ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	7.49073382
2	rRNA methylation (GO:0031167)	6.27789341
3	high-density lipoprotein particle remodeling (GO:0034375)	6.26962462
4	adenosine receptor signaling pathway (GO:0001973)	5.93456244
5	purinergic nucleotide receptor signaling pathway (GO:0035590)	5.85122576
6	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	5.73624278
7	reverse cholesterol transport (GO:0043691)	5.63801780
8	rRNA modification (GO:0000154)	5.55747176
9	protein neddylation (GO:0045116)	5.43357865
10	meiotic chromosome segregation (GO:0045132)	5.40156355
11	protein carboxylation (GO:0018214)	5.37006448
12	peptidyl-glutamic acid carboxylation (GO:0017187)	5.37006448
13	cellular response to ATP (GO:0071318)	5.07017231
14	L-phenylalanine catabolic process (GO:0006559)	5.06586989
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.06586989
16	blood coagulation, intrinsic pathway (GO:0007597)	4.69752573
17	DNA strand renaturation (GO:0000733)	4.52186211
18	L-phenylalanine metabolic process (GO:0006558)	4.41368463
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.41368463
20	response to nitrosative stress (GO:0051409)	4.36108283
21	regulation of Golgi to plasma membrane protein transport (GO:0042996)	4.30705052
22	urea metabolic process (GO:0019627)	4.26924191
23	urea cycle (GO:0000050)	4.21193947
24	purinergic receptor signaling pathway (GO:0035587)	4.13292807
25	plasma lipoprotein particle remodeling (GO:0034369)	4.08424320
26	protein-lipid complex remodeling (GO:0034368)	4.08424320
27	macromolecular complex remodeling (GO:0034367)	4.08424320
28	heme transport (GO:0015886)	4.02031991
29	nitrogen cycle metabolic process (GO:0071941)	3.96637787
30	thrombin receptor signaling pathway (GO:0070493)	3.91386669
31	tyrosine metabolic process (GO:0006570)	3.89229556
32	GDP-mannose metabolic process (GO:0019673)	3.86721027
33	nucleotide transmembrane transport (GO:1901679)	3.86200527
34	nucleotide-sugar biosynthetic process (GO:0009226)	3.83507245
35	positive regulation of protein kinase C signaling (GO:0090037)	3.69633029
36	regulation of dopamine metabolic process (GO:0042053)	3.66604113
37	regulation of catecholamine metabolic process (GO:0042069)	3.66604113
38	purine ribonucleotide transport (GO:0015868)	3.64423120
39	regulation of triglyceride catabolic process (GO:0010896)	3.63228403
40	triglyceride catabolic process (GO:0019433)	3.59931820
41	very-low-density lipoprotein particle assembly (GO:0034379)	3.53881212
42	adenine nucleotide transport (GO:0051503)	3.44810501
43	behavioral response to nicotine (GO:0035095)	3.39231172
44	regulation of skeletal muscle contraction (GO:0014819)	3.34614543
45	acylglycerol catabolic process (GO:0046464)	3.31524901
46	neutral lipid catabolic process (GO:0046461)	3.31524901
47	low-density lipoprotein particle remodeling (GO:0034374)	3.30046511
48	glutathione derivative biosynthetic process (GO:1901687)	3.24688706
49	glutathione derivative metabolic process (GO:1901685)	3.24688706
50	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.20191486
51	triglyceride homeostasis (GO:0070328)	3.18871845
52	acylglycerol homeostasis (GO:0055090)	3.18871845
53	regulation of integrin-mediated signaling pathway (GO:2001044)	3.18727390
54	regulation of lipoprotein metabolic process (GO:0050746)	3.17077885
55	plasma lipoprotein particle organization (GO:0071827)	3.16733534
56	homocysteine metabolic process (GO:0050667)	3.11960038
57	L-serine metabolic process (GO:0006563)	3.11792886
58	diaphragm development (GO:0060539)	3.11060650
59	negative regulation of cell aging (GO:0090344)	3.10958952
60	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	3.09359773
61	iron coordination entity transport (GO:1901678)	3.08279448
62	citrulline biosynthetic process (GO:0019240)	3.07605824
63	nucleoside transmembrane transport (GO:1901642)	3.05334282
64	cellular glucuronidation (GO:0052695)	2.97923154
65	folic acid metabolic process (GO:0046655)	2.97441603
66	phospholipid efflux (GO:0033700)	2.95467638
67	plasma lipoprotein particle clearance (GO:0034381)	2.90773998
68	DNA replication checkpoint (GO:0000076)	2.90175517
69	purine nucleotide transport (GO:0015865)	2.89881556
70	vitamin transmembrane transport (GO:0035461)	2.89556789
71	glutathione metabolic process (GO:0006749)	2.87967884
72	protein-lipid complex subunit organization (GO:0071825)	2.87458803
73	positive regulation of systemic arterial blood pressure (GO:0003084)	2.86421580
74	bile acid and bile salt transport (GO:0015721)	2.85049582
75	lipoxygenase pathway (GO:0019372)	2.85002962
76	fibrinolysis (GO:0042730)	2.81662487
77	negative regulation of norepinephrine secretion (GO:0010700)	2.81518055
78	citrulline metabolic process (GO:0000052)	2.80263396
79	regulation of cholesterol esterification (GO:0010872)	2.79638808
80	aromatic amino acid family catabolic process (GO:0009074)	2.78197032
81	response to ATP (GO:0033198)	2.76446288
82	plasma lipoprotein particle assembly (GO:0034377)	2.72759169
83	microtubule depolymerization (GO:0007019)	2.72123865
84	cysteine metabolic process (GO:0006534)	2.71868783
85	peptidyl-glutamic acid modification (GO:0018200)	2.70441504
86	glucuronate metabolic process (GO:0019585)	2.69239052
87	uronic acid metabolic process (GO:0006063)	2.69239052
88	xenobiotic catabolic process (GO:0042178)	2.67294133
89	positive regulation of triglyceride lipase activity (GO:0061365)	2.66287202
90	positive regulation of lipoprotein lipase activity (GO:0051006)	2.66287202
91	negative regulation of heart rate (GO:0010459)	2.64668814
92	negative regulation of cholesterol transport (GO:0032375)	2.64361523
93	negative regulation of sterol transport (GO:0032372)	2.64361523
94	glycine metabolic process (GO:0006544)	2.63666843
95	positive regulation of hemostasis (GO:1900048)	2.63368641
96	positive regulation of blood coagulation (GO:0030194)	2.63368641
97	regulation of mitochondrial translation (GO:0070129)	2.62827923
98	fat-soluble vitamin biosynthetic process (GO:0042362)	2.60529623
99	dopamine transport (GO:0015872)	2.59984694
100	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.57559546

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.91903822
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.63930144
3	SRY_22984422_ChIP-ChIP_TESTIS_Rat	3.55439132
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.52116795
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.53085725
6	GATA1_22025678_ChIP-Seq_K562_Human	2.34110207
7	P68_20966046_ChIP-Seq_HELA_Human	2.33917938
8	ZNF263_19887448_ChIP-Seq_K562_Human	2.33768490
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.24826659
10	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.17962049
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.17114724
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.10752697
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.08584515
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.05406192
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03577117
16	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.94593283
17	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.90579016
18	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.87965686
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.80496442
20	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.76914875
21	SCL_19346495_ChIP-Seq_HPC-7_Human	1.72986776
22	E2F1_20622854_ChIP-Seq_HELA_Human	1.70393632
23	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.70282366
24	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.69819456
25	CTCF_21964334_Chip-Seq_Bcells_Human	1.66711995
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.65588548
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.62463656
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.62139959
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.61033736
30	BCOR_27268052_Chip-Seq_Bcells_Human	1.60296843
31	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.58145052
32	VDR_21846776_ChIP-Seq_THP-1_Human	1.53294175
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52872221
34	PHF8_20622854_ChIP-Seq_HELA_Human	1.52131206
35	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50708597
36	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.50584967
37	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.49379000
38	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.48505225
39	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.48287619
40	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.48187778
41	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.46919526
42	NCOR1_26117541_ChIP-Seq_K562_Human	1.45323495
43	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.45021133
44	CTCF_27219007_Chip-Seq_Bcells_Human	1.44007561
45	GATA1_19941826_ChIP-Seq_K562_Human	1.42819662
46	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.41478952
47	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40176018
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36126962
49	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.36036420
50	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.35708217
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34935548
52	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.34605700
53	HTT_18923047_ChIP-ChIP_STHdh_Human	1.34545727
54	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.33557761
55	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.31584485
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.31413939
57	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30895215
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29810312
59	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.29646822
60	SMC4_20622854_ChIP-Seq_HELA_Human	1.29471741
61	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.29159599
62	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.28970702
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.27754221
64	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.26311692
65	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.25188478
66	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.24268241
67	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.23171064
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.23109938
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.22307747
70	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.21409666
71	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.21263765
72	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.20794816
73	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.19483060
74	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.17359556
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.16601587
76	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.16027355
77	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.15625860
78	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.15174558
79	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.15015548
80	EWS_26573619_Chip-Seq_HEK293_Human	1.14304774
81	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.13295311
82	MAF_26560356_Chip-Seq_TH2_Human	1.12924752
83	ERG_20517297_ChIP-Seq_VCAP_Human	1.12216035
84	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08106743
85	SA1_27219007_Chip-Seq_Bcells_Human	1.07197056
86	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.07092061
87	ATF3_27146783_Chip-Seq_COLON_Human	1.05420943
88	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05367732
89	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05147629
90	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04572015
91	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.04032175
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02074295
93	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.01050890
94	GATA6_25053715_ChIP-Seq_YYC3_Human	0.99968522
95	RACK7_27058665_Chip-Seq_MCF-7_Human	0.99365832
96	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97869664
97	SOX2_21211035_ChIP-Seq_LN229_Human	0.96517431
98	MAF_26560356_Chip-Seq_TH1_Human	0.95141366
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.94949592
100	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.94439903

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.22610409
2	MP0001188_hyperpigmentation	4.34303347
3	MP0005171_absent_coat_pigmentation	4.31575163
4	MP0005464_abnormal_platelet_physiology	4.14697202
5	MP0001986_abnormal_taste_sensitivity	4.01079465
6	MP0005423_abnormal_somatic_nervous	3.92910332
7	MP0008875_abnormal_xenobiotic_pharmacok	3.92170595
8	MP0005083_abnormal_biliary_tract	3.76469678
9	MP0005174_abnormal_tail_pigmentation	3.73842027
10	MP0005409_darkened_coat_color	3.09868182
11	MP0005365_abnormal_bile_salt	2.64616152
12	MP0002139_abnormal_hepatobiliary_system	2.34021238
13	MP0005332_abnormal_amino_acid	2.27922574
14	MP0002736_abnormal_nociception_after	2.17491663
15	MP0005084_abnormal_gallbladder_morpholo	2.13382123
16	MP0001968_abnormal_touch/_nociception	2.08344166
17	MP0005085_abnormal_gallbladder_physiolo	2.06239034
18	MP0010386_abnormal_urinary_bladder	1.97663497
19	MP0004957_abnormal_blastocyst_morpholog	1.93603484
20	MP0001756_abnormal_urination	1.91592069
21	MP0003011_delayed_dark_adaptation	1.86422400
22	MP0010329_abnormal_lipoprotein_level	1.80434123
23	MP0005410_abnormal_fertilization	1.74519387
24	MP0009840_abnormal_foam_cell	1.71853236
25	MP0003111_abnormal_nucleus_morphology	1.71277866
26	MP0004019_abnormal_vitamin_homeostasis	1.67519151
27	MP0009697_abnormal_copulation	1.61500941
28	MP0003941_abnormal_skin_development	1.53221224
29	MP0002638_abnormal_pupillary_reflex	1.49888606
30	MP0002877_abnormal_melanocyte_morpholog	1.46337666
31	MP0005360_urolithiasis	1.39563742
32	MP0008004_abnormal_stomach_pH	1.36868548
33	MP0003878_abnormal_ear_physiology	1.36258566
34	MP0005377_hearing/vestibular/ear_phenot	1.36258566
35	MP0003453_abnormal_keratinocyte_physiol	1.34107684
36	MP0005501_abnormal_skin_physiology	1.31734889
37	MP0008872_abnormal_physiological_respon	1.28224795
38	MP0003186_abnormal_redox_activity	1.28037698
39	MP0010094_abnormal_chromosome_stability	1.27270065
40	MP0003718_maternal_effect	1.22135102
41	MP0002160_abnormal_reproductive_system	1.21487364
42	MP0003656_abnormal_erythrocyte_physiolo	1.21062256
43	MP0003806_abnormal_nucleotide_metabolis	1.18642905
44	MP0005551_abnormal_eye_electrophysiolog	1.13255333
45	MP0003195_calcinosis	1.12988775
46	MP0003638_abnormal_response/metabolism_	1.12606087
47	MP0005584_abnormal_enzyme/coenzyme_acti	1.11196329
48	MP0001661_extended_life_span	1.11172011
49	MP0004381_abnormal_hair_follicle	1.10249192
50	MP0006276_abnormal_autonomic_nervous	1.10159479
51	MP0003693_abnormal_embryo_hatching	1.05569592
52	MP0000230_abnormal_systemic_arterial	1.02790990
53	MP0005187_abnormal_penis_morphology	0.99924979
54	MP0000358_abnormal_cell_content/	0.98351350
55	MP0009643_abnormal_urine_homeostasis	0.96935142
56	MP0004130_abnormal_muscle_cell	0.95575930
57	MP0003566_abnormal_cell_adhesion	0.94935954
58	MP0004215_abnormal_myocardial_fiber	0.93991860
59	MP0002132_abnormal_respiratory_system	0.93367036
60	MP0000579_abnormal_nail_morphology	0.92671388
61	MP0008058_abnormal_DNA_repair	0.91925764
62	MP0005670_abnormal_white_adipose	0.91816853
63	MP0002138_abnormal_hepatobiliary_system	0.91306617
64	MP0001666_abnormal_nutrient_absorption	0.90764055
65	MP0009642_abnormal_blood_homeostasis	0.86814122
66	MP0000538_abnormal_urinary_bladder	0.85230030
67	MP0001919_abnormal_reproductive_system	0.84938571
68	MP0000015_abnormal_ear_pigmentation	0.83916703
69	MP0002735_abnormal_chemical_nociception	0.83807867
70	MP0003879_abnormal_hair_cell	0.82444260
71	MP0006036_abnormal_mitochondrial_physio	0.81506895
72	MP0000013_abnormal_adipose_tissue	0.80859009
73	MP0001529_abnormal_vocalization	0.80788234
74	MP0008932_abnormal_embryonic_tissue	0.80278376
75	MP0003252_abnormal_bile_duct	0.79921542
76	MP0001905_abnormal_dopamine_level	0.77181550
77	MP0003077_abnormal_cell_cycle	0.76875108
78	MP0001664_abnormal_digestion	0.75842891
79	MP0002019_abnormal_tumor_incidence	0.75320738
80	MP0005636_abnormal_mineral_homeostasis	0.74511660
81	MP0005058_abnormal_lysosome_morphology	0.74017312
82	MP0005499_abnormal_olfactory_system	0.73825205
83	MP0005394_taste/olfaction_phenotype	0.73825205
84	MP0002118_abnormal_lipid_homeostasis	0.71943062
85	MP0001765_abnormal_ion_homeostasis	0.71397902
86	MP0005666_abnormal_adipose_tissue	0.71303904
87	MP0000598_abnormal_liver_morphology	0.67852467
88	MP0000003_abnormal_adipose_tissue	0.67788286
89	MP0005389_reproductive_system_phenotype	0.65932192
90	MP0000343_altered_response_to	0.63119814
91	MP0004147_increased_porphyrin_level	0.62902375
92	MP0000609_abnormal_liver_physiology	0.61917437
93	MP0003315_abnormal_perineum_morphology	0.59013957
94	MP0008007_abnormal_cellular_replicative	0.55467405
95	MP0005375_adipose_tissue_phenotype	0.54446103
96	MP0006035_abnormal_mitochondrial_morpho	0.53799422
97	MP0008789_abnormal_olfactory_epithelium	0.53123051
98	MP0010771_integument_phenotype	0.52996610
99	MP0002136_abnormal_kidney_physiology	0.48622157
100	MP0002796_impaired_skin_barrier	0.47113714

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dyschromatopsia (HP:0007641)	7.34837082
2	Hyperlipoproteinemia (HP:0010980)	6.03416905
3	Menorrhagia (HP:0000132)	5.11868269
4	Prolonged bleeding time (HP:0003010)	4.72747875
5	Increased mean platelet volume (HP:0011877)	4.63788451
6	Petechiae (HP:0000967)	4.45914002
7	Testicular atrophy (HP:0000029)	4.32873916
8	Hypobetalipoproteinemia (HP:0003563)	4.31495902
9	Decreased central vision (HP:0007663)	4.25213394
10	Abnormal platelet volume (HP:0011876)	4.16241698
11	Annular pancreas (HP:0001734)	4.13665554
12	Joint hemorrhage (HP:0005261)	3.94181382
13	Abnormality of the common coagulation pathway (HP:0010990)	3.93989095
14	Abnormality of the intrinsic pathway (HP:0010989)	3.81045641
15	Purpura (HP:0000979)	3.80204783
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.76591342
17	Generalized aminoaciduria (HP:0002909)	3.67092610
18	Vaginal fistula (HP:0004320)	3.67080235
19	Prolonged partial thromboplastin time (HP:0003645)	3.66326666
20	Rib fusion (HP:0000902)	3.63455399
21	Male infertility (HP:0003251)	3.63295537
22	Epistaxis (HP:0000421)	3.52634788
23	Rectovaginal fistula (HP:0000143)	3.49908981
24	Rectal fistula (HP:0100590)	3.49908981
25	Facial hemangioma (HP:0000329)	3.44334935
26	Spontaneous abortion (HP:0005268)	3.33657009
27	Turricephaly (HP:0000262)	3.33088517
28	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.19724218
29	Ulnar bowing (HP:0003031)	3.14560216
30	Intestinal fistula (HP:0100819)	3.06677229
31	Impaired platelet aggregation (HP:0003540)	3.06163484
32	Abnormal platelet function (HP:0011869)	3.06163484
33	Acanthocytosis (HP:0001927)	3.06116006
34	Attenuation of retinal blood vessels (HP:0007843)	2.92840267
35	Hypophosphatemic rickets (HP:0004912)	2.92747308
36	Hyperalaninemia (HP:0003348)	2.87205497
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87205497
38	Abnormality of alanine metabolism (HP:0010916)	2.87205497
39	Abnormality of pyrimidine metabolism (HP:0004353)	2.84528381
40	Abnormality of serum amino acid levels (HP:0003112)	2.81323494
41	Congenital stationary night blindness (HP:0007642)	2.68616096
42	Poikilocytosis (HP:0004447)	2.66766687
43	Squamous cell carcinoma (HP:0002860)	2.62359235
44	Reduced antithrombin III activity (HP:0001976)	2.60489663
45	Choanal stenosis (HP:0000452)	2.59823367
46	Bony spicule pigmentary retinopathy (HP:0007737)	2.53360713
47	Gingival bleeding (HP:0000225)	2.52128224
48	Megaloblastic anemia (HP:0001889)	2.50158139
49	Xanthomatosis (HP:0000991)	2.45609388
50	Paralysis (HP:0003470)	2.45282178
51	Hyperglycinuria (HP:0003108)	2.41730758
52	Renal Fanconi syndrome (HP:0001994)	2.38574329
53	Hypolipoproteinemia (HP:0010981)	2.35594200
54	Poikiloderma (HP:0001029)	2.34802651
55	Abnormality of methionine metabolism (HP:0010901)	2.34754350
56	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.25284900
57	Birth length less than 3rd percentile (HP:0003561)	2.23246547
58	Nausea (HP:0002018)	2.20424754
59	Atrioventricular block (HP:0001678)	2.19754238
60	Abnormal lung lobation (HP:0002101)	2.16669512
61	Rickets (HP:0002748)	2.16089520
62	Abnormality of the costochondral junction (HP:0000919)	2.13076346
63	Capillary hemangiomas (HP:0005306)	2.11001235
64	Popliteal pterygium (HP:0009756)	2.09758656
65	Hyperglycinemia (HP:0002154)	2.08204236
66	Abnormality of iron homeostasis (HP:0011031)	2.07523702
67	Cholelithiasis (HP:0001081)	2.07469154
68	Abnormal pupillary function (HP:0007686)	2.06484031
69	Aplasia of the musculature (HP:0100854)	2.05372557
70	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.04494975
71	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.03214880
72	Coronal craniosynostosis (HP:0004440)	2.00592102
73	Abnormality of glycine metabolism (HP:0010895)	1.99844816
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99844816
75	Abnormal drinking behavior (HP:0030082)	1.99322795
76	Polydipsia (HP:0001959)	1.99322795
77	Increased number of teeth (HP:0011069)	1.98322882
78	Facial diplegia (HP:0001349)	1.97732879
79	Amniotic constriction ring (HP:0009775)	1.95201220
80	Abnormality of placental membranes (HP:0011409)	1.95201220
81	Absent thumb (HP:0009777)	1.94960046
82	Hypoplasia of the uterus (HP:0000013)	1.94133573
83	Muscle fiber atrophy (HP:0100295)	1.92398553
84	Vascular calcification (HP:0004934)	1.90965563
85	Hemorrhage of the eye (HP:0011885)	1.89911857
86	Increased serum ferritin (HP:0003281)	1.88957220
87	Breast aplasia (HP:0100783)	1.87586000
88	Pendular nystagmus (HP:0012043)	1.87415847
89	Infertility (HP:0000789)	1.87236807
90	Abnormal gallbladder morphology (HP:0012437)	1.87140585
91	Hypercholesterolemia (HP:0003124)	1.85069023
92	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.84490740
93	Bilateral microphthalmos (HP:0007633)	1.84071969
94	Chorioretinal atrophy (HP:0000533)	1.82818325
95	Type 2 muscle fiber atrophy (HP:0003554)	1.82288041
96	Abnormality of homocysteine metabolism (HP:0010919)	1.82162804
97	Homocystinuria (HP:0002156)	1.82162804
98	Choroideremia (HP:0001139)	1.80585886
99	Lipid accumulation in hepatocytes (HP:0006561)	1.76869902
100	Abnormality of transition element cation homeostasis (HP:0011030)	1.75119920

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.60129146
2	PDK2	3.59590089
3	PBK	3.54083665
4	MAPK15	3.46395180
5	MUSK	3.42503855
6	WNK4	3.28443576
7	PIK3CG	3.19485470
8	TESK2	3.15512255
9	BMX	2.88374525
10	ACVR1B	2.81670070
11	STK16	2.68728398
12	EIF2AK1	2.59287916
13	GRK6	2.39382452
14	CDC7	2.09976399
15	BMPR1B	1.97510836
16	MST1R	1.90549789
17	NUAK1	1.90500711
18	TLK1	1.79357474
19	MYLK	1.60927376
20	TNIK	1.57701897
21	BLK	1.54572555
22	PRKG2	1.43262407
23	ZAK	1.36508671
24	ZAP70	1.35157897
25	NME1	1.33658389
26	VRK2	1.32866759
27	GRK5	1.23719502
28	MKNK1	1.21540274
29	ILK	1.16585919
30	DYRK3	1.13432833
31	TEC	1.09378161
32	NEK2	1.08810588
33	STK3	1.08033606
34	ADRBK1	1.01374273
35	NEK9	0.98432786
36	VRK1	0.95362159
37	BUB1	0.89252129
38	MET	0.89083802
39	DYRK2	0.87880482
40	TTK	0.87134303
41	BTK	0.86941393
42	SIK1	0.86501388
43	PLK1	0.84865862
44	INSRR	0.81733916
45	PAK1	0.81438166
46	ARAF	0.80770566
47	ADRBK2	0.77300103
48	PIM2	0.74578297
49	PLK3	0.72032842
50	DAPK1	0.70676201
51	MAP3K12	0.69178503
52	GRK1	0.68905836
53	PTK2B	0.66875153
54	MAPKAPK3	0.66431992
55	OXSR1	0.63186817
56	MAPK12	0.63070391
57	AURKA	0.63011484
58	STK39	0.62815857
59	IRAK2	0.61977021
60	CDK7	0.59569118
61	WNK3	0.58777998
62	PDPK1	0.57313122
63	MAP2K3	0.57050543
64	MAP2K4	0.55417458
65	TRIM28	0.54675661
66	SYK	0.54283664
67	MAPK11	0.53458715
68	MAPKAPK5	0.52142695
69	RPS6KA5	0.49843063
70	RAF1	0.49027345
71	ATR	0.47706988
72	LMTK2	0.46254437
73	TGFBR1	0.45235680
74	CHEK2	0.43179959
75	MKNK2	0.43033954
76	CDK6	0.42992758
77	NME2	0.42498579
78	PRKACG	0.42456096
79	MAP2K6	0.40399437
80	MAP3K5	0.39249824
81	PRKCG	0.38982510
82	RPS6KA4	0.38640071
83	PRKD1	0.38308977
84	BRSK2	0.37630942
85	RPS6KB2	0.35201500
86	DAPK3	0.34326712
87	IRAK1	0.33141046
88	NLK	0.31718269
89	IKBKB	0.31574449
90	CSNK1D	0.29963774
91	AKT2	0.29155052
92	CCNB1	0.28815477
93	CDK3	0.28796932
94	MAP2K1	0.27342145
95	CSNK2A1	0.27164388
96	PRKCE	0.26719004
97	CSF1R	0.26066408
98	PRKCA	0.24188562
99	FER	0.22312957
100	PRKACA	0.21309444

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.87688677
2	Caffeine metabolism_Homo sapiens_hsa00232	3.76144916
3	Sulfur relay system_Homo sapiens_hsa04122	2.70077008
4	Chemical carcinogenesis_Homo sapiens_hsa05204	2.60632629
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.56240382
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.55880907
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.50621025
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.49585820
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.39442849
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.31419817
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.27165860
12	Retinol metabolism_Homo sapiens_hsa00830	2.12079478
13	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.97418816
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.85614832
15	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.83901186
16	Mismatch repair_Homo sapiens_hsa03430	1.77206422
17	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.70906544
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.70304684
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.66079009
20	Glutathione metabolism_Homo sapiens_hsa00480	1.65833651
21	Phenylalanine metabolism_Homo sapiens_hsa00360	1.61643346
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.57148097
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.53834512
24	One carbon pool by folate_Homo sapiens_hsa00670	1.52269464
25	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.50060996
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.49801851
27	Platelet activation_Homo sapiens_hsa04611	1.46314452
28	Fatty acid degradation_Homo sapiens_hsa00071	1.46107729
29	Complement and coagulation cascades_Homo sapiens_hsa04610	1.46061024
30	Galactose metabolism_Homo sapiens_hsa00052	1.45484747
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.45286978
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.43265500
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.42965795
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.41893387
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.37350910
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35931942
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.31529413
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29106013
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27794136
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.26964538
41	Pentose phosphate pathway_Homo sapiens_hsa00030	1.25129347
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.20928139
43	Bile secretion_Homo sapiens_hsa04976	1.20793318
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.14256582
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14074790
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.04120159
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01861131
48	Homologous recombination_Homo sapiens_hsa03440	0.98348175
49	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98081794
50	DNA replication_Homo sapiens_hsa03030	0.96280882
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95276697
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95045735
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.88718320
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87271628
55	Steroid biosynthesis_Homo sapiens_hsa00100	0.85963174
56	Histidine metabolism_Homo sapiens_hsa00340	0.85013926
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.84252086
58	PPAR signaling pathway_Homo sapiens_hsa03320	0.84062981
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.82749018
60	RNA polymerase_Homo sapiens_hsa03020	0.80226014
61	Butanoate metabolism_Homo sapiens_hsa00650	0.80223930
62	Base excision repair_Homo sapiens_hsa03410	0.78155232
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.77144193
64	Purine metabolism_Homo sapiens_hsa00230	0.76771679
65	Carbon metabolism_Homo sapiens_hsa01200	0.76250547
66	Metabolic pathways_Homo sapiens_hsa01100	0.75332608
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.74969887
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74485208
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73578331
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.72025600
71	ABC transporters_Homo sapiens_hsa02010	0.70396972
72	Peroxisome_Homo sapiens_hsa04146	0.70111879
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68497883
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66407017
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63051573
76	Taste transduction_Homo sapiens_hsa04742	0.61821636
77	Fatty acid elongation_Homo sapiens_hsa00062	0.55463228
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.55277855
79	ECM-receptor interaction_Homo sapiens_hsa04512	0.52220782
80	Circadian rhythm_Homo sapiens_hsa04710	0.51173249
81	Parkinsons disease_Homo sapiens_hsa05012	0.46851841
82	Cell cycle_Homo sapiens_hsa04110	0.45670204
83	Lysine degradation_Homo sapiens_hsa00310	0.44606927
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38758944
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38611316
86	Serotonergic synapse_Homo sapiens_hsa04726	0.36888015
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36722137
88	Gap junction_Homo sapiens_hsa04540	0.35578632
89	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.33608664
90	Ribosome_Homo sapiens_hsa03010	0.32058461
91	Mineral absorption_Homo sapiens_hsa04978	0.30300910
92	Oxidative phosphorylation_Homo sapiens_hsa00190	0.29758174
93	Nicotine addiction_Homo sapiens_hsa05033	0.28398889
94	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.28249403
95	Alcoholism_Homo sapiens_hsa05034	0.27998038
96	Huntingtons disease_Homo sapiens_hsa05016	0.27274780
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27103109
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.25411827
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.24905359
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24837219

GUCY2EP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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