GUCY2F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)9.90938611
2eye photoreceptor cell development (GO:0042462)9.83772013
3* phototransduction, visible light (GO:0007603)9.27253957
4* phototransduction (GO:0007602)9.19894647
5* detection of visible light (GO:0009584)8.87035825
6* detection of light stimulus (GO:0009583)8.66881079
7retinal rod cell development (GO:0046548)8.40920383
8positive regulation of guanylate cyclase activity (GO:0031284)8.40464859
9regulation of protein polyubiquitination (GO:1902914)8.34454338
10gamma-aminobutyric acid transport (GO:0015812)7.79309044
11regulation of guanylate cyclase activity (GO:0031282)7.55728743
12* visual perception (GO:0007601)7.41615895
13* sensory perception of light stimulus (GO:0050953)7.33371115
14regulation of hippo signaling (GO:0035330)7.24180669
15GMP metabolic process (GO:0046037)7.16892163
16positive regulation of cGMP biosynthetic process (GO:0030828)6.51052849
17regulation of cGMP metabolic process (GO:0030823)6.42199104
18* cellular response to light stimulus (GO:0071482)6.22799870
19protein retention in ER lumen (GO:0006621)6.21700313
20regulation of cGMP biosynthetic process (GO:0030826)6.09792557
21* detection of external stimulus (GO:0009581)6.01734405
22* detection of abiotic stimulus (GO:0009582)5.88826195
23ganglion development (GO:0061548)5.86259971
24positive regulation of cGMP metabolic process (GO:0030825)5.73427699
25left/right pattern formation (GO:0060972)5.71373717
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.49057405
27photoreceptor cell differentiation (GO:0046530)5.42590325
28eye photoreceptor cell differentiation (GO:0001754)5.42590325
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.38176031
30retina development in camera-type eye (GO:0060041)5.25398752
31positive regulation of growth hormone secretion (GO:0060124)5.21747986
32transmission of nerve impulse (GO:0019226)5.15520828
33detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.94747711
34endocrine hormone secretion (GO:0060986)4.93181521
35regulation of cilium movement (GO:0003352)4.70497012
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67970598
37peristalsis (GO:0030432)4.63188580
38mitotic sister chromatid cohesion (GO:0007064)4.62793903
39chaperone-mediated protein transport (GO:0072321)4.60152516
40G-protein coupled receptor internalization (GO:0002031)4.52339858
41epithelial cilium movement (GO:0003351)4.44550612
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.39630136
43cell migration in hindbrain (GO:0021535)4.38206027
44nonmotile primary cilium assembly (GO:0035058)4.27225105
45cilium movement (GO:0003341)4.21366076
46norepinephrine metabolic process (GO:0042415)4.19341198
47* cellular response to radiation (GO:0071478)4.17392417
48adaptation of signaling pathway (GO:0023058)4.14294277
49estrogen biosynthetic process (GO:0006703)4.05519885
50endocardial cushion morphogenesis (GO:0003203)3.97372228
51ATP synthesis coupled proton transport (GO:0015986)3.96047012
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96047012
53mating behavior (GO:0007617)3.93905983
54regulation of microtubule-based movement (GO:0060632)3.92959046
55synaptic transmission, cholinergic (GO:0007271)3.89010434
56type B pancreatic cell development (GO:0003323)3.81629317
57sequestering of actin monomers (GO:0042989)3.72852075
58cell morphogenesis involved in neuron differentiation (GO:0048667)3.72797764
59striatum development (GO:0021756)3.72474249
60copper ion homeostasis (GO:0055070)3.70649073
61detection of bacterium (GO:0016045)3.70528386
62parturition (GO:0007567)3.70488170
63regulation of clathrin-mediated endocytosis (GO:2000369)3.69922249
64* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.68690082
65regulation of voltage-gated calcium channel activity (GO:1901385)3.68570687
66positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.68367975
67behavioral response to nicotine (GO:0035095)3.61171181
68regulation of growth hormone secretion (GO:0060123)3.58526337
69* sensory perception (GO:0007600)3.57160593
70mechanosensory behavior (GO:0007638)3.55168984
71positive regulation of gastrulation (GO:2000543)3.53887093
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44817084
73locomotory exploration behavior (GO:0035641)3.40952122
74* response to light stimulus (GO:0009416)3.39492113
75retina layer formation (GO:0010842)3.38062550
76axonemal dynein complex assembly (GO:0070286)3.37009889
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36983924
78Notch signaling involved in heart development (GO:0061314)3.33733013
79forebrain neuron differentiation (GO:0021879)3.32631549
80positive regulation of sodium ion transmembrane transport (GO:1902307)3.31855394
81peptidyl-glutamic acid carboxylation (GO:0017187)3.30504019
82protein carboxylation (GO:0018214)3.30504019
83grooming behavior (GO:0007625)3.30051875
84positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.25619156
85response to histamine (GO:0034776)3.23863779
86negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22216378
87regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21976387
88thyroid hormone generation (GO:0006590)3.19771367
89cilium or flagellum-dependent cell motility (GO:0001539)3.19137983
90behavioral response to ethanol (GO:0048149)3.17565543
91axon extension (GO:0048675)3.15498683
92regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.14745876
93neuron development (GO:0048666)3.13888747
94protein localization to microtubule (GO:0035372)3.12215179
95cochlea morphogenesis (GO:0090103)3.11969545
96detection of other organism (GO:0098543)3.11420310
97neuromuscular synaptic transmission (GO:0007274)3.11092927
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.97425541
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97348455
100positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.94920134
101positive regulation of neurotransmitter transport (GO:0051590)2.93515736
102negative regulation of axon guidance (GO:1902668)2.93014128
103mesenchyme morphogenesis (GO:0072132)2.92373431
104CDP-diacylglycerol biosynthetic process (GO:0016024)2.91478452
105regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90883138
106regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90883138
107auditory behavior (GO:0031223)2.90141706
108prepulse inhibition (GO:0060134)2.89738944
109outer ear morphogenesis (GO:0042473)2.89390021
110membrane hyperpolarization (GO:0060081)2.88884189
111glomerulus development (GO:0032835)2.88121415
112regulation of cardioblast proliferation (GO:0003264)2.86862520
113regulation of secondary heart field cardioblast proliferation (GO:0003266)2.86862520
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84707509
115chemosensory behavior (GO:0007635)2.84328177
116phospholipid translocation (GO:0045332)2.83811337
117lipid translocation (GO:0034204)2.83811337
118artery smooth muscle contraction (GO:0014824)2.83722089
119protein-cofactor linkage (GO:0018065)2.82685403
120positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.82451905
121retinoid metabolic process (GO:0001523)2.81590301
122convergent extension (GO:0060026)2.79768678
123positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79257596
124negative regulation of cell aging (GO:0090344)2.78762769
125regulation of transcription regulatory region DNA binding (GO:2000677)2.78758255
126positive regulation of amino acid transport (GO:0051957)2.77063477
127regulation of synaptic vesicle exocytosis (GO:2000300)2.76831975
128response to inactivity (GO:0014854)2.75955810
129cellular potassium ion homeostasis (GO:0030007)2.75703669
130GTP biosynthetic process (GO:0006183)2.74692203
131neurofilament cytoskeleton organization (GO:0060052)2.74664669
132short-term memory (GO:0007614)2.71709332
133substrate-independent telencephalic tangential migration (GO:0021826)2.70536350
134substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70536350
135regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.70380541
136glandular epithelial cell differentiation (GO:0002067)2.70172284
137negative regulation of membrane potential (GO:0045837)2.70142855
138prenylation (GO:0097354)2.68799903
139protein prenylation (GO:0018342)2.68799903
140detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.68248674
141thyroid gland development (GO:0030878)2.68144991
142somite development (GO:0061053)2.67873274
143actin filament depolymerization (GO:0030042)2.67788981
144magnesium ion transport (GO:0015693)2.67715422
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66689414
146synaptic vesicle maturation (GO:0016188)2.65907023
147ovulation cycle (GO:0042698)2.65667785
148cell-cell junction maintenance (GO:0045217)2.65050128
149sodium-independent organic anion transport (GO:0043252)2.64608075
150potassium ion import (GO:0010107)2.64375766
151negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64332040
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.64251059
153central nervous system projection neuron axonogenesis (GO:0021952)2.63327404
154negative regulation of histone methylation (GO:0031061)2.62633177
155macroautophagy (GO:0016236)2.62433273
156positive regulation of ERBB signaling pathway (GO:1901186)2.61926625
157negative regulation of microtubule polymerization (GO:0031115)2.61417647
158protein localization to synapse (GO:0035418)2.60143695
159diterpenoid metabolic process (GO:0016101)2.58447028
160positive regulation of fatty acid beta-oxidation (GO:0032000)2.57214117
161thyroid hormone metabolic process (GO:0042403)2.56431894
162retinal ganglion cell axon guidance (GO:0031290)2.55161996
163dicarboxylic acid catabolic process (GO:0043649)2.53968459
164regulation of penile erection (GO:0060405)2.53778980
165CDP-diacylglycerol metabolic process (GO:0046341)2.53014329
166peptidyl-glutamic acid modification (GO:0018200)2.50321077
167viral transcription (GO:0019083)2.50179292
168adult walking behavior (GO:0007628)2.49223387
169innervation (GO:0060384)2.48347715
170bone trabecula formation (GO:0060346)2.47073870
171negative regulation of receptor-mediated endocytosis (GO:0048261)2.46643326
172neuron projection extension (GO:1990138)2.46185794
173dopamine receptor signaling pathway (GO:0007212)2.45469411
174intraciliary transport (GO:0042073)2.45355453
175tonic smooth muscle contraction (GO:0014820)2.45088659
176cAMP catabolic process (GO:0006198)2.45060515
177axonal fasciculation (GO:0007413)2.44956863
178detection of chemical stimulus involved in sensory perception (GO:0050907)2.44583570
179righting reflex (GO:0060013)2.44044720
180axoneme assembly (GO:0035082)2.41333288
181histone H3-K9 demethylation (GO:0033169)2.41198745
182* response to radiation (GO:0009314)2.40748779
183regulation of DNA endoreduplication (GO:0032875)2.35239596
184retina homeostasis (GO:0001895)2.35167641
185terpenoid metabolic process (GO:0006721)2.34714500
186behavioral response to cocaine (GO:0048148)2.33695559
187neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.33567158
188startle response (GO:0001964)2.29870832
189* regulation of rhodopsin mediated signaling pathway (GO:0022400)15.4502508
190* rhodopsin mediated signaling pathway (GO:0016056)15.1575071
191retinal cone cell development (GO:0046549)14.8755602
192photoreceptor cell maintenance (GO:0045494)10.3052580
193photoreceptor cell development (GO:0042461)10.2304556
194detection of light stimulus involved in visual perception (GO:0050908)10.2075429
195detection of light stimulus involved in sensory perception (GO:0050962)10.2075429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.26279876
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.15224367
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33709108
4GBX2_23144817_ChIP-Seq_PC3_Human3.29182147
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.18701177
6E2F7_22180533_ChIP-Seq_HELA_Human3.00324541
7TAF15_26573619_Chip-Seq_HEK293_Human2.90651076
8CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.85924244
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.59642830
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.53013400
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.46593610
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37902910
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.32425167
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.30370234
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13856737
16BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.11434195
17RNF2_27304074_Chip-Seq_NSC_Mouse2.09162906
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02216226
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.01078213
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99738950
21FUS_26573619_Chip-Seq_HEK293_Human1.89289278
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89065722
23AR_21572438_ChIP-Seq_LNCaP_Human1.81382068
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79511819
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79218951
26LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78479124
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.76228521
28ZNF263_19887448_ChIP-Seq_K562_Human1.72179666
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71933266
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.69394023
31ZNF274_21170338_ChIP-Seq_K562_Hela1.66781415
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65514384
33SMAD4_21799915_ChIP-Seq_A2780_Human1.64421321
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.64075319
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.63277735
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61791768
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60466119
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59695334
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58128455
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.56476015
41STAT3_23295773_ChIP-Seq_U87_Human1.54912358
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.53225333
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52708858
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50341359
45IGF1R_20145208_ChIP-Seq_DFB_Human1.49759903
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.48314422
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46745920
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46508506
49REST_21632747_ChIP-Seq_MESCs_Mouse1.46463887
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46008475
51EWS_26573619_Chip-Seq_HEK293_Human1.45210422
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45142038
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45077191
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45026688
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43193478
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.42500051
57E2F1_18555785_Chip-Seq_ESCs_Mouse1.42442814
58TP53_16413492_ChIP-PET_HCT116_Human1.41951586
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40837699
60AR_19668381_ChIP-Seq_PC3_Human1.40819069
61EZH2_22144423_ChIP-Seq_EOC_Human1.40763185
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.37491099
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37374833
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36918843
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.35760810
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35675387
67* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34782709
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.33393371
69CTCF_18555785_Chip-Seq_ESCs_Mouse1.32189391
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.32171786
71* P300_19829295_ChIP-Seq_ESCs_Human1.31095018
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30709856
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30231748
74P300_18555785_Chip-Seq_ESCs_Mouse1.30189926
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.29680074
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29431549
77FLI1_27457419_Chip-Seq_LIVER_Mouse1.28364544
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.27292709
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.27159246
80ER_23166858_ChIP-Seq_MCF-7_Human1.26776593
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.26759467
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26540989
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26258138
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24779754
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.24271475
86DROSHA_22980978_ChIP-Seq_HELA_Human1.23555805
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23137798
88BCAT_22108803_ChIP-Seq_LS180_Human1.23107760
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.21676620
90ZFX_18555785_Chip-Seq_ESCs_Mouse1.20257547
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18350408
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18341050
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17781931
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17745820
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17630017
96SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17617102
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17612668
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.17298956
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.17221475
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16774804
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16559858
102TCF4_23295773_ChIP-Seq_U87_Human1.16499628
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15834087
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15745517
105CBP_21632823_ChIP-Seq_H3396_Human1.15602923
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14496374
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.14093842
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13126353
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12865829
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12138560
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.11802021
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.11302783
113JUN_21703547_ChIP-Seq_K562_Human1.11139009
114TP53_18474530_ChIP-ChIP_U2OS_Human1.10940689
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10931705
116VDR_22108803_ChIP-Seq_LS180_Human1.10689952
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10294012
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10294012
119TBL1_22424771_ChIP-Seq_293T_Human1.09939683
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.09782971
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08050464
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08038911
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07330468
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.06018985
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05962027
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05124243
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03858122
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03765171
129RING1B_27294783_Chip-Seq_NPCs_Mouse1.02928284
130* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02063665
131P53_22387025_ChIP-Seq_ESCs_Mouse1.01685491
132ESR1_20079471_ChIP-ChIP_T-47D_Human1.01340767
133EZH2_18974828_ChIP-Seq_MESCs_Mouse1.00923838
134RNF2_18974828_ChIP-Seq_MESCs_Mouse1.00923838
135GF1B_26923725_Chip-Seq_HPCs_Mouse1.00462944
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00461889
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00113286
138AR_25329375_ChIP-Seq_VCAP_Human0.99671077
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.99466906
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99369167
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.98888802
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96701246
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96491685
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96288571
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95045347
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94839178
147TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94781578
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.94623282
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.94525139
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94204751
151PU1_27457419_Chip-Seq_LIVER_Mouse0.94188657
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93565574
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93475209
154TRIM28_21343339_ChIP-Seq_HEK293_Human0.90198972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.09914304
2MP0002822_catalepsy8.22347212
3MP0005253_abnormal_eye_physiology6.55233931
4MP0006072_abnormal_retinal_apoptosis6.03170815
5MP0003950_abnormal_plasma_membrane3.94633584
6MP0000566_synostosis3.69522656
7MP0005195_abnormal_posterior_eye3.46382976
8MP0002090_abnormal_vision3.37245760
9MP0001324_abnormal_eye_pigmentation3.29223979
10MP0000372_irregular_coat_pigmentation3.15191122
11MP0005391_vision/eye_phenotype3.12561561
12MP0001529_abnormal_vocalization2.83552117
13MP0005187_abnormal_penis_morphology2.82941885
14MP0002638_abnormal_pupillary_reflex2.73520406
15MP0002229_neurodegeneration2.54256035
16MP0002876_abnormal_thyroid_physiology2.49375372
17MP0002938_white_spotting2.46917825
18MP0004133_heterotaxia2.39411609
19MP0001440_abnormal_grooming_behavior2.25906019
20MP0003315_abnormal_perineum_morphology2.13395203
21MP0005423_abnormal_somatic_nervous2.02163811
22MP0003011_delayed_dark_adaptation10.0307053
23MP0003880_abnormal_central_pattern1.93634414
24MP0003119_abnormal_digestive_system1.75177662
25MP0002752_abnormal_somatic_nervous1.73887647
26MP0001502_abnormal_circadian_rhythm1.69011071
27MP0003283_abnormal_digestive_organ1.59320063
28MP0001905_abnormal_dopamine_level1.56420890
29MP0001764_abnormal_homeostasis1.55960690
30MP0002233_abnormal_nose_morphology1.46613384
31MP0010386_abnormal_urinary_bladder1.45385526
32MP0000631_abnormal_neuroendocrine_gland1.45006832
33MP0001485_abnormal_pinna_reflex1.41719964
34MP0002277_abnormal_respiratory_mucosa1.39132307
35MP0005503_abnormal_tendon_morphology1.35213934
36MP0002882_abnormal_neuron_morphology1.33456805
37MP0001293_anophthalmia1.31647601
38MP0002009_preneoplasia1.30328431
39MP0003123_paternal_imprinting1.25425751
40MP0004142_abnormal_muscle_tone1.25372156
41MP0000778_abnormal_nervous_system1.24555872
42MP0006292_abnormal_olfactory_placode1.20549138
43MP0004019_abnormal_vitamin_homeostasis1.20401023
44MP0009250_abnormal_appendicular_skeleto1.19261771
45MP0005645_abnormal_hypothalamus_physiol1.16402674
46MP0000537_abnormal_urethra_morphology1.16188987
47MP0002102_abnormal_ear_morphology1.13357991
48MP0008877_abnormal_DNA_methylation1.13120381
49MP0004233_abnormal_muscle_weight1.12017284
50MP0009780_abnormal_chondrocyte_physiolo1.10940873
51MP0004134_abnormal_chest_morphology1.10791813
52MP0000579_abnormal_nail_morphology1.09120515
53MP0003385_abnormal_body_wall1.08801006
54MP0001486_abnormal_startle_reflex1.07669545
55MP0001986_abnormal_taste_sensitivity1.06004378
56MP0000681_abnormal_thyroid_gland1.03675421
57MP0003861_abnormal_nervous_system1.01777523
58MP0000470_abnormal_stomach_morphology0.99367811
59MP0008789_abnormal_olfactory_epithelium0.98804149
60MP0000955_abnormal_spinal_cord0.96461029
61MP0009053_abnormal_anal_canal0.95665266
62MP0009384_cardiac_valve_regurgitation0.94089765
63MP0002751_abnormal_autonomic_nervous0.93750145
64MP0002653_abnormal_ependyma_morphology0.89129985
65MP0008875_abnormal_xenobiotic_pharmacok0.87605015
66MP0003755_abnormal_palate_morphology0.86923041
67MP0008995_early_reproductive_senescence0.86475548
68MP0010030_abnormal_orbit_morphology0.84675058
69MP0000647_abnormal_sebaceous_gland0.84056526
70MP0003890_abnormal_embryonic-extraembry0.82657304
71MP0003937_abnormal_limbs/digits/tail_de0.81788687
72MP0001346_abnormal_lacrimal_gland0.80933618
73MP0001984_abnormal_olfaction0.80512189
74MP0004885_abnormal_endolymph0.79851689
75MP0003122_maternal_imprinting0.78962848
76MP0000538_abnormal_urinary_bladder0.78460823
77MP0001881_abnormal_mammary_gland0.78082868
78MP0002295_abnormal_pulmonary_circulatio0.77468506
79MP0003634_abnormal_glial_cell0.77010434
80MP0004924_abnormal_behavior0.76710278
81MP0005386_behavior/neurological_phenoty0.76710278
82MP0004270_analgesia0.76041813
83MP0003936_abnormal_reproductive_system0.74612169
84MP0005646_abnormal_pituitary_gland0.74402113
85MP0001963_abnormal_hearing_physiology0.72182159
86MP0000462_abnormal_digestive_system0.72045261
87MP0002282_abnormal_trachea_morphology0.69749387
88MP0003045_fibrosis0.68851189
89MP0009764_decreased_sensitivity_to0.68114769
90MP0002127_abnormal_cardiovascular_syste0.67673702
91MP0003942_abnormal_urinary_system0.67406221
92MP0000569_abnormal_digit_pigmentation0.66441235
93MP0003935_abnormal_craniofacial_develop0.65956938
94MP0005409_darkened_coat_color0.65043663
95MP0009379_abnormal_foot_pigmentation0.64925805
96MP0002092_abnormal_eye_morphology0.62977384
97MP0004859_abnormal_synaptic_plasticity0.61965451
98MP0001299_abnormal_eye_distance/0.61200769
99MP0005197_abnormal_uvea_morphology0.61144513
100MP0003690_abnormal_glial_cell0.60829165
101MP0003787_abnormal_imprinting0.60458641
102MP0001188_hyperpigmentation0.59513398
103MP0004043_abnormal_pH_regulation0.59339651
104MP0003635_abnormal_synaptic_transmissio0.59182875
105MP0010307_abnormal_tumor_latency0.58334948
106MP0002063_abnormal_learning/memory/cond0.56032560
107MP0002272_abnormal_nervous_system0.54876487
108MP0004215_abnormal_myocardial_fiber0.53780272
109MP0008569_lethality_at_weaning0.51247115
110MP0002064_seizures0.50500274
111MP0002067_abnormal_sensory_capabilities0.48711661
112MP0004742_abnormal_vestibular_system0.48564657
113MP0002572_abnormal_emotion/affect_behav0.43710107
114MP0001286_abnormal_eye_development0.43467090
115MP0005394_taste/olfaction_phenotype0.41633984
116MP0005499_abnormal_olfactory_system0.41633984
117MP0005076_abnormal_cell_differentiation0.41587300
118MP0002557_abnormal_social/conspecific_i0.41114933
119MP0002877_abnormal_melanocyte_morpholog0.39990380
120MP0001879_abnormal_lymphatic_vessel0.38828009
121MP0003705_abnormal_hypodermis_morpholog0.37576842
122MP0009703_decreased_birth_body0.35149354
123MP0001661_extended_life_span0.34934438
124MP0002152_abnormal_brain_morphology0.34172791
125MP0002734_abnormal_mechanical_nocicepti0.32254758
126MP0010234_abnormal_vibrissa_follicle0.32120060
127MP0000026_abnormal_inner_ear0.31123175
128MP0003121_genomic_imprinting0.30872545
129MP0002166_altered_tumor_susceptibility0.30823889
130MP0001968_abnormal_touch/_nociception0.30731022
131MP0009745_abnormal_behavioral_response0.28662963
132MP0003698_abnormal_male_reproductive0.27989061
133MP0000427_abnormal_hair_cycle0.27841057
134MP0002332_abnormal_exercise_endurance0.27617228
135MP0004085_abnormal_heartbeat0.27466864
136MP0005376_homeostasis/metabolism_phenot0.27258811
137MP0002971_abnormal_brown_adipose0.26899569
138MP0008961_abnormal_basal_metabolism0.25706717
139MP0010352_gastrointestinal_tract_polyps0.25348722
140MP0002234_abnormal_pharynx_morphology0.22876303
141MP0004145_abnormal_muscle_electrophysio0.22859777
142MP0002066_abnormal_motor_capabilities/c0.22727781
143MP0005666_abnormal_adipose_tissue0.22723970
144MP0005620_abnormal_muscle_contractility0.22629137
145MP0004811_abnormal_neuron_physiology0.22029131
146MP0000751_myopathy0.21680678
147MP0003300_gastrointestinal_ulcer0.21416747
148MP0000534_abnormal_ureter_morphology0.21020384
149MP0003137_abnormal_impulse_conducting0.20729696
150MP0005171_absent_coat_pigmentation0.20061802
151MP0002184_abnormal_innervation0.19115109
152MP0001727_abnormal_embryo_implantation0.18674986

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.15635342
2Pigmentary retinal degeneration (HP:0001146)8.89278846
3Central scotoma (HP:0000603)8.80003241
4Abnormal rod and cone electroretinograms (HP:0008323)8.63459362
5Abnormality of macular pigmentation (HP:0008002)8.19584546
6Scotoma (HP:0000575)7.96047631
7Chorioretinal atrophy (HP:0000533)7.42647052
8Renal cortical cysts (HP:0000803)7.41101750
9Attenuation of retinal blood vessels (HP:0007843)7.40032489
10Pendular nystagmus (HP:0012043)6.56044457
11Asplenia (HP:0001746)6.30567382
12Enlarged kidneys (HP:0000105)6.03647002
13Aplasia/Hypoplasia of the spleen (HP:0010451)5.85636060
14Abolished electroretinogram (ERG) (HP:0000550)5.85089104
15Decreased central vision (HP:0007663)5.71579387
16Photophobia (HP:0000613)5.54142719
17Posterior subcapsular cataract (HP:0007787)5.49564766
18Type II diabetes mellitus (HP:0005978)5.40192179
19Abnormality of the common coagulation pathway (HP:0010990)5.29436237
20Nephronophthisis (HP:0000090)4.71669595
21Truncus arteriosus (HP:0001660)4.71598359
22Macular degeneration (HP:0000608)4.68841611
23Vitreoretinal degeneration (HP:0000655)4.66484768
24Abnormality of the renal medulla (HP:0100957)4.65472984
25Abnormality of the renal cortex (HP:0011035)4.63541763
26Cone-rod dystrophy (HP:0000548)4.62584751
27Choroideremia (HP:0001139)4.48809084
28Constricted visual fields (HP:0001133)4.38437500
29Severe visual impairment (HP:0001141)4.33546099
30Dynein arm defect of respiratory motile cilia (HP:0012255)4.21944896
31Absent/shortened dynein arms (HP:0200106)4.21944896
32Subcapsular cataract (HP:0000523)4.10828299
33Retinitis pigmentosa (HP:0000510)4.06194031
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97403483
35Increased corneal curvature (HP:0100692)3.95633559
36Keratoconus (HP:0000563)3.95633559
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.83283700
38Abnormality of alanine metabolism (HP:0010916)3.83283700
39Hyperalaninemia (HP:0003348)3.83283700
40Femoral bowing (HP:0002980)3.66517932
41Myokymia (HP:0002411)3.63857626
42Abnormal respiratory epithelium morphology (HP:0012253)3.60474887
43Abnormal respiratory motile cilium morphology (HP:0005938)3.60474887
44Abnormal respiratory motile cilium physiology (HP:0012261)3.57657521
45Hypoplastic pelvis (HP:0008839)3.56645446
46Rhinitis (HP:0012384)3.52839365
47Decreased electroretinogram (ERG) amplitude (HP:0000654)3.46498952
48Abnormal ciliary motility (HP:0012262)3.41297160
49Retinal atrophy (HP:0001105)3.18239338
50Abnormality of the phalanges of the 2nd finger (HP:0009541)3.13964339
51Abnormality of DNA repair (HP:0003254)3.09906045
52Oligodactyly (hands) (HP:0001180)3.05040671
53Progressive visual loss (HP:0000529)2.90053357
54Increased serum ferritin (HP:0003281)2.80799037
55Congenital sensorineural hearing impairment (HP:0008527)2.78087041
56Long nose (HP:0003189)2.66746379
57Stillbirth (HP:0003826)2.57398493
58Anterior segment dysgenesis (HP:0007700)2.51253037
59Dry hair (HP:0011359)2.47665291
60Abnormality of the 2nd finger (HP:0004100)2.45548145
61Short 4th metacarpal (HP:0010044)2.39920839
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39920839
63Preauricular pit (HP:0004467)2.39540574
64Periauricular skin pits (HP:0100277)2.39540574
65Wide nasal bridge (HP:0000431)2.39010640
66Abnormality of the parietal bone (HP:0002696)2.38319458
67Pulmonary hypoplasia (HP:0002089)2.34428450
68Hypoplastic left heart (HP:0004383)2.32931323
69Nonprogressive disorder (HP:0003680)2.30384033
70Stage 5 chronic kidney disease (HP:0003774)2.29355529
71Parakeratosis (HP:0001036)2.29148139
72Optic disc pallor (HP:0000543)2.24389786
73Macroorchidism (HP:0000053)2.18419277
74Abnormality of the 4th metacarpal (HP:0010012)2.16282013
75Abnormality of iron homeostasis (HP:0011031)2.15041071
76Polar cataract (HP:0010696)2.14673102
77Type 2 muscle fiber atrophy (HP:0003554)2.13347239
78Coronal craniosynostosis (HP:0004440)2.11676304
79Osteomalacia (HP:0002749)2.08921330
80Abnormality of the pons (HP:0007361)2.07125622
81Gait imbalance (HP:0002141)2.05862263
82Congenital, generalized hypertrichosis (HP:0004540)2.04368945
83Lip pit (HP:0100267)2.04122459
84Aplasia of the musculature (HP:0100854)2.03616898
85Split foot (HP:0001839)2.03151805
86Congenital primary aphakia (HP:0007707)2.02857450
87Thickened helices (HP:0000391)2.01350377
88Congenital stationary night blindness (HP:0007642)12.9703721
89Bony spicule pigmentary retinopathy (HP:0007737)11.4761987
90Dyschromatopsia (HP:0007641)10.0168847
91Volvulus (HP:0002580)1.98999009
92Poor suck (HP:0002033)1.97311976
93Oligodactyly (HP:0012165)1.97140738
94Hyperkalemia (HP:0002153)1.92195641
95Anophthalmia (HP:0000528)1.92151936
96Neuroendocrine neoplasm (HP:0100634)1.91909092
97Abnormality of macrophages (HP:0004311)1.91326595
98Skin pits (HP:0100276)1.85216795
99Abnormality of transition element cation homeostasis (HP:0011030)1.84057399
100Down-sloping shoulders (HP:0200021)1.83774403
101Torticollis (HP:0000473)1.83555253
102Hypoplastic heart (HP:0001961)1.82393453
103Horizontal nystagmus (HP:0000666)1.81317089
104Cellular immunodeficiency (HP:0005374)1.78911651
105Hypoplasia of the pons (HP:0012110)1.76249340
106Nephrogenic diabetes insipidus (HP:0009806)1.75168132
107Chronic bronchitis (HP:0004469)1.75146440
108Abnormality of the intrinsic pathway (HP:0010989)1.75132172
109Tubulointerstitial nephritis (HP:0001970)1.73633808
110Thyroid-stimulating hormone excess (HP:0002925)1.73548937
111Muscle fiber atrophy (HP:0100295)1.72758856
112Bronchiectasis (HP:0002110)1.71242404
113Tubulointerstitial fibrosis (HP:0005576)1.70580694
114Medial flaring of the eyebrow (HP:0010747)1.70398717
115Truncal ataxia (HP:0002078)1.70261903
116Type II lissencephaly (HP:0007260)1.69411004
117Tubulointerstitial abnormality (HP:0001969)1.69019107
118Dysdiadochokinesis (HP:0002075)1.68926151
119Rectovaginal fistula (HP:0000143)1.68162618
120Rectal fistula (HP:0100590)1.68162618
121Abnormality of the neuromuscular junction (HP:0003398)1.67252301
122Fatigable weakness (HP:0003473)1.67252301
123Focal dystonia (HP:0004373)1.66954826
124Partial duplication of the phalanx of hand (HP:0009999)1.66861275
125Mesangial abnormality (HP:0001966)1.65367647
126Hypertriglyceridemia (HP:0002155)1.65299039
127Turricephaly (HP:0000262)1.65214983
128Abnormality of the frontal sinuses (HP:0002687)1.61843822
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61157034
130Decreased testicular size (HP:0008734)1.56950615
131Poor coordination (HP:0002370)1.51464089
132Truncal obesity (HP:0001956)1.43733865
133Optic atrophy (HP:0000648)1.40570306
134Heterotopia (HP:0002282)1.38341029
135Severe Myopia (HP:0011003)1.36701186
136Retinal detachment (HP:0000541)1.33958422
137Vaginal atresia (HP:0000148)1.30247633
138Progressive cerebellar ataxia (HP:0002073)1.30222090
139Genital tract atresia (HP:0001827)1.30191904
140Broad-based gait (HP:0002136)1.25055519
141Epileptic encephalopathy (HP:0200134)1.23078732
142Febrile seizures (HP:0002373)1.20902467
143Obsessive-compulsive behavior (HP:0000722)1.20101843
144Astigmatism (HP:0000483)1.20007152
145Pancreatic fibrosis (HP:0100732)1.16335989
146Inappropriate behavior (HP:0000719)1.13606293
147Aqueductal stenosis (HP:0002410)1.11349508
148Increased nuchal translucency (HP:0010880)1.07648546
149Hyperventilation (HP:0002883)1.07560713
150Aplasia/Hypoplasia of the lens (HP:0008063)1.06240373
151True hermaphroditism (HP:0010459)1.05363468
152Abnormality of chromosome segregation (HP:0002916)1.04177290
153Hypogonadotrophic hypogonadism (HP:0000044)1.04047364
154Hypochromic microcytic anemia (HP:0004840)1.02384994
155Abnormality of the fovea (HP:0000493)1.02289231
156X-linked recessive inheritance (HP:0001419)1.01110776
157Broad foot (HP:0001769)1.01109862
158Abnormality of ocular smooth pursuit (HP:0000617)1.00733623
159Genetic anticipation (HP:0003743)1.00514725
160Interstitial pulmonary disease (HP:0006530)0.99337305
161Protruding tongue (HP:0010808)0.98497681
162Action tremor (HP:0002345)0.98067237
163Visual hallucinations (HP:0002367)0.97295364
164Astrocytoma (HP:0009592)0.96412339
165Abnormality of the astrocytes (HP:0100707)0.96412339
166Molar tooth sign on MRI (HP:0002419)0.95384654
167Abnormality of midbrain morphology (HP:0002418)0.95384654
168Excessive salivation (HP:0003781)0.93482963
169Drooling (HP:0002307)0.93482963
170Specific learning disability (HP:0001328)0.92736128
171Impaired smooth pursuit (HP:0007772)0.92263099
172Depression (HP:0000716)0.90411581
173Cystic liver disease (HP:0006706)0.90010283
174Ankyloglossia (HP:0010296)0.89392855
175Short foot (HP:0001773)0.89236477
176Gaze-evoked nystagmus (HP:0000640)0.88292276
177Aplasia/Hypoplasia of the tongue (HP:0010295)0.88099940
178Pancreatic cysts (HP:0001737)0.87778568
179Abnormal EKG (HP:0003115)0.87437712
180Aplasia/Hypoplasia of the fovea (HP:0008060)0.84098076
181Hypoplasia of the fovea (HP:0007750)0.84098076
182Pheochromocytoma (HP:0002666)0.83676468
183Chronic hepatic failure (HP:0100626)0.83450594
184Increased number of teeth (HP:0011069)0.82690069
185Hyperthyroidism (HP:0000836)0.82341950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.27371672
2STK394.21251063
3PBK4.18658531
4MAPK153.20694814
5CDK122.99342492
6PAK32.97576881
7MAP3K102.92929670
8ADRBK22.68028441
9YES12.37786502
10CASK2.32106162
11MELK2.30392817
12MAP2K22.26852436
13MARK22.26194092
14BRD42.03724951
15BRAF2.01201557
16LIMK11.84139186
17HIPK21.81514265
18DYRK1B1.77544299
19PINK11.74160233
20GRK51.73752844
21ACVR1B1.72768417
22CAMK11.68084779
23TRPM71.64309229
24SCYL21.61501067
25CDK61.58118704
26NEK11.56618511
27CAMK1G1.55958167
28ADRBK11.49736304
29MAP3K21.49580163
30CAMK1D1.48747138
31ZAK1.45289265
32IRAK21.42226526
33FGFR21.32187546
34DYRK21.31343416
35UHMK11.31103253
36NEK21.30189055
37CDC71.28646727
38MAP3K41.24707552
39EPHB21.19199296
40FRK1.17936886
41PDK21.17288267
42PAK21.15977596
43RPS6KA21.13871071
44SRPK11.11810314
45CSNK1D1.11804405
46EPHA41.11271822
47PAK61.10456294
48MAP3K61.09625598
49NTRK31.09289082
50SIK21.06054473
51FGFR31.03958547
52MAPK71.02702814
53TLK10.99054148
54OXSR10.98068536
55MARK10.95777836
56MUSK0.95666377
57TESK20.92609757
58MAP3K70.91887192
59MAPK120.91445132
60WNK10.90726526
61SGK4940.88986010
62SGK2230.88986010
63ERBB30.88916876
64WNK30.88077965
65LATS10.86319378
66CDC42BPA0.85995202
67BRSK10.83345670
68TTK0.82474907
69PLK30.82310124
70SGK20.82165270
71SGK30.82140144
72CSNK1G20.80125257
73CDK90.79918254
74ABL20.79777164
75MAPK40.79320626
76CDK150.78561015
77CHEK20.78409339
78TESK10.75806676
79CDK180.73739818
80STK38L0.73604953
81RPS6KA60.73365242
82KSR10.73087567
83DYRK30.72679842
84MAP2K40.71890211
85PRKCG0.71018993
86STK380.70119709
87DYRK1A0.69900105
88SGK10.69790146
89PLK20.69714165
90ATM0.69449396
91RPS6KL10.69273581
92RPS6KC10.69273581
93ATR0.68666353
94RIPK10.67417873
95CDK10.67313581
96PRKCH0.67211591
97STK240.66635134
98KSR20.66546168
99CDK11A0.66016806
100CDK40.65615223
101BCR0.65438856
102NTRK20.65295254
103RET0.65039038
104PASK0.65037578
105PNCK0.64599922
106CAMKK10.64027431
107PRKCB0.63721315
108MINK10.63184940
109MAP3K90.61805583
110PRKDC0.61779852
111CAMK2D0.61285324
112CDK190.60368267
113MAPK100.59547501
114TYRO30.57641994
115ERBB20.57431943
116MAPK140.55908947
117NME10.55820326
118GSK3B0.55747132
119RPS6KA30.55741512
120TAOK30.55672175
121CDK50.54886834
122AKT20.54842642
123CDK140.54125173
124CHEK10.53677852
125CDK30.53358240
126TGFBR10.53040669
127STK110.52169048
128MAP2K10.51458459
129AURKB0.49942849
130MAP2K70.48042783
131PRKAA10.46918100
132PRKCZ0.46394171
133BRSK20.45951006
134CDK20.45048352
135AKT30.42460916
136PHKG10.41753185
137PHKG20.41753185
138INSRR0.41628639
139RPS6KA40.41505438
140KIT0.41010063
141FGFR10.40027715
142PDGFRB0.39702025
143PRKCD0.39587269
144RPS6KA10.39343109
145BMPR1B0.38636975
146PRKACA0.38196517
147CSNK1E0.37802072
148CCNB10.37712480
149VRK10.37554926
150IKBKE0.37093260
151MAPK90.34655854
152PRKAA20.34581522
153MATK0.34138334
154PRKD10.33434171
155STK30.33377495
156PDK10.33199663
157WNK40.33037353
158MAP3K120.31706862
159CAMKK20.30687020
160PKN10.28112952
161MAP3K50.26407614
162MAPK130.25899537

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.38213698
2Oxidative phosphorylation_Homo sapiens_hsa001903.61500627
3Basal cell carcinoma_Homo sapiens_hsa052173.20822587
4Parkinsons disease_Homo sapiens_hsa050122.82891485
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.68809511
6Huntingtons disease_Homo sapiens_hsa050162.58687465
7Ribosome_Homo sapiens_hsa030102.48972817
8* Phototransduction_Homo sapiens_hsa0474415.0381686
9Alzheimers disease_Homo sapiens_hsa050101.98611066
10Sulfur relay system_Homo sapiens_hsa041221.91342495
11Notch signaling pathway_Homo sapiens_hsa043301.85848908
12Hedgehog signaling pathway_Homo sapiens_hsa043401.63404129
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54730949
14Axon guidance_Homo sapiens_hsa043601.50318277
15Cardiac muscle contraction_Homo sapiens_hsa042601.49731712
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49656559
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42851984
18Protein export_Homo sapiens_hsa030601.40340025
19Steroid biosynthesis_Homo sapiens_hsa001001.35320576
20Autoimmune thyroid disease_Homo sapiens_hsa053201.29429954
21Synaptic vesicle cycle_Homo sapiens_hsa047211.29104708
22Collecting duct acid secretion_Homo sapiens_hsa049661.28972543
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28741041
24Selenocompound metabolism_Homo sapiens_hsa004501.27262368
25GnRH signaling pathway_Homo sapiens_hsa049121.26905506
26Olfactory transduction_Homo sapiens_hsa047401.26684937
27Melanogenesis_Homo sapiens_hsa049161.25123739
28Ovarian steroidogenesis_Homo sapiens_hsa049131.22505320
29Circadian rhythm_Homo sapiens_hsa047101.08028532
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07985611
31GABAergic synapse_Homo sapiens_hsa047271.07520376
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.03847400
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03175428
34Regulation of autophagy_Homo sapiens_hsa041401.00988032
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00935926
36Circadian entrainment_Homo sapiens_hsa047130.99404994
37Tryptophan metabolism_Homo sapiens_hsa003800.97868951
38Histidine metabolism_Homo sapiens_hsa003400.97817457
39Vibrio cholerae infection_Homo sapiens_hsa051100.95038963
40Glutamatergic synapse_Homo sapiens_hsa047240.94852190
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.93951244
42Thyroid cancer_Homo sapiens_hsa052160.92175041
43Gap junction_Homo sapiens_hsa045400.91635339
44Cholinergic synapse_Homo sapiens_hsa047250.90145473
45Serotonergic synapse_Homo sapiens_hsa047260.89901680
46Type II diabetes mellitus_Homo sapiens_hsa049300.87214462
47Dopaminergic synapse_Homo sapiens_hsa047280.84942945
48Pathways in cancer_Homo sapiens_hsa052000.82637917
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80209120
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79745655
51Morphine addiction_Homo sapiens_hsa050320.79177287
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.76643599
53Chemical carcinogenesis_Homo sapiens_hsa052040.75795828
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75024658
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74466035
56Asthma_Homo sapiens_hsa053100.71621928
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68737239
58ECM-receptor interaction_Homo sapiens_hsa045120.68694761
59Linoleic acid metabolism_Homo sapiens_hsa005910.68042245
60Small cell lung cancer_Homo sapiens_hsa052220.67085502
61Calcium signaling pathway_Homo sapiens_hsa040200.65491102
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65466101
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64186730
64Folate biosynthesis_Homo sapiens_hsa007900.64087532
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63370522
66Alcoholism_Homo sapiens_hsa050340.63240611
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62030062
68beta-Alanine metabolism_Homo sapiens_hsa004100.61047279
69Thyroid hormone synthesis_Homo sapiens_hsa049180.60506892
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.60250506
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59878945
72Oxytocin signaling pathway_Homo sapiens_hsa049210.59212888
73Retinol metabolism_Homo sapiens_hsa008300.59168679
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57488692
75Caffeine metabolism_Homo sapiens_hsa002320.57176658
76Nitrogen metabolism_Homo sapiens_hsa009100.55021978
77Insulin secretion_Homo sapiens_hsa049110.54336326
78Nicotine addiction_Homo sapiens_hsa050330.53639680
79ABC transporters_Homo sapiens_hsa020100.52070067
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51684693
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51249685
82mTOR signaling pathway_Homo sapiens_hsa041500.50615599
83Ether lipid metabolism_Homo sapiens_hsa005650.49843744
84Lysine degradation_Homo sapiens_hsa003100.48026420
85Melanoma_Homo sapiens_hsa052180.47708344
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45412827
87Dorso-ventral axis formation_Homo sapiens_hsa043200.45037476
88Long-term potentiation_Homo sapiens_hsa047200.43529029
89AMPK signaling pathway_Homo sapiens_hsa041520.43493358
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42053309
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41480115
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.40449071
93FoxO signaling pathway_Homo sapiens_hsa040680.38507888
94Inositol phosphate metabolism_Homo sapiens_hsa005620.38382326
95Renin secretion_Homo sapiens_hsa049240.37239321
96VEGF signaling pathway_Homo sapiens_hsa043700.37161098
97Prolactin signaling pathway_Homo sapiens_hsa049170.36268968
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36128116
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35845078
100Choline metabolism in cancer_Homo sapiens_hsa052310.35540134
101Fatty acid biosynthesis_Homo sapiens_hsa000610.35484237
102African trypanosomiasis_Homo sapiens_hsa051430.35477304
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34481469
104Long-term depression_Homo sapiens_hsa047300.34477588
105Dilated cardiomyopathy_Homo sapiens_hsa054140.34295983
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34212771
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33763312
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.33122320
109Rheumatoid arthritis_Homo sapiens_hsa053230.33103125
110Salivary secretion_Homo sapiens_hsa049700.32896826
111Peroxisome_Homo sapiens_hsa041460.31832049
112Oocyte meiosis_Homo sapiens_hsa041140.31551030
113Gastric acid secretion_Homo sapiens_hsa049710.30770617
114cAMP signaling pathway_Homo sapiens_hsa040240.30618310
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30236566
116Basal transcription factors_Homo sapiens_hsa030220.29998770
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29736009
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28784417
119Pyruvate metabolism_Homo sapiens_hsa006200.27724432
120Insulin signaling pathway_Homo sapiens_hsa049100.27427329
121Protein digestion and absorption_Homo sapiens_hsa049740.26976746
122Taste transduction_Homo sapiens_hsa047420.26689191
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26174836
124Amphetamine addiction_Homo sapiens_hsa050310.26118309
125Glucagon signaling pathway_Homo sapiens_hsa049220.25893953
126Mineral absorption_Homo sapiens_hsa049780.25778654
127MAPK signaling pathway_Homo sapiens_hsa040100.25527960
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24996249
129Glycerolipid metabolism_Homo sapiens_hsa005610.24722272
130Chemokine signaling pathway_Homo sapiens_hsa040620.23438858
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.23219302
132Cocaine addiction_Homo sapiens_hsa050300.22640747
133Ras signaling pathway_Homo sapiens_hsa040140.20818844
134Glioma_Homo sapiens_hsa052140.20776331
135HIF-1 signaling pathway_Homo sapiens_hsa040660.20747272
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20685516
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20277756
138Colorectal cancer_Homo sapiens_hsa052100.20016543
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.18513864
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18388949
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17732464
142Fatty acid metabolism_Homo sapiens_hsa012120.17529784
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.17388954
144ErbB signaling pathway_Homo sapiens_hsa040120.16732127
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16518139
146Arginine biosynthesis_Homo sapiens_hsa002200.15624132
147Bile secretion_Homo sapiens_hsa049760.13740639
148Adherens junction_Homo sapiens_hsa045200.13703636
149Wnt signaling pathway_Homo sapiens_hsa043100.13087891
150Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11987274
151Tight junction_Homo sapiens_hsa045300.11778271
152Non-small cell lung cancer_Homo sapiens_hsa052230.10638517
153* Purine metabolism_Homo sapiens_hsa002300.10378228
154Insulin resistance_Homo sapiens_hsa049310.10132812
155Hippo signaling pathway_Homo sapiens_hsa043900.10124525
156Cell cycle_Homo sapiens_hsa041100.10088759
157Pancreatic secretion_Homo sapiens_hsa049720.09367898
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09337630

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