GUCY2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that functions as a receptor for endogenous peptides guanylin and uroguanylin, and the heat-stable E. coli enterotoxin. The encoded protein activates the cystic fibrosis transmembrane conductance regulator. Mutations in this gene are associated with familial diarrhea (autosomal dominant) and meconium ileus (autosomal recessive). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)9.78273232
2angiotensin maturation (GO:0002003)8.07524976
3UDP-N-acetylglucosamine metabolic process (GO:0006047)7.40125387
4regulation of guanylate cyclase activity (GO:0031282)7.36658332
5epoxygenase P450 pathway (GO:0019373)6.27702038
6fat-soluble vitamin biosynthetic process (GO:0042362)5.83906984
7flavonoid metabolic process (GO:0009812)5.78280441
8intestinal epithelial cell development (GO:0060576)5.71893877
9regulation of bile acid biosynthetic process (GO:0070857)5.71729195
10purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.67587613
113-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.67587613
12digestive system process (GO:0022600)5.67207409
13positive regulation of guanylate cyclase activity (GO:0031284)5.54602176
14actin filament depolymerization (GO:0030042)5.45404607
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.39714208
16vitamin A metabolic process (GO:0006776)5.38831667
17regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.35303217
18maintenance of gastrointestinal epithelium (GO:0030277)5.22892097
19regulation of cellular extravasation (GO:0002691)4.98158741
20uronic acid metabolic process (GO:0006063)4.89719763
21glucuronate metabolic process (GO:0019585)4.89719763
22drug catabolic process (GO:0042737)4.83371193
23fructose metabolic process (GO:0006000)4.78213106
24regulation of systemic arterial blood pressure (GO:0003073)4.75482033
25bile acid and bile salt transport (GO:0015721)4.66346274
26response to hepatocyte growth factor (GO:0035728)4.54066736
27cellular response to hepatocyte growth factor stimulus (GO:0035729)4.54066736
28peptide hormone processing (GO:0016486)4.50905395
29renal system process involved in regulation of blood volume (GO:0001977)4.49527180
30regulation of cGMP biosynthetic process (GO:0030826)4.46749662
31phospholipid efflux (GO:0033700)4.38867775
32digestion (GO:0007586)4.27882385
33hormone catabolic process (GO:0042447)4.27308713
34alkaloid metabolic process (GO:0009820)4.24773580
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.24002515
36sulfate transmembrane transport (GO:1902358)4.19863255
37regulation of vitamin metabolic process (GO:0030656)4.17447135
38glucose 6-phosphate metabolic process (GO:0051156)4.17219063
39plasma lipoprotein particle assembly (GO:0034377)4.11976571
40lipoprotein metabolic process (GO:0042157)4.11698279
41regulation of cholesterol esterification (GO:0010872)4.01862071
42epithelial structure maintenance (GO:0010669)3.99718084
43regulation of triglyceride catabolic process (GO:0010896)3.95002263
44glycolipid catabolic process (GO:0019377)3.91046039
45regulation of cholesterol homeostasis (GO:2000188)3.90628647
46O-glycan processing (GO:0016266)3.89186819
47glycosphingolipid catabolic process (GO:0046479)3.87649802
48positive regulation of lipoprotein lipase activity (GO:0051006)3.87433649
49positive regulation of triglyceride lipase activity (GO:0061365)3.87433649
50protein-lipid complex assembly (GO:0065005)3.86928985
51bicarbonate transport (GO:0015701)3.85453651
52adhesion of symbiont to host cell (GO:0044650)3.84852817
53virion attachment to host cell (GO:0019062)3.84852817
54sulfation (GO:0051923)3.83709540
55endocrine pancreas development (GO:0031018)3.80631574
56nitrogen cycle metabolic process (GO:0071941)3.80221882
57membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.76622080
58transcytosis (GO:0045056)3.73318792
59positive regulation of pseudopodium assembly (GO:0031274)3.70788205
60positive regulation of respiratory burst (GO:0060267)3.65979545
61vitamin transmembrane transport (GO:0035461)3.65207584
62regulation of cGMP metabolic process (GO:0030823)3.64201179
63modified amino acid transport (GO:0072337)3.63619719
64antibacterial humoral response (GO:0019731)3.62768463
65cholesterol efflux (GO:0033344)3.61312281
66cGMP-mediated signaling (GO:0019934)3.60555006
67sperm capacitation (GO:0048240)3.57318939
68cholesterol homeostasis (GO:0042632)3.57102759
69antimicrobial humoral response (GO:0019730)3.55597438
70sterol homeostasis (GO:0055092)3.55354025
71very-low-density lipoprotein particle assembly (GO:0034379)3.54009531
72nucleotide-sugar metabolic process (GO:0009225)3.53293082
73transepithelial transport (GO:0070633)3.52381941
74fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52223995
75nucleotide-sugar biosynthetic process (GO:0009226)3.51439790
76positive regulation of glycoprotein biosynthetic process (GO:0010560)3.47230018
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46625343
78COPII vesicle coating (GO:0048208)3.46538569
79regulation of Golgi to plasma membrane protein transport (GO:0042996)3.43197241
80NADH metabolic process (GO:0006734)3.41816454
81sulfate transport (GO:0008272)3.38271507
82sulfur compound transport (GO:0072348)3.37308703
83cholesterol transport (GO:0030301)3.36318449
84sterol transport (GO:0015918)3.36318449
85negative regulation of cholesterol transport (GO:0032375)3.35640866
86negative regulation of sterol transport (GO:0032372)3.35640866
87glandular epithelial cell differentiation (GO:0002067)3.34972935
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33147434
89regulation of pseudopodium assembly (GO:0031272)3.32535183
90cellular response to nitric oxide (GO:0071732)3.32336573
91membrane repolarization during action potential (GO:0086011)3.30830417
92lipoprotein transport (GO:0042953)3.30221703
93ventricular cardiac muscle cell action potential (GO:0086005)3.29693172
94ethanol oxidation (GO:0006069)3.29369412
95peptide catabolic process (GO:0043171)3.27379239
96nucleoside diphosphate biosynthetic process (GO:0009133)3.26883079
97vitamin transport (GO:0051180)3.25379571
98glutamine family amino acid biosynthetic process (GO:0009084)3.24256597
99regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.22336404
100renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.21045714
101arginine metabolic process (GO:0006525)3.20943742
102phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.20813589
103positive regulation of fatty acid biosynthetic process (GO:0045723)3.20621257
104drinking behavior (GO:0042756)3.19918151
105regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.19623200
106positive regulation of cGMP biosynthetic process (GO:0030828)3.19387085
107glycosylceramide metabolic process (GO:0006677)3.18097112
108positive regulation of glycoprotein metabolic process (GO:1903020)3.17896538
109bile acid metabolic process (GO:0008206)3.17853685
110sphingomyelin metabolic process (GO:0006684)3.16129304
111antigen processing and presentation of endogenous antigen (GO:0019883)3.15572490
112positive regulation of lipid catabolic process (GO:0050996)3.14903640
113auditory receptor cell differentiation (GO:0042491)3.13954735
114glycerol metabolic process (GO:0006071)3.12172697
115disruption of cells of other organism (GO:0044364)3.12161690
116killing of cells of other organism (GO:0031640)3.12161690
117fat-soluble vitamin metabolic process (GO:0006775)3.12076923
118ceramide catabolic process (GO:0046514)3.10648501
119glomerular filtration (GO:0003094)3.09606667
120COPI coating of Golgi vesicle (GO:0048205)3.09151257
121Golgi transport vesicle coating (GO:0048200)3.09151257
122columnar/cuboidal epithelial cell development (GO:0002066)3.07637246
123calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.05604886
124regulation of actin nucleation (GO:0051125)3.05485844
125cellular response to reactive nitrogen species (GO:1902170)3.04807328
126regulation of systemic arterial blood pressure by hormone (GO:0001990)3.03336605
127regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.03336605
128endocrine process (GO:0050886)3.03336605
129diacylglycerol metabolic process (GO:0046339)3.03248067
130oligosaccharide catabolic process (GO:0009313)3.02067638
131oligosaccharide biosynthetic process (GO:0009312)3.01677003
132negative regulation of keratinocyte proliferation (GO:0010839)3.01481235
133sexual reproduction (GO:0019953)3.00909624
134adhesion of symbiont to host (GO:0044406)2.99381407
135drug transmembrane transport (GO:0006855)2.98760084
136thyroid hormone metabolic process (GO:0042403)2.96571213
137reverse cholesterol transport (GO:0043691)2.96059667
138urea metabolic process (GO:0019627)2.95909136
139urea cycle (GO:0000050)2.95909136
140exogenous drug catabolic process (GO:0042738)2.89500497
141regulation of digestive system process (GO:0044058)2.89426792
142cell communication involved in cardiac conduction (GO:0086065)2.89343390
143drug transport (GO:0015893)2.87587534
144homocysteine metabolic process (GO:0050667)2.84924401
145ethanol metabolic process (GO:0006067)2.84433637
146drug metabolic process (GO:0017144)2.84172598
147cellular glucuronidation (GO:0052695)2.82992552
148intestinal absorption (GO:0050892)11.4249420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.32625241
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.88452895
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.41669625
4GATA4_25053715_ChIP-Seq_YYC3_Human3.37145177
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.26482773
6GATA6_25053715_ChIP-Seq_YYC3_Human3.13727935
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.00238989
8SOX2_20726797_ChIP-Seq_SW620_Human2.99434853
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.90955755
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90534768
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.71218069
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.65979623
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.64707995
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.56107102
15SRY_22984422_ChIP-ChIP_TESTIS_Rat2.08217785
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95172066
17KLF5_25053715_ChIP-Seq_YYC3_Human1.92696063
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.88784844
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85808760
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84888960
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78495364
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.77873039
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.76442514
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74117217
25ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74042283
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71231683
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63748379
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62126517
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62019531
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.61506937
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.60632018
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56514651
33GATA1_22025678_ChIP-Seq_K562_Human1.56239440
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53018820
35AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53012090
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51526015
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.47942095
38HNF4A_19822575_ChIP-Seq_HepG2_Human1.46752704
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43992541
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.43640918
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.41961305
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.41227818
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37530566
44EZH2_22144423_ChIP-Seq_EOC_Human1.36972139
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34093921
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33824244
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27645699
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25851741
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25683759
50BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24524171
51BCAT_22108803_ChIP-Seq_LS180_Human1.21028083
52RACK7_27058665_Chip-Seq_MCF-7_Human1.20498190
53LXR_22292898_ChIP-Seq_THP-1_Human1.19671445
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19556620
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19352894
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19273895
57DROSHA_22980978_ChIP-Seq_HELA_Human1.18303493
58ATF3_27146783_Chip-Seq_COLON_Human1.17549211
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17283646
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.17113211
61FOXA1_25552417_ChIP-Seq_VCAP_Human1.15935067
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.13893980
63AR_21909140_ChIP-Seq_LNCAP_Human1.13025540
64GATA2_19941826_ChIP-Seq_K562_Human1.09656889
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07849008
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07238285
67ZNF263_19887448_ChIP-Seq_K562_Human1.06454508
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06380181
69* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04482705
70CREB1_26743006_Chip-Seq_LNCaP_Human1.03802980
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03797537
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03133423
73VDR_22108803_ChIP-Seq_LS180_Human1.02675011
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02113595
75CEBPB_22108803_ChIP-Seq_LS180_Human1.01703542
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01071426
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00317679
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.00088668
79P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99996092
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99889475
81GATA1_19941826_ChIP-Seq_K562_Human0.99539503
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98465006
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98102817
84RXR_22108803_ChIP-Seq_LS180_Human0.97157004
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96576858
86GATA3_24758297_ChIP-Seq_MCF-7_Human0.94351473
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93669059
88VDR_24787735_ChIP-Seq_THP-1_Human0.92501879
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90716573
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90201897
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89777039
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88833826
93BCOR_27268052_Chip-Seq_Bcells_Human0.88259972
94IRF8_27001747_Chip-Seq_BMDM_Mouse0.87863784
95* CDX2_22108803_ChIP-Seq_LS180_Human0.87814392
96EGR1_19032775_ChIP-ChIP_M12_Human0.87354064
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.85369525
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84380009
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83932156
100SA1_27219007_Chip-Seq_Bcells_Human0.83135255
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82879978
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82355089
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82233580
104* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81821916
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81706044
106CLOCK_20551151_ChIP-Seq_293T_Human0.80385573
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79791559
108JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79513819
109STAT1_20625510_ChIP-Seq_HELA_Human0.79392723
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78682845
111TP53_16413492_ChIP-PET_HCT116_Human0.78682579
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.78510114
113RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78280416
114* NANOG_20526341_ChIP-Seq_ESCs_Human0.78269038
115* BCL6_27268052_Chip-Seq_Bcells_Human0.77960949
116KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77870028
117TP63_22573176_ChIP-Seq_HFKS_Human0.77268549
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77158331
119FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76774407
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76449684
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.75576226
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.75390942
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75235506
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75235506
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.75017413
126VDR_24763502_ChIP-Seq_THP-1_Human0.74890125
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74768678
128TP63_23658742_ChIP-Seq_EP156T_Human0.74514792
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74396348
130CTCF_27219007_Chip-Seq_Bcells_Human0.74362334
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.74221725
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74134364
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73847531
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73355416
135GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73114594
136STAT1_17558387_ChIP-Seq_HELA_Human0.72124242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.98982494
2MP0001666_abnormal_nutrient_absorption5.45153809
3MP0002139_abnormal_hepatobiliary_system4.47571854
4MP0004264_abnormal_extraembryonic_tissu4.37979150
5MP0010234_abnormal_vibrissa_follicle4.21694581
6MP0000462_abnormal_digestive_system4.20561578
7MP0005085_abnormal_gallbladder_physiolo3.52925199
8MP0003183_abnormal_peptide_metabolism3.46920152
9MP0002822_catalepsy3.26639558
10MP0009840_abnormal_foam_cell3.05143641
11MP0003283_abnormal_digestive_organ2.95783942
12MP0003252_abnormal_bile_duct2.90453742
13MP0008875_abnormal_xenobiotic_pharmacok2.86150301
14* MP0003866_abnormal_defecation2.81445383
15MP0005365_abnormal_bile_salt2.72585889
16MP0005381_digestive/alimentary_phenotyp2.35324384
17MP0001664_abnormal_digestion2.31826146
18MP0004043_abnormal_pH_regulation2.25113438
19MP0001663_abnormal_digestive_system2.22455840
20MP0000538_abnormal_urinary_bladder2.14568751
21MP0010329_abnormal_lipoprotein_level2.13824644
22MP0005409_darkened_coat_color2.12150915
23MP0010155_abnormal_intestine_physiology2.09522944
24MP0003300_gastrointestinal_ulcer2.05290565
25MP0000537_abnormal_urethra_morphology2.01563480
26MP0001873_stomach_inflammation1.89427030
27MP0000477_abnormal_intestine_morphology1.87207745
28MP0005377_hearing/vestibular/ear_phenot1.83800771
29MP0003878_abnormal_ear_physiology1.83800771
30MP0000490_abnormal_crypts_of1.74205423
31MP0010352_gastrointestinal_tract_polyps1.64986119
32MP0004019_abnormal_vitamin_homeostasis1.62913741
33MP0005670_abnormal_white_adipose1.60464097
34MP0009780_abnormal_chondrocyte_physiolo1.53523083
35MP0003868_abnormal_feces_composition1.49680157
36MP0006054_spinal_hemorrhage1.43640029
37MP0001188_hyperpigmentation1.42432611
38MP0002909_abnormal_adrenal_gland1.40187064
39MP0002138_abnormal_hepatobiliary_system1.37655975
40MP0005167_abnormal_blood-brain_barrier1.33847506
41MP0005448_abnormal_energy_balance1.28821721
42MP0004147_increased_porphyrin_level1.27533835
43MP0010386_abnormal_urinary_bladder1.26129353
44MP0005451_abnormal_body_composition1.23203649
45MP0001765_abnormal_ion_homeostasis1.22679235
46MP0009643_abnormal_urine_homeostasis1.21665972
47MP0002136_abnormal_kidney_physiology1.19742231
48MP0005084_abnormal_gallbladder_morpholo1.17793760
49MP0004782_abnormal_surfactant_physiolog1.16915034
50MP0004858_abnormal_nervous_system1.16789909
51MP0003724_increased_susceptibility_to1.08751799
52MP0000465_gastrointestinal_hemorrhage1.06138255
53MP0000678_abnormal_parathyroid_gland1.05646119
54MP0009379_abnormal_foot_pigmentation1.05535914
55MP0001849_ear_inflammation1.03553482
56MP0002254_reproductive_system_inflammat1.02338538
57MP0000613_abnormal_salivary_gland1.02128249
58MP0008872_abnormal_physiological_respon1.00470749
59MP0002796_impaired_skin_barrier1.00017936
60MP0003806_abnormal_nucleotide_metabolis0.98790782
61MP0003191_abnormal_cellular_cholesterol0.98538113
62MP0005636_abnormal_mineral_homeostasis0.98413539
63MP0003705_abnormal_hypodermis_morpholog0.94917555
64MP0000230_abnormal_systemic_arterial0.94576292
65MP0002971_abnormal_brown_adipose0.92862453
66MP0008004_abnormal_stomach_pH0.92546799
67MP0005310_abnormal_salivary_gland0.90724833
68MP0002118_abnormal_lipid_homeostasis0.90200033
69MP0002166_altered_tumor_susceptibility0.88642860
70MP0001845_abnormal_inflammatory_respons0.88158999
71MP0005584_abnormal_enzyme/coenzyme_acti0.87688309
72MP0000516_abnormal_urinary_system0.87120103
73MP0005367_renal/urinary_system_phenotyp0.87120103
74MP0002693_abnormal_pancreas_physiology0.86352311
75MP0000609_abnormal_liver_physiology0.83681226
76MP0000470_abnormal_stomach_morphology0.81238885
77MP0005535_abnormal_body_temperature0.79461658
78MP0002098_abnormal_vibrissa_morphology0.79450865
79MP0009115_abnormal_fat_cell0.78209852
80MP0005332_abnormal_amino_acid0.78011599
81MP0000467_abnormal_esophagus_morphology0.77906496
82MP0009697_abnormal_copulation0.77498261
83MP0002089_abnormal_postnatal_growth/wei0.77348082
84MP0005187_abnormal_penis_morphology0.76505717
85MP0010678_abnormal_skin_adnexa0.74709265
86MP0004270_analgesia0.74019123
87MP0009384_cardiac_valve_regurgitation0.72331341
88MP0004947_skin_inflammation0.71705202
89MP0001764_abnormal_homeostasis0.70645729
90MP0008469_abnormal_protein_level0.70127270
91MP0003303_peritoneal_inflammation0.68728010
92MP0001835_abnormal_antigen_presentation0.68278522
93MP0003119_abnormal_digestive_system0.67763417
94MP0006082_CNS_inflammation0.66743303
95MP0002277_abnormal_respiratory_mucosa0.66268585
96MP0003453_abnormal_keratinocyte_physiol0.66072294
97MP0005666_abnormal_adipose_tissue0.66022621
98MP0001944_abnormal_pancreas_morphology0.65974089
99MP0002078_abnormal_glucose_homeostasis0.65083415
100MP0002396_abnormal_hematopoietic_system0.63775862
101MP0002006_tumorigenesis0.63561065
102MP0002163_abnormal_gland_morphology0.63340804
103MP0003953_abnormal_hormone_level0.62305931
104MP0005379_endocrine/exocrine_gland_phen0.62177235
105MP0005248_abnormal_Harderian_gland0.61628249
106MP0005166_decreased_susceptibility_to0.61559113
107MP0005220_abnormal_exocrine_pancreas0.59550144
108MP0001756_abnormal_urination0.59237385
109MP0005058_abnormal_lysosome_morphology0.59084439
110MP0002896_abnormal_bone_mineralization0.58297690
111MP0002876_abnormal_thyroid_physiology0.57918931
112MP0000249_abnormal_blood_vessel0.56866688
113* MP0005025_abnormal_response_to0.56803731
114MP0003879_abnormal_hair_cell0.56250948
115MP0003436_decreased_susceptibility_to0.55891902
116MP0000566_synostosis0.55284480
117MP0000569_abnormal_digit_pigmentation0.54974775
118MP0003315_abnormal_perineum_morphology0.54132189
119MP0005319_abnormal_enzyme/_coenzyme0.53079756
120MP0001790_abnormal_immune_system0.52710476
121MP0005387_immune_system_phenotype0.52710476
122MP0002009_preneoplasia0.52475552
123MP0009764_decreased_sensitivity_to0.52179108
124MP0003693_abnormal_embryo_hatching0.52070626
125MP0009642_abnormal_blood_homeostasis0.51045073
126MP0001216_abnormal_epidermal_layer0.50443676
127MP0005266_abnormal_metabolism0.48776524
128MP0000604_amyloidosis0.48672421
129MP0001881_abnormal_mammary_gland0.48628871
130MP0003718_maternal_effect0.48162103
131MP0000427_abnormal_hair_cycle0.48152206
132MP0004484_altered_response_of0.48069831
133MP0001485_abnormal_pinna_reflex0.47487359
134MP0008961_abnormal_basal_metabolism0.46042089
135MP0001501_abnormal_sleep_pattern0.45971226
136MP0009333_abnormal_splenocyte_physiolog0.45744322
137MP0005501_abnormal_skin_physiology0.44975021

Predicted human phenotypes

RankGene SetZ-score
1Conjugated hyperbilirubinemia (HP:0002908)6.50277565
2Right ventricular cardiomyopathy (HP:0011663)5.41352114
3Hypobetalipoproteinemia (HP:0003563)5.23419338
4Abnormality of glutamine family amino acid metabolism (HP:0010902)5.18339541
5Malnutrition (HP:0004395)5.10804676
6Acanthocytosis (HP:0001927)5.06027002
7* Ileus (HP:0002595)4.44478581
8Abdominal distention (HP:0003270)4.26542235
9Fat malabsorption (HP:0002630)4.24870177
10Chronic diarrhea (HP:0002028)3.93180897
11Systemic lupus erythematosus (HP:0002725)3.91782420
12Confusion (HP:0001289)3.91148553
13Symptomatic seizures (HP:0011145)3.88487027
14Villous atrophy (HP:0011473)3.67317969
15Abnormality of small intestinal villus morphology (HP:0011472)3.67317969
16Abnormality of the 1st metacarpal (HP:0010009)3.67281881
17Congenital sensorineural hearing impairment (HP:0008527)3.66323458
18Alkalosis (HP:0001948)3.61548041
19Intrahepatic cholestasis (HP:0001406)3.55243284
20Hydroxyprolinuria (HP:0003080)3.50311390
21Abnormality of proline metabolism (HP:0010907)3.50311390
22Hyperactive renin-angiotensin system (HP:0000841)3.48182291
23Abnormal biliary tract morphology (HP:0012440)3.37455800
24Widely patent fontanelles and sutures (HP:0004492)3.35492161
25Flat acetabular roof (HP:0003180)3.35262084
26Cupped ribs (HP:0000887)3.33746688
27Ventricular fibrillation (HP:0001663)3.31907072
28Autoimmune hemolytic anemia (HP:0001890)3.24513725
29Autoimmune thrombocytopenia (HP:0001973)3.22167612
30* Abnormality of the vitamin B12 metabolism (HP:0004341)3.21175359
31Nausea (HP:0002018)3.20222275
32Facial shape deformation (HP:0011334)3.14947819
33Potter facies (HP:0002009)3.14947819
34Rectal prolapse (HP:0002035)3.14470624
35Proximal tubulopathy (HP:0000114)3.14161262
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.11900995
37Abnormality of urine glucose concentration (HP:0011016)3.10693853
38Glycosuria (HP:0003076)3.10693853
39Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07295578
40Abnormality of chloride homeostasis (HP:0011422)3.07189275
41Abnormality of glycine metabolism (HP:0010895)3.06877038
42Abnormality of serine family amino acid metabolism (HP:0010894)3.06877038
43Progressive sensorineural hearing impairment (HP:0000408)3.03886944
44Pigmentary retinal degeneration (HP:0001146)3.03826830
45Abnormality of the gastric mucosa (HP:0004295)3.02334422
46Hypoglycemic seizures (HP:0002173)3.01246583
47Dehydration (HP:0001944)3.00954938
48Hypoglycemic coma (HP:0001325)2.98273134
49Late onset (HP:0003584)2.97064230
50* Abnormality of vitamin B metabolism (HP:0004340)2.96798577
51Hypolipoproteinemia (HP:0010981)2.96063420
52Mildly elevated creatine phosphokinase (HP:0008180)2.90712211
53Eczematoid dermatitis (HP:0000976)2.87845850
54Hyperinsulinemic hypoglycemia (HP:0000825)2.78409158
55Syncope (HP:0001279)2.78126211
56Hemorrhage of the eye (HP:0011885)2.77460703
57Hyperparathyroidism (HP:0000843)2.75477902
58Progressive hearing impairment (HP:0001730)2.75460591
59Steatorrhea (HP:0002570)2.75409940
60Metabolic alkalosis (HP:0200114)2.68414448
61Increased purine levels (HP:0004368)2.67426657
62Hyperuricemia (HP:0002149)2.67426657
63Poikilocytosis (HP:0004447)2.63995986
64Abnormal tarsal ossification (HP:0008369)2.57336580
65Hyperaldosteronism (HP:0000859)2.55976101
66Palpitations (HP:0001962)2.55538298
67Megaloblastic anemia (HP:0001889)2.55144128
68Hypercholesterolemia (HP:0003124)2.54915773
69Hyperphosphaturia (HP:0003109)2.54657798
70Pustule (HP:0200039)2.52129150
71Posterior subcapsular cataract (HP:0007787)2.47883125
72* Abnormality of vitamin metabolism (HP:0100508)2.46533254
73Focal segmental glomerulosclerosis (HP:0000097)2.44583920
74Ketoacidosis (HP:0001993)2.44553680
75Hypotension (HP:0002615)2.43073143
76Short phalanx of the thumb (HP:0009660)2.40639161
77Enlarged epiphyses (HP:0010580)2.38578102
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.38104404
79Wide cranial sutures (HP:0010537)2.36130708
80Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34245797
81Hyperglycemia (HP:0003074)2.31645294
82Male infertility (HP:0003251)2.31190821
83Abnormality of nucleobase metabolism (HP:0010932)2.29027141
84Abnormality of purine metabolism (HP:0004352)2.27895519
85Decreased circulating renin level (HP:0003351)2.26432465
86Cheilitis (HP:0100825)2.23267658
87Pili torti (HP:0003777)2.22838356
88Woolly hair (HP:0002224)2.22448644
89Delayed epiphyseal ossification (HP:0002663)2.22438883
90Abnormality of renin-angiotensin system (HP:0000847)2.20746800
91Pancreatitis (HP:0001733)2.19594978
92Hypokalemia (HP:0002900)2.17987249
93Xanthomatosis (HP:0000991)2.16352716
94Hyperphosphatemia (HP:0002905)2.16267714
95Glomerulonephritis (HP:0000099)2.14589995
96Nephrolithiasis (HP:0000787)2.14114533
97Biliary tract neoplasm (HP:0100574)2.11906869
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11148081
99Protuberant abdomen (HP:0001538)2.10780762
100Abnormal urine phosphate concentration (HP:0012599)2.10337323
101Micronodular cirrhosis (HP:0001413)2.10252029
102Prolonged QT interval (HP:0001657)2.09889850
103Gingivitis (HP:0000230)2.09806813
104Milia (HP:0001056)2.09042333
105Abnormal pancreas size (HP:0012094)2.08952157
106Bundle branch block (HP:0011710)2.08392043
107Abnormality of the costochondral junction (HP:0000919)2.08259020
108Thin bony cortex (HP:0002753)2.07930171
109Gout (HP:0001997)2.07782024
110Abnormality of pyrimidine metabolism (HP:0004353)2.06138214
111Abnormality of carpal bone ossification (HP:0006257)2.04236414
112Abnormality of complement system (HP:0005339)2.04071689
113Abnormal foot bone ossification (HP:0010675)2.04069477
114Abnormality of potassium homeostasis (HP:0011042)2.03827581
115Short 1st metacarpal (HP:0010034)2.02797713
116Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.02797713
117Fragile skin (HP:0001030)2.02527274
118Ankyloglossia (HP:0010296)2.01927419
119Complement deficiency (HP:0004431)2.01101990
120Dicarboxylic aciduria (HP:0003215)1.99372164
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99372164
122Abnormal glucose tolerance (HP:0001952)1.99227454
123Subcapsular cataract (HP:0000523)1.98658726
124Epidermoid cyst (HP:0200040)1.98217846
125Hyperglycinuria (HP:0003108)1.97747863
126Renal tubular acidosis (HP:0001947)1.97240745
127Mesangial abnormality (HP:0001966)1.95836675
128Hyperbilirubinemia (HP:0002904)1.95667949
129Abnormality of calcium-phosphate metabolism (HP:0100530)1.95437011
130Abnormality of magnesium homeostasis (HP:0004921)1.94735092
131Cerebral palsy (HP:0100021)1.93508064
132Exocrine pancreatic insufficiency (HP:0001738)1.93227428
133Curly hair (HP:0002212)1.91505239
134Metabolic acidosis (HP:0001942)1.88815274
135Increased mean platelet volume (HP:0011877)1.87746220
136Nephritis (HP:0000123)1.87188195
137Plantar hyperkeratosis (HP:0007556)1.85686304
138Hypophosphatemia (HP:0002148)1.83882254
139Hyperammonemia (HP:0001987)1.83808865
140Symphalangism affecting the phalanges of the hand (HP:0009773)1.83566398
141Hyponatremia (HP:0002902)1.83423940
142Glomerulosclerosis (HP:0000096)1.82435535
143Microretrognathia (HP:0000308)1.81932649
144Insulin resistance (HP:0000855)1.81497857
145Severe short stature (HP:0003510)1.80730507
146Segmental peripheral demyelination/remyelination (HP:0003481)1.75901831
147Petechiae (HP:0000967)1.74511322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.75833838
2LMTK26.56085681
3MST1R4.34489218
4MST43.95987031
5PRKG23.53597567
6NME12.98502573
7TAOK32.78985396
8MAP2K22.49854403
9RIPK12.49099573
10MAP3K22.36876932
11GRK62.10026898
12NUAK12.09008493
13EPHA22.03992480
14FGFR41.90920623
15INSRR1.90504724
16PTK61.88949930
17AKT31.76549982
18MAP3K101.73207095
19ERN11.70500467
20EPHA31.67086212
21STK241.55597744
22MET1.55275526
23TESK11.53150270
24EPHB21.52694921
25PIK3CA1.44299119
26TYK21.39300510
27DYRK1B1.33330410
28MAP2K61.33166663
29TESK21.33145085
30PDK21.28951470
31PTK21.25710302
32TNIK1.22941811
33LATS11.22344758
34KSR21.16331222
35MYLK1.13161464
36ERBB21.10584045
37NLK1.09623129
38MAP3K11.08046143
39PRKCI1.03694982
40FGFR31.03435749
41PRPF4B0.98135891
42TTK0.96838255
43MAP4K10.90567801
44PASK0.88468507
45ERBB40.88254218
46SIK30.86209163
47MAP2K10.82593372
48FER0.81018944
49BCR0.80560626
50MAP3K90.78495286
51PRKAA20.76832685
52IRAK10.72765304
53DDR20.71382064
54PRKAA10.70302785
55KSR10.68050880
56YES10.66467537
57MAPK150.66133424
58CASK0.65984877
59SCYL20.65163251
60CAMK2D0.61696592
61PAK30.61207339
62DMPK0.61152553
63WNK40.60799746
64MAP3K80.60576506
65PDK10.60406358
66HIPK20.58484367
67MATK0.58297842
68IRAK30.54908445
69MAP3K30.53131619
70MAPK110.52951776
71EPHA40.51726876
72STK390.51406393
73PAK40.49651777
74PIM10.47122661
75BMPR1B0.46927781
76CSK0.46518899
77RIPK40.45686896
78CDC42BPA0.45275504
79BMPR20.44885304
80CAMK2B0.44106802
81JAK20.43998835
82BRAF0.43883432
83GRK10.43298388
84CSNK1A10.43067301
85MAP3K70.42545517
86PBK0.42332036
87PRKCZ0.42147844
88ZAP700.41394393
89TAOK10.39970124
90BLK0.38631980
91JAK10.37825900
92ABL20.37511218
93TBK10.37450467
94NEK60.36247560
95EEF2K0.35497432
96EPHB10.35418588
97STK100.35189029
98CAMK2G0.34857546
99MAP3K110.34036956
100CDK60.33851816
101CDK190.33081985
102AURKB0.33076519
103SIK10.31714751
104LIMK10.31576635
105* PRKCA0.30380441
106PRKACG0.30145004
107ACVR1B0.29141247
108IKBKE0.29011515
109MAP3K140.28882279
110ROCK10.28806566
111CSF1R0.28016562
112PDPK10.27837431
113PDGFRA0.27544994
114PIK3CG0.27503587
115PRKCD0.27252641
116ICK0.27173789
117MAP3K120.26838169
118MELK0.25376959
119RET0.24395848
120MAP3K50.23854322
121CSNK1E0.23843508
122BTK0.21897137
123FGR0.21876952
124IGF1R0.21327881
125SRC0.20221944
126LYN0.19983501
127IRAK40.19851449
128PINK10.19508233
129OXSR10.18891164
130STK110.18545217
131FYN0.18261878
132PAK10.17838161
133STK30.16705797
134GSK3A0.15602740
135BMX0.15284449
136AKT20.15202221
137MAPKAPK20.14945316
138CDK50.13847307
139ARAF0.13031032
140CSNK1G10.12893421
141MAPKAPK50.12538502

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.92753440
2Sulfur metabolism_Homo sapiens_hsa009204.57561334
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.51290292
4Maturity onset diabetes of the young_Homo sapiens_hsa049504.11312251
5Mineral absorption_Homo sapiens_hsa049783.71735876
6Renin-angiotensin system_Homo sapiens_hsa046143.12919529
7Vitamin digestion and absorption_Homo sapiens_hsa049772.76832295
8Galactose metabolism_Homo sapiens_hsa000522.65131953
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.46956586
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36956506
11Starch and sucrose metabolism_Homo sapiens_hsa005002.33007408
12Bile secretion_Homo sapiens_hsa049762.19206619
13Histidine metabolism_Homo sapiens_hsa003402.16673773
14Caffeine metabolism_Homo sapiens_hsa002322.09799526
15Folate biosynthesis_Homo sapiens_hsa007901.93705714
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93239627
17Fructose and mannose metabolism_Homo sapiens_hsa000511.92870982
18Protein digestion and absorption_Homo sapiens_hsa049741.77500452
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74329617
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72520632
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67617560
22Tryptophan metabolism_Homo sapiens_hsa003801.60999640
23Nitrogen metabolism_Homo sapiens_hsa009101.48385296
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48133593
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.46111390
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33129308
27Glycerolipid metabolism_Homo sapiens_hsa005611.14601481
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11965243
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10308370
30Fatty acid degradation_Homo sapiens_hsa000711.06432135
31Pancreatic secretion_Homo sapiens_hsa049721.05291127
32ABC transporters_Homo sapiens_hsa020101.05023280
33Glutathione metabolism_Homo sapiens_hsa004801.01096991
34Arginine biosynthesis_Homo sapiens_hsa002200.99693440
35PPAR signaling pathway_Homo sapiens_hsa033200.98559831
36Arginine and proline metabolism_Homo sapiens_hsa003300.95802905
37Asthma_Homo sapiens_hsa053100.93016519
38Sphingolipid metabolism_Homo sapiens_hsa006000.90253615
39Insulin secretion_Homo sapiens_hsa049110.89734868
40Selenocompound metabolism_Homo sapiens_hsa004500.87281654
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83733680
42Vibrio cholerae infection_Homo sapiens_hsa051100.81842534
43Type II diabetes mellitus_Homo sapiens_hsa049300.79546644
44Staphylococcus aureus infection_Homo sapiens_hsa051500.78808772
45Butanoate metabolism_Homo sapiens_hsa006500.78662546
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78616813
47Thyroid hormone synthesis_Homo sapiens_hsa049180.77883760
48Tight junction_Homo sapiens_hsa045300.74614389
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.71622983
50Allograft rejection_Homo sapiens_hsa053300.70555759
51Pyruvate metabolism_Homo sapiens_hsa006200.67571949
52Cocaine addiction_Homo sapiens_hsa050300.67041342
53Autoimmune thyroid disease_Homo sapiens_hsa053200.65048468
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63195872
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62879469
56Graft-versus-host disease_Homo sapiens_hsa053320.62773643
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.62770204
58Other glycan degradation_Homo sapiens_hsa005110.62449154
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60532745
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59652775
61Retinol metabolism_Homo sapiens_hsa008300.58162102
62Linoleic acid metabolism_Homo sapiens_hsa005910.55541239
63N-Glycan biosynthesis_Homo sapiens_hsa005100.54838805
64Chemical carcinogenesis_Homo sapiens_hsa052040.54537164
65Gastric acid secretion_Homo sapiens_hsa049710.52061239
66Pentose phosphate pathway_Homo sapiens_hsa000300.48014627
67Carbon metabolism_Homo sapiens_hsa012000.47172119
68beta-Alanine metabolism_Homo sapiens_hsa004100.46880305
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46812643
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46621266
71Thyroid cancer_Homo sapiens_hsa052160.46390242
72Type I diabetes mellitus_Homo sapiens_hsa049400.45685664
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.43460676
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41933893
75Fatty acid biosynthesis_Homo sapiens_hsa000610.41781419
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41340628
77Bladder cancer_Homo sapiens_hsa052190.40950480
78Salivary secretion_Homo sapiens_hsa049700.39866520
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36732025
80Phenylalanine metabolism_Homo sapiens_hsa003600.34650385
81Leishmaniasis_Homo sapiens_hsa051400.32959601
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32751721
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32077603
84Metabolic pathways_Homo sapiens_hsa011000.31759976
85Adherens junction_Homo sapiens_hsa045200.31414874
86Lysine degradation_Homo sapiens_hsa003100.31372603
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.31163138
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30966802
89Salmonella infection_Homo sapiens_hsa051320.30965505
90Sulfur relay system_Homo sapiens_hsa041220.29570108
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29567367
92Fatty acid metabolism_Homo sapiens_hsa012120.27465359
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.26407492
94Hepatitis C_Homo sapiens_hsa051600.26058147
95Arachidonic acid metabolism_Homo sapiens_hsa005900.25184204
96Antigen processing and presentation_Homo sapiens_hsa046120.24985390
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24842308
98Propanoate metabolism_Homo sapiens_hsa006400.23405657
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.22804068
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.22800681
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22102790
102Alzheimers disease_Homo sapiens_hsa050100.21594327
103Amphetamine addiction_Homo sapiens_hsa050310.17237844
104Ether lipid metabolism_Homo sapiens_hsa005650.17234251
105Peroxisome_Homo sapiens_hsa041460.17162950
106Renin secretion_Homo sapiens_hsa049240.17117673
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16947213
108GnRH signaling pathway_Homo sapiens_hsa049120.16905507
109Pertussis_Homo sapiens_hsa051330.16756986
110Insulin resistance_Homo sapiens_hsa049310.15379502
111Glucagon signaling pathway_Homo sapiens_hsa049220.15204008
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14265470
113Parkinsons disease_Homo sapiens_hsa050120.13457672
114Oxidative phosphorylation_Homo sapiens_hsa001900.12850714
115Inositol phosphate metabolism_Homo sapiens_hsa005620.12694392
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.09865026
117Viral myocarditis_Homo sapiens_hsa054160.09773361
118African trypanosomiasis_Homo sapiens_hsa051430.08827297
119Tyrosine metabolism_Homo sapiens_hsa003500.08642141
120Biosynthesis of amino acids_Homo sapiens_hsa012300.07885664
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.07545898
122Gap junction_Homo sapiens_hsa045400.06921700
123Toxoplasmosis_Homo sapiens_hsa051450.06525939
124Complement and coagulation cascades_Homo sapiens_hsa046100.05914210
125Influenza A_Homo sapiens_hsa051640.03256048
126Tuberculosis_Homo sapiens_hsa051520.02975016

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