GTSF1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.31770468
2cell wall macromolecule metabolic process (GO:0044036)9.31770468
3fusion of sperm to egg plasma membrane (GO:0007342)9.03915771
4response to pheromone (GO:0019236)8.26004011
5sperm motility (GO:0030317)8.01908614
6sperm-egg recognition (GO:0035036)7.82502042
7protein targeting to Golgi (GO:0000042)7.67503735
8rRNA methylation (GO:0031167)7.58433765
9protein polyglutamylation (GO:0018095)7.48326179
10establishment of protein localization to Golgi (GO:0072600)7.35858291
11binding of sperm to zona pellucida (GO:0007339)7.20113424
12acrosome assembly (GO:0001675)7.16841258
13multicellular organism reproduction (GO:0032504)7.15504159
14retrograde transport, vesicle recycling within Golgi (GO:0000301)7.15248468
15cell-cell recognition (GO:0009988)6.98040158
16axonemal dynein complex assembly (GO:0070286)6.84024759
17plasma membrane fusion (GO:0045026)6.73721820
18motile cilium assembly (GO:0044458)6.65328345
19sexual reproduction (GO:0019953)6.64311810
20acrosome reaction (GO:0007340)6.49951872
21spermatid development (GO:0007286)6.47516365
22rRNA modification (GO:0000154)6.40500385
23cilium or flagellum-dependent cell motility (GO:0001539)6.38129251
24epithelial cilium movement (GO:0003351)6.31727368
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.30642622
26centriole replication (GO:0007099)6.16752781
27reproduction (GO:0000003)6.01763563
28regulation of cilium movement (GO:0003352)5.87512797
29phosphatidylethanolamine metabolic process (GO:0046337)5.81963002
30protein localization to Golgi apparatus (GO:0034067)5.57195497
31synaptonemal complex assembly (GO:0007130)5.52585925
32centriole assembly (GO:0098534)5.41283402
33synaptonemal complex organization (GO:0070193)5.38892063
34piRNA metabolic process (GO:0034587)5.36869203
35cilium movement (GO:0003341)5.27961334
36microtubule depolymerization (GO:0007019)5.19763188
37male meiosis (GO:0007140)5.07303063
38regulation of Rab GTPase activity (GO:0032313)5.06222075
39positive regulation of Rab GTPase activity (GO:0032851)5.06222075
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.95240348
41RNA destabilization (GO:0050779)4.93902269
42cellular ketone body metabolic process (GO:0046950)4.93675760
43glomerular visceral epithelial cell development (GO:0072015)4.74834294
44single fertilization (GO:0007338)4.68896772
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58487658
46chromatin silencing (GO:0006342)4.51810073
47glomerular epithelial cell development (GO:0072310)4.46806947
48chaperone-mediated protein complex assembly (GO:0051131)4.40216885
49spermatogenesis (GO:0007283)4.36437524
50male gamete generation (GO:0048232)4.35763700
51ketone body metabolic process (GO:1902224)4.34881788
52regulation of transcription involved in cell fate commitment (GO:0060850)4.21495941
53single strand break repair (GO:0000012)4.20759616
54fertilization (GO:0009566)4.15220264
55chromosome organization involved in meiosis (GO:0070192)4.11601485
56multicellular organismal movement (GO:0050879)4.02478877
57musculoskeletal movement (GO:0050881)4.02478877
58gamete generation (GO:0007276)4.02089801
59chromosome condensation (GO:0030261)4.00882896
60meiotic nuclear division (GO:0007126)3.91794483
61DNA packaging (GO:0006323)3.88167916
62microtubule nucleation (GO:0007020)3.86751757
63germ cell development (GO:0007281)3.82192811
64DNA deamination (GO:0045006)3.78856682
65sperm capacitation (GO:0048240)3.77655789
66DNA methylation involved in gamete generation (GO:0043046)3.75626684
67DNA replication-dependent nucleosome organization (GO:0034723)3.73402972
68DNA replication-dependent nucleosome assembly (GO:0006335)3.73402972
69male meiosis I (GO:0007141)3.72003719
70negative regulation of inclusion body assembly (GO:0090084)3.69154130
71regulation of inclusion body assembly (GO:0090083)3.67924373
72protein localization to chromosome, centromeric region (GO:0071459)3.64309190
73negative regulation of Rho protein signal transduction (GO:0035024)3.63966801
74ether metabolic process (GO:0018904)3.61903243
75regulation of spindle checkpoint (GO:0090231)3.59577792
76cellular process involved in reproduction in multicellular organism (GO:0022412)3.58955377
77coenzyme catabolic process (GO:0009109)3.51753258
78regulation of microtubule-based movement (GO:0060632)3.46854249
79organic cation transport (GO:0015695)3.43896277
80nuclear pore organization (GO:0006999)3.40376048
81meiosis I (GO:0007127)3.39576721
82nuclear pore complex assembly (GO:0051292)3.39116202
83response to acidic pH (GO:0010447)3.38792258
84microtubule severing (GO:0051013)3.36626585
85spermatid nucleus differentiation (GO:0007289)3.34633758
86cellular response to pH (GO:0071467)3.32672309
87ventricular system development (GO:0021591)3.30862117
88histone exchange (GO:0043486)3.29859940
89regulation of centriole replication (GO:0046599)3.27717593
90interferon-gamma secretion (GO:0072643)3.27619267
91membrane protein intracellular domain proteolysis (GO:0031293)3.26446603
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19850093
93regulation of interleukin-13 production (GO:0032656)3.18279862
94polyamine biosynthetic process (GO:0006596)3.18079677
95histone H3-K9 demethylation (GO:0033169)3.17721201
96protein depolymerization (GO:0051261)3.17564653
97UTP biosynthetic process (GO:0006228)3.17196966
98GTP biosynthetic process (GO:0006183)3.16568847
99DNA replication initiation (GO:0006270)3.15831627
100protein-DNA complex disassembly (GO:0032986)3.15175316
101nucleosome disassembly (GO:0006337)3.15175316
102meiotic cell cycle process (GO:1903046)3.14184981
103mitotic metaphase plate congression (GO:0007080)3.11870817
104cerebral cortex neuron differentiation (GO:0021895)3.11814980
105multicellular organismal reproductive process (GO:0048609)3.11477918
106homeostasis of number of cells within a tissue (GO:0048873)3.08022962
107mitotic nuclear envelope disassembly (GO:0007077)3.06309205
108nucleus organization (GO:0006997)3.05532680
109negative regulation of gene expression, epigenetic (GO:0045814)3.05110065
110multicellular organismal development (GO:0007275)3.02767622
111regulation of somitogenesis (GO:0014807)3.02281910
112ribosome biogenesis (GO:0042254)3.01192749
113cell recognition (GO:0008037)3.01180672
114formation of translation preinitiation complex (GO:0001731)3.00805299
115DNA conformation change (GO:0071103)3.00185403
116regulation of T-helper 2 cell differentiation (GO:0045628)3.00073730
117intra-Golgi vesicle-mediated transport (GO:0006891)2.99760650
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99746749
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.99746749
120protein complex localization (GO:0031503)2.96358745
121nucleoside diphosphate phosphorylation (GO:0006165)2.94171558
122protein K6-linked ubiquitination (GO:0085020)2.88972390
123microtubule polymerization or depolymerization (GO:0031109)2.87526447
124regulation of centrosome cycle (GO:0046605)2.87316458
125glycerol ether metabolic process (GO:0006662)2.87279796
126receptor recycling (GO:0001881)2.85724165
127purine nucleobase biosynthetic process (GO:0009113)2.84109938
128nuclear envelope disassembly (GO:0051081)2.83818648
129membrane disassembly (GO:0030397)2.83818648
130nucleobase biosynthetic process (GO:0046112)2.83656881
131mitotic sister chromatid segregation (GO:0000070)2.82278272
132meiotic cell cycle (GO:0051321)2.82094514
133ribosome assembly (GO:0042255)2.81271032
134regulation of chromosome segregation (GO:0051983)2.80312617
135mitotic G1 DNA damage checkpoint (GO:0031571)2.80031198
136peptidyl-threonine dephosphorylation (GO:0035970)2.79507405
137regulation of posttranscriptional gene silencing (GO:0060147)2.76758008
138regulation of gene silencing by miRNA (GO:0060964)2.76758008
139regulation of gene silencing by RNA (GO:0060966)2.76758008
140seminiferous tubule development (GO:0072520)2.74899269
141regulation of phosphoprotein phosphatase activity (GO:0043666)2.74583716
142guanosine-containing compound biosynthetic process (GO:1901070)2.72995679
143protein localization to kinetochore (GO:0034501)2.71682233
144pore complex assembly (GO:0046931)2.71625798
145mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71342681
146mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71342681
147vesicle transport along microtubule (GO:0047496)2.70792557
148cranial nerve morphogenesis (GO:0021602)2.70736746
149UTP metabolic process (GO:0046051)2.70640794
150DNA replication checkpoint (GO:0000076)2.70638526
151regulation of histone H3-K9 methylation (GO:0051570)2.68263309
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67999396
153pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67334488
154DNA strand elongation involved in DNA replication (GO:0006271)2.67067245
155calcium ion-dependent exocytosis (GO:0017156)2.66035990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.56747800
2E2F7_22180533_ChIP-Seq_HELA_Human4.92421277
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.90274103
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.70830265
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.10431331
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.06044982
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.88176896
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68341830
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.50621723
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50621723
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42873969
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39688857
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38693942
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37857005
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.36293488
16CBP_20019798_ChIP-Seq_JUKART_Human2.36293488
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32154250
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29015919
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26581254
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18830915
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13956742
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.12005430
23FUS_26573619_Chip-Seq_HEK293_Human2.07999483
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01387422
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.98992425
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98197882
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97819694
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97819694
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97819694
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.96781790
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96438857
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.96353865
33ERA_21632823_ChIP-Seq_H3396_Human1.96083015
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95098266
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94941439
36* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94673907
37DROSHA_22980978_ChIP-Seq_HELA_Human1.92462949
38EZH2_22144423_ChIP-Seq_EOC_Human1.92387175
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87602880
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86535644
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84386579
42* RAC3_21632823_ChIP-Seq_H3396_Human1.83812266
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83166200
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.82324612
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.80479812
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77887505
47NANOG_20526341_ChIP-Seq_ESCs_Human1.76291996
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75005131
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.73509281
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72654070
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72479157
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.71255538
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.70722011
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68423324
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.68149045
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68129672
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67676846
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66555509
59TAF2_19829295_ChIP-Seq_ESCs_Human1.64297253
60CTCF_27219007_Chip-Seq_Bcells_Human1.64003109
61MYC_19829295_ChIP-Seq_ESCs_Human1.63501285
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.60659042
63ER_23166858_ChIP-Seq_MCF-7_Human1.60615738
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.59356925
65BCL6_27268052_Chip-Seq_Bcells_Human1.57407624
66SMC4_20622854_ChIP-Seq_HELA_Human1.54634762
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.54609864
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51874732
69XRN2_22483619_ChIP-Seq_HELA_Human1.49764502
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.49422913
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49312352
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48811158
73BCOR_27268052_Chip-Seq_Bcells_Human1.48648300
74E2F1_20622854_ChIP-Seq_HELA_Human1.47832300
75CTCF_20526341_ChIP-Seq_ESCs_Human1.46467723
76* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46395899
77* SMAD4_21741376_ChIP-Seq_EPCs_Human1.46145861
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45171147
79P68_20966046_ChIP-Seq_HELA_Human1.44261423
80OCT4_20526341_ChIP-Seq_ESCs_Human1.43901315
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43139978
82TP53_18474530_ChIP-ChIP_U2OS_Human1.43071000
83CBX2_22325352_ChIP-Seq_293T-Rex_Human1.43011103
84AR_25329375_ChIP-Seq_VCAP_Human1.42697196
85TP63_22573176_ChIP-Seq_HFKS_Human1.42546339
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.41539540
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40369668
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.40339348
89RBPJ_21746931_ChIP-Seq_IB4_Human1.39702673
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37507653
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.36607653
92ERG_20517297_ChIP-Seq_VCAP_Human1.36425316
93VDR_23849224_ChIP-Seq_CD4+_Human1.35121971
94* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34336821
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33867600
96CEBPB_22108803_ChIP-Seq_LS180_Human1.33803070
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.33088587
98ETV1_20927104_ChIP-Seq_GIST48_Human1.31344427
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.30987213
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30651430
101P300_27268052_Chip-Seq_Bcells_Human1.29242145
102HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28160325
103AR_21909140_ChIP-Seq_LNCAP_Human1.27364734
104NFYB_21822215_ChIP-Seq_K562_Human1.25720901
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.25537015
106RUNX_20019798_ChIP-Seq_JUKART_Human1.25369607
107P300_19829295_ChIP-Seq_ESCs_Human1.25051401
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24851136
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24430033
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24408762
111NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23812745
112* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23751057
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.23404865
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.23338830
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21783908
116TBL1_22424771_ChIP-Seq_293T_Human1.21108378
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21075151
118LXR_22292898_ChIP-Seq_THP-1_Human1.20537292
119ZNF274_21170338_ChIP-Seq_K562_Hela1.20508622
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19695851
121GABP_19822575_ChIP-Seq_HepG2_Human1.19313174
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19071798
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18591998
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17943367
125* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17875828
126POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17719002
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.17418482
128P53_21459846_ChIP-Seq_SAOS-2_Human1.17309927
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16771067
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15942707
131PHF8_20622853_ChIP-Seq_HELA_Human1.15367427
132SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14701469
133TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14472353
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14119798
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14111553
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14094885
137SMAD4_21741376_ChIP-Seq_HESCs_Human1.13608901
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13502055
139SMRT_27268052_Chip-Seq_Bcells_Human1.13481628
140SA1_27219007_Chip-Seq_Bcells_Human1.11498037
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10960743
142SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10703884
143TAF15_26573619_Chip-Seq_HEK293_Human1.10515299
144GATA6_21074721_ChIP-Seq_CACO-2_Human1.10451138
145NANOG_21062744_ChIP-ChIP_HESCs_Human1.10260986
146TTF2_22483619_ChIP-Seq_HELA_Human1.10056806
147NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09583468
148POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08575536
149KAP1_27257070_Chip-Seq_ESCs_Mouse1.08210713
150RUNX2_22187159_ChIP-Seq_PCA_Human1.08001475
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07997844
152FOXP3_21729870_ChIP-Seq_TREG_Human1.07968809
153SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06165952
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05368163
155RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05093381
156PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05047050
157GATA3_21867929_ChIP-Seq_CD8_Mouse1.04961301
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03628991
159NANOG_19829295_ChIP-Seq_ESCs_Human1.03153661
160SOX2_19829295_ChIP-Seq_ESCs_Human1.03153661
161E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02556725
162NFYA_21822215_ChIP-Seq_K562_Human1.02042633
163SMAD4_21799915_ChIP-Seq_A2780_Human1.01964534
164SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01954975
165HOXB7_26014856_ChIP-Seq_BT474_Human1.01920718
166GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01325065
167TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01272890
168DCP1A_22483619_ChIP-Seq_HELA_Human1.00762918
169SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00467537
170GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00386991
171SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00267317
172OCT1_27270436_Chip-Seq_PROSTATE_Human0.99373229
173* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98136141
174FLI1_27457419_Chip-Seq_LIVER_Mouse0.97992400
175HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95425145
176RARA_24833708_ChIP-Seq_LIVER_Mouse0.95330421
177TET1_21451524_ChIP-Seq_MESCs_Mouse0.94762822
178STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94191756
179KDM5A_27292631_Chip-Seq_BREAST_Human0.92165894
180ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91799586
181TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90808563
182E2F1_21310950_ChIP-Seq_MCF-7_Human0.90712226
183RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90418927
184THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88452812
185PHF8_20622854_ChIP-Seq_HELA_Human0.87957198
186VDR_22108803_ChIP-Seq_LS180_Human0.87087651
187KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86515509
188PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85827028
189NANOG_16518401_ChIP-PET_MESCs_Mouse0.85631491
190DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85462960
191PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85224582
192TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85179841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.96450808
2MP0003698_abnormal_male_reproductive4.22365531
3MP0001929_abnormal_gametogenesis4.19189159
4MP0008877_abnormal_DNA_methylation3.83652863
5MP0003693_abnormal_embryo_hatching3.72436724
6MP0001348_abnormal_lacrimal_gland3.66136913
7MP0003111_abnormal_nucleus_morphology3.54933269
8MP0002653_abnormal_ependyma_morphology3.48800229
9MP0008057_abnormal_DNA_replication3.45277457
10MP0010094_abnormal_chromosome_stability3.32100215
11MP0004957_abnormal_blastocyst_morpholog3.27910582
12MP0008058_abnormal_DNA_repair3.17011902
13MP0002210_abnormal_sex_determination3.11792504
14MP0001145_abnormal_male_reproductive2.74744631
15MP0003077_abnormal_cell_cycle2.73136108
16MP0003806_abnormal_nucleotide_metabolis2.54079080
17MP0002161_abnormal_fertility/fecundity2.47771597
18MP0000653_abnormal_sex_gland2.33278139
19MP0005670_abnormal_white_adipose2.28253083
20MP0000678_abnormal_parathyroid_gland2.28090999
21MP0004133_heterotaxia2.15059982
22MP0003011_delayed_dark_adaptation2.10634456
23MP0001730_embryonic_growth_arrest1.92723554
24MP0003718_maternal_effect1.89545252
25MP0008932_abnormal_embryonic_tissue1.86340154
26MP0005310_abnormal_salivary_gland1.79846512
27MP0005451_abnormal_body_composition1.79761049
28MP0002160_abnormal_reproductive_system1.79696489
29MP0005379_endocrine/exocrine_gland_phen1.78042762
30MP0003786_premature_aging1.78025463
31MP0001485_abnormal_pinna_reflex1.74145965
32MP0008007_abnormal_cellular_replicative1.72532144
33MP0005423_abnormal_somatic_nervous1.63858713
34MP0001486_abnormal_startle_reflex1.54372073
35MP0000350_abnormal_cell_proliferation1.47593382
36MP0001672_abnormal_embryogenesis/_devel1.45318153
37MP0005380_embryogenesis_phenotype1.45318153
38MP0004742_abnormal_vestibular_system1.44042759
39MP0010352_gastrointestinal_tract_polyps1.40699945
40MP0002234_abnormal_pharynx_morphology1.40420988
41MP0002249_abnormal_larynx_morphology1.38011426
42MP0003879_abnormal_hair_cell1.35188986
43MP0001697_abnormal_embryo_size1.33040952
44MP0002085_abnormal_embryonic_tissue1.30645493
45MP0002084_abnormal_developmental_patter1.29705998
46MP0001293_anophthalmia1.28364715
47MP0009053_abnormal_anal_canal1.26092925
48MP0004510_myositis1.25796600
49MP0005389_reproductive_system_phenotype1.25735444
50MP0004233_abnormal_muscle_weight1.22141297
51MP0003984_embryonic_growth_retardation1.19567187
52MP0010307_abnormal_tumor_latency1.18887546
53MP0003136_yellow_coat_color1.17576344
54MP0002138_abnormal_hepatobiliary_system1.17513604
55MP0002080_prenatal_lethality1.17141985
56MP0001765_abnormal_ion_homeostasis1.16737426
57MP0002088_abnormal_embryonic_growth/wei1.16215409
58MP0001963_abnormal_hearing_physiology1.14590776
59MP0003890_abnormal_embryonic-extraembry1.14257936
60MP0003941_abnormal_skin_development1.12705336
61MP0004859_abnormal_synaptic_plasticity1.12378759
62MP0003119_abnormal_digestive_system1.10287441
63MP0000534_abnormal_ureter_morphology1.09729000
64MP0002127_abnormal_cardiovascular_syste1.08321049
65MP0002086_abnormal_extraembryonic_tissu1.07116155
66MP0004197_abnormal_fetal_growth/weight/1.05822186
67MP0000313_abnormal_cell_death1.04333285
68MP0000358_abnormal_cell_content/1.02840821
69MP0003123_paternal_imprinting1.01572231
70MP0000026_abnormal_inner_ear1.00242449
71MP0005248_abnormal_Harderian_gland1.00187006
72MP0002735_abnormal_chemical_nociception0.99072836
73MP0005623_abnormal_meninges_morphology0.98995481
74MP0003315_abnormal_perineum_morphology0.98795461
75MP0005551_abnormal_eye_electrophysiolog0.98528403
76MP0003646_muscle_fatigue0.98387176
77MP0001984_abnormal_olfaction0.95452319
78MP0009115_abnormal_fat_cell0.94879606
79MP0001968_abnormal_touch/_nociception0.93119227
80MP0002229_neurodegeneration0.90107446
81MP0006035_abnormal_mitochondrial_morpho0.84153497
82MP0000955_abnormal_spinal_cord0.80204885
83MP0002822_catalepsy0.79589187
84MP0002269_muscular_atrophy0.77922195
85MP0006292_abnormal_olfactory_placode0.77821692
86MP0005647_abnormal_sex_gland0.77142668
87MP0000681_abnormal_thyroid_gland0.76154199
88MP0001119_abnormal_female_reproductive0.76127645
89MP0002067_abnormal_sensory_capabilities0.75716705
90MP0005266_abnormal_metabolism0.75301702
91MP0008995_early_reproductive_senescence0.74454315
92MP0003950_abnormal_plasma_membrane0.73747920
93MP0003699_abnormal_female_reproductive0.73432680
94MP0001849_ear_inflammation0.73004429
95MP0002019_abnormal_tumor_incidence0.72859879
96MP0008569_lethality_at_weaning0.72704084
97MP0005395_other_phenotype0.72630245
98MP0003878_abnormal_ear_physiology0.72330624
99MP0005377_hearing/vestibular/ear_phenot0.72330624
100MP0006036_abnormal_mitochondrial_physio0.71982695
101MP0009697_abnormal_copulation0.71847591
102MP0005375_adipose_tissue_phenotype0.70889671
103MP0003283_abnormal_digestive_organ0.70727095
104MP0002557_abnormal_social/conspecific_i0.69691478
105MP0002282_abnormal_trachea_morphology0.69202577
106MP0003186_abnormal_redox_activity0.68453740
107MP0005253_abnormal_eye_physiology0.67870681
108MP0002733_abnormal_thermal_nociception0.66428207
109MP0000049_abnormal_middle_ear0.65562415
110MP0004085_abnormal_heartbeat0.65456742
111MP0005636_abnormal_mineral_homeostasis0.65425190
112MP0003936_abnormal_reproductive_system0.62879873
113MP0000566_synostosis0.62521839
114MP0001545_abnormal_hematopoietic_system0.61477466
115MP0005397_hematopoietic_system_phenotyp0.61477466
116MP0005167_abnormal_blood-brain_barrier0.60167304
117MP0001919_abnormal_reproductive_system0.59919568
118MP0005083_abnormal_biliary_tract0.59806230
119MP0000490_abnormal_crypts_of0.59125238
120MP0001879_abnormal_lymphatic_vessel0.59078318
121MP0000003_abnormal_adipose_tissue0.58495688
122MP0002572_abnormal_emotion/affect_behav0.57798107
123MP0003861_abnormal_nervous_system0.57088825
124MP0008789_abnormal_olfactory_epithelium0.56115257
125MP0005076_abnormal_cell_differentiation0.56082394
126MP0002796_impaired_skin_barrier0.54756135
127MP0001666_abnormal_nutrient_absorption0.54734099
128MP0001764_abnormal_homeostasis0.53728190
129MP0004484_altered_response_of0.51105805
130MP0003137_abnormal_impulse_conducting0.50379346
131MP0002132_abnormal_respiratory_system0.50158325
132MP0001661_extended_life_span0.48611476
133MP0001440_abnormal_grooming_behavior0.47922203
134MP0002092_abnormal_eye_morphology0.47796674
135MP0005075_abnormal_melanosome_morpholog0.47571798
136MP0005384_cellular_phenotype0.47472170
137MP0002272_abnormal_nervous_system0.47422559
138MP0001970_abnormal_pain_threshold0.47369589
139MP0005367_renal/urinary_system_phenotyp0.47121273
140MP0000516_abnormal_urinary_system0.47121273
141MP0003115_abnormal_respiratory_system0.47072595
142MP0003880_abnormal_central_pattern0.45912245
143MP0010329_abnormal_lipoprotein_level0.45680359
144MP0004019_abnormal_vitamin_homeostasis0.45189175
145MP0002111_abnormal_tail_morphology0.45106042
146MP0001905_abnormal_dopamine_level0.44826266
147MP0004264_abnormal_extraembryonic_tissu0.44724084
148MP0000230_abnormal_systemic_arterial0.44483341
149MP0000432_abnormal_head_morphology0.44406496
150MP0005535_abnormal_body_temperature0.44279413
151MP0009278_abnormal_bone_marrow0.43853424
152MP0005391_vision/eye_phenotype0.43638897
153MP0005332_abnormal_amino_acid0.43458363
154MP0005666_abnormal_adipose_tissue0.43410349
155MP0002734_abnormal_mechanical_nocicepti0.42434616
156MP0008961_abnormal_basal_metabolism0.42419285
157MP0009703_decreased_birth_body0.42206169
158MP0004036_abnormal_muscle_relaxation0.42131348
159MP0005501_abnormal_skin_physiology0.41867029
160MP0001501_abnormal_sleep_pattern0.41728322
161MP0006072_abnormal_retinal_apoptosis0.41511071
162MP0001727_abnormal_embryo_implantation0.40744545
163MP0003567_abnormal_fetal_cardiomyocyte0.40732009
164MP0005394_taste/olfaction_phenotype0.40486088
165MP0005499_abnormal_olfactory_system0.40486088
166MP0000750_abnormal_muscle_regeneration0.39924089
167MP0010030_abnormal_orbit_morphology0.39889863
168MP0000249_abnormal_blood_vessel0.39822642
169MP0000470_abnormal_stomach_morphology0.39270384
170MP0009745_abnormal_behavioral_response0.37804322
171MP0005408_hypopigmentation0.36670678
172MP0003631_nervous_system_phenotype0.35589275
173MP0002928_abnormal_bile_duct0.33731355
174MP0003329_amyloid_beta_deposits0.33150267

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.80042529
2Absent/shortened dynein arms (HP:0200106)9.80042529
3Severe visual impairment (HP:0001141)7.94358950
4Abnormal respiratory epithelium morphology (HP:0012253)7.56218802
5Abnormal respiratory motile cilium morphology (HP:0005938)7.56218802
6Abnormal respiratory motile cilium physiology (HP:0012261)7.43424796
7Rhinitis (HP:0012384)6.10577627
8Abnormal ciliary motility (HP:0012262)6.04095453
9Chronic bronchitis (HP:0004469)5.98445214
10Asymmetric septal hypertrophy (HP:0001670)5.79176177
11Chronic hepatic failure (HP:0100626)5.37525208
12Infertility (HP:0000789)5.03875937
13Attenuation of retinal blood vessels (HP:0007843)4.73574376
14Bony spicule pigmentary retinopathy (HP:0007737)4.69311873
15Resting tremor (HP:0002322)4.56443088
16Nasal polyposis (HP:0100582)4.56307345
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.48697890
18Hyperkalemia (HP:0002153)4.46813154
19Male infertility (HP:0003251)4.36790967
20Cone-rod dystrophy (HP:0000548)4.25275942
21Abnormality of macular pigmentation (HP:0008002)4.18531207
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.89753049
23Impulsivity (HP:0100710)3.85223467
24Bell-shaped thorax (HP:0001591)3.77593808
25Facial shape deformation (HP:0011334)3.64270023
26Potter facies (HP:0002009)3.64270023
27Abnormality of the nasal mucosa (HP:0000433)3.63405297
28Supernumerary spleens (HP:0009799)3.50678291
29Abnormal rod and cone electroretinograms (HP:0008323)3.45339002
30Hypoplasia of the thymus (HP:0000778)3.44770591
31Hypoalphalipoproteinemia (HP:0003233)3.41252735
32Bronchiectasis (HP:0002110)3.39730607
33Progressive sensorineural hearing impairment (HP:0000408)3.39149309
34Enlarged epiphyses (HP:0010580)3.38548542
35Hypoplastic ischia (HP:0003175)3.23617995
36Renovascular hypertension (HP:0100817)3.20434708
37Amelogenesis imperfecta (HP:0000705)3.20109825
38Bronchitis (HP:0012387)3.18683309
39Abnormal spermatogenesis (HP:0008669)3.15087436
40Menstrual irregularities (HP:0000858)3.08188508
41Postural instability (HP:0002172)3.00414858
42Stage 5 chronic kidney disease (HP:0003774)2.99265191
43Abnormality of dental color (HP:0011073)2.93471846
44Abnormality of the ischium (HP:0003174)2.89264894
45Truncal obesity (HP:0001956)2.84075693
46Progressive cerebellar ataxia (HP:0002073)2.82160772
47Birth length less than 3rd percentile (HP:0003561)2.78626616
48Carpal bone hypoplasia (HP:0001498)2.78494687
49Breast hypoplasia (HP:0003187)2.76826580
50Portal hypertension (HP:0001409)2.73327384
51Nephronophthisis (HP:0000090)2.72780346
52Insulin-resistant diabetes mellitus (HP:0000831)2.72500849
53Tubulointerstitial abnormality (HP:0001969)2.71982055
54Unilateral renal agenesis (HP:0000122)2.68724185
55Abnormal urine output (HP:0012590)2.66954048
56Abnormality of the costochondral junction (HP:0000919)2.57415073
57Abnormality of the aortic arch (HP:0012303)2.54989629
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.53251491
59Aplasia/hypoplasia of the humerus (HP:0006507)2.51464074
60Generalized aminoaciduria (HP:0002909)2.50409996
61Abnormality of the hepatic vasculature (HP:0006707)2.50381275
62Abnormality of potassium homeostasis (HP:0011042)2.50270578
63Double outlet right ventricle (HP:0001719)2.46027252
64Congenital malformation of the right heart (HP:0011723)2.46027252
65Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44670970
66Absent radius (HP:0003974)2.42734471
67Tongue fasciculations (HP:0001308)2.41110501
68Ependymoma (HP:0002888)2.39148051
69Polydipsia (HP:0001959)2.36933588
70Abnormal drinking behavior (HP:0030082)2.36933588
71Degeneration of anterior horn cells (HP:0002398)2.36605675
72Abnormality of the anterior horn cell (HP:0006802)2.36605675
73Recurrent otitis media (HP:0000403)2.33940770
74Ventricular tachycardia (HP:0004756)2.33505414
75Renal dysplasia (HP:0000110)2.32670628
76Abnormality of renal excretion (HP:0011036)2.29831502
77Recurrent sinusitis (HP:0011108)2.26861678
78Absent forearm bone (HP:0003953)2.26778280
79Aplasia involving forearm bones (HP:0009822)2.26778280
80Focal segmental glomerulosclerosis (HP:0000097)2.26351094
81Facial cleft (HP:0002006)2.25187210
82Oral leukoplakia (HP:0002745)2.23985727
83Osteomalacia (HP:0002749)2.23462813
84Short humerus (HP:0005792)2.22305065
85Medial flaring of the eyebrow (HP:0010747)2.20704919
86Abnormality of the lower motor neuron (HP:0002366)2.18965563
87Muscle fibrillation (HP:0010546)2.18920250
88Hyperuricemia (HP:0002149)2.18708318
89Increased purine levels (HP:0004368)2.18708318
90Meckel diverticulum (HP:0002245)2.16944671
91Selective tooth agenesis (HP:0001592)2.16822034
92Absent thumb (HP:0009777)2.16080749
93Abdominal situs inversus (HP:0003363)2.15890220
94Abnormality of abdominal situs (HP:0011620)2.15890220
95Abnormality of the ileum (HP:0001549)2.15832608
96Progressive hearing impairment (HP:0001730)2.14872695
97Polyuria (HP:0000103)2.13104017
98Abnormality of midbrain morphology (HP:0002418)2.12915932
99Molar tooth sign on MRI (HP:0002419)2.12915932
100Rough bone trabeculation (HP:0100670)2.12659390
101Intellectual disability, moderate (HP:0002342)2.08651502
102Flattened epiphyses (HP:0003071)2.06871906
103Medulloblastoma (HP:0002885)2.06210267
104Hypophosphatemic rickets (HP:0004912)2.06001167
105Abnormality of the parathyroid morphology (HP:0011766)2.05263655
106Subcapsular cataract (HP:0000523)2.02760206
107Widely patent fontanelles and sutures (HP:0004492)2.01963247
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3442254
109Azoospermia (HP:0000027)1.99108335
110Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98684468
111Myokymia (HP:0002411)1.98630807
112Sloping forehead (HP:0000340)1.97485572
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.95890060
114Abnormality of the preputium (HP:0100587)1.94514466
115Hyponatremia (HP:0002902)1.94396587
116Pancreatic cysts (HP:0001737)1.90871663
117Recurrent pneumonia (HP:0006532)1.90079826
118Abnormality of the renal medulla (HP:0100957)1.89976421
119Abnormality of the labia minora (HP:0012880)1.88070133
120Abnormality of the epiphysis of the femoral head (HP:0010574)1.87455021
121Pancreatic fibrosis (HP:0100732)1.85711526
122Optic nerve hypoplasia (HP:0000609)1.85504102
123Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85381256
124Renal Fanconi syndrome (HP:0001994)1.83754025
125Chromsome breakage (HP:0040012)1.81441879
126Bradycardia (HP:0001662)1.81231840
127Premature ovarian failure (HP:0008209)1.80381557
128Epiphyseal dysplasia (HP:0002656)1.79426926
129Cleft eyelid (HP:0000625)1.79355453
130Decreased central vision (HP:0007663)1.78555488
131Cerebral hypomyelination (HP:0006808)1.78079172
132Glomerulosclerosis (HP:0000096)1.77355957
133Patellar aplasia (HP:0006443)1.77279737
134Hyperthyroidism (HP:0000836)1.75361635
135Hypoparathyroidism (HP:0000829)1.74999744
136Photophobia (HP:0000613)1.74947943
137Postaxial foot polydactyly (HP:0001830)1.74809970
138Tubulointerstitial nephritis (HP:0001970)1.73983895
139Neoplasm of the oral cavity (HP:0100649)1.73747056
140Abnormality of femoral epiphyses (HP:0006499)1.73536686
141Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.73536686
142Agnosia (HP:0010524)1.71491875
143Recurrent corneal erosions (HP:0000495)1.70597605
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70168545
145Absent epiphyses (HP:0010577)1.70168545
146Tetany (HP:0001281)1.69631514
147Median cleft lip (HP:0000161)1.69146041
148Rectal fistula (HP:0100590)1.69009329
149Rectovaginal fistula (HP:0000143)1.69009329
150Tubular atrophy (HP:0000092)1.68057370
151Hypoalbuminemia (HP:0003073)1.67642285
152Abnormality of chromosome stability (HP:0003220)1.67111665
153Small intestinal stenosis (HP:0012848)1.66583011
154Duodenal stenosis (HP:0100867)1.66583011
155Aplasia/Hypoplasia of the patella (HP:0006498)1.66049552
156Gonadotropin excess (HP:0000837)1.62837650
157Bone marrow hypocellularity (HP:0005528)1.62190807
158Congenital primary aphakia (HP:0007707)1.61983151
159Personality changes (HP:0000751)1.57220016
160Short ribs (HP:0000773)1.56529013
161Gait imbalance (HP:0002141)1.55641258
162Type 2 muscle fiber atrophy (HP:0003554)1.54886456
163Congenital hepatic fibrosis (HP:0002612)1.54864700
164Atrophy/Degeneration involving motor neurons (HP:0007373)1.54166810
165Rib fusion (HP:0000902)1.54004088
166Rhabdomyosarcoma (HP:0002859)1.53729708
167Astrocytoma (HP:0009592)1.53710632
168Abnormality of the astrocytes (HP:0100707)1.53710632
169Hypoplasia of the radius (HP:0002984)1.52840269
170Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.52707392
171Abnormal ventriculo-arterial connection (HP:0011563)1.51820631
172Transposition of the great arteries (HP:0001669)1.51820631
173Abnormal connection of the cardiac segments (HP:0011545)1.51820631
174Tracheoesophageal fistula (HP:0002575)1.50663561
175Amyotrophic lateral sclerosis (HP:0007354)1.50519562
176Oculomotor apraxia (HP:0000657)1.49505478
177Asplenia (HP:0001746)1.48861376
178Premature graying of hair (HP:0002216)1.48393184
179Neoplasm of the pancreas (HP:0002894)1.47656213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.27197559
2PDK46.27197559
3PDK24.36472335
4INSRR4.31657865
5TESK13.77432835
6WEE13.66089405
7PLK23.56120712
8BUB13.26293234
9ICK3.10128951
10PNCK3.09428795
11MAP4K23.06780686
12NEK22.53461724
13PRKD32.51822577
14CAMK1G2.37823812
15EPHA22.37732084
16TTK2.34508443
17PIK3CG2.16353541
18PLK42.04442824
19CDC71.84206984
20NEK11.74539801
21EIF2AK11.72385071
22CDK121.66953454
23TESK21.63560694
24PLK11.62894239
25PDPK11.61136881
26CHEK21.58985469
27WNK11.56292969
28MAP3K91.48942245
29DYRK31.48890656
30MST1R1.47405953
31BRSK21.44521771
32SRPK11.42261516
33AKT31.33434113
34KSR21.21901116
35STK38L1.21214994
36TSSK61.17975127
37STK381.13283610
38STK161.10643478
39ATR1.06001542
40AURKA1.05599965
41CDK71.03553846
42CHEK11.02508767
43RPS6KB21.00415992
44PLK30.97531444
45PASK0.94166989
46PINK10.92562555
47PAK40.91193717
48CAMK1D0.89441172
49EIF2AK30.87122667
50AURKB0.86931617
51ARAF0.82635266
52MAPKAPK30.78106954
53TYRO30.77730782
54DYRK1B0.77394177
55BRSK10.76712574
56PTK2B0.71981400
57PAK10.71566176
58SIK20.68840350
59ATM0.68542794
60ZAK0.68503347
61VRK10.67838710
62PRKG20.67509443
63CDK30.65993377
64CCNB10.65886880
65BRAF0.64670805
66MAP3K80.64041655
67MAPK150.62849906
68MAP3K130.61004656
69CDK20.60888886
70PRKG10.58932941
71STK30.58610819
72PRKAA20.58555226
73MAP2K20.57752574
74CDK40.56479754
75NME20.56163953
76PRKCI0.55986413
77ACVR1B0.54910328
78TIE10.54785340
79CAMK10.54002962
80UHMK10.53991504
81RPS6KA20.53962319
82CSNK2A10.53449230
83CSNK2A20.53107228
84TLK10.52342188
85PIM10.51406946
86STK100.49886932
87MAP3K10.49620703
88MAP3K20.48974840
89MTOR0.48849583
90WNK40.48490531
91STK390.45724715
92DYRK20.44758760
93ALK0.44006945
94CDK10.42714842
95LATS20.42486192
96PDK10.41134898
97ROCK10.41009549
98SGK2230.40579222
99SGK4940.40579222
100MAPK10.39501306
101STK40.37952906
102MARK10.37924663
103BMPR1B0.36547522
104SGK10.35685259
105CSNK1E0.35220833
106PBK0.35103464
107LATS10.34795590
108CDK60.33954691
109MAP2K60.33432336
110EEF2K0.33061249
111IRAK10.31988597
112MUSK0.31724733
113PIM20.31458656
114CAMK40.30570566
115MAPK80.29834004
116NTRK30.29620069
117PRKCZ0.26952799
118MKNK20.25065461
119RPS6KL10.24798934
120RPS6KC10.24798934
121BRD40.24137555
122MAPK140.22773063
123YES10.22318298
124RPS6KA60.22244659
125BCKDK0.21608927
126MAP3K110.21467016
127PRKCG0.20406956
128MAPK100.20396943
129EIF2AK20.20162614
130PRKCB0.19732509
131PRKDC0.18821034
132CSNK1D0.18730603
133BLK0.18623288
134MKNK10.18521481
135AKT10.18205892
136GSK3B0.17964285
137MOS0.17927964
138NEK60.17865913
139MET0.17723283
140NME10.17244292
141GRK10.17087871
142RIPK40.16173007
143MELK0.15755849
144KDR0.14452189
145MARK20.14452093
146RPS6KA10.14273535
147DDR20.14236858
148PRKAA10.14192852
149MAPK110.13053760
150PKN10.12368912
151MAP3K40.12072969
152SGK20.11685714
153OXSR10.11273029
154WNK30.10234143
155CDK11A0.09993508
156JAK30.09624382
157PRKACB0.08780018
158PRKACA0.07784161
159SGK30.07288029
160MAP2K10.06528816
161PRKCE0.04749992
162RIPK10.03588002
163MAP3K70.03572704
164RPS6KA30.03333639
165CAMK2A0.03177734

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.31558002
2Olfactory transduction_Homo sapiens_hsa047403.83633368
3DNA replication_Homo sapiens_hsa030303.83075162
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73133943
5Mismatch repair_Homo sapiens_hsa034303.59116732
6RNA transport_Homo sapiens_hsa030133.37722820
7Proteasome_Homo sapiens_hsa030503.32437491
8Vitamin B6 metabolism_Homo sapiens_hsa007503.08266317
9Basal transcription factors_Homo sapiens_hsa030222.88837797
10Fanconi anemia pathway_Homo sapiens_hsa034602.87042716
11RNA polymerase_Homo sapiens_hsa030202.72749343
12Spliceosome_Homo sapiens_hsa030402.64035054
13Homologous recombination_Homo sapiens_hsa034402.59624777
14Base excision repair_Homo sapiens_hsa034102.49402868
15Pyrimidine metabolism_Homo sapiens_hsa002402.46248265
16Ribosome_Homo sapiens_hsa030102.40685142
17Butanoate metabolism_Homo sapiens_hsa006502.40206990
18Nucleotide excision repair_Homo sapiens_hsa034202.37033189
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.18440614
20Cell cycle_Homo sapiens_hsa041102.04174089
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01184492
22mRNA surveillance pathway_Homo sapiens_hsa030151.90555750
23Pentose phosphate pathway_Homo sapiens_hsa000301.81558114
24Taste transduction_Homo sapiens_hsa047421.81518950
25Type I diabetes mellitus_Homo sapiens_hsa049401.77701529
26Fructose and mannose metabolism_Homo sapiens_hsa000511.75643714
27Allograft rejection_Homo sapiens_hsa053301.73979490
28One carbon pool by folate_Homo sapiens_hsa006701.69885979
29Autoimmune thyroid disease_Homo sapiens_hsa053201.69875146
30Purine metabolism_Homo sapiens_hsa002301.69222487
31Fatty acid biosynthesis_Homo sapiens_hsa000611.68428994
32Oocyte meiosis_Homo sapiens_hsa041141.65385584
33Fatty acid degradation_Homo sapiens_hsa000711.63533764
34Linoleic acid metabolism_Homo sapiens_hsa005911.58340613
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58206918
36Phenylalanine metabolism_Homo sapiens_hsa003601.55643223
37Graft-versus-host disease_Homo sapiens_hsa053321.55520805
38Type II diabetes mellitus_Homo sapiens_hsa049301.54694769
39Selenocompound metabolism_Homo sapiens_hsa004501.53275295
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.48892759
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46841828
42RNA degradation_Homo sapiens_hsa030181.43708071
43Biosynthesis of amino acids_Homo sapiens_hsa012301.41912633
44Pyruvate metabolism_Homo sapiens_hsa006201.41385385
45Huntingtons disease_Homo sapiens_hsa050161.31957693
46Non-homologous end-joining_Homo sapiens_hsa034501.31371982
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27598987
48Carbon metabolism_Homo sapiens_hsa012001.26446135
49Glutathione metabolism_Homo sapiens_hsa004801.25249298
50Viral myocarditis_Homo sapiens_hsa054161.19815714
51p53 signaling pathway_Homo sapiens_hsa041151.18165216
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16719818
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.14381649
54Inositol phosphate metabolism_Homo sapiens_hsa005621.13977640
55Phototransduction_Homo sapiens_hsa047441.12251214
56Endocytosis_Homo sapiens_hsa041441.07457607
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07213622
58Protein digestion and absorption_Homo sapiens_hsa049741.01097663
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.98893489
60Influenza A_Homo sapiens_hsa051640.98608758
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96472382
62Epstein-Barr virus infection_Homo sapiens_hsa051690.95777742
63Salivary secretion_Homo sapiens_hsa049700.95121144
64Propanoate metabolism_Homo sapiens_hsa006400.94376853
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92972683
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.88101451
67cAMP signaling pathway_Homo sapiens_hsa040240.86868045
68Arginine biosynthesis_Homo sapiens_hsa002200.83550377
69Calcium signaling pathway_Homo sapiens_hsa040200.82498984
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82082124
71Morphine addiction_Homo sapiens_hsa050320.81521569
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81491916
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79440593
74Synaptic vesicle cycle_Homo sapiens_hsa047210.78772289
75Arachidonic acid metabolism_Homo sapiens_hsa005900.78142315
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75448078
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75219016
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75184337
79Hedgehog signaling pathway_Homo sapiens_hsa043400.74383914
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74315705
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74289085
82Systemic lupus erythematosus_Homo sapiens_hsa053220.74286884
83Glucagon signaling pathway_Homo sapiens_hsa049220.71966489
84Glycerolipid metabolism_Homo sapiens_hsa005610.71673759
85Antigen processing and presentation_Homo sapiens_hsa046120.70099785
86Estrogen signaling pathway_Homo sapiens_hsa049150.69318941
87ABC transporters_Homo sapiens_hsa020100.68662066
88Glutamatergic synapse_Homo sapiens_hsa047240.66997462
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66450164
90Nicotine addiction_Homo sapiens_hsa050330.66058113
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63612811
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63442323
93Circadian entrainment_Homo sapiens_hsa047130.62451242
94Tyrosine metabolism_Homo sapiens_hsa003500.61888649
95VEGF signaling pathway_Homo sapiens_hsa043700.61723252
96Fat digestion and absorption_Homo sapiens_hsa049750.59620958
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.59436779
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57666373
99Retinol metabolism_Homo sapiens_hsa008300.56292926
100Metabolic pathways_Homo sapiens_hsa011000.55831710
101Renin secretion_Homo sapiens_hsa049240.55518918
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54529300
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.53654570
104Serotonergic synapse_Homo sapiens_hsa047260.53418137
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.52310665
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49896249
107Mineral absorption_Homo sapiens_hsa049780.49701347
108Sulfur relay system_Homo sapiens_hsa041220.47341382
109Cardiac muscle contraction_Homo sapiens_hsa042600.46884117
110Folate biosynthesis_Homo sapiens_hsa007900.46503388
111MAPK signaling pathway_Homo sapiens_hsa040100.46184604
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46125168
113Viral carcinogenesis_Homo sapiens_hsa052030.45990308
114Insulin secretion_Homo sapiens_hsa049110.45689635
115Gastric acid secretion_Homo sapiens_hsa049710.45355136
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44989504
117Ether lipid metabolism_Homo sapiens_hsa005650.42298665
118Galactose metabolism_Homo sapiens_hsa000520.40789880
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.40731348
120Pancreatic secretion_Homo sapiens_hsa049720.40281886
121Bile secretion_Homo sapiens_hsa049760.40002419
122Renin-angiotensin system_Homo sapiens_hsa046140.39820378
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.39378032
124Hippo signaling pathway_Homo sapiens_hsa043900.39095271
125Basal cell carcinoma_Homo sapiens_hsa052170.38487437
126Cholinergic synapse_Homo sapiens_hsa047250.38138143
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37562656
128Long-term potentiation_Homo sapiens_hsa047200.37476670
129Arginine and proline metabolism_Homo sapiens_hsa003300.37099748
130Acute myeloid leukemia_Homo sapiens_hsa052210.37003352
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33500465
132Nitrogen metabolism_Homo sapiens_hsa009100.33468292
133Tight junction_Homo sapiens_hsa045300.29632724
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29074804
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.28673461
136Regulation of autophagy_Homo sapiens_hsa041400.28378340
137Legionellosis_Homo sapiens_hsa051340.28083254
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27249719
139Oxytocin signaling pathway_Homo sapiens_hsa049210.25810743
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24190655
141HTLV-I infection_Homo sapiens_hsa051660.22741050
142Chemical carcinogenesis_Homo sapiens_hsa052040.22369837
143GABAergic synapse_Homo sapiens_hsa047270.22269840
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22261419
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.22067859
146Oxidative phosphorylation_Homo sapiens_hsa001900.21910674
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21281816
148Thyroid hormone synthesis_Homo sapiens_hsa049180.20837739
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20804501
150PPAR signaling pathway_Homo sapiens_hsa033200.20552013
151Parkinsons disease_Homo sapiens_hsa050120.19954836
152Adherens junction_Homo sapiens_hsa045200.19246800
153Amphetamine addiction_Homo sapiens_hsa050310.19035377
154Herpes simplex infection_Homo sapiens_hsa051680.19002055
155B cell receptor signaling pathway_Homo sapiens_hsa046620.17974436
156ECM-receptor interaction_Homo sapiens_hsa045120.17565057
157Collecting duct acid secretion_Homo sapiens_hsa049660.14678814
158Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14404655
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13110852
160AMPK signaling pathway_Homo sapiens_hsa041520.11204067
161HIF-1 signaling pathway_Homo sapiens_hsa040660.10643825
162Wnt signaling pathway_Homo sapiens_hsa043100.08945366
163mTOR signaling pathway_Homo sapiens_hsa041500.08451399
164Fatty acid metabolism_Homo sapiens_hsa012120.07264645
165Pentose and glucuronate interconversions_Homo sapiens_hsa000400.07060367
166Dorso-ventral axis formation_Homo sapiens_hsa043200.06206018

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