GTSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.82857091
2sperm motility (GO:0030317)9.70602977
3multicellular organism reproduction (GO:0032504)9.45778287
4sperm-egg recognition (GO:0035036)9.25552030
5binding of sperm to zona pellucida (GO:0007339)8.88174122
6male meiosis (GO:0007140)8.69542593
7synaptonemal complex assembly (GO:0007130)8.55502433
8cell wall macromolecule metabolic process (GO:0044036)8.39215970
9cell wall macromolecule catabolic process (GO:0016998)8.39215970
10synaptonemal complex organization (GO:0070193)8.37576994
11cell-cell recognition (GO:0009988)8.25730589
12cilium or flagellum-dependent cell motility (GO:0001539)8.22847413
13acrosome assembly (GO:0001675)8.14560268
14DNA methylation involved in gamete generation (GO:0043046)8.03989884
15reproduction (GO:0000003)7.81968245
16acrosome reaction (GO:0007340)7.78184686
17spermatid development (GO:0007286)7.60893180
18axonemal dynein complex assembly (GO:0070286)7.52460880
19epithelial cilium movement (GO:0003351)7.42322711
20plasma membrane fusion (GO:0045026)7.41188237
21motile cilium assembly (GO:0044458)6.65832097
22regulation of cilium movement (GO:0003352)6.36234889
23single fertilization (GO:0007338)6.24376525
24cilium movement (GO:0003341)6.19579046
25chromosome organization involved in meiosis (GO:0070192)6.06937402
26male meiosis I (GO:0007141)6.01659314
27meiotic nuclear division (GO:0007126)5.88670301
28fertilization (GO:0009566)5.80045665
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.74352593
30spermatogenesis (GO:0007283)5.56666890
31male gamete generation (GO:0048232)5.55330452
32microtubule depolymerization (GO:0007019)5.47260127
33gamete generation (GO:0007276)5.27154586
34sperm capacitation (GO:0048240)5.14853419
35meiosis I (GO:0007127)5.13957664
36negative regulation of inclusion body assembly (GO:0090084)5.10191783
37germ cell development (GO:0007281)4.98109992
38DNA replication checkpoint (GO:0000076)4.88523489
39meiotic cell cycle (GO:0051321)4.87930733
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.72118885
41microtubule severing (GO:0051013)4.68390455
42gene silencing by RNA (GO:0031047)4.60748235
43chromosome condensation (GO:0030261)4.48425085
44regulation of meiosis I (GO:0060631)4.41427428
45meiotic cell cycle process (GO:1903046)4.36116839
46DNA packaging (GO:0006323)4.31818710
47regulation of inclusion body assembly (GO:0090083)4.24764787
48proteasome assembly (GO:0043248)4.20526143
49multicellular organismal reproductive process (GO:0048609)4.11673905
50DNA strand elongation involved in DNA replication (GO:0006271)4.00463062
51telomere maintenance via semi-conservative replication (GO:0032201)3.98742805
52organic cation transport (GO:0015695)3.96092804
53monoubiquitinated protein deubiquitination (GO:0035520)3.91488725
54DNA replication initiation (GO:0006270)3.90656168
55DNA strand elongation (GO:0022616)3.86518552
56DNA alkylation (GO:0006305)3.80578051
57DNA methylation (GO:0006306)3.80578051
58positive regulation of histone H3-K4 methylation (GO:0051571)3.80163817
59formation of translation preinitiation complex (GO:0001731)3.78722229
60cell recognition (GO:0008037)3.71545739
61folic acid-containing compound biosynthetic process (GO:0009396)3.70398962
62protein localization to chromosome, centromeric region (GO:0071459)3.69669096
63mitotic nuclear envelope disassembly (GO:0007077)3.69581119
64regulation of microtubule-based movement (GO:0060632)3.68229418
65ventricular system development (GO:0021591)3.64082202
66regulation of spindle checkpoint (GO:0090231)3.63838784
67histone exchange (GO:0043486)3.61880471
68purine nucleobase biosynthetic process (GO:0009113)3.61116418
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59374775
70seminiferous tubule development (GO:0072520)3.57093170
71telomere maintenance via recombination (GO:0000722)3.56584274
72protein polyglutamylation (GO:0018095)3.53354698
73CENP-A containing nucleosome assembly (GO:0034080)3.50791199
74protein K6-linked ubiquitination (GO:0085020)3.50766549
75mitotic sister chromatid cohesion (GO:0007064)3.47583617
76IMP biosynthetic process (GO:0006188)3.47259128
77regulation of acrosome reaction (GO:0060046)3.47124795
78single strand break repair (GO:0000012)3.46405284
79synapsis (GO:0007129)3.46367672
80gene silencing (GO:0016458)3.45765119
81mitotic recombination (GO:0006312)3.45412457
82ribosome assembly (GO:0042255)3.44616980
83spermatid nucleus differentiation (GO:0007289)3.40758960
84resolution of meiotic recombination intermediates (GO:0000712)3.36519711
85regulation of histone H3-K4 methylation (GO:0051569)3.36144093
86membrane disassembly (GO:0030397)3.36059204
87nuclear envelope disassembly (GO:0051081)3.36059204
88calcium ion-dependent exocytosis (GO:0017156)3.33560090
89sister chromatid segregation (GO:0000819)3.33230953
90oxidative phosphorylation (GO:0006119)3.32608682
91rRNA modification (GO:0000154)3.30866840
92chaperone-mediated protein complex assembly (GO:0051131)3.30775059
93regulation of centriole replication (GO:0046599)3.28577121
94nucleobase biosynthetic process (GO:0046112)3.28395669
95oogenesis (GO:0048477)3.28160331
96chromatin remodeling at centromere (GO:0031055)3.28043873
97female gamete generation (GO:0007292)3.27420920
98rRNA methylation (GO:0031167)3.24253465
99sister chromatid cohesion (GO:0007062)3.23502125
100DNA unwinding involved in DNA replication (GO:0006268)3.23457102
101protoporphyrinogen IX metabolic process (GO:0046501)3.23367249
102protoporphyrinogen IX biosynthetic process (GO:0006782)3.22402381
103maturation of 5.8S rRNA (GO:0000460)3.21412696
104pore complex assembly (GO:0046931)3.21081979
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.20575033
106microtubule polymerization or depolymerization (GO:0031109)3.20109732
107nuclear pore complex assembly (GO:0051292)3.19028355
108regulation of translational fidelity (GO:0006450)3.15931887
109reciprocal DNA recombination (GO:0035825)3.15247124
110reciprocal meiotic recombination (GO:0007131)3.15247124
111DNA replication-dependent nucleosome organization (GO:0034723)3.14954879
112DNA replication-dependent nucleosome assembly (GO:0006335)3.14954879
113metaphase plate congression (GO:0051310)3.13481680
114chromosome segregation (GO:0007059)3.13278105
115DNA topological change (GO:0006265)3.12797978
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12387089
117mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12289714
118regulation of histone H3-K9 methylation (GO:0051570)3.12253181
119gonadal mesoderm development (GO:0007506)3.11594693
120ribosomal small subunit assembly (GO:0000028)3.11262100
121mitotic metaphase plate congression (GO:0007080)3.09968249
122ribosome biogenesis (GO:0042254)3.09543576
123multicellular organismal development (GO:0007275)3.08127491
124regulation of DNA methylation (GO:0044030)3.07690104
125meiotic chromosome segregation (GO:0045132)3.07645470
126protein localization to kinetochore (GO:0034501)3.04034948
127ribosomal large subunit biogenesis (GO:0042273)3.04030821
128oocyte development (GO:0048599)3.02392161
129tetrahydrofolate metabolic process (GO:0046653)3.02151937
130kinetochore organization (GO:0051383)3.00876448
131attachment of spindle microtubules to kinetochore (GO:0008608)3.00803114
132positive regulation of chromosome segregation (GO:0051984)3.00300078
133negative regulation of organelle assembly (GO:1902116)2.99623104
134glycerol ether metabolic process (GO:0006662)2.98405131
135DNA catabolic process, exonucleolytic (GO:0000738)2.96933624
136tRNA aminoacylation for protein translation (GO:0006418)2.96246679
137centriole assembly (GO:0098534)2.95996563
138pseudouridine synthesis (GO:0001522)2.95902803
139regulation of chromosome segregation (GO:0051983)2.95589152
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95349231
141regulation of female gonad development (GO:2000194)2.94950584
142oocyte maturation (GO:0001556)2.94107862
143nucleus organization (GO:0006997)2.93587416
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93530871
145mitotic chromosome condensation (GO:0007076)2.91658142
146DNA methylation or demethylation (GO:0044728)2.91253159
147telomere maintenance via telomere lengthening (GO:0010833)2.90099872
148amino acid activation (GO:0043038)2.89497440
149tRNA aminoacylation (GO:0043039)2.89497440
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89176106
151pteridine-containing compound biosynthetic process (GO:0042559)2.89167760
152replication fork processing (GO:0031297)2.87255807
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.87136435
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87136435
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87136435
156DNA replication-independent nucleosome organization (GO:0034724)2.86980143
157DNA replication-independent nucleosome assembly (GO:0006336)2.86980143
158regulation of centrosome cycle (GO:0046605)2.86008828
159negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85870347
160positive regulation of ligase activity (GO:0051351)2.85165549
161mitotic sister chromatid segregation (GO:0000070)2.84937100
162positive regulation of histone methylation (GO:0031062)2.84792194
163transcription-coupled nucleotide-excision repair (GO:0006283)2.84610445
164nuclear pore organization (GO:0006999)2.83930459
165transcription from mitochondrial promoter (GO:0006390)2.83439586
166IMP metabolic process (GO:0046040)2.82808068
167terpenoid biosynthetic process (GO:0016114)2.82787507
168ribonucleoprotein complex biogenesis (GO:0022613)2.82474392
169negative regulation of meiosis (GO:0045835)2.81578296
170centriole replication (GO:0007099)2.81442863
171positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81393917
172chromosome organization (GO:0051276)2.80916659
173rRNA processing (GO:0006364)2.80778134
174genitalia morphogenesis (GO:0035112)2.80384134
175protein localization to chromosome (GO:0034502)2.75825881
176piRNA metabolic process (GO:0034587)11.6342059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.50159732
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.61395226
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54897241
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47443511
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.43329352
6EZH2_22144423_ChIP-Seq_EOC_Human3.15965103
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.10649049
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00719430
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.89047762
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81004268
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75301030
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.69677632
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63135166
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55093728
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52680518
16VDR_23849224_ChIP-Seq_CD4+_Human2.46970398
17FOXP3_21729870_ChIP-Seq_TREG_Human2.38693378
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34969392
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33393885
20DCP1A_22483619_ChIP-Seq_HELA_Human2.33013435
21KAP1_22055183_ChIP-Seq_ESCs_Mouse2.32970901
22ELK1_19687146_ChIP-ChIP_HELA_Human2.29230876
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27049479
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22946035
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22786869
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18142927
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.14803685
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12192464
29E2F7_22180533_ChIP-Seq_HELA_Human2.03514469
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01075725
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2316870
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99621369
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95409942
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93532757
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92985486
36* GATA1_26923725_Chip-Seq_HPCs_Mouse1.92465273
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.91891218
38TTF2_22483619_ChIP-Seq_HELA_Human1.89663367
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87940947
40GABP_19822575_ChIP-Seq_HepG2_Human1.86323285
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84803670
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81891404
43VDR_22108803_ChIP-Seq_LS180_Human1.81132622
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.77173031
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.77165530
46XRN2_22483619_ChIP-Seq_HELA_Human1.73024141
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67930202
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67403299
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66218516
50AR_21909140_ChIP-Seq_LNCAP_Human1.65982354
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63441098
52KDM5A_27292631_Chip-Seq_BREAST_Human1.63261980
53STAT1_17558387_ChIP-Seq_HELA_Human1.61625028
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60917175
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59301596
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58361313
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55323502
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53289452
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52330222
60* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47780133
61GATA3_21867929_ChIP-Seq_TH1_Mouse1.47578765
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46998535
63GATA3_21867929_ChIP-Seq_CD8_Mouse1.41494060
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.40309366
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33594176
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32291679
67MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30689184
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30336581
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29522108
70SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.29463854
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27908112
72* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.27674979
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27486146
74MYC_18940864_ChIP-ChIP_HL60_Human1.25358314
75* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23317943
76* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.22551634
77* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21561110
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21257344
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20410817
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20071952
81GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.20011234
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.19068293
83NCOR1_26117541_ChIP-Seq_K562_Human1.18421749
84CIITA_25753668_ChIP-Seq_RAJI_Human1.16370196
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.16316640
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15508046
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15048446
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14356176
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14159522
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13643587
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13023242
92GATA1_22025678_ChIP-Seq_K562_Human1.12233918
93ZNF274_21170338_ChIP-Seq_K562_Hela1.10275874
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09524489
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08668343
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.07177996
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05782367
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05528929
99LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05436007
100ERG_20517297_ChIP-Seq_VCAP_Human1.04931835
101* SPI1_26923725_Chip-Seq_HPCs_Mouse1.04920541
102* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04717044
103P53_21459846_ChIP-Seq_SAOS-2_Human1.04704901
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04570920
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03079091
106LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.02420314
107ESET_19884257_ChIP-Seq_ESCs_Mouse1.02415879
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01647203
109* RNF2_27304074_Chip-Seq_NSC_Mouse1.00697246
110* TAL1_26923725_Chip-Seq_HPCs_Mouse1.00348768
111IRF1_19129219_ChIP-ChIP_H3396_Human0.99563229
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98796671
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98583977
114* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98015122
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96340141
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95757540
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.94591327
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94373435
119TFEB_21752829_ChIP-Seq_HELA_Human0.93825478
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93250866
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93167283
122KDM2B_26808549_Chip-Seq_REH_Human0.92916692
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.91771348
124* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91157896
125OCT4_18555785_Chip-Seq_ESCs_Mouse0.89421188
126KLF4_18555785_Chip-Seq_ESCs_Mouse0.88560741
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88094073
128NANOG_20526341_ChIP-Seq_ESCs_Human0.87689609
129NFYB_21822215_ChIP-Seq_K562_Human0.87400856
130ETV1_20927104_ChIP-Seq_GIST48_Human0.87322381
131PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87297491
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86941358
133* FLI1_21867929_ChIP-Seq_CD8_Mouse0.85788085
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85045997
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84990556
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84966266
137ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84624219
138NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84407700
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84382032
140* GF1_26923725_Chip-Seq_HPCs_Mouse0.84324663
141ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84211646
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83835692
143* RARA_24833708_ChIP-Seq_LIVER_Mouse0.83816447
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83356481
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.83278160
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83188127
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82824153
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82812028
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82743665
150FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82270259
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81946036
152CBP_20019798_ChIP-Seq_JUKART_Human0.81946036
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81334695
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.81116351
155STAT3_18555785_ChIP-Seq_MESCs_Mouse0.80675378
156SOX2_21211035_ChIP-Seq_LN229_Human0.80639837
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.80613237
158SCL_19346495_ChIP-Seq_HPC-7_Human0.80384769
159RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80100453
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79980148
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.79933940
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79233210
163PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79047709
164TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78096611
165TP53_22573176_ChIP-Seq_HFKS_Human0.77768590
166SALL4_22934838_ChIP-ChIP_CD34+_Human0.77491766
167* SPI1_23547873_ChIP-Seq_NB4_Human0.76392972
168CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75859488
169CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70432877
170PHF8_20622853_ChIP-Seq_HELA_Human0.70247842
171MYB_26560356_Chip-Seq_TH2_Human0.69894421
172KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69833427
173ELK1_22589737_ChIP-Seq_MCF10A_Human0.69041456
174GATA6_21074721_ChIP-Seq_CACO-2_Human0.68736179
175RBPJ_21746931_ChIP-Seq_IB4_Human0.68199536
176GATA1_19941826_ChIP-Seq_K562_Human0.67649209
177GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.67636544
178CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66531963
179STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66173649
180CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.65517516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.94194505
2* MP0001929_abnormal_gametogenesis5.54544172
3* MP0003698_abnormal_male_reproductive5.13917511
4* MP0002210_abnormal_sex_determination4.15851789
5* MP0001145_abnormal_male_reproductive3.38567902
6MP0004147_increased_porphyrin_level3.30222434
7* MP0000653_abnormal_sex_gland3.29188567
8* MP0002161_abnormal_fertility/fecundity3.22963105
9MP0010094_abnormal_chromosome_stability3.06327399
10MP0003718_maternal_effect2.83564821
11MP0002653_abnormal_ependyma_morphology2.81479896
12MP0003693_abnormal_embryo_hatching2.77312553
13MP0003646_muscle_fatigue2.70013252
14MP0003111_abnormal_nucleus_morphology2.59077828
15MP0008058_abnormal_DNA_repair2.48428865
16MP0003806_abnormal_nucleotide_metabolis2.46256602
17MP0003077_abnormal_cell_cycle2.03037278
18MP0005410_abnormal_fertilization11.4088261
19MP0008995_early_reproductive_senescence1.97034447
20MP0004957_abnormal_blastocyst_morpholog1.97015844
21MP0005670_abnormal_white_adipose1.87024800
22MP0008057_abnormal_DNA_replication1.82281099
23MP0000372_irregular_coat_pigmentation1.76874829
24MP0003786_premature_aging1.73380438
25MP0002160_abnormal_reproductive_system1.69571552
26MP0002396_abnormal_hematopoietic_system1.67448965
27MP0001119_abnormal_female_reproductive1.64406892
28MP0003699_abnormal_female_reproductive1.64037660
29MP0003186_abnormal_redox_activity1.63245437
30MP0003656_abnormal_erythrocyte_physiolo1.52565057
31MP0000678_abnormal_parathyroid_gland1.35649277
32MP0005389_reproductive_system_phenotype1.31659064
33MP0001730_embryonic_growth_arrest1.30919089
34MP0008007_abnormal_cellular_replicative1.30320417
35MP0008932_abnormal_embryonic_tissue1.29751533
36MP0005083_abnormal_biliary_tract1.29136121
37MP0005395_other_phenotype1.20018620
38MP0005360_urolithiasis1.14830142
39MP0003123_paternal_imprinting1.10048016
40MP0005623_abnormal_meninges_morphology1.07308839
41MP0001873_stomach_inflammation1.02896791
42MP0005408_hypopigmentation1.02203002
43MP0002132_abnormal_respiratory_system0.99168004
44MP0002282_abnormal_trachea_morphology0.97969006
45MP0009333_abnormal_splenocyte_physiolog0.95348360
46MP0002139_abnormal_hepatobiliary_system0.94377848
47MP0002095_abnormal_skin_pigmentation0.94195176
48MP0005647_abnormal_sex_gland0.91727607
49MP0000703_abnormal_thymus_morphology0.91454840
50MP0005451_abnormal_body_composition0.90969208
51MP0004233_abnormal_muscle_weight0.90848374
52MP0001672_abnormal_embryogenesis/_devel0.90785159
53MP0005380_embryogenesis_phenotype0.90785159
54MP0002102_abnormal_ear_morphology0.87465689
55MP0003315_abnormal_perineum_morphology0.86771895
56MP0000350_abnormal_cell_proliferation0.86540650
57MP0001881_abnormal_mammary_gland0.85965977
58MP0002138_abnormal_hepatobiliary_system0.84537225
59MP0008789_abnormal_olfactory_epithelium0.83892687
60MP0008775_abnormal_heart_ventricle0.83862656
61MP0002085_abnormal_embryonic_tissue0.82109057
62MP0001697_abnormal_embryo_size0.82065045
63MP0004145_abnormal_muscle_electrophysio0.80555822
64MP0005645_abnormal_hypothalamus_physiol0.79551427
65MP0002722_abnormal_immune_system0.79546459
66MP0002398_abnormal_bone_marrow0.78590854
67MP0003950_abnormal_plasma_membrane0.78378001
68MP0010307_abnormal_tumor_latency0.77690233
69MP0005646_abnormal_pituitary_gland0.76640712
70MP0002084_abnormal_developmental_patter0.74727539
71MP0000689_abnormal_spleen_morphology0.74365550
72MP0003121_genomic_imprinting0.73974288
73MP0008872_abnormal_physiological_respon0.73411292
74MP0003878_abnormal_ear_physiology0.73380561
75MP0005377_hearing/vestibular/ear_phenot0.73380561
76MP0001986_abnormal_taste_sensitivity0.73304656
77MP0000015_abnormal_ear_pigmentation0.73139925
78MP0005085_abnormal_gallbladder_physiolo0.72707202
79MP0003787_abnormal_imprinting0.72705377
80MP0005075_abnormal_melanosome_morpholog0.72321584
81MP0000313_abnormal_cell_death0.72318767
82MP0001919_abnormal_reproductive_system0.71895125
83MP0005266_abnormal_metabolism0.68728682
84MP0005332_abnormal_amino_acid0.67602089
85MP0003984_embryonic_growth_retardation0.67322139
86MP0000358_abnormal_cell_content/0.66848874
87MP0002080_prenatal_lethality0.65755701
88MP0003252_abnormal_bile_duct0.64510879
89MP0008875_abnormal_xenobiotic_pharmacok0.63750178
90MP0008260_abnormal_autophagy0.63730181
91MP0002088_abnormal_embryonic_growth/wei0.63009106
92MP0002429_abnormal_blood_cell0.61029914
93MP0008961_abnormal_basal_metabolism0.60604291
94MP0002269_muscular_atrophy0.59269975
95MP0003959_abnormal_lean_body0.58776297
96MP0002970_abnormal_white_adipose0.57419649
97MP0002019_abnormal_tumor_incidence0.56805354
98MP0000631_abnormal_neuroendocrine_gland0.56724152
99MP0000647_abnormal_sebaceous_gland0.55915881
100MP0009115_abnormal_fat_cell0.54723267
101MP0000609_abnormal_liver_physiology0.54369766
102MP0005319_abnormal_enzyme/_coenzyme0.54004990
103MP0001765_abnormal_ion_homeostasis0.52522014
104MP0002295_abnormal_pulmonary_circulatio0.49020468
105MP0001293_anophthalmia0.48159068
106MP0002234_abnormal_pharynx_morphology0.47389772
107MP0006036_abnormal_mitochondrial_physio0.46388071
108MP0001545_abnormal_hematopoietic_system0.45838285
109MP0005397_hematopoietic_system_phenotyp0.45838285
110MP0004808_abnormal_hematopoietic_stem0.45456480
111MP0004036_abnormal_muscle_relaxation0.45451653
112MP0003937_abnormal_limbs/digits/tail_de0.44290062
113MP0006072_abnormal_retinal_apoptosis0.43073301
114MP0003861_abnormal_nervous_system0.42258328
115MP0003115_abnormal_respiratory_system0.41828300
116MP0003936_abnormal_reproductive_system0.39738800
117MP0002086_abnormal_extraembryonic_tissu0.38934332
118MP0000579_abnormal_nail_morphology0.37624121
119MP0004264_abnormal_extraembryonic_tissu0.35375037
120MP0005384_cellular_phenotype0.35133482
121MP0001984_abnormal_olfaction0.34719561
122MP0003011_delayed_dark_adaptation0.33977445
123MP0001915_intracranial_hemorrhage0.33788568
124MP0009672_abnormal_birth_weight0.31210502
125MP0006292_abnormal_olfactory_placode0.30412277
126MP0001529_abnormal_vocalization0.30107824
127MP0004197_abnormal_fetal_growth/weight/0.30021975
128MP0001727_abnormal_embryo_implantation0.29400586
129MP0005666_abnormal_adipose_tissue0.28459360
130MP0005621_abnormal_cell_physiology0.28378821
131MP0005391_vision/eye_phenotype0.26454053
132MP0000432_abnormal_head_morphology0.26395952
133MP0003890_abnormal_embryonic-extraembry0.26201786
134MP0003329_amyloid_beta_deposits0.26071896
135MP0009697_abnormal_copulation0.25816971
136MP0001661_extended_life_span0.25396021
137MP0004084_abnormal_cardiac_muscle0.25120861
138MP0005636_abnormal_mineral_homeostasis0.24148405
139MP0000534_abnormal_ureter_morphology0.22836024
140MP0002092_abnormal_eye_morphology0.21882331
141MP0006035_abnormal_mitochondrial_morpho0.21780469
142MP0000001_mammalian_phenotype0.21752201
143MP0001764_abnormal_homeostasis0.21564517
144MP0001905_abnormal_dopamine_level0.20931982

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.26744032
2Abnormal respiratory motile cilium morphology (HP:0005938)7.53470961
3Abnormal respiratory epithelium morphology (HP:0012253)7.53470961
4Infertility (HP:0000789)7.10372509
5Rhinitis (HP:0012384)6.93392181
6Chronic bronchitis (HP:0004469)6.80700354
7Abnormal ciliary motility (HP:0012262)6.31127611
8Male infertility (HP:0003251)5.57398865
9Nasal polyposis (HP:0100582)5.25244629
10Abnormal spermatogenesis (HP:0008669)5.14936494
11Bronchiectasis (HP:0002110)4.35773188
12Azoospermia (HP:0000027)4.30139373
13Abnormality of the nasal mucosa (HP:0000433)4.17643465
14Bronchitis (HP:0012387)4.03149901
15Nephronophthisis (HP:0000090)3.99609411
16Impulsivity (HP:0100710)3.87008944
17Truncus arteriosus (HP:0001660)3.41721874
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.39546592
19Abnormality of the renal medulla (HP:0100957)2.99506826
20Acute encephalopathy (HP:0006846)2.97091727
21Acute necrotizing encephalopathy (HP:0006965)2.96719012
22Increased CSF lactate (HP:0002490)2.94721341
23Hyperthyroidism (HP:0000836)2.92957484
24Recurrent otitis media (HP:0000403)2.90995678
25Gonadotropin excess (HP:0000837)2.88848720
26Abnormality of midbrain morphology (HP:0002418)2.79099255
27Molar tooth sign on MRI (HP:0002419)2.79099255
28Abnormality of glycolysis (HP:0004366)2.75882741
29Abnormal mitochondria in muscle tissue (HP:0008316)2.75467651
30Myelodysplasia (HP:0002863)2.75345145
31Increased serum pyruvate (HP:0003542)2.73558382
32Increased serum lactate (HP:0002151)2.66917874
33Increased hepatocellular lipid droplets (HP:0006565)2.63755113
34Abnormal hemoglobin (HP:0011902)2.58460273
35Mitochondrial inheritance (HP:0001427)2.58398103
36Recurrent sinusitis (HP:0011108)2.54370575
37Aplastic anemia (HP:0001915)2.53466881
38Pallor (HP:0000980)2.52638369
39Microvesicular hepatic steatosis (HP:0001414)2.52535689
40Acute myeloid leukemia (HP:0004808)2.51540969
41Progressive macrocephaly (HP:0004481)2.50208008
42Lipid accumulation in hepatocytes (HP:0006561)2.50101857
43Reticulocytopenia (HP:0001896)2.47008657
44Premature ovarian failure (HP:0008209)2.44337307
45Hypertensive crisis (HP:0100735)2.39947105
46Abnormality of the lower motor neuron (HP:0002366)2.38680834
47Duplicated collecting system (HP:0000081)2.37360396
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37145583
49Tubulointerstitial nephritis (HP:0001970)2.36782403
50Abnormality of homocysteine metabolism (HP:0010919)2.36618683
51Homocystinuria (HP:0002156)2.36618683
52Supernumerary spleens (HP:0009799)2.36269890
53Aplasia/Hypoplasia of the earlobes (HP:0009906)2.35624006
54Abnormality of reticulocytes (HP:0004312)2.35159401
55Ileus (HP:0002595)2.32177517
56Hepatic necrosis (HP:0002605)2.31745392
57Renal Fanconi syndrome (HP:0001994)2.31099703
58Lactic acidosis (HP:0003128)2.30332603
59Reticulocytosis (HP:0001923)2.29546595
60Seborrheic dermatitis (HP:0001051)2.29324278
61Tinnitus (HP:0000360)2.28819244
62Hepatocellular necrosis (HP:0001404)2.26930738
63Abnormality of the renal collecting system (HP:0004742)2.26901985
64Abnormality of the pons (HP:0007361)2.26837531
65Abnormality of cells of the erythroid lineage (HP:0012130)2.26659623
66Tubular atrophy (HP:0000092)2.25320142
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.22733518
68Hypoplasia of the pons (HP:0012110)2.20384637
69Medial flaring of the eyebrow (HP:0010747)2.19531242
70Recurrent bronchitis (HP:0002837)2.18116265
71Abnormality of the labia minora (HP:0012880)2.17077590
72Abnormality of DNA repair (HP:0003254)2.16907603
73Abnormality of the duodenum (HP:0002246)2.13601559
74Cerebral hypomyelination (HP:0006808)2.12808069
75Abnormality of cochlea (HP:0000375)2.12116201
76Carpal bone hypoplasia (HP:0001498)2.10467505
77Chromsome breakage (HP:0040012)2.07899882
78Abnormal number of erythroid precursors (HP:0012131)2.07611574
79Tubulointerstitial abnormality (HP:0001969)2.06731305
80Amyotrophic lateral sclerosis (HP:0007354)2.04749148
81Cerebral edema (HP:0002181)2.03116482
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02958261
83Abnormality of alanine metabolism (HP:0010916)2.02958261
84Hyperalaninemia (HP:0003348)2.02958261
853-Methylglutaconic aciduria (HP:0003535)2.02021412
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00732891
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3065951
88Dynein arm defect of respiratory motile cilia (HP:0012255)10.7923295
89Absent/shortened dynein arms (HP:0200106)10.7923295
90Clubbing of toes (HP:0100760)1.98589165
91Aplasia/Hypoplasia of the thymus (HP:0010515)1.96814912
92Absent thumb (HP:0009777)1.96228690
93Poikilocytosis (HP:0004447)1.93865896
94Hypoparathyroidism (HP:0000829)1.92536675
95Cholelithiasis (HP:0001081)1.91925182
96Postaxial foot polydactyly (HP:0001830)1.91669853
97Pancreatic fibrosis (HP:0100732)1.91441743
98Abnormality of methionine metabolism (HP:0010901)1.90379114
99Macrocytic anemia (HP:0001972)1.90303634
100Type I transferrin isoform profile (HP:0003642)1.90095256
101Sloping forehead (HP:0000340)1.88253764
102Respiratory difficulties (HP:0002880)1.87538897
103Horseshoe kidney (HP:0000085)1.86156719
104Breast hypoplasia (HP:0003187)1.84865502
105Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84785760
106Degeneration of anterior horn cells (HP:0002398)1.84372947
107Abnormality of the anterior horn cell (HP:0006802)1.84372947
108Papillary thyroid carcinoma (HP:0002895)1.83543623
109Facial cleft (HP:0002006)1.83358654
110Generalized aminoaciduria (HP:0002909)1.82429344
111Upper limb muscle weakness (HP:0003484)1.82257525
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81036778
113Absent epiphyses (HP:0010577)1.81036778
114Heterotopia (HP:0002282)1.80613898
115Abnormality of the carotid arteries (HP:0005344)1.80341757
116Abnormality of lateral ventricle (HP:0030047)1.79162102
117Short ribs (HP:0000773)1.79061547
118Entropion (HP:0000621)1.78261691
119Pancytopenia (HP:0001876)1.77174708
120Volvulus (HP:0002580)1.76867104
121Hypergonadotropic hypogonadism (HP:0000815)1.76795175
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.76494947
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75690000
124CNS hypomyelination (HP:0003429)1.75206817
125Abnormal large intestine physiology (HP:0012700)1.75133690
126Meckel diverticulum (HP:0002245)1.74961228
127Bowel incontinence (HP:0002607)1.74508019
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74475285
129Increased intramyocellular lipid droplets (HP:0012240)1.74232394
130Cholecystitis (HP:0001082)1.73349777
131Abnormal gallbladder physiology (HP:0012438)1.73349777
132Fibular hypoplasia (HP:0003038)1.72737093
133Abnormality of chromosome stability (HP:0003220)1.72541590
134Limb hypertonia (HP:0002509)1.72436205
135Spastic tetraparesis (HP:0001285)1.72320271
136Microglossia (HP:0000171)1.70226405
137Abnormal gallbladder morphology (HP:0012437)1.69867635
138Abnormality of T cell physiology (HP:0011840)1.67233278
139Palpitations (HP:0001962)1.67029766
140Tubulointerstitial fibrosis (HP:0005576)1.65862336
141Abnormality of the ileum (HP:0001549)1.65640481
142Secondary amenorrhea (HP:0000869)1.65022102
143Nausea (HP:0002018)1.64522860
144Oculomotor apraxia (HP:0000657)1.64522200
145Abnormality of the preputium (HP:0100587)1.63376871
146Ectopic kidney (HP:0000086)1.62653462
147Birth length less than 3rd percentile (HP:0003561)1.62360042
148Duodenal stenosis (HP:0100867)1.60847110
149Small intestinal stenosis (HP:0012848)1.60847110
150Nephroblastoma (Wilms tumor) (HP:0002667)1.57365938
151Congenital hepatic fibrosis (HP:0002612)1.56468540
152Stage 5 chronic kidney disease (HP:0003774)1.54850764
153Median cleft lip (HP:0000161)1.52588178
154Renal dysplasia (HP:0000110)1.49473568
155Upper motor neuron abnormality (HP:0002127)1.48831347
156Pancreatic cysts (HP:0001737)1.47161577
157Personality changes (HP:0000751)1.46579354
158Type 2 muscle fiber atrophy (HP:0003554)1.45849286
159Cystic liver disease (HP:0006706)1.44920417
160Aplasia/Hypoplasia of the fibula (HP:0006492)1.44103984
161Embryonal renal neoplasm (HP:0011794)1.43714742
162Abnormality of the renal cortex (HP:0011035)1.42943850
163Postaxial hand polydactyly (HP:0001162)1.42616181
164Abnormal biliary tract physiology (HP:0012439)1.42348167
165Bile duct proliferation (HP:0001408)1.42348167
166Aplasia/Hypoplasia of the tongue (HP:0010295)1.40791583
167Facial hemangioma (HP:0000329)1.40136733
168Abnormality of the dental root (HP:0006486)1.39439810
169Taurodontia (HP:0000679)1.39439810
170Abnormality of permanent molar morphology (HP:0011071)1.39439810
171Poor coordination (HP:0002370)1.38411570
172Selective tooth agenesis (HP:0001592)1.33643036
173Abnormal lung lobation (HP:0002101)1.33612607
174Breast carcinoma (HP:0003002)1.31797202
175Abnormal drinking behavior (HP:0030082)1.31433020
176Polydipsia (HP:0001959)1.31433020
177Impaired proprioception (HP:0010831)1.29914891
178Aplasia/hypoplasia of the humerus (HP:0006507)1.29128065
179Congenital primary aphakia (HP:0007707)1.28926161
180Cleft eyelid (HP:0000625)1.28288788
181Patellar aplasia (HP:0006443)1.27828057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.31838469
2PDK47.31838469
3PDK24.67832375
4MST44.47082330
5TESK14.38134579
6PRKD34.10653404
7PBK2.93129302
8ICK2.88926555
9TTK2.71037775
10NEK22.66912000
11PLK42.43633130
12ZAK2.24837417
13CDC72.20612817
14NME12.12486200
15PNCK2.03363584
16WEE12.01871763
17NUAK11.95300813
18NME21.88281886
19BUB11.79710630
20CLK11.77245343
21STK38L1.71175083
22RIPK41.63001032
23RAF11.61752148
24PTK2B1.54062520
25STK381.53076854
26ACVR1B1.50717372
27CHEK21.49873606
28TSSK61.48279504
29WNK41.43656311
30BRAF1.41023054
31PLK11.40918869
32MAP3K131.34666187
33MAP3K61.34474310
34STK31.33601368
35STK391.32951757
36BRSK21.18525016
37DYRK31.16761155
38EEF2K1.14950240
39TNIK1.11105297
40EIF2AK21.07019167
41PINK11.06520339
42MKNK11.04411240
43STK161.01698253
44RPS6KB21.00644476
45EIF2AK11.00169070
46CCNB10.94767077
47NTRK30.93908969
48CHEK10.93138591
49SCYL20.92968718
50MAP4K20.91117559
51TYRO30.90529127
52MKNK20.89699435
53MUSK0.89668967
54VRK20.89094293
55STK100.89020838
56ATR0.81141013
57TRIM280.79891849
58LATS20.78936357
59INSRR0.77799187
60MOS0.76769946
61DYRK1B0.76619292
62CDK120.75932112
63TLK10.75282304
64TEC0.73576889
65BRSK10.72705598
66LATS10.71264143
67ATM0.68752984
68AURKA0.68630385
69PDK10.68171746
70MELK0.67219553
71LRRK20.67154037
72AURKB0.66405961
73PRKCI0.65682875
74BMPR20.64940867
75TRPM70.63777419
76PASK0.63119418
77ERBB40.62686318
78PIK3CG0.61664599
79SRPK10.61549372
80TESK20.61075872
81KSR10.61065712
82MARK30.56740886
83TAOK30.55556580
84ALK0.52324148
85PLK30.51845709
86PAK10.50900632
87MAPKAPK30.50361266
88MAP3K20.49904991
89MAP3K80.48808621
90NEK10.46344730
91RPS6KA50.44971863
92TAOK10.43551914
93MAP3K40.39258848
94CDK20.38863878
95ILK0.38750748
96PRKAA10.38479500
97CDK40.38008738
98IRAK10.37057735
99CDK10.36943139
100MAP3K90.35405178
101CDK70.34064594
102MTOR0.32903791
103WNK10.32614315
104PLK20.32545224
105MAPKAPK50.31859859
106PRKCQ0.29717016
107TXK0.29128202
108BRD40.28867442
109PDPK10.27658686
110EPHA20.27613689
111BMPR1B0.27045975
112ARAF0.26706343
113KSR20.25502528
114OXSR10.24829610
115BMX0.24717945
116DYRK20.24369536
117FRK0.23688274
118MATK0.23573756
119AKT20.22947201
120STK240.22755870
121CSNK2A10.22406420
122MAP3K140.21954086
123ERBB30.21780935
124CDK80.20294618
125CDK30.19437062
126MAPK150.17516284
127AKT30.17228680
128GSK3B0.14414932
129CSNK1D0.14210128
130MAP2K70.13454146
131MAP3K50.13110088
132CDK90.13064104
133PIM10.12581968
134STK40.12469428
135CSNK2A20.12142323
136RPS6KA40.12094071
137NTRK20.10702343
138NEK60.10339238
139VRK10.10270980
140EIF2AK30.09735696
141LMTK20.09211524
142CSNK1E0.07938807
143IRAK20.07366649
144RPS6KA10.07241485
145PRKDC0.06954561
146PAK60.06633954

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.54071993
2Vitamin B6 metabolism_Homo sapiens_hsa007504.48291972
3Fanconi anemia pathway_Homo sapiens_hsa034603.29898010
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11625743
5RNA transport_Homo sapiens_hsa030133.06499585
6Ribosome_Homo sapiens_hsa030102.77166887
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.71566817
8Cell cycle_Homo sapiens_hsa041102.63690052
9Homologous recombination_Homo sapiens_hsa034402.63512125
10Oocyte meiosis_Homo sapiens_hsa041142.62205995
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.61963193
12Linoleic acid metabolism_Homo sapiens_hsa005912.61844673
13DNA replication_Homo sapiens_hsa030302.47022260
14Fatty acid biosynthesis_Homo sapiens_hsa000612.25331481
15Pyruvate metabolism_Homo sapiens_hsa006202.25042885
16mRNA surveillance pathway_Homo sapiens_hsa030152.24718873
17RNA degradation_Homo sapiens_hsa030182.15582621
18Proteasome_Homo sapiens_hsa030502.11663906
19Mismatch repair_Homo sapiens_hsa034302.04643422
20Oxidative phosphorylation_Homo sapiens_hsa001902.03504684
21Selenocompound metabolism_Homo sapiens_hsa004501.99524541
22Parkinsons disease_Homo sapiens_hsa050121.98648401
23RNA polymerase_Homo sapiens_hsa030201.84173980
24Base excision repair_Homo sapiens_hsa034101.83663331
25Dorso-ventral axis formation_Homo sapiens_hsa043201.82762136
26Pentose phosphate pathway_Homo sapiens_hsa000301.77224126
27Nucleotide excision repair_Homo sapiens_hsa034201.75304556
28Pyrimidine metabolism_Homo sapiens_hsa002401.73903258
29Purine metabolism_Homo sapiens_hsa002301.70528580
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.67165203
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.64118141
32Protein export_Homo sapiens_hsa030601.63760537
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61527798
34Non-homologous end-joining_Homo sapiens_hsa034501.52527844
35Spliceosome_Homo sapiens_hsa030401.47148701
36Glucagon signaling pathway_Homo sapiens_hsa049221.46152154
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45978303
38Propanoate metabolism_Homo sapiens_hsa006401.43121548
39Olfactory transduction_Homo sapiens_hsa047401.39760187
40Ether lipid metabolism_Homo sapiens_hsa005651.39566515
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35689513
42Glycerolipid metabolism_Homo sapiens_hsa005611.35421922
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34392364
44Huntingtons disease_Homo sapiens_hsa050161.16596169
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13807457
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04633530
47p53 signaling pathway_Homo sapiens_hsa041151.02568734
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99385053
49Alzheimers disease_Homo sapiens_hsa050100.97614759
50Fructose and mannose metabolism_Homo sapiens_hsa000510.96692251
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91808202
52Biosynthesis of amino acids_Homo sapiens_hsa012300.90031916
53Butanoate metabolism_Homo sapiens_hsa006500.89390076
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89297263
55Folate biosynthesis_Homo sapiens_hsa007900.86743547
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85910814
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82244971
58Ovarian steroidogenesis_Homo sapiens_hsa049130.82066178
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80675893
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80308718
61Epstein-Barr virus infection_Homo sapiens_hsa051690.79167722
62Arachidonic acid metabolism_Homo sapiens_hsa005900.78984900
63Carbon metabolism_Homo sapiens_hsa012000.78396851
64Glutathione metabolism_Homo sapiens_hsa004800.74681274
65Mineral absorption_Homo sapiens_hsa049780.73651520
66Fatty acid elongation_Homo sapiens_hsa000620.72878147
67Steroid biosynthesis_Homo sapiens_hsa001000.71666531
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.70602057
69Antigen processing and presentation_Homo sapiens_hsa046120.69213211
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68274666
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63945192
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63331718
73Hedgehog signaling pathway_Homo sapiens_hsa043400.61511849
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61155027
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58854733
76Fat digestion and absorption_Homo sapiens_hsa049750.58026995
77PPAR signaling pathway_Homo sapiens_hsa033200.55540972
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50551328
79Circadian rhythm_Homo sapiens_hsa047100.48193287
80Regulation of autophagy_Homo sapiens_hsa041400.46714645
81Caffeine metabolism_Homo sapiens_hsa002320.42827549
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41438992
83Inositol phosphate metabolism_Homo sapiens_hsa005620.39497059
84Viral carcinogenesis_Homo sapiens_hsa052030.39226256
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.38007530
86Metabolic pathways_Homo sapiens_hsa011000.37865488
87Sulfur metabolism_Homo sapiens_hsa009200.37642673
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37427934
89Amphetamine addiction_Homo sapiens_hsa050310.36799918
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35819858
91Fatty acid metabolism_Homo sapiens_hsa012120.35158962
92N-Glycan biosynthesis_Homo sapiens_hsa005100.33374612
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33044069
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32442807
95Cardiac muscle contraction_Homo sapiens_hsa042600.31296007
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30686903
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.30460068
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29934522
99Renin-angiotensin system_Homo sapiens_hsa046140.29443104
100One carbon pool by folate_Homo sapiens_hsa006700.29432947
101Herpes simplex infection_Homo sapiens_hsa051680.29408842
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29343491
103HTLV-I infection_Homo sapiens_hsa051660.29201615
104Systemic lupus erythematosus_Homo sapiens_hsa053220.28763865
105AMPK signaling pathway_Homo sapiens_hsa041520.28469861
106Peroxisome_Homo sapiens_hsa041460.28196055
107Estrogen signaling pathway_Homo sapiens_hsa049150.28051878
108Arginine biosynthesis_Homo sapiens_hsa002200.27270481
109Primary immunodeficiency_Homo sapiens_hsa053400.26748583
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26356623
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26090330
112Acute myeloid leukemia_Homo sapiens_hsa052210.23308764
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23186415
114VEGF signaling pathway_Homo sapiens_hsa043700.22188944
115Phototransduction_Homo sapiens_hsa047440.22085437
116Fatty acid degradation_Homo sapiens_hsa000710.20904833
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20252904
118Endocytosis_Homo sapiens_hsa041440.19604916
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19367375
120Sphingolipid metabolism_Homo sapiens_hsa006000.17541523
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.16287831
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16134351
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.15729520
124Thyroid cancer_Homo sapiens_hsa052160.15137646
125TGF-beta signaling pathway_Homo sapiens_hsa043500.14180725
126Nitrogen metabolism_Homo sapiens_hsa009100.13547722
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13176531
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12788420
129Sulfur relay system_Homo sapiens_hsa041220.12542981
130Measles_Homo sapiens_hsa051620.12445361
131Chemical carcinogenesis_Homo sapiens_hsa052040.11819150
132Other glycan degradation_Homo sapiens_hsa005110.11537806
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10613187
134mTOR signaling pathway_Homo sapiens_hsa041500.10534372
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10081064
136HIF-1 signaling pathway_Homo sapiens_hsa040660.09938361
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09400661
138Hippo signaling pathway_Homo sapiens_hsa043900.08822514
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.08552134
140Influenza A_Homo sapiens_hsa051640.08373169
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.07897021
142Collecting duct acid secretion_Homo sapiens_hsa049660.07176224
143Arginine and proline metabolism_Homo sapiens_hsa003300.06893717
144Legionellosis_Homo sapiens_hsa051340.06884772
145Hepatitis B_Homo sapiens_hsa051610.01666190
146Shigellosis_Homo sapiens_hsa051310.01071299

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