GUCY2GP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)6.61951716
2multicellular organism reproduction (GO:0032504)6.61920006
3sperm motility (GO:0030317)6.58565559
4pyrimidine-containing compound transmembrane transport (GO:0072531)6.21616139
5cellular ketone body metabolic process (GO:0046950)5.94773857
6fucose catabolic process (GO:0019317)5.67876382
7L-fucose metabolic process (GO:0042354)5.67876382
8L-fucose catabolic process (GO:0042355)5.67876382
9vitamin transmembrane transport (GO:0035461)5.57692919
10positive regulation of triglyceride biosynthetic process (GO:0010867)5.34605282
11ketone body metabolic process (GO:1902224)5.23581732
12inner ear receptor cell differentiation (GO:0060113)4.82237158
13negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.80520521
14centriole replication (GO:0007099)4.67574363
15reproduction (GO:0000003)4.57319373
16regulation of memory T cell differentiation (GO:0043380)4.44870491
17regulation of triglyceride biosynthetic process (GO:0010866)4.42764637
18glomerular visceral epithelial cell development (GO:0072015)4.42672739
19nephron tubule morphogenesis (GO:0072078)4.42295297
20nephron epithelium morphogenesis (GO:0072088)4.42295297
21cellular response to exogenous dsRNA (GO:0071360)4.38273498
22macroautophagy (GO:0016236)4.28864196
23cilium or flagellum-dependent cell motility (GO:0001539)4.21099858
24establishment of protein localization to Golgi (GO:0072600)4.15367545
25regulation of mesenchymal cell apoptotic process (GO:2001053)4.12729702
26glomerular epithelial cell development (GO:0072310)4.12668436
27protein targeting to Golgi (GO:0000042)4.11515862
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.06439164
29negative regulation of translation, ncRNA-mediated (GO:0040033)4.06439164
30regulation of translation, ncRNA-mediated (GO:0045974)4.06439164
31fusion of sperm to egg plasma membrane (GO:0007342)3.99045177
32RNA destabilization (GO:0050779)3.90510200
33positive regulation of defense response to virus by host (GO:0002230)3.86381447
34behavioral response to nicotine (GO:0035095)3.84483500
35retrograde transport, vesicle recycling within Golgi (GO:0000301)3.82853051
36negative regulation of inclusion body assembly (GO:0090084)3.81658065
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.73132048
38detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.68566833
39protein polyglutamylation (GO:0018095)3.67121916
40sperm-egg recognition (GO:0035036)3.58960173
41mechanoreceptor differentiation (GO:0042490)3.52507917
42regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.51486635
43protein localization to Golgi apparatus (GO:0034067)3.49147771
44positive regulation of triglyceride metabolic process (GO:0090208)3.47078521
45centriole assembly (GO:0098534)3.42785600
46protein localization to cytoskeleton (GO:0044380)3.38836116
47regulation of centriole replication (GO:0046599)3.34879854
48protein localization to microtubule cytoskeleton (GO:0072698)3.34757611
49membrane depolarization during action potential (GO:0086010)3.33528752
50tolerance induction (GO:0002507)3.32489931
51protein K48-linked deubiquitination (GO:0071108)3.31976959
52single fertilization (GO:0007338)3.31842362
53microtubule polymerization or depolymerization (GO:0031109)3.28741668
54negative regulation of reactive oxygen species metabolic process (GO:2000378)3.27143729
55plasma membrane fusion (GO:0045026)3.27122207
56microtubule depolymerization (GO:0007019)3.25677649
57regulation of triglyceride catabolic process (GO:0010896)3.24646067
58positive regulation of CREB transcription factor activity (GO:0032793)3.21580170
59piRNA metabolic process (GO:0034587)3.19470445
60positive regulation of endothelial cell differentiation (GO:0045603)3.15318817
61primary amino compound metabolic process (GO:1901160)3.14304182
62cornea development in camera-type eye (GO:0061303)3.13017660
63fertilization (GO:0009566)3.12530491
64auditory receptor cell stereocilium organization (GO:0060088)3.12491581
65indolalkylamine catabolic process (GO:0046218)3.12356797
66tryptophan catabolic process (GO:0006569)3.12356797
67indole-containing compound catabolic process (GO:0042436)3.12356797
68cell-cell recognition (GO:0009988)3.08201548
69natural killer cell activation involved in immune response (GO:0002323)3.08034660
70regulation of triglyceride metabolic process (GO:0090207)3.06686563
71calcium ion import (GO:0070509)3.01973942
72cysteine metabolic process (GO:0006534)3.01863426
73axoneme assembly (GO:0035082)3.00869498
74regulation of sequestering of triglyceride (GO:0010889)2.99519105
75sulfur compound transport (GO:0072348)2.95917802
76response to misfolded protein (GO:0051788)2.94738469
77fucosylation (GO:0036065)2.94290007
78axonemal dynein complex assembly (GO:0070286)2.90184815
79positive regulation of fatty acid oxidation (GO:0046321)2.89609830
80male meiosis (GO:0007140)2.88739150
81seminiferous tubule development (GO:0072520)2.88166568
82spermatid development (GO:0007286)2.87722039
83acrosome reaction (GO:0007340)2.86501438
84fucose metabolic process (GO:0006004)2.83270255
85rRNA catabolic process (GO:0016075)2.83221907
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.83100004
87rhodopsin mediated signaling pathway (GO:0016056)2.82752436
88positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81802597
89male gamete generation (GO:0048232)2.81627053
90spermatogenesis (GO:0007283)2.81167956
91detection of light stimulus involved in sensory perception (GO:0050962)2.75817579
92detection of light stimulus involved in visual perception (GO:0050908)2.75817579
93lysosome organization (GO:0007040)2.74985137
94lytic vacuole organization (GO:0080171)2.74985137
95opioid receptor signaling pathway (GO:0038003)2.74449023
96organic cation transport (GO:0015695)2.74160786
97male meiosis I (GO:0007141)2.71737457
98motile cilium assembly (GO:0044458)2.71545799
99negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.70587342
100regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.70389138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68485199
2ZNF274_21170338_ChIP-Seq_K562_Hela4.43383030
3GATA1_22025678_ChIP-Seq_K562_Human3.23826942
4VDR_22108803_ChIP-Seq_LS180_Human3.20155420
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09056105
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06477199
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.27907127
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27907127
9GBX2_23144817_ChIP-Seq_PC3_Human2.22310762
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17392080
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.09880806
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.02719785
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00264032
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87732467
15DROSHA_22980978_ChIP-Seq_HELA_Human1.84081539
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73859195
17ER_23166858_ChIP-Seq_MCF-7_Human1.69628758
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.60342981
19AR_21572438_ChIP-Seq_LNCaP_Human1.53050304
20FUS_26573619_Chip-Seq_HEK293_Human1.51172832
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50474201
22TAF2_19829295_ChIP-Seq_ESCs_Human1.50042992
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48768721
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48544058
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.48501913
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48484457
27STAT3_23295773_ChIP-Seq_U87_Human1.45822121
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44337450
29* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43652913
30* FOXA1_25329375_ChIP-Seq_VCAP_Human1.43652913
31MYC_19829295_ChIP-Seq_ESCs_Human1.43484415
32TAF15_26573619_Chip-Seq_HEK293_Human1.41412613
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39123487
34CBP_20019798_ChIP-Seq_JUKART_Human1.38809800
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38809800
36NANOG_20526341_ChIP-Seq_ESCs_Human1.38488148
37TP53_22573176_ChIP-Seq_HFKS_Human1.37788762
38P300_19829295_ChIP-Seq_ESCs_Human1.37398532
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.37234637
40AHR_22903824_ChIP-Seq_MCF-7_Human1.35459702
41SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34980466
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33190682
43SOX2_19829295_ChIP-Seq_ESCs_Human1.32143373
44NANOG_19829295_ChIP-Seq_ESCs_Human1.32143373
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30743897
46AR_25329375_ChIP-Seq_VCAP_Human1.30450170
47* ERA_21632823_ChIP-Seq_H3396_Human1.30209931
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26868291
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25725258
50TCF4_23295773_ChIP-Seq_U87_Human1.22381494
51* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21838372
52* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21336197
53TP53_16413492_ChIP-PET_HCT116_Human1.21322357
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.21164573
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19898217
56* HOXB7_26014856_ChIP-Seq_BT474_Human1.19133261
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18794699
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.18211046
59BCAT_22108803_ChIP-Seq_LS180_Human1.17746727
60IRF1_19129219_ChIP-ChIP_H3396_Human1.17122338
61RAC3_21632823_ChIP-Seq_H3396_Human1.15095540
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15034021
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12570893
64AR_20517297_ChIP-Seq_VCAP_Human1.12284143
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12066055
66OCT4_20526341_ChIP-Seq_ESCs_Human1.12041024
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07902497
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07470488
69REST_21632747_ChIP-Seq_MESCs_Mouse1.06915870
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06528714
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.06396982
72RUNX2_22187159_ChIP-Seq_PCA_Human1.06284156
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05380412
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04191293
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03607998
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03404289
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03261040
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03140832
79* GATA4_25053715_ChIP-Seq_YYC3_Human1.02790919
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.01946043
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01927608
82SMAD4_21799915_ChIP-Seq_A2780_Human1.01847857
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.01205349
84NFYB_21822215_ChIP-Seq_K562_Human1.00462155
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00247715
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00220709
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.99827754
88* TCF4_22108803_ChIP-Seq_LS180_Human0.99079024
89* CEBPB_22108803_ChIP-Seq_LS180_Human0.98838381
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.97965860
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97671140
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.97182901
93CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96835121
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96442881
95TBL1_22424771_ChIP-Seq_293T_Human0.95572428
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95234501
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95148097
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94564958
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.94246545
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93200294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.27427726
2MP0003878_abnormal_ear_physiology5.27427726
3MP0003195_calcinosis4.77582964
4MP0001485_abnormal_pinna_reflex4.43630720
5MP0005410_abnormal_fertilization3.72936244
6MP0004742_abnormal_vestibular_system3.67280855
7MP0003136_yellow_coat_color3.54154640
8MP0002102_abnormal_ear_morphology2.97634786
9MP0004885_abnormal_endolymph2.83236868
10MP0003879_abnormal_hair_cell2.61247824
11MP0005670_abnormal_white_adipose2.54117114
12MP0008877_abnormal_DNA_methylation2.47555292
13MP0009780_abnormal_chondrocyte_physiolo2.25825310
14MP0002876_abnormal_thyroid_physiology2.15334395
15MP0008875_abnormal_xenobiotic_pharmacok2.11993579
16MP0004147_increased_porphyrin_level2.08756655
17MP0009840_abnormal_foam_cell2.07155484
18MP0002653_abnormal_ependyma_morphology1.97067414
19MP0001986_abnormal_taste_sensitivity1.97045614
20MP0001929_abnormal_gametogenesis1.74318141
21MP0008872_abnormal_physiological_respon1.73018843
22MP0003698_abnormal_male_reproductive1.72968745
23MP0010329_abnormal_lipoprotein_level1.62574937
24MP0003718_maternal_effect1.52158116
25MP0009745_abnormal_behavioral_response1.50975905
26MP0001968_abnormal_touch/_nociception1.50043924
27MP0004142_abnormal_muscle_tone1.47336798
28MP0001486_abnormal_startle_reflex1.46686586
29MP0000230_abnormal_systemic_arterial1.45616008
30MP0005551_abnormal_eye_electrophysiolog1.44975068
31MP0005365_abnormal_bile_salt1.43680450
32MP0005360_urolithiasis1.38501235
33MP0001963_abnormal_hearing_physiology1.38367961
34MP0009379_abnormal_foot_pigmentation1.37427148
35MP0000372_irregular_coat_pigmentation1.34698373
36MP0000026_abnormal_inner_ear1.33331887
37MP0004043_abnormal_pH_regulation1.28786553
38MP0009764_decreased_sensitivity_to1.23583910
39MP0005253_abnormal_eye_physiology1.23078234
40MP0002735_abnormal_chemical_nociception1.16920909
41MP0002067_abnormal_sensory_capabilities1.13505830
42MP0005085_abnormal_gallbladder_physiolo1.12434982
43MP0003646_muscle_fatigue1.12333572
44MP0001764_abnormal_homeostasis1.11868708
45MP0005595_abnormal_vascular_smooth1.07985164
46MP0002938_white_spotting1.02785751
47MP0002282_abnormal_trachea_morphology1.02104254
48MP0000538_abnormal_urinary_bladder0.99053601
49MP0005310_abnormal_salivary_gland0.95800700
50MP0002736_abnormal_nociception_after0.94034517
51MP0002272_abnormal_nervous_system0.93174151
52MP0001765_abnormal_ion_homeostasis0.91906427
53MP0008961_abnormal_basal_metabolism0.91365905
54MP0002210_abnormal_sex_determination0.90259419
55MP0005671_abnormal_response_to0.89758872
56MP0005379_endocrine/exocrine_gland_phen0.89144656
57MP0003329_amyloid_beta_deposits0.88312426
58MP0002132_abnormal_respiratory_system0.87865315
59MP0002138_abnormal_hepatobiliary_system0.86876434
60MP0002557_abnormal_social/conspecific_i0.86841396
61MP0002064_seizures0.86256183
62MP0001664_abnormal_digestion0.85659469
63MP0002161_abnormal_fertility/fecundity0.82945797
64MP0002572_abnormal_emotion/affect_behav0.81947652
65MP0001501_abnormal_sleep_pattern0.81686089
66MP0009384_cardiac_valve_regurgitation0.80406689
67MP0002638_abnormal_pupillary_reflex0.78778142
68MP0002118_abnormal_lipid_homeostasis0.77529008
69MP0005386_behavior/neurological_phenoty0.77104462
70MP0004924_abnormal_behavior0.77104462
71MP0005332_abnormal_amino_acid0.76298806
72MP0001324_abnormal_eye_pigmentation0.75989077
73MP0001919_abnormal_reproductive_system0.75595339
74MP0003950_abnormal_plasma_membrane0.75061876
75MP0003638_abnormal_response/metabolism_0.73878436
76MP0004133_heterotaxia0.73861986
77MP0000427_abnormal_hair_cycle0.73594623
78MP0004130_abnormal_muscle_cell0.73434929
79MP0003632_abnormal_nervous_system0.72872577
80MP0001970_abnormal_pain_threshold0.72844257
81MP0001529_abnormal_vocalization0.72003512
82MP0005167_abnormal_blood-brain_barrier0.67728029
83MP0005165_increased_susceptibility_to0.66307532
84MP0009278_abnormal_bone_marrow0.64752238
85MP0005083_abnormal_biliary_tract0.64419704
86MP0002063_abnormal_learning/memory/cond0.63590885
87MP0005084_abnormal_gallbladder_morpholo0.63482348
88MP0005195_abnormal_posterior_eye0.63340617
89MP0002733_abnormal_thermal_nociception0.63267225
90MP0002693_abnormal_pancreas_physiology0.62152706
91MP0005395_other_phenotype0.61988857
92MP0001851_eye_inflammation0.60656097
93MP0002136_abnormal_kidney_physiology0.60478495
94MP0002229_neurodegeneration0.60435416
95MP0004145_abnormal_muscle_electrophysio0.59666986
96MP0003959_abnormal_lean_body0.59413528
97MP0002277_abnormal_respiratory_mucosa0.59148738
98MP0005391_vision/eye_phenotype0.58437460
99MP0002928_abnormal_bile_duct0.58114492
100MP0000343_altered_response_to0.57767797

Predicted human phenotypes

RankGene SetZ-score
1Potter facies (HP:0002009)5.10297640
2Facial shape deformation (HP:0011334)5.10297640
3Chronic hepatic failure (HP:0100626)5.02337186
4Inability to walk (HP:0002540)4.86081590
5Molar tooth sign on MRI (HP:0002419)4.10482057
6Abnormality of midbrain morphology (HP:0002418)4.10482057
7Tubular atrophy (HP:0000092)4.04371928
8Concave nail (HP:0001598)4.00783749
9Renovascular hypertension (HP:0100817)3.75965352
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.67173285
11Confusion (HP:0001289)3.65126060
12Decreased central vision (HP:0007663)3.55583827
13Mutism (HP:0002300)3.52114232
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.51848676
15Absent/shortened dynein arms (HP:0200106)3.51848676
16Tubulointerstitial nephritis (HP:0001970)3.50353834
17True hermaphroditism (HP:0010459)3.45678811
18Progressive sensorineural hearing impairment (HP:0000408)3.44504493
19Birth length less than 3rd percentile (HP:0003561)3.37441756
20Hypoplastic iliac wings (HP:0002866)3.34235652
21Pancreatic cysts (HP:0001737)3.31630186
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.23592156
23Type II lissencephaly (HP:0007260)3.16870531
24Nephronophthisis (HP:0000090)3.05276712
2511 pairs of ribs (HP:0000878)2.94331390
26Morphological abnormality of the inner ear (HP:0011390)2.91578617
27Cerebellar dysplasia (HP:0007033)2.82151697
28Progressive inability to walk (HP:0002505)2.74205929
29Brittle hair (HP:0002299)2.74147663
30Duplicated collecting system (HP:0000081)2.72005864
31Bronchomalacia (HP:0002780)2.60835282
32Stage 5 chronic kidney disease (HP:0003774)2.59857662
33Abnormal ciliary motility (HP:0012262)2.56907892
34Increased cerebral lipofuscin (HP:0011813)2.54980794
35Abnormality of the renal cortex (HP:0011035)2.53005427
36Hypoalbuminemia (HP:0003073)2.52362119
37Abnormal albumin level (HP:0012116)2.52362119
38Abnormality of dental color (HP:0011073)2.50380090
39Portal hypertension (HP:0001409)2.50171084
40Abnormal respiratory epithelium morphology (HP:0012253)2.46594808
41Abnormal respiratory motile cilium morphology (HP:0005938)2.46594808
42Abolished electroretinogram (ERG) (HP:0000550)2.46237640
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45395726
44Abnormality of alanine metabolism (HP:0010916)2.45395726
45Hyperalaninemia (HP:0003348)2.45395726
46Breast hypoplasia (HP:0003187)2.44753341
47Attenuation of retinal blood vessels (HP:0007843)2.44261332
48Amelogenesis imperfecta (HP:0000705)2.43827841
49Pancreatic fibrosis (HP:0100732)2.42682117
50Abnormality of the renal collecting system (HP:0004742)2.40456135
51Partial agenesis of the corpus callosum (HP:0001338)2.39371403
52Reticulocytopenia (HP:0001896)2.38704661
53Large for gestational age (HP:0001520)2.37125051
54Abnormality of the renal medulla (HP:0100957)2.34730271
55Abnormality of the pons (HP:0007361)2.32057894
56Severe muscular hypotonia (HP:0006829)2.31856584
57Abnormality of the hepatic vasculature (HP:0006707)2.29690214
58Morphological abnormality of the pyramidal tract (HP:0002062)2.22795319
59Progressive cerebellar ataxia (HP:0002073)2.22480429
60Non-midline cleft lip (HP:0100335)2.22268652
61Clumsiness (HP:0002312)2.21959647
62Tubulointerstitial abnormality (HP:0001969)2.20975904
63Redundant skin (HP:0001582)2.20920390
64Occipital encephalocele (HP:0002085)2.20620573
65Cystic liver disease (HP:0006706)2.19659247
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17133047
67Morphological abnormality of the middle ear (HP:0008609)2.15550010
68Mesangial abnormality (HP:0001966)2.14024196
69Optic nerve hypoplasia (HP:0000609)2.10459825
70Thyroid-stimulating hormone excess (HP:0002925)2.09900354
71Hypophosphatemic rickets (HP:0004912)2.08085618
72Trigonocephaly (HP:0000243)2.05517421
73Polydipsia (HP:0001959)2.04587679
74Abnormal drinking behavior (HP:0030082)2.04587679
75Abnormal hair laboratory examination (HP:0003328)2.03306998
76Abnormality of DNA repair (HP:0003254)2.02975506
77Hyperkalemia (HP:0002153)2.01185009
78Abnormality of B cell number (HP:0010975)1.97346760
79Hypoplasia of the pons (HP:0012110)1.96147892
80Abnormal respiratory motile cilium physiology (HP:0012261)1.91139406
81Bilateral sensorineural hearing impairment (HP:0008619)1.91107264
82Congenital, generalized hypertrichosis (HP:0004540)1.91059823
83Congenital sensorineural hearing impairment (HP:0008527)1.90471233
84Progressive hearing impairment (HP:0001730)1.89635683
85Bony spicule pigmentary retinopathy (HP:0007737)1.85911018
86Abnormal hemoglobin (HP:0011902)1.81897522
87Facial diplegia (HP:0001349)1.79362269
88Pendular nystagmus (HP:0012043)1.77984642
89Conical tooth (HP:0000698)1.77954865
90Abnormal number of erythroid precursors (HP:0012131)1.76817866
91Prominent supraorbital ridges (HP:0000336)1.76637200
92Increased circulating renin level (HP:0000848)1.75987448
93Increased corneal curvature (HP:0100692)1.74769905
94Keratoconus (HP:0000563)1.74769905
95Visual hallucinations (HP:0002367)1.74268241
96Hypoplastic ilia (HP:0000946)1.73813807
97Retrobulbar optic neuritis (HP:0100654)1.72672989
98Optic neuritis (HP:0100653)1.72672989
99Bile duct proliferation (HP:0001408)1.72184782
100Abnormal biliary tract physiology (HP:0012439)1.72184782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK25.63850187
2PLK44.32454866
3WNK44.25339124
4PNCK3.87024884
5DAPK23.51378830
6IRAK13.46900792
7TSSK62.62646436
8TAOK32.39362958
9INSRR2.39025437
10TXK2.32210774
11STK392.26170442
12PIK3CG2.15210879
13ZAK1.91805314
14WEE11.88324274
15PTK2B1.77237891
16MAPKAPK31.76169748
17PLK21.74217655
18ADRBK11.71823325
19ACVR1B1.60311493
20MAPKAPK51.55390494
21MAPK151.53434148
22DYRK31.48573415
23FRK1.46806403
24GRK61.41578401
25BRD41.40909003
26OXSR11.39149078
27MAP3K91.32309284
28PIK3CA1.30506891
29WNK11.29634607
30TYRO31.28661021
31BMPR1B1.27939241
32BMPR21.27579318
33TGFBR11.27520049
34TIE11.23597924
35NEK21.23107462
36MUSK1.14256623
37GRK11.11276544
38MARK31.09021829
39IRAK31.05850505
40TRPM71.04723489
41NEK61.02518820
42CAMK1G0.96580691
43TLK10.93480444
44BCKDK0.89124649
45MELK0.88168056
46NTRK30.86244912
47LATS20.77759821
48MAP2K20.76087130
49IKBKB0.75508475
50CDK120.70854016
51STK110.70559030
52VRK10.64525718
53CHUK0.63495830
54PKN10.60784496
55PDK10.60261413
56SIK20.59075334
57STK30.57998887
58PINK10.54691134
59MAPK130.53494509
60MAP2K10.52456722
61CAMK1D0.52140505
62KIT0.52022316
63EEF2K0.51284139
64CSF1R0.51005401
65PRKCG0.49817585
66CDK30.47710449
67NUAK10.45921140
68PRKCE0.45122720
69RPS6KA60.45065713
70PIM10.43031067
71SGK20.42896171
72PRKCQ0.42812610
73PDPK10.41860188
74MATK0.40634304
75NLK0.36373514
76TNIK0.36285465
77RIPK40.35267198
78MAP2K60.30032090
79BMX0.29422261
80MAPK110.28527274
81PAK20.27447983
82CAMKK10.26727059
83BRSK20.24786505
84SGK4940.22516908
85SGK2230.22516908
86SYK0.22211363
87ERBB20.22019953
88TEC0.20901910
89MAPK10.20058220
90CDC70.19681640
91MAP4K10.19664082
92PRKCH0.18808136
93IGF1R0.18520595
94PRKAA10.18016569
95PRKACA0.17575198
96RPS6KA50.17090500
97MAPK30.17041505
98STK240.16923338
99PRKAA20.15065846
100PRKG10.15064722

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.79598040
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.46117524
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.40378179
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.23840762
5Linoleic acid metabolism_Homo sapiens_hsa005913.09622502
6Nitrogen metabolism_Homo sapiens_hsa009103.04732340
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86670184
8Fatty acid biosynthesis_Homo sapiens_hsa000612.72924430
9Vitamin digestion and absorption_Homo sapiens_hsa049772.34802624
10Selenocompound metabolism_Homo sapiens_hsa004502.33703493
11ABC transporters_Homo sapiens_hsa020102.31145766
12Phototransduction_Homo sapiens_hsa047442.17586505
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15384738
14Ether lipid metabolism_Homo sapiens_hsa005651.94231258
15Tryptophan metabolism_Homo sapiens_hsa003801.77443846
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74860329
17Olfactory transduction_Homo sapiens_hsa047401.73607942
18Caffeine metabolism_Homo sapiens_hsa002321.71486058
19Arachidonic acid metabolism_Homo sapiens_hsa005901.69519161
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43312054
21Morphine addiction_Homo sapiens_hsa050321.41377371
22Taste transduction_Homo sapiens_hsa047421.41050577
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37721186
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35201140
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28673422
26Nicotine addiction_Homo sapiens_hsa050331.28606228
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27813858
28Serotonergic synapse_Homo sapiens_hsa047261.26077327
29Fat digestion and absorption_Homo sapiens_hsa049751.21705267
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.20849703
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17776953
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17673845
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.17665114
34Chemical carcinogenesis_Homo sapiens_hsa052041.14212729
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.14173712
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13672042
37Peroxisome_Homo sapiens_hsa041461.06945805
38Retinol metabolism_Homo sapiens_hsa008301.06195918
39Glutamatergic synapse_Homo sapiens_hsa047241.04871091
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.04141935
41Sulfur relay system_Homo sapiens_hsa041221.03872521
42Ovarian steroidogenesis_Homo sapiens_hsa049131.00629732
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.00591698
44Bile secretion_Homo sapiens_hsa049760.93845071
45Glycerolipid metabolism_Homo sapiens_hsa005610.88828311
46Circadian entrainment_Homo sapiens_hsa047130.86739267
47Primary immunodeficiency_Homo sapiens_hsa053400.82544147
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80083701
49GABAergic synapse_Homo sapiens_hsa047270.76230658
50Sphingolipid metabolism_Homo sapiens_hsa006000.75328424
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74074198
52Mineral absorption_Homo sapiens_hsa049780.72350405
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71352400
54Basal transcription factors_Homo sapiens_hsa030220.70315849
55Fatty acid degradation_Homo sapiens_hsa000710.70073890
56Fanconi anemia pathway_Homo sapiens_hsa034600.68573931
57One carbon pool by folate_Homo sapiens_hsa006700.66705101
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66572531
59Calcium signaling pathway_Homo sapiens_hsa040200.66496909
60PPAR signaling pathway_Homo sapiens_hsa033200.66364477
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64601436
62Homologous recombination_Homo sapiens_hsa034400.62096183
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.60225675
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59732951
65MAPK signaling pathway_Homo sapiens_hsa040100.58756396
66beta-Alanine metabolism_Homo sapiens_hsa004100.58362470
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.57124066
68Platelet activation_Homo sapiens_hsa046110.56606770
69Ribosome_Homo sapiens_hsa030100.55265455
70Tyrosine metabolism_Homo sapiens_hsa003500.54088300
71Insulin secretion_Homo sapiens_hsa049110.52186021
72Protein digestion and absorption_Homo sapiens_hsa049740.50247056
73Salivary secretion_Homo sapiens_hsa049700.47686278
74Basal cell carcinoma_Homo sapiens_hsa052170.47611424
75Melanoma_Homo sapiens_hsa052180.46582985
76Phenylalanine metabolism_Homo sapiens_hsa003600.46107853
77Gastric acid secretion_Homo sapiens_hsa049710.45077750
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.43673599
79Pancreatic secretion_Homo sapiens_hsa049720.42384991
80Renin-angiotensin system_Homo sapiens_hsa046140.41725915
81Fatty acid metabolism_Homo sapiens_hsa012120.41538441
82Histidine metabolism_Homo sapiens_hsa003400.41236186
83Cholinergic synapse_Homo sapiens_hsa047250.41034077
84Long-term depression_Homo sapiens_hsa047300.39694856
85Starch and sucrose metabolism_Homo sapiens_hsa005000.39600623
86Ras signaling pathway_Homo sapiens_hsa040140.39496236
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36656673
88cAMP signaling pathway_Homo sapiens_hsa040240.36285336
89Legionellosis_Homo sapiens_hsa051340.35868632
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32231858
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31269127
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31237180
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27783862
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27377091
95Lysosome_Homo sapiens_hsa041420.27028864
96Metabolic pathways_Homo sapiens_hsa011000.26965860
97Bladder cancer_Homo sapiens_hsa052190.26616868
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25697968
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22146047
100Arginine and proline metabolism_Homo sapiens_hsa003300.22102462

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