulation of p38MAPK cascade (GO:1900744)2.21566775
126negative regulation of bone resorption (GO:0045779)2.21561612
127T cell migration (GO:0072678)2.19879736
128macrophage activation involved in immune response (GO:0002281)2.19078967
129regulation of cholesterol storage (GO:0010885)2.18641913
130regulation of alpha-beta T cell proliferation (GO:0046640)2.17905760
131cellular response to interferon-gamma (GO:0071346)2.17196359
132positive regulation by symbiont of host defense response (GO:0052509)2.17181779
133modulation by symbiont of host defense response (GO:0052031)2.17181779
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.17181779
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.17181779
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.17181779
137modulation by symbiont of host immune response (GO:0052553)2.17181779
138negative regulation of viral entry into host cell (GO:0046597)2.16567014
139phosphatidylinositol dephosphorylation (GO:0046856)2.15852931
140thrombin receptor signaling pathway (GO:0070493)2.15239323
141activation of JUN kinase activity (GO:0007257)2.14950382
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.12651115
143cellular response to growth hormone stimulus (GO:0071378)2.12286553
144phospholipid dephosphorylation (GO:0046839)2.09297193
145natural killer cell differentiation (GO:0001779)2.09181813
146positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.09064088
147muscle atrophy (GO:0014889)2.08784433
148response to muramyl dipeptide (GO:0032495)2.08745400
149positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.06245744
150positive regulation of phagocytosis (GO:0050766)2.05611887
151phospholipid homeostasis (GO:0055091)2.03187448
152regulation of viral entry into host cell (GO:0046596)2.02424930
153T cell costimulation (GO:0031295)2.01122957
154cortical actin cytoskeleton organization (GO:0030866)2.01116562
155positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.00842412
156regulation of regulatory T cell differentiation (GO:0045589)2.00483996
157regulation of erythrocyte differentiation (GO:0045646)2.00215790
158regulation of viral release from host cell (GO:1902186)1.99383398
159protein kinase C signaling (GO:0070528)1.98477454
160positive regulation of actin cytoskeleton reorganization (GO:2000251)1.97788772
161lymphocyte costimulation (GO:0031294)1.96937312
162I-kappaB phosphorylation (GO:0007252)1.96859953
163cytokine biosynthetic process (GO:0042089)1.96787531
164T-helper 1 type immune response (GO:0042088)1.96225148
165mucosal-associated lymphoid tissue development (GO:0048537)1.95758373
166Peyers patch development (GO:0048541)1.95758373
167angiogenesis involved in wound healing (GO:0060055)1.95161267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.51165938
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28292661
3E2F7_22180533_ChIP-Seq_HELA_Human3.12402205
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07708948
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79949004
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54658142
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.21534068
8SCL_19346495_ChIP-Seq_HPC-7_Human2.15416407
9RUNX_20019798_ChIP-Seq_JUKART_Human2.11151581
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09825519
11TCF7_22412390_ChIP-Seq_EML_Mouse2.09091122
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04143128
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03639182
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.02904152
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00454807
16GATA1_22025678_ChIP-Seq_K562_Human1.96902156
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96493544
18FOXM1_23109430_ChIP-Seq_U2OS_Human1.96027092
19KDM2B_26808549_Chip-Seq_DND41_Human1.94981572
20GATA1_19941826_ChIP-Seq_K562_Human1.92261485
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88633787
22MYC_22102868_ChIP-Seq_BL_Human1.85623835
23VDR_21846776_ChIP-Seq_THP-1_Human1.84076490
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83271947
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82266232
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.80410177
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.79824800
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76995232
29MAF_26560356_Chip-Seq_TH1_Human1.72647028
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71209914
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70601194
32LXR_22292898_ChIP-Seq_THP-1_Human1.68453234
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67165019
34SPI1_23127762_ChIP-Seq_K562_Human1.64556670
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.61347159
36ZNF263_19887448_ChIP-Seq_K562_Human1.60544461
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.59245091
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59243044
39GATA2_19941826_ChIP-Seq_K562_Human1.54271242
40UTX_26944678_Chip-Seq_JUKART_Human1.52610608
41VDR_24763502_ChIP-Seq_THP-1_Human1.52511178
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52122795
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.48466269
44* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46179708
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45282794
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.44544204
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44084656
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43318407
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43247841
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43093191
51* ATF3_27146783_Chip-Seq_COLON_Human1.41972356
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41166164
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39923044
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.39759672
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38902710
56MYB_26560356_Chip-Seq_TH2_Human1.37654095
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37523992
58* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37143443
59CLOCK_20551151_ChIP-Seq_293T_Human1.36050762
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.35736867
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33052045
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.32146750
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31147693
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30663699
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.30599275
66KDM2B_26808549_Chip-Seq_K562_Human1.30558152
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27808352
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27511529
69DROSHA_22980978_ChIP-Seq_HELA_Human1.26719652
70* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25936284
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.25220094
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.25112689
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23640721
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23130127
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20864253
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20854906
77MYB_26560356_Chip-Seq_TH1_Human1.20663287
78RACK7_27058665_Chip-Seq_MCF-7_Human1.19858561
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18978199
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.18784054
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15978105
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15909864
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14488155
84* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14474144
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.14389358
86P68_20966046_ChIP-Seq_HELA_Human1.13665092
87CREB1_26743006_Chip-Seq_LNCaP_Human1.13614884
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13392119
89* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12969489
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11925539
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11167770
92NCOR1_26117541_ChIP-Seq_K562_Human1.11101797
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10967485
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10218218
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10190762
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.10086111
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09126252
98* TBX20_22328084_ChIP-Seq_HEART_Mouse1.09098799
99* TBX20_22080862_ChIP-Seq_HEART_Mouse1.09098799
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08602186
101SPI1_23547873_ChIP-Seq_NB4_Human1.08339507
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07819922
103VDR_24787735_ChIP-Seq_THP-1_Human1.07044994
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05882037
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.05700088
106GATA3_27048872_Chip-Seq_THYMUS_Human1.05089660
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04492477
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03992004
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03703451
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03668685
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02168036
112TFEB_21752829_ChIP-Seq_HELA_Human1.02054370
113SMC4_20622854_ChIP-Seq_HELA_Human1.00820167
114FOXA2_19822575_ChIP-Seq_HepG2_Human1.00523569
115* MAF_26560356_Chip-Seq_TH2_Human0.99585304
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99196224
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99144354
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99085060
119* ELF1_20517297_ChIP-Seq_JURKAT_Human0.98693142
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98028456
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97892682
122* BCOR_27268052_Chip-Seq_Bcells_Human0.97806367
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97108683
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96601458
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.96218296
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95951515
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95820227
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.95489324
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95301441
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94188066
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.92968941
132* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91720676
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90560886
134SMAD_19615063_ChIP-ChIP_OVARY_Human0.90223899
135PU_27001747_Chip-Seq_BMDM_Mouse0.89999820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.37584406
2MP0004510_myositis3.00189396
3MP0000685_abnormal_immune_system2.86057789
4MP0003303_peritoneal_inflammation2.69894734
5MP0001835_abnormal_antigen_presentation2.64128803
6MP0003300_gastrointestinal_ulcer2.59481642
7MP0003191_abnormal_cellular_cholesterol2.51365454
8MP0005387_immune_system_phenotype2.44026539
9MP0001790_abnormal_immune_system2.44026539
10MP0010234_abnormal_vibrissa_follicle2.37527046
11MP0004947_skin_inflammation2.21004994
12MP0001873_stomach_inflammation2.18962212
13MP0002166_altered_tumor_susceptibility2.13615285
14MP0001800_abnormal_humoral_immune2.11214304
15MP0003436_decreased_susceptibility_to2.09212860
16MP0003656_abnormal_erythrocyte_physiolo1.99786194
17MP0005671_abnormal_response_to1.99293538
18MP0008438_abnormal_cutaneous_collagen1.99244875
19MP0008961_abnormal_basal_metabolism1.98640728
20MP0005464_abnormal_platelet_physiology1.98372466
21MP0005025_abnormal_response_to1.93179991
22MP0000858_altered_metastatic_potential1.92061940
23MP0003453_abnormal_keratinocyte_physiol1.88573066
24MP0002822_catalepsy1.84666717
25MP0002452_abnormal_antigen_presenting1.80980876
26MP0005000_abnormal_immune_tolerance1.80831239
27MP0004147_increased_porphyrin_level1.80819104
28MP0009785_altered_susceptibility_to1.73630305
29MP0002723_abnormal_immune_serum1.73608368
30MP0008260_abnormal_autophagy1.70711831
31MP0001819_abnormal_immune_cell1.68949655
32MP0005167_abnormal_blood-brain_barrier1.68291039
33MP0002420_abnormal_adaptive_immunity1.67366035
34MP0005409_darkened_coat_color1.65713111
35MP0000569_abnormal_digit_pigmentation1.65160607
36MP0003866_abnormal_defecation1.63196315
37MP0010155_abnormal_intestine_physiology1.60059314
38MP0004185_abnormal_adipocyte_glucose1.59300592
39MP0002419_abnormal_innate_immunity1.58828064
40MP0004130_abnormal_muscle_cell1.54657454
41MP0006082_CNS_inflammation1.52888000
42MP0001849_ear_inflammation1.52466427
43MP0009278_abnormal_bone_marrow1.51519048
44MP0003045_fibrosis1.49359363
45MP0002006_tumorigenesis1.47819709
46MP0002398_abnormal_bone_marrow1.46628373
47MP0003705_abnormal_hypodermis_morpholog1.43895294
48MP0005083_abnormal_biliary_tract1.42179682
49MP0002837_dystrophic_cardiac_calcinosis1.41426400
50MP0009333_abnormal_splenocyte_physiolog1.39818550
51MP0003763_abnormal_thymus_physiology1.36094060
52MP0000678_abnormal_parathyroid_gland1.33184646
53MP0004858_abnormal_nervous_system1.32975233
54MP0005310_abnormal_salivary_gland1.31918817
55MP0002148_abnormal_hypersensitivity_rea1.31837492
56MP0003183_abnormal_peptide_metabolism1.31572081
57MP0000716_abnormal_immune_system1.29883729
58MP0010307_abnormal_tumor_latency1.29637933
59MP0000604_amyloidosis1.28718234
60MP0001348_abnormal_lacrimal_gland1.28478655
61MP0010352_gastrointestinal_tract_polyps1.25907613
62MP0004233_abnormal_muscle_weight1.24538205
63MP0005666_abnormal_adipose_tissue1.24388177
64MP0005670_abnormal_white_adipose1.23311032
65MP0003172_abnormal_lysosome_physiology1.22835139
66MP0000751_myopathy1.22548161
67MP0005023_abnormal_wound_healing1.21805485
68MP0003075_altered_response_to1.20345250
69MP0002405_respiratory_system_inflammati1.18187418
70MP0002138_abnormal_hepatobiliary_system1.16072560
71MP0001845_abnormal_inflammatory_respons1.15808623
72MP0005166_decreased_susceptibility_to1.12543267
73MP0002877_abnormal_melanocyte_morpholog1.12276956
74MP0004084_abnormal_cardiac_muscle1.11108416
75MP0009840_abnormal_foam_cell1.10966742
76MP0002132_abnormal_respiratory_system1.09654982
77MP0001666_abnormal_nutrient_absorption1.09317283
78MP0001533_abnormal_skeleton_physiology1.07880400
79MP0002429_abnormal_blood_cell1.07403217
80MP0000689_abnormal_spleen_morphology1.07032500
81MP0005058_abnormal_lysosome_morphology1.05207308
82MP0005397_hematopoietic_system_phenotyp1.05133341
83MP0001545_abnormal_hematopoietic_system1.05133341
84MP0009931_abnormal_skin_appearance1.04885292
85MP0002722_abnormal_immune_system1.04784009
86MP0003252_abnormal_bile_duct1.04320662
87MP0008469_abnormal_protein_level1.02306973
88MP0002998_abnormal_bone_remodeling1.01370288
89MP0003111_abnormal_nucleus_morphology1.00544876
90MP0000343_altered_response_to0.99955969
91MP0003566_abnormal_cell_adhesion0.99757339
92MP0003724_increased_susceptibility_to0.99274004
93MP0003828_pulmonary_edema0.98969474
94MP0005501_abnormal_skin_physiology0.98724581
95MP0000609_abnormal_liver_physiology0.98500666
96MP0005621_abnormal_cell_physiology0.98340448
97MP0004264_abnormal_extraembryonic_tissu0.97727623
98MP0004036_abnormal_muscle_relaxation0.96561862
99MP0002796_impaired_skin_barrier0.95872813
100MP0010329_abnormal_lipoprotein_level0.94858979
101MP0005076_abnormal_cell_differentiation0.94047473
102MP0004808_abnormal_hematopoietic_stem0.93989828
103MP0002971_abnormal_brown_adipose0.93426238
104MP0000015_abnormal_ear_pigmentation0.93005801
105MP0005360_urolithiasis0.90323282
106MP0005164_abnormal_response_to0.89518579
107MP0003950_abnormal_plasma_membrane0.89451469
108MP0000003_abnormal_adipose_tissue0.89135145
109MP0004087_abnormal_muscle_fiber0.88994014
110MP0009764_decreased_sensitivity_to0.88392944
111MP0001663_abnormal_digestive_system0.87989803
112MP0005375_adipose_tissue_phenotype0.87609829
113MP0002928_abnormal_bile_duct0.86575066
114MP0003329_amyloid_beta_deposits0.86007229
115MP0003091_abnormal_cell_migration0.85911978
116MP0002060_abnormal_skin_morphology0.85672640
117MP0001851_eye_inflammation0.85478857
118MP0004381_abnormal_hair_follicle0.85102172
119MP0008004_abnormal_stomach_pH0.84171611
120MP0008775_abnormal_heart_ventricle0.83359925
121MP0002254_reproductive_system_inflammat0.81341590
122MP0000767_abnormal_smooth_muscle0.81153884
123MP0004272_abnormal_basement_membrane0.80355652
124MP0002086_abnormal_extraembryonic_tissu0.79874499
125MP0003448_altered_tumor_morphology0.78790944
126MP0001765_abnormal_ion_homeostasis0.76578605
127MP0000703_abnormal_thymus_morphology0.76395990
128MP0010630_abnormal_cardiac_muscle0.76259951
129MP0001915_intracranial_hemorrhage0.75393035
130MP0005174_abnormal_tail_pigmentation0.73988809
131MP0001730_embryonic_growth_arrest0.73381764
132MP0002396_abnormal_hematopoietic_system0.73286503
133MP0004145_abnormal_muscle_electrophysio0.72706402
134MP0003795_abnormal_bone_structure0.72185266
135MP0001216_abnormal_epidermal_layer0.71652270

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)3.90964418
2Nasal polyposis (HP:0100582)3.23234350
3Abnormality of the heme biosynthetic pathway (HP:0010472)3.22559112
4Cholecystitis (HP:0001082)3.15609527
5Abnormal gallbladder physiology (HP:0012438)3.15609527
6Colitis (HP:0002583)3.13187350
7Abnormality of the nasal mucosa (HP:0000433)3.08280821
8Eczematoid dermatitis (HP:0000976)3.01941051
9Aortic aneurysm (HP:0004942)2.98450581
10Autoimmune thrombocytopenia (HP:0001973)2.95792858
11Inflammation of the large intestine (HP:0002037)2.89723059
12Abnormality of the fingertips (HP:0001211)2.89206889
13Poikilocytosis (HP:0004447)2.86257200
14Menorrhagia (HP:0000132)2.83629485
15Gastrointestinal inflammation (HP:0004386)2.81337726
16Recurrent fungal infections (HP:0002841)2.80114487
17Chronic otitis media (HP:0000389)2.76182751
18Recurrent viral infections (HP:0004429)2.68732973
19Hypertensive crisis (HP:0100735)2.67748861
20Ankyloglossia (HP:0010296)2.63689813
21Protrusio acetabuli (HP:0003179)2.54118147
22Recurrent bacterial skin infections (HP:0005406)2.53376170
23Hyperacusis (HP:0010780)2.52541507
24Heterotopia (HP:0002282)2.51975571
25Reticulocytosis (HP:0001923)2.50738636
26Disproportionate tall stature (HP:0001519)2.50631468
27Pustule (HP:0200039)2.50375136
28Macroorchidism (HP:0000053)2.50123581
29Abnormal platelet volume (HP:0011876)2.49066067
30Recurrent abscess formation (HP:0002722)2.48432037
31Increased IgE level (HP:0003212)2.47495861
32Petechiae (HP:0000967)2.44939717
33Increased mean platelet volume (HP:0011877)2.42189627
34Recurrent bronchitis (HP:0002837)2.41980624
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.38226457
36Acanthocytosis (HP:0001927)2.35992006
37Abnormality of reticulocytes (HP:0004312)2.33856712
38Broad face (HP:0000283)2.31081672
39Cerebral aneurysm (HP:0004944)2.28889584
40Abnormality of oral frenula (HP:0000190)2.28428127
41Hematochezia (HP:0002573)2.27289686
42T lymphocytopenia (HP:0005403)2.26852328
43Hyporeflexia of lower limbs (HP:0002600)2.25767535
44Cervical subluxation (HP:0003308)2.25623382
45Purpura (HP:0000979)2.25590988
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25279896
47Cellulitis (HP:0100658)2.24454661
48Gingival bleeding (HP:0000225)2.24408342
49Elevated erythrocyte sedimentation rate (HP:0003565)2.24382919
50Postural instability (HP:0002172)2.21945949
51Increased cerebral lipofuscin (HP:0011813)2.21895741
52Premature rupture of membranes (HP:0001788)2.21740213
53Abnormal hemoglobin (HP:0011902)2.20911768
54Ureteral stenosis (HP:0000071)2.20117489
55Abnormality of T cell number (HP:0011839)2.19429060
56Asymmetric septal hypertrophy (HP:0001670)2.17350312
57Supranuclear gaze palsy (HP:0000605)2.12945617
58Sensorimotor neuropathy (HP:0007141)2.12458778
59Emphysema (HP:0002097)2.11779723
60Exercise-induced myalgia (HP:0003738)2.09532187
61Prolonged bleeding time (HP:0003010)2.09056163
62Cupped ribs (HP:0000887)2.09012627
63Dysostosis multiplex (HP:0000943)2.08405951
64Ureteral obstruction (HP:0006000)2.07387049
65Gastrointestinal stroma tumor (HP:0100723)2.06728006
66Fatigue (HP:0012378)2.06142283
67Hyperthyroidism (HP:0000836)2.05373748
68Truncus arteriosus (HP:0001660)2.04821723
69Verrucae (HP:0200043)2.04052854
70Papilloma (HP:0012740)2.04052854
71Vasculitis (HP:0002633)2.03797106
72Upper limb muscle weakness (HP:0003484)2.03548725
73Frequent falls (HP:0002359)2.03058530
74Spontaneous hematomas (HP:0007420)2.02499434
75Chest pain (HP:0100749)2.02432985
76Myocardial infarction (HP:0001658)2.01999122
77Flat acetabular roof (HP:0003180)1.99082706
78Upper limb amyotrophy (HP:0009129)1.98604496
79Distal upper limb amyotrophy (HP:0007149)1.98604496
80Aneurysm (HP:0002617)1.98184685
81Right ventricular cardiomyopathy (HP:0011663)1.97835293
82Increased serum ferritin (HP:0003281)1.97437867
83Bowel incontinence (HP:0002607)1.96504306
84Interstitial pulmonary disease (HP:0006530)1.94629445
85Dysmetric saccades (HP:0000641)1.94120691
86Recurrent skin infections (HP:0001581)1.93357764
87Chronic mucocutaneous candidiasis (HP:0002728)1.92739648
88Recurrent cutaneous fungal infections (HP:0011370)1.92739648
89Abnormal large intestine physiology (HP:0012700)1.91375372
90Dilatation of the ascending aorta (HP:0005111)1.90875236
91Facial diplegia (HP:0001349)1.90348036
92Ileus (HP:0002595)1.90005352
93Vertebral compression fractures (HP:0002953)1.89790808
94Abnormal gallbladder morphology (HP:0012437)1.89488591
95Chronic obstructive pulmonary disease (HP:0006510)1.88882771
96Obstructive lung disease (HP:0006536)1.88882771
97Agammaglobulinemia (HP:0004432)1.88861569
98Arterial thrombosis (HP:0004420)1.88773937
99Gingivitis (HP:0000230)1.88084229
100Epistaxis (HP:0000421)1.87665510
101Hemorrhage of the eye (HP:0011885)1.87565905
102Myositis (HP:0100614)1.87134477
103Obstructive sleep apnea (HP:0002870)1.86490912
104Broad metatarsal (HP:0001783)1.85963548
105Difficulty running (HP:0009046)1.84791641
106Hypochromic anemia (HP:0001931)1.82884265
107Impaired platelet aggregation (HP:0003540)1.82254528
108Abnormal platelet function (HP:0011869)1.82254528
109Recurrent gram-negative bacterial infections (HP:0005420)1.82074637
110Stomatitis (HP:0010280)1.81397624
111Lower limb amyotrophy (HP:0007210)1.80962447
112Hypoparathyroidism (HP:0000829)1.80451834
113Abnormality of nail color (HP:0100643)1.79912293
114Cholelithiasis (HP:0001081)1.79599472
115Distal lower limb amyotrophy (HP:0008944)1.79473915
116Periodontitis (HP:0000704)1.78957575
117Long toe (HP:0010511)1.76991017
118Sudden death (HP:0001699)1.76893360
119Decreased motor nerve conduction velocity (HP:0003431)1.76195741
120Mediastinal lymphadenopathy (HP:0100721)1.75812702
121Segmental peripheral demyelination/remyelination (HP:0003481)1.75609665
122Blue sclerae (HP:0000592)1.75233968
123Abnormality of iron homeostasis (HP:0011031)1.74252114
124Gastrointestinal infarctions (HP:0005244)1.73932970
125Loss of speech (HP:0002371)1.73518718
126Striae distensae (HP:0001065)1.72970937
127Abnormality of the thoracic spine (HP:0100711)1.72598071
128Abnormality of T cells (HP:0002843)1.72426293
129Easy fatigability (HP:0003388)1.71369498
130Biconcave vertebral bodies (HP:0004586)1.70203360
131Long palpebral fissure (HP:0000637)1.69834708
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.69233601
133Ulnar bowing (HP:0003031)1.68602434
134Restrictive lung disease (HP:0002091)1.68376777
135Bruising susceptibility (HP:0000978)1.68350093
136Arterial tortuosity (HP:0005116)1.67666027
137Atelectasis (HP:0100750)1.67580424
138Autoimmune hemolytic anemia (HP:0001890)1.66217454
139Chronic diarrhea (HP:0002028)1.65798029
140Hypertriglyceridemia (HP:0002155)1.65699581
141Vacuolated lymphocytes (HP:0001922)1.65169242
142Abnormality of the gallbladder (HP:0005264)1.65149616
143Abnormality of macrophages (HP:0004311)1.62795798
144Insomnia (HP:0100785)1.62545638
145Thin bony cortex (HP:0002753)1.62114790
146Seborrheic dermatitis (HP:0001051)1.61907496
147Venous abnormality (HP:0002624)1.61861868
148Ovoid vertebral bodies (HP:0003300)1.61855207
149Meningitis (HP:0001287)1.61294420
150J-shaped sella turcica (HP:0002680)1.60953761
151Fragile skin (HP:0001030)1.60941821
152Gastrointestinal dysmotility (HP:0002579)1.60485812
153Chronic sinusitis (HP:0011109)1.59799706
154Sparse lateral eyebrow (HP:0005338)1.58636320
155Metaphyseal cupping (HP:0003021)1.58079132
156Mucopolysacchariduria (HP:0008155)1.58035257
157Urinary glycosaminoglycan excretion (HP:0003541)1.58035257
158Panhypogammaglobulinemia (HP:0003139)1.57782132
159Increased connective tissue (HP:0009025)1.57110781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK13.94772719
2IKBKE3.15248401
3ERN12.79246814
4MAP4K12.75527076
5PRPF4B2.72026905
6TRIB32.67989063
7PKN22.20034419
8TTN2.17377704
9TYK22.07535806
10GRK62.06905584
11MAP3K102.05737162
12EEF2K1.94606290
13MAP3K131.92948412
14RIPK41.91707817
15SIK21.88544855
16JAK11.85484081
17MAP3K141.76186787
18JAK31.75868379
19RIPK11.69709095
20SMG11.69677653
21FGFR41.66600139
22EIF2AK11.62231723
23PTK61.55544702
24EPHB11.55500549
25DMPK1.54957994
26MAP3K71.54138537
27TAOK11.50896422
28IKBKB1.45523487
29PDPK11.41642309
30TAOK31.39577055
31MAP3K31.38121108
32TGFBR21.36445723
33PDK11.35531403
34CAMK1G1.31910252
35TAOK21.28263804
36FGFR31.27427644
37BLK1.23202819
38KIT1.22750891
39MAP3K61.20688023
40SIK11.18909292
41ZAP701.17945060
42CAMK1D1.15769393
43SYK1.14166058
44JAK21.08791783
45CSK1.06388831
46HCK1.04233864
47EPHA20.98405736
48STK100.97863793
49SGK30.93526964
50KSR20.88606115
51LRRK20.86176719
52PRKCH0.84620925
53MARK20.83653504
54MAP3K80.83271879
55ITK0.82739918
56FES0.81723116
57MST40.78292595
58DDR20.76922038
59NME20.76615225
60SIK30.76355969
61PIK3CA0.76308721
62PAK40.76227873
63MAP2K30.75753155
64TYRO30.75498314
65LCK0.75033492
66PIM10.74744403
67PRKD10.74641070
68BMPR20.74395872
69MET0.74187259
70RET0.73796676
71BTK0.73633826
72CDK90.72883168
73PRKG20.72479926
74CDK120.72469298
75MAPK120.70195463
76DAPK20.70165980
77LMTK20.68894470
78KSR10.68339004
79MAP3K110.66000468
80CHUK0.65476068
81MAPK110.65473727
82TXK0.65331426
83CLK10.65275311
84PRKAA20.64542385
85RPS6KL10.63241112
86RPS6KC10.63241112
87BMX0.62592463
88MAP3K20.62109111
89HIPK20.61340020
90CDK60.60743530
91STK40.60567314
92MATK0.60073296
93PKN10.59951679
94RPS6KA20.56793740
95PRKCQ0.56580758
96MAP3K90.55608488
97PDGFRB0.55184698
98IRAK20.55082902
99MAP3K10.54902325
100NTRK10.54410506
101CDK40.54066215
102PRKD20.50548876
103RAF10.50388390
104ICK0.49578465
105CDC42BPA0.49536647
106LATS20.48574599
107PTK2B0.47948962
108MAP2K60.46396256
109MST1R0.46394461
110STK110.46117491
111IRAK30.45372494
112RPS6KA60.45294028
113YES10.45240911
114NEK20.45199802
115CSF1R0.45037455
116WNK10.43634186
117DYRK1B0.43177807
118PTK20.43128525
119FYN0.43052451
120MOS0.42899100
121CAMKK10.42171924
122EPHA30.41845644
123MAP2K10.41345356
124MTOR0.40895583
125MELK0.40170232
126MARK30.39565602
127TRPM70.39407223
128FGR0.38860925
129PDGFRA0.38633055
130IRAK40.38519290
131STK380.38512541
132IGF1R0.35849381
133SRC0.35347025

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.78224108
2Bladder cancer_Homo sapiens_hsa052191.77097624
3Osteoclast differentiation_Homo sapiens_hsa043801.71715657
4Primary immunodeficiency_Homo sapiens_hsa053401.65154900
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54839649
6Measles_Homo sapiens_hsa051621.54366677
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53424899
8Leishmaniasis_Homo sapiens_hsa051401.51693449
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50358941
10Renal cell carcinoma_Homo sapiens_hsa052111.42926726
11Type II diabetes mellitus_Homo sapiens_hsa049301.32822395
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.32544418
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30406261
14Influenza A_Homo sapiens_hsa051641.30103461
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29364207
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.28421943
17Caffeine metabolism_Homo sapiens_hsa002321.26693210
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26617659
19Small cell lung cancer_Homo sapiens_hsa052221.25122068
20ABC transporters_Homo sapiens_hsa020101.24650850
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.23776849
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.23100392
23Toxoplasmosis_Homo sapiens_hsa051451.22783492
24Insulin resistance_Homo sapiens_hsa049311.21112786
25T cell receptor signaling pathway_Homo sapiens_hsa046601.17905079
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16253754
27Thyroid cancer_Homo sapiens_hsa052161.15777120
28Pertussis_Homo sapiens_hsa051331.14903902
29Staphylococcus aureus infection_Homo sapiens_hsa051501.13156461
30Fructose and mannose metabolism_Homo sapiens_hsa000511.13131507
31Chemokine signaling pathway_Homo sapiens_hsa040621.12399217
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12091963
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.11803472
34Platelet activation_Homo sapiens_hsa046111.11757467
35Endometrial cancer_Homo sapiens_hsa052131.11700185
36Hepatitis C_Homo sapiens_hsa051601.10473388
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09003558
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07619676
39Pancreatic cancer_Homo sapiens_hsa052121.07475026
40Chronic myeloid leukemia_Homo sapiens_hsa052201.07410306
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06436003
42Hematopoietic cell lineage_Homo sapiens_hsa046401.04983853
43ErbB signaling pathway_Homo sapiens_hsa040121.04476680
44Acute myeloid leukemia_Homo sapiens_hsa052211.02743360
45TNF signaling pathway_Homo sapiens_hsa046681.01724497
46Tuberculosis_Homo sapiens_hsa051521.01692310
47Prostate cancer_Homo sapiens_hsa052151.00724110
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.00043290
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95726651
50MicroRNAs in cancer_Homo sapiens_hsa052060.95642212
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95380151
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95109860
53Shigellosis_Homo sapiens_hsa051310.94652568
54VEGF signaling pathway_Homo sapiens_hsa043700.93980932
55Prion diseases_Homo sapiens_hsa050200.91911853
56Viral carcinogenesis_Homo sapiens_hsa052030.91502164
57Bile secretion_Homo sapiens_hsa049760.91321126
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90227154
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.89693620
60Dorso-ventral axis formation_Homo sapiens_hsa043200.88596316
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87908966
62Salivary secretion_Homo sapiens_hsa049700.87383708
63Hepatitis B_Homo sapiens_hsa051610.84898100
64Non-small cell lung cancer_Homo sapiens_hsa052230.84386528
65GnRH signaling pathway_Homo sapiens_hsa049120.83986752
66Lysosome_Homo sapiens_hsa041420.82809746
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82082605
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81949644
69Viral myocarditis_Homo sapiens_hsa054160.81486568
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.81390512
71Lysine degradation_Homo sapiens_hsa003100.80614287
72Gastric acid secretion_Homo sapiens_hsa049710.79715430
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.78799705
74Renin secretion_Homo sapiens_hsa049240.78433128
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78420908
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78248989
77Malaria_Homo sapiens_hsa051440.77817623
78Dilated cardiomyopathy_Homo sapiens_hsa054140.77503038
79Mineral absorption_Homo sapiens_hsa049780.76009381
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75075829
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75014187
82Salmonella infection_Homo sapiens_hsa051320.73399118
83Prolactin signaling pathway_Homo sapiens_hsa049170.73261550
84Choline metabolism in cancer_Homo sapiens_hsa052310.73095863
85Pancreatic secretion_Homo sapiens_hsa049720.71875557
86ECM-receptor interaction_Homo sapiens_hsa045120.71078903
87Apoptosis_Homo sapiens_hsa042100.70719311
88mTOR signaling pathway_Homo sapiens_hsa041500.70563193
89PPAR signaling pathway_Homo sapiens_hsa033200.70265164
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70072811
91Fat digestion and absorption_Homo sapiens_hsa049750.69605875
92HTLV-I infection_Homo sapiens_hsa051660.68752703
93Glycerolipid metabolism_Homo sapiens_hsa005610.67458970
94Antigen processing and presentation_Homo sapiens_hsa046120.67300850
95Amoebiasis_Homo sapiens_hsa051460.67270505
96Endocytosis_Homo sapiens_hsa041440.66792326
97Legionellosis_Homo sapiens_hsa051340.66710322
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.66037333
99Herpes simplex infection_Homo sapiens_hsa051680.65184342
100Pentose phosphate pathway_Homo sapiens_hsa000300.65104495
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65083129
102HIF-1 signaling pathway_Homo sapiens_hsa040660.64745972
103Inositol phosphate metabolism_Homo sapiens_hsa005620.64635198
104Graft-versus-host disease_Homo sapiens_hsa053320.62753212
105Adherens junction_Homo sapiens_hsa045200.62017123
106Insulin signaling pathway_Homo sapiens_hsa049100.61370366
107Galactose metabolism_Homo sapiens_hsa000520.61052870
108Glioma_Homo sapiens_hsa052140.61052542
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59693005
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59143454
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58986324
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58790100
113African trypanosomiasis_Homo sapiens_hsa051430.58633773
114Nitrogen metabolism_Homo sapiens_hsa009100.57450196
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56476487
116Other glycan degradation_Homo sapiens_hsa005110.56070479
117FoxO signaling pathway_Homo sapiens_hsa040680.55204539
118Focal adhesion_Homo sapiens_hsa045100.54428419
119Estrogen signaling pathway_Homo sapiens_hsa049150.54266425
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53672156
121Long-term potentiation_Homo sapiens_hsa047200.53475036
122Oxytocin signaling pathway_Homo sapiens_hsa049210.52409787
123Olfactory transduction_Homo sapiens_hsa047400.52205924
124AMPK signaling pathway_Homo sapiens_hsa041520.52191743
125Fatty acid degradation_Homo sapiens_hsa000710.51837915
126Notch signaling pathway_Homo sapiens_hsa043300.51607562
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51532932
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51048923
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50650353
130Colorectal cancer_Homo sapiens_hsa052100.50137894
131Epstein-Barr virus infection_Homo sapiens_hsa051690.49316294
132Proteoglycans in cancer_Homo sapiens_hsa052050.48685609
133Pathways in cancer_Homo sapiens_hsa052000.46939345
134MAPK signaling pathway_Homo sapiens_hsa040100.46532726

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