GUCY1B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)9.06521608
2keratinocyte development (GO:0003334)7.28753839
3neurotransmitter catabolic process (GO:0042135)6.31431453
4microtubule depolymerization (GO:0007019)6.30211424
5cerebral cortex radially oriented cell migration (GO:0021799)5.87117390
6axon ensheathment in central nervous system (GO:0032291)5.85028129
7central nervous system myelination (GO:0022010)5.85028129
8microtubule polymerization or depolymerization (GO:0031109)5.24347444
9limb bud formation (GO:0060174)5.10910148
10sensory perception of chemical stimulus (GO:0007606)4.75116060
11gonadal mesoderm development (GO:0007506)4.71454954
12maturation of SSU-rRNA (GO:0030490)4.66504907
13mitotic metaphase plate congression (GO:0007080)4.63042996
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.61861806
15substrate-independent telencephalic tangential migration (GO:0021826)4.61861806
16lateral sprouting from an epithelium (GO:0060601)4.60263105
17forebrain neuron differentiation (GO:0021879)4.35385078
18cell wall macromolecule catabolic process (GO:0016998)4.33669169
19lung-associated mesenchyme development (GO:0060484)4.26934256
20cell wall macromolecule metabolic process (GO:0044036)4.16790688
21histone H2B ubiquitination (GO:0033523)4.05289490
22cell migration in hindbrain (GO:0021535)3.95201025
23midgut development (GO:0007494)3.92379970
24oligodendrocyte development (GO:0014003)3.88846239
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87180536
26pyrimidine nucleobase catabolic process (GO:0006208)3.79499122
27oligodendrocyte differentiation (GO:0048709)3.76082209
28regulation of cellular amino acid metabolic process (GO:0006521)3.75131036
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74426098
30centriole replication (GO:0007099)3.71602378
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68795279
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68795279
33DNA integration (GO:0015074)3.67432412
34DNA deamination (GO:0045006)3.66209975
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.65984422
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.62779822
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.62466084
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.62466084
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.62466084
40negative regulation of astrocyte differentiation (GO:0048712)3.62158981
41lens fiber cell development (GO:0070307)3.56941437
42negative regulation of axon extension (GO:0030517)3.55051782
43negative regulation of RNA splicing (GO:0033119)3.54801352
44neural tube formation (GO:0001841)3.53506189
45cholesterol biosynthetic process (GO:0006695)3.53471101
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.51710004
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.51710004
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.51167755
49meiotic chromosome segregation (GO:0045132)3.48623617
50DNA ligation (GO:0006266)3.46957407
51DNA replication-dependent nucleosome assembly (GO:0006335)3.45873246
52DNA replication-dependent nucleosome organization (GO:0034723)3.45873246
53protein depolymerization (GO:0051261)3.45567820
54protein heterotetramerization (GO:0051290)3.43902297
55cerebral cortex cell migration (GO:0021795)3.41166360
56regulation of meiosis I (GO:0060631)3.38700050
57viral protein processing (GO:0019082)3.37891511
58peptidyl-histidine modification (GO:0018202)3.35321188
59myelin maintenance (GO:0043217)3.33322550
60proteasome assembly (GO:0043248)3.32933090
61RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31643703
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31643703
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31091835
64auditory receptor cell differentiation (GO:0042491)3.30739240
65hepatocyte apoptotic process (GO:0097284)3.30371248
66myelination (GO:0042552)3.26441835
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24394617
68centriole assembly (GO:0098534)3.23577604
69protein insertion into membrane (GO:0051205)3.21158932
70negative regulation of axon guidance (GO:1902668)3.20941988
71ATP synthesis coupled proton transport (GO:0015986)3.18407276
72energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18407276
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.17806748
74negative regulation of ligase activity (GO:0051352)3.17806748
75forebrain cell migration (GO:0021885)3.16906640
76ribosomal small subunit assembly (GO:0000028)3.16404332
77cell proliferation in forebrain (GO:0021846)3.16083392
78ensheathment of neurons (GO:0007272)3.15331696
79axon ensheathment (GO:0008366)3.15331696
80piRNA metabolic process (GO:0034587)3.14152414
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12240467
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12115395
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09037291
84forebrain neuron development (GO:0021884)3.05636639
85telencephalon cell migration (GO:0022029)3.04495623
86branching involved in labyrinthine layer morphogenesis (GO:0060670)3.04453047
87metaphase plate congression (GO:0051310)3.03815543
88DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.02079872
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99688896
90base-excision repair, AP site formation (GO:0006285)2.97908292
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97240934
92glial cell development (GO:0021782)2.96834910
93establishment of integrated proviral latency (GO:0075713)2.96707860
94ganglion development (GO:0061548)2.96645777
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94881888
96negative regulation of axonogenesis (GO:0050771)2.93573006
97establishment of mitochondrion localization (GO:0051654)2.92883316
98negative regulation of microtubule polymerization (GO:0031115)2.92479452
99positive regulation of ligase activity (GO:0051351)2.92407355
100positive regulation of neuroblast proliferation (GO:0002052)2.92312468
101ether lipid metabolic process (GO:0046485)2.91677171
102negative regulation of transcription regulatory region DNA binding (GO:2000678)2.91457055
103mannosylation (GO:0097502)2.88236195
104glycerol ether metabolic process (GO:0006662)2.86958182
105intraciliary transport (GO:0042073)2.86665746
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.86661029
107termination of RNA polymerase III transcription (GO:0006386)2.86661029
108DNA double-strand break processing (GO:0000729)2.86453570
109neuron cell-cell adhesion (GO:0007158)2.86420643
110regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85859502
111lactate metabolic process (GO:0006089)2.85347720
112neuronal stem cell maintenance (GO:0097150)2.82414189
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82306522
114cerebral cortex neuron differentiation (GO:0021895)2.81740043
115non-recombinational repair (GO:0000726)2.81089419
116double-strand break repair via nonhomologous end joining (GO:0006303)2.81089419
117regulation of centriole replication (GO:0046599)2.79280449
118regulation of cellular amine metabolic process (GO:0033238)2.79005763
119negative regulation of mRNA processing (GO:0050686)2.77397542
120substantia nigra development (GO:0021762)2.77267978
121sterol biosynthetic process (GO:0016126)2.75522744
122negative regulation of gliogenesis (GO:0014014)2.75175738
123positive regulation of translational initiation (GO:0045948)2.74619861
124replication fork processing (GO:0031297)2.73902945
125regulation of activation of Janus kinase activity (GO:0010533)2.73896719
126nucleobase catabolic process (GO:0046113)2.73683755
127intestinal epithelial cell development (GO:0060576)2.72864514
128negative regulation of T cell differentiation in thymus (GO:0033085)2.72676512
129cell fate commitment involved in formation of primary germ layer (GO:0060795)2.72136853
130presynaptic membrane assembly (GO:0097105)2.71728073
131positive regulation of cell cycle arrest (GO:0071158)2.71474138
132positive regulation of meiosis (GO:0045836)2.70602748
133L-methionine salvage (GO:0071267)2.69779429
134L-methionine biosynthetic process (GO:0071265)2.69779429
135amino acid salvage (GO:0043102)2.69779429
136positive regulation of meiotic cell cycle (GO:0051446)2.69221197
137mitochondrion transport along microtubule (GO:0047497)2.68836393
138establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68836393
139dendrite morphogenesis (GO:0048813)2.68595042
140neuron recognition (GO:0008038)2.68462516
141behavioral response to nicotine (GO:0035095)2.68136006
142sympathetic nervous system development (GO:0048485)2.67647954
143negative regulation of JUN kinase activity (GO:0043508)2.67415605
144respiratory chain complex IV assembly (GO:0008535)2.66714551
145cranial nerve morphogenesis (GO:0021602)2.66272504
146negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.64683526
147regulation of keratinocyte proliferation (GO:0010837)2.63118797
148mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63007461
149myoblast migration (GO:0051451)2.62831518
150ether metabolic process (GO:0018904)2.62604605
151kidney morphogenesis (GO:0060993)2.62093149
152rRNA catabolic process (GO:0016075)2.61747622
153translational termination (GO:0006415)2.61458714
154signal transduction in response to DNA damage (GO:0042770)2.61383950
155ganglioside metabolic process (GO:0001573)2.61019466
156axonal fasciculation (GO:0007413)2.60179389
157negative regulation of complement activation (GO:0045916)2.59324593
158cotranslational protein targeting to membrane (GO:0006613)2.59292897
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.59288231
160negative regulation of glial cell differentiation (GO:0045686)2.58891870
161inner ear receptor cell differentiation (GO:0060113)2.58748134
162glandular epithelial cell differentiation (GO:0002067)2.58385659
163neuroepithelial cell differentiation (GO:0060563)2.58248507
164V(D)J recombination (GO:0033151)2.57419173
165regulation of astrocyte differentiation (GO:0048710)2.56821006
166GTP biosynthetic process (GO:0006183)2.56269674
167embryonic epithelial tube formation (GO:0001838)2.55657934
168electron transport chain (GO:0022900)2.55370121
169protein localization to cilium (GO:0061512)2.55046109
170actin filament depolymerization (GO:0030042)2.54971327
171protein targeting to ER (GO:0045047)2.53723971
172central nervous system neuron development (GO:0021954)2.53538468
173viral transcription (GO:0019083)2.53256266
174respiratory electron transport chain (GO:0022904)2.52527934
175fusion of sperm to egg plasma membrane (GO:0007342)2.52111374
176regulation of ubiquitin-protein transferase activity (GO:0051438)2.52011031
177respiratory tube development (GO:0030323)2.51157718
178rRNA modification (GO:0000154)2.50225083
179cardiac right ventricle morphogenesis (GO:0003215)2.50003494
180metanephric nephron tubule development (GO:0072234)2.49455515
181regulation of ligase activity (GO:0051340)2.48046256
182aldehyde catabolic process (GO:0046185)2.43850479
183translation (GO:0006412)2.43758313
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.43460820
185regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43246035
186regulation of mitotic spindle checkpoint (GO:1903504)2.43246035
187negative regulation of translational initiation (GO:0045947)2.42873222
188translational elongation (GO:0006414)2.42576844
189RNA localization (GO:0006403)2.42088853
190proline biosynthetic process (GO:0006561)2.40969192
191UTP biosynthetic process (GO:0006228)2.40817330
192nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40233427
193establishment of protein localization to endoplasmic reticulum (GO:0072599)2.40128811
194UTP metabolic process (GO:0046051)2.39003707
195nuclear pore complex assembly (GO:0051292)2.38145554

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.13313796
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21872343
3AR_21572438_ChIP-Seq_LNCaP_Human3.94030850
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.86908744
5GATA1_26923725_Chip-Seq_HPCs_Mouse3.37583964
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37162483
7ESR1_15608294_ChIP-ChIP_MCF-7_Human3.19130391
8EZH2_22144423_ChIP-Seq_EOC_Human3.13450581
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.10606320
10EZH2_27304074_Chip-Seq_ESCs_Mouse3.08502633
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.89470302
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80984415
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79753461
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74581103
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74581103
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67111428
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.66282889
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60194707
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59710636
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52706641
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.51014157
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46985599
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44945252
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.41853661
25ELK1_19687146_ChIP-ChIP_HELA_Human2.35745550
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.34494755
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.33736822
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.32009877
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27638945
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.25493781
31DROSHA_22980978_ChIP-Seq_HELA_Human2.19966421
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16026445
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13720117
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12692023
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.10994233
36VDR_23849224_ChIP-Seq_CD4+_Human2.09028367
37ERG_21242973_ChIP-ChIP_JURKAT_Human2.08934799
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.04808895
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.02374369
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.02241263
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01707555
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.01707555
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00373037
44* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98116958
45GBX2_23144817_ChIP-Seq_PC3_Human1.97370180
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.97055407
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95756035
48ELF5_23300383_ChIP-Seq_T47D_Human1.94885988
49RNF2_27304074_Chip-Seq_NSC_Mouse1.88638487
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88146397
51ER_23166858_ChIP-Seq_MCF-7_Human1.87329716
52FOXP3_21729870_ChIP-Seq_TREG_Human1.85303539
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85101692
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82490640
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.81936281
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81743204
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.78122654
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76987379
59TTF2_22483619_ChIP-Seq_HELA_Human1.74573206
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74493853
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74374187
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73323225
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72296015
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.70088395
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69503324
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69296505
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68919338
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67795356
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.67572100
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65839632
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.64976774
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64311676
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63200292
74GABP_19822575_ChIP-Seq_HepG2_Human1.62263147
75DCP1A_22483619_ChIP-Seq_HELA_Human1.61196142
76MYC_18940864_ChIP-ChIP_HL60_Human1.60746361
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60570097
78KDM5A_27292631_Chip-Seq_BREAST_Human1.58904862
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57155815
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56734265
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54362162
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51359342
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49320841
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47573139
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.47100288
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43465331
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42762686
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40561228
89AHR_22903824_ChIP-Seq_MCF-7_Human1.39593800
90AR_20517297_ChIP-Seq_VCAP_Human1.39142306
91E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38173809
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35199047
93XRN2_22483619_ChIP-Seq_HELA_Human1.33881630
94EWS_26573619_Chip-Seq_HEK293_Human1.31231668
95TBL1_22424771_ChIP-Seq_293T_Human1.29424131
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27116102
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26316409
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.25325875
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24083178
100TP53_22573176_ChIP-Seq_HFKS_Human1.23531193
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23320692
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23017757
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.22972387
104CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20999389
105AR_21909140_ChIP-Seq_LNCAP_Human1.20351455
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19165285
107HOXB7_26014856_ChIP-Seq_BT474_Human1.18468167
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17647778
109FUS_26573619_Chip-Seq_HEK293_Human1.17380603
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.16088249
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14781223
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14736046
113SOX17_20123909_ChIP-Seq_XEN_Mouse1.14558843
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12375085
115AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11865305
116NCOR_22424771_ChIP-Seq_293T_Human1.11824457
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11647861
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10838018
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10505716
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09793344
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09160213
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.08550759
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07693706
124* REST_18959480_ChIP-ChIP_MESCs_Mouse1.07295063
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06049855
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04905152
127* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04385376
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04052969
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03989866
130* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03489481
131* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03489481
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02433550
133SOX2_16153702_ChIP-ChIP_HESCs_Human1.01935857
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01506303
135CBP_20019798_ChIP-Seq_JUKART_Human0.98280001
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98280001
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97713422
138ZNF274_21170338_ChIP-Seq_K562_Hela0.97672292
139TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95749170
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.94948904
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.94748733
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93004859
143ERG_20517297_ChIP-Seq_VCAP_Human0.91699547
144VDR_22108803_ChIP-Seq_LS180_Human0.91446546
145* SOX9_26525672_Chip-Seq_HEART_Mouse0.91279262
146NANOG_16153702_ChIP-ChIP_HESCs_Human0.90876549
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90703620
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90140768
149EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89975026
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89769066
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89729250
152KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89642733
153KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89642733
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89642733
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89518326
156POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88464494
157NFYB_21822215_ChIP-Seq_K562_Human0.88273721
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.87858898
159NFYA_21822215_ChIP-Seq_K562_Human0.87642357
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87459628
161P300_19829295_ChIP-Seq_ESCs_Human0.87362925
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87227380
163TAF15_26573619_Chip-Seq_HEK293_Human0.87202485
164PHF8_20622853_ChIP-Seq_HELA_Human0.87029202
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.86575921
166GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85674322
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85493930
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85112383
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84000135
170CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83772301
171ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83652359
172BCAT_22108803_ChIP-Seq_LS180_Human0.83471116
173TCF4_22108803_ChIP-Seq_LS180_Human0.83081162
174EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82924673
175CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82384657
176* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82351012
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82239626
178KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81719119
179PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79679104
180KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79625503
181E2F7_22180533_ChIP-Seq_HELA_Human0.76663537
182CBX2_22325352_ChIP-Seq_293T-Rex_Human0.75751070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.55627482
2MP0003136_yellow_coat_color5.57673864
3MP0001984_abnormal_olfaction4.73410583
4MP0002653_abnormal_ependyma_morphology4.68128226
5MP0003787_abnormal_imprinting3.83743416
6MP0001485_abnormal_pinna_reflex3.08324017
7MP0000778_abnormal_nervous_system2.98843213
8MP0008995_early_reproductive_senescence2.92333979
9MP0000537_abnormal_urethra_morphology2.83459357
10MP0008877_abnormal_DNA_methylation2.74741012
11MP0004859_abnormal_synaptic_plasticity2.61618585
12MP0004264_abnormal_extraembryonic_tissu2.52663565
13MP0003880_abnormal_central_pattern2.39454619
14MP0005171_absent_coat_pigmentation2.30880377
15MP0003938_abnormal_ear_development2.22359328
16MP0005075_abnormal_melanosome_morpholog2.19351980
17MP0004957_abnormal_blastocyst_morpholog2.15551501
18MP0000579_abnormal_nail_morphology2.12759887
19MP0005367_renal/urinary_system_phenotyp2.09804085
20MP0000516_abnormal_urinary_system2.09804085
21MP0005187_abnormal_penis_morphology2.05485386
22MP0010094_abnormal_chromosome_stability2.03549641
23MP0001346_abnormal_lacrimal_gland2.02947965
24MP0004147_increased_porphyrin_level2.02544014
25MP0008058_abnormal_DNA_repair1.95170912
26MP0003941_abnormal_skin_development1.94273166
27MP0002277_abnormal_respiratory_mucosa1.88697073
28MP0003121_genomic_imprinting1.86988231
29MP0004272_abnormal_basement_membrane1.80144372
30MP0000920_abnormal_myelination1.79904215
31MP0002254_reproductive_system_inflammat1.77955879
32MP0006072_abnormal_retinal_apoptosis1.74315609
33MP0003718_maternal_effect1.73169054
34MP0000647_abnormal_sebaceous_gland1.71149305
35MP0002938_white_spotting1.70729128
36MP0000569_abnormal_digit_pigmentation1.67822153
37MP0005423_abnormal_somatic_nervous1.67447634
38MP0000372_irregular_coat_pigmentation1.65792642
39MP0004381_abnormal_hair_follicle1.65100185
40MP0003632_abnormal_nervous_system1.63759497
41MP0002184_abnormal_innervation1.62136653
42MP0005174_abnormal_tail_pigmentation1.61184027
43MP0002837_dystrophic_cardiac_calcinosis1.59604137
44MP0004270_analgesia1.55293829
45MP0000371_diluted_coat_color1.52495821
46MP0005623_abnormal_meninges_morphology1.52245082
47MP0009379_abnormal_foot_pigmentation1.50677575
48MP0000026_abnormal_inner_ear1.50357481
49MP0010030_abnormal_orbit_morphology1.49827358
50MP0000613_abnormal_salivary_gland1.49743533
51MP0003315_abnormal_perineum_morphology1.47300225
52MP0002295_abnormal_pulmonary_circulatio1.46986143
53MP0003890_abnormal_embryonic-extraembry1.43999635
54MP0000427_abnormal_hair_cycle1.43605807
55MP0002282_abnormal_trachea_morphology1.42620292
56MP0005083_abnormal_biliary_tract1.41770973
57MP0005408_hypopigmentation1.37852430
58MP0001929_abnormal_gametogenesis1.37696274
59MP0002064_seizures1.36700631
60MP0002822_catalepsy1.35597994
61MP0004742_abnormal_vestibular_system1.34263855
62MP0005410_abnormal_fertilization1.33763904
63MP0006292_abnormal_olfactory_placode1.33673013
64MP0008789_abnormal_olfactory_epithelium1.33513756
65MP0003634_abnormal_glial_cell1.32419517
66MP0002210_abnormal_sex_determination1.31631996
67MP0002882_abnormal_neuron_morphology1.31231323
68MP0002876_abnormal_thyroid_physiology1.30790929
69MP0005646_abnormal_pituitary_gland1.30335555
70MP0008875_abnormal_xenobiotic_pharmacok1.30163386
71MP0003635_abnormal_synaptic_transmissio1.29980285
72MP0003123_paternal_imprinting1.29600154
73MP0004811_abnormal_neuron_physiology1.28660357
74MP0003936_abnormal_reproductive_system1.27252033
75MP0001486_abnormal_startle_reflex1.26201358
76MP0002752_abnormal_somatic_nervous1.25411849
77MP0002234_abnormal_pharynx_morphology1.24911247
78MP0003693_abnormal_embryo_hatching1.24663911
79MP0001324_abnormal_eye_pigmentation1.24002257
80MP0002272_abnormal_nervous_system1.23993439
81MP0005377_hearing/vestibular/ear_phenot1.22070306
82MP0003878_abnormal_ear_physiology1.22070306
83MP0002095_abnormal_skin_pigmentation1.20554721
84MP0001145_abnormal_male_reproductive1.18804503
85MP0001919_abnormal_reproductive_system1.18490145
86MP0003698_abnormal_male_reproductive1.18125164
87MP0002796_impaired_skin_barrier1.15258999
88MP0005394_taste/olfaction_phenotype1.15131675
89MP0005499_abnormal_olfactory_system1.15131675
90MP0008932_abnormal_embryonic_tissue1.14553367
91MP0002229_neurodegeneration1.13152765
92MP0003861_abnormal_nervous_system1.11774199
93MP0005645_abnormal_hypothalamus_physiol1.09973019
94MP0002098_abnormal_vibrissa_morphology1.09909780
95MP0000653_abnormal_sex_gland1.08986226
96MP0003942_abnormal_urinary_system1.08908159
97MP0000631_abnormal_neuroendocrine_gland1.07804264
98MP0002152_abnormal_brain_morphology1.07412371
99MP0004782_abnormal_surfactant_physiolog1.06901055
100MP0002249_abnormal_larynx_morphology1.06176614
101MP0001915_intracranial_hemorrhage1.06074163
102MP0009053_abnormal_anal_canal1.05618178
103MP0002751_abnormal_autonomic_nervous1.05443728
104MP0000534_abnormal_ureter_morphology1.05048033
105MP0008872_abnormal_physiological_respon1.04042620
106MP0003786_premature_aging1.02864733
107MP0003077_abnormal_cell_cycle1.02470769
108MP0002177_abnormal_outer_ear1.00467438
109MP0000627_abnormal_mammary_gland1.00009747
110MP0004233_abnormal_muscle_weight0.99987787
111MP0001968_abnormal_touch/_nociception0.96853554
112MP0003385_abnormal_body_wall0.95661684
113MP0005389_reproductive_system_phenotype0.95163597
114MP0001666_abnormal_nutrient_absorption0.94957447
115MP0001881_abnormal_mammary_gland0.94589763
116MP0001529_abnormal_vocalization0.94185626
117MP0003943_abnormal_hepatobiliary_system0.93733632
118MP0002735_abnormal_chemical_nociception0.92765719
119MP0002063_abnormal_learning/memory/cond0.92595024
120MP0000955_abnormal_spinal_cord0.90965250
121MP0004885_abnormal_endolymph0.90586911
122MP0001727_abnormal_embryo_implantation0.90405034
123MP0005248_abnormal_Harderian_gland0.89656493
124MP0000538_abnormal_urinary_bladder0.88826892
125MP0005551_abnormal_eye_electrophysiolog0.88380967
126MP0005253_abnormal_eye_physiology0.88253827
127MP0010386_abnormal_urinary_bladder0.88112883
128MP0003252_abnormal_bile_duct0.87546680
129MP0003806_abnormal_nucleotide_metabolis0.87046099
130MP0001963_abnormal_hearing_physiology0.86908283
131MP0005386_behavior/neurological_phenoty0.84856779
132MP0004924_abnormal_behavior0.84856779
133MP0003879_abnormal_hair_cell0.84013431
134MP0004133_heterotaxia0.83830279
135MP0000465_gastrointestinal_hemorrhage0.83120087
136MP0002161_abnormal_fertility/fecundity0.82457070
137MP0000383_abnormal_hair_follicle0.82406553
138MP0000681_abnormal_thyroid_gland0.82333918
139MP0000428_abnormal_craniofacial_morphol0.81442994
140MP0001286_abnormal_eye_development0.80806826
141MP0005195_abnormal_posterior_eye0.80786645
142MP0002066_abnormal_motor_capabilities/c0.80121168
143MP0009046_muscle_twitch0.79553722
144MP0003937_abnormal_limbs/digits/tail_de0.79552515
145MP0009745_abnormal_behavioral_response0.79207006
146MP0006035_abnormal_mitochondrial_morpho0.78934969
147MP0000678_abnormal_parathyroid_gland0.78701809
148MP0000015_abnormal_ear_pigmentation0.77843936
149MP0003755_abnormal_palate_morphology0.77135854
150MP0002163_abnormal_gland_morphology0.77085414
151MP0006036_abnormal_mitochondrial_physio0.76448822
152MP0002111_abnormal_tail_morphology0.75968460
153MP0002557_abnormal_social/conspecific_i0.75865835
154MP0002009_preneoplasia0.75400059
155MP0006276_abnormal_autonomic_nervous0.74455505
156MP0005076_abnormal_cell_differentiation0.73200868
157MP0001177_atelectasis0.72030551
158MP0002572_abnormal_emotion/affect_behav0.71244632
159MP0002081_perinatal_lethality0.69715973
160MP0001293_anophthalmia0.69254459
161MP0000049_abnormal_middle_ear0.69124343
162MP0002233_abnormal_nose_morphology0.67757121
163MP0002160_abnormal_reproductive_system0.67219056
164MP0000462_abnormal_digestive_system0.66169936
165MP0010678_abnormal_skin_adnexa0.65173616
166MP0005395_other_phenotype0.65125710
167MP0002067_abnormal_sensory_capabilities0.64827644
168MP0004142_abnormal_muscle_tone0.64660843
169MP0008057_abnormal_DNA_replication0.62985365
170MP0002082_postnatal_lethality0.61530326
171MP0010770_preweaning_lethality0.61530326

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.48847594
2Ependymoma (HP:0002888)5.37660245
3Cerebral hypomyelination (HP:0006808)5.11930433
4Abnormality of the astrocytes (HP:0100707)4.39688506
5Astrocytoma (HP:0009592)4.39688506
6Stenosis of the external auditory canal (HP:0000402)4.11844810
7Retinal dysplasia (HP:0007973)3.84096995
8Glioma (HP:0009733)3.66205661
9Type I transferrin isoform profile (HP:0003642)3.62225270
10Esophageal atresia (HP:0002032)3.62218099
11Split foot (HP:0001839)3.57909606
12Intellectual disability, moderate (HP:0002342)3.51399201
13Alacrima (HP:0000522)3.48194721
14Hypochromic microcytic anemia (HP:0004840)3.36523287
15Abnormal respiratory motile cilium physiology (HP:0012261)3.34413564
16Conical tooth (HP:0000698)3.32533949
17Termporal pattern (HP:0011008)3.28239022
18Insidious onset (HP:0003587)3.28239022
19Coronal craniosynostosis (HP:0004440)3.27931456
20Megalencephaly (HP:0001355)3.23830867
21Abnormality of placental membranes (HP:0011409)3.10863585
22Amniotic constriction ring (HP:0009775)3.10863585
23Absent septum pellucidum (HP:0001331)3.06265341
24Abnormality of the septum pellucidum (HP:0007375)3.03327959
25Pancreatic fibrosis (HP:0100732)3.00210479
26Tubulointerstitial nephritis (HP:0001970)2.98043511
27Chronic hepatic failure (HP:0100626)2.97546748
28Chromsome breakage (HP:0040012)2.96420362
29Pancreatic cysts (HP:0001737)2.94103952
303-Methylglutaconic aciduria (HP:0003535)2.93040913
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88829290
32Congenital stationary night blindness (HP:0007642)2.86260708
33Acute necrotizing encephalopathy (HP:0006965)2.82108862
34Anteriorly placed anus (HP:0001545)2.79502095
35Septate vagina (HP:0001153)2.78487760
36Dysphonia (HP:0001618)2.76582902
37Hypoplastic nipples (HP:0002557)2.76037533
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.72939358
39Decreased lacrimation (HP:0000633)2.71343734
40Cystic liver disease (HP:0006706)2.70573681
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70464096
42Limb dystonia (HP:0002451)2.69495500
43Bony spicule pigmentary retinopathy (HP:0007737)2.67885442
44Abnormal ciliary motility (HP:0012262)2.67321573
45Abnormality of the diencephalon (HP:0010662)2.67314265
46Degeneration of anterior horn cells (HP:0002398)2.66482166
47Abnormality of the anterior horn cell (HP:0006802)2.66482166
48Abnormality of the labia minora (HP:0012880)2.66371462
49Abnormal respiratory epithelium morphology (HP:0012253)2.65870823
50Abnormal respiratory motile cilium morphology (HP:0005938)2.65870823
51Bile duct proliferation (HP:0001408)2.62834750
52Abnormal biliary tract physiology (HP:0012439)2.62834750
53Abnormal protein N-linked glycosylation (HP:0012347)2.62189791
54Abnormal protein glycosylation (HP:0012346)2.62189791
55Abnormal glycosylation (HP:0012345)2.62189791
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.62189791
57Rhinitis (HP:0012384)2.61283780
58Bell-shaped thorax (HP:0001591)2.59175955
59Xerostomia (HP:0000217)2.58605551
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.57974198
61Male pseudohermaphroditism (HP:0000037)2.57630238
62Volvulus (HP:0002580)2.55759316
63Anencephaly (HP:0002323)2.54857182
64Lip pit (HP:0100267)2.53939916
65Acute encephalopathy (HP:0006846)2.53306960
66Hepatocellular necrosis (HP:0001404)2.52903257
67Delusions (HP:0000746)2.51959494
68Hypoplasia of the pons (HP:0012110)2.42622169
69Abnormal mitochondria in muscle tissue (HP:0008316)2.41128325
70Dyschromatopsia (HP:0007641)2.39343278
71Spastic diplegia (HP:0001264)2.38106999
72Restlessness (HP:0000711)2.35870666
73Mitochondrial inheritance (HP:0001427)2.35757517
74Absent/shortened dynein arms (HP:0200106)2.34059356
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.34059356
76Abnormality of incisor morphology (HP:0011063)2.33685594
77Agitation (HP:0000713)2.30651117
78Increased CSF lactate (HP:0002490)2.30089465
79Molar tooth sign on MRI (HP:0002419)2.29987964
80Abnormality of midbrain morphology (HP:0002418)2.29987964
81Reticulocytopenia (HP:0001896)2.28433050
82Atonic seizures (HP:0010819)2.27941640
83Parakeratosis (HP:0001036)2.26861040
84Abnormal hemoglobin (HP:0011902)2.25602501
85Chronic bronchitis (HP:0004469)2.24216632
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.22281528
87Septo-optic dysplasia (HP:0100842)2.21997364
88Shallow orbits (HP:0000586)2.20550430
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.18823773
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18823773
91Abnormality of the parathyroid morphology (HP:0011766)2.18353556
92Sclerocornea (HP:0000647)2.18231737
93Limb hypertonia (HP:0002509)2.18161677
94Exotropia (HP:0000577)2.17733172
95Conjugated hyperbilirubinemia (HP:0002908)2.17420773
96Concave nail (HP:0001598)2.17403561
97Ventricular fibrillation (HP:0001663)2.17350509
98Fair hair (HP:0002286)2.17023862
99Abnormality of the corticospinal tract (HP:0002492)2.16742641
100Progressive macrocephaly (HP:0004481)2.16726805
101Abnormality of the preputium (HP:0100587)2.16598372
102Spinal muscular atrophy (HP:0007269)2.15915027
103Rib fusion (HP:0000902)2.15341696
104Abnormality of the intervertebral disk (HP:0005108)2.15219051
105Aplasia/Hypoplasia of the nipples (HP:0006709)2.12369803
106Posterior subcapsular cataract (HP:0007787)2.11871453
107Personality changes (HP:0000751)2.11557330
108Central scotoma (HP:0000603)2.10001511
109Premature skin wrinkling (HP:0100678)2.09980267
110Oculomotor apraxia (HP:0000657)2.09753089
111Anomalous pulmonary venous return (HP:0010772)2.09560194
112Cupped ear (HP:0000378)2.08160440
113Abnormal auditory evoked potentials (HP:0006958)2.07290652
114Medial flaring of the eyebrow (HP:0010747)2.06047261
115Abnormality of the dental root (HP:0006486)2.04425152
116Taurodontia (HP:0000679)2.04425152
117Abnormality of permanent molar morphology (HP:0011071)2.04425152
118Nephronophthisis (HP:0000090)2.03699744
119Abnormality of lateral ventricle (HP:0030047)2.03571820
120Hepatic necrosis (HP:0002605)2.03482298
121Congenital ichthyosiform erythroderma (HP:0007431)2.03306856
122Spontaneous abortion (HP:0005268)2.02678976
123Rhabdomyosarcoma (HP:0002859)2.02608618
124Abnormality of the pons (HP:0007361)2.00890893
125Reduced antithrombin III activity (HP:0001976)2.00869768
126Abnormality of chromosome stability (HP:0003220)1.99409261
127Abnormality of the antihelix (HP:0009738)1.98554181
128True hermaphroditism (HP:0010459)1.95712579
129Type II lissencephaly (HP:0007260)1.93699680
130Short philtrum (HP:0000322)1.92899790
131Attenuation of retinal blood vessels (HP:0007843)1.91775021
132Broad metatarsal (HP:0001783)1.91686224
133Ridged nail (HP:0001807)1.91604049
134Vaginal atresia (HP:0000148)1.91575710
135Genital tract atresia (HP:0001827)1.90659410
136Horizontal nystagmus (HP:0000666)1.90498998
137Nasolacrimal duct obstruction (HP:0000579)1.90473798
138Abnormality of the pulmonary veins (HP:0011718)1.88782724
139Patellar aplasia (HP:0006443)1.86015376
140Hyperglycinuria (HP:0003108)1.85346199
141Fragile nails (HP:0001808)1.85217758
142Abnormality of molar morphology (HP:0011070)1.84862861
143Abnormality of molar (HP:0011077)1.84862861
144Midline defect of the nose (HP:0004122)1.84613425
145Athetosis (HP:0002305)1.84539579
146Infantile muscular hypotonia (HP:0008947)1.84391409
147Apathy (HP:0000741)1.84182896
148Congenital primary aphakia (HP:0007707)1.84171842
149Broad distal phalanx of finger (HP:0009836)1.84100906
150Deep venous thrombosis (HP:0002625)1.83965233
151Seborrheic dermatitis (HP:0001051)1.83334213
152Oligodactyly (hands) (HP:0001180)1.81025398
153Diastasis recti (HP:0001540)1.80413568
154Generalized hypopigmentation of hair (HP:0011358)1.80306991
155Medulloblastoma (HP:0002885)1.80207299
156Hypoplastic pelvis (HP:0008839)1.78549752
157Hypoplasia of the iris (HP:0007676)1.77726252
158Breast hypoplasia (HP:0003187)1.77127265
159Pendular nystagmus (HP:0012043)1.77001752
160Meckel diverticulum (HP:0002245)1.75829810
161Shawl scrotum (HP:0000049)1.75811686
162Facial cleft (HP:0002006)1.75803249
163Spina bifida occulta (HP:0003298)1.75531382
164Abnormality of oral frenula (HP:0000190)1.75081249
165Atrophy/Degeneration involving motor neurons (HP:0007373)1.74953339
166Abnormality of salivation (HP:0100755)1.74882958
167Tented upper lip vermilion (HP:0010804)1.74722680
168Neoplasm of striated muscle (HP:0009728)1.74218786
169Aplasia involving bones of the extremities (HP:0009825)1.73986968
170Aplasia involving bones of the upper limbs (HP:0009823)1.73986968
171Aplasia of the phalanges of the hand (HP:0009802)1.73986968
172Peripheral hypomyelination (HP:0007182)1.73460740
173Abnormality of glycolysis (HP:0004366)1.73343276
174Cerebral edema (HP:0002181)1.72268053
175Gait imbalance (HP:0002141)1.71771583
176Microvesicular hepatic steatosis (HP:0001414)1.71413698
177Abnormality of the renal medulla (HP:0100957)1.70472433
178Increased serum lactate (HP:0002151)1.70441403
179Cleft eyelid (HP:0000625)1.69433954
180Cone-rod dystrophy (HP:0000548)1.68995174
181Hypoproteinemia (HP:0003075)1.67456772
182Genetic anticipation (HP:0003743)1.64634919
183Aplastic anemia (HP:0001915)1.64390597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.28523652
2STK393.97457395
3FGFR23.11984660
4BCR3.02045628
5BRSK22.87983993
6ERBB32.84657961
7VRK22.77329410
8TLK12.65200065
9LIMK12.63226349
10MKNK22.28867045
11MKNK12.18089404
12MARK12.12819702
13SIK32.05421936
14EIF2AK12.03507474
15WNK42.03348916
16TRIM281.99761821
17MST1R1.98514989
18VRK11.92070773
19CAMKK21.90083225
20TNIK1.89879501
21NME11.84646871
22CDK191.82213108
23PLK21.80697774
24MUSK1.77153368
25PAK31.73383195
26MAP4K21.69889484
27MAPK131.64449184
28OXSR11.64007177
29CDC71.62147279
30EPHA21.58976967
31PLK41.53368052
32SCYL21.53137052
33CSNK1G31.50747295
34ALK1.46945085
35CAMK2B1.46683291
36STK241.45674399
37PKN11.44703048
38SRPK11.39317387
39ICK1.37378313
40BRSK11.36820310
41PBK1.35577161
42MST41.32427969
43MATK1.31346699
44EPHA31.28814597
45CSNK1A1L1.28561414
46EEF2K1.26406308
47BMPR1B1.25956603
48CSNK1G11.24597513
49FRK1.23307104
50NEK61.20596660
51LRRK21.20196876
52BUB11.19660671
53IRAK21.18967564
54NTRK21.17300119
55CCNB11.14399889
56NUAK11.12156543
57TAF11.10901492
58EPHB21.10108861
59CAMK2D1.09320297
60SIK11.08288157
61MAPK151.06980061
62EPHB11.04969325
63ZAK1.04945536
64WEE11.04114207
65DYRK20.97878090
66PHKG10.95896445
67PHKG20.95896445
68STK38L0.95762517
69PRKCQ0.95437051
70IRAK30.94970651
71MAP3K120.93702404
72MARK30.92273643
73CSNK1G20.91740603
74UHMK10.90705272
75BRD40.88131324
76KDR0.87160897
77NME20.86899441
78CAMKK10.86524769
79ILK0.82674334
80ATR0.80072508
81GRK70.78258318
82PRKCI0.76547843
83ACVR1B0.76422162
84EIF2AK20.74981363
85RPS6KB20.74758123
86ROCK20.74069881
87PRPF4B0.73671518
88FER0.73104871
89AURKA0.72934495
90MINK10.72319005
91IRAK10.71061081
92CAMK2G0.70256622
93CHEK20.69665258
94CSNK1E0.69184448
95MAP3K130.68674829
96WNK10.68149052
97DAPK20.66750452
98TSSK60.64711105
99INSRR0.63351068
100PLK10.60619211
101TRIB30.60244817
102PIK3CA0.60138874
103TESK10.59447431
104CDK140.58837065
105CDK30.58074599
106ROCK10.57705024
107STK160.57408920
108NTRK30.57113560
109EIF2AK30.56733974
110TTK0.56285891
111RPS6KB10.56036441
112FGFR10.55982845
113ERBB20.53549429
114CDK70.53480725
115MAPKAPK30.53368428
116MAP3K140.52483952
117CASK0.52031588
118STK110.51916093
119CDK50.51252739
120ERBB40.51099532
121MET0.50240167
122ATM0.50179839
123CHEK10.50132012
124EPHA40.48700784
125TRPM70.48373250
126TESK20.48083746
127CDK10.47362297
128NEK10.44779411
129CSNK1A10.44441195
130MAPKAPK50.42582349
131CSNK1D0.41417308
132CDK11A0.40030660
133NEK20.39744273
134CSNK2A20.38658931
135CHUK0.38191812
136CDK80.38106834
137RPS6KA10.37882497
138AURKB0.37383164
139PRKACB0.37124956
140CDK20.36867288
141CDK150.36538194
142LMTK20.35985013
143PRKAA10.35536388
144PLK30.35373757
145PKN20.35313962
146RPS6KA40.34794391
147CDK180.34768972
148PRKD30.34710882
149ADRBK10.34486823
150STK100.33664122
151BMPR20.33662626
152MAPK80.32920443
153GRK10.32324836
154IKBKB0.31218773

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.75674667
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.33558665
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.15618929
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.78802532
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03316853
6Steroid biosynthesis_Homo sapiens_hsa001002.59773036
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49471820
8Homologous recombination_Homo sapiens_hsa034402.44727166
9DNA replication_Homo sapiens_hsa030302.35803827
10Fanconi anemia pathway_Homo sapiens_hsa034602.25447013
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23582652
12Caffeine metabolism_Homo sapiens_hsa002322.23403740
13Spliceosome_Homo sapiens_hsa030402.18817297
14Phototransduction_Homo sapiens_hsa047442.08662179
15Basal cell carcinoma_Homo sapiens_hsa052172.02061640
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01942418
17Fatty acid elongation_Homo sapiens_hsa000621.99415640
18Base excision repair_Homo sapiens_hsa034101.96129824
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91961994
20Mismatch repair_Homo sapiens_hsa034301.88074899
21RNA degradation_Homo sapiens_hsa030181.83383072
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77857112
23Butanoate metabolism_Homo sapiens_hsa006501.72481304
24Axon guidance_Homo sapiens_hsa043601.67643135
25Non-homologous end-joining_Homo sapiens_hsa034501.66971054
26Systemic lupus erythematosus_Homo sapiens_hsa053221.65907595
27Pyrimidine metabolism_Homo sapiens_hsa002401.64962848
28Notch signaling pathway_Homo sapiens_hsa043301.59231159
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52800034
30Melanogenesis_Homo sapiens_hsa049161.50302986
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38478623
32Sphingolipid metabolism_Homo sapiens_hsa006001.38032517
33Parkinsons disease_Homo sapiens_hsa050121.37302887
34Hippo signaling pathway_Homo sapiens_hsa043901.36716427
35N-Glycan biosynthesis_Homo sapiens_hsa005101.32195057
36GABAergic synapse_Homo sapiens_hsa047271.30931439
37Regulation of autophagy_Homo sapiens_hsa041401.25765023
38Alcoholism_Homo sapiens_hsa050341.23683670
39Propanoate metabolism_Homo sapiens_hsa006401.20154717
40Sulfur metabolism_Homo sapiens_hsa009201.17481582
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14548736
42Arginine and proline metabolism_Homo sapiens_hsa003301.13705329
43Morphine addiction_Homo sapiens_hsa050321.09567650
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.09237807
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09190984
46One carbon pool by folate_Homo sapiens_hsa006701.08910595
47Collecting duct acid secretion_Homo sapiens_hsa049661.08020891
48Protein export_Homo sapiens_hsa030601.06069882
49Glutamatergic synapse_Homo sapiens_hsa047241.05365638
50Oxidative phosphorylation_Homo sapiens_hsa001901.04369390
51Basal transcription factors_Homo sapiens_hsa030221.03073167
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02484276
53Tryptophan metabolism_Homo sapiens_hsa003801.00130355
54Ether lipid metabolism_Homo sapiens_hsa005650.98412532
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.95527694
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95257940
57Alzheimers disease_Homo sapiens_hsa050100.94599171
58p53 signaling pathway_Homo sapiens_hsa041150.91115057
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90813590
60Hedgehog signaling pathway_Homo sapiens_hsa043400.87398833
61Metabolic pathways_Homo sapiens_hsa011000.87315904
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86462092
63Proteasome_Homo sapiens_hsa030500.85949356
64Phenylalanine metabolism_Homo sapiens_hsa003600.84944481
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83634159
66Pyruvate metabolism_Homo sapiens_hsa006200.83100065
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.80611253
68ECM-receptor interaction_Homo sapiens_hsa045120.78439542
69RNA polymerase_Homo sapiens_hsa030200.76439868
70Circadian entrainment_Homo sapiens_hsa047130.75999248
71Peroxisome_Homo sapiens_hsa041460.75296478
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75011811
73Huntingtons disease_Homo sapiens_hsa050160.74177057
74Cholinergic synapse_Homo sapiens_hsa047250.73145387
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71453968
76Small cell lung cancer_Homo sapiens_hsa052220.70860176
77mRNA surveillance pathway_Homo sapiens_hsa030150.69487009
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68710978
79Taste transduction_Homo sapiens_hsa047420.68621604
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67676418
81Gastric acid secretion_Homo sapiens_hsa049710.67402050
82Ribosome_Homo sapiens_hsa030100.66869659
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66359072
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65529803
85Oocyte meiosis_Homo sapiens_hsa041140.64748054
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61461106
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58579831
88Glutathione metabolism_Homo sapiens_hsa004800.58096912
89Wnt signaling pathway_Homo sapiens_hsa043100.57939894
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57896946
91beta-Alanine metabolism_Homo sapiens_hsa004100.57532113
92Pentose phosphate pathway_Homo sapiens_hsa000300.55984044
93Gap junction_Homo sapiens_hsa045400.54425922
94Ovarian steroidogenesis_Homo sapiens_hsa049130.54135504
95Tight junction_Homo sapiens_hsa045300.52895349
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51816241
97cAMP signaling pathway_Homo sapiens_hsa040240.51760666
98Tyrosine metabolism_Homo sapiens_hsa003500.51195098
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51088325
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50583583
101Carbon metabolism_Homo sapiens_hsa012000.50160009
102Nitrogen metabolism_Homo sapiens_hsa009100.50097075
103Fatty acid metabolism_Homo sapiens_hsa012120.49455037
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48453487
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.48337018
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48084236
107Dilated cardiomyopathy_Homo sapiens_hsa054140.47016713
108Ras signaling pathway_Homo sapiens_hsa040140.46478095
109Linoleic acid metabolism_Homo sapiens_hsa005910.46271980
110Lysine degradation_Homo sapiens_hsa003100.46068751
111Serotonergic synapse_Homo sapiens_hsa047260.45743418
112Chemical carcinogenesis_Homo sapiens_hsa052040.45547841
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.45277378
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45240315
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44395779
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44289164
117Purine metabolism_Homo sapiens_hsa002300.44023970
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43793752
119Cell cycle_Homo sapiens_hsa041100.43328829
120Histidine metabolism_Homo sapiens_hsa003400.42303023
121Biosynthesis of amino acids_Homo sapiens_hsa012300.42235416
122Long-term depression_Homo sapiens_hsa047300.41407101
123Nucleotide excision repair_Homo sapiens_hsa034200.41247794
124ABC transporters_Homo sapiens_hsa020100.40928388
125Fatty acid degradation_Homo sapiens_hsa000710.40556151
126Chronic myeloid leukemia_Homo sapiens_hsa052200.38939809
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38101628
128Salivary secretion_Homo sapiens_hsa049700.37766771
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37617214
130Vitamin B6 metabolism_Homo sapiens_hsa007500.36676163
131Vibrio cholerae infection_Homo sapiens_hsa051100.36443638
132Starch and sucrose metabolism_Homo sapiens_hsa005000.36172141
133MicroRNAs in cancer_Homo sapiens_hsa052060.35421679
134Viral myocarditis_Homo sapiens_hsa054160.35243602
135Retinol metabolism_Homo sapiens_hsa008300.34537947
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34260522
137Type I diabetes mellitus_Homo sapiens_hsa049400.33760067
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31661479
139Oxytocin signaling pathway_Homo sapiens_hsa049210.30519632
140RNA transport_Homo sapiens_hsa030130.30385625
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30225186
142Cardiac muscle contraction_Homo sapiens_hsa042600.30161225
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30121625
144Dorso-ventral axis formation_Homo sapiens_hsa043200.30121515
145Dopaminergic synapse_Homo sapiens_hsa047280.29707297
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29654677
147Epstein-Barr virus infection_Homo sapiens_hsa051690.28473391
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28151144
149Insulin secretion_Homo sapiens_hsa049110.27706660
150TGF-beta signaling pathway_Homo sapiens_hsa043500.23924158
151Pancreatic cancer_Homo sapiens_hsa052120.22769023
152Complement and coagulation cascades_Homo sapiens_hsa046100.21852962
153Autoimmune thyroid disease_Homo sapiens_hsa053200.21811900
154HTLV-I infection_Homo sapiens_hsa051660.21586422
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.20235543

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »