GTPBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.44285039
2DNA replication initiation (GO:0006270)4.41742261
3maturation of SSU-rRNA (GO:0030490)4.41385136
4translational termination (GO:0006415)4.37432832
5regulation of nuclear cell cycle DNA replication (GO:0033262)4.21306458
6mitotic metaphase plate congression (GO:0007080)4.01290543
7behavioral response to nicotine (GO:0035095)4.00752903
8DNA strand elongation involved in DNA replication (GO:0006271)4.00284742
9telomere maintenance via semi-conservative replication (GO:0032201)3.99640434
10protein K6-linked ubiquitination (GO:0085020)3.98654522
11DNA strand elongation (GO:0022616)3.88183892
12tRNA methylation (GO:0030488)3.86775609
13translational elongation (GO:0006414)3.80265435
14DNA strand renaturation (GO:0000733)3.78584540
15ribosomal large subunit biogenesis (GO:0042273)3.77826277
16ribosomal small subunit biogenesis (GO:0042274)3.69219576
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65356925
18ribonucleoprotein complex biogenesis (GO:0022613)3.63933789
19ribosome biogenesis (GO:0042254)3.61732161
20protein localization to kinetochore (GO:0034501)3.60047487
21telomere maintenance via telomere lengthening (GO:0010833)3.59541730
22cotranslational protein targeting to membrane (GO:0006613)3.59498441
23negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.57497736
24DNA replication checkpoint (GO:0000076)3.55607599
25rRNA modification (GO:0000154)3.55340772
26pseudouridine synthesis (GO:0001522)3.55258721
27kinetochore assembly (GO:0051382)3.54595380
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54134424
29protein targeting to ER (GO:0045047)3.53343415
30regulation of mitochondrial translation (GO:0070129)3.52500584
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.51066677
32UTP biosynthetic process (GO:0006228)3.50750220
33L-serine metabolic process (GO:0006563)3.49390062
34DNA damage response, detection of DNA damage (GO:0042769)3.48535398
35metaphase plate congression (GO:0051310)3.48212809
36cellular component biogenesis (GO:0044085)3.46834014
37single strand break repair (GO:0000012)3.43476926
38viral life cycle (GO:0019058)3.42687543
39protein complex biogenesis (GO:0070271)3.41705500
40establishment of integrated proviral latency (GO:0075713)3.40795585
41rRNA processing (GO:0006364)3.38426306
42termination of RNA polymerase I transcription (GO:0006363)3.38104109
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38090864
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.38090864
45NADH dehydrogenase complex assembly (GO:0010257)3.38090864
46transcription elongation from RNA polymerase I promoter (GO:0006362)3.37866639
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37742482
48kinetochore organization (GO:0051383)3.35351214
49protein localization to endoplasmic reticulum (GO:0070972)3.33977406
50UTP metabolic process (GO:0046051)3.33808260
51mitochondrial respiratory chain complex assembly (GO:0033108)3.32124760
52pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31121975
53rRNA metabolic process (GO:0016072)3.30260882
54negative regulation of DNA-templated transcription, elongation (GO:0032785)3.30026568
55cellular protein complex disassembly (GO:0043624)3.29257924
56pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28650244
57IMP biosynthetic process (GO:0006188)3.28506289
58DNA replication-dependent nucleosome assembly (GO:0006335)3.27743572
59DNA replication-dependent nucleosome organization (GO:0034723)3.27743572
60telomere maintenance via recombination (GO:0000722)3.27336510
61spliceosomal snRNP assembly (GO:0000387)3.26713995
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.26391511
63GTP biosynthetic process (GO:0006183)3.23971051
64translational initiation (GO:0006413)3.22763046
65CENP-A containing nucleosome assembly (GO:0034080)3.21989523
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21921837
67pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.21727185
68transcription elongation from RNA polymerase III promoter (GO:0006385)3.21307486
69termination of RNA polymerase III transcription (GO:0006386)3.21307486
70rRNA methylation (GO:0031167)3.20968348
71regulation of development, heterochronic (GO:0040034)3.20499725
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19789035
73DNA unwinding involved in DNA replication (GO:0006268)3.19527406
74negative regulation of telomere maintenance (GO:0032205)3.19412997
75protein complex disassembly (GO:0043241)3.19329480
76mitotic recombination (GO:0006312)3.19059226
77regulation of posttranscriptional gene silencing (GO:0060147)3.18484410
78regulation of gene silencing by miRNA (GO:0060964)3.18484410
79regulation of gene silencing by RNA (GO:0060966)3.18484410
80heterochromatin organization (GO:0070828)3.17450858
81post-embryonic morphogenesis (GO:0009886)3.16088390
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.14884106
83regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14640502
84mitochondrial RNA metabolic process (GO:0000959)3.12551347
85pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.10771164
86chromatin remodeling at centromere (GO:0031055)3.08747224
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05814750
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05814750
89regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05122961
90regulation of timing of cell differentiation (GO:0048505)3.03315634
91macromolecular complex disassembly (GO:0032984)3.02195548
92CTP biosynthetic process (GO:0006241)3.01117005
93CTP metabolic process (GO:0046036)3.01117005
94DNA ligation (GO:0006266)3.00890677
95folic acid-containing compound biosynthetic process (GO:0009396)3.00690903
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.00438790
97protein localization to chromosome, centromeric region (GO:0071459)3.00270768
98transcription-coupled nucleotide-excision repair (GO:0006283)2.98061653
99regulation of translational fidelity (GO:0006450)2.98060453
100histone H2B ubiquitination (GO:0033523)2.98047345
101DNA replication-independent nucleosome organization (GO:0034724)2.97648848
102DNA replication-independent nucleosome assembly (GO:0006336)2.97648848
103microtubule depolymerization (GO:0007019)2.96487108
104negative regulation of DNA recombination (GO:0045910)2.95740210
105* tRNA modification (GO:0006400)2.95492007
106* tRNA processing (GO:0008033)2.95485199
107establishment of chromosome localization (GO:0051303)2.94548822
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93473458
109transcription from RNA polymerase I promoter (GO:0006360)2.93258851
110regulation of helicase activity (GO:0051095)2.93149062
111base-excision repair, AP site formation (GO:0006285)2.91479525
112telomere maintenance via telomerase (GO:0007004)2.91245311
113* ncRNA processing (GO:0034470)2.89270829
114mitotic sister chromatid segregation (GO:0000070)2.89247103
115peptidyl-arginine omega-N-methylation (GO:0035247)2.88207799
116regulation of telomerase activity (GO:0051972)2.87910538
117iron-sulfur cluster assembly (GO:0016226)2.87177554
118metallo-sulfur cluster assembly (GO:0031163)2.87177554
119ncRNA 3-end processing (GO:0043628)2.87066669
120maturation of 5.8S rRNA (GO:0000460)2.86799671
121telomere organization (GO:0032200)2.86566636
122replication fork processing (GO:0031297)2.85472119
123RNA methylation (GO:0001510)2.85290389
124rRNA transcription (GO:0009303)2.85153355
125negative regulation of telomerase activity (GO:0051974)2.85040010
126transcription from mitochondrial promoter (GO:0006390)2.84689455
127protein neddylation (GO:0045116)2.84606759
128negative regulation of RNA splicing (GO:0033119)2.84423323
129telomere maintenance (GO:0000723)2.84267767
130respiratory chain complex IV assembly (GO:0008535)2.83480197
131translation (GO:0006412)2.81421403
132ATP synthesis coupled proton transport (GO:0015986)2.79687078
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.79687078
134transcription initiation from RNA polymerase I promoter (GO:0006361)2.79665384
135negative regulation of mRNA processing (GO:0050686)2.79342394
136* ncRNA metabolic process (GO:0034660)2.76859140
137chaperone-mediated protein transport (GO:0072321)2.75709119
138chromatin assembly (GO:0031497)2.75612073
139cytochrome complex assembly (GO:0017004)2.75407814
140histone arginine methylation (GO:0034969)2.75217091
141DNA-templated transcription, termination (GO:0006353)2.74791229
142ribosome assembly (GO:0042255)2.74063077
143ubiquinone biosynthetic process (GO:0006744)2.72733676
144* tRNA metabolic process (GO:0006399)2.71943543
145DNA replication (GO:0006260)2.71340361
146ribosomal small subunit assembly (GO:0000028)2.71321264
147pyrimidine nucleotide catabolic process (GO:0006244)2.71019799
148mesenchymal cell differentiation involved in renal system development (GO:2001012)2.70918645
149mesenchymal cell differentiation involved in kidney development (GO:0072161)2.70918645
150amino sugar catabolic process (GO:0046348)2.70853704
151establishment of protein localization to mitochondrial membrane (GO:0090151)2.70588250
152regulation of DNA-dependent DNA replication (GO:0090329)2.69467636
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69017020
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.69017020
155somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68236144
156isotype switching (GO:0045190)2.68236144
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68236144
158keratinocyte development (GO:0003334)2.67115106
159nuclear-transcribed mRNA catabolic process (GO:0000956)2.67021663
160establishment of viral latency (GO:0019043)2.66909974
161peptidyl-histidine modification (GO:0018202)2.66510518
162viral transcription (GO:0019083)2.66180781
163centriole assembly (GO:0098534)2.65691306
164mismatch repair (GO:0006298)2.65375025
165folic acid metabolic process (GO:0046655)2.62764260
166viral mRNA export from host cell nucleus (GO:0046784)2.62183964
167RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.58885758
168guanosine-containing compound biosynthetic process (GO:1901070)2.58170590
169mRNA catabolic process (GO:0006402)2.57993315
170cell proliferation in forebrain (GO:0021846)2.57655005
171protein-DNA complex disassembly (GO:0032986)2.55815112
172nucleosome disassembly (GO:0006337)2.55815112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04568079
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.78716964
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.47050285
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.89206435
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.88725451
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46396201
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37185239
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.35320364
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19655651
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12029511
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79567465
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78206348
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.77022342
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69720638
15* CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.68777963
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61558285
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.58687064
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.57388157
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.50318159
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34500917
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33238299
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.31356350
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20205312
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.13662774
25CIITA_25753668_ChIP-Seq_RAJI_Human2.09894876
26* FOXP3_21729870_ChIP-Seq_TREG_Human2.09579202
27VDR_23849224_ChIP-Seq_CD4+_Human2.03060768
28NOTCH1_21737748_ChIP-Seq_TLL_Human2.01724026
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01374223
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.97066838
31XRN2_22483619_ChIP-Seq_HELA_Human1.94722854
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93194676
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93194676
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93194676
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87078023
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86586455
37* TTF2_22483619_ChIP-Seq_HELA_Human1.86305285
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86144951
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82391887
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78440168
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73535689
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73275896
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.72069948
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71829520
45DCP1A_22483619_ChIP-Seq_HELA_Human1.70313049
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66575694
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60830305
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57647776
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53369370
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52828164
51GABP_19822575_ChIP-Seq_HepG2_Human1.52450159
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50803700
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.46408982
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45619043
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44320356
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43814759
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42423456
58* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40495348
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39691051
60P68_20966046_ChIP-Seq_HELA_Human1.39485138
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36792954
62* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34377695
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28103403
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26977272
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.26844976
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22942122
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22910095
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21574780
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21088648
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20927809
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.20222557
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18535140
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17868362
74ZNF274_21170338_ChIP-Seq_K562_Hela1.17161607
75PHF8_20622854_ChIP-Seq_HELA_Human1.16325288
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.15823656
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15089278
78IRF1_19129219_ChIP-ChIP_H3396_Human1.12583976
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12171252
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09647207
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09003826
82MYC_18940864_ChIP-ChIP_HL60_Human1.07025323
83ELK1_19687146_ChIP-ChIP_HELA_Human1.06451311
84MYC_22102868_ChIP-Seq_BL_Human1.04907174
85* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04788120
86E2F1_20622854_ChIP-Seq_HELA_Human1.04675504
87AR_21909140_ChIP-Seq_LNCAP_Human1.04482200
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04162222
89* YY1_22570637_ChIP-Seq_MALME-3M_Human1.01166585
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00878776
91VDR_21846776_ChIP-Seq_THP-1_Human1.00778705
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00738617
93TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99010246
94* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98719847
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98700966
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97871856
97BCL6_27268052_Chip-Seq_Bcells_Human0.97713965
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96767749
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96694954
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96685080
101ZNF263_19887448_ChIP-Seq_K562_Human0.96112673
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95935531
103LXR_22292898_ChIP-Seq_THP-1_Human0.95529531
104CTCF_27219007_Chip-Seq_Bcells_Human0.95069256
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91761840
106KDM5A_27292631_Chip-Seq_BREAST_Human0.91759585
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91632404
108* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91283412
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.91273222
110CTCF_20526341_ChIP-Seq_ESCs_Human0.90080629
111ERA_21632823_ChIP-Seq_H3396_Human0.89070980
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.88589182
113TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86871614
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86591892
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85469178
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85064321
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82570848
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81789472
119TFEB_21752829_ChIP-Seq_HELA_Human0.81744932
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81351118
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80146974
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79648294
123SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78671872
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77826949
125PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77451315
126* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77183465
127NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76055014
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76020309
129FOXP1_21924763_ChIP-Seq_HESCs_Human0.73318732
130* NANOG_16153702_ChIP-ChIP_HESCs_Human0.73091113
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72169753
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.71633115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.80981056
2MP0003111_abnormal_nucleus_morphology4.55249602
3MP0003693_abnormal_embryo_hatching4.43943218
4MP0008058_abnormal_DNA_repair4.09217349
5MP0010094_abnormal_chromosome_stability3.84448903
6MP0000566_synostosis3.55488269
7MP0002102_abnormal_ear_morphology3.04424966
8MP0003077_abnormal_cell_cycle3.00405890
9MP0002163_abnormal_gland_morphology2.98183865
10MP0004957_abnormal_blastocyst_morpholog2.78782595
11MP0003136_yellow_coat_color2.54651681
12MP0003941_abnormal_skin_development2.46010647
13MP0003123_paternal_imprinting2.43952806
14MP0008057_abnormal_DNA_replication2.40115665
15MP0002132_abnormal_respiratory_system2.18973789
16MP0004381_abnormal_hair_follicle2.18552618
17MP0008932_abnormal_embryonic_tissue2.10997180
18MP0004133_heterotaxia2.10350684
19MP0009379_abnormal_foot_pigmentation2.05525168
20MP0003122_maternal_imprinting2.05019657
21MP0003718_maternal_effect2.04354319
22MP0002396_abnormal_hematopoietic_system2.01362424
23MP0002234_abnormal_pharynx_morphology1.89576207
24MP0008007_abnormal_cellular_replicative1.89172646
25MP0003938_abnormal_ear_development1.87237539
26MP0005379_endocrine/exocrine_gland_phen1.86774216
27MP0003786_premature_aging1.85371726
28MP0001188_hyperpigmentation1.78948423
29MP0003787_abnormal_imprinting1.75288502
30MP0009333_abnormal_splenocyte_physiolog1.68661246
31MP0001529_abnormal_vocalization1.67282329
32MP0000631_abnormal_neuroendocrine_gland1.65109099
33MP0005075_abnormal_melanosome_morpholog1.61952688
34MP0000490_abnormal_crypts_of1.56655235
35MP0002249_abnormal_larynx_morphology1.47735001
36MP0002938_white_spotting1.44250161
37MP0000678_abnormal_parathyroid_gland1.43220309
38MP0005670_abnormal_white_adipose1.40875404
39MP0002277_abnormal_respiratory_mucosa1.39889305
40MP0006276_abnormal_autonomic_nervous1.38198902
41MP0000049_abnormal_middle_ear1.37184894
42MP0001986_abnormal_taste_sensitivity1.35689080
43MP0000778_abnormal_nervous_system1.34877830
44MP0010030_abnormal_orbit_morphology1.34633159
45MP0001502_abnormal_circadian_rhythm1.34080014
46MP0001346_abnormal_lacrimal_gland1.33559262
47MP0001348_abnormal_lacrimal_gland1.30246743
48MP0003942_abnormal_urinary_system1.29804371
49MP0000350_abnormal_cell_proliferation1.27636763
50MP0001293_anophthalmia1.25150135
51MP0003890_abnormal_embryonic-extraembry1.24307993
52MP0003763_abnormal_thymus_physiology1.23950717
53MP0000703_abnormal_thymus_morphology1.22002834
54MP0000313_abnormal_cell_death1.20167454
55MP0005389_reproductive_system_phenotype1.17711512
56MP0002085_abnormal_embryonic_tissue1.14849946
57MP0003878_abnormal_ear_physiology1.12465461
58MP0005377_hearing/vestibular/ear_phenot1.12465461
59MP0008260_abnormal_autophagy1.12455084
60MP0008877_abnormal_DNA_methylation1.12414116
61MP0004142_abnormal_muscle_tone1.07977588
62MP0005380_embryogenesis_phenotype1.06039545
63MP0001672_abnormal_embryogenesis/_devel1.06039545
64MP0008789_abnormal_olfactory_epithelium1.05376189
65MP0008995_early_reproductive_senescence1.04429839
66MP0001286_abnormal_eye_development1.04226534
67MP0004742_abnormal_vestibular_system1.03909383
68MP0003646_muscle_fatigue1.03799966
69MP0002751_abnormal_autonomic_nervous1.02727192
70MP0004147_increased_porphyrin_level1.02466481
71MP0006035_abnormal_mitochondrial_morpho1.01868510
72MP0001730_embryonic_growth_arrest1.00889863
73MP0001919_abnormal_reproductive_system1.00870599
74MP0002111_abnormal_tail_morphology0.99320995
75MP0003937_abnormal_limbs/digits/tail_de0.98025868
76MP0000372_irregular_coat_pigmentation0.97865544
77MP0003121_genomic_imprinting0.96687230
78MP0002557_abnormal_social/conspecific_i0.96611382
79MP0003567_abnormal_fetal_cardiomyocyte0.96434880
80MP0001145_abnormal_male_reproductive0.95425938
81MP0002822_catalepsy0.94580630
82MP0005220_abnormal_exocrine_pancreas0.93548754
83MP0006072_abnormal_retinal_apoptosis0.93165858
84MP0005257_abnormal_intraocular_pressure0.92565800
85MP0005423_abnormal_somatic_nervous0.92370245
86MP0001905_abnormal_dopamine_level0.91898426
87MP0001968_abnormal_touch/_nociception0.91874803
88MP0005551_abnormal_eye_electrophysiolog0.91599773
89MP0000955_abnormal_spinal_cord0.91213110
90MP0005394_taste/olfaction_phenotype0.89809121
91MP0005499_abnormal_olfactory_system0.89809121
92MP0002080_prenatal_lethality0.89746162
93MP0003315_abnormal_perineum_morphology0.89523000
94MP0002184_abnormal_innervation0.89187868
95MP0002733_abnormal_thermal_nociception0.87719097
96MP0002152_abnormal_brain_morphology0.87498677
97MP0001186_pigmentation_phenotype0.87288130
98MP0002075_abnormal_coat/hair_pigmentati0.87144598
99MP0002084_abnormal_developmental_patter0.85998047
100MP0005195_abnormal_posterior_eye0.85571971
101MP0000653_abnormal_sex_gland0.85217142
102MP0001697_abnormal_embryo_size0.83625108
103MP0003283_abnormal_digestive_organ0.82669032
104MP0003119_abnormal_digestive_system0.81384954
105MP0001727_abnormal_embryo_implantation0.81126177
106MP0000462_abnormal_digestive_system0.80615569
107MP0000432_abnormal_head_morphology0.79915623
108MP0002722_abnormal_immune_system0.79865247
109MP0001929_abnormal_gametogenesis0.79108158
110MP0003698_abnormal_male_reproductive0.78588759
111MP0000428_abnormal_craniofacial_morphol0.78167701
112MP0005646_abnormal_pituitary_gland0.78151409
113MP0003011_delayed_dark_adaptation0.77935366
114MP0002697_abnormal_eye_size0.77580397
115MP0002019_abnormal_tumor_incidence0.77493802
116MP0002177_abnormal_outer_ear0.77199319
117MP0001270_distended_abdomen0.76700933
118MP0004197_abnormal_fetal_growth/weight/0.75390767
119MP0000470_abnormal_stomach_morphology0.74590965
120MP0000026_abnormal_inner_ear0.73933836
121MP0003861_abnormal_nervous_system0.72864170
122MP0002233_abnormal_nose_morphology0.72493351
123MP0003385_abnormal_body_wall0.72298071
124MP0002882_abnormal_neuron_morphology0.72148493
125MP0002837_dystrophic_cardiac_calcinosis0.71483436
126MP0001661_extended_life_span0.71178821
127MP0000015_abnormal_ear_pigmentation0.70795410
128MP0000467_abnormal_esophagus_morphology0.70591665
129MP0010307_abnormal_tumor_latency0.70007947
130MP0000858_altered_metastatic_potential0.69690801
131MP0002398_abnormal_bone_marrow0.69299373
132MP0005451_abnormal_body_composition0.68291322
133MP0002114_abnormal_axial_skeleton0.68262562
134MP0000689_abnormal_spleen_morphology0.68197460
135MP0002210_abnormal_sex_determination0.67989013
136MP0005645_abnormal_hypothalamus_physiol0.65818540
137MP0005174_abnormal_tail_pigmentation0.65076936
138MP0002116_abnormal_craniofacial_bone0.64905211
139MP0003984_embryonic_growth_retardation0.64134940
140MP0002160_abnormal_reproductive_system0.63345304
141MP0002086_abnormal_extraembryonic_tissu0.62718856
142MP0000358_abnormal_cell_content/0.62640601
143MP0002653_abnormal_ependyma_morphology0.62281372
144MP0005501_abnormal_skin_physiology0.61603521
145MP0002752_abnormal_somatic_nervous0.61065679
146MP0002088_abnormal_embryonic_growth/wei0.60607287
147MP0003755_abnormal_palate_morphology0.60164670
148MP0002638_abnormal_pupillary_reflex0.59939063
149MP0001485_abnormal_pinna_reflex0.59295739

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.89681029
2Chromsome breakage (HP:0040012)6.03775860
3Duplicated collecting system (HP:0000081)5.75046233
4Reticulocytopenia (HP:0001896)4.92033108
5Abnormality of the renal collecting system (HP:0004742)4.84570357
6Abnormality of DNA repair (HP:0003254)4.06316685
7Abnormality of the preputium (HP:0100587)3.95599206
8Birth length less than 3rd percentile (HP:0003561)3.84663957
9Meckel diverticulum (HP:0002245)3.72913033
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.59052184
11Selective tooth agenesis (HP:0001592)3.52253941
12Abnormality of chromosome stability (HP:0003220)3.51065291
13Abnormality of the ileum (HP:0001549)3.50085757
14Absent radius (HP:0003974)3.46825271
15Upper limb muscle weakness (HP:0003484)3.44425275
16Duplication of thumb phalanx (HP:0009942)3.30732257
17Absent forearm bone (HP:0003953)3.23654264
18Aplasia involving forearm bones (HP:0009822)3.23654264
19Breast hypoplasia (HP:0003187)3.09739498
20Absent thumb (HP:0009777)3.06996457
21Ectopic kidney (HP:0000086)3.04028568
22Septo-optic dysplasia (HP:0100842)3.01912858
23Abnormal number of incisors (HP:0011064)2.93040376
24Bone marrow hypocellularity (HP:0005528)2.91124434
25Horseshoe kidney (HP:0000085)2.85067121
26Squamous cell carcinoma (HP:0002860)2.75923123
27Bile duct proliferation (HP:0001408)2.71461618
28Abnormal biliary tract physiology (HP:0012439)2.71461618
29Premature graying of hair (HP:0002216)2.69422756
30Abnormality of cells of the erythroid lineage (HP:0012130)2.65164666
31Pancreatic fibrosis (HP:0100732)2.64423975
32Ureteral duplication (HP:0000073)2.63490365
33Triphalangeal thumb (HP:0001199)2.62810678
34Type II lissencephaly (HP:0007260)2.61196723
35Supernumerary spleens (HP:0009799)2.60618037
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59965917
37Pallor (HP:0000980)2.59632478
38Duodenal stenosis (HP:0100867)2.57686715
39Small intestinal stenosis (HP:0012848)2.57686715
40Abnormal number of erythroid precursors (HP:0012131)2.54496720
41Mitochondrial inheritance (HP:0001427)2.51542737
42Pendular nystagmus (HP:0012043)2.50913701
43Neoplasm of the adrenal cortex (HP:0100641)2.46653170
44Hepatocellular necrosis (HP:0001404)2.46152269
45Lipid accumulation in hepatocytes (HP:0006561)2.43587733
46Abnormal mitochondria in muscle tissue (HP:0008316)2.42626840
47Impulsivity (HP:0100710)2.40019426
48Sclerocornea (HP:0000647)2.39609940
49Acute necrotizing encephalopathy (HP:0006965)2.39234494
50Clubbing of toes (HP:0100760)2.38341772
51Increased CSF lactate (HP:0002490)2.37463453
52Patellar aplasia (HP:0006443)2.37179079
53Pancreatic cysts (HP:0001737)2.36986539
54Molar tooth sign on MRI (HP:0002419)2.35895683
55Abnormality of midbrain morphology (HP:0002418)2.35895683
56Asplenia (HP:0001746)2.34504129
57Short thumb (HP:0009778)2.33620360
58Abnormality of pyrimidine metabolism (HP:0004353)2.33338290
59Abnormality of the carotid arteries (HP:0005344)2.33167424
60Rough bone trabeculation (HP:0100670)2.33134938
61Hypoplasia of the pons (HP:0012110)2.30039662
62Nephroblastoma (Wilms tumor) (HP:0002667)2.27236624
63Slender long bone (HP:0003100)2.27131898
64Abnormality of the labia minora (HP:0012880)2.25639584
65Hepatic necrosis (HP:0002605)2.23133721
66Oral leukoplakia (HP:0002745)2.21601319
67Myelodysplasia (HP:0002863)2.21350707
68Facial cleft (HP:0002006)2.20250393
69Abnormal sex determination (HP:0012244)2.20141299
70Sex reversal (HP:0012245)2.20141299
71Retinal dysplasia (HP:0007973)2.19958367
72Increased hepatocellular lipid droplets (HP:0006565)2.19403397
73Acute encephalopathy (HP:0006846)2.18990545
74Renal agenesis (HP:0000104)2.18844053
75Sloping forehead (HP:0000340)2.18305019
76Abnormality of the duodenum (HP:0002246)2.17541193
77Aplasia/Hypoplasia of the spleen (HP:0010451)2.16249580
78Colon cancer (HP:0003003)2.14336142
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13655116
80Aplasia/Hypoplasia of the patella (HP:0006498)2.12783964
81Neoplasm of the pancreas (HP:0002894)2.12576654
82Nephronophthisis (HP:0000090)2.12445056
83Increased serum lactate (HP:0002151)2.12314832
84Pancytopenia (HP:0001876)2.10896924
85Abnormality of alanine metabolism (HP:0010916)2.10218900
86Hyperalaninemia (HP:0003348)2.10218900
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10218900
88Abnormality of the pons (HP:0007361)2.08979017
89Absent septum pellucidum (HP:0001331)2.08161800
90Tracheoesophageal fistula (HP:0002575)2.07700446
91Abnormality of the aortic arch (HP:0012303)2.06728151
92Hyperthyroidism (HP:0000836)2.06668808
93Abnormality of cochlea (HP:0000375)2.05314012
94Optic nerve coloboma (HP:0000588)2.04959948
95Embryonal renal neoplasm (HP:0011794)2.04776784
96Cerebral hypomyelination (HP:0006808)2.02096454
973-Methylglutaconic aciduria (HP:0003535)2.00474987
98Diastasis recti (HP:0001540)2.00392253
99Cerebellar dysplasia (HP:0007033)1.99088753
100Abnormality of the septum pellucidum (HP:0007375)1.97709296
101Lissencephaly (HP:0001339)1.97419727
102Poikiloderma (HP:0001029)1.96963395
103Severe muscular hypotonia (HP:0006829)1.96247192
104Microvesicular hepatic steatosis (HP:0001414)1.95294338
105Enlarged kidneys (HP:0000105)1.94170062
106Increased intramyocellular lipid droplets (HP:0012240)1.93499454
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93431942
108Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93431942
109Increased muscle lipid content (HP:0009058)1.90261941
110Prolonged neonatal jaundice (HP:0006579)1.89125211
111Abnormal rod and cone electroretinograms (HP:0008323)1.88597491
112Abnormality of the antihelix (HP:0009738)1.88596442
113Medulloblastoma (HP:0002885)1.88526326
114Macrocytic anemia (HP:0001972)1.86849298
115Panhypogammaglobulinemia (HP:0003139)1.86419607
116True hermaphroditism (HP:0010459)1.86147027
117Progressive external ophthalmoplegia (HP:0000590)1.85534235
118Lymphoma (HP:0002665)1.85462419
119Cystic liver disease (HP:0006706)1.85062327
120Preaxial hand polydactyly (HP:0001177)1.84641266
121Medial flaring of the eyebrow (HP:0010747)1.84459293
122Ependymoma (HP:0002888)1.83951471
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83498908
124Optic nerve hypoplasia (HP:0000609)1.83462107
125Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82497293
126Abnormality of abdominal situs (HP:0011620)1.82496729
127Abdominal situs inversus (HP:0003363)1.82496729
128Lactic acidosis (HP:0003128)1.81825645
129Aplasia cutis congenita (HP:0001057)1.81673594
130Abnormal delayed hypersensitivity skin test (HP:0002963)1.81568606
131Hypoplasia of the radius (HP:0002984)1.80952291
132Truncus arteriosus (HP:0001660)1.80718414
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80304563
134Abnormality of homocysteine metabolism (HP:0010919)1.79900187
135Homocystinuria (HP:0002156)1.79900187
136Adrenal hypoplasia (HP:0000835)1.78420677
137Deep palmar crease (HP:0006191)1.78131637
138Abnormality of the parathyroid morphology (HP:0011766)1.77059387
139Anophthalmia (HP:0000528)1.76608079
140Leukopenia (HP:0001882)1.76442915
141Cellular immunodeficiency (HP:0005374)1.76240690
142Supernumerary bones of the axial skeleton (HP:0009144)1.76010830
143Microretrognathia (HP:0000308)1.75382196
144Anencephaly (HP:0002323)1.75131756
145Neoplasm of the oral cavity (HP:0100649)1.73192228
146High anterior hairline (HP:0009890)1.72445189
147Prominent nose (HP:0000448)1.71311460
148Concave nail (HP:0001598)1.70792801
149Hypergonadotropic hypogonadism (HP:0000815)1.70109610
150Abnormality of reticulocytes (HP:0004312)1.69319816
151Abnormal lung lobation (HP:0002101)1.68996542
152Renal Fanconi syndrome (HP:0001994)1.68798283
153Rib fusion (HP:0000902)1.68187878
154Abnormality of the renal medulla (HP:0100957)1.67216235
155High pitched voice (HP:0001620)1.64746306
156Supernumerary ribs (HP:0005815)1.64099500
157Congenital stationary night blindness (HP:0007642)1.63096339
158IgM deficiency (HP:0002850)1.62812528
15911 pairs of ribs (HP:0000878)1.62223323
160Osteomalacia (HP:0002749)1.60961535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.08747496
2STK163.85942073
3BLK3.84174274
4VRK23.82510351
5TTK3.41777939
6TLK13.01279260
7ZAK2.93599873
8WNK42.84306623
9SRPK12.84181877
10MKNK22.79937867
11CASK2.75854971
12WEE12.22603047
13CDC72.11021709
14SMG12.10734232
15NME22.07640623
16NEK21.98905205
17CDK191.98398531
18CDK71.93002825
19EPHA21.89678425
20MKNK11.81093677
21ICK1.68799614
22MAP4K21.68637728
23GRK11.68005018
24IRAK31.65706695
25EIF2AK21.65463177
26PLK11.64954974
27ATR1.54848507
28BMPR1B1.53348603
29CDK41.50432694
30DYRK31.45585623
31NME11.42918215
32YES11.36890568
33CAMK1D1.34095278
34VRK11.33881168
35PLK41.30200145
36MAP3K101.29795558
37MAP3K111.28793864
38NEK61.28544280
39IRAK41.28224846
40CSNK1G31.26610459
41AURKA1.24819489
42AURKB1.18196554
43FLT31.16321180
44PIM21.15898705
45SIK21.15647132
46CAMK1G1.13792803
47BRAF1.13316219
48RPS6KB21.13298738
49TAF11.13136984
50IRAK11.11900819
51STK41.11643189
52BRD41.11269723
53PRKD21.06748079
54CDK121.05604385
55EIF2AK11.05586125
56ARAF1.05487190
57IRAK21.05265582
58BRSK11.05131862
59TSSK61.05017502
60CHEK11.02735495
61CHEK21.00486706
62STK38L0.99359827
63MAP3K90.95848290
64PRKCI0.93955044
65PASK0.93040624
66CSNK1G10.90871245
67MAP3K40.90398305
68EIF2AK30.88791367
69TRIM280.87246534
70CSNK1G20.86917366
71PHKG10.86471043
72PHKG20.86471043
73TESK20.85082012
74MAP3K80.84588949
75EEF2K0.84387951
76ADRBK20.80722229
77CLK10.80313919
78MAP4K10.80260839
79ALK0.77119477
80RPS6KA50.76734921
81TRIB30.75606346
82TNIK0.75276300
83ATM0.75072727
84FES0.74768126
85PRKCG0.74101517
86STK100.72154523
87PINK10.71645796
88CDK80.70274448
89DYRK20.68203197
90CDK20.67841664
91MAP2K20.67416019
92INSRR0.65756485
93MAPK130.65500038
94NTRK20.65298697
95CDK30.64224699
96FRK0.63613886
97KDR0.63335957
98TYRO30.62006787
99CAMK40.61997813
100MAPKAPK50.61948208
101MARK20.61320541
102CDK10.60767534
103TNK20.60099283
104MAP2K60.59467975
105MAPK150.58970399
106STK390.58944632
107STK110.58397153
108RPS6KA60.57930128
109AKT20.57011687
110MAP2K40.56861897
111TXK0.53892399
112CAMK10.51952171
113CAMKK10.51801633
114PLK30.51776450
115PAK10.50859090
116PRKD30.50486203
117NEK10.49971082
118NLK0.49870516
119CSNK2A20.48641766
120MAPK110.47832859
121PNCK0.47034292
122NUAK10.46256779
123WNK30.46229807
124PRKAA10.45556428
125RPS6KA40.45441708
126PIM10.45285251
127BCKDK0.44352312
128LYN0.44264816
129IKBKB0.42949189
130CSNK1A10.42169784
131CDK90.41853541
132MAP3K140.40741297
133CSNK2A10.40637022
134BTK0.39647993
135CSNK1E0.39363323
136PRKDC0.39295016
137CSNK1A1L0.37790184
138KIT0.37135976
139AKT10.36533481
140JAK30.36246549
141AKT30.34556884
142HCK0.33227513
143PAK20.33152756
144GSK3B0.30502987
145MAPK140.30167180
146MAP2K70.29775655
147LCK0.29336768
148PKN10.28844454

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11580418
2Mismatch repair_Homo sapiens_hsa034303.82523811
3Fanconi anemia pathway_Homo sapiens_hsa034603.74403067
4Homologous recombination_Homo sapiens_hsa034403.67047557
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40847099
6RNA polymerase_Homo sapiens_hsa030203.39120957
7Spliceosome_Homo sapiens_hsa030403.09732373
8Ribosome_Homo sapiens_hsa030103.03477163
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.86011022
10Nucleotide excision repair_Homo sapiens_hsa034202.85294834
11Base excision repair_Homo sapiens_hsa034102.67897538
12One carbon pool by folate_Homo sapiens_hsa006702.60723415
13Non-homologous end-joining_Homo sapiens_hsa034502.57143146
14Pyrimidine metabolism_Homo sapiens_hsa002402.39073708
15Oxidative phosphorylation_Homo sapiens_hsa001902.35013230
16RNA transport_Homo sapiens_hsa030132.29261502
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19839532
18Cell cycle_Homo sapiens_hsa041102.07046279
19Parkinsons disease_Homo sapiens_hsa050122.06276773
20Selenocompound metabolism_Homo sapiens_hsa004501.91245704
21Basal transcription factors_Homo sapiens_hsa030221.81246144
22Proteasome_Homo sapiens_hsa030501.70654916
23p53 signaling pathway_Homo sapiens_hsa041151.69761054
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.62676550
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54912143
26Systemic lupus erythematosus_Homo sapiens_hsa053221.52759563
27mRNA surveillance pathway_Homo sapiens_hsa030151.51340438
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44917459
29RNA degradation_Homo sapiens_hsa030181.43609160
30Purine metabolism_Homo sapiens_hsa002301.34412891
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.30528789
32Cardiac muscle contraction_Homo sapiens_hsa042601.29055509
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27150598
34Biosynthesis of amino acids_Homo sapiens_hsa012301.26083248
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19754061
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19479967
37Alzheimers disease_Homo sapiens_hsa050101.14961348
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14078536
39Other glycan degradation_Homo sapiens_hsa005111.13828292
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13721753
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12139964
42Primary immunodeficiency_Homo sapiens_hsa053401.10711970
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04246605
44Epstein-Barr virus infection_Homo sapiens_hsa051691.02148197
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99405689
46Herpes simplex infection_Homo sapiens_hsa051680.92333724
47Vitamin B6 metabolism_Homo sapiens_hsa007500.91257396
48Sphingolipid metabolism_Homo sapiens_hsa006000.90822548
49Steroid biosynthesis_Homo sapiens_hsa001000.85737593
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84844833
51Notch signaling pathway_Homo sapiens_hsa043300.80333269
52Measles_Homo sapiens_hsa051620.78340943
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78107444
54Viral carcinogenesis_Homo sapiens_hsa052030.77494985
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.76610317
56Melanoma_Homo sapiens_hsa052180.76488332
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72520345
58Butanoate metabolism_Homo sapiens_hsa006500.68957713
59MicroRNAs in cancer_Homo sapiens_hsa052060.68499445
60Arachidonic acid metabolism_Homo sapiens_hsa005900.66175129
61Arginine and proline metabolism_Homo sapiens_hsa003300.65536819
62Alcoholism_Homo sapiens_hsa050340.64712349
63Peroxisome_Homo sapiens_hsa041460.64298099
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62433689
65Apoptosis_Homo sapiens_hsa042100.62366072
66Pyruvate metabolism_Homo sapiens_hsa006200.61304646
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58940814
68Hematopoietic cell lineage_Homo sapiens_hsa046400.58030516
69HTLV-I infection_Homo sapiens_hsa051660.55446677
70Carbon metabolism_Homo sapiens_hsa012000.53267604
71Linoleic acid metabolism_Homo sapiens_hsa005910.52613127
72Phototransduction_Homo sapiens_hsa047440.52214493
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52079791
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51207096
75Folate biosynthesis_Homo sapiens_hsa007900.49743275
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.48179383
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47727696
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47109315
79Basal cell carcinoma_Homo sapiens_hsa052170.46995380
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.46549429
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45989768
82Regulation of autophagy_Homo sapiens_hsa041400.45782852
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45492326
84Nicotine addiction_Homo sapiens_hsa050330.44435507
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43104539
86Antigen processing and presentation_Homo sapiens_hsa046120.42160837
87Protein export_Homo sapiens_hsa030600.41308942
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40196468
89Small cell lung cancer_Homo sapiens_hsa052220.39732500
90Fatty acid elongation_Homo sapiens_hsa000620.37912404
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.37907103
92N-Glycan biosynthesis_Homo sapiens_hsa005100.37003607
93Sulfur relay system_Homo sapiens_hsa041220.35105223
94Pathways in cancer_Homo sapiens_hsa052000.34973321
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34567810
96Pentose phosphate pathway_Homo sapiens_hsa000300.34107743
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32622432
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32211952
99Ether lipid metabolism_Homo sapiens_hsa005650.32192436
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.32089563
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30977158
102Lysine degradation_Homo sapiens_hsa003100.30689121
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.30640300
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29442883
105Arginine biosynthesis_Homo sapiens_hsa002200.29017421
106Graft-versus-host disease_Homo sapiens_hsa053320.28519652
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28250704
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27826922
109Propanoate metabolism_Homo sapiens_hsa006400.27567008
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27555219
111Autoimmune thyroid disease_Homo sapiens_hsa053200.27421999
112Glutathione metabolism_Homo sapiens_hsa004800.27414010
113Vitamin digestion and absorption_Homo sapiens_hsa049770.26472294
114Fat digestion and absorption_Homo sapiens_hsa049750.26426079
115Nitrogen metabolism_Homo sapiens_hsa009100.26080715
116Fructose and mannose metabolism_Homo sapiens_hsa000510.25755879
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25194673
118Hedgehog signaling pathway_Homo sapiens_hsa043400.24757942
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24260594
120Wnt signaling pathway_Homo sapiens_hsa043100.23748819
121Huntingtons disease_Homo sapiens_hsa050160.23594731
122Axon guidance_Homo sapiens_hsa043600.22839556
123Metabolic pathways_Homo sapiens_hsa011000.22773808
124Tryptophan metabolism_Homo sapiens_hsa003800.22639995
125Bladder cancer_Homo sapiens_hsa052190.20577266
126Acute myeloid leukemia_Homo sapiens_hsa052210.20435699
127Taste transduction_Homo sapiens_hsa047420.20326841
128Hepatitis B_Homo sapiens_hsa051610.19434960
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19179818
130T cell receptor signaling pathway_Homo sapiens_hsa046600.18944954
131Colorectal cancer_Homo sapiens_hsa052100.18275137
132Prostate cancer_Homo sapiens_hsa052150.18168315
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17971241
134Oocyte meiosis_Homo sapiens_hsa041140.17408830
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.16753062
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15407933
137MAPK signaling pathway_Homo sapiens_hsa040100.15274557
138Hippo signaling pathway_Homo sapiens_hsa043900.14055085
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13645082
140Fatty acid metabolism_Homo sapiens_hsa012120.13105373
141TGF-beta signaling pathway_Homo sapiens_hsa043500.11884796
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10084426

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