GUCA1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)9.29477009
2* visual perception (GO:0007601)8.81360840
3* sensory perception of light stimulus (GO:0050953)8.70743164
4* positive regulation of guanylate cyclase activity (GO:0031284)7.65028080
5retinal rod cell development (GO:0046548)7.53889621
6* detection of external stimulus (GO:0009581)7.17756592
7* regulation of guanylate cyclase activity (GO:0031282)7.09828617
8* cellular response to light stimulus (GO:0071482)7.04578236
9* detection of abiotic stimulus (GO:0009582)7.03081857
10retina development in camera-type eye (GO:0060041)6.16718595
11photoreceptor cell differentiation (GO:0046530)5.55769046
12eye photoreceptor cell differentiation (GO:0001754)5.55769046
13detection of chemical stimulus involved in sensory perception of taste (GO:0050912)5.40703278
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.10394925
15receptor guanylyl cyclase signaling pathway (GO:0007168)4.90426205
16detection of chemical stimulus involved in sensory perception (GO:0050907)4.84461811
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76797349
18positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)4.75935563
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.74832649
20* regulation of cGMP metabolic process (GO:0030823)4.73627986
21positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)4.62728848
22chaperone-mediated protein transport (GO:0072321)4.58837959
23* cellular response to radiation (GO:0071478)4.57574877
24adaptation of signaling pathway (GO:0023058)4.52857787
25CDP-diacylglycerol biosynthetic process (GO:0016024)4.43420445
26nonmotile primary cilium assembly (GO:0035058)4.42401661
27single strand break repair (GO:0000012)4.40173730
28protein neddylation (GO:0045116)4.39349430
29positive regulation of ERBB signaling pathway (GO:1901186)4.38340139
30CDP-diacylglycerol metabolic process (GO:0046341)4.37326679
31chromatin remodeling at centromere (GO:0031055)4.33844868
32estrogen biosynthetic process (GO:0006703)4.15137566
33histone exchange (GO:0043486)4.08283012
34energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04695887
35ATP synthesis coupled proton transport (GO:0015986)4.04695887
36CENP-A containing nucleosome assembly (GO:0034080)4.02291331
37* positive regulation of cGMP biosynthetic process (GO:0030828)4.01091118
38establishment of integrated proviral latency (GO:0075713)4.00018879
39proteasome assembly (GO:0043248)3.99523538
40* sensory perception (GO:0007600)3.97844796
41* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.95656850
42L-serine metabolic process (GO:0006563)3.94583131
43* response to light stimulus (GO:0009416)3.93688521
44regulation of helicase activity (GO:0051095)3.92100087
45* regulation of cGMP biosynthetic process (GO:0030826)3.90028902
46ribosomal small subunit assembly (GO:0000028)3.82809602
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.67212950
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.64753201
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.64753201
50regulation of penile erection (GO:0060405)3.63644524
51regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.59987398
52regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.59987398
53cell morphogenesis involved in neuron differentiation (GO:0048667)3.55711090
54short-term memory (GO:0007614)3.53648775
55sperm motility (GO:0030317)3.53030427
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.51876017
57DNA double-strand break processing (GO:0000729)3.51593430
58negative regulation of transcription regulatory region DNA binding (GO:2000678)3.50504134
59chemosensory behavior (GO:0007635)3.48550475
60rRNA modification (GO:0000154)3.45911065
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.45528362
62termination of RNA polymerase III transcription (GO:0006386)3.45528362
63neuron development (GO:0048666)3.45172918
64behavioral response to ethanol (GO:0048149)3.43343257
65retinoid metabolic process (GO:0001523)3.39488963
66* positive regulation of cGMP metabolic process (GO:0030825)3.39304483
67spliceosomal snRNP assembly (GO:0000387)3.37687594
68DNA replication-independent nucleosome organization (GO:0034724)3.35146936
69DNA replication-independent nucleosome assembly (GO:0006336)3.35146936
70response to histamine (GO:0034776)3.33102709
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27456343
72DNA damage response, detection of DNA damage (GO:0042769)3.25783730
73establishment of viral latency (GO:0019043)3.24818105
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21987794
75regulation of voltage-gated calcium channel activity (GO:1901385)3.21731600
76protein prenylation (GO:0018342)3.20488031
77prenylation (GO:0097354)3.20488031
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20155196
79regulation of mitochondrial translation (GO:0070129)3.18030323
80spermatid development (GO:0007286)3.16884511
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14867801
82regulation of clathrin-mediated endocytosis (GO:2000369)3.14220248
83rRNA methylation (GO:0031167)3.12191253
84diterpenoid metabolic process (GO:0016101)3.11325954
85positive regulation of sodium ion transmembrane transport (GO:1902307)3.09109181
86viral transcription (GO:0019083)3.07218797
87translational termination (GO:0006415)3.03437569
88respiratory electron transport chain (GO:0022904)3.03257324
89DNA replication checkpoint (GO:0000076)3.03243666
90regulation of mitotic spindle checkpoint (GO:1903504)3.02793243
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02793243
92negative regulation of DNA recombination (GO:0045910)3.00402058
93retinal cone cell development (GO:0046549)21.6853527
94regulation of cilium movement (GO:0003352)2.99438878
95regulation of posttranscriptional gene silencing (GO:0060147)2.97128459
96regulation of gene silencing by miRNA (GO:0060964)2.97128459
97regulation of gene silencing by RNA (GO:0060966)2.97128459
98electron transport chain (GO:0022900)2.94507711
99retina layer formation (GO:0010842)2.91750160
100paraxial mesoderm development (GO:0048339)2.91682777
101heterochromatin organization (GO:0070828)2.90554580
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88989427
103ribosomal large subunit biogenesis (GO:0042273)2.88801379
104acrosome reaction (GO:0007340)2.88524259
105terpenoid metabolic process (GO:0006721)2.88389613
106icosanoid secretion (GO:0032309)2.85292799
107arachidonic acid secretion (GO:0050482)2.85292799
108regulation of centriole replication (GO:0046599)2.85180188
109purine nucleobase biosynthetic process (GO:0009113)2.84966406
110negative regulation of DNA-dependent DNA replication (GO:2000104)2.84812282
111negative regulation of ligase activity (GO:0051352)2.83714598
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83714598
113IMP biosynthetic process (GO:0006188)2.82918409
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81307551
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81307551
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81307551
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.81307551
118negative regulation of sister chromatid segregation (GO:0033046)2.81307551
119positive regulation of neurotransmitter transport (GO:0051590)2.80712507
120spliceosomal complex assembly (GO:0000245)2.79521370
121histone mRNA metabolic process (GO:0008334)2.77428776
122* response to radiation (GO:0009314)2.76961900
123DNA strand elongation involved in DNA replication (GO:0006271)2.73635482
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.73235292
125retina homeostasis (GO:0001895)2.72975269
126negative regulation of chromosome segregation (GO:0051985)2.72711908
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71518722
128IMP metabolic process (GO:0046040)2.70760338
129ATP-dependent chromatin remodeling (GO:0043044)2.70668976
130serine family amino acid biosynthetic process (GO:0009070)2.70512594
131cotranslational protein targeting to membrane (GO:0006613)2.68276284
132telomere maintenance via semi-conservative replication (GO:0032201)2.67889202
133translational elongation (GO:0006414)2.67220215
134protein complex biogenesis (GO:0070271)2.66071941
135post-embryonic morphogenesis (GO:0009886)2.65878431
136mitochondrial respiratory chain complex assembly (GO:0033108)2.63493265
137translational initiation (GO:0006413)2.61344069
138protein targeting to ER (GO:0045047)2.60975557
139outer ear morphogenesis (GO:0042473)2.60281580
140epithelial cilium movement (GO:0003351)2.60271185
141non-recombinational repair (GO:0000726)2.59998932
142double-strand break repair via nonhomologous end joining (GO:0006303)2.59998932
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59797638
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59683845
145microtubule depolymerization (GO:0007019)2.59277125
146negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.57966490
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.57966490
148regulation of translation, ncRNA-mediated (GO:0045974)2.57966490
149nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57175652
150kinetochore assembly (GO:0051382)2.57138619
151cullin deneddylation (GO:0010388)2.54707736
152lung-associated mesenchyme development (GO:0060484)2.54244849
153DNA strand elongation (GO:0022616)2.54028568
154protein-cofactor linkage (GO:0018065)2.52828180
155respiratory chain complex IV assembly (GO:0008535)2.52627215
156regulation of cell fate specification (GO:0042659)2.52273552
157synaptic transmission, dopaminergic (GO:0001963)2.49908079
158establishment of protein localization to endoplasmic reticulum (GO:0072599)2.49717850
159protein polyglutamylation (GO:0018095)2.49470282
160membrane hyperpolarization (GO:0060081)2.48413043
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48285932
162NADH dehydrogenase complex assembly (GO:0010257)2.48285932
163startle response (GO:0001964)2.39726167
164righting reflex (GO:0060013)2.39339581
165negative regulation of receptor-mediated endocytosis (GO:0048261)2.37911246
166positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.36185458
167behavioral response to cocaine (GO:0048148)2.34469150
168isoprenoid metabolic process (GO:0006720)2.33008770
169fatty acid elongation (GO:0030497)2.30448610
170* cellular response to abiotic stimulus (GO:0071214)2.28076910
171regulation of neurotransmitter uptake (GO:0051580)2.27198729
172regulation of proton transport (GO:0010155)2.26888846
173mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.26756503
174positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.26756503
175positive regulation of cytokinesis (GO:0032467)2.26636100
176regulation of short-term neuronal synaptic plasticity (GO:0048172)2.24595377
177fatty acid derivative transport (GO:1901571)2.20366861
178icosanoid transport (GO:0071715)2.20366861
179regulation of transcription regulatory region DNA binding (GO:2000677)2.18149925
180dopamine receptor signaling pathway (GO:0007212)2.16310081
181establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.15643962
182mitochondrion transport along microtubule (GO:0047497)2.15643962
183axoneme assembly (GO:0035082)2.14946524
184retinol metabolic process (GO:0042572)2.10026182
185lipid translocation (GO:0034204)2.07737129
186phospholipid translocation (GO:0045332)2.07737129
187regulation of dopamine metabolic process (GO:0042053)2.05380102
188* regulation of rhodopsin mediated signaling pathway (GO:0022400)17.7166395
189* rhodopsin mediated signaling pathway (GO:0016056)17.1152916
190protein-chromophore linkage (GO:0018298)14.1933780
191photoreceptor cell development (GO:0042461)12.8464356
192eye photoreceptor cell development (GO:0042462)12.7195733
193detection of light stimulus involved in visual perception (GO:0050908)12.2424577
194detection of light stimulus involved in sensory perception (GO:0050962)12.2424577
195* phototransduction (GO:0007602)11.1292895
196photoreceptor cell maintenance (GO:0045494)11.0448025
197* phototransduction, visible light (GO:0007603)10.9974996
198* detection of visible light (GO:0009584)10.6469873
199* detection of light stimulus (GO:0009583)10.3864772
200GMP metabolic process (GO:0046037)10.0362279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse6.06557811
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.63265334
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.29443827
4VDR_22108803_ChIP-Seq_LS180_Human4.40976920
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67350658
6E2F7_22180533_ChIP-Seq_HELA_Human3.34573654
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.33347810
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.24989986
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.23551320
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.15311665
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.07730221
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99906728
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60405661
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53942427
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21809069
16ZNF274_21170338_ChIP-Seq_K562_Hela2.16929972
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15057596
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13375524
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02910738
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00904414
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00333672
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98934567
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93590293
24SOX2_16153702_ChIP-ChIP_HESCs_Human1.92799124
25ELK1_19687146_ChIP-ChIP_HELA_Human1.90778794
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85909052
27NANOG_16153702_ChIP-ChIP_HESCs_Human1.85660304
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85091793
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75681007
30CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74991890
31KAP1_22055183_ChIP-Seq_ESCs_Mouse1.69895085
32FUS_26573619_Chip-Seq_HEK293_Human1.68559513
33FOXP3_21729870_ChIP-Seq_TREG_Human1.68013267
34TTF2_22483619_ChIP-Seq_HELA_Human1.66591525
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.66464066
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63938243
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59917472
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59769382
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.58792935
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57206687
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57170435
42ZNF263_19887448_ChIP-Seq_K562_Human1.56372590
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55062077
44EWS_26573619_Chip-Seq_HEK293_Human1.54496906
45SMAD3_21741376_ChIP-Seq_HESCs_Human1.51833564
46P300_19829295_ChIP-Seq_ESCs_Human1.50069757
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50037060
48VDR_23849224_ChIP-Seq_CD4+_Human1.49630330
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46769614
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.46683329
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.43626491
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43369099
53KDM5A_27292631_Chip-Seq_BREAST_Human1.42551389
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42470428
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40496554
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40467954
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39870214
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39617462
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39555214
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37959904
61FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.37333357
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35094305
63XRN2_22483619_ChIP-Seq_HELA_Human1.34716107
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34599588
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34561882
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33397636
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.31809662
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31778332
69SMC4_20622854_ChIP-Seq_HELA_Human1.31028027
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30289195
71* KAP1_27257070_Chip-Seq_ESCs_Mouse1.28715942
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.28143228
73IRF1_19129219_ChIP-ChIP_H3396_Human1.27098486
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.26895734
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26730707
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26341481
77TAF2_19829295_ChIP-Seq_ESCs_Human1.25657290
78CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25346100
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21334757
80TAF15_26573619_Chip-Seq_HEK293_Human1.20147012
81* NANOG_20526341_ChIP-Seq_ESCs_Human1.20023099
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19854617
83CREB1_26743006_Chip-Seq_LNCaP_Human1.18608440
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16450153
85NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.15780182
86P68_20966046_ChIP-Seq_HELA_Human1.15268690
87* YY1_22570637_ChIP-Seq_MALME-3M_Human1.14978943
88CBP_21632823_ChIP-Seq_H3396_Human1.13635129
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12210529
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12112471
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12057605
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.11187435
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.10182069
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09652535
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09160588
96CHD1_26751641_Chip-Seq_LNCaP_Human1.08694341
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08492270
98ERG_20517297_ChIP-Seq_VCAP_Human1.08074532
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07861049
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07682443
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07682443
102TBL1_22424771_ChIP-Seq_293T_Human1.06526002
103SA1_27219007_Chip-Seq_Bcells_Human1.05990222
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.05561661
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05465288
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04642708
107CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04234865
108STAT1_17558387_ChIP-Seq_HELA_Human1.03925034
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.03874787
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03686155
111KDM2B_26808549_Chip-Seq_K562_Human1.02887953
112* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01146046
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00576812
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00340996
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00330271
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00241486
117* DPY_21335234_ChIP-Seq_ESCs_Mouse1.00183903
118PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99548636
119* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99080734
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98173132
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97685062
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.96277720
123DCP1A_22483619_ChIP-Seq_HELA_Human0.96067619
124NCOR_22424771_ChIP-Seq_293T_Human0.95063250
125OCT1_27270436_Chip-Seq_PROSTATE_Human0.94976928
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94820529
127ERA_21632823_ChIP-Seq_H3396_Human0.94133934
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93497591
129EZH2_22144423_ChIP-Seq_EOC_Human0.92800688
130GABP_19822575_ChIP-Seq_HepG2_Human0.92770357
131* AR_20517297_ChIP-Seq_VCAP_Human0.91674578
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91308186
133GATA1_22025678_ChIP-Seq_K562_Human0.91299332
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90411793
135FOXM1_23109430_ChIP-Seq_U2OS_Human0.90217740
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88686260
137OCT4_19829295_ChIP-Seq_ESCs_Human0.88127989
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88045482
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88045482
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88045482
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88026608
142RBPJ_21746931_ChIP-Seq_IB4_Human0.86528655
143* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84261427
144CBP_20019798_ChIP-Seq_JUKART_Human0.83291138
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83291138
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.83112156
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.82722807
148CIITA_25753668_ChIP-Seq_RAJI_Human0.82558031
149IGF1R_20145208_ChIP-Seq_DFB_Human0.82299204
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82171355
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.82167609
152SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81286617
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81026316
154SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80774443
155NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79961382
156KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.79768869
157MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79474566
158CTCF_20526341_ChIP-Seq_ESCs_Human0.79008161
159CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78223205
160NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77691749
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77315511
162CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77103389
163PADI4_21655091_ChIP-ChIP_MCF-7_Human0.76888513
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.76494786
165SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76229792
166* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76222003
167MYC_18940864_ChIP-ChIP_HL60_Human0.76170092
168MYC_19079543_ChIP-ChIP_MESCs_Mouse0.76106065
169GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75559830
170SOX2_21211035_ChIP-Seq_LN229_Human0.75492412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005253_abnormal_eye_physiology7.02430497
2MP0006072_abnormal_retinal_apoptosis6.81428116
3MP0005195_abnormal_posterior_eye3.92053564
4MP0003950_abnormal_plasma_membrane3.65764557
5MP0002090_abnormal_vision3.53111946
6MP0005391_vision/eye_phenotype3.44577872
7MP0001324_abnormal_eye_pigmentation3.37726383
8MP0008877_abnormal_DNA_methylation3.16368275
9MP0003941_abnormal_skin_development2.71341038
10MP0003878_abnormal_ear_physiology2.71231616
11MP0005377_hearing/vestibular/ear_phenot2.71231616
12MP0003136_yellow_coat_color2.69897712
13MP0002229_neurodegeneration2.69031271
14MP0003787_abnormal_imprinting2.53319730
15MP0001764_abnormal_homeostasis2.47198370
16MP0002638_abnormal_pupillary_reflex2.43744682
17MP0005410_abnormal_fertilization2.38460105
18MP0003122_maternal_imprinting2.36877319
19MP0005423_abnormal_somatic_nervous2.22183210
20MP0003121_genomic_imprinting2.14623107
21MP0002938_white_spotting2.09760272
22MP0004133_heterotaxia2.02084442
23MP0003011_delayed_dark_adaptation10.7441954
24* MP0005551_abnormal_eye_electrophysiolog10.1772729
25MP0009379_abnormal_foot_pigmentation1.96667105
26MP0001529_abnormal_vocalization1.94607133
27MP0001986_abnormal_taste_sensitivity1.87994186
28MP0002752_abnormal_somatic_nervous1.87956830
29MP0001485_abnormal_pinna_reflex1.86729707
30MP0004019_abnormal_vitamin_homeostasis1.84785096
31MP0008932_abnormal_embryonic_tissue1.77168935
32MP0003567_abnormal_fetal_cardiomyocyte1.66280819
33MP0010030_abnormal_orbit_morphology1.62306933
34MP0002254_reproductive_system_inflammat1.61901923
35MP0001188_hyperpigmentation1.61140352
36MP0002653_abnormal_ependyma_morphology1.58787626
37MP0003119_abnormal_digestive_system1.52172926
38MP0000049_abnormal_middle_ear1.48488279
39MP0003880_abnormal_central_pattern1.40215824
40MP0001929_abnormal_gametogenesis1.32527091
41MP0002736_abnormal_nociception_after1.27547680
42MP0003937_abnormal_limbs/digits/tail_de1.23844292
43MP0004233_abnormal_muscle_weight1.19534250
44MP0002882_abnormal_neuron_morphology1.18818333
45MP0003123_paternal_imprinting1.18087015
46MP0009697_abnormal_copulation1.16959831
47MP0000465_gastrointestinal_hemorrhage1.12049883
48MP0002697_abnormal_eye_size1.08839761
49MP0000778_abnormal_nervous_system1.07253203
50MP0002751_abnormal_autonomic_nervous1.06897626
51MP0004142_abnormal_muscle_tone1.05686340
52MP0000566_synostosis1.03632368
53MP0003938_abnormal_ear_development1.02140339
54MP0009672_abnormal_birth_weight1.01483538
55MP0004859_abnormal_synaptic_plasticity1.00878851
56MP0006276_abnormal_autonomic_nervous1.00852933
57MP0002085_abnormal_embryonic_tissue1.00321568
58MP0002210_abnormal_sex_determination0.99094834
59MP0002233_abnormal_nose_morphology0.97176790
60MP0002084_abnormal_developmental_patter0.96460068
61MP0000631_abnormal_neuroendocrine_gland0.96169733
62MP0000579_abnormal_nail_morphology0.94507272
63MP0006035_abnormal_mitochondrial_morpho0.93397405
64MP0008004_abnormal_stomach_pH0.93242611
65MP0003861_abnormal_nervous_system0.89664331
66MP0001145_abnormal_male_reproductive0.85951251
67MP0000653_abnormal_sex_gland0.82083955
68MP0005197_abnormal_uvea_morphology0.79176403
69MP0004885_abnormal_endolymph0.78812356
70MP0009840_abnormal_foam_cell0.78333295
71MP0006292_abnormal_olfactory_placode0.78280427
72MP0002837_dystrophic_cardiac_calcinosis0.78170971
73MP0001299_abnormal_eye_distance/0.76331981
74MP0002735_abnormal_chemical_nociception0.75996055
75MP0002111_abnormal_tail_morphology0.75288410
76MP0000955_abnormal_spinal_cord0.75199089
77MP0003186_abnormal_redox_activity0.75170869
78MP0005084_abnormal_gallbladder_morpholo0.74970145
79MP0009703_decreased_birth_body0.73774419
80MP0002282_abnormal_trachea_morphology0.73232293
81MP0003755_abnormal_palate_morphology0.72163159
82MP0002557_abnormal_social/conspecific_i0.71698369
83MP0008872_abnormal_physiological_respon0.71562731
84MP0002332_abnormal_exercise_endurance0.70311121
85MP0001486_abnormal_startle_reflex0.66210154
86MP0002127_abnormal_cardiovascular_syste0.66027173
87MP0001502_abnormal_circadian_rhythm0.64081832
88MP0003693_abnormal_embryo_hatching0.63779706
89MP0001984_abnormal_olfaction0.57505996
90MP0008058_abnormal_DNA_repair0.57339170
91MP0005376_homeostasis/metabolism_phenot0.55905721
92MP0003634_abnormal_glial_cell0.51977669
93MP0003111_abnormal_nucleus_morphology0.51267047
94MP0003646_muscle_fatigue0.48720930
95MP0005187_abnormal_penis_morphology0.47826158
96MP0001286_abnormal_eye_development0.47087953
97MP0001963_abnormal_hearing_physiology0.46001755
98MP0003718_maternal_effect0.45698848
99MP0001661_extended_life_span0.41214176
100MP0003077_abnormal_cell_cycle0.40376474
101MP0005076_abnormal_cell_differentiation0.37548996
102MP0004270_analgesia0.35754275
103MP0002102_abnormal_ear_morphology0.34915545
104MP0008875_abnormal_xenobiotic_pharmacok0.31874404
105MP0010386_abnormal_urinary_bladder0.30700264
106MP0010307_abnormal_tumor_latency0.30067999
107MP0004782_abnormal_surfactant_physiolog0.29877016
108MP0005394_taste/olfaction_phenotype0.29650162
109MP0005499_abnormal_olfactory_system0.29650162
110MP0009333_abnormal_splenocyte_physiolog0.29123596
111MP0005310_abnormal_salivary_gland0.28453356
112MP0002734_abnormal_mechanical_nocicepti0.27708535
113MP0001915_intracranial_hemorrhage0.27028260
114MP0005395_other_phenotype0.24547378
115MP0008007_abnormal_cellular_replicative0.23905340
116MP0002272_abnormal_nervous_system0.23621804
117MP0008057_abnormal_DNA_replication0.23128533
118MP0005386_behavior/neurological_phenoty0.22458205
119MP0004924_abnormal_behavior0.22458205
120MP0001905_abnormal_dopamine_level0.22216891
121MP0008260_abnormal_autophagy0.22067273
122MP0005330_cardiomyopathy0.21817841
123MP0008789_abnormal_olfactory_epithelium0.21325869
124MP0000350_abnormal_cell_proliferation0.20182769
125MP0005365_abnormal_bile_salt0.19615392
126MP0003045_fibrosis0.19323140
127MP0003943_abnormal_hepatobiliary_system0.18874320
128MP0000750_abnormal_muscle_regeneration0.18577156
129MP0004215_abnormal_myocardial_fiber0.17651945
130MP0004742_abnormal_vestibular_system0.17646627
131MP0003638_abnormal_response/metabolism_0.17251975
132MP0001542_abnormal_bone_strength0.16738563
133MP0010094_abnormal_chromosome_stability0.16431381
134MP0003075_altered_response_to0.16261579
135MP0009046_muscle_twitch0.15810965
136MP0004145_abnormal_muscle_electrophysio0.15536876
137MP0000001_mammalian_phenotype0.14530792
138MP0002067_abnormal_sensory_capabilities0.13729534
139MP0004957_abnormal_blastocyst_morpholog0.13501482
140MP0005319_abnormal_enzyme/_coenzyme0.13397719
141MP0005620_abnormal_muscle_contractility0.11553555
142MP0003890_abnormal_embryonic-extraembry0.11513835
143MP0001614_abnormal_blood_vessel0.11477357
144MP0000647_abnormal_sebaceous_gland0.11248639
145MP0002064_seizures0.10936402
146MP0003698_abnormal_male_reproductive0.10573481
147MP0001968_abnormal_touch/_nociception0.10024624
148MP0002572_abnormal_emotion/affect_behav0.09874585
149MP0002168_other_aberrant_phenotype0.09176267
150MP0010368_abnormal_lymphatic_system0.08950953
151MP0002971_abnormal_brown_adipose0.08845206
152MP0000026_abnormal_inner_ear0.08581128
153MP0005193_abnormal_anterior_eye0.08369187
154MP0005621_abnormal_cell_physiology0.08062584
155MP0001730_embryonic_growth_arrest0.08055414
156MP0003699_abnormal_female_reproductive0.07773392
157MP0002161_abnormal_fertility/fecundity0.07714810
158MP0001293_anophthalmia0.06474078

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macular pigmentation (HP:0008002)9.34973126
2Abnormal rod and cone electroretinograms (HP:0008323)9.29099750
3Pigmentary retinal degeneration (HP:0001146)8.94087737
4Central scotoma (HP:0000603)7.84673233
5Pendular nystagmus (HP:0012043)7.56184870
6Attenuation of retinal blood vessels (HP:0007843)7.40710823
7Scotoma (HP:0000575)7.03768191
8Chorioretinal atrophy (HP:0000533)6.82191931
9Decreased central vision (HP:0007663)6.66958434
10Abolished electroretinogram (ERG) (HP:0000550)6.42008018
11Vitreoretinal degeneration (HP:0000655)6.13189757
12* Photophobia (HP:0000613)5.94276481
13Macular degeneration (HP:0000608)5.30000297
14Type II diabetes mellitus (HP:0005978)5.21681926
15Posterior subcapsular cataract (HP:0007787)5.21292735
16Severe visual impairment (HP:0001141)5.21168419
17Choroideremia (HP:0001139)4.63796721
18Septo-optic dysplasia (HP:0100842)4.31708793
19Constricted visual fields (HP:0001133)4.30398166
20Cone-rod dystrophy (HP:0000548)4.21516117
21Retinitis pigmentosa (HP:0000510)4.07827202
22Abnormality of the labia minora (HP:0012880)4.04955462
23Increased corneal curvature (HP:0100692)3.86295209
24Keratoconus (HP:0000563)3.86295209
25Colon cancer (HP:0003003)3.76502074
26Increased hepatocellular lipid droplets (HP:0006565)3.26519567
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.21475432
28Acute necrotizing encephalopathy (HP:0006965)3.19528361
29Subcapsular cataract (HP:0000523)3.07310852
30Progressive visual loss (HP:0000529)3.05270423
31Acute encephalopathy (HP:0006846)3.00648873
32Congenital sensorineural hearing impairment (HP:0008527)2.99049156
33Retinal atrophy (HP:0001105)2.98893897
34Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.83759437
35Lipid accumulation in hepatocytes (HP:0006561)2.82299550
36Renal Fanconi syndrome (HP:0001994)2.78508921
37Absent septum pellucidum (HP:0001331)2.78189839
38Meckel diverticulum (HP:0002245)2.75782860
39Optic nerve hypoplasia (HP:0000609)2.73934711
40Optic disc pallor (HP:0000543)2.71624805
41Reticulocytopenia (HP:0001896)2.70244973
42Mitochondrial inheritance (HP:0001427)2.68798472
43Abnormality of the ileum (HP:0001549)2.65317973
44Abnormality of the septum pellucidum (HP:0007375)2.62679555
45Ependymoma (HP:0002888)2.61025519
46Abnormal lung lobation (HP:0002101)2.60595942
47Abnormal mitochondria in muscle tissue (HP:0008316)2.60079053
48Bilateral microphthalmos (HP:0007633)2.47163185
49Progressive macrocephaly (HP:0004481)2.47033461
50Supernumerary spleens (HP:0009799)2.46715534
51Stenosis of the external auditory canal (HP:0000402)2.41965815
52Increased CSF lactate (HP:0002490)2.40462712
53Nephronophthisis (HP:0000090)2.37975003
54Abnormal number of erythroid precursors (HP:0012131)2.35819111
55Wide nasal bridge (HP:0000431)2.31466838
56Hyperglycinuria (HP:0003108)2.29204125
57Rhabdomyosarcoma (HP:0002859)2.28254123
58Abnormality of cells of the erythroid lineage (HP:0012130)2.27148360
59Myokymia (HP:0002411)2.23820254
60Choanal stenosis (HP:0000452)2.22305116
61Anophthalmia (HP:0000528)2.18274101
62Maternal diabetes (HP:0009800)2.16678988
63Agnosia (HP:0010524)2.15861381
64Growth hormone deficiency (HP:0000824)2.13882035
65Horizontal nystagmus (HP:0000666)2.10850972
66Cerebral edema (HP:0002181)2.10776879
67Hepatocellular necrosis (HP:0001404)2.10641420
68Abnormality of serum amino acid levels (HP:0003112)2.08597826
69Macrocytic anemia (HP:0001972)2.08315020
70Carpal bone hypoplasia (HP:0001498)2.05927569
71Facial cleft (HP:0002006)2.03461442
72Dyschromatopsia (HP:0007641)15.0192074
73Congenital stationary night blindness (HP:0007642)13.4540970
74Bony spicule pigmentary retinopathy (HP:0007737)10.8223275
75Absent rod-and cone-mediated responses on ERG (HP:0007688)10.4138841
76Exertional dyspnea (HP:0002875)1.99757583
77Chronic hepatic failure (HP:0100626)1.98767114
78Abnormality of serine family amino acid metabolism (HP:0010894)1.96048429
79Abnormality of glycine metabolism (HP:0010895)1.96048429
80Medulloblastoma (HP:0002885)1.95497260
81Congenital primary aphakia (HP:0007707)1.94954009
82Gait imbalance (HP:0002141)1.93687487
83Horseshoe kidney (HP:0000085)1.91190504
84Hepatoblastoma (HP:0002884)1.89533646
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.86446819
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.86351258
87Triphalangeal thumb (HP:0001199)1.85689919
88Abnormality of the renal medulla (HP:0100957)1.84747318
89Optic nerve coloboma (HP:0000588)1.82980350
90Abnormality of renal resorption (HP:0011038)1.82302283
91Ectopic kidney (HP:0000086)1.79924783
92Cortical dysplasia (HP:0002539)1.79323612
93Respiratory difficulties (HP:0002880)1.79067107
94Abnormal biliary tract physiology (HP:0012439)1.78869242
95Bile duct proliferation (HP:0001408)1.78869242
96Severe Myopia (HP:0011003)1.77162406
97Nephroblastoma (Wilms tumor) (HP:0002667)1.76903776
98Abnormal hair whorl (HP:0010721)1.76492098
99Abnormality of chromosome stability (HP:0003220)1.75573336
100Breast aplasia (HP:0100783)1.75150845
101Aplasia/Hypoplasia of the breasts (HP:0010311)1.75026809
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.74535833
103Poor suck (HP:0002033)1.74258439
104Bifid tongue (HP:0010297)1.72621381
105Hepatic necrosis (HP:0002605)1.71502708
106Esophageal atresia (HP:0002032)1.71466889
107Leukodystrophy (HP:0002415)1.71165437
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70903602
109Nephrogenic diabetes insipidus (HP:0009806)1.70692790
110Small intestinal stenosis (HP:0012848)1.68348075
111Duodenal stenosis (HP:0100867)1.68348075
112Medial flaring of the eyebrow (HP:0010747)1.65691139
113Poor coordination (HP:0002370)1.64116379
114Polar cataract (HP:0010696)1.54270677
115Optic atrophy (HP:0000648)1.53778246
116Pancreatic fibrosis (HP:0100732)1.44307470
117Interstitial pulmonary disease (HP:0006530)1.41270662
118Vaginal atresia (HP:0000148)1.20999062
119True hermaphroditism (HP:0010459)1.20446728
120Retinal detachment (HP:0000541)1.15440191
121Genital tract atresia (HP:0001827)1.15393133
122Pancreatic cysts (HP:0001737)1.15102594
123Dysdiadochokinesis (HP:0002075)1.14904259
124Genetic anticipation (HP:0003743)1.02821830
125Astigmatism (HP:0000483)0.98366306
126Aplasia/Hypoplasia of the lens (HP:0008063)0.97976576
127Broad foot (HP:0001769)0.89600489
128Chorioretinal coloboma (HP:0000567)0.88840232
129Lymphopenia (HP:0001888)0.86745717
130Anal stenosis (HP:0002025)0.86150845
131Oligodactyly (hands) (HP:0001180)0.84642877
132Aplasia/Hypoplasia of the fovea (HP:0008060)0.82748103
133Hypoplasia of the fovea (HP:0007750)0.82748103
134Truncal ataxia (HP:0002078)0.82231592
135Decreased testicular size (HP:0008734)0.81407134
136Aplasia/Hypoplasia of the tongue (HP:0010295)0.81283801
137Progressive cerebellar ataxia (HP:0002073)0.80965527
138Abnormality of cells of the lymphoid lineage (HP:0012140)0.79105716
139Abnormality of dental color (HP:0011073)0.78797582
140Recurrent sinusitis (HP:0011108)0.78469841
141Abnormality of midbrain morphology (HP:0002418)0.78312193
142Molar tooth sign on MRI (HP:0002419)0.78312193
143Abnormality of the fovea (HP:0000493)0.78013482
144Cystic liver disease (HP:0006706)0.77971120
145Left ventricular hypertrophy (HP:0001712)0.76681793
146Febrile seizures (HP:0002373)0.75078933
147Asthma (HP:0002099)0.74698149
148Cerebellar dysplasia (HP:0007033)0.73120589
149Broad-based gait (HP:0002136)0.72913253
150Mutism (HP:0002300)0.72228277
151Sclerocornea (HP:0000647)0.71386585
152Epileptic encephalopathy (HP:0200134)0.69975433
153Anencephaly (HP:0002323)0.68472997
154Hypermetropia (HP:0000540)0.65318104
155Furrowed tongue (HP:0000221)0.64519812
156Abnormality of the fingertips (HP:0001211)0.64400948
157Corneal dystrophy (HP:0001131)0.61804475
158Birth length less than 3rd percentile (HP:0003561)0.60849567
159Dysmetric saccades (HP:0000641)0.60210833
160Gastrointestinal stroma tumor (HP:0100723)0.59226871
161Gaze-evoked nystagmus (HP:0000640)0.59012471
162Specific learning disability (HP:0001328)0.57043854
163Dental crowding (HP:0000678)0.56509022
164Increased neuronal autofluorescent lipopigment (HP:0002074)0.55608924
165Aplasia/Hypoplasia of the macula (HP:0008059)0.54797407
166Cerebral hypomyelination (HP:0006808)0.54539124
167Abnormal EKG (HP:0003115)0.53695964
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.52567804
169Abnormality of macrophages (HP:0004311)0.52058077
170Pallor (HP:0000980)0.51501866
171Hyperglycinemia (HP:0002154)0.51494746
172Syncope (HP:0001279)0.51324644
173Oligodactyly (HP:0012165)0.50597984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.84017255
2PINK13.55157913
3TNIK3.43344034
4VRK23.03642294
5CDC72.82255416
6MAP4K22.73653961
7AKT32.60168763
8CDK192.49127313
9WNK32.46116582
10TRIM282.29106824
11RPS6KA42.28999374
12DYRK22.17971538
13NME12.00015385
14GRK111.2239652
15PNCK1.98138153
16BCR1.96814043
17WEE11.83207389
18NEK21.81323590
19ADRBK11.77744530
20TTK1.77150081
21BUB11.61799043
22VRK11.61656185
23MAPK121.54604473
24BMPR1B1.53148381
25MAPK71.45552125
26MST41.44086457
27STK381.43863486
28CASK1.34279115
29OXSR11.31396937
30CDK121.29077234
31BCKDK1.26251142
32PASK1.24278381
33MYLK1.23512979
34CAMK1D1.18175755
35STK38L1.15313145
36CAMK1G1.14428904
37TAOK31.13489931
38PLK21.10978682
39CSNK1G11.10585112
40PLK31.06266233
41IRAK21.02488255
42TAF11.01874198
43CSNK1G30.97474618
44BRD40.97129394
45DYRK30.96098026
46HIPK20.96049498
47CHEK20.93184612
48CSNK1D0.92749750
49FGFR10.91750817
50PDK20.90795339
51TGFBR10.88427709
52PAK40.86635903
53EPHA40.86545878
54MAP3K40.84996652
55MINK10.84188816
56MAP3K90.83272505
57SIK20.82786584
58SRPK10.79799953
59UHMK10.79594570
60PRKCG0.78847569
61EIF2AK10.78458174
62CCNB10.78320194
63LATS10.77803609
64CSNK1A1L0.77605893
65CDK30.75029050
66SGK20.74500873
67MKNK20.71847794
68PLK10.69727782
69NTRK20.69317189
70STK390.67814427
71TIE10.64692960
72TESK10.64478724
73CAMKK10.63886820
74ALK0.63594281
75MAP2K70.62259410
76NLK0.61462441
77PRKAA10.60497425
78AURKB0.60430515
79FGFR20.60292788
80ACVR1B0.59765764
81FES0.59192099
82INSRR0.57934154
83BRSK20.56757161
84SGK30.56540768
85NME20.55407807
86RPS6KA50.55138643
87BRAF0.52822708
88TEC0.51727271
89EIF2AK30.51533894
90TSSK60.50986797
91NUAK10.50939399
92CSNK2A10.49635503
93PRKCB0.48769697
94ADRBK20.48609037
95PRKCZ0.47788897
96CAMK10.47716594
97WNK40.46891355
98PRKACG0.46604265
99ATR0.46233036
100CSNK2A20.45876381
101AKT20.45074023
102PRKAA20.45060401
103YES10.44570426
104ERBB20.43824486
105NEK10.42465517
106STK30.41735554
107PRKCE0.41280108
108CHEK10.40786134
109CAMK2D0.40691357
110BMX0.40535767
111SGK2230.40246791
112SGK4940.40246791
113CSNK1A10.39777802
114PAK60.38191349
115CDK10.38055276
116PLK40.38047474
117ARAF0.38000990
118PIM20.37534818
119MAPK100.36734835
120RPS6KA30.35604041
121CDK70.35006207
122CDK20.34846172
123NEK60.34344291
124MAPK40.33070296
125GSK3B0.32725970
126PRKDC0.32073955
127MKNK10.32039844
128CDK140.31712472
129MAPK90.30647961
130CAMK2A0.30417741
131EPHA20.30324080
132MAPK140.29215412
133CDK11A0.28364525
134TLK10.28102269
135MAPK30.28085375
136PRKACB0.27882105
137ZAK0.26384174
138ATM0.25759943
139PRKCH0.25650687
140AURKA0.25646611
141STK40.24178456
142DYRK1A0.23878806
143STK160.22365583
144ABL20.22094879
145CSNK1E0.21630901
146PDK30.20179915
147PDK40.20179915
148PRKACA0.17867305
149EIF2AK20.17786989
150MARK10.17587602
151BRSK10.17335786
152CSNK1G20.15884413
153DYRK1B0.15209030

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.40519740
2Oxidative phosphorylation_Homo sapiens_hsa001903.17092564
3Parkinsons disease_Homo sapiens_hsa050122.91002540
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49045184
5Non-homologous end-joining_Homo sapiens_hsa034502.40279988
6Huntingtons disease_Homo sapiens_hsa050162.38207582
7Homologous recombination_Homo sapiens_hsa034402.22093857
8* Phototransduction_Homo sapiens_hsa0474416.2704030
9Protein export_Homo sapiens_hsa030601.98705375
10Alzheimers disease_Homo sapiens_hsa050101.78971622
11Caffeine metabolism_Homo sapiens_hsa002321.77222552
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67151939
13Nicotine addiction_Homo sapiens_hsa050331.64670408
14Selenocompound metabolism_Homo sapiens_hsa004501.64288708
15Pyruvate metabolism_Homo sapiens_hsa006201.58942329
16Fanconi anemia pathway_Homo sapiens_hsa034601.57956479
17Steroid biosynthesis_Homo sapiens_hsa001001.45672114
18One carbon pool by folate_Homo sapiens_hsa006701.45238679
19Propanoate metabolism_Homo sapiens_hsa006401.43905911
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34328731
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33724033
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24119146
23Purine metabolism_Homo sapiens_hsa002301.11016381
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09498924
25Synaptic vesicle cycle_Homo sapiens_hsa047211.04452414
26Olfactory transduction_Homo sapiens_hsa047401.01349449
27Butanoate metabolism_Homo sapiens_hsa006500.99252308
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95913601
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93540338
30Carbon metabolism_Homo sapiens_hsa012000.92414098
31Vitamin B6 metabolism_Homo sapiens_hsa007500.92260072
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90292486
33Basal cell carcinoma_Homo sapiens_hsa052170.89629233
34Circadian rhythm_Homo sapiens_hsa047100.87086422
35Hedgehog signaling pathway_Homo sapiens_hsa043400.87075020
36Glutathione metabolism_Homo sapiens_hsa004800.86808248
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85351614
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83366558
39Retinol metabolism_Homo sapiens_hsa008300.77049749
40Taste transduction_Homo sapiens_hsa047420.72328811
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.68891284
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64167976
43Fatty acid biosynthesis_Homo sapiens_hsa000610.63538683
44GABAergic synapse_Homo sapiens_hsa047270.62954988
45RNA polymerase_Homo sapiens_hsa030200.62228408
46Fatty acid metabolism_Homo sapiens_hsa012120.61209463
47Hippo signaling pathway_Homo sapiens_hsa043900.59528706
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57773048
49Fatty acid degradation_Homo sapiens_hsa000710.56600762
50Wnt signaling pathway_Homo sapiens_hsa043100.55306334
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.54784173
52beta-Alanine metabolism_Homo sapiens_hsa004100.54304210
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51919323
54Arginine and proline metabolism_Homo sapiens_hsa003300.51711486
55Cholinergic synapse_Homo sapiens_hsa047250.51073613
56ABC transporters_Homo sapiens_hsa020100.49896048
57Fat digestion and absorption_Homo sapiens_hsa049750.49147394
58Peroxisome_Homo sapiens_hsa041460.48427415
59Folate biosynthesis_Homo sapiens_hsa007900.45934331
60Sulfur relay system_Homo sapiens_hsa041220.44147236
61Tight junction_Homo sapiens_hsa045300.43337583
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42431346
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42109185
64Glycerolipid metabolism_Homo sapiens_hsa005610.40944361
65Fatty acid elongation_Homo sapiens_hsa000620.40418213
66Regulation of autophagy_Homo sapiens_hsa041400.39725396
67Fructose and mannose metabolism_Homo sapiens_hsa000510.38164452
68Serotonergic synapse_Homo sapiens_hsa047260.38048761
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38024067
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37987933
71Glutamatergic synapse_Homo sapiens_hsa047240.37690363
72Tryptophan metabolism_Homo sapiens_hsa003800.37611788
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.37302354
74Dopaminergic synapse_Homo sapiens_hsa047280.37244440
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36509488
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34832139
77Morphine addiction_Homo sapiens_hsa050320.32714186
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31462091
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31417759
80Base excision repair_Homo sapiens_hsa034100.31409683
81Phenylalanine metabolism_Homo sapiens_hsa003600.31243068
82RNA transport_Homo sapiens_hsa030130.29825785
83Chemical carcinogenesis_Homo sapiens_hsa052040.29804913
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29225706
85TGF-beta signaling pathway_Homo sapiens_hsa043500.28760609
86Circadian entrainment_Homo sapiens_hsa047130.28096120
87Pyrimidine metabolism_Homo sapiens_hsa002400.27656277
88RNA degradation_Homo sapiens_hsa030180.27327093
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26885427
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26143667
91Vitamin digestion and absorption_Homo sapiens_hsa049770.25894677
92Tyrosine metabolism_Homo sapiens_hsa003500.24760725
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23475881
94Basal transcription factors_Homo sapiens_hsa030220.23224759
95Pentose phosphate pathway_Homo sapiens_hsa000300.23128924
96Proteasome_Homo sapiens_hsa030500.21983612
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21703974
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20541117
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.20496657
100Inositol phosphate metabolism_Homo sapiens_hsa005620.20115563
101Biosynthesis of amino acids_Homo sapiens_hsa012300.19106237
102Adherens junction_Homo sapiens_hsa045200.18349553
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17661368
104Galactose metabolism_Homo sapiens_hsa000520.17659964
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17399591
106Cell cycle_Homo sapiens_hsa041100.17383025
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17288435
108mTOR signaling pathway_Homo sapiens_hsa041500.17111609
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17025976
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16939663
111Spliceosome_Homo sapiens_hsa030400.16836821
112HIF-1 signaling pathway_Homo sapiens_hsa040660.16096525
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15591551
114Arginine biosynthesis_Homo sapiens_hsa002200.15494986
115mRNA surveillance pathway_Homo sapiens_hsa030150.14568819
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14421568
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12990773
118Lysosome_Homo sapiens_hsa041420.12592313
119Oocyte meiosis_Homo sapiens_hsa041140.11922126
120Insulin secretion_Homo sapiens_hsa049110.11541544
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10902234
122Oxytocin signaling pathway_Homo sapiens_hsa049210.10281477
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10227810
124Chemokine signaling pathway_Homo sapiens_hsa040620.10039772
125cAMP signaling pathway_Homo sapiens_hsa040240.09803652
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09745834
127Mismatch repair_Homo sapiens_hsa034300.09095209
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08446896
129Herpes simplex infection_Homo sapiens_hsa051680.06745721
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.06019089
131DNA replication_Homo sapiens_hsa030300.05681285
132Mineral absorption_Homo sapiens_hsa049780.05320300
133Epstein-Barr virus infection_Homo sapiens_hsa051690.03328533
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.02176674
135p53 signaling pathway_Homo sapiens_hsa041150.01996790
136Glucagon signaling pathway_Homo sapiens_hsa049220.01646567
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01510467
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.00854758
139Calcium signaling pathway_Homo sapiens_hsa040200.00688332
140AMPK signaling pathway_Homo sapiens_hsa041520.00647617
141Metabolic pathways_Homo sapiens_hsa011000.00475454
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.00418510
143Lysine degradation_Homo sapiens_hsa003100.00097946
144Gastric acid secretion_Homo sapiens_hsa04971-0.0139747
145Endocytosis_Homo sapiens_hsa04144-0.0133546
146Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0093959
147Nitrogen metabolism_Homo sapiens_hsa00910-0.0083003
148Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0079226
149Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0075099
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0074916
151Alcoholism_Homo sapiens_hsa05034-0.0067402
152Cardiac muscle contraction_Homo sapiens_hsa04260-0.0033546
153Nucleotide excision repair_Homo sapiens_hsa03420-0.0025498
154Linoleic acid metabolism_Homo sapiens_hsa00591-0.0022808
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0005473
156FoxO signaling pathway_Homo sapiens_hsa04068-0.0001482

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