ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore organization (GO:0006999)	5.03746145
2	nuclear pore complex assembly (GO:0051292)	4.97375554
3	establishment of integrated proviral latency (GO:0075713)	4.50294142
4	mitotic metaphase plate congression (GO:0007080)	4.49266441
5	DNA replication initiation (GO:0006270)	4.31407409
6	maturation of SSU-rRNA (GO:0030490)	4.20964806
7	nucleobase biosynthetic process (GO:0046112)	4.17654382
8	formation of translation preinitiation complex (GO:0001731)	4.13479778
9	ribosome assembly (GO:0042255)	4.05211712
10	DNA unwinding involved in DNA replication (GO:0006268)	4.01865408
11	DNA strand elongation involved in DNA replication (GO:0006271)	4.01366587
12	purine nucleobase biosynthetic process (GO:0009113)	4.00309768
13	metaphase plate congression (GO:0051310)	3.99437795
14	IMP biosynthetic process (GO:0006188)	3.96141144
15	DNA replication checkpoint (GO:0000076)	3.96055982
16	protein localization to kinetochore (GO:0034501)	3.96013483
17	pore complex assembly (GO:0046931)	3.93939530
18	mitotic nuclear envelope disassembly (GO:0007077)	3.91875894
19	chromatin remodeling at centromere (GO:0031055)	3.89882189
20	* ribosome biogenesis (GO:0042254)	3.85979712
21	CENP-A containing nucleosome assembly (GO:0034080)	3.85135413
22	DNA strand elongation (GO:0022616)	3.82904344
23	telomere maintenance via semi-conservative replication (GO:0032201)	3.78884368
24	DNA replication-dependent nucleosome organization (GO:0034723)	3.77058771
25	DNA replication-dependent nucleosome assembly (GO:0006335)	3.77058771
26	kinetochore organization (GO:0051383)	3.75293211
27	IMP metabolic process (GO:0046040)	3.66749171
28	DNA replication-independent nucleosome assembly (GO:0006336)	3.64529788
29	DNA replication-independent nucleosome organization (GO:0034724)	3.64529788
30	establishment of chromosome localization (GO:0051303)	3.61825420
31	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.61781062
32	nuclear envelope disassembly (GO:0051081)	3.60866282
33	membrane disassembly (GO:0030397)	3.60866282
34	* ribonucleoprotein complex biogenesis (GO:0022613)	3.56152510
35	tRNA aminoacylation for protein translation (GO:0006418)	3.55100110
36	telomere maintenance via recombination (GO:0000722)	3.54411825
37	tRNA aminoacylation (GO:0043039)	3.53141577
38	amino acid activation (GO:0043038)	3.53141577
39	ribosomal large subunit biogenesis (GO:0042273)	3.51971490
40	meiotic chromosome segregation (GO:0045132)	3.49877336
41	ribosomal small subunit assembly (GO:0000028)	3.48892431
42	attachment of spindle microtubules to kinetochore (GO:0008608)	3.47547841
43	establishment of viral latency (GO:0019043)	3.46104126
44	regulation of spindle organization (GO:0090224)	3.42489705
45	mitotic recombination (GO:0006312)	3.41662420
46	folic acid-containing compound biosynthetic process (GO:0009396)	3.41644052
47	mitochondrial RNA metabolic process (GO:0000959)	3.38641694
48	double-strand break repair via nonhomologous end joining (GO:0006303)	3.37460993
49	non-recombinational repair (GO:0000726)	3.37460993
50	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.36800857
51	negative regulation of ligase activity (GO:0051352)	3.36800857
52	rRNA processing (GO:0006364)	3.36632376
53	histone exchange (GO:0043486)	3.35555800
54	viral mRNA export from host cell nucleus (GO:0046784)	3.33772201
55	protein localization to chromosome, centromeric region (GO:0071459)	3.33580430
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.33247837
57	telomere maintenance via telomere lengthening (GO:0010833)	3.31917897
58	kinetochore assembly (GO:0051382)	3.31843798
59	regulation of translational fidelity (GO:0006450)	3.29712267
60	spliceosomal snRNP assembly (GO:0000387)	3.26794212
61	rRNA metabolic process (GO:0016072)	3.26635762
62	protein complex localization (GO:0031503)	3.26605544
63	mitotic chromosome condensation (GO:0007076)	3.25382490
64	cellular protein complex localization (GO:0034629)	3.23714159
65	regulation of helicase activity (GO:0051095)	3.23428805
66	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.19711625
67	maturation of 5.8S rRNA (GO:0000460)	3.19217782
68	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.18509582
69	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.16749058
70	spindle checkpoint (GO:0031577)	3.15819353
71	protein K6-linked ubiquitination (GO:0085020)	3.13361212
72	tRNA methylation (GO:0030488)	3.13056898
73	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.09732081
74	negative regulation of sister chromatid segregation (GO:0033046)	3.09732081
75	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.09732081
76	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.09732081
77	negative regulation of mRNA processing (GO:0050686)	3.09549999
78	negative regulation of chromosome segregation (GO:0051985)	3.09255228
79	G1/S transition of mitotic cell cycle (GO:0000082)	3.07211081
80	cell cycle G1/S phase transition (GO:0044843)	3.07211081
81	mitotic sister chromatid cohesion (GO:0007064)	3.07076957
82	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.06876480
83	DNA ligation (GO:0006266)	3.06534777
84	regulation of centrosome cycle (GO:0046605)	3.05953380
85	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.04865113
86	mitotic spindle checkpoint (GO:0071174)	3.04190779
87	spindle assembly checkpoint (GO:0071173)	3.02945368
88	pteridine-containing compound biosynthetic process (GO:0042559)	3.02569371
89	mitotic sister chromatid segregation (GO:0000070)	3.02422297
90	rRNA methylation (GO:0031167)	3.02143303
91	pseudouridine synthesis (GO:0001522)	3.01387885
92	mitotic spindle assembly checkpoint (GO:0007094)	3.01134639
93	DNA duplex unwinding (GO:0032508)	3.01067672
94	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.00893413
95	DNA geometric change (GO:0032392)	3.00639875
96	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.99994361
97	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.99218716
98	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.97451125
99	proteasome assembly (GO:0043248)	2.97171428
100	regulation of mitotic spindle organization (GO:0060236)	2.96332523
101	ribosomal small subunit biogenesis (GO:0042274)	2.95707922
102	regulation of gene silencing by RNA (GO:0060966)	2.95515069
103	regulation of posttranscriptional gene silencing (GO:0060147)	2.95515069
104	regulation of gene silencing by miRNA (GO:0060964)	2.95515069
105	regulation of centriole replication (GO:0046599)	2.95299444
106	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.94569777
107	regulation of chromosome segregation (GO:0051983)	2.94524662
108	regulation of translational termination (GO:0006449)	2.93668829
109	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.93247128
110	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.93247128
111	isotype switching (GO:0045190)	2.93247128
112	positive regulation of chromosome segregation (GO:0051984)	2.91992315
113	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.91588625
114	transcription-coupled nucleotide-excision repair (GO:0006283)	2.89909037
115	chromatin assembly or disassembly (GO:0006333)	2.88817608
116	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.88125729
117	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.88039517
118	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.88039517
119	rRNA modification (GO:0000154)	2.87398657
120	regulation of sister chromatid segregation (GO:0033045)	2.87035404
121	regulation of mitotic sister chromatid separation (GO:0010965)	2.87035404
122	regulation of mitotic sister chromatid segregation (GO:0033047)	2.87035404
123	termination of RNA polymerase I transcription (GO:0006363)	2.86296863
124	translational initiation (GO:0006413)	2.84124611
125	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.82582399
126	RNA splicing, via transesterification reactions (GO:0000375)	2.81620213
127	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81061890
128	termination of RNA polymerase III transcription (GO:0006386)	2.81061890
129	sister chromatid segregation (GO:0000819)	2.80917635

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.02125755
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.50989055
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.96654869
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.80477751
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.17014887
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.14955116
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.13765237
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.12810047
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02209709
10	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.94321780
11	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90528950
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.68494592
13	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.67757498
14	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.67321526
15	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61250280
16	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.53534536
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.39276101
18	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.38437769
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.37120159
20	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.30714930
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.25917656
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.24617992
23	AR_21909140_ChIP-Seq_LNCAP_Human	2.23802038
24	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.22731603
25	XRN2_22483619_ChIP-Seq_HELA_Human	2.22632234
26	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.12675157
27	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.12550515
28	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.02252968
29	ELK1_19687146_ChIP-ChIP_HELA_Human	2.02158229
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95858890
31	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.95461863
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92650372
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.89829472
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87476264
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82847535
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.82826914
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.78678368
38	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74987638
39	* GABP_19822575_ChIP-Seq_HepG2_Human	1.71163020
40	* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.70360857
41	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.65869719
42	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.63076897
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.57310410
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.55055341
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.54798428
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.54756318
47	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54571999
48	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.51373874
49	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51182941
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.47818068
51	KDM5A_27292631_Chip-Seq_BREAST_Human	1.46792774
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43178419
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42792788
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.39121991
55	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39068044
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38258910
57	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.36896048
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.35442881
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.34615393
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.33848607
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32037692
62	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.28947503
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26372703
64	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.24674506
65	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.22181337
66	MYC_22102868_ChIP-Seq_BL_Human	1.22054481
67	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20059870
68	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.19958255
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.18266153
70	TFEB_21752829_ChIP-Seq_HELA_Human	1.17248515
71	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.13951126
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.11772138
73	MYC_18940864_ChIP-ChIP_HL60_Human	1.10417562
74	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.09577484
75	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.09447295
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.08863090
77	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.06905169
78	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.03745570
79	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.02455215
80	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.02380038
81	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02152492
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.01188330
83	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.99910123
84	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.99010826
85	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.99010826
86	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.99010826
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.98500156
88	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.98354263
89	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.96437734
90	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96275759
91	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.94000732
92	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.92368576
93	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.91949057
94	ZNF263_19887448_ChIP-Seq_K562_Human	0.91481985
95	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.91468627
96	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.90050813
97	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.89457218
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.88939833
99	* SPI1_23547873_ChIP-Seq_NB4_Human	0.88896791
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85842456
101	* ELF5_23300383_ChIP-Seq_T47D_Human	0.84888243
102	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.84810087
103	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.83818111
104	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.82490686
105	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.81548771
106	* PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.80671810
107	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.79839680
108	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.79314085
109	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.78985587
110	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.78285138
111	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.77993603
112	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.77669196
113	* NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.76137560
114	EWS_26573619_Chip-Seq_HEK293_Human	0.73407494
115	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.72061637

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	5.03648511
2	MP0010094_abnormal_chromosome_stability	4.48345080
3	MP0008057_abnormal_DNA_replication	4.37653275
4	MP0004957_abnormal_blastocyst_morpholog	4.23487853
5	MP0003111_abnormal_nucleus_morphology	4.12647504
6	MP0003077_abnormal_cell_cycle	3.89191581
7	MP0008058_abnormal_DNA_repair	3.68487100
8	MP0008007_abnormal_cellular_replicative	2.92507182
9	MP0008877_abnormal_DNA_methylation	2.86984029
10	MP0008932_abnormal_embryonic_tissue	2.63160336
11	MP0003123_paternal_imprinting	2.56782079
12	MP0010352_gastrointestinal_tract_polyps	2.37880757
13	MP0002396_abnormal_hematopoietic_system	2.30379300
14	MP0001730_embryonic_growth_arrest	2.27330779
15	MP0000350_abnormal_cell_proliferation	2.22476359
16	MP0010307_abnormal_tumor_latency	2.18171795
17	MP0003786_premature_aging	2.16453620
18	MP0005380_embryogenesis_phenotype	1.75062524
19	MP0001672_abnormal_embryogenesis/_devel	1.75062524
20	MP0001697_abnormal_embryo_size	1.66956865
21	MP0003718_maternal_effect	1.64688195
22	MP0003950_abnormal_plasma_membrane	1.61482086
23	MP0003984_embryonic_growth_retardation	1.58484490
24	MP0003567_abnormal_fetal_cardiomyocyte	1.55579529
25	MP0002088_abnormal_embryonic_growth/wei	1.54369438
26	MP0006035_abnormal_mitochondrial_morpho	1.52946495
27	MP0000490_abnormal_crypts_of	1.52511154
28	MP0002877_abnormal_melanocyte_morpholog	1.50319652
29	MP0004197_abnormal_fetal_growth/weight/	1.48376247
30	MP0003121_genomic_imprinting	1.46790927
31	MP0002084_abnormal_developmental_patter	1.46196080
32	MP0003890_abnormal_embryonic-extraembry	1.45140723
33	MP0002080_prenatal_lethality	1.44565973
34	MP0004808_abnormal_hematopoietic_stem	1.44512117
35	MP0002210_abnormal_sex_determination	1.44214452
36	MP0001661_extended_life_span	1.43717515
37	MP0002085_abnormal_embryonic_tissue	1.42319640
38	MP0002086_abnormal_extraembryonic_tissu	1.38260761
39	MP0000313_abnormal_cell_death	1.35753481
40	MP0006036_abnormal_mitochondrial_physio	1.34525181
41	MP0002019_abnormal_tumor_incidence	1.32189971
42	MP0004233_abnormal_muscle_weight	1.29706839
43	MP0001293_anophthalmia	1.28322038
44	MP0005076_abnormal_cell_differentiation	1.23487923
45	MP0001145_abnormal_male_reproductive	1.21168083
46	MP0005501_abnormal_skin_physiology	1.16425323
47	MP0006292_abnormal_olfactory_placode	1.14035772
48	MP0003763_abnormal_thymus_physiology	1.13944172
49	MP0003806_abnormal_nucleotide_metabolis	1.12397830
50	MP0010030_abnormal_orbit_morphology	1.08771522
51	MP0001929_abnormal_gametogenesis	1.08024211
52	MP0009333_abnormal_splenocyte_physiolog	1.07953117
53	MP0000653_abnormal_sex_gland	1.07482050
54	MP0010234_abnormal_vibrissa_follicle	1.05015426
55	MP0001727_abnormal_embryo_implantation	1.02672649
56	MP0003941_abnormal_skin_development	1.02508836
57	MP0001835_abnormal_antigen_presentation	1.02388559
58	MP0002938_white_spotting	1.01647512
59	MP0001119_abnormal_female_reproductive	1.00505438
60	MP0000703_abnormal_thymus_morphology	0.99492150
61	MP0004133_heterotaxia	0.99421088
62	MP0002398_abnormal_bone_marrow	0.99353085
63	MP0002697_abnormal_eye_size	0.99342941
64	MP0003937_abnormal_limbs/digits/tail_de	0.97840660
65	MP0003186_abnormal_redox_activity	0.95849402
66	MP0003315_abnormal_perineum_morphology	0.94928719
67	MP0005397_hematopoietic_system_phenotyp	0.92589024
68	MP0001545_abnormal_hematopoietic_system	0.92589024
69	MP0001881_abnormal_mammary_gland	0.92506570
70	MP0002796_impaired_skin_barrier	0.91700891
71	MP0001853_heart_inflammation	0.89769545
72	MP0002722_abnormal_immune_system	0.89580007
73	MP0009053_abnormal_anal_canal	0.87850003
74	MP0000689_abnormal_spleen_morphology	0.87653848
75	MP0002160_abnormal_reproductive_system	0.85634959
76	MP0005408_hypopigmentation	0.85398074
77	MP0009672_abnormal_birth_weight	0.82800483
78	MP0004185_abnormal_adipocyte_glucose	0.81335698
79	MP0002111_abnormal_tail_morphology	0.80993602
80	MP0005389_reproductive_system_phenotype	0.79391776
81	MP0000858_altered_metastatic_potential	0.79111185
82	MP0001915_intracranial_hemorrhage	0.76894830
83	MP0009703_decreased_birth_body	0.76671275
84	MP0000579_abnormal_nail_morphology	0.76117498
85	MP0003119_abnormal_digestive_system	0.75406346
86	MP0002429_abnormal_blood_cell	0.75055393
87	MP0001529_abnormal_vocalization	0.74956604
88	MP0006072_abnormal_retinal_apoptosis	0.74804677
89	MP0001286_abnormal_eye_development	0.74543092
90	MP0000647_abnormal_sebaceous_gland	0.74013334
91	MP0005384_cellular_phenotype	0.73709085
92	MP0005623_abnormal_meninges_morphology	0.73651469
93	MP0000566_synostosis	0.72999547
94	MP0002060_abnormal_skin_morphology	0.72612507
95	MP0003787_abnormal_imprinting	0.72375952
96	MP0001216_abnormal_epidermal_layer	0.72025051
97	MP0003566_abnormal_cell_adhesion	0.71990738
98	MP0003448_altered_tumor_morphology	0.71891783
99	MP0005621_abnormal_cell_physiology	0.70377651
100	MP0000358_abnormal_cell_content/	0.69328828
101	MP0000716_abnormal_immune_system	0.68990688
102	MP0005023_abnormal_wound_healing	0.68804736
103	MP0002009_preneoplasia	0.68288744
104	MP0002006_tumorigenesis	0.67887551
105	MP0003221_abnormal_cardiomyocyte_apopto	0.67656198
106	MP0003755_abnormal_palate_morphology	0.67242320
107	MP0004147_increased_porphyrin_level	0.65801436
108	MP0005671_abnormal_response_to	0.65492739
109	MP0001800_abnormal_humoral_immune	0.65469417
110	MP0002163_abnormal_gland_morphology	0.65057620
111	MP0002234_abnormal_pharynx_morphology	0.64767599
112	MP0003936_abnormal_reproductive_system	0.63659295
113	MP0000432_abnormal_head_morphology	0.63337738
114	MP0000627_abnormal_mammary_gland	0.63038267
115	MP0002405_respiratory_system_inflammati	0.62107069
116	MP0000537_abnormal_urethra_morphology	0.61404117
117	MP0005395_other_phenotype	0.59852512
118	MP0002452_abnormal_antigen_presenting	0.59844623
119	MP0002092_abnormal_eye_morphology	0.59714037
120	MP0009697_abnormal_copulation	0.58215527
121	MP0002254_reproductive_system_inflammat	0.58206615
122	MP0003436_decreased_susceptibility_to	0.57910116
123	MP0000428_abnormal_craniofacial_morphol	0.57691655
124	MP0003699_abnormal_female_reproductive	0.57657675
125	MP0000762_abnormal_tongue_morphology	0.57502359
126	MP0001919_abnormal_reproductive_system	0.57331913
127	MP0003385_abnormal_body_wall	0.57324286
128	MP0002277_abnormal_respiratory_mucosa	0.57166547
129	MP0008995_early_reproductive_senescence	0.56253283
130	MP0002420_abnormal_adaptive_immunity	0.56055043
131	MP0001819_abnormal_immune_cell	0.55533957
132	MP0004272_abnormal_basement_membrane	0.55486371
133	MP0002233_abnormal_nose_morphology	0.53220036
134	MP0001243_abnormal_dermal_layer	0.53210653

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	5.02216894
2	Chromsome breakage (HP:0040012)	4.27599491
3	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.96634745
4	Colon cancer (HP:0003003)	3.89099765
5	Breast hypoplasia (HP:0003187)	3.66705662
6	Medulloblastoma (HP:0002885)	3.51926410
7	Reticulocytopenia (HP:0001896)	3.46199565
8	Abnormality of glycolysis (HP:0004366)	3.37752434
9	Carpal bone hypoplasia (HP:0001498)	3.25171578
10	Abnormality of chromosome stability (HP:0003220)	3.23164817
11	Agnosia (HP:0010524)	3.18557386
12	Oral leukoplakia (HP:0002745)	3.18474857
13	Increased serum pyruvate (HP:0003542)	3.17985470
14	Abnormality of the labia minora (HP:0012880)	3.07249847
15	Patellar aplasia (HP:0006443)	3.03613892
16	Microvesicular hepatic steatosis (HP:0001414)	2.98616113
17	Meckel diverticulum (HP:0002245)	2.98512078
18	Abnormality of the preputium (HP:0100587)	2.97039497
19	Abnormality of cells of the erythroid lineage (HP:0012130)	2.92910246
20	Abnormality of the anterior horn cell (HP:0006802)	2.89637623
21	Degeneration of anterior horn cells (HP:0002398)	2.89637623
22	Abnormal number of erythroid precursors (HP:0012131)	2.81159461
23	Abnormality of the ileum (HP:0001549)	2.79829513
24	Aplasia/Hypoplasia of the patella (HP:0006498)	2.79261984
25	Short middle phalanx of the 5th finger (HP:0004220)	2.78856793
26	Selective tooth agenesis (HP:0001592)	2.77450139
27	Absent radius (HP:0003974)	2.76325142
28	Absent thumb (HP:0009777)	2.75709854
29	Abnormality of alanine metabolism (HP:0010916)	2.73511020
30	Hyperalaninemia (HP:0003348)	2.73511020
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73511020
32	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.73061337
33	Aplastic anemia (HP:0001915)	2.72294246
34	Supernumerary spleens (HP:0009799)	2.72012310
35	Impulsivity (HP:0100710)	2.69447806
36	Myelodysplasia (HP:0002863)	2.67749602
37	Ectopic kidney (HP:0000086)	2.66133457
38	Rough bone trabeculation (HP:0100670)	2.64994451
39	Ependymoma (HP:0002888)	2.64348207
40	Progressive muscle weakness (HP:0003323)	2.60983200
41	Acute necrotizing encephalopathy (HP:0006965)	2.57895278
42	Abnormality of methionine metabolism (HP:0010901)	2.57760078
43	Rhabdomyosarcoma (HP:0002859)	2.55872991
44	Aplasia involving forearm bones (HP:0009822)	2.53232117
45	Absent forearm bone (HP:0003953)	2.53232117
46	Type I transferrin isoform profile (HP:0003642)	2.52801384
47	Acute encephalopathy (HP:0006846)	2.52022943
48	Volvulus (HP:0002580)	2.51822162
49	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46677094
50	Increased CSF lactate (HP:0002490)	2.43353028
51	Increased serum lactate (HP:0002151)	2.40209045
52	11 pairs of ribs (HP:0000878)	2.39994288
53	Overlapping toe (HP:0001845)	2.38549360
54	Duodenal stenosis (HP:0100867)	2.35787191
55	Small intestinal stenosis (HP:0012848)	2.35787191
56	Neoplasm of the pancreas (HP:0002894)	2.34371749
57	Premature graying of hair (HP:0002216)	2.31201964
58	Sloping forehead (HP:0000340)	2.29805040
59	Horseshoe kidney (HP:0000085)	2.28363326
60	Increased hepatocellular lipid droplets (HP:0006565)	2.27743404
61	Deviation of the thumb (HP:0009603)	2.24069987
62	Amaurosis fugax (HP:0100576)	2.23477774
63	Bone marrow hypocellularity (HP:0005528)	2.23330888
64	Proximal placement of thumb (HP:0009623)	2.23330337
65	Abnormal spermatogenesis (HP:0008669)	2.22014855
66	Cerebral hypomyelination (HP:0006808)	2.21170837
67	Irregular epiphyses (HP:0010582)	2.20552419
68	Abnormal number of incisors (HP:0011064)	2.16379259
69	Abnormal protein glycosylation (HP:0012346)	2.15587213
70	Abnormal glycosylation (HP:0012345)	2.15587213
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.15587213
72	Abnormal protein N-linked glycosylation (HP:0012347)	2.15587213
73	Abnormal lung lobation (HP:0002101)	2.15544891
74	Cerebral edema (HP:0002181)	2.15212398
75	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.14907955
76	Short thumb (HP:0009778)	2.13301698
77	Progressive external ophthalmoplegia (HP:0000590)	2.12951623
78	Nephroblastoma (Wilms tumor) (HP:0002667)	2.09271082
79	Cellular immunodeficiency (HP:0005374)	2.08786369
80	Neoplasm of the oral cavity (HP:0100649)	2.08601599
81	Facial hemangioma (HP:0000329)	2.08571699
82	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.07383023
83	Pancytopenia (HP:0001876)	2.06871230
84	Tracheoesophageal fistula (HP:0002575)	2.06016432
85	Reduced antithrombin III activity (HP:0001976)	2.05407934
86	Macrocytic anemia (HP:0001972)	2.03490531
87	Glossoptosis (HP:0000162)	2.02848065
88	Biliary tract neoplasm (HP:0100574)	2.02042660
89	Triphalangeal thumb (HP:0001199)	2.00787621
90	Abnormal trabecular bone morphology (HP:0100671)	2.00096739
91	Cleft eyelid (HP:0000625)	2.00051566
92	Trismus (HP:0000211)	1.99095851
93	Pallor (HP:0000980)	1.98964565
94	Glioma (HP:0009733)	1.98768537
95	Abnormality of the duodenum (HP:0002246)	1.98661832
96	Abnormality of serum amino acid levels (HP:0003112)	1.97244112
97	Mitochondrial inheritance (HP:0001427)	1.96208209
98	Progressive macrocephaly (HP:0004481)	1.94723065
99	Lipid accumulation in hepatocytes (HP:0006561)	1.94333169
100	Abnormality of the pons (HP:0007361)	1.94162982
101	Embryonal renal neoplasm (HP:0011794)	1.94114264
102	Choanal atresia (HP:0000453)	1.93381271
103	Atresia of the external auditory canal (HP:0000413)	1.93285549
104	Postnatal microcephaly (HP:0005484)	1.93024908
105	Cortical dysplasia (HP:0002539)	1.92547728
106	Homocystinuria (HP:0002156)	1.90428178
107	Abnormality of homocysteine metabolism (HP:0010919)	1.90428178
108	Basal cell carcinoma (HP:0002671)	1.88364077
109	Astrocytoma (HP:0009592)	1.88123459
110	Abnormality of the astrocytes (HP:0100707)	1.88123459
111	Neoplasm of the colon (HP:0100273)	1.87695179
112	Hepatocellular necrosis (HP:0001404)	1.87096374
113	Thrombocytosis (HP:0001894)	1.86899248
114	Premature ovarian failure (HP:0008209)	1.86727271
115	Deep philtrum (HP:0002002)	1.86253563
116	Squamous cell carcinoma (HP:0002860)	1.86167030
117	Aplasia/hypoplasia of the humerus (HP:0006507)	1.85372836
118	Lymphoma (HP:0002665)	1.84702780
119	Optic nerve coloboma (HP:0000588)	1.84699786
120	Sparse eyelashes (HP:0000653)	1.84564177
121	Facial cleft (HP:0002006)	1.81999774
122	Acute myeloid leukemia (HP:0004808)	1.81663844
123	Clubbing of toes (HP:0100760)	1.81491464
124	Abnormality of the umbilical cord (HP:0010881)	1.81445975
125	Duplicated collecting system (HP:0000081)	1.81134737
126	Lactic acidosis (HP:0003128)	1.78709454
127	Abnormalities of placenta or umbilical cord (HP:0001194)	1.78038113
128	Spastic diplegia (HP:0001264)	1.77658060
129	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77614685
130	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.76614655
131	Prominent nose (HP:0000448)	1.73417797
132	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.72613871
133	Missing ribs (HP:0000921)	1.72155117
134	Hypoplasia of the pons (HP:0012110)	1.72149200
135	Stenosis of the external auditory canal (HP:0000402)	1.71882870
136	Neoplasm of striated muscle (HP:0009728)	1.71396576
137	Abnormality of the carotid arteries (HP:0005344)	1.71162094
138	Multiple enchondromatosis (HP:0005701)	1.70454338
139	High anterior hairline (HP:0009890)	1.69884533
140	Shoulder girdle muscle weakness (HP:0003547)	1.69331101
141	Increased nuchal translucency (HP:0010880)	1.69225399
142	Pelvic girdle muscle weakness (HP:0003749)	1.68862094
143	Secondary amenorrhea (HP:0000869)	1.68749347
144	Pancreatic islet-cell hyperplasia (HP:0004510)	1.68309815
145	Microglossia (HP:0000171)	1.67673697
146	Supernumerary bones of the axial skeleton (HP:0009144)	1.65672843
147	Microretrognathia (HP:0000308)	1.64120903
148	Cafe-au-lait spot (HP:0000957)	1.63696417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.18051213
2	WEE1	4.02413955
3	BUB1	3.99686059
4	EIF2AK1	3.44732267
5	SRPK1	2.93946965
6	ACVR1B	2.83253849
7	PLK4	2.59148604
8	VRK2	2.53886327
9	TSSK6	2.52303438
10	MKNK1	2.45310260
11	NEK2	2.35391764
12	BRSK2	2.24896730
13	EIF2AK3	2.23022922
14	TTK	2.22497597
15	NEK1	2.18806862
16	MKNK2	2.15531253
17	PLK1	2.01323490
18	PLK3	1.91675196
19	CDK12	1.91453560
20	NME2	1.72509917
21	PASK	1.70371383
22	ATR	1.68530231
23	AURKB	1.68302515
24	STK16	1.66114691
25	CDK7	1.61162025
26	TAF1	1.60594079
27	NME1	1.56002201
28	RPS6KA4	1.54507129
29	EPHA2	1.50580062
30	VRK1	1.48983614
31	DYRK3	1.34684836
32	BRD4	1.34294230
33	CHEK1	1.32650135
34	TRIM28	1.31902446
35	TGFBR1	1.30666869
36	ZAK	1.30011155
37	CHEK2	1.27454545
38	RPS6KB2	1.26825475
39	EIF2AK2	1.16109259
40	PBK	1.13727054
41	CDK4	1.12090724
42	PIM1	1.11113481
43	STK10	1.09362481
44	MAP3K8	1.06025738
45	TLK1	1.05702929
46	ERBB4	1.05462598
47	STK38L	1.03527415
48	SMG1	1.00738403
49	ATM	1.00376374
50	AURKA	0.99312200
51	CCNB1	0.98658218
52	PNCK	0.95008018
53	STK4	0.92918645
54	BRSK1	0.89001504
55	CDK2	0.87993927
56	MAP3K12	0.84455881
57	PIM2	0.81722128
58	STK3	0.81126674
59	ALK	0.80953940
60	MELK	0.79157968
61	PAK4	0.77434199
62	TESK2	0.77339624
63	CSNK2A2	0.76715917
64	CLK1	0.74516295
65	CDK6	0.69841471
66	MST1R	0.69628090
67	CSNK2A1	0.69005491
68	FLT3	0.68344229
69	SCYL2	0.68163666
70	LATS1	0.68145421
71	CDK1	0.65890237
72	IRAK4	0.64433182
73	MAP2K3	0.63603685
74	MST4	0.62504604
75	RPS6KA5	0.61231131
76	TEC	0.61198281
77	CHUK	0.60929518
78	MAP4K1	0.57396612
79	CDK8	0.57381362
80	EEF2K	0.53029498
81	NEK9	0.51755055
82	TXK	0.50778025
83	JAK3	0.50202922
84	LATS2	0.48832580
85	IKBKB	0.46483961
86	MAP3K3	0.46223117
87	FGFR1	0.45989014
88	MAP3K14	0.44708191
89	NLK	0.43863767
90	NUAK1	0.43196621
91	ERBB3	0.43183085
92	PAK1	0.43087737
93	MARK3	0.42753972
94	PRKCI	0.40625303
95	AKT2	0.40427476
96	CSNK1E	0.40015660
97	STK24	0.38754374
98	IRAK3	0.38360405
99	MAPKAPK5	0.37219437
100	CSNK1G1	0.35868299
101	PAK2	0.34113082
102	PRKDC	0.33893409
103	BMPR1B	0.33885414
104	KDR	0.32889698
105	MET	0.32850508
106	CDK9	0.32428752
107	AKT3	0.31545352
108	DAPK1	0.31511439
109	RPS6KB1	0.31029246
110	PLK2	0.30646124
111	BTK	0.29814064
112	PDK2	0.29458352
113	MAP3K10	0.29318112
114	BCR	0.29069389
115	ZAP70	0.28728078
116	CSNK1G3	0.28683325
117	ILK	0.28604175
118	MAPK14	0.28568229
119	YES1	0.28313863
120	CSNK1A1L	0.27404997
121	BRAF	0.26923638
122	MAP3K5	0.26119007
123	STK39	0.24316403
124	RAF1	0.22893260
125	TNIK	0.20477426
126	MTOR	0.20064337

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.42709636
2	* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.18771271
3	Mismatch repair_Homo sapiens_hsa03430	3.89319237
4	RNA polymerase_Homo sapiens_hsa03020	3.48031977
5	Spliceosome_Homo sapiens_hsa03040	3.32776570
6	RNA transport_Homo sapiens_hsa03013	3.31889597
7	Proteasome_Homo sapiens_hsa03050	3.30340371
8	Homologous recombination_Homo sapiens_hsa03440	2.99573393
9	Ribosome_Homo sapiens_hsa03010	2.81886393
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.73093243
11	One carbon pool by folate_Homo sapiens_hsa00670	2.69331881
12	Cell cycle_Homo sapiens_hsa04110	2.67472672
13	Base excision repair_Homo sapiens_hsa03410	2.66603255
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.57010628
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.30090525
16	Pyrimidine metabolism_Homo sapiens_hsa00240	2.28767590
17	Basal transcription factors_Homo sapiens_hsa03022	2.28651501
18	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.15183283
19	Non-homologous end-joining_Homo sapiens_hsa03450	2.11689926
20	RNA degradation_Homo sapiens_hsa03018	2.08128178
21	mRNA surveillance pathway_Homo sapiens_hsa03015	1.88096336
22	p53 signaling pathway_Homo sapiens_hsa04115	1.59791058
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50605013
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46817284
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.45614975
26	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.38508131
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.33684855
28	Purine metabolism_Homo sapiens_hsa00230	1.26377845
29	Herpes simplex infection_Homo sapiens_hsa05168	1.20734364
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.16832212
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.13971904
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12616214
33	Parkinsons disease_Homo sapiens_hsa05012	1.10962230
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.06938357
35	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.06348770
36	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06338782
37	Propanoate metabolism_Homo sapiens_hsa00640	1.04224551
38	Viral carcinogenesis_Homo sapiens_hsa05203	1.01113527
39	Allograft rejection_Homo sapiens_hsa05330	0.92107628
40	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.86641384
41	Legionellosis_Homo sapiens_hsa05134	0.85078590
42	HTLV-I infection_Homo sapiens_hsa05166	0.82403581
43	Selenocompound metabolism_Homo sapiens_hsa00450	0.77786721
44	Oocyte meiosis_Homo sapiens_hsa04114	0.77105777
45	Fatty acid elongation_Homo sapiens_hsa00062	0.74756677
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.74373314
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.73610150
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73127401
49	MicroRNAs in cancer_Homo sapiens_hsa05206	0.73105731
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.70111224
51	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.69841222
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.68435073
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68417738
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66243678
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66096972
56	Measles_Homo sapiens_hsa05162	0.65088418
57	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.62156239
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61782407
59	Thyroid cancer_Homo sapiens_hsa05216	0.61605970
60	Protein export_Homo sapiens_hsa03060	0.59578525
61	Folate biosynthesis_Homo sapiens_hsa00790	0.58340769
62	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.58230548
63	Small cell lung cancer_Homo sapiens_hsa05222	0.58123701
64	Sulfur relay system_Homo sapiens_hsa04122	0.57923188
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55806299
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55405837
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.55266947
68	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.55225890
69	Lysine degradation_Homo sapiens_hsa00310	0.52329339
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.52007022
71	Apoptosis_Homo sapiens_hsa04210	0.51942685
72	Primary immunodeficiency_Homo sapiens_hsa05340	0.51066484
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49784650
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49476159
75	Influenza A_Homo sapiens_hsa05164	0.48421564
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.47980330
77	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47698265
78	Alzheimers disease_Homo sapiens_hsa05010	0.46766580
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46609293
80	Metabolic pathways_Homo sapiens_hsa01100	0.46503452
81	Asthma_Homo sapiens_hsa05310	0.45226220
82	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.44282523
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44273838
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.41493473
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40681435
86	Sulfur metabolism_Homo sapiens_hsa00920	0.40184246
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.39843117
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.39211722
89	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.39048936
90	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.38393462
91	Hepatitis B_Homo sapiens_hsa05161	0.38102042
92	Shigellosis_Homo sapiens_hsa05131	0.36407178
93	Bladder cancer_Homo sapiens_hsa05219	0.35886792
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.34186249
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33997925
96	Colorectal cancer_Homo sapiens_hsa05210	0.32133917
97	Viral myocarditis_Homo sapiens_hsa05416	0.31967581
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30081577
99	Glutathione metabolism_Homo sapiens_hsa00480	0.30045750
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.29765906
101	Adherens junction_Homo sapiens_hsa04520	0.29570452
102	Galactose metabolism_Homo sapiens_hsa00052	0.29152869
103	Leishmaniasis_Homo sapiens_hsa05140	0.28623498
104	Huntingtons disease_Homo sapiens_hsa05016	0.28077513
105	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27179319
106	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.27116898
107	Fatty acid metabolism_Homo sapiens_hsa01212	0.26755889
108	Pathways in cancer_Homo sapiens_hsa05200	0.26251757
109	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25767337
110	Arginine and proline metabolism_Homo sapiens_hsa00330	0.25766294
111	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.24901182
112	Prostate cancer_Homo sapiens_hsa05215	0.23826741
113	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.23122457
114	Alcoholism_Homo sapiens_hsa05034	0.22993988
115	Notch signaling pathway_Homo sapiens_hsa04330	0.22499586
116	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21236093
117	Acute myeloid leukemia_Homo sapiens_hsa05221	0.20995581
118	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.20054544
119	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.19552312
120	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.17830419
121	Carbon metabolism_Homo sapiens_hsa01200	0.17521965
122	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.17167330
123	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.16394894
124	TNF signaling pathway_Homo sapiens_hsa04668	0.14854403
125	Wnt signaling pathway_Homo sapiens_hsa04310	0.13926651
126	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.12847509
127	FoxO signaling pathway_Homo sapiens_hsa04068	0.12716615
128	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.11550245
129	Tight junction_Homo sapiens_hsa04530	0.11219414
130	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.10320441
131	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.10185239
132	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.08902349
133	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.08822258
134	Malaria_Homo sapiens_hsa05144	0.07741000
135	Peroxisome_Homo sapiens_hsa04146	0.06174130

GTPBP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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