GUCA2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.53359573
2epoxygenase P450 pathway (GO:0019373)7.46106839
3NADH metabolic process (GO:0006734)7.30549875
4lipoprotein transport (GO:0042953)7.04734739
5* regulation of guanylate cyclase activity (GO:0031282)6.31362217
6fructose metabolic process (GO:0006000)5.79085804
7angiotensin maturation (GO:0002003)5.57919906
8regulation of bile acid biosynthetic process (GO:0070857)5.51548344
9opsonization (GO:0008228)5.39552094
10drug metabolic process (GO:0017144)5.39370308
11positive regulation of hair follicle development (GO:0051798)5.38994245
12positive regulation of hair cycle (GO:0042635)5.38994245
13hormone catabolic process (GO:0042447)5.38169485
14regulation of triglyceride catabolic process (GO:0010896)5.35295828
15regulation of systemic arterial blood pressure (GO:0003073)5.29700827
16vitamin A metabolic process (GO:0006776)5.14583401
17regulation of transforming growth factor beta2 production (GO:0032909)5.02911096
18regulation of cardioblast differentiation (GO:0051890)4.95469087
19receptor guanylyl cyclase signaling pathway (GO:0007168)4.92369516
20pathway-restricted SMAD protein phosphorylation (GO:0060389)4.88837661
21cellular glucuronidation (GO:0052695)4.86586784
22drug transmembrane transport (GO:0006855)4.83162325
23intestinal absorption (GO:0050892)4.81023263
24glucuronate metabolic process (GO:0019585)4.78513321
25uronic acid metabolic process (GO:0006063)4.78513321
26diacylglycerol metabolic process (GO:0046339)4.73002913
27very-low-density lipoprotein particle assembly (GO:0034379)4.69376330
28response to hydroperoxide (GO:0033194)4.66299963
29negative regulation of complement activation (GO:0045916)4.54194083
30peptide hormone processing (GO:0016486)4.40772895
31hydrogen peroxide catabolic process (GO:0042744)4.40330873
32urate metabolic process (GO:0046415)4.39290757
33plasma lipoprotein particle assembly (GO:0034377)4.34557906
34gland morphogenesis (GO:0022612)4.33056504
35urea cycle (GO:0000050)4.30862495
36digestion (GO:0007586)4.30510963
37drug transport (GO:0015893)4.27498154
38regulation of vitamin metabolic process (GO:0030656)4.21089906
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.18848793
40regulation of cellular extravasation (GO:0002691)4.17876240
41urea metabolic process (GO:0019627)4.17828650
42vitamin transmembrane transport (GO:0035461)4.17029186
43peptide catabolic process (GO:0043171)4.15922838
44regulation of alkaline phosphatase activity (GO:0010692)4.15285598
45cellular response to nitric oxide (GO:0071732)4.13089362
46intestinal cholesterol absorption (GO:0030299)4.10580536
47sulfate transmembrane transport (GO:1902358)4.10375329
48glucocorticoid biosynthetic process (GO:0006704)4.05510562
49detection of molecule of bacterial origin (GO:0032490)4.03095282
50actin filament depolymerization (GO:0030042)4.02610658
51* positive regulation of guanylate cyclase activity (GO:0031284)3.97026389
52glycolipid catabolic process (GO:0019377)3.96197223
53regulation of macrophage cytokine production (GO:0010935)3.95559271
54cardiac muscle cell proliferation (GO:0060038)3.94752265
55protein-lipid complex assembly (GO:0065005)3.94585928
56vitamin transport (GO:0051180)3.93148200
57lysine catabolic process (GO:0006554)3.91121644
58lysine metabolic process (GO:0006553)3.91121644
59alkaloid metabolic process (GO:0009820)3.90482630
60glycosphingolipid catabolic process (GO:0046479)3.88365463
61drinking behavior (GO:0042756)3.88301094
62drug catabolic process (GO:0042737)3.86803611
63regulation of hair follicle development (GO:0051797)3.86707814
64dopamine biosynthetic process (GO:0042416)3.86180090
65nitrogen cycle metabolic process (GO:0071941)3.84146770
66adhesion of symbiont to host cell (GO:0044650)3.79730442
67virion attachment to host cell (GO:0019062)3.79730442
68negative regulation of protein activation cascade (GO:2000258)3.78509252
69phospholipid efflux (GO:0033700)3.77668519
70regulation of respiratory burst (GO:0060263)3.74337283
71regulation of cholesterol esterification (GO:0010872)3.71054596
72vitamin biosynthetic process (GO:0009110)3.66737504
73* regulation of cGMP biosynthetic process (GO:0030826)3.65208927
74vitamin D metabolic process (GO:0042359)3.63859220
75positive regulation of pseudopodium assembly (GO:0031274)3.63275152
76renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.62723465
77regulation of apoptotic cell clearance (GO:2000425)3.61355780
78positive regulation of lipid catabolic process (GO:0050996)3.60844357
79positive regulation of triglyceride lipase activity (GO:0061365)3.60078839
80positive regulation of lipoprotein lipase activity (GO:0051006)3.60078839
81embryonic digestive tract development (GO:0048566)3.59926160
82nucleoside diphosphate biosynthetic process (GO:0009133)3.57073218
83positive regulation of macrophage activation (GO:0043032)3.56184526
84positive regulation of glycoprotein biosynthetic process (GO:0010560)3.55968742
85response to nitric oxide (GO:0071731)3.55702525
86regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55187476
87sulfate transport (GO:0008272)3.52120611
88positive regulation of T cell apoptotic process (GO:0070234)3.50489108
89positive regulation of epidermis development (GO:0045684)3.49623767
90cellular response to reactive nitrogen species (GO:1902170)3.49455539
91cysteine metabolic process (GO:0006534)3.49374818
92modified amino acid transport (GO:0072337)3.49119426
93cGMP-mediated signaling (GO:0019934)3.48814083
94maintenance of gastrointestinal epithelium (GO:0030277)3.48550252
95positive regulation of odontogenesis (GO:0042482)3.48018723
96glial cell migration (GO:0008347)3.46584289
97nonribosomal peptide biosynthetic process (GO:0019184)3.45661537
98glutathione biosynthetic process (GO:0006750)3.42049247
99sulfur compound transport (GO:0072348)3.40370595
100organic cation transport (GO:0015695)3.39504053
101quinone biosynthetic process (GO:1901663)3.37902441
102calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37895636
103cobalamin metabolic process (GO:0009235)3.37695702
104bile acid metabolic process (GO:0008206)3.35132401
105antibacterial humoral response (GO:0019731)3.33665003
106fat-soluble vitamin biosynthetic process (GO:0042362)3.32176331
107phosphate ion homeostasis (GO:0055062)3.31857364
108trivalent inorganic anion homeostasis (GO:0072506)3.31857364
109sphingomyelin metabolic process (GO:0006684)3.28687668
110phosphate ion transport (GO:0006817)3.28478179
111antimicrobial humoral response (GO:0019730)3.27485955
112glutamine family amino acid biosynthetic process (GO:0009084)3.27419764
113leukocyte migration involved in inflammatory response (GO:0002523)3.26888904
114basement membrane organization (GO:0071711)3.26568857
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26004012
116regulation of pseudopodium assembly (GO:0031272)3.24618475
117glycerol metabolic process (GO:0006071)3.22583355
118glycosylceramide metabolic process (GO:0006677)3.22318805
119oligosaccharide catabolic process (GO:0009313)3.21768767
120positive regulation of glycoprotein metabolic process (GO:1903020)3.21509797
121polyol transport (GO:0015791)3.17792645
122high-density lipoprotein particle remodeling (GO:0034375)3.17316526
123digestive system process (GO:0022600)3.17093070
124leukotriene metabolic process (GO:0006691)3.17067967
125ovulation from ovarian follicle (GO:0001542)3.16080017
126renal absorption (GO:0070293)3.14470773
127adhesion of symbiont to host (GO:0044406)3.13470695
128striated muscle cell proliferation (GO:0014855)3.13181094
129transcytosis (GO:0045056)3.13079312
130ceramide catabolic process (GO:0046514)3.12650161
131* excretion (GO:0007588)3.12428765
132cytidine deamination (GO:0009972)3.11469291
133cytidine metabolic process (GO:0046087)3.11469291
134cytidine catabolic process (GO:0006216)3.11469291
135response to phenylpropanoid (GO:0080184)3.10296624
136sphingolipid catabolic process (GO:0030149)3.09929399
137membrane repolarization during action potential (GO:0086011)3.09670274
138regulation of cholesterol homeostasis (GO:2000188)3.09477086
139decidualization (GO:0046697)3.02391503
140fat-soluble vitamin metabolic process (GO:0006775)3.00027588
141phosphate ion transmembrane transport (GO:0035435)2.97546458
142positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.96062442
143flavonoid metabolic process (GO:0009812)2.93146822
144negative regulation of humoral immune response (GO:0002921)2.92445056
145bile acid and bile salt transport (GO:0015721)2.89140767
146surfactant homeostasis (GO:0043129)2.88184418
147quaternary ammonium group transport (GO:0015697)2.87595463
148hydrogen peroxide metabolic process (GO:0042743)2.86867206
149regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86866228
150lipoprotein metabolic process (GO:0042157)2.84082367
151positive regulation of macrophage differentiation (GO:0045651)2.83418989
152collagen fibril organization (GO:0030199)2.83337967
153regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.81177021
154homocysteine metabolic process (GO:0050667)2.80793286
155regulation of complement activation (GO:0030449)2.78765470
156hypotonic response (GO:0006971)2.74439814
157regulation of systemic arterial blood pressure by hormone (GO:0001990)2.74053710
158regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.74053710
159endocrine process (GO:0050886)2.74053710
160macrophage activation involved in immune response (GO:0002281)2.73342746
161renal system process involved in regulation of blood volume (GO:0001977)2.70379195
162cellular modified amino acid catabolic process (GO:0042219)2.68848024
163apoptotic cell clearance (GO:0043277)2.66700370
164peptide biosynthetic process (GO:0043043)2.64787886
165branching involved in mammary gland duct morphogenesis (GO:0060444)2.64661698
166negative regulation of cytokine production involved in immune response (GO:0002719)2.64527881
167positive regulation of cell adhesion mediated by integrin (GO:0033630)2.64389137
168fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64357172
169glucocorticoid metabolic process (GO:0008211)2.64014036
170positive regulation of p38MAPK cascade (GO:1900745)2.63708667
171exogenous drug catabolic process (GO:0042738)2.63172316
172transepithelial transport (GO:0070633)2.63142727
173muscle cell proliferation (GO:0033002)2.59206523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80745152
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.54943796
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.11520398
4GATA1_22025678_ChIP-Seq_K562_Human2.99613266
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.90142326
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81177916
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.79178379
8CLOCK_20551151_ChIP-Seq_293T_Human2.69791700
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.69713930
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.68534201
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.61345685
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.55993872
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.50894226
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50207375
15* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.47878396
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.46554441
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.44264075
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.31578511
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15603435
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.13383946
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04544271
22SOX2_20726797_ChIP-Seq_SW620_Human2.03315956
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01236313
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93144469
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85570857
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85334705
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.78736222
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78079473
29* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.73237461
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.70197486
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66099147
32* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64116591
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62153700
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.61364083
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.60314567
36RACK7_27058665_Chip-Seq_MCF-7_Human1.56082235
37GATA4_25053715_ChIP-Seq_YYC3_Human1.54627642
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53660784
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53385569
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.51952928
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51407978
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47159012
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39078173
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37767346
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36116719
46* LXR_22292898_ChIP-Seq_THP-1_Human1.32856152
47GATA6_25053715_ChIP-Seq_YYC3_Human1.31893614
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.30664896
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25799347
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.25024126
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24485206
52* SA1_27219007_Chip-Seq_Bcells_Human1.22651228
53CJUN_26792858_Chip-Seq_BT549_Human1.21595998
54* BCL6_27268052_Chip-Seq_Bcells_Human1.21410024
55JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.21073518
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.19539756
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18677817
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16793703
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15645486
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15645486
61* BCOR_27268052_Chip-Seq_Bcells_Human1.14848529
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14465128
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14023295
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13701592
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13334648
66* CDX2_22108803_ChIP-Seq_LS180_Human1.11836673
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.10620533
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09510374
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09368507
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09126051
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08865960
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.08155840
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08036356
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07433020
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06477754
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06338940
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05957926
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05915123
79* CTCF_27219007_Chip-Seq_Bcells_Human1.05257573
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.04860772
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04629913
82KLF5_25053715_ChIP-Seq_YYC3_Human1.03793733
83SMAD3_21741376_ChIP-Seq_HESCs_Human1.03645296
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03559300
85RXR_22108803_ChIP-Seq_LS180_Human1.02888003
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02832874
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.02308353
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02251267
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01942185
90GATA2_19941826_ChIP-Seq_K562_Human1.01156327
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00299438
92HNF4A_19822575_ChIP-Seq_HepG2_Human1.00007421
93* NANOG_20526341_ChIP-Seq_ESCs_Human0.99924114
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99606651
95SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99472475
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99353051
97* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99301769
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99211000
99ZNF263_19887448_ChIP-Seq_K562_Human0.98507339
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97902996
101EGR1_19032775_ChIP-ChIP_M12_Human0.97519960
102TBX20_22328084_ChIP-Seq_HEART_Mouse0.95577686
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.95577686
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95463075
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95463075
106CEBPB_22108803_ChIP-Seq_LS180_Human0.95017145
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94422101
108GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92538251
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92456835
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92264480
111IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91073255
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90860310
113ATF3_27146783_Chip-Seq_COLON_Human0.90646560
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90553789
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90199474
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90199474
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90044676
118CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89924260
119GATA1_19941826_ChIP-Seq_K562_Human0.89705191
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88618752
121IRF8_21731497_ChIP-ChIP_J774_Mouse0.88306787
122STAT1_20625510_ChIP-Seq_HELA_Human0.88255418
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87726483
124P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87422397
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87210813
126DROSHA_22980978_ChIP-Seq_HELA_Human0.87188227
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.86505412
128CREB1_26743006_Chip-Seq_LNCaP_Human0.86467238
129* TP63_22573176_ChIP-Seq_HFKS_Human0.86218702
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85841827
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84980590
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84842931
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84647315
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84636169
135SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83974961
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83887743
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83282717
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83233205
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82745304
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81782756
141VDR_24763502_ChIP-Seq_THP-1_Human0.80563180
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80353609
143PHF8_20622854_ChIP-Seq_HELA_Human0.80322441
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79717121
145SOX2_22085726_ChIP-Seq_NPCs_Mouse0.79251512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.52126925
2MP0002254_reproductive_system_inflammat4.46648692
3MP0008875_abnormal_xenobiotic_pharmacok4.45705041
4MP0006054_spinal_hemorrhage4.30535583
5MP0004147_increased_porphyrin_level4.17613702
6MP0008438_abnormal_cutaneous_collagen3.68558535
7MP0009379_abnormal_foot_pigmentation3.67302921
8MP0004019_abnormal_vitamin_homeostasis3.23475407
9MP0002139_abnormal_hepatobiliary_system3.19925732
10MP0001666_abnormal_nutrient_absorption3.12440210
11MP0003252_abnormal_bile_duct3.08607972
12MP0000604_amyloidosis2.74600240
13MP0010234_abnormal_vibrissa_follicle2.58297402
14MP0001958_emphysema2.55797951
15MP0003329_amyloid_beta_deposits2.45154622
16MP0000681_abnormal_thyroid_gland2.44812820
17* MP0001765_abnormal_ion_homeostasis2.41349532
18MP0004043_abnormal_pH_regulation2.40753962
19MP0009643_abnormal_urine_homeostasis2.36736030
20MP0005332_abnormal_amino_acid2.28057523
21MP0003868_abnormal_feces_composition2.11021245
22MP0008004_abnormal_stomach_pH2.06592584
23MP0005409_darkened_coat_color2.00246458
24MP0000490_abnormal_crypts_of1.97225210
25* MP0005636_abnormal_mineral_homeostasis1.97149694
26MP0004264_abnormal_extraembryonic_tissu1.93524962
27MP0000538_abnormal_urinary_bladder1.88770943
28MP0001756_abnormal_urination1.86053024
29MP0005058_abnormal_lysosome_morphology1.74528849
30MP0003191_abnormal_cellular_cholesterol1.73717679
31MP0010352_gastrointestinal_tract_polyps1.69083076
32MP0005670_abnormal_white_adipose1.64795428
33MP0009840_abnormal_foam_cell1.64732298
34MP0005085_abnormal_gallbladder_physiolo1.62657621
35MP0004272_abnormal_basement_membrane1.61698275
36MP0002138_abnormal_hepatobiliary_system1.61282459
37MP0000462_abnormal_digestive_system1.60445862
38MP0002876_abnormal_thyroid_physiology1.58011019
39* MP0002136_abnormal_kidney_physiology1.51158335
40MP0005167_abnormal_blood-brain_barrier1.48964584
41MP0003566_abnormal_cell_adhesion1.48778717
42MP0003300_gastrointestinal_ulcer1.43905892
43MP0004883_abnormal_blood_vessel1.43626556
44MP0001188_hyperpigmentation1.40730817
45MP0010329_abnormal_lipoprotein_level1.39124112
46MP0001764_abnormal_homeostasis1.36347956
47MP0005275_abnormal_skin_tensile1.34464820
48MP0005365_abnormal_bile_salt1.33836375
49MP0003879_abnormal_hair_cell1.33519778
50* MP0001664_abnormal_digestion1.31003593
51MP0003878_abnormal_ear_physiology1.29813487
52MP0005377_hearing/vestibular/ear_phenot1.29813487
53MP0003718_maternal_effect1.29565012
54MP0002822_catalepsy1.29502436
55MP0001881_abnormal_mammary_gland1.27096442
56MP0003705_abnormal_hypodermis_morpholog1.20429073
57MP0001663_abnormal_digestive_system1.18610087
58MP0003806_abnormal_nucleotide_metabolis1.13229367
59MP0000678_abnormal_parathyroid_gland1.13212291
60MP0001873_stomach_inflammation1.10920843
61MP0005164_abnormal_response_to1.08874211
62MP0005448_abnormal_energy_balance1.07623979
63MP0002089_abnormal_postnatal_growth/wei1.03772050
64MP0003183_abnormal_peptide_metabolism1.02858805
65MP0001849_ear_inflammation1.02159533
66MP0004270_analgesia1.02141709
67MP0002796_impaired_skin_barrier1.01150687
68MP0005535_abnormal_body_temperature1.00657308
69MP0005166_decreased_susceptibility_to0.98710816
70MP0005451_abnormal_body_composition0.95822528
71MP0001501_abnormal_sleep_pattern0.95325765
72MP0005584_abnormal_enzyme/coenzyme_acti0.94145571
73MP0001727_abnormal_embryo_implantation0.93023579
74MP0002971_abnormal_brown_adipose0.92872910
75MP0001177_atelectasis0.92464341
76MP0000249_abnormal_blood_vessel0.91781718
77MP0009764_decreased_sensitivity_to0.90040005
78MP0002098_abnormal_vibrissa_morphology0.88629739
79MP0002135_abnormal_kidney_morphology0.88049207
80MP0002998_abnormal_bone_remodeling0.87179968
81MP0008872_abnormal_physiological_respon0.86393353
82MP0003045_fibrosis0.85323223
83MP0003638_abnormal_response/metabolism_0.84999255
84MP0000013_abnormal_adipose_tissue0.82852584
85MP0001661_extended_life_span0.82447416
86MP0004782_abnormal_surfactant_physiolog0.80429451
87MP0003567_abnormal_fetal_cardiomyocyte0.80320311
88* MP0000230_abnormal_systemic_arterial0.80287087
89MP0002118_abnormal_lipid_homeostasis0.79740542
90MP0009115_abnormal_fat_cell0.79150854
91MP0010386_abnormal_urinary_bladder0.76992406
92MP0001845_abnormal_inflammatory_respons0.74743807
93MP0009384_cardiac_valve_regurgitation0.74303138
94MP0005084_abnormal_gallbladder_morpholo0.73177233
95MP0002396_abnormal_hematopoietic_system0.73122124
96MP0000477_abnormal_intestine_morphology0.72959546
97MP0003866_abnormal_defecation0.71917901
98MP0009785_altered_susceptibility_to0.71624867
99MP0000537_abnormal_urethra_morphology0.71560274
100MP0000534_abnormal_ureter_morphology0.71533064
101MP0000609_abnormal_liver_physiology0.71467975
102MP0002896_abnormal_bone_mineralization0.71143707
103MP0005666_abnormal_adipose_tissue0.70070055
104MP0005501_abnormal_skin_physiology0.69291202
105MP0000751_myopathy0.68209062
106MP0004742_abnormal_vestibular_system0.68050169
107MP0003448_altered_tumor_morphology0.67827082
108MP0008469_abnormal_protein_level0.64466999
109MP0005319_abnormal_enzyme/_coenzyme0.64244623
110MP0005381_digestive/alimentary_phenotyp0.63927157
111MP0004858_abnormal_nervous_system0.62858366
112MP0004885_abnormal_endolymph0.62523200
113MP0004484_altered_response_of0.62432633
114MP0001270_distended_abdomen0.61756307
115MP0001485_abnormal_pinna_reflex0.61126775
116MP0005023_abnormal_wound_healing0.60998132
117MP0010678_abnormal_skin_adnexa0.60434537
118* MP0009642_abnormal_blood_homeostasis0.60081567
119MP0002928_abnormal_bile_duct0.59810060
120MP0000627_abnormal_mammary_gland0.59659949
121MP0003195_calcinosis0.57766247
122MP0002060_abnormal_skin_morphology0.57052339
123MP0002115_abnormal_skeleton_extremities0.56737599
124MP0003724_increased_susceptibility_to0.56725392
125MP0003795_abnormal_bone_structure0.56592531
126MP0010155_abnormal_intestine_physiology0.55933489
127MP0000639_abnormal_adrenal_gland0.55900228
128MP0000858_altered_metastatic_potential0.55035783
129MP0005503_abnormal_tendon_morphology0.54761281
130MP0002160_abnormal_reproductive_system0.54333265
131MP0008961_abnormal_basal_metabolism0.54330070
132MP0009780_abnormal_chondrocyte_physiolo0.53958781
133MP0005334_abnormal_fat_pad0.53823621
134MP0003953_abnormal_hormone_level0.53171998
135MP0006138_congestive_heart_failure0.52398283
136MP0001533_abnormal_skeleton_physiology0.51875856
137MP0002168_other_aberrant_phenotype0.51861398
138MP0002078_abnormal_glucose_homeostasis0.51132569
139MP0002166_altered_tumor_susceptibility0.47739818
140MP0003303_peritoneal_inflammation0.46874913
141MP0000465_gastrointestinal_hemorrhage0.45314595
142MP0009333_abnormal_splenocyte_physiolog0.44816318
143MP0005174_abnormal_tail_pigmentation0.44805726
144MP0006082_CNS_inflammation0.44725894
145MP0005025_abnormal_response_to0.43548133
146MP0000566_synostosis0.42503982
147MP0000015_abnormal_ear_pigmentation0.40144204
148MP0004947_skin_inflammation0.39744094
149MP0003436_decreased_susceptibility_to0.38814469
150MP0008260_abnormal_autophagy0.37051775

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)6.73913948
2Spondylolisthesis (HP:0003302)6.51972391
3Aortic dissection (HP:0002647)6.20650963
4Vascular tortuosity (HP:0004948)6.06612198
5Malnutrition (HP:0004395)5.65594304
6Abnormality of the vitamin B12 metabolism (HP:0004341)5.60669670
7Metabolic alkalosis (HP:0200114)5.40676121
8Hypobetalipoproteinemia (HP:0003563)5.39306057
9Abnormality of vitamin B metabolism (HP:0004340)5.25327725
10Chronic diarrhea (HP:0002028)5.21348513
11Confusion (HP:0001289)4.99326972
12Fat malabsorption (HP:0002630)4.52659621
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.44161521
14Acanthocytosis (HP:0001927)4.23402403
15Abnormality of vitamin metabolism (HP:0100508)4.21024469
16Aortic aneurysm (HP:0004942)4.09869169
17Decreased circulating renin level (HP:0003351)3.80204476
18Gout (HP:0001997)3.78459568
19Hyperactive renin-angiotensin system (HP:0000841)3.77874091
20Autoimmune thrombocytopenia (HP:0001973)3.70428276
21Nausea (HP:0002018)3.65332725
22Pigmentary retinal degeneration (HP:0001146)3.61676243
23Abnormality of chloride homeostasis (HP:0011422)3.58623268
24Abnormality of renin-angiotensin system (HP:0000847)3.50900911
25Abnormality of proline metabolism (HP:0010907)3.48668040
26Hydroxyprolinuria (HP:0003080)3.48668040
27Abnormality of purine metabolism (HP:0004352)3.44396275
28Hypokalemic alkalosis (HP:0001949)3.37550888
29Megaloblastic anemia (HP:0001889)3.26551914
30Increased circulating renin level (HP:0000848)3.25216706
31Premature rupture of membranes (HP:0001788)3.22618886
32Xanthomatosis (HP:0000991)3.22050618
33Cerebral aneurysm (HP:0004944)3.16565893
34Congenital sensorineural hearing impairment (HP:0008527)3.16331155
35Alkalosis (HP:0001948)3.15918572
36Hypomagnesemia (HP:0002917)3.14893883
37Vacuolated lymphocytes (HP:0001922)3.13114222
38Mucopolysacchariduria (HP:0008155)3.09588890
39Urinary glycosaminoglycan excretion (HP:0003541)3.09588890
40Neoplasm of the heart (HP:0100544)3.09399544
41Ulnar bowing (HP:0003031)3.02099229
42Abnormality of magnesium homeostasis (HP:0004921)3.01701649
43Ileus (HP:0002595)3.01587905
44Abnormality of monocarboxylic acid metabolism (HP:0010996)3.01311569
45Widely patent fontanelles and sutures (HP:0004492)2.97722937
46Hyperparathyroidism (HP:0000843)2.97473732
47Steatorrhea (HP:0002570)2.96833232
48Abnormal urine output (HP:0012590)2.95839223
49Systemic lupus erythematosus (HP:0002725)2.92824283
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89509223
51Abnormality of polysaccharide metabolism (HP:0011012)2.89509223
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89509223
53Posterior subcapsular cataract (HP:0007787)2.87636563
54Increased purine levels (HP:0004368)2.85450395
55Hyperuricemia (HP:0002149)2.85450395
56Hyperglycinuria (HP:0003108)2.83773383
57Thin bony cortex (HP:0002753)2.83718912
58Hypophosphatemia (HP:0002148)2.83256983
59Hypokalemia (HP:0002900)2.83161451
60Gastrointestinal dysmotility (HP:0002579)2.82882003
61Abnormality of renal excretion (HP:0011036)2.82275259
62Bicuspid aortic valve (HP:0001647)2.78909130
63Mitral valve prolapse (HP:0001634)2.76150597
64Hypolipoproteinemia (HP:0010981)2.73729863
65Enlarged epiphyses (HP:0010580)2.71427861
66Ankle contracture (HP:0006466)2.68385705
67Dysostosis multiplex (HP:0000943)2.68321481
68Facial shape deformation (HP:0011334)2.64998048
69Potter facies (HP:0002009)2.64998048
70Abnormal urine phosphate concentration (HP:0012599)2.63437072
71Generalized aminoaciduria (HP:0002909)2.63079630
72Hyperammonemia (HP:0001987)2.59793139
73Mesangial abnormality (HP:0001966)2.59306191
74Right ventricular cardiomyopathy (HP:0011663)2.59210131
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55889423
76Petechiae (HP:0000967)2.51590503
77Polyuria (HP:0000103)2.51349400
78Proximal tubulopathy (HP:0000114)2.48362014
79Hemorrhage of the eye (HP:0011885)2.46859190
80Hypotension (HP:0002615)2.43915625
81Hyperaldosteronism (HP:0000859)2.43621432
82Hyperphosphaturia (HP:0003109)2.42967438
83Renal salt wasting (HP:0000127)2.42384492
84Villous atrophy (HP:0011473)2.40584455
85Abnormality of small intestinal villus morphology (HP:0011472)2.40584455
86Focal segmental glomerulosclerosis (HP:0000097)2.38142302
87Abnormality of the costochondral junction (HP:0000919)2.37605038
88Tetany (HP:0001281)2.33760910
89Metabolic acidosis (HP:0001942)2.31115780
90Cervical subluxation (HP:0003308)2.30915844
91Purpura (HP:0000979)2.27709400
92Persistence of primary teeth (HP:0006335)2.25189826
93Flat acetabular roof (HP:0003180)2.25095172
94Nephrolithiasis (HP:0000787)2.24573741
95Abnormality of nucleobase metabolism (HP:0010932)2.23876726
96Eczematoid dermatitis (HP:0000976)2.20557836
97Protuberant abdomen (HP:0001538)2.20108162
98Radial bowing (HP:0002986)2.18086780
99Renal tubular acidosis (HP:0001947)2.16804881
100Abnormality of urine glucose concentration (HP:0011016)2.14510374
101Glycosuria (HP:0003076)2.14510374
102Subcapsular cataract (HP:0000523)2.12751247
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10234134
104Dicarboxylic aciduria (HP:0003215)2.10234134
105Cerebral palsy (HP:0100021)2.08533091
106Epidermoid cyst (HP:0200040)2.08314399
107Delayed epiphyseal ossification (HP:0002663)2.08250514
108Thyroid-stimulating hormone excess (HP:0002925)2.07501879
109Spastic diplegia (HP:0001264)2.05980833
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03975364
111Abnormality of potassium homeostasis (HP:0011042)2.03943638
112Abnormality of serine family amino acid metabolism (HP:0010894)2.03896250
113Abnormality of glycine metabolism (HP:0010895)2.03896250
114Abdominal situs inversus (HP:0003363)2.01690439
115Abnormality of abdominal situs (HP:0011620)2.01690439
116Dehydration (HP:0001944)2.01091940
117Ketoacidosis (HP:0001993)2.00084779
118Glomerulonephritis (HP:0000099)1.99936799
119Hyperphosphatemia (HP:0002905)1.97350132
120Hypercalciuria (HP:0002150)1.97067906
121Wide cranial sutures (HP:0010537)1.95520523
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95341119
123Delayed closure of the anterior fontanelle (HP:0001476)1.93005768
124Fragile skin (HP:0001030)1.92222421
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.91576700
126Conjugated hyperbilirubinemia (HP:0002908)1.90909195
127Bilateral sensorineural hearing impairment (HP:0008619)1.90802843
128Renal tubular dysfunction (HP:0000124)1.90737937
129Bowed forearm bones (HP:0003956)1.90154898
130Bowing of the arm (HP:0006488)1.90154898
131Osteolytic defects of the hand bones (HP:0009699)1.89875823
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.89875823
133Nephritis (HP:0000123)1.89793457
134Growth hormone excess (HP:0000845)1.88963734
135Pancreatitis (HP:0001733)1.88562611
136Abdominal distention (HP:0003270)1.88099648
137Multiple lipomas (HP:0001012)1.87748340
138Type 1 muscle fiber predominance (HP:0003803)1.86919329
139Abnormal glucose tolerance (HP:0001952)1.84824178
140Poikilocytosis (HP:0004447)1.84568511
141Ventricular fibrillation (HP:0001663)1.83087880
142Abnormal drinking behavior (HP:0030082)1.83021703
143Polydipsia (HP:0001959)1.83021703
144Irritability (HP:0000737)1.82881286
145Pili torti (HP:0003777)1.82822495
146Gingivitis (HP:0000230)1.79507970
147Abnormality of alkaline phosphatase activity (HP:0004379)1.77048213
148Abnormal enzyme/coenzyme activity (HP:0012379)1.76633888
149Asymmetric septal hypertrophy (HP:0001670)1.76505482
150Glomerulosclerosis (HP:0000096)1.76076366
151Arachnodactyly (HP:0001166)1.76034040
152Broad metatarsal (HP:0001783)1.74188116
153Aneurysm (HP:0002617)1.73926568
154Abnormality of pyrimidine metabolism (HP:0004353)1.67572007
155Hypoalbuminemia (HP:0003073)1.64901049
156Abnormal albumin level (HP:0012116)1.64901049
157Metaphyseal irregularity (HP:0003025)1.64867706
158Lethargy (HP:0001254)1.63526366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.67082650
2MYLK4.66973156
3TGFBR24.17394209
4WNK43.45878677
5MST1R3.42132580
6TTN3.16043984
7MST43.12702625
8WNK33.10203598
9OXSR12.85555507
10ERN12.84669243
11LMTK22.55910885
12FRK2.21517149
13EPHB12.02997770
14TAOK31.93284037
15TESK21.87164521
16PIK3CG1.83544359
17MAPKAPK31.83461803
18MET1.83298414
19MAP3K101.82941561
20PIK3CA1.76278657
21RIPK11.73958793
22PTK61.66819441
23DMPK1.62081632
24PRKG21.50790219
25PDGFRA1.49924421
26NME11.47265477
27EPHB21.46406976
28PDK21.45749068
29PAK21.45706634
30GRK61.45032241
31MAP3K121.41709117
32LRRK21.40939266
33PTK21.40607420
34TESK11.38966934
35MAP3K21.38654332
36PAK41.35147366
37STK391.32338694
38EPHA41.31301185
39TRIB31.29399978
40DDR21.28163468
41TNIK1.20614520
42FER1.20460805
43STK381.14803518
44MAP4K11.14535249
45MAP3K71.12801304
46DAPK21.07011572
47RIPK41.06608847
48CASK1.01661871
49MATK1.01525114
50FGFR41.00820973
51STK240.96917728
52MAP2K60.95503786
53FGFR20.89456884
54PTK2B0.87682356
55PDPK10.87366650
56LATS10.85909003
57PRPF4B0.85630425
58NTRK10.85298344
59STK100.85046017
60MAP2K20.84727993
61MAP3K110.83004451
62ERBB20.81624859
63BMX0.79996968
64KDR0.74747049
65LIMK10.73290447
66PAK30.73222584
67DYRK1B0.69751426
68PAK10.69524507
69PIM10.69167230
70STK38L0.69006452
71CDC42BPA0.68747159
72ROCK10.68725200
73PRKACG0.68207123
74SGK2230.67868546
75SGK4940.67868546
76GSK3A0.66329796
77PRKCZ0.61402861
78AKT30.60941188
79TIE10.60747370
80SGK30.60683392
81MAPK110.58863457
82MAP3K10.56642942
83PRKCI0.54964836
84ABL20.54538599
85PDK40.52692466
86PDK30.52692466
87PKN20.51529406
88SRC0.51471394
89KSR20.51061496
90TYK20.50794104
91GRK10.50165232
92PDK10.49982889
93MAP3K30.49613020
94WNK10.47205513
95CAMK2D0.46260586
96FGFR30.45857088
97BCKDK0.45039947
98NLK0.44836632
99ROCK20.43158547
100IRAK30.41925050
101NUAK10.40598726
102STK30.39715483
103DAPK30.38785079
104EPHA30.38040433
105CSF1R0.36686518
106PRKCD0.36442128
107PRKAA20.36270350
108JAK30.35885268
109MAPK120.34274635
110EPHA20.33673615
111MELK0.33568696
112MAP2K10.33324149
113PRKD10.32048328
114PDGFRB0.31535824
115NEK10.30823245
116ITK0.30724950
117BMPR20.29554735
118JAK20.28607793
119RET0.28290084
120MAP3K80.27642707
121YES10.27099612
122TBK10.26655167
123BMPR1B0.26544565
124TEC0.26188514
125TAOK10.25340306
126JAK10.25291864
127CSK0.24735551
128FYN0.24107955
129CDK190.23898928
130CAMK2G0.23454726
131MAPK40.23151541
132ILK0.22399571
133NEK90.22385672
134SYK0.21813806
135RPS6KA20.21478435
136PRKCA0.21137572
137BTK0.21072448
138EEF2K0.20195535
139IRAK10.20140839
140NEK60.19832712
141LYN0.19624634
142CSNK1A10.17774828
143CAMK2B0.17709661
144PIM20.17684501
145IKBKE0.17579327
146CAMK2A0.17335851
147CAMKK10.16851285

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.42706846
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.23241826
3Renin-angiotensin system_Homo sapiens_hsa046142.74411417
4Fat digestion and absorption_Homo sapiens_hsa049752.71303451
5Mineral absorption_Homo sapiens_hsa049782.58277063
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.49389540
7Caffeine metabolism_Homo sapiens_hsa002322.44287274
8Bile secretion_Homo sapiens_hsa049762.24750383
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.22135932
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18510484
11Nitrogen metabolism_Homo sapiens_hsa009102.12907439
12Protein digestion and absorption_Homo sapiens_hsa049742.04713634
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93858438
14Glutathione metabolism_Homo sapiens_hsa004801.93623941
15Linoleic acid metabolism_Homo sapiens_hsa005911.89819772
16Other glycan degradation_Homo sapiens_hsa005111.86650475
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78084537
18Starch and sucrose metabolism_Homo sapiens_hsa005001.76890553
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72015641
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64744768
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64541145
22Sulfur metabolism_Homo sapiens_hsa009201.62723905
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59965469
24PPAR signaling pathway_Homo sapiens_hsa033201.54912540
25Galactose metabolism_Homo sapiens_hsa000521.54639259
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43501529
27Tryptophan metabolism_Homo sapiens_hsa003801.42585569
28Fatty acid degradation_Homo sapiens_hsa000711.41750490
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41613722
30Histidine metabolism_Homo sapiens_hsa003401.36303775
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33081999
32Sphingolipid metabolism_Homo sapiens_hsa006001.32717120
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31801106
34Thyroid hormone synthesis_Homo sapiens_hsa049181.28678357
35Lysosome_Homo sapiens_hsa041421.26995239
36Butanoate metabolism_Homo sapiens_hsa006501.26921113
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26651103
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.24911361
39Arginine biosynthesis_Homo sapiens_hsa002201.23253673
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18743987
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13268404
42Pyruvate metabolism_Homo sapiens_hsa006201.13188668
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06225235
44Arginine and proline metabolism_Homo sapiens_hsa003301.04031978
45beta-Alanine metabolism_Homo sapiens_hsa004101.02658784
46Glycerolipid metabolism_Homo sapiens_hsa005611.02063932
47Folate biosynthesis_Homo sapiens_hsa007901.00090812
48Rheumatoid arthritis_Homo sapiens_hsa053230.98661689
49Peroxisome_Homo sapiens_hsa041460.98140657
50ECM-receptor interaction_Homo sapiens_hsa045120.96959550
51Phenylalanine metabolism_Homo sapiens_hsa003600.96700923
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95305427
53Amoebiasis_Homo sapiens_hsa051460.91586642
54Propanoate metabolism_Homo sapiens_hsa006400.90833963
55Fructose and mannose metabolism_Homo sapiens_hsa000510.90742477
56Collecting duct acid secretion_Homo sapiens_hsa049660.90402570
57Pentose phosphate pathway_Homo sapiens_hsa000300.89569841
58Ether lipid metabolism_Homo sapiens_hsa005650.87460892
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.87155383
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86554678
61Carbon metabolism_Homo sapiens_hsa012000.84525189
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79791968
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76829027
64Arachidonic acid metabolism_Homo sapiens_hsa005900.74893004
65Complement and coagulation cascades_Homo sapiens_hsa046100.74110983
66Fatty acid metabolism_Homo sapiens_hsa012120.72517978
67Gastric acid secretion_Homo sapiens_hsa049710.72305077
68Lysine degradation_Homo sapiens_hsa003100.71837057
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70681685
70Retinol metabolism_Homo sapiens_hsa008300.69439525
71Sulfur relay system_Homo sapiens_hsa041220.66947000
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65873905
73Pancreatic secretion_Homo sapiens_hsa049720.65552938
74Tuberculosis_Homo sapiens_hsa051520.63960168
75Asthma_Homo sapiens_hsa053100.63825818
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.63312229
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.62139228
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60788685
79ABC transporters_Homo sapiens_hsa020100.60449888
80Leishmaniasis_Homo sapiens_hsa051400.57992651
81Focal adhesion_Homo sapiens_hsa045100.57012910
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54789298
83TGF-beta signaling pathway_Homo sapiens_hsa043500.53536910
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51871925
85Staphylococcus aureus infection_Homo sapiens_hsa051500.51764357
86Hematopoietic cell lineage_Homo sapiens_hsa046400.51159600
87Dilated cardiomyopathy_Homo sapiens_hsa054140.50262220
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50186446
89Tyrosine metabolism_Homo sapiens_hsa003500.49615567
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47654327
91Chemical carcinogenesis_Homo sapiens_hsa052040.47193767
92Biosynthesis of amino acids_Homo sapiens_hsa012300.45128715
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.45083581
94Osteoclast differentiation_Homo sapiens_hsa043800.43288797
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.41496950
96Salmonella infection_Homo sapiens_hsa051320.41266057
97Allograft rejection_Homo sapiens_hsa053300.40385329
98Pertussis_Homo sapiens_hsa051330.40374162
99Proteoglycans in cancer_Homo sapiens_hsa052050.40204538
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38222253
101Pancreatic cancer_Homo sapiens_hsa052120.38025741
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37726378
103Vibrio cholerae infection_Homo sapiens_hsa051100.37396519
104Tight junction_Homo sapiens_hsa045300.37316818
105Autoimmune thyroid disease_Homo sapiens_hsa053200.36488423
106Insulin resistance_Homo sapiens_hsa049310.34645663
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.34065458
108Steroid biosynthesis_Homo sapiens_hsa001000.33885176
109Graft-versus-host disease_Homo sapiens_hsa053320.33480315
110Toxoplasmosis_Homo sapiens_hsa051450.33445954
111Fatty acid biosynthesis_Homo sapiens_hsa000610.33322406
112Chronic myeloid leukemia_Homo sapiens_hsa052200.31769654
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.31649160
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28650414
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27172549
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.26807909
117Renin secretion_Homo sapiens_hsa049240.26102191
118Cocaine addiction_Homo sapiens_hsa050300.24316379
119Metabolic pathways_Homo sapiens_hsa011000.23973387
120Hepatitis C_Homo sapiens_hsa051600.19200918
121Type I diabetes mellitus_Homo sapiens_hsa049400.19125534
122Glucagon signaling pathway_Homo sapiens_hsa049220.16774157
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14421049
124Insulin secretion_Homo sapiens_hsa049110.13005601
125Serotonergic synapse_Homo sapiens_hsa047260.10448239
126Amphetamine addiction_Homo sapiens_hsa050310.08555080
127Ovarian steroidogenesis_Homo sapiens_hsa049130.04332452
128AMPK signaling pathway_Homo sapiens_hsa041520.03936522
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03674502
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03534337
131Antigen processing and presentation_Homo sapiens_hsa046120.02027407
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01355628
133GnRH signaling pathway_Homo sapiens_hsa049120.00899359

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