GTPBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.48045232
2ribosomal small subunit assembly (GO:0000028)4.43190248
3DNA deamination (GO:0045006)4.37451204
4purine nucleobase biosynthetic process (GO:0009113)4.18066400
5dopamine transport (GO:0015872)4.09337157
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05791448
7protein neddylation (GO:0045116)3.97710791
8chromatin remodeling at centromere (GO:0031055)3.97537944
9CENP-A containing nucleosome assembly (GO:0034080)3.90398645
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87598104
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79187629
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.79187629
13NADH dehydrogenase complex assembly (GO:0010257)3.79187629
14termination of RNA polymerase III transcription (GO:0006386)3.73531115
15transcription elongation from RNA polymerase III promoter (GO:0006385)3.73531115
16polyketide metabolic process (GO:0030638)3.71916517
17doxorubicin metabolic process (GO:0044598)3.71916517
18daunorubicin metabolic process (GO:0044597)3.71916517
19amino acid salvage (GO:0043102)3.70395686
20L-methionine salvage (GO:0071267)3.70395686
21L-methionine biosynthetic process (GO:0071265)3.70395686
22protein complex biogenesis (GO:0070271)3.59710666
23regulation of mitotic spindle checkpoint (GO:1903504)3.59575508
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59575508
25mitochondrial respiratory chain complex assembly (GO:0033108)3.55443133
26galactose catabolic process (GO:0019388)3.53999586
27regulation of helicase activity (GO:0051095)3.51820005
28replication fork processing (GO:0031297)3.50686162
29positive regulation of respiratory burst (GO:0060267)3.49452130
30nucleobase biosynthetic process (GO:0046112)3.49382636
31protein targeting to mitochondrion (GO:0006626)3.46881056
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45520856
33ATP synthesis coupled proton transport (GO:0015986)3.45520856
34DNA damage response, detection of DNA damage (GO:0042769)3.44514831
35maturation of SSU-rRNA (GO:0030490)3.43577372
36rRNA modification (GO:0000154)3.42855884
37histone exchange (GO:0043486)3.41247700
38electron transport chain (GO:0022900)3.41192067
39viral mRNA export from host cell nucleus (GO:0046784)3.38546255
40water-soluble vitamin biosynthetic process (GO:0042364)3.37540689
41catecholamine transport (GO:0051937)3.33862003
42methionine metabolic process (GO:0006555)3.30382859
43negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.29509286
44ether lipid metabolic process (GO:0046485)3.24652743
45DNA replication checkpoint (GO:0000076)3.23807839
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23553779
47DNA double-strand break processing (GO:0000729)3.21714908
48cytochrome complex assembly (GO:0017004)3.18368876
49oxidative phosphorylation (GO:0006119)3.17948212
50rRNA methylation (GO:0031167)3.15318735
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14880283
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.14880283
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.09684519
54protein-cofactor linkage (GO:0018065)3.09211530
55establishment of protein localization to mitochondrion (GO:0072655)3.07088894
56coenzyme catabolic process (GO:0009109)3.04275598
57pseudouridine synthesis (GO:0001522)3.01337724
58succinate metabolic process (GO:0006105)3.01219930
59S-adenosylmethionine metabolic process (GO:0046500)2.99840963
60protein localization to mitochondrion (GO:0070585)2.98620517
61alpha-linolenic acid metabolic process (GO:0036109)2.96997617
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95750101
63tRNA processing (GO:0008033)2.94578212
64DNA replication-dependent nucleosome assembly (GO:0006335)2.94406807
65DNA replication-dependent nucleosome organization (GO:0034723)2.94406807
66mRNA cleavage (GO:0006379)2.94196109
67DNA replication-independent nucleosome organization (GO:0034724)2.91450991
68DNA replication-independent nucleosome assembly (GO:0006336)2.91450991
69peptidyl-histidine modification (GO:0018202)2.88443107
70behavioral response to nicotine (GO:0035095)2.87589838
71maturation of 5.8S rRNA (GO:0000460)2.87453311
72translational termination (GO:0006415)2.87151541
73purine-containing compound salvage (GO:0043101)2.86333297
74cullin deneddylation (GO:0010388)2.81442069
75translation (GO:0006412)2.81428100
76viral transcription (GO:0019083)2.80429871
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80389353
78synaptic vesicle exocytosis (GO:0016079)2.80295579
79histone mRNA metabolic process (GO:0008334)2.79711809
80recombinational repair (GO:0000725)2.78957380
81protein localization to endoplasmic reticulum (GO:0070972)2.78000102
82kinetochore assembly (GO:0051382)2.76812197
83negative regulation of ligase activity (GO:0051352)2.76584619
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76584619
85organelle disassembly (GO:1903008)2.76052185
86resolution of meiotic recombination intermediates (GO:0000712)2.75712861
87response to pheromone (GO:0019236)2.75284583
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74573012
89platelet dense granule organization (GO:0060155)2.74516302
90double-strand break repair via homologous recombination (GO:0000724)2.73964224
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.73787674
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73512046
93DNA catabolic process, exonucleolytic (GO:0000738)2.72753899
94postreplication repair (GO:0006301)2.72092060
95DNA ligation (GO:0006266)2.71722206
96kinetochore organization (GO:0051383)2.71678452
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.71440701
98ribosomal large subunit biogenesis (GO:0042273)2.70847261
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70130032
100cotranslational protein targeting to membrane (GO:0006613)2.69789844
101negative regulation of RNA splicing (GO:0033119)2.68985893
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.68948335
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68692712
104spliceosomal snRNP assembly (GO:0000387)2.68443401
105telomere maintenance via telomerase (GO:0007004)2.67794801
106inner mitochondrial membrane organization (GO:0007007)2.67618630
107cysteine metabolic process (GO:0006534)2.67443213
108iron-sulfur cluster assembly (GO:0016226)2.66878885
109metallo-sulfur cluster assembly (GO:0031163)2.66878885
110sulfur amino acid biosynthetic process (GO:0000097)2.66544087
111chaperone-mediated protein transport (GO:0072321)2.65791711
112somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65411302
113isotype switching (GO:0045190)2.65411302
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65411302
115synapsis (GO:0007129)2.65288081
116regulation of cellular amino acid metabolic process (GO:0006521)2.65151609
117sulfur amino acid metabolic process (GO:0000096)2.64725067
118triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.64720829
119methionine biosynthetic process (GO:0009086)2.63917459
120tRNA metabolic process (GO:0006399)2.63314092
121negative regulation of telomere maintenance (GO:0032205)2.62860213
122protein targeting to ER (GO:0045047)2.62610130
123tRNA methylation (GO:0030488)2.62440709
124cellular metabolic compound salvage (GO:0043094)2.61542368
125protein deneddylation (GO:0000338)2.61382491
126ribosomal small subunit biogenesis (GO:0042274)2.61241333
127transcription elongation from RNA polymerase I promoter (GO:0006362)2.60842503
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60711550
129rRNA processing (GO:0006364)2.59169358
130proteasome assembly (GO:0043248)2.58605829
131sulfur amino acid catabolic process (GO:0000098)2.58230926
132quinone biosynthetic process (GO:1901663)2.57321860
133ubiquinone biosynthetic process (GO:0006744)2.57321860
134positive regulation of mitochondrial fission (GO:0090141)2.56986055
135endosome to pigment granule transport (GO:0043485)2.56850182
136endosome to melanosome transport (GO:0035646)2.56850182
137establishment of protein localization to endoplasmic reticulum (GO:0072599)2.56344551
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.54511815
139L-phenylalanine catabolic process (GO:0006559)2.54511815
140peptidyl-lysine dimethylation (GO:0018027)2.54122428
141glycine metabolic process (GO:0006544)2.54070465
142response to interferon-alpha (GO:0035455)2.54022112
143mitochondrial transport (GO:0006839)2.51532575
144translational elongation (GO:0006414)2.50820462
145regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.49009504
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47629263
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47629263
148pyrimidine nucleobase catabolic process (GO:0006208)2.47018020
149respiratory electron transport chain (GO:0022904)2.46073670
150respiratory chain complex IV assembly (GO:0008535)2.45258061
151coenzyme A metabolic process (GO:0015936)2.45182753
152translational initiation (GO:0006413)2.44500250
153oxaloacetate metabolic process (GO:0006107)2.44477358
1542-deoxyribonucleotide biosynthetic process (GO:0009265)2.42998524
155deoxyribose phosphate biosynthetic process (GO:0046385)2.42998524
156L-phenylalanine metabolic process (GO:0006558)2.42931658
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.42931658
158mitochondrial RNA metabolic process (GO:0000959)2.42378718
159deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.42272409
160quinone metabolic process (GO:1901661)2.42221310
161cellular component biogenesis (GO:0044085)2.41848465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.98592507
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85654059
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.78771115
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.69526206
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.66849104
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39378273
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.36035125
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32256625
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21564060
10E2F7_22180533_ChIP-Seq_HELA_Human3.07558502
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96616408
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92687127
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81006974
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74852767
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69103449
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62315618
17* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56459922
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56174480
19FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.54664389
20VDR_22108803_ChIP-Seq_LS180_Human2.54198393
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53560267
22GATA1_22025678_ChIP-Seq_K562_Human2.41673567
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38461522
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35705949
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.35705214
26* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35117519
27DCP1A_22483619_ChIP-Seq_HELA_Human2.32220493
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27487349
29VDR_23849224_ChIP-Seq_CD4+_Human2.26475885
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.20622003
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.20235403
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.18305143
33* GABP_19822575_ChIP-Seq_HepG2_Human2.15748580
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15307456
35* XRN2_22483619_ChIP-Seq_HELA_Human2.13184232
36FOXP3_21729870_ChIP-Seq_TREG_Human2.12250311
37ERG_20887958_ChIP-Seq_HPC-7_Mouse2.02511512
38NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02299617
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.01865040
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01434650
41ELK1_19687146_ChIP-ChIP_HELA_Human2.00770386
42IGF1R_20145208_ChIP-Seq_DFB_Human1.93949144
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.91499276
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.90385893
45TAF15_26573619_Chip-Seq_HEK293_Human1.88852603
46MYC_18940864_ChIP-ChIP_HL60_Human1.88538971
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86776822
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86541473
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82094854
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81512559
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81074777
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80315320
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73922125
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72294296
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65652239
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63786822
57P300_19829295_ChIP-Seq_ESCs_Human1.62577106
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60830982
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60500673
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58525211
61TTF2_22483619_ChIP-Seq_HELA_Human1.57149807
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55469778
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54405556
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51923160
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50670894
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50183321
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49377175
68GBX2_23144817_ChIP-Seq_PC3_Human1.47177408
69CIITA_25753668_ChIP-Seq_RAJI_Human1.46563363
70IRF1_19129219_ChIP-ChIP_H3396_Human1.44726179
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44546399
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40512225
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39627305
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.38022463
75* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36132202
76KDM5A_27292631_Chip-Seq_BREAST_Human1.34096776
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34021577
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33047084
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.32425551
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.31940885
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31748470
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29623755
83AR_21909140_ChIP-Seq_LNCAP_Human1.29272193
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27423459
85FUS_26573619_Chip-Seq_HEK293_Human1.24370830
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23520909
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23101248
88* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22418877
89* TP53_22573176_ChIP-Seq_HFKS_Human1.21527458
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21012084
91CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19634459
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.18986587
93ER_23166858_ChIP-Seq_MCF-7_Human1.18700528
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16849698
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16549417
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.15300797
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.15245287
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14835931
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13639899
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.13337952
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13249169
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13169887
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13083944
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11646904
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11638799
106SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10236739
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.09579571
108PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08789382
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08780888
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.08259294
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07772164
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07152832
113ZNF274_21170338_ChIP-Seq_K562_Hela1.07048836
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06362188
115NANOG_19829295_ChIP-Seq_ESCs_Human1.05504947
116SOX2_19829295_ChIP-Seq_ESCs_Human1.05504947
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04804001
118CBP_20019798_ChIP-Seq_JUKART_Human1.04603546
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04603546
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03920317
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03669630
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02574567
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99475013
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98314553
125AR_20517297_ChIP-Seq_VCAP_Human0.95710565
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95448153
127FOXA1_25329375_ChIP-Seq_VCAP_Human0.95144811
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95144811
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94151677
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93861491
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93746453
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93698295
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92939511
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.91692870
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91415604
136SCL_19346495_ChIP-Seq_HPC-7_Human0.89773000
137EWS_26573619_Chip-Seq_HEK293_Human0.89614026
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.88950453
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88710401
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88675658
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88523696
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86287742
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85676879
144FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85241933
145* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82688865
146REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81513731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation5.04441617
2MP0005360_urolithiasis4.49994825
3MP0005365_abnormal_bile_salt3.93798494
4MP0004859_abnormal_synaptic_plasticity3.61074203
5MP0008877_abnormal_DNA_methylation3.28975979
6MP0008058_abnormal_DNA_repair3.24201705
7MP0002102_abnormal_ear_morphology3.13919312
8MP0009379_abnormal_foot_pigmentation2.83316286
9MP0002139_abnormal_hepatobiliary_system2.77160653
10MP0002396_abnormal_hematopoietic_system2.64197037
11MP0006035_abnormal_mitochondrial_morpho2.63566581
12MP0003806_abnormal_nucleotide_metabolis2.50405663
13MP0003136_yellow_coat_color2.41592287
14MP0003656_abnormal_erythrocyte_physiolo2.41221474
15MP0005085_abnormal_gallbladder_physiolo2.40583283
16MP0006072_abnormal_retinal_apoptosis2.39417566
17MP0001764_abnormal_homeostasis2.31755324
18MP0004147_increased_porphyrin_level2.25779627
19MP0001188_hyperpigmentation2.21414350
20MP0008875_abnormal_xenobiotic_pharmacok2.20634050
21MP0008057_abnormal_DNA_replication2.12158187
22MP0003718_maternal_effect2.11627368
23MP0004270_analgesia2.05716772
24MP0002163_abnormal_gland_morphology1.93972821
25MP0004133_heterotaxia1.77568467
26MP0006036_abnormal_mitochondrial_physio1.75264006
27MP0000358_abnormal_cell_content/1.74744432
28MP0003279_aneurysm1.74127028
29MP0010329_abnormal_lipoprotein_level1.73708715
30MP0003693_abnormal_embryo_hatching1.72848646
31MP0002234_abnormal_pharynx_morphology1.72603894
32MP0002095_abnormal_skin_pigmentation1.70423502
33MP0008569_lethality_at_weaning1.70234185
34MP0003635_abnormal_synaptic_transmissio1.66997977
35MP0003329_amyloid_beta_deposits1.62853488
36MP0005379_endocrine/exocrine_gland_phen1.58907123
37MP0008789_abnormal_olfactory_epithelium1.58716264
38MP0009384_cardiac_valve_regurgitation1.58566242
39MP0003195_calcinosis1.58343230
40MP0002736_abnormal_nociception_after1.57943244
41MP0003786_premature_aging1.56282542
42MP0003646_muscle_fatigue1.53521895
43MP0008932_abnormal_embryonic_tissue1.47775277
44MP0004145_abnormal_muscle_electrophysio1.47554995
45MP0005551_abnormal_eye_electrophysiolog1.46407182
46MP0005253_abnormal_eye_physiology1.46112760
47MP0009780_abnormal_chondrocyte_physiolo1.45931723
48MP0000569_abnormal_digit_pigmentation1.45792066
49MP0005332_abnormal_amino_acid1.45199603
50MP0003880_abnormal_central_pattern1.43845772
51MP0001968_abnormal_touch/_nociception1.43692737
52MP0001986_abnormal_taste_sensitivity1.41197586
53MP0003567_abnormal_fetal_cardiomyocyte1.40416419
54MP0004130_abnormal_muscle_cell1.38734852
55MP0003787_abnormal_imprinting1.36349507
56MP0001529_abnormal_vocalization1.36339881
57MP0005584_abnormal_enzyme/coenzyme_acti1.33896506
58MP0002160_abnormal_reproductive_system1.31262370
59MP0001485_abnormal_pinna_reflex1.30845431
60MP0000631_abnormal_neuroendocrine_gland1.30412971
61MP0003890_abnormal_embryonic-extraembry1.29798629
62MP0003252_abnormal_bile_duct1.27608123
63MP0004142_abnormal_muscle_tone1.27079168
64MP0002089_abnormal_postnatal_growth/wei1.27078302
65MP0003123_paternal_imprinting1.26980636
66MP0005075_abnormal_melanosome_morpholog1.26710899
67MP0001905_abnormal_dopamine_level1.26436745
68MP0003937_abnormal_limbs/digits/tail_de1.25332145
69MP0006276_abnormal_autonomic_nervous1.25019113
70MP0000604_amyloidosis1.24644981
71MP0004924_abnormal_behavior1.24120640
72MP0005386_behavior/neurological_phenoty1.24120640
73MP0002734_abnormal_mechanical_nocicepti1.24082339
74MP0005083_abnormal_biliary_tract1.23164915
75MP0004808_abnormal_hematopoietic_stem1.22226003
76MP0008995_early_reproductive_senescence1.21354513
77MP0002063_abnormal_learning/memory/cond1.19116642
78MP0005266_abnormal_metabolism1.16057964
79MP0002210_abnormal_sex_determination1.16039652
80MP0002938_white_spotting1.15175722
81MP0001545_abnormal_hematopoietic_system1.15082735
82MP0005397_hematopoietic_system_phenotyp1.15082735
83MP0009745_abnormal_behavioral_response1.15051427
84MP0008007_abnormal_cellular_replicative1.14264687
85MP0005174_abnormal_tail_pigmentation1.13761176
86MP0003868_abnormal_feces_composition1.12951324
87MP0003111_abnormal_nucleus_morphology1.12874452
88MP0003119_abnormal_digestive_system1.12725529
89MP0005084_abnormal_gallbladder_morpholo1.11595418
90MP0005319_abnormal_enzyme/_coenzyme1.11495073
91MP0003186_abnormal_redox_activity1.11278966
92MP0003172_abnormal_lysosome_physiology1.10929351
93MP0000647_abnormal_sebaceous_gland1.10348497
94MP0001929_abnormal_gametogenesis1.08416713
95MP0001666_abnormal_nutrient_absorption1.07416558
96MP0005645_abnormal_hypothalamus_physiol1.06895061
97MP0004957_abnormal_blastocyst_morpholog1.06551495
98MP0002572_abnormal_emotion/affect_behav1.05375183
99MP0002735_abnormal_chemical_nociception1.04773344
100MP0003011_delayed_dark_adaptation1.04419090
101MP0002233_abnormal_nose_morphology1.04171671
102MP0001286_abnormal_eye_development1.02832068
103MP0001873_stomach_inflammation1.02810247
104MP0002332_abnormal_exercise_endurance1.02426201
105MP0004811_abnormal_neuron_physiology1.01729562
106MP0003121_genomic_imprinting1.01415831
107MP0005389_reproductive_system_phenotype1.00750023
108MP0003879_abnormal_hair_cell1.00246670
109MP0002638_abnormal_pupillary_reflex0.99876908
110MP0003077_abnormal_cell_cycle0.99761703
111MP0005535_abnormal_body_temperature0.99460841
112MP0002277_abnormal_respiratory_mucosa0.99442899
113MP0005376_homeostasis/metabolism_phenot0.98737815
114MP0003283_abnormal_digestive_organ0.97650298
115MP0010094_abnormal_chromosome_stability0.96074184
116MP0002751_abnormal_autonomic_nervous0.95427595
117MP0003724_increased_susceptibility_to0.94737026
118MP0002067_abnormal_sensory_capabilities0.93152787
119MP0001853_heart_inflammation0.93100584
120MP0000653_abnormal_sex_gland0.92291604
121MP0001145_abnormal_male_reproductive0.88504999
122MP0000427_abnormal_hair_cycle0.87669814
123MP0005423_abnormal_somatic_nervous0.86934067
124MP0005499_abnormal_olfactory_system0.86745872
125MP0005394_taste/olfaction_phenotype0.86745872
126MP0003941_abnormal_skin_development0.85784036
127MP0005391_vision/eye_phenotype0.85528036
128MP0002909_abnormal_adrenal_gland0.84571946
129MP0001984_abnormal_olfaction0.83387746
130MP0005195_abnormal_posterior_eye0.82864033
131MP0005636_abnormal_mineral_homeostasis0.82617778
132MP0000609_abnormal_liver_physiology0.81623827
133MP0002166_altered_tumor_susceptibility0.80812315
134MP0003698_abnormal_male_reproductive0.80308568
135MP0001293_anophthalmia0.80223022
136MP0000049_abnormal_middle_ear0.80166788
137MP0001119_abnormal_female_reproductive0.79719215
138MP0004134_abnormal_chest_morphology0.79435883
139MP0002064_seizures0.79211386
140MP0000372_irregular_coat_pigmentation0.78996808
141MP0002118_abnormal_lipid_homeostasis0.77165794
142MP0005448_abnormal_energy_balance0.76757449
143MP0002733_abnormal_thermal_nociception0.76555030
144MP0003191_abnormal_cellular_cholesterol0.76371794
145MP0009765_abnormal_xenobiotic_induced0.75017024
146MP0008872_abnormal_physiological_respon0.74870425
147MP0002272_abnormal_nervous_system0.74188827
148MP0003137_abnormal_impulse_conducting0.73163419
149MP0005171_absent_coat_pigmentation0.72908955
150MP0001324_abnormal_eye_pigmentation0.71866103
151MP0003638_abnormal_response/metabolism_0.71470066
152MP0003943_abnormal_hepatobiliary_system0.71402257
153MP0001915_intracranial_hemorrhage0.70744233
154MP0005646_abnormal_pituitary_gland0.70495828
155MP0001486_abnormal_startle_reflex0.70019569
156MP0004215_abnormal_myocardial_fiber0.69966485
157MP0002184_abnormal_innervation0.69616360
158MP0002837_dystrophic_cardiac_calcinosis0.69516279
159MP0000778_abnormal_nervous_system0.69103844
160MP0000383_abnormal_hair_follicle0.68749437
161MP0006292_abnormal_olfactory_placode0.68201005
162MP0009046_muscle_twitch0.66884835
163MP0006054_spinal_hemorrhage0.65438870
164MP0002084_abnormal_developmental_patter0.65414682
165MP0009250_abnormal_appendicular_skeleto0.63277731

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.29584443
2Hepatic necrosis (HP:0002605)4.17068645
3Hypobetalipoproteinemia (HP:0003563)3.87915851
4Increased CSF lactate (HP:0002490)3.72932404
5Mitochondrial inheritance (HP:0001427)3.70949713
6Increased hepatocellular lipid droplets (HP:0006565)3.68971169
7Lipid accumulation in hepatocytes (HP:0006561)3.61502030
8Molar tooth sign on MRI (HP:0002419)3.44906690
9Abnormality of midbrain morphology (HP:0002418)3.44906690
10Pancreatic cysts (HP:0001737)3.37752655
11Abnormal mitochondria in muscle tissue (HP:0008316)3.31555889
12Acute necrotizing encephalopathy (HP:0006965)3.27944021
13Hypoglycemic coma (HP:0001325)3.20303483
14Pancreatic fibrosis (HP:0100732)3.16543482
15Renal Fanconi syndrome (HP:0001994)3.05202391
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.02067995
17Respiratory difficulties (HP:0002880)3.01752296
18Increased intramyocellular lipid droplets (HP:0012240)2.98423590
19Cerebral edema (HP:0002181)2.96272262
20Methylmalonic aciduria (HP:0012120)2.95677569
21CNS demyelination (HP:0007305)2.92624510
22True hermaphroditism (HP:0010459)2.89651398
23Abnormality of the labia minora (HP:0012880)2.82767940
24Ketosis (HP:0001946)2.78120000
25Acute encephalopathy (HP:0006846)2.78097315
26Nephronophthisis (HP:0000090)2.76429355
27Colon cancer (HP:0003003)2.75406795
28Increased muscle lipid content (HP:0009058)2.75281577
29Truncal ataxia (HP:0002078)2.72245454
30Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70653702
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70535561
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70535561
33Increased serum lactate (HP:0002151)2.67284972
34Lactic acidosis (HP:0003128)2.65250331
35Neurodegeneration (HP:0002180)2.62984900
36Abnormality of the pons (HP:0007361)2.61957750
37Ketoacidosis (HP:0001993)2.61609274
38Progressive macrocephaly (HP:0004481)2.60023933
39Methylmalonic acidemia (HP:0002912)2.57133295
40Emotional lability (HP:0000712)2.53863107
41Abnormality of alanine metabolism (HP:0010916)2.51908611
42Hyperalaninemia (HP:0003348)2.51908611
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51908611
44Dicarboxylic aciduria (HP:0003215)2.48390112
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48390112
46Optic disc pallor (HP:0000543)2.42762716
473-Methylglutaconic aciduria (HP:0003535)2.42467099
48Hyperlipoproteinemia (HP:0010980)2.42077659
49Hyperglycinemia (HP:0002154)2.40315735
50Abnormality of serum amino acid levels (HP:0003112)2.38354218
51Toxemia of pregnancy (HP:0100603)2.37393597
52Generalized aminoaciduria (HP:0002909)2.36233817
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.34057833
54Abnormality of methionine metabolism (HP:0010901)2.32468037
55Intrahepatic cholestasis (HP:0001406)2.32053378
56Abnormality of chromosome stability (HP:0003220)2.28892376
57Abnormality of the ileum (HP:0001549)2.28783454
58Meckel diverticulum (HP:0002245)2.27307105
59Birth length less than 3rd percentile (HP:0003561)2.26281349
60Delayed CNS myelination (HP:0002188)2.23585063
61Gliosis (HP:0002171)2.23575492
62Reduced subcutaneous adipose tissue (HP:0003758)2.23263888
63Absent eyelashes (HP:0000561)2.22788817
64Abnormality of the renal medulla (HP:0100957)2.21374734
65Spastic diplegia (HP:0001264)2.20945397
66Congenital, generalized hypertrichosis (HP:0004540)2.19458295
67Lethargy (HP:0001254)2.19199178
68Chronic hepatic failure (HP:0100626)2.18564842
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17841932
70Absent hair (HP:0002298)2.17306442
71Septo-optic dysplasia (HP:0100842)2.15728330
72Global brain atrophy (HP:0002283)2.14570627
73Abnormal tarsal ossification (HP:0008369)2.14312143
74Hypolipoproteinemia (HP:0010981)2.13419862
75Delusions (HP:0000746)2.13408305
76Neuroendocrine neoplasm (HP:0100634)2.11087256
77Sclerocornea (HP:0000647)2.11050716
78Exercise intolerance (HP:0003546)2.10417354
79Chromsome breakage (HP:0040012)2.10294847
80Pheochromocytoma (HP:0002666)2.10276148
81Abnormality of serine family amino acid metabolism (HP:0010894)2.08597778
82Abnormality of glycine metabolism (HP:0010895)2.08597778
83Optic nerve hypoplasia (HP:0000609)2.08362808
84Protruding tongue (HP:0010808)2.07953802
85Exertional dyspnea (HP:0002875)2.07270055
86Reticulocytopenia (HP:0001896)2.07160318
87Abnormality of the renal cortex (HP:0011035)2.05946298
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05686468
89Abnormality of urine glucose concentration (HP:0011016)2.05385795
90Glycosuria (HP:0003076)2.05385795
91Bile duct proliferation (HP:0001408)2.05212685
92Abnormal biliary tract physiology (HP:0012439)2.05212685
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04335688
94Leukodystrophy (HP:0002415)2.04180928
95Hyperglycinuria (HP:0003108)2.02242139
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01401983
97Medial flaring of the eyebrow (HP:0010747)2.01155908
98Congenital stationary night blindness (HP:0007642)2.00600711
99Renal cortical cysts (HP:0000803)2.00211890
100Rough bone trabeculation (HP:0100670)1.99472713
101Intestinal atresia (HP:0011100)1.95567428
102Epileptiform EEG discharges (HP:0011182)1.92946930
10311 pairs of ribs (HP:0000878)1.92617210
104Aplastic anemia (HP:0001915)1.92431660
105Aplasia/Hypoplasia of the tongue (HP:0010295)1.92409919
106Impaired smooth pursuit (HP:0007772)1.92334299
107Abnormality of cells of the erythroid lineage (HP:0012130)1.92320520
108Abnormality of renal resorption (HP:0011038)1.92197003
109Abolished electroretinogram (ERG) (HP:0000550)1.90772858
110Abnormal number of erythroid precursors (HP:0012131)1.89085354
111Absent thumb (HP:0009777)1.88959160
112Respiratory failure (HP:0002878)1.88727033
113Anencephaly (HP:0002323)1.87892284
114Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87834170
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87761422
116EEG with generalized epileptiform discharges (HP:0011198)1.86815044
117Hypsarrhythmia (HP:0002521)1.86421692
118Gastrointestinal atresia (HP:0002589)1.86069351
119Hyperammonemia (HP:0001987)1.85988745
120Pendular nystagmus (HP:0012043)1.84777943
121Ragged-red muscle fibers (HP:0003200)1.84700549
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.84045342
123Microglossia (HP:0000171)1.83847982
124Triphalangeal thumb (HP:0001199)1.81974715
125Duodenal stenosis (HP:0100867)1.81909935
126Small intestinal stenosis (HP:0012848)1.81909935
127Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81221923
128Abnormality of sulfur amino acid metabolism (HP:0004339)1.81021478
129Abnormality of the intrinsic pathway (HP:0010989)1.79793118
130Unsteady gait (HP:0002317)1.79282266
131Hepatoblastoma (HP:0002884)1.77951714
132Hyperbilirubinemia (HP:0002904)1.77907355
133Fat malabsorption (HP:0002630)1.77274778
134Metabolic acidosis (HP:0001942)1.76362362
135Abnormality of glycolysis (HP:0004366)1.75586379
136Increased serum pyruvate (HP:0003542)1.75586379
137Hypothermia (HP:0002045)1.75268364
138Microretrognathia (HP:0000308)1.74589639
139Abnormality of the preputium (HP:0100587)1.74537585
140Absent septum pellucidum (HP:0001331)1.74062923
141Volvulus (HP:0002580)1.74046467
142Megaloblastic anemia (HP:0001889)1.73981128
143Supernumerary spleens (HP:0009799)1.73709593
144Abnormal lung lobation (HP:0002101)1.73360296
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72436598
146Acanthocytosis (HP:0001927)1.72404595
147Male pseudohermaphroditism (HP:0000037)1.72368623
148Macrocytic anemia (HP:0001972)1.72106868
149Abnormality of the duodenum (HP:0002246)1.71756189
150Hypoplasia of the pons (HP:0012110)1.71624540
151Type I transferrin isoform profile (HP:0003642)1.71288115
152Tubular atrophy (HP:0000092)1.70013766
153Postaxial foot polydactyly (HP:0001830)1.69986376
154Type 2 muscle fiber atrophy (HP:0003554)1.67574949
155Short tibia (HP:0005736)1.67066533
156Oligodactyly (hands) (HP:0001180)1.65791505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.14242570
2EIF2AK13.61978855
3CAMKK23.45283532
4CDK83.20344181
5SCYL22.87407105
6VRK22.82707315
7TRIM282.61553815
8WNK32.60933348
9MAP4K22.53522518
10EIF2AK32.53305057
11MST42.47553185
12ERBB32.43769495
13MKNK12.26309486
14BMPR1B2.23772659
15BCKDK2.19257462
16WEE12.05806300
17BUB12.01009274
18PLK41.99261939
19CDC71.99090255
20TLK11.93932105
21MINK11.89066844
22BRSK21.87990601
23STK161.86855164
24FLT31.82720839
25CSNK1G21.81317919
26MAP3K41.76121328
27LMTK21.75970057
28MARK11.70871138
29BRAF1.68654558
30PBK1.66209192
31ADRBK21.64680665
32CSNK1G31.63842846
33INSRR1.63301656
34MAP3K71.56152359
35SGK21.49997957
36TTK1.49360540
37TAF11.43683414
38SRPK11.43282730
39MAP2K71.42805055
40DAPK11.39474522
41GRK11.31407947
42MUSK1.31004550
43TNIK1.30850886
44TGFBR11.30414716
45MAP3K121.27132207
46NME11.26055071
47PLK21.25892971
48PDK21.25783174
49OBSCN1.25288709
50YES11.24504439
51BCR1.24453743
52CAMKK11.19164058
53PNCK1.13188497
54WNK41.10787218
55BRSK11.09054748
56VRK11.08488870
57CSNK1G11.07255905
58NEK11.05952950
59PKN21.04166408
60DYRK20.99219016
61PINK10.98784981
62ACVR1B0.97971150
63NTRK20.97890937
64CASK0.96544628
65ZAK0.96239364
66NTRK30.94994889
67OXSR10.94624749
68MAPK130.91854739
69BRD40.90517696
70EPHA40.90464144
71MAPKAPK50.89074463
72DYRK30.87926441
73KIT0.87166256
74STK390.86309804
75TEC0.86207006
76DYRK1B0.83965647
77NUAK10.83572296
78ERN10.82716018
79FRK0.82119679
80TXK0.80712222
81TIE10.80487741
82PASK0.80081930
83MAP2K40.79977352
84TSSK60.77365600
85LIMK10.76269697
86MAP2K60.75185491
87SGK2230.73820600
88SGK4940.73820600
89PLK30.71414317
90CSNK1A1L0.69711085
91PRKG20.69645909
92PRKCG0.68489058
93MAP3K90.67293872
94SGK30.65721934
95PAK30.65427646
96PIM20.64827672
97PDK40.64688466
98PDK30.64688466
99AURKB0.61721107
100DAPK20.60993834
101PLK10.59952084
102CCNB10.59909230
103ADRBK10.59591627
104NLK0.57910136
105DYRK1A0.57407866
106FGFR10.56738287
107RPS6KB10.56554868
108STK38L0.55420004
109ATR0.55129810
110TAOK20.54582510
111STK30.53768572
112ATM0.51327130
113CHEK20.51254161
114TESK20.50694017
115CAMK10.49677611
116PRKCE0.47498558
117CSNK2A20.45559590
118EIF2AK20.43997831
119LRRK20.43772683
120ILK0.43502699
121PHKG10.42550882
122PHKG20.42550882
123CDK50.41924626
124GRK50.41892700
125CSNK2A10.41203056
126STK40.38111718
127ARAF0.36603565
128PIK3CA0.36470217
129PRKG10.36180724
130MAP3K50.35927332
131RPS6KA50.35672006
132CHEK10.35054647
133NEK20.34271298
134PRKACG0.33974493
135MAPK40.33284106
136AURKA0.33061154
137SYK0.33050624
138CDK140.32397633
139CDK190.32150368
140MKNK20.31031761
141RPS6KB20.30663183
142GRK60.30651893
143CSNK1A10.30632903
144TAOK10.29554060
145CDK30.28399666
146CSNK1E0.28339556
147PRKCI0.28164766
148CDK180.27614233
149PRKACB0.27512918
150TAOK30.26910954
151CAMK2A0.26803845
152PRKD30.26411021
153TNK20.25779972

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.30967733
2Sulfur metabolism_Homo sapiens_hsa009202.91100101
3Ribosome_Homo sapiens_hsa030102.72833528
4Nitrogen metabolism_Homo sapiens_hsa009102.61958118
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54353615
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.35334353
7Cysteine and methionine metabolism_Homo sapiens_hsa002702.27003444
8Basal transcription factors_Homo sapiens_hsa030222.22026795
9Non-homologous end-joining_Homo sapiens_hsa034502.18888703
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12465327
11Fanconi anemia pathway_Homo sapiens_hsa034602.01942461
12Parkinsons disease_Homo sapiens_hsa050121.96994842
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89245755
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88797272
15Protein export_Homo sapiens_hsa030601.88211675
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77334699
17N-Glycan biosynthesis_Homo sapiens_hsa005101.75322074
18Biosynthesis of amino acids_Homo sapiens_hsa012301.73354603
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69037610
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68255917
21Propanoate metabolism_Homo sapiens_hsa006401.63104363
22Pyruvate metabolism_Homo sapiens_hsa006201.62258974
23Oxidative phosphorylation_Homo sapiens_hsa001901.59326632
24Fatty acid degradation_Homo sapiens_hsa000711.57244718
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52172707
26Carbon metabolism_Homo sapiens_hsa012001.52086266
27Nicotine addiction_Homo sapiens_hsa050331.48035288
28DNA replication_Homo sapiens_hsa030301.47059232
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45000915
30Fructose and mannose metabolism_Homo sapiens_hsa000511.44895275
31RNA transport_Homo sapiens_hsa030131.43904753
32Butanoate metabolism_Homo sapiens_hsa006501.43836483
33Cardiac muscle contraction_Homo sapiens_hsa042601.43305202
34Peroxisome_Homo sapiens_hsa041461.41499846
35RNA polymerase_Homo sapiens_hsa030201.41111342
36Alzheimers disease_Homo sapiens_hsa050101.39861083
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.39728696
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38592870
39Pyrimidine metabolism_Homo sapiens_hsa002401.38080898
40Spliceosome_Homo sapiens_hsa030401.37817584
41Pentose phosphate pathway_Homo sapiens_hsa000301.37418176
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37017380
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31261078
44Homologous recombination_Homo sapiens_hsa034401.30148811
45Huntingtons disease_Homo sapiens_hsa050161.30100983
46Phototransduction_Homo sapiens_hsa047441.28336158
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24971483
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24490484
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17022243
50Fatty acid metabolism_Homo sapiens_hsa012121.15650099
51Nucleotide excision repair_Homo sapiens_hsa034201.14765410
52Selenocompound metabolism_Homo sapiens_hsa004501.14026569
53Mismatch repair_Homo sapiens_hsa034301.09844526
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07814407
55Folate biosynthesis_Homo sapiens_hsa007901.07350146
56Caffeine metabolism_Homo sapiens_hsa002321.02837546
57Galactose metabolism_Homo sapiens_hsa000521.01599020
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96776927
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95630257
60Tryptophan metabolism_Homo sapiens_hsa003800.94745555
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93190687
62Sulfur relay system_Homo sapiens_hsa041220.93130704
63Base excision repair_Homo sapiens_hsa034100.92458590
64Steroid biosynthesis_Homo sapiens_hsa001000.92425615
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.90903257
66Arginine biosynthesis_Homo sapiens_hsa002200.90363068
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89888339
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89366747
69Fatty acid elongation_Homo sapiens_hsa000620.88575455
70RNA degradation_Homo sapiens_hsa030180.85794073
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85261897
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81420930
73Purine metabolism_Homo sapiens_hsa002300.80215262
74One carbon pool by folate_Homo sapiens_hsa006700.80133351
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78509943
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78418642
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76851284
78Synaptic vesicle cycle_Homo sapiens_hsa047210.75891550
79Linoleic acid metabolism_Homo sapiens_hsa005910.74392775
80Metabolic pathways_Homo sapiens_hsa011000.74337430
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70757772
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67974764
83Glutathione metabolism_Homo sapiens_hsa004800.65956961
84Dopaminergic synapse_Homo sapiens_hsa047280.64550395
85Cell cycle_Homo sapiens_hsa041100.64117984
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61485700
87Regulation of autophagy_Homo sapiens_hsa041400.60297213
88Circadian entrainment_Homo sapiens_hsa047130.59595910
89Long-term potentiation_Homo sapiens_hsa047200.59477775
90GABAergic synapse_Homo sapiens_hsa047270.58945150
91Retinol metabolism_Homo sapiens_hsa008300.58764772
92PPAR signaling pathway_Homo sapiens_hsa033200.58265050
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57808370
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56792465
95Alcoholism_Homo sapiens_hsa050340.56773831
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56056410
97mRNA surveillance pathway_Homo sapiens_hsa030150.54643500
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54623773
99Lysine degradation_Homo sapiens_hsa003100.53870910
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53558932
101p53 signaling pathway_Homo sapiens_hsa041150.53208180
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52101566
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.52066023
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49585209
105Oocyte meiosis_Homo sapiens_hsa041140.47600160
106Complement and coagulation cascades_Homo sapiens_hsa046100.46421187
107Chemical carcinogenesis_Homo sapiens_hsa052040.46414992
108Olfactory transduction_Homo sapiens_hsa047400.45290542
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44798805
110Glutamatergic synapse_Homo sapiens_hsa047240.43062192
111Ether lipid metabolism_Homo sapiens_hsa005650.42954222
112beta-Alanine metabolism_Homo sapiens_hsa004100.42625870
113Vitamin B6 metabolism_Homo sapiens_hsa007500.41329206
114Amphetamine addiction_Homo sapiens_hsa050310.40140861
115Basal cell carcinoma_Homo sapiens_hsa052170.38328333
116Phenylalanine metabolism_Homo sapiens_hsa003600.37888756
117Systemic lupus erythematosus_Homo sapiens_hsa053220.37799577
118Primary immunodeficiency_Homo sapiens_hsa053400.36649909
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.36617426
120Taste transduction_Homo sapiens_hsa047420.35800171
121Tyrosine metabolism_Homo sapiens_hsa003500.35697893
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32896164
123Hedgehog signaling pathway_Homo sapiens_hsa043400.32236749
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31853625
125TGF-beta signaling pathway_Homo sapiens_hsa043500.31788611
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31262087
127Starch and sucrose metabolism_Homo sapiens_hsa005000.30774549
128Collecting duct acid secretion_Homo sapiens_hsa049660.28850930
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27591188
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24461323
131Vitamin digestion and absorption_Homo sapiens_hsa049770.22829305
132Arginine and proline metabolism_Homo sapiens_hsa003300.21555946
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19986154
134Arachidonic acid metabolism_Homo sapiens_hsa005900.19337995
135Fat digestion and absorption_Homo sapiens_hsa049750.16641975

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