GUCY2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)6.32244436
2mature B cell differentiation involved in immune response (GO:0002313)5.47384944
3vocalization behavior (GO:0071625)5.44199628
4mitochondrial genome maintenance (GO:0000002)5.38244825
5regulation of female receptivity (GO:0045924)5.16746682
6immunoglobulin mediated immune response (GO:0016064)5.06950973
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.06727031
8negative regulation of muscle hypertrophy (GO:0014741)5.05098039
9regulation of dendritic cell antigen processing and presentation (GO:0002604)4.97689282
10female mating behavior (GO:0060180)4.96600614
11limb bud formation (GO:0060174)4.91493742
12sequestering of actin monomers (GO:0042989)4.68622705
13skeletal muscle tissue regeneration (GO:0043403)4.57834546
14seminiferous tubule development (GO:0072520)4.49937645
15positive thymic T cell selection (GO:0045059)4.43593239
16chaperone mediated protein folding requiring cofactor (GO:0051085)4.28260219
17cellular response to exogenous dsRNA (GO:0071360)4.25714061
18response to muscle activity (GO:0014850)4.18368320
19ribonucleoprotein complex disassembly (GO:0032988)4.15735610
20regulation of T-helper 1 cell differentiation (GO:0045625)3.97482493
21DNA dealkylation (GO:0035510)3.97334104
22striated muscle atrophy (GO:0014891)3.92320404
23behavioral response to nicotine (GO:0035095)3.91341343
24synaptonemal complex assembly (GO:0007130)3.88345868
25multicellular organism reproduction (GO:0032504)3.83217005
26negative regulation of skeletal muscle tissue development (GO:0048642)3.80752701
27mature B cell differentiation (GO:0002335)3.78218449
28synaptonemal complex organization (GO:0070193)3.78147428
29negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.72363460
30microtubule polymerization or depolymerization (GO:0031109)3.72212804
31protein polyglutamylation (GO:0018095)3.67593044
32negative regulation of cAMP-mediated signaling (GO:0043951)3.67372101
33fat-soluble vitamin catabolic process (GO:0042363)3.66876933
34vitamin catabolic process (GO:0009111)3.66876933
35axon ensheathment in central nervous system (GO:0032291)3.66492525
36central nervous system myelination (GO:0022010)3.66492525
37positive regulation of protein kinase C signaling (GO:0090037)3.65546275
38lipoxygenase pathway (GO:0019372)3.60817997
39skeletal muscle adaptation (GO:0043501)3.60532572
40B cell mediated immunity (GO:0019724)3.58158744
41negative regulation of B cell apoptotic process (GO:0002903)3.56900773
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54831229
43response to pheromone (GO:0019236)3.54175656
44phosphatidylethanolamine biosynthetic process (GO:0006646)3.52355848
45negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.50531905
46muscle atrophy (GO:0014889)3.50484455
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50424182
48neuron remodeling (GO:0016322)3.48521057
49axon extension (GO:0048675)3.47021239
50RNA destabilization (GO:0050779)3.44147307
51mast cell activation involved in immune response (GO:0002279)3.41573427
52mast cell degranulation (GO:0043303)3.41573427
53cell wall macromolecule metabolic process (GO:0044036)3.39248393
54cell wall macromolecule catabolic process (GO:0016998)3.39248393
55mitochondrial DNA replication (GO:0006264)3.38181797
56sperm motility (GO:0030317)3.37464997
57positive regulation of microtubule polymerization (GO:0031116)3.36622202
58DNA demethylation (GO:0080111)3.35904005
59acrosome assembly (GO:0001675)3.33202375
602-oxoglutarate metabolic process (GO:0006103)3.31459284
61centriole replication (GO:0007099)3.30074702
62cardiovascular system development (GO:0072358)3.29961558
63synaptic vesicle maturation (GO:0016188)3.28573709
64pyrimidine dimer repair (GO:0006290)3.28503729
65aggressive behavior (GO:0002118)3.25881006
66regulation of dendritic spine morphogenesis (GO:0061001)3.25230594
67cellular protein complex localization (GO:0034629)3.25204412
68neuron cell-cell adhesion (GO:0007158)3.21492549
69heart process (GO:0003015)3.20825758
70heart contraction (GO:0060047)3.20825758
71synaptic transmission, dopaminergic (GO:0001963)3.20771786
72regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.19220797
73plasma membrane fusion (GO:0045026)3.17792308
74male meiosis (GO:0007140)3.17485302
75base-excision repair, AP site formation (GO:0006285)3.16015266
76neurotransmitter catabolic process (GO:0042135)3.15572105
77sympathetic nervous system development (GO:0048485)3.15495312
78opsonization (GO:0008228)3.15384718
79response to epinephrine (GO:0071871)3.11043457
80regulation of germinal center formation (GO:0002634)3.10663332
81phosphatidylethanolamine metabolic process (GO:0046337)3.10563706
82relaxation of smooth muscle (GO:0044557)3.09790581
83positive regulation of systemic arterial blood pressure (GO:0003084)3.09493488
84NAD biosynthetic process (GO:0009435)3.07502624
85positive regulation of chemokine secretion (GO:0090197)3.06038426
86positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.05639483
87mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.05639483
88reproduction (GO:0000003)3.05630332
89homeostasis of number of cells within a tissue (GO:0048873)3.01129967
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00914574
91negative regulation of T-helper cell differentiation (GO:0045623)3.00914574
92deoxyribonucleotide catabolic process (GO:0009264)2.99099226
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97209095
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.97016029
95metallo-sulfur cluster assembly (GO:0031163)2.96852188
96iron-sulfur cluster assembly (GO:0016226)2.96852188
97positive T cell selection (GO:0043368)2.96530014
98positive regulation of glycoprotein biosynthetic process (GO:0010560)2.96401193
99positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.94806322
100centriole assembly (GO:0098534)2.92951488
101valine metabolic process (GO:0006573)2.91887530
102DNA deamination (GO:0045006)2.90310252
103positive regulation of action potential (GO:0045760)2.90147895
104negative regulation of glial cell proliferation (GO:0060253)2.87826328
105negative thymic T cell selection (GO:0045060)2.87587595
106response to testosterone (GO:0033574)2.87434099
107purine deoxyribonucleotide catabolic process (GO:0009155)2.87117129
108protein targeting to vacuole (GO:0006623)2.85450801
109protein targeting to lysosome (GO:0006622)2.85450801
110establishment of protein localization to vacuole (GO:0072666)2.85450801
111regulation of chemokine secretion (GO:0090196)2.83688233
112positive regulation of gastrulation (GO:2000543)2.82875351
113amino acid salvage (GO:0043102)2.82624030
114L-methionine salvage (GO:0071267)2.82624030
115L-methionine biosynthetic process (GO:0071265)2.82624030
116thyroid gland development (GO:0030878)2.82481071
117acrosome reaction (GO:0007340)2.81924800
118synapsis (GO:0007129)2.81814164
119cornea development in camera-type eye (GO:0061303)2.81464158
120neuron projection extension (GO:1990138)2.81037657
121renal system process involved in regulation of blood volume (GO:0001977)2.80795842
122regulation of T-helper 2 cell differentiation (GO:0045628)2.80773437
123anterograde synaptic vesicle transport (GO:0048490)2.79112334
124embryonic retina morphogenesis in camera-type eye (GO:0060059)2.78737499
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.76933315
126neuron recognition (GO:0008038)2.76857543
127sphingosine metabolic process (GO:0006670)2.75301134
128pyrimidine nucleotide catabolic process (GO:0006244)2.75015783
129keratinocyte proliferation (GO:0043616)2.73773972
130regulation of protein kinase C signaling (GO:0090036)2.71793454
131retina layer formation (GO:0010842)2.70887283
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70793242
133postsynaptic membrane organization (GO:0001941)2.69520460
134cellular response to dexamethasone stimulus (GO:0071549)2.68677271
135imidazole-containing compound metabolic process (GO:0052803)2.67431564
136intraspecies interaction between organisms (GO:0051703)2.67116525
137social behavior (GO:0035176)2.67116525
138positive regulation of antigen processing and presentation (GO:0002579)2.67081717
139regulation of metalloenzyme activity (GO:0048552)2.66751088
140regulation of dendritic spine development (GO:0060998)2.66070679
141positive regulation of fatty acid transport (GO:2000193)2.66038603
142deoxyribose phosphate catabolic process (GO:0046386)2.65904315
143negative regulation of type 2 immune response (GO:0002829)2.65581450
144L-fucose catabolic process (GO:0042355)2.65488301
145fucose catabolic process (GO:0019317)2.65488301
146L-fucose metabolic process (GO:0042354)2.65488301
147microtubule severing (GO:0051013)2.65212419
148protein neddylation (GO:0045116)2.65118897
149fatty acid elongation (GO:0030497)2.64965449
150chromosome organization involved in meiosis (GO:0070192)2.64946775
151mast cell activation (GO:0045576)2.64464661
152organic cation transport (GO:0015695)2.64182317
153regulation of B cell apoptotic process (GO:0002902)2.63900245
154heterotypic cell-cell adhesion (GO:0034113)2.63737246
155phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.62655951
156dendritic spine morphogenesis (GO:0060997)2.62352992
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60172573
158lysosome localization (GO:0032418)2.59960036
159layer formation in cerebral cortex (GO:0021819)2.59921017
160long-chain fatty acid biosynthetic process (GO:0042759)2.59717303
161thymic T cell selection (GO:0045061)2.59426688
162positive regulation of synapse assembly (GO:0051965)2.58174681
163sperm-egg recognition (GO:0035036)2.58049791
164spermatid development (GO:0007286)2.57003400
165positive regulation of gamma-delta T cell activation (GO:0046645)2.56003442
166potassium ion homeostasis (GO:0055075)2.55105516
167fucosylation (GO:0036065)2.54961862
168negative T cell selection (GO:0043383)2.54875278
169regulation of antigen processing and presentation (GO:0002577)2.54418032
170response to dexamethasone (GO:0071548)2.54198225
171L-amino acid import (GO:0043092)2.53723186
172single fertilization (GO:0007338)2.52438563
173single strand break repair (GO:0000012)2.51820338
174fusion of sperm to egg plasma membrane (GO:0007342)2.49831293
175left/right axis specification (GO:0070986)2.49566950
176myelination (GO:0042552)2.49477957
177eyelid development in camera-type eye (GO:0061029)2.48893507
178negative regulation of neurotransmitter secretion (GO:0046929)2.48252834
179diol metabolic process (GO:0034311)2.47595093
180axonal fasciculation (GO:0007413)2.44864158
181presynaptic membrane assembly (GO:0097105)2.44139330
182microtubule depolymerization (GO:0007019)2.42898276
183positive regulation of glycoprotein metabolic process (GO:1903020)2.42556283
184presynaptic membrane organization (GO:0097090)2.42296544
185L-ascorbic acid metabolic process (GO:0019852)2.41315749
186detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.40846364
187detection of temperature stimulus involved in sensory perception (GO:0050961)2.40846364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.18438616
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.24994820
3EZH2_22144423_ChIP-Seq_EOC_Human3.95415894
4VDR_22108803_ChIP-Seq_LS180_Human3.53250501
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18607858
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.74357398
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.72572349
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.66086199
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.62946577
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61558329
11ELF1_20517297_ChIP-Seq_JURKAT_Human2.58568854
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56938218
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45279173
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.45163777
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42132850
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38313632
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38313632
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.36701299
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35274526
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.29936727
21STAT1_20625510_ChIP-Seq_HELA_Human2.27135540
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24360195
23DROSHA_22980978_ChIP-Seq_HELA_Human2.21526655
24BCL6_27268052_Chip-Seq_Bcells_Human2.20704162
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16666290
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12570536
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11219165
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10824051
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10021574
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.06530117
31SCL_19346495_ChIP-Seq_HPC-7_Human2.05681166
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.04420551
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04099123
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96386094
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92812927
36CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.89120789
37VDR_21846776_ChIP-Seq_THP-1_Human1.86486615
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.85393956
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82578203
40TAF2_19829295_ChIP-Seq_ESCs_Human1.81934752
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.81229620
42PHF8_20622854_ChIP-Seq_HELA_Human1.78630527
43E2F1_20622854_ChIP-Seq_HELA_Human1.78397565
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76533703
45ZNF274_21170338_ChIP-Seq_K562_Hela1.76492231
46RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.74893721
47P68_20966046_ChIP-Seq_HELA_Human1.74679472
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73957160
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70738769
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70061759
51ERA_21632823_ChIP-Seq_H3396_Human1.69268677
52CIITA_25753668_ChIP-Seq_RAJI_Human1.68500496
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67516237
54BCOR_27268052_Chip-Seq_Bcells_Human1.66924108
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65602235
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62655928
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60719672
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.59754522
59RAC3_21632823_ChIP-Seq_H3396_Human1.56363934
60VDR_24763502_ChIP-Seq_THP-1_Human1.56284782
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.54698269
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.54475448
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53993309
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.52857675
65P300_27268052_Chip-Seq_Bcells_Human1.51827025
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50736778
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49889405
68TP53_18474530_ChIP-ChIP_U2OS_Human1.48315919
69RUNX_20019798_ChIP-Seq_JUKART_Human1.47559528
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.45150311
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42236248
72OCT4_19829295_ChIP-Seq_ESCs_Human1.41502869
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.40903721
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40459834
75SPI1_23127762_ChIP-Seq_K562_Human1.39323270
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.39020378
77* REST_21632747_ChIP-Seq_MESCs_Mouse1.38439912
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.38406483
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.38363310
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37112305
81GATA3_27048872_Chip-Seq_THYMUS_Human1.36628664
82* CTCF_20526341_ChIP-Seq_ESCs_Human1.36384851
83TAF15_26573619_Chip-Seq_HEK293_Human1.35657999
84* SOX2_21211035_ChIP-Seq_LN229_Human1.32572798
85* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32388819
86MYB_26560356_Chip-Seq_TH2_Human1.32240167
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.31154150
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30121158
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.30112562
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29472151
91* GATA3_21878914_ChIP-Seq_MCF-7_Human1.29317717
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28885298
93GBX2_23144817_ChIP-Seq_PC3_Human1.28378484
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26648788
95GATA3_26560356_Chip-Seq_TH2_Human1.25619401
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.25352289
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24155509
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.22139397
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.21834498
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21708315
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20981462
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18916766
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.18275434
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17322656
105CTCF_27219007_Chip-Seq_Bcells_Human1.15671258
106ETS1_21867929_ChIP-Seq_TH2_Mouse1.13855169
107* FOXA1_25329375_ChIP-Seq_VCAP_Human1.12722456
108* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12722456
109ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12571382
110* MYC_19829295_ChIP-Seq_ESCs_Human1.12524628
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12184682
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11946888
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.11603406
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11264436
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11077845
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11036784
117* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10935230
118* SPI1_23547873_ChIP-Seq_NB4_Human1.10882567
119EP300_21415370_ChIP-Seq_HL-1_Mouse1.10593167
120LXR_22292898_ChIP-Seq_THP-1_Human1.10091667
121SPI1_20517297_ChIP-Seq_HL60_Human1.08205014
122CJUN_26792858_Chip-Seq_BT549_Human1.08202921
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07059671
124SMRT_27268052_Chip-Seq_Bcells_Human1.05938456
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04692215
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04669211
127OCT4_20526341_ChIP-Seq_ESCs_Human1.04232148
128* SMC4_20622854_ChIP-Seq_HELA_Human1.03843222
129TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03486017
130GATA1_19941827_ChIP-Seq_MEL_Mouse1.02475259
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02280477
132NCOR_22424771_ChIP-Seq_293T_Human1.02263870
133NANOG_20526341_ChIP-Seq_ESCs_Human1.01890999
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00944874
135* TP63_22573176_ChIP-Seq_HFKS_Human1.00731867
136* UTX_26944678_Chip-Seq_JUKART_Human1.00710208
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00592223
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00395657
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.99321965
140CTCF_21964334_Chip-Seq_Bcells_Human0.99010563
141SA1_27219007_Chip-Seq_Bcells_Human0.98334772
142SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98239480
143GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97656975
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97408575
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.97270618
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96894104
147P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96621285
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96377420
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.95859472
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.95328554
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95129438
152PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94562007
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94312036
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92491641
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.92378922
156FLI1_21867929_ChIP-Seq_CD8_Mouse0.91928511
157VDR_24787735_ChIP-Seq_THP-1_Human0.91734264
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91261621
159AR_21572438_ChIP-Seq_LNCaP_Human0.90916683
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90781809
161MYC_19915707_ChIP-ChIP_AK7_Human0.90436141
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90404546
163TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90050779
164POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90050779
165TAL1_26923725_Chip-Seq_HPCs_Mouse0.89800725
166REST_18959480_ChIP-ChIP_MESCs_Mouse0.88824348
167RNF2_27304074_Chip-Seq_NSC_Mouse0.88365239
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.88328532
169WT1_19549856_ChIP-ChIP_CCG9911_Human0.88269051
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.88184880
171TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88011210
172PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87750956
173CMYC_18555785_Chip-Seq_ESCs_Mouse0.87219034
174IRF1_19129219_ChIP-ChIP_H3396_Human0.85982432
175FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85585130
176WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85373673
177* RUNX2_22187159_ChIP-Seq_PCA_Human0.85111313
178TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84472223
179SMAD4_21799915_ChIP-Seq_A2780_Human0.83869719
180TP53_16413492_ChIP-PET_HCT116_Human0.83077052
181IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82337623
182CBP_20019798_ChIP-Seq_JUKART_Human0.82337623
183VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81895147
184* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81281004
185THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80960681
186PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80584796
187GF1_26923725_Chip-Seq_HPCs_Mouse0.79778630
188P53_22387025_ChIP-Seq_ESCs_Mouse0.78939308
189ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78542737
190SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78297643
191BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78234841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology5.16902104
2MP0009840_abnormal_foam_cell4.94833784
3MP0003787_abnormal_imprinting4.32089838
4MP0008438_abnormal_cutaneous_collagen3.82931001
5MP0005410_abnormal_fertilization3.80977477
6MP0003011_delayed_dark_adaptation3.41753107
7MP0001958_emphysema3.34234556
8MP0002089_abnormal_postnatal_growth/wei3.06250921
9MP0003880_abnormal_central_pattern3.04679555
10MP0004270_analgesia2.90660835
11MP0005075_abnormal_melanosome_morpholog2.84089256
12MP0000681_abnormal_thyroid_gland2.72806185
13MP0000569_abnormal_digit_pigmentation2.68053719
14MP0005503_abnormal_tendon_morphology2.56320054
15MP0003436_decreased_susceptibility_to2.55796854
16MP0004859_abnormal_synaptic_plasticity2.52584517
17MP0002132_abnormal_respiratory_system2.40925036
18MP0006292_abnormal_olfactory_placode2.40139113
19MP0000678_abnormal_parathyroid_gland2.35360255
20MP0002735_abnormal_chemical_nociception2.24774736
21MP0009278_abnormal_bone_marrow2.23983491
22MP0002822_catalepsy2.22918665
23MP0005084_abnormal_gallbladder_morpholo2.21524999
24MP0005623_abnormal_meninges_morphology2.19821523
25MP0004742_abnormal_vestibular_system2.10390005
26MP0005275_abnormal_skin_tensile2.04602144
27MP0002148_abnormal_hypersensitivity_rea1.98462116
28MP0002734_abnormal_mechanical_nocicepti1.92265724
29MP0000920_abnormal_myelination1.90177051
30MP0002653_abnormal_ependyma_morphology1.84817755
31MP0003941_abnormal_skin_development1.82896594
32MP0001835_abnormal_antigen_presentation1.82413748
33MP0009764_decreased_sensitivity_to1.79514569
34MP0005647_abnormal_sex_gland1.76361762
35MP0003303_peritoneal_inflammation1.74374787
36MP0008995_early_reproductive_senescence1.73150977
37MP0002108_abnormal_muscle_morphology1.72838202
38MP0004782_abnormal_surfactant_physiolog1.70864397
39MP0003279_aneurysm1.70533750
40MP0005058_abnormal_lysosome_morphology1.67045636
41MP0005423_abnormal_somatic_nervous1.65933229
42MP0003878_abnormal_ear_physiology1.63754318
43MP0005377_hearing/vestibular/ear_phenot1.63754318
44MP0000778_abnormal_nervous_system1.62787292
45MP0006276_abnormal_autonomic_nervous1.60024963
46MP0002876_abnormal_thyroid_physiology1.57982979
47MP0002295_abnormal_pulmonary_circulatio1.55101752
48MP0002249_abnormal_larynx_morphology1.55089531
49MP0004134_abnormal_chest_morphology1.51830335
50MP0003385_abnormal_body_wall1.50886849
51MP0009379_abnormal_foot_pigmentation1.48433752
52MP0002896_abnormal_bone_mineralization1.45741710
53MP0002102_abnormal_ear_morphology1.44703452
54MP0002184_abnormal_innervation1.44589587
55MP0001486_abnormal_startle_reflex1.44055254
56MP0001853_heart_inflammation1.44001548
57MP0002638_abnormal_pupillary_reflex1.42575961
58MP0003635_abnormal_synaptic_transmissio1.42095119
59MP0002837_dystrophic_cardiac_calcinosis1.41673941
60MP0002272_abnormal_nervous_system1.41362040
61MP0001545_abnormal_hematopoietic_system1.38653408
62MP0005397_hematopoietic_system_phenotyp1.38653408
63MP0001968_abnormal_touch/_nociception1.38069050
64MP0004381_abnormal_hair_follicle1.36907330
65MP0005464_abnormal_platelet_physiology1.35219070
66MP0005000_abnormal_immune_tolerance1.35152112
67MP0001485_abnormal_pinna_reflex1.34180213
68MP0003806_abnormal_nucleotide_metabolis1.33704535
69MP0005360_urolithiasis1.32612033
70MP0001851_eye_inflammation1.29130239
71MP0003698_abnormal_male_reproductive1.26965237
72MP0003121_genomic_imprinting1.25804218
73MP0005174_abnormal_tail_pigmentation1.25022097
74MP0005451_abnormal_body_composition1.23956065
75MP0000343_altered_response_to1.23183522
76MP0003195_calcinosis1.22032776
77MP0003123_paternal_imprinting1.21981058
78MP0005595_abnormal_vascular_smooth1.21720642
79MP0003879_abnormal_hair_cell1.18912234
80MP0008877_abnormal_DNA_methylation1.18697221
81MP0000955_abnormal_spinal_cord1.18630819
82MP0000230_abnormal_systemic_arterial1.17467765
83MP0002064_seizures1.14448652
84MP0003959_abnormal_lean_body1.14316467
85MP0003045_fibrosis1.13897269
86MP0001800_abnormal_humoral_immune1.13509166
87MP0000015_abnormal_ear_pigmentation1.13118378
88MP0003646_muscle_fatigue1.12029999
89MP0001293_anophthalmia1.11941582
90MP0001929_abnormal_gametogenesis1.11673869
91MP0002233_abnormal_nose_morphology1.10612215
92MP0005409_darkened_coat_color1.10211352
93MP0002557_abnormal_social/conspecific_i1.10101227
94MP0001727_abnormal_embryo_implantation1.09566068
95MP0005670_abnormal_white_adipose1.08948135
96MP0001501_abnormal_sleep_pattern1.08878262
97MP0005171_absent_coat_pigmentation1.06984610
98MP0002405_respiratory_system_inflammati1.06953426
99MP0002419_abnormal_innate_immunity1.06222808
100MP0002723_abnormal_immune_serum1.02705649
101MP0002160_abnormal_reproductive_system1.01577113
102MP0003724_increased_susceptibility_to0.99233815
103MP0000685_abnormal_immune_system0.98236470
104MP0001502_abnormal_circadian_rhythm0.98112899
105MP0005025_abnormal_response_to0.95690771
106MP0003186_abnormal_redox_activity0.95589520
107MP0003938_abnormal_ear_development0.94801439
108MP0004085_abnormal_heartbeat0.94763848
109MP0002736_abnormal_nociception_after0.94296386
110MP0002733_abnormal_thermal_nociception0.93802280
111MP0008875_abnormal_xenobiotic_pharmacok0.93057412
112MP0008007_abnormal_cellular_replicative0.92416783
113MP0009384_cardiac_valve_regurgitation0.92381694
114MP0000647_abnormal_sebaceous_gland0.92369670
115MP0003718_maternal_effect0.92093920
116MP0001666_abnormal_nutrient_absorption0.91803027
117MP0001533_abnormal_skeleton_physiology0.91787956
118MP0002229_neurodegeneration0.91499434
119MP0000465_gastrointestinal_hemorrhage0.91359510
120MP0003634_abnormal_glial_cell0.89745517
121MP0003950_abnormal_plasma_membrane0.89409347
122MP0001986_abnormal_taste_sensitivity0.89154931
123MP0003137_abnormal_impulse_conducting0.88611011
124MP0005508_abnormal_skeleton_morphology0.88552699
125MP0003136_yellow_coat_color0.88154485
126MP0009643_abnormal_urine_homeostasis0.87851971
127MP0002234_abnormal_pharynx_morphology0.87228032
128MP0002420_abnormal_adaptive_immunity0.86172090
129MP0009046_muscle_twitch0.85966082
130MP0009333_abnormal_splenocyte_physiolog0.85915183
131MP0002452_abnormal_antigen_presenting0.85353059
132MP0002572_abnormal_emotion/affect_behav0.85302395
133MP0002067_abnormal_sensory_capabilities0.85028614
134MP0004142_abnormal_muscle_tone0.84616648
135MP0002796_impaired_skin_barrier0.84277708
136MP0001819_abnormal_immune_cell0.84147354
137MP0001348_abnormal_lacrimal_gland0.83514364
138MP0002060_abnormal_skin_morphology0.83313294
139MP0005535_abnormal_body_temperature0.82730590
140MP0008469_abnormal_protein_level0.82724648
141MP0005551_abnormal_eye_electrophysiolog0.82574211
142MP0009745_abnormal_behavioral_response0.81520490
143MP0004272_abnormal_basement_membrane0.81021797
144MP0002075_abnormal_coat/hair_pigmentati0.80022273
145MP0005319_abnormal_enzyme/_coenzyme0.79997380
146MP0000470_abnormal_stomach_morphology0.79935406
147MP0002928_abnormal_bile_duct0.79915547
148MP0002063_abnormal_learning/memory/cond0.79731645
149* MP0002882_abnormal_neuron_morphology0.79680855
150MP0002066_abnormal_motor_capabilities/c0.79358096
151MP0002938_white_spotting0.79048687
152MP0001873_stomach_inflammation0.78331980
153MP0008260_abnormal_autophagy0.77828359
154MP0003566_abnormal_cell_adhesion0.77286177
155MP0008872_abnormal_physiological_respon0.76045764
156MP0009250_abnormal_appendicular_skeleto0.75401497
157MP0005408_hypopigmentation0.75304967
158MP0005083_abnormal_biliary_tract0.74859600
159MP0009765_abnormal_xenobiotic_induced0.74798960
160MP0001970_abnormal_pain_threshold0.74567587
161MP0003943_abnormal_hepatobiliary_system0.73950201
162MP0009697_abnormal_copulation0.73693940
163MP0009785_altered_susceptibility_to0.73626407
164MP0006072_abnormal_retinal_apoptosis0.73321464
165MP0000049_abnormal_middle_ear0.72166320
166MP0003942_abnormal_urinary_system0.71522624
167MP0005187_abnormal_penis_morphology0.71232447
168MP0003828_pulmonary_edema0.71114311
169* MP0002752_abnormal_somatic_nervous0.71072107
170MP0008789_abnormal_olfactory_epithelium0.70968796
171MP0000372_irregular_coat_pigmentation0.70347875
172MP0003638_abnormal_response/metabolism_0.69505823
173MP0004510_myositis0.69187902
174MP0000716_abnormal_immune_system0.68529718
175MP0003300_gastrointestinal_ulcer0.68153623
176MP0002751_abnormal_autonomic_nervous0.67978265
177MP0005636_abnormal_mineral_homeostasis0.65496576
178MP0005332_abnormal_amino_acid0.65334717
179MP0002277_abnormal_respiratory_mucosa0.64170218
180MP0002429_abnormal_blood_cell0.62479105

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)7.36442070
2Absent rod-and cone-mediated responses on ERG (HP:0007688)6.06896297
3Microvesicular hepatic steatosis (HP:0001414)5.58386608
4Abnormal rod and cone electroretinograms (HP:0008323)5.29680062
5Attenuation of retinal blood vessels (HP:0007843)4.85713935
6Premature rupture of membranes (HP:0001788)4.53988807
7Supranuclear gaze palsy (HP:0000605)4.40727662
8Bony spicule pigmentary retinopathy (HP:0007737)4.32964640
9Elevated erythrocyte sedimentation rate (HP:0003565)3.98008742
10Upper limb muscle weakness (HP:0003484)3.93618728
11Cerebellar dysplasia (HP:0007033)3.92522614
12* Decreased central vision (HP:0007663)3.89518795
13Neurofibrillary tangles (HP:0002185)3.72124451
14Type II lissencephaly (HP:0007260)3.56576786
15Absent/shortened dynein arms (HP:0200106)3.51731293
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.51731293
17Autoamputation (HP:0001218)3.47293759
18Acute hepatic failure (HP:0006554)3.46383220
19Retinal dysplasia (HP:0007973)3.39744679
20Wormian bones (HP:0002645)3.36142737
21Progressive neurologic deterioration (HP:0002344)3.30962246
22Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.20600110
23Chest pain (HP:0100749)3.16672388
24Peritonitis (HP:0002586)3.12010514
25Protrusio acetabuli (HP:0003179)3.05823830
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.05680277
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.05680277
28Sensorimotor neuropathy (HP:0007141)3.04829891
29Focal seizures (HP:0007359)3.01582232
30Recurrent corneal erosions (HP:0000495)3.00801784
31Bradycardia (HP:0001662)2.97588727
32Failure to thrive in infancy (HP:0001531)2.97363682
33Asymmetric septal hypertrophy (HP:0001670)2.89022744
34Hyporeflexia of lower limbs (HP:0002600)2.88748569
35Abnormal hemoglobin (HP:0011902)2.83893609
36Vertebral compression fractures (HP:0002953)2.83754157
37Fragile skin (HP:0001030)2.82931169
38Distal lower limb muscle weakness (HP:0009053)2.82059336
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82001433
40Abnormality of macular pigmentation (HP:0008002)2.81233160
41Palpebral edema (HP:0100540)2.80779147
42Constricted visual fields (HP:0001133)2.79946210
43Prolonged QT interval (HP:0001657)2.74096629
44Generalized tonic-clonic seizures (HP:0002069)2.71869526
45Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.71853360
46Abnormal pupillary function (HP:0007686)2.67677550
47Opisthotonus (HP:0002179)2.67263251
48Abolished electroretinogram (ERG) (HP:0000550)2.63860178
49Abnormality of cochlea (HP:0000375)2.63163908
50Atrophic scars (HP:0001075)2.61251043
51Abnormality of the corticospinal tract (HP:0002492)2.57534843
52Cerebral inclusion bodies (HP:0100314)2.53232902
53Bell-shaped thorax (HP:0001591)2.50598843
543-Methylglutaconic aciduria (HP:0003535)2.49764842
55Onion bulb formation (HP:0003383)2.49171760
56Abnormal respiratory motile cilium physiology (HP:0012261)2.46957910
57Hypoplastic pelvis (HP:0008839)2.43132647
58Myositis (HP:0100614)2.41636927
59Autoimmune thrombocytopenia (HP:0001973)2.40075424
60Clumsiness (HP:0002312)2.39704861
61Abnormal respiratory motile cilium morphology (HP:0005938)2.38974371
62Abnormal respiratory epithelium morphology (HP:0012253)2.38974371
63Soft skin (HP:0000977)2.35335878
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34257710
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34257710
66Abnormality of the peritoneum (HP:0002585)2.32584418
67Abnormal ciliary motility (HP:0012262)2.30996071
68Type 2 muscle fiber atrophy (HP:0003554)2.30415268
69Hyperglycinuria (HP:0003108)2.29989763
70Abnormal auditory evoked potentials (HP:0006958)2.27766863
71Hypoplasia of the iris (HP:0007676)2.24310127
72Focal motor seizures (HP:0011153)2.24094923
73Absence seizures (HP:0002121)2.21388877
74Mitral stenosis (HP:0001718)2.20596285
75Tubulointerstitial nephritis (HP:0001970)2.20022141
76Infantile muscular hypotonia (HP:0008947)2.19874825
77Cardiovascular calcification (HP:0011915)2.19380481
78Increased serum ferritin (HP:0003281)2.17765637
79Muscle fiber atrophy (HP:0100295)2.15938359
80Foot dorsiflexor weakness (HP:0009027)2.15901658
81Arterial tortuosity (HP:0005116)2.15660086
82Psychosis (HP:0000709)2.15596021
83Retinal atrophy (HP:0001105)2.15056894
84Abnormality of dentin (HP:0010299)2.13358447
85Vascular tortuosity (HP:0004948)2.13160391
86Muscle fiber splitting (HP:0003555)2.13041742
87Entropion (HP:0000621)2.12790099
88Enlarged epiphyses (HP:0010580)2.12307765
89Nasal polyposis (HP:0100582)2.12089588
90Gingival bleeding (HP:0000225)2.11901111
91Dialeptic seizures (HP:0011146)2.09302122
92Agammaglobulinemia (HP:0004432)2.08734084
93Lymphangioma (HP:0100764)2.07753487
94Distal lower limb amyotrophy (HP:0008944)2.05523771
95Tinnitus (HP:0000360)2.04713153
96Impulsivity (HP:0100710)2.04601484
97Increased intramyocellular lipid droplets (HP:0012240)2.04582609
98Keratoconjunctivitis sicca (HP:0001097)2.04388213
99Prolonged neonatal jaundice (HP:0006579)2.04295513
100Ileus (HP:0002595)2.04104594
101Xerostomia (HP:0000217)2.03762934
102Abnormality of transition element cation homeostasis (HP:0011030)2.02402451
103Congenital stationary night blindness (HP:0007642)2.00268372
104Epidermoid cyst (HP:0200040)2.00113875
105Severe visual impairment (HP:0001141)2.00050646
106Myokymia (HP:0002411)1.99842428
107Hypothermia (HP:0002045)1.98370139
108Abnormality of the pleura (HP:0002103)1.96899882
109Vascular calcification (HP:0004934)1.96585432
110Portal hypertension (HP:0001409)1.96325325
111Rapidly progressive (HP:0003678)1.94796511
112Ulnar deviation of the wrist (HP:0003049)1.93869662
113Myelomeningocele (HP:0002475)1.93762404
114Macular degeneration (HP:0000608)1.93503008
115Pustule (HP:0200039)1.93257956
116Steppage gait (HP:0003376)1.92571214
117Muscle stiffness (HP:0003552)1.91575283
118Keratoconjunctivitis (HP:0001096)1.90502274
119Progressive external ophthalmoplegia (HP:0000590)1.90360406
120Stomach cancer (HP:0012126)1.90165598
121Absent speech (HP:0001344)1.90160200
122Abnormality of dental color (HP:0011073)1.90103200
123Confusion (HP:0001289)1.89353341
124Easy fatigability (HP:0003388)1.87650617
125Cutaneous photosensitivity (HP:0000992)1.86949266
126Abnormality of the foot musculature (HP:0001436)1.86808348
127Decreased motor nerve conduction velocity (HP:0003431)1.86276434
128Dysostosis multiplex (HP:0000943)1.85715412
129Abnormality of iron homeostasis (HP:0011031)1.85612442
130Abnormality of the costochondral junction (HP:0000919)1.85356272
131Aplasia cutis congenita (HP:0001057)1.85334198
132Wrist flexion contracture (HP:0001239)1.84762678
133Symphalangism affecting the phalanges of the hand (HP:0009773)1.84736132
134Delayed epiphyseal ossification (HP:0002663)1.84358155
135Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.83926577
136Glucose intolerance (HP:0000833)1.83566716
137Cholecystitis (HP:0001082)1.83303790
138Abnormal gallbladder physiology (HP:0012438)1.83303790
139Anhidrosis (HP:0000970)1.83173441
140Recurrent sinusitis (HP:0011108)1.82591866
141Generalized myoclonic seizures (HP:0002123)1.81283094
142Atonic seizures (HP:0010819)1.80686809
143Abnormality of glycolipid metabolism (HP:0010969)1.80231407
144Abnormality of liposaccharide metabolism (HP:0010968)1.80231407
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.80231407
146Aortic dissection (HP:0002647)1.80023081
147Vacuolated lymphocytes (HP:0001922)1.79772373
148Knee flexion contracture (HP:0006380)1.79254348
149Amaurosis fugax (HP:0100576)1.78838495
150Episodic fever (HP:0001954)1.78715936
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.78693156
152Abnormality of the nasal mucosa (HP:0000433)1.78422375
153Abnormality of the hepatic vasculature (HP:0006707)1.78030486
154Increased cerebral lipofuscin (HP:0011813)1.77465321
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.77354808
156* Photophobia (HP:0000613)1.77117539
157Morphological abnormality of the inner ear (HP:0011390)1.76626743
158Chronic hepatic failure (HP:0100626)1.76237570
159Increased muscle lipid content (HP:0009058)1.75298493
160Leukocytosis (HP:0001974)1.74370318
161Mediastinal lymphadenopathy (HP:0100721)1.73080867
162Abnormality of the periventricular white matter (HP:0002518)1.71882638
163Abnormality of glycine metabolism (HP:0010895)1.71367846
164Abnormality of serine family amino acid metabolism (HP:0010894)1.71367846
165Prolonged partial thromboplastin time (HP:0003645)1.71023460
166Parakeratosis (HP:0001036)1.70960611
167Neoplasm of the heart (HP:0100544)1.70324139
168Autoimmune hemolytic anemia (HP:0001890)1.69517691
169Rhinitis (HP:0012384)1.69085580
170Delusions (HP:0000746)1.68995268
171Exotropia (HP:0000577)1.68746585
172Pulmonary infiltrates (HP:0002113)1.68287791
173Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67987208
174Elbow flexion contracture (HP:0002987)1.67601007
175Natal tooth (HP:0000695)1.67552169
176Asplenia (HP:0001746)1.66722111
177Abnormality of the musculature of the pelvis (HP:0001469)1.66548101
178Abnormality of the hip-girdle musculature (HP:0001445)1.66548101
179Aortic aneurysm (HP:0004942)1.64201422
180Pelvic girdle muscle weakness (HP:0003749)1.64115441
181Abnormality of cells of the erythroid lineage (HP:0012130)1.62253675
182Ventricular fibrillation (HP:0001663)1.61535017
183Septo-optic dysplasia (HP:0100842)1.60196093
184Aplasia involving bones of the upper limbs (HP:0009823)1.59537155
185Aplasia of the phalanges of the hand (HP:0009802)1.59537155
186Aplasia involving bones of the extremities (HP:0009825)1.59537155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB35.52915166
2PLK45.08293268
3BLK4.24294046
4TAOK34.12907893
5SIK23.41122545
6BMPR23.35649965
7VRK22.86703295
8PAK62.83504226
9INSRR2.62633219
10FLT32.58295513
11TESK12.55522238
12PLK22.52072168
13LATS22.47264418
14TLK12.40875059
15KIT2.32480383
16LIMK12.18578778
17DYRK1B2.12417812
18EPHB12.00431185
19ICK1.93840023
20FES1.93685172
21TRPM71.93507604
22TESK21.92223711
23CDK191.90441813
24IKBKB1.88658703
25EPHA41.82574734
26BCKDK1.80145199
27MARK21.78573836
28ARAF1.67542252
29DYRK31.64435956
30JAK31.63255099
31MAPKAPK31.62128925
32ZAK1.59954668
33MAP3K111.59777310
34NUAK11.59163428
35PKN11.47652302
36NTRK11.45235722
37PAK31.39925931
38PIM21.39302334
39EEF2K1.36251481
40FRK1.34486325
41STK391.34434633
42MAP2K21.34320707
43TNIK1.28659682
44IKBKE1.26881807
45DAPK11.24047344
46PIK3CG1.21672500
47SYK1.14234558
48ADRBK21.14153279
49DDR21.13047032
50MATK1.12618766
51DYRK21.10507104
52OXSR11.09907318
53PBK1.09834735
54DMPK1.08872186
55EIF2AK21.04015592
56MARK11.03581335
57CSF1R1.02844290
58TIE11.01553727
59ZAP701.01326084
60RPS6KA21.00667800
61MAP3K130.98261490
62FGR0.96524570
63RPS6KA60.96128566
64RPS6KC10.94888829
65RPS6KL10.94888829
66TBK10.94196998
67SIK10.93391299
68UHMK10.92878139
69MAP3K90.91325663
70MAP3K140.90924622
71RPS6KB20.90497119
72NME20.90097125
73MAP4K20.89285054
74TXK0.87084717
75WNK40.83342178
76CSNK1A1L0.83217752
77IRAK40.81889222
78CSNK1G30.81286129
79ABL20.81161324
80MAP4K10.80974017
81MAPK110.80844387
82NTRK20.79520692
83MAP3K60.79049252
84PRKCH0.78489535
85NTRK30.78057718
86BRAF0.77169766
87MAP2K40.75533014
88DAPK20.74990505
89GRK60.74952649
90BMPR1B0.73677279
91CDK140.73594821
92MAP3K40.73337181
93BTK0.72092413
94TYK20.71881404
95PTK2B0.71634740
96LCK0.71150028
97PAK20.69480357
98CDK150.68238655
99ROCK20.66104476
100SIK30.65602481
101LYN0.64221055
102TEC0.64208772
103CDK11A0.63560397
104CAMK2B0.63428140
105PRKCQ0.63353245
106MAP2K30.63183894
107TNK20.62768624
108ITK0.62670294
109CDK180.62195349
110PDK10.60798678
111FER0.60372241
112IRAK30.59732294
113TTN0.58390565
114HCK0.57464116
115MAPKAPK50.57409225
116CDK30.57399348
117PDPK10.57341328
118STK380.56825487
119VRK10.56778578
120PRKAA20.56451200
121MAPK130.56378424
122RAF10.56375775
123CAMK2D0.56250853
124RPS6KA10.55839467
125CHUK0.55696700
126SMG10.55417688
127GRK70.55359925
128PAK10.55264770
129CDK50.53974649
130MAP2K60.53873108
131CSNK1G20.53535503
132MAP2K70.52062127
133IRAK20.51219555
134BCR0.50295152
135CAMK2G0.49990431
136CDC42BPA0.49116606
137PRKD30.47232260
138ADRBK10.46146130
139MAPK10.45478869
140PNCK0.44942383
141CAMK2A0.44412153
142MAPK30.44386725
143MAPKAPK20.42392112
144PRKG10.42302681
145WNK10.41882342
146PRKCA0.41058133
147CSK0.40239304
148ERBB40.39915472
149JAK20.39468699
150NME10.39466245
151ROCK10.38197513
152PRKD10.37950761
153MYLK0.34633096
154MAPK150.34351681
155CLK10.34305186
156ERN10.30934220
157CSNK1G10.30645652
158KDR0.30330124
159MINK10.29738518
160MAP3K70.29479623
161ILK0.28341769
162PTK20.24761439
163CAMK1G0.23239879
164PRKCG0.22717745
165PRKCE0.22324635
166LRRK20.21872047
167DYRK1A0.21865359
168FYN0.21561972
169PRKACA0.19754004
170IRAK10.19013284
171GSK3A0.18962591
172MOS0.18793073
173GRK10.18726264

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.05118019
2Allograft rejection_Homo sapiens_hsa053303.90404190
3Graft-versus-host disease_Homo sapiens_hsa053323.74188942
4Autoimmune thyroid disease_Homo sapiens_hsa053203.69046836
5Linoleic acid metabolism_Homo sapiens_hsa005913.13229129
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10923170
7Type I diabetes mellitus_Homo sapiens_hsa049402.96932146
8Ether lipid metabolism_Homo sapiens_hsa005652.80807407
9Staphylococcus aureus infection_Homo sapiens_hsa051502.51633910
10Antigen processing and presentation_Homo sapiens_hsa046122.27511836
11One carbon pool by folate_Homo sapiens_hsa006702.24525238
12Axon guidance_Homo sapiens_hsa043602.22528291
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14540737
14Leishmaniasis_Homo sapiens_hsa051402.10006193
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07279199
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95420502
17Viral myocarditis_Homo sapiens_hsa054161.93719972
18Histidine metabolism_Homo sapiens_hsa003401.92338607
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88297533
20Other glycan degradation_Homo sapiens_hsa005111.83933294
21Cardiac muscle contraction_Homo sapiens_hsa042601.75034839
22Nitrogen metabolism_Homo sapiens_hsa009101.74934994
23Base excision repair_Homo sapiens_hsa034101.72899889
24Fatty acid biosynthesis_Homo sapiens_hsa000611.68600884
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62293079
26Peroxisome_Homo sapiens_hsa041461.60023740
27Fatty acid elongation_Homo sapiens_hsa000621.55870507
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55867313
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.55598567
30Fatty acid degradation_Homo sapiens_hsa000711.50744633
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49035217
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47172062
33Rheumatoid arthritis_Homo sapiens_hsa053231.43488055
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41589619
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40442822
36Homologous recombination_Homo sapiens_hsa034401.38727419
37Oxidative phosphorylation_Homo sapiens_hsa001901.38248417
38Caffeine metabolism_Homo sapiens_hsa002321.36473456
39* Olfactory transduction_Homo sapiens_hsa047401.35501243
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.35037250
41Nicotine addiction_Homo sapiens_hsa050331.34563347
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32424018
43Butanoate metabolism_Homo sapiens_hsa006501.31672074
44Pyruvate metabolism_Homo sapiens_hsa006201.31123978
45Fatty acid metabolism_Homo sapiens_hsa012121.30533238
46Dilated cardiomyopathy_Homo sapiens_hsa054141.29790606
47Arachidonic acid metabolism_Homo sapiens_hsa005901.29474272
48Steroid biosynthesis_Homo sapiens_hsa001001.25425874
49Glutamatergic synapse_Homo sapiens_hsa047241.21914725
50Ribosome_Homo sapiens_hsa030101.18788680
51Retinol metabolism_Homo sapiens_hsa008301.16005717
52Sphingolipid metabolism_Homo sapiens_hsa006001.13061262
53ECM-receptor interaction_Homo sapiens_hsa045121.10480047
54Alzheimers disease_Homo sapiens_hsa050101.10396507
55Lysosome_Homo sapiens_hsa041421.10350301
56Influenza A_Homo sapiens_hsa051641.09244372
57Phagosome_Homo sapiens_hsa041451.07842955
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07479848
59Sulfur metabolism_Homo sapiens_hsa009201.07356414
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07135479
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04034522
62Propanoate metabolism_Homo sapiens_hsa006401.03631540
63Folate biosynthesis_Homo sapiens_hsa007901.03612013
64Tuberculosis_Homo sapiens_hsa051521.03542674
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02621110
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01209656
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99145817
68PPAR signaling pathway_Homo sapiens_hsa033200.98772076
69Huntingtons disease_Homo sapiens_hsa050160.98349857
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.98287854
71Primary immunodeficiency_Homo sapiens_hsa053400.97509055
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96937856
73Starch and sucrose metabolism_Homo sapiens_hsa005000.96000769
74Serotonergic synapse_Homo sapiens_hsa047260.95728726
75Cocaine addiction_Homo sapiens_hsa050300.93187626
76Dorso-ventral axis formation_Homo sapiens_hsa043200.91743301
77Amphetamine addiction_Homo sapiens_hsa050310.91687277
78* Phototransduction_Homo sapiens_hsa047440.91284623
79Ras signaling pathway_Homo sapiens_hsa040140.90872353
80Adherens junction_Homo sapiens_hsa045200.89454683
81Fat digestion and absorption_Homo sapiens_hsa049750.89171580
82Toxoplasmosis_Homo sapiens_hsa051450.87870953
83Vibrio cholerae infection_Homo sapiens_hsa051100.84624843
84Vitamin B6 metabolism_Homo sapiens_hsa007500.83579175
85Arginine and proline metabolism_Homo sapiens_hsa003300.82937647
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82779151
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.81813956
88Systemic lupus erythematosus_Homo sapiens_hsa053220.81641309
89Hematopoietic cell lineage_Homo sapiens_hsa046400.81041391
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80406347
91Parkinsons disease_Homo sapiens_hsa050120.78082753
92Glutathione metabolism_Homo sapiens_hsa004800.77576540
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.76658894
94GABAergic synapse_Homo sapiens_hsa047270.76310141
95Renal cell carcinoma_Homo sapiens_hsa052110.76242960
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75494342
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75071106
98Herpes simplex infection_Homo sapiens_hsa051680.75023108
99Synaptic vesicle cycle_Homo sapiens_hsa047210.74199628
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.72458805
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71899416
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70890752
103Salivary secretion_Homo sapiens_hsa049700.69573345
104Focal adhesion_Homo sapiens_hsa045100.69219335
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69115400
106Morphine addiction_Homo sapiens_hsa050320.68900499
107Circadian entrainment_Homo sapiens_hsa047130.68335517
108Oxytocin signaling pathway_Homo sapiens_hsa049210.67987498
109Gap junction_Homo sapiens_hsa045400.67919368
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67396557
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67116249
112Complement and coagulation cascades_Homo sapiens_hsa046100.67078945
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66032489
114MAPK signaling pathway_Homo sapiens_hsa040100.64329057
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64080696
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.63324853
117Taste transduction_Homo sapiens_hsa047420.62258030
118beta-Alanine metabolism_Homo sapiens_hsa004100.59593610
119Vitamin digestion and absorption_Homo sapiens_hsa049770.59465901
120Wnt signaling pathway_Homo sapiens_hsa043100.58245963
121Pancreatic secretion_Homo sapiens_hsa049720.58150130
122Basal cell carcinoma_Homo sapiens_hsa052170.57504129
123B cell receptor signaling pathway_Homo sapiens_hsa046620.56966380
124ABC transporters_Homo sapiens_hsa020100.56200497
125Hedgehog signaling pathway_Homo sapiens_hsa043400.55218507
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54898579
127Osteoclast differentiation_Homo sapiens_hsa043800.54599232
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54055538
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53530408
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53292531
131Chemical carcinogenesis_Homo sapiens_hsa052040.52893214
132Long-term depression_Homo sapiens_hsa047300.51266317
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50102478
134Malaria_Homo sapiens_hsa051440.49894214
135Phenylalanine metabolism_Homo sapiens_hsa003600.49563621
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49151943
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49055784
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48945046
139Rap1 signaling pathway_Homo sapiens_hsa040150.47361966
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47336790
141Endocytosis_Homo sapiens_hsa041440.46699818
142Insulin secretion_Homo sapiens_hsa049110.45974575
143Glycerolipid metabolism_Homo sapiens_hsa005610.44309251
144Tryptophan metabolism_Homo sapiens_hsa003800.44304315
145Galactose metabolism_Homo sapiens_hsa000520.42787133
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.42343108
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42081196
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41788798
149Platelet activation_Homo sapiens_hsa046110.38514553
150Metabolic pathways_Homo sapiens_hsa011000.32721709
151Acute myeloid leukemia_Homo sapiens_hsa052210.30359306
152Legionellosis_Homo sapiens_hsa051340.29255725
153* Purine metabolism_Homo sapiens_hsa002300.27119019
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26699863
155Fanconi anemia pathway_Homo sapiens_hsa034600.23179582
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21652790
157Type II diabetes mellitus_Homo sapiens_hsa049300.19256087
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19094578
159Pertussis_Homo sapiens_hsa051330.18745790
160Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18630517
161Calcium signaling pathway_Homo sapiens_hsa040200.17925806
162Arginine biosynthesis_Homo sapiens_hsa002200.16804298

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