GULP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.70274828
2collagen fibril organization (GO:0030199)5.38467178
3protein heterotrimerization (GO:0070208)5.23281863
4bone trabecula formation (GO:0060346)4.97101824
5sequestering of extracellular ligand from receptor (GO:0035581)4.64631162
6mesenchymal-epithelial cell signaling (GO:0060638)4.31609919
7dermatan sulfate biosynthetic process (GO:0030208)4.30558057
8negative regulation of chondrocyte differentiation (GO:0032331)4.22315954
9L-serine metabolic process (GO:0006563)4.16510223
10establishment of integrated proviral latency (GO:0075713)4.10320410
11regulation of gene silencing by RNA (GO:0060966)4.05039374
12regulation of posttranscriptional gene silencing (GO:0060147)4.05039374
13regulation of gene silencing by miRNA (GO:0060964)4.05039374
14metanephric mesenchyme development (GO:0072075)4.03539659
15dermatan sulfate metabolic process (GO:0030205)3.98763906
16chromatin remodeling at centromere (GO:0031055)3.98131565
17axon extension involved in axon guidance (GO:0048846)3.92069725
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.92069725
19regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.87702314
20kidney mesenchyme development (GO:0072074)3.84417520
21CENP-A containing nucleosome assembly (GO:0034080)3.82305451
22outer ear morphogenesis (GO:0042473)3.76364267
23blood vessel maturation (GO:0001955)3.50692724
24pre-miRNA processing (GO:0031054)3.48522314
25craniofacial suture morphogenesis (GO:0097094)3.45843294
26glomerular basement membrane development (GO:0032836)3.45021466
27regulation of non-canonical Wnt signaling pathway (GO:2000050)3.44690344
28retina vasculature morphogenesis in camera-type eye (GO:0061299)3.40739198
29extracellular regulation of signal transduction (GO:1900115)3.38416019
30extracellular negative regulation of signal transduction (GO:1900116)3.38416019
31anterior/posterior axis specification, embryo (GO:0008595)3.38162990
32histone exchange (GO:0043486)3.35550200
33regulation of mesenchymal cell proliferation (GO:0010464)3.34825082
34positive regulation of mesenchymal cell proliferation (GO:0002053)3.34279976
35collagen metabolic process (GO:0032963)3.34248681
36negative regulation of cartilage development (GO:0061037)3.34083199
37smooth muscle tissue development (GO:0048745)3.32581172
38extracellular fibril organization (GO:0043206)3.30001459
39chondrocyte development (GO:0002063)3.29786220
40collagen catabolic process (GO:0030574)3.28144220
41middle ear morphogenesis (GO:0042474)3.25270062
42protein localization to kinetochore (GO:0034501)3.24192763
43embryonic cranial skeleton morphogenesis (GO:0048701)3.19338952
44notochord development (GO:0030903)3.18958138
45definitive hemopoiesis (GO:0060216)3.17787812
46endodermal cell differentiation (GO:0035987)3.17660483
47regulation of helicase activity (GO:0051095)3.16072298
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.15309118
49multicellular organismal macromolecule metabolic process (GO:0044259)3.12792041
50mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12243284
51mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12243284
52DNA replication-independent nucleosome assembly (GO:0006336)3.11860278
53DNA replication-independent nucleosome organization (GO:0034724)3.11860278
54ganglion development (GO:0061548)3.11177676
55cell proliferation involved in kidney development (GO:0072111)3.09683582
56glial cell migration (GO:0008347)3.09507197
57glomerular filtration (GO:0003094)3.09355737
58regulation of cell fate specification (GO:0042659)3.09200774
59cell adhesion mediated by integrin (GO:0033627)3.05968274
60protein localization to cell surface (GO:0034394)3.03399205
61paraxial mesoderm development (GO:0048339)3.03387833
62mitotic metaphase plate congression (GO:0007080)3.03375701
63regulation of heart morphogenesis (GO:2000826)3.03181019
64regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.02907890
65hippo signaling (GO:0035329)3.01934021
66neural crest cell development (GO:0014032)3.00221287
67establishment of viral latency (GO:0019043)2.99377860
68endocardial cushion development (GO:0003197)2.99209333
69negative regulation of translation, ncRNA-mediated (GO:0040033)2.99132180
70regulation of translation, ncRNA-mediated (GO:0045974)2.99132180
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99132180
72negative regulation of embryonic development (GO:0045992)2.98280800
73negative regulation of sister chromatid segregation (GO:0033046)2.98094288
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98094288
75negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98094288
76negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98094288
77negative regulation of mitotic sister chromatid separation (GO:2000816)2.98094288
78cell proliferation involved in metanephros development (GO:0072203)2.96916566
79lymph vessel development (GO:0001945)2.95847815
80multicellular organismal catabolic process (GO:0044243)2.95242972
81heterochromatin organization (GO:0070828)2.93476504
82nuclear pore complex assembly (GO:0051292)2.93474088
83multicellular organismal metabolic process (GO:0044236)2.93454318
84facial nerve structural organization (GO:0021612)2.92522137
85negative regulation of chromosome segregation (GO:0051985)2.92464248
86mesenchymal cell proliferation (GO:0010463)2.91534982
87negative regulation of stem cell proliferation (GO:2000647)2.90703027
88embryonic skeletal joint morphogenesis (GO:0060272)2.90452106
89embryonic forelimb morphogenesis (GO:0035115)2.89397826
90glomerulus development (GO:0032835)2.89344295
91fibril organization (GO:0097435)2.89248699
92lateral sprouting from an epithelium (GO:0060601)2.88825787
93cell migration involved in heart development (GO:0060973)2.88729728
94regulation of mitotic spindle checkpoint (GO:1903504)2.87858886
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87858886
96DNA replication checkpoint (GO:0000076)2.87737744
97DNA double-strand break processing (GO:0000729)2.87515417
98spindle checkpoint (GO:0031577)2.86788301
99lung-associated mesenchyme development (GO:0060484)2.86206545
100regulation of chondrocyte differentiation (GO:0032330)2.84941970
101metaphase plate congression (GO:0051310)2.84691236
102mesenchyme morphogenesis (GO:0072132)2.83956849
103wound healing, spreading of epidermal cells (GO:0035313)2.83216659
104cartilage morphogenesis (GO:0060536)2.83108393
105myelination in peripheral nervous system (GO:0022011)2.82835952
106peripheral nervous system axon ensheathment (GO:0032292)2.82835952
107endothelial cell morphogenesis (GO:0001886)2.82031208
108DNA damage response, detection of DNA damage (GO:0042769)2.81983077
109regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.81901396
110IMP biosynthetic process (GO:0006188)2.80630364
111protein complex localization (GO:0031503)2.79995492
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79891404
113cranial nerve structural organization (GO:0021604)2.79847657
114nuclear pore organization (GO:0006999)2.79214478
115renal filtration (GO:0097205)2.79206656
116mitotic spindle checkpoint (GO:0071174)2.78158421
117purine nucleobase biosynthetic process (GO:0009113)2.77717755
118prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.76641113
119keratan sulfate catabolic process (GO:0042340)2.75663393
120anatomical structure arrangement (GO:0048532)2.75224336
121cranial suture morphogenesis (GO:0060363)2.75188448
122peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.75088163
123positive regulation of cartilage development (GO:0061036)2.74023594
124mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73368493
125negative chemotaxis (GO:0050919)2.72427384
126epithelial to mesenchymal transition (GO:0001837)2.71798015
127artery development (GO:0060840)2.70933943
128regulation of centriole replication (GO:0046599)2.70203746
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70095582
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.70095582
131limb bud formation (GO:0060174)2.69740499
132mesenchymal cell development (GO:0014031)2.69500214
133serine family amino acid biosynthetic process (GO:0009070)2.68789421
134cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68502173
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.68033239
136extracellular matrix organization (GO:0030198)2.67794305
137extracellular matrix disassembly (GO:0022617)2.66496954
138extracellular structure organization (GO:0043062)2.66326976
139negative regulation of fatty acid transport (GO:2000192)2.65864854
140cell fate commitment involved in formation of primary germ layer (GO:0060795)2.65774569
141epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.64781482
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.64471840
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64471840
144lysine catabolic process (GO:0006554)2.64276521
145lysine metabolic process (GO:0006553)2.64276521
146regulation of cartilage development (GO:0061035)2.64127142
147dorsal/ventral axis specification (GO:0009950)2.63984535
148mesenchyme development (GO:0060485)2.63570250
149insulin-like growth factor receptor signaling pathway (GO:0048009)2.63546517
150non-recombinational repair (GO:0000726)2.63474058
151double-strand break repair via nonhomologous end joining (GO:0006303)2.63474058
152cardiac epithelial to mesenchymal transition (GO:0060317)2.63368612
153planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62247831
154forelimb morphogenesis (GO:0035136)2.62178773
155positive regulation of epithelial to mesenchymal transition (GO:0010718)2.61969983
156positive regulation of SMAD protein import into nucleus (GO:0060391)2.61601678
157negative regulation of catenin import into nucleus (GO:0035414)2.61386264
158mitotic spindle assembly checkpoint (GO:0007094)2.60842078
159ATP-dependent chromatin remodeling (GO:0043044)2.59997090
160IMP metabolic process (GO:0046040)2.59938529
161negative regulation of DNA-dependent DNA replication (GO:2000104)2.59765108
162negative regulation of mitosis (GO:0045839)2.58744384
163telomere maintenance via telomerase (GO:0007004)2.58322506
164regulation of mitotic sister chromatid separation (GO:0010965)2.58070670
165regulation of mitotic sister chromatid segregation (GO:0033047)2.58070670
166regulation of sister chromatid segregation (GO:0033045)2.58070670
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57449864
168DNA ligation (GO:0006266)2.57244206
169nucleobase biosynthetic process (GO:0046112)2.56723439
170spindle assembly checkpoint (GO:0071173)2.55281580
171convergent extension (GO:0060026)2.54422187
172response to X-ray (GO:0010165)2.51847480
173regulation of chromosome segregation (GO:0051983)2.51432627
174DNA replication-dependent nucleosome organization (GO:0034723)2.47441073
175DNA replication-dependent nucleosome assembly (GO:0006335)2.47441073
176regulation of cell fate commitment (GO:0010453)2.46416622
177protein localization to chromosome, centromeric region (GO:0071459)2.43663040
178female gonad development (GO:0008585)2.43365253
179mitotic G2/M transition checkpoint (GO:0044818)2.42865653
180kinetochore organization (GO:0051383)2.40054386
181regulation of nuclear cell cycle DNA replication (GO:0033262)2.39717905
182DNA strand elongation involved in DNA replication (GO:0006271)2.39715644
183regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38195591
184regulation of mesoderm development (GO:2000380)2.34954493
185negative regulation of DNA recombination (GO:0045910)2.34499035
186negative regulation of DNA repair (GO:0045738)2.34071675
187establishment of protein localization to mitochondrial membrane (GO:0090151)2.33305552
188presynaptic membrane assembly (GO:0097105)2.32629793
189negative regulation of nuclear division (GO:0051784)2.32567971
190ventricular cardiac muscle cell development (GO:0055015)2.32490028
191sister chromatid segregation (GO:0000819)2.32264225
192RNA-dependent DNA replication (GO:0006278)2.29815904
193mitotic sister chromatid segregation (GO:0000070)2.29631450
194DNA strand renaturation (GO:0000733)2.26801107
195DNA strand elongation (GO:0022616)2.26657774
196proteasome assembly (GO:0043248)2.26266035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.93088062
2E2F7_22180533_ChIP-Seq_HELA_Human4.37398393
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.34213410
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.09703821
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98383031
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.87609473
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72304893
8CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.71808549
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.71288633
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.63704423
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57014797
12* AR_21909140_ChIP-Seq_LNCAP_Human2.55080602
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49780372
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.44617932
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41954911
16GBX2_23144817_ChIP-Seq_PC3_Human2.37255263
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33285235
18* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.32710985
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27981127
20* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27271433
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24729259
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24337547
23* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23680754
24CJUN_26792858_Chip-Seq_BT549_Human2.19613436
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.18186314
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17331633
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.15010590
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.12855998
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11503873
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10606989
31ELK1_19687146_ChIP-ChIP_HELA_Human2.08048047
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.07561391
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02785255
34TP53_18474530_ChIP-ChIP_U2OS_Human2.01652800
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01306195
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01306195
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01306195
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.99974240
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99875203
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99875203
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.99288658
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.99013937
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.99013937
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.97350275
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93410126
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92590245
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.92127354
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86602559
49* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85498218
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.84189327
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83350329
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.82425929
53TP53_16413492_ChIP-PET_HCT116_Human1.82138626
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79334173
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76913211
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75724890
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.74729946
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74257313
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73877447
60BRD4_25478319_ChIP-Seq_HGPS_Human1.73005528
61ZNF274_21170338_ChIP-Seq_K562_Hela1.72536397
62AR_21572438_ChIP-Seq_LNCaP_Human1.72212619
63VDR_22108803_ChIP-Seq_LS180_Human1.71171084
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70818456
65FUS_26573619_Chip-Seq_HEK293_Human1.68484313
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68201356
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67602014
68* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65551349
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65082399
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62360696
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61997651
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59862870
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58185459
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57811278
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55289553
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52788980
77* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51558814
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50742767
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50458691
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50277924
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.48136062
82CLOCK_20551151_ChIP-Seq_293T_Human1.48095369
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.45603512
84* P300_19829295_ChIP-Seq_ESCs_Human1.45534408
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45409925
86IGF1R_20145208_ChIP-Seq_DFB_Human1.44616392
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43482909
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41979428
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.40508249
90EWS_26573619_Chip-Seq_HEK293_Human1.39822588
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39782417
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.38650650
93* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36182911
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36073620
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35858653
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35750132
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32678669
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32339344
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29927737
100* MYC_18940864_ChIP-ChIP_HL60_Human1.28525799
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28202377
102* SMAD4_21799915_ChIP-Seq_A2780_Human1.27068200
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26932986
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.26894765
105TTF2_22483619_ChIP-Seq_HELA_Human1.26027165
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.25359095
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25014138
108* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24946289
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23907620
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22687916
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22614940
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21301367
113TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21255483
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20385657
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20232127
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20127576
117* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20091086
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19958809
119ETS1_20019798_ChIP-Seq_JURKAT_Human1.19714454
120TP63_19390658_ChIP-ChIP_HaCaT_Human1.19416057
121MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19123746
122ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18209724
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17295001
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17278632
125TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16045712
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14292047
127IRF1_19129219_ChIP-ChIP_H3396_Human1.14085697
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14076604
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.13920626
130* ISL1_27105846_Chip-Seq_CPCs_Mouse1.13831409
131RING1B_27294783_Chip-Seq_NPCs_Mouse1.12458515
132GATA1_26923725_Chip-Seq_HPCs_Mouse1.11964556
133* FLI1_27457419_Chip-Seq_LIVER_Mouse1.11885298
134BCAT_22108803_ChIP-Seq_LS180_Human1.11822278
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10455312
136TAF15_26573619_Chip-Seq_HEK293_Human1.09693192
137POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08929391
138NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08685202
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08671846
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08671846
141ER_23166858_ChIP-Seq_MCF-7_Human1.07717606
142FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06576150
143* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06485364
144NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06173418
145* AHR_22903824_ChIP-Seq_MCF-7_Human1.05615199
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05068409
147SOX17_20123909_ChIP-Seq_XEN_Mouse1.04967154
148* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03764482
149EZH2_27294783_Chip-Seq_ESCs_Mouse1.03490649
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03004469
151GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01721734
152FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00871374
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00789808
154XRN2_22483619_ChIP-Seq_HELA_Human0.99368695
155ESR1_20079471_ChIP-ChIP_T-47D_Human0.99102543
156* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98219492
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97586295
158* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96418578
159* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96138786
160* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95462030
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95305257
162FOXP3_21729870_ChIP-Seq_TREG_Human0.95069445
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94742189
164RXR_22108803_ChIP-Seq_LS180_Human0.94632548
165* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94411930
166JUN_21703547_ChIP-Seq_K562_Human0.94308780
167* SOX9_26525672_Chip-Seq_HEART_Mouse0.94030581
168* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93917235
169* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93916004
170CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93784662
171* SOX2_20726797_ChIP-Seq_SW620_Human0.93769374
172PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92134557
173MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91430301
174THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89266897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.97732114
2MP0005503_abnormal_tendon_morphology5.15530814
3MP0005275_abnormal_skin_tensile4.30679765
4MP0004272_abnormal_basement_membrane3.59668738
5MP0005171_absent_coat_pigmentation2.96308696
6MP0003279_aneurysm2.77459774
7MP0003890_abnormal_embryonic-extraembry2.72837960
8MP0009384_cardiac_valve_regurgitation2.64950389
9MP0001958_emphysema2.61888443
10MP0006292_abnormal_olfactory_placode2.55061723
11MP0009250_abnormal_appendicular_skeleto2.46855717
12MP0005623_abnormal_meninges_morphology2.45430269
13MP0003693_abnormal_embryo_hatching2.43715647
14MP0004957_abnormal_blastocyst_morpholog2.42249047
15MP0003385_abnormal_body_wall2.25219054
16MP0010030_abnormal_orbit_morphology2.23124358
17MP0005508_abnormal_skeleton_morphology2.14033966
18MP0010094_abnormal_chromosome_stability2.10375429
19MP0003705_abnormal_hypodermis_morpholog2.09339945
20MP0008058_abnormal_DNA_repair2.03980555
21MP0008932_abnormal_embryonic_tissue2.00653417
22MP0002938_white_spotting1.88307058
23MP0002254_reproductive_system_inflammat1.85980645
24MP0002249_abnormal_larynx_morphology1.84484136
25MP0003111_abnormal_nucleus_morphology1.83345991
26MP0001879_abnormal_lymphatic_vessel1.80884030
27MP0000049_abnormal_middle_ear1.76996278
28MP0003937_abnormal_limbs/digits/tail_de1.74937637
29MP0009697_abnormal_copulation1.73992376
30MP0003942_abnormal_urinary_system1.73041232
31MP0002108_abnormal_muscle_morphology1.71448199
32MP0003718_maternal_effect1.67703633
33MP0003567_abnormal_fetal_cardiomyocyte1.66712996
34MP0008877_abnormal_DNA_methylation1.65262600
35MP0005367_renal/urinary_system_phenotyp1.63065864
36MP0000516_abnormal_urinary_system1.63065864
37MP0004133_heterotaxia1.61924817
38MP0003077_abnormal_cell_cycle1.61208792
39MP0003119_abnormal_digestive_system1.61118454
40MP0009672_abnormal_birth_weight1.59861197
41MP0005257_abnormal_intraocular_pressure1.59275489
42MP0002282_abnormal_trachea_morphology1.58940265
43MP0003941_abnormal_skin_development1.56892097
44MP0006054_spinal_hemorrhage1.55633206
45MP0008057_abnormal_DNA_replication1.54705702
46MP0004134_abnormal_chest_morphology1.52710174
47MP0000534_abnormal_ureter_morphology1.52595165
48MP0000579_abnormal_nail_morphology1.52557708
49MP0010368_abnormal_lymphatic_system1.51741745
50MP0002084_abnormal_developmental_patter1.51553458
51MP0009053_abnormal_anal_canal1.50771768
52MP0006072_abnormal_retinal_apoptosis1.50122437
53MP0002060_abnormal_skin_morphology1.48764913
54MP0002085_abnormal_embryonic_tissue1.42589820
55MP0003755_abnormal_palate_morphology1.41728342
56MP0002932_abnormal_joint_morphology1.40633165
57MP0000537_abnormal_urethra_morphology1.37907200
58MP0003136_yellow_coat_color1.34930444
59MP0000733_abnormal_muscle_development1.33915890
60MP0000566_synostosis1.31347450
61MP0001299_abnormal_eye_distance/1.30493804
62MP0000428_abnormal_craniofacial_morphol1.30155352
63MP0005248_abnormal_Harderian_gland1.29875463
64MP0002295_abnormal_pulmonary_circulatio1.29320394
65MP0002233_abnormal_nose_morphology1.27088008
66MP0000647_abnormal_sebaceous_gland1.26604119
67MP0009703_decreased_birth_body1.25812615
68MP0000163_abnormal_cartilage_morphology1.25161573
69MP0008007_abnormal_cellular_replicative1.21448047
70MP0008789_abnormal_olfactory_epithelium1.21035819
71MP0003935_abnormal_craniofacial_develop1.20726307
72MP0000569_abnormal_digit_pigmentation1.19882902
73MP0000767_abnormal_smooth_muscle1.19640123
74MP0002115_abnormal_skeleton_extremities1.19514967
75MP0000762_abnormal_tongue_morphology1.19297343
76MP0002109_abnormal_limb_morphology1.17377589
77MP0001672_abnormal_embryogenesis/_devel1.17346359
78MP0005380_embryogenesis_phenotype1.17346359
79MP0002116_abnormal_craniofacial_bone1.17011236
80MP0001730_embryonic_growth_arrest1.16154436
81MP0005187_abnormal_penis_morphology1.12585809
82MP0002896_abnormal_bone_mineralization1.11921755
83MP0003861_abnormal_nervous_system1.10740992
84MP0001529_abnormal_vocalization1.09718878
85MP0001188_hyperpigmentation1.09198999
86MP0004197_abnormal_fetal_growth/weight/1.09141364
87MP0002177_abnormal_outer_ear1.08639333
88MP0000432_abnormal_head_morphology1.08127831
89MP0003115_abnormal_respiratory_system1.06033233
90MP0003950_abnormal_plasma_membrane1.05662357
91MP0002751_abnormal_autonomic_nervous1.05650874
92MP0001697_abnormal_embryo_size1.04584630
93MP0003123_paternal_imprinting1.03083932
94MP0002113_abnormal_skeleton_development1.02836089
95MP0005390_skeleton_phenotype1.01940569
96MP0000778_abnormal_nervous_system1.01235427
97MP0003984_embryonic_growth_retardation1.01068220
98MP0003091_abnormal_cell_migration0.99822019
99MP0002088_abnormal_embryonic_growth/wei0.99649701
100MP0009379_abnormal_foot_pigmentation0.99335892
101MP0005391_vision/eye_phenotype0.98656959
102MP0005023_abnormal_wound_healing0.98382411
103MP0001485_abnormal_pinna_reflex0.96927842
104MP0003045_fibrosis0.96261013
105MP0005197_abnormal_uvea_morphology0.94821252
106MP0005394_taste/olfaction_phenotype0.94410581
107MP0005499_abnormal_olfactory_system0.94410581
108MP0000631_abnormal_neuroendocrine_gland0.94170269
109MP0000350_abnormal_cell_proliferation0.92282473
110MP0001293_anophthalmia0.92114464
111MP0003566_abnormal_cell_adhesion0.91846156
112MP0003122_maternal_imprinting0.91619109
113MP0002697_abnormal_eye_size0.91551257
114MP0002089_abnormal_postnatal_growth/wei0.90016467
115MP0002168_other_aberrant_phenotype0.89912656
116MP0000383_abnormal_hair_follicle0.89551150
117MP0002653_abnormal_ependyma_morphology0.88263606
118MP0001542_abnormal_bone_strength0.85415897
119MP0002114_abnormal_axial_skeleton0.85340738
120MP0005595_abnormal_vascular_smooth0.84957044
121MP0000372_irregular_coat_pigmentation0.84519854
122MP0002111_abnormal_tail_morphology0.84382516
123MP0005377_hearing/vestibular/ear_phenot0.84009275
124MP0003878_abnormal_ear_physiology0.84009275
125MP0003011_delayed_dark_adaptation0.83898312
126MP0002090_abnormal_vision0.83370552
127MP0005253_abnormal_eye_physiology0.83158223
128MP0000751_myopathy0.82777590
129MP0002102_abnormal_ear_morphology0.81106914
130MP0002080_prenatal_lethality0.80128645
131MP0004858_abnormal_nervous_system0.77850840
132MP0001346_abnormal_lacrimal_gland0.76925133
133MP0002133_abnormal_respiratory_system0.76882670
134MP0005388_respiratory_system_phenotype0.76882670
135MP0001614_abnormal_blood_vessel0.76805280
136MP0002128_abnormal_blood_circulation0.76310151
137MP0001286_abnormal_eye_development0.75599320
138MP0010678_abnormal_skin_adnexa0.73773277
139MP0006138_congestive_heart_failure0.72982085
140MP0003938_abnormal_ear_development0.72272438
141MP0001177_atelectasis0.71747807
142MP0002736_abnormal_nociception_after0.71744695
143MP0001324_abnormal_eye_pigmentation0.71358410
144MP0010307_abnormal_tumor_latency0.71313864
145MP0002092_abnormal_eye_morphology0.71181381
146MP0003283_abnormal_digestive_organ0.70194336
147MP0001340_abnormal_eyelid_morphology0.69986965
148MP0002925_abnormal_cardiovascular_devel0.69829730
149MP0005193_abnormal_anterior_eye0.69311651
150MP0001270_distended_abdomen0.66885868
151MP0001175_abnormal_lung_morphology0.66266263
152MP0003315_abnormal_perineum_morphology0.65698462
153MP0003121_genomic_imprinting0.62019033
154MP0000467_abnormal_esophagus_morphology0.61168660
155MP0000013_abnormal_adipose_tissue0.61081496
156MP0005408_hypopigmentation0.60755409
157MP0010352_gastrointestinal_tract_polyps0.58826829
158MP0001243_abnormal_dermal_layer0.57844668

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.50945130
2Premature rupture of membranes (HP:0001788)6.02618373
3Aortic dissection (HP:0002647)4.35026861
4Soft skin (HP:0000977)4.06466276
5Colon cancer (HP:0003003)3.92090338
6Abnormality of the labia minora (HP:0012880)3.84118205
7Shallow orbits (HP:0000586)3.82094368
8Abnormality of dentin (HP:0010299)3.81419303
9Atrophic scars (HP:0001075)3.78672544
10Follicular hyperkeratosis (HP:0007502)3.76794270
11Ankle contracture (HP:0006466)3.76247185
12Broad metatarsal (HP:0001783)3.75345771
13Cervical subluxation (HP:0003308)3.57131219
14Neonatal short-limb short stature (HP:0008921)3.53301476
15Septo-optic dysplasia (HP:0100842)3.36954162
16Aortic aneurysm (HP:0004942)3.31794206
17Fragile skin (HP:0001030)3.21360099
18Bladder diverticulum (HP:0000015)3.18229784
19Dilatation of the ascending aorta (HP:0005111)2.93538361
20Spinal rigidity (HP:0003306)2.92441610
21Wormian bones (HP:0002645)2.83619057
22Overgrowth (HP:0001548)2.80439469
23Spinal cord lesions (HP:0100561)2.70592612
24Syringomyelia (HP:0003396)2.70592612
25Asymmetry of the thorax (HP:0001555)2.69330308
26Abnormal lung lobation (HP:0002101)2.69231454
27Stenosis of the external auditory canal (HP:0000402)2.68371832
28Blue sclerae (HP:0000592)2.63171324
29Morphological abnormality of the middle ear (HP:0008609)2.62148843
30Keratoconus (HP:0000563)2.59345093
31Increased corneal curvature (HP:0100692)2.59345093
32Mitral valve prolapse (HP:0001634)2.56644230
33Biconcave vertebral bodies (HP:0004586)2.54680957
34Peritonitis (HP:0002586)2.53410046
35Bell-shaped thorax (HP:0001591)2.53063708
36Cerebral aneurysm (HP:0004944)2.51294965
37Wrist flexion contracture (HP:0001239)2.49712888
38Vascular tortuosity (HP:0004948)2.48921435
39Type 1 muscle fiber predominance (HP:0003803)2.48783273
40Mesomelia (HP:0003027)2.43477622
41Bifid tongue (HP:0010297)2.43445514
42Ulnar claw (HP:0001178)2.42806018
43Hepatoblastoma (HP:0002884)2.41740550
44Short 4th metacarpal (HP:0010044)2.41523226
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41523226
46Bilateral microphthalmos (HP:0007633)2.41089823
47Birth length less than 3rd percentile (HP:0003561)2.39313647
48Hypoplasia of the iris (HP:0007676)2.38786410
49Joint laxity (HP:0001388)2.33779368
50Vertebral compression fractures (HP:0002953)2.32548885
51Absent septum pellucidum (HP:0001331)2.31093341
52Meckel diverticulum (HP:0002245)2.30586460
53Coronal craniosynostosis (HP:0004440)2.29595362
54Chorioretinal atrophy (HP:0000533)2.27342776
55Chromsome breakage (HP:0040012)2.26516109
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25964362
57Cortical dysplasia (HP:0002539)2.25134023
58Nephroblastoma (Wilms tumor) (HP:0002667)2.24891771
59Aplasia/Hypoplasia of the sternum (HP:0006714)2.23317910
60Absent radius (HP:0003974)2.21440026
61Anophthalmia (HP:0000528)2.21081522
62Broad ribs (HP:0000885)2.19443862
63Abnormality of the septum pellucidum (HP:0007375)2.19375127
64Microglossia (HP:0000171)2.19152631
65Hyperglycinemia (HP:0002154)2.19068578
66Abnormality of the ileum (HP:0001549)2.18834883
67Ependymoma (HP:0002888)2.16345112
68Rhabdomyosarcoma (HP:0002859)2.15984438
69Embryonal renal neoplasm (HP:0011794)2.15190773
70Wide anterior fontanel (HP:0000260)2.14848280
71Spastic diplegia (HP:0001264)2.13332496
72Absent forearm bone (HP:0003953)2.12808423
73Aplasia involving forearm bones (HP:0009822)2.12808423
74Infantile muscular hypotonia (HP:0008947)2.12656765
75Maternal diabetes (HP:0009800)2.10762827
76Choanal stenosis (HP:0000452)2.09785406
77Hyperextensible skin (HP:0000974)2.09100844
78Genu recurvatum (HP:0002816)2.06987155
79Esophageal atresia (HP:0002032)2.06842902
80Short middle phalanx of the 5th finger (HP:0004220)2.06284731
81Narrow nasal bridge (HP:0000446)2.05797895
82Arterial tortuosity (HP:0005116)2.04936145
83Upper limb muscle weakness (HP:0003484)2.04442437
84Optic nerve hypoplasia (HP:0000609)2.03712424
85Abnormal delivery (HP:0001787)2.03664824
86Aplasia involving bones of the extremities (HP:0009825)2.03432115
87Aplasia involving bones of the upper limbs (HP:0009823)2.03432115
88Aplasia of the phalanges of the hand (HP:0009802)2.03432115
89Glioma (HP:0009733)2.02285523
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01082354
91Hyperglycinuria (HP:0003108)2.00301494
92Abnormality of glycine metabolism (HP:0010895)1.98100917
93Abnormality of serine family amino acid metabolism (HP:0010894)1.98100917
94Vaginal atresia (HP:0000148)1.97547671
95Facial cleft (HP:0002006)1.96886155
96Cutaneous finger syndactyly (HP:0010554)1.96563514
97Myelomeningocele (HP:0002475)1.96531291
98Partial duplication of thumb phalanx (HP:0009944)1.96436178
99Pancreatic fibrosis (HP:0100732)1.96213241
100Bowel diverticulosis (HP:0005222)1.95158695
101Abnormality of the 4th metacarpal (HP:0010012)1.95037242
102Triphalangeal thumb (HP:0001199)1.94940524
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.94757407
104Genital tract atresia (HP:0001827)1.94726524
105Abnormality of chromosome stability (HP:0003220)1.94621219
106Pulmonary artery stenosis (HP:0004415)1.93808060
107Medulloblastoma (HP:0002885)1.93416053
108Short hallux (HP:0010109)1.93293430
109Breech presentation (HP:0001623)1.92548513
110Chronic bronchitis (HP:0004469)1.91380545
111Partial duplication of the phalanx of hand (HP:0009999)1.91062399
112Osteolytic defects of the hand bones (HP:0009699)1.90314616
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.90314616
114Broad long bones (HP:0005622)1.90078036
115Abnormality of the phalanges of the hallux (HP:0010057)1.90050762
116Aplasia/Hypoplasia of the breasts (HP:0010311)1.88062077
117Segmental peripheral demyelination/remyelination (HP:0003481)1.86939258
118Buphthalmos (HP:0000557)1.86930590
119Absent eyebrow (HP:0002223)1.86157402
120Breast aplasia (HP:0100783)1.86152787
121White forelock (HP:0002211)1.85659063
122Cutaneous syndactyly (HP:0012725)1.85339873
123True hermaphroditism (HP:0010459)1.85194849
124Hypoplastic female external genitalia (HP:0012815)1.83441488
125Subacute progressive viral hepatitis (HP:0006572)1.82612894
126Abnormality of the acetabulum (HP:0003170)1.82413046
127Abnormality of serum amino acid levels (HP:0003112)1.81339609
128Preaxial foot polydactyly (HP:0001841)1.80902456
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80811053
130Abnormality of the anterior chamber (HP:0000593)1.80571936
131Patchy hypopigmentation of hair (HP:0011365)1.80517957
132Deviation of the hallux (HP:0010051)1.79367645
133Vitreoretinal degeneration (HP:0000655)1.79021298
134Reticulocytopenia (HP:0001896)1.78580812
135Scapular winging (HP:0003691)1.78443066
136Mitral regurgitation (HP:0001653)1.77966437
137Slender build (HP:0001533)1.77660064
138Limited hip movement (HP:0008800)1.77482571
139Ectopia lentis (HP:0001083)1.77145704
140Tibial bowing (HP:0002982)1.76579545
141Duplication of thumb phalanx (HP:0009942)1.76516857
142Femoral bowing (HP:0002980)1.76493911
143Gastrointestinal atresia (HP:0002589)1.76420092
144Osteoarthritis (HP:0002758)1.76203473
145Labial hypoplasia (HP:0000066)1.75160692
146Supernumerary spleens (HP:0009799)1.73688257
147Tarsal synostosis (HP:0008368)1.73368789
148Venous insufficiency (HP:0005293)1.73323967
149Decreased skull ossification (HP:0004331)1.72328159
150Preaxial hand polydactyly (HP:0001177)1.71992934
151Abnormality of the astrocytes (HP:0100707)1.71396354
152Astrocytoma (HP:0009592)1.71396354
153Broad foot (HP:0001769)1.71394882
154Aplasia/hypoplasia of the humerus (HP:0006507)1.70920125
155Renal hypoplasia (HP:0000089)1.70689156
156Neoplasm of the colon (HP:0100273)1.70485503
157Fibular aplasia (HP:0002990)1.70322245
158Biliary tract neoplasm (HP:0100574)1.69639258
159Intestinal atresia (HP:0011100)1.69429776
160Duodenal stenosis (HP:0100867)1.69259234
161Small intestinal stenosis (HP:0012848)1.69259234
162Short humerus (HP:0005792)1.69223950
163Pancreatic cysts (HP:0001737)1.68857319
164Camptodactyly of toe (HP:0001836)1.68033783
165Spondylolisthesis (HP:0003302)1.67976332
166Abnormality of the duodenum (HP:0002246)1.66971326
167Abnormality of the parietal bone (HP:0002696)1.66581086
168Elbow flexion contracture (HP:0002987)1.66545893
169Aplasia/Hypoplasia of the hallux (HP:0008362)1.66299908
170Ectopic kidney (HP:0000086)1.65889365
171Flared iliac wings (HP:0002869)1.65836747
172Midline defect of the nose (HP:0004122)1.65465956
173Aqueductal stenosis (HP:0002410)1.64698446
174Abnormality of the middle phalanges of the toes (HP:0010183)1.64673702
175Median cleft lip (HP:0000161)1.64609876
176Absent frontal sinuses (HP:0002688)1.64595720
177Natal tooth (HP:0000695)1.64080135
178Synostosis involving bones of the lower limbs (HP:0009138)1.63486463
179Synostosis involving bones of the feet (HP:0009140)1.63486463
180Micropenis (HP:0000054)1.63401453
181Hallux valgus (HP:0001822)1.62890799
182Dandy-Walker malformation (HP:0001305)1.62718677
183Aplasia cutis congenita (HP:0001057)1.62640414
184Abnormality of abdominal situs (HP:0011620)1.62169173
185Abdominal situs inversus (HP:0003363)1.62169173
186Scrotal hypoplasia (HP:0000046)1.60944033
187Increased nuchal translucency (HP:0010880)1.60485631
188Sloping forehead (HP:0000340)1.57861413
189Postaxial hand polydactyly (HP:0001162)1.57539279
190Hemivertebrae (HP:0002937)1.57357605
191Abnormality of the pons (HP:0007361)1.56888098
192Nephronophthisis (HP:0000090)1.56887907
193Anal stenosis (HP:0002025)1.56281520
194Sclerocornea (HP:0000647)1.53888574

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.31563883
2MKNK23.13862651
3LATS13.09307908
4BUB13.00016022
5MKNK12.95257771
6TSSK62.93243549
7EPHB22.87180425
8TTK2.79938663
9CDC72.74079103
10FRK2.73831720
11PDGFRA2.58428366
12PIK3CA2.40612172
13EPHA32.37515335
14CASK2.37054747
15ERBB32.36746973
16ZAK2.33852401
17SIK12.32540102
18TAF12.30215591
19SRPK12.14532168
20TTN2.10692756
21PLK42.09877803
22WNK32.08682863
23NUAK12.03473133
24BMPR1B2.03142760
25WEE12.02192040
26VRK21.99620418
27TRIM281.97314025
28TGFBR21.97055085
29MST41.90887132
30TIE11.85104470
31FER1.82796842
32NEK11.80602575
33TRPM71.74174573
34PNCK1.69436530
35PAK21.68658317
36AKT31.67732089
37STK31.55713781
38PLK21.48794907
39STK38L1.44055485
40TGFBR11.43512211
41ACVR1B1.35460317
42ROCK11.35210784
43MYLK1.34034560
44VRK11.33642461
45EIF2AK21.33197924
46DYRK31.33057369
47PLK11.30693904
48LATS21.29104991
49NEK91.28749308
50PAK31.28530734
51FGFR21.26032890
52ERBB41.20844880
53MET1.20213052
54NEK61.18931447
55PTK61.11698830
56PRKD31.11304200
57CDK81.10454572
58EIF2AK31.08456683
59PASK1.07530987
60GRK11.06424484
61CAMK1D1.06060736
62RIPK11.03489673
63DYRK21.03371762
64PTK2B1.02254336
65FGFR11.02125677
66CHEK20.99960337
67CDK190.93673920
68BRSK10.93202454
69PDGFRB0.91355428
70IRAK10.90488403
71NEK20.86942958
72MAP3K40.86913379
73STK160.86348061
74ERBB20.85390951
75PLK30.83694510
76PAK40.82801407
77ADRBK10.82704491
78DMPK0.79770776
79ATR0.79536675
80MAP4K20.78269730
81STK390.77995001
82EPHA40.77691477
83AURKB0.76438132
84MAP3K100.76335259
85EIF2AK10.75666469
86NME10.74280774
87PRKCE0.73461950
88ROCK20.72845787
89MOS0.69913368
90TNIK0.68785836
91GSK3A0.65754125
92ATM0.65703242
93EPHA20.64697046
94INSR0.63944212
95OXSR10.63630045
96RPS6KA40.63241419
97CSNK1G20.62798606
98MAP2K10.62596430
99MAPK70.62510650
100IRAK20.61915337
101CDK30.61866526
102YES10.60614163
103NLK0.60557763
104STK240.59302299
105FLT30.56476130
106CSNK1G30.56390254
107CHUK0.56264244
108IGF1R0.55863429
109CAMK1G0.55693031
110CCNB10.55183334
111PTK20.53730468
112WNK40.53600024
113BRD40.52869872
114CSNK1G10.52562909
115BMX0.52330428
116CHEK10.52153283
117SGK20.49332039
118CSNK1E0.49116531
119WNK10.48361632
120BCR0.48063810
121PBK0.46815255
122ALK0.45779622
123CDK70.42615562
124RPS6KB10.41390817
125MAPK130.39087617
126CDK10.38739465
127SRC0.38679056
128LIMK10.36669142
129MAPKAPK50.36535963
130PRKDC0.36484800
131MUSK0.36189589
132CAMKK20.36031960
133MTOR0.35613744
134FGFR30.35297170
135EPHB10.35089773
136ILK0.34916748
137MST1R0.34751884
138PRKCG0.34224450
139CLK10.33457668
140CSNK2A10.31514752
141PRKG20.30348833
142AKT10.29661039
143MELK0.29465857
144MAPK150.28926564
145BRSK20.28832128
146CDK20.28476737
147STK40.27759544
148KSR10.26946515
149LRRK20.26613915
150CSNK1A1L0.26354823
151SGK4940.25009909
152SGK2230.25009909
153RPS6KA20.23016442
154CDK60.22139563
155CDK90.21073272
156INSRR0.20613087
157MAPK90.19897246

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.14152796
2Mismatch repair_Homo sapiens_hsa034302.83556957
3Focal adhesion_Homo sapiens_hsa045102.80875733
4Basal cell carcinoma_Homo sapiens_hsa052172.33738077
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.28382686
6Phototransduction_Homo sapiens_hsa047442.25847310
7DNA replication_Homo sapiens_hsa030302.25709790
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22149469
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22091834
10Hippo signaling pathway_Homo sapiens_hsa043902.21207296
11Proteasome_Homo sapiens_hsa030502.18255171
12Adherens junction_Homo sapiens_hsa045202.14336617
13TGF-beta signaling pathway_Homo sapiens_hsa043502.12825929
14Homologous recombination_Homo sapiens_hsa034402.10349535
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06826570
16Cysteine and methionine metabolism_Homo sapiens_hsa002702.04806130
17Protein digestion and absorption_Homo sapiens_hsa049742.02823512
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.02498925
19Hedgehog signaling pathway_Homo sapiens_hsa043402.01962241
20Protein export_Homo sapiens_hsa030601.98866163
21Malaria_Homo sapiens_hsa051441.95794889
22RNA polymerase_Homo sapiens_hsa030201.95499383
23Proteoglycans in cancer_Homo sapiens_hsa052051.92452560
24Selenocompound metabolism_Homo sapiens_hsa004501.91837127
25RNA transport_Homo sapiens_hsa030131.90339569
26Small cell lung cancer_Homo sapiens_hsa052221.90204829
27Basal transcription factors_Homo sapiens_hsa030221.89361079
28Propanoate metabolism_Homo sapiens_hsa006401.87252245
29Vitamin B6 metabolism_Homo sapiens_hsa007501.86924855
30Dilated cardiomyopathy_Homo sapiens_hsa054141.84670016
31Steroid biosynthesis_Homo sapiens_hsa001001.84290454
32MicroRNAs in cancer_Homo sapiens_hsa052061.81640051
33Ribosome_Homo sapiens_hsa030101.81379014
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.79910802
35Fanconi anemia pathway_Homo sapiens_hsa034601.78631464
36Melanoma_Homo sapiens_hsa052181.76816284
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76277695
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74917007
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74476290
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.73472413
41Spliceosome_Homo sapiens_hsa030401.73005242
42One carbon pool by folate_Homo sapiens_hsa006701.72532344
43Wnt signaling pathway_Homo sapiens_hsa043101.68591486
44Axon guidance_Homo sapiens_hsa043601.63048764
45Nucleotide excision repair_Homo sapiens_hsa034201.56399964
46RNA degradation_Homo sapiens_hsa030181.55357717
47Amoebiasis_Homo sapiens_hsa051461.52554150
48Pyruvate metabolism_Homo sapiens_hsa006201.51908739
49Base excision repair_Homo sapiens_hsa034101.51096516
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50210302
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48346015
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47538818
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40437071
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38358985
55Pathways in cancer_Homo sapiens_hsa052001.37657386
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30940940
57Melanogenesis_Homo sapiens_hsa049161.29264618
58Tight junction_Homo sapiens_hsa045301.27848183
59Biosynthesis of amino acids_Homo sapiens_hsa012301.26356747
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23922257
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23113200
62mRNA surveillance pathway_Homo sapiens_hsa030151.20114870
63Prostate cancer_Homo sapiens_hsa052151.18989353
64Viral myocarditis_Homo sapiens_hsa054161.18714639
65Huntingtons disease_Homo sapiens_hsa050161.18179759
66Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17642376
67Oxidative phosphorylation_Homo sapiens_hsa001901.17065016
68Rap1 signaling pathway_Homo sapiens_hsa040151.16661692
69Vitamin digestion and absorption_Homo sapiens_hsa049771.15697633
70Parkinsons disease_Homo sapiens_hsa050121.14050923
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12381796
72Bladder cancer_Homo sapiens_hsa052191.11327424
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09264374
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07726864
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.07644334
76Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04565114
77Platelet activation_Homo sapiens_hsa046111.03766257
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95866779
79p53 signaling pathway_Homo sapiens_hsa041150.95799096
80Chronic myeloid leukemia_Homo sapiens_hsa052200.95791789
81Pyrimidine metabolism_Homo sapiens_hsa002400.95291321
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93251666
83Carbon metabolism_Homo sapiens_hsa012000.92025934
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91997296
85Ras signaling pathway_Homo sapiens_hsa040140.91684701
86Glutathione metabolism_Homo sapiens_hsa004800.91218927
87Arginine and proline metabolism_Homo sapiens_hsa003300.90741240
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88843318
89Purine metabolism_Homo sapiens_hsa002300.88007123
90HTLV-I infection_Homo sapiens_hsa051660.87786277
91TNF signaling pathway_Homo sapiens_hsa046680.85369882
92Folate biosynthesis_Homo sapiens_hsa007900.84800003
93Gap junction_Homo sapiens_hsa045400.79840700
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79457802
95Glioma_Homo sapiens_hsa052140.77185612
96Fatty acid elongation_Homo sapiens_hsa000620.76825313
97Cell cycle_Homo sapiens_hsa041100.74181072
98Oocyte meiosis_Homo sapiens_hsa041140.73396532
99Ovarian steroidogenesis_Homo sapiens_hsa049130.73324328
100Colorectal cancer_Homo sapiens_hsa052100.72346411
101Pancreatic cancer_Homo sapiens_hsa052120.70591300
102Lysine degradation_Homo sapiens_hsa003100.70081326
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69961935
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69772659
105Arachidonic acid metabolism_Homo sapiens_hsa005900.69198604
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.68174787
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66417052
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66294536
109Toxoplasmosis_Homo sapiens_hsa051450.66232566
110beta-Alanine metabolism_Homo sapiens_hsa004100.65877165
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65378950
112Alzheimers disease_Homo sapiens_hsa050100.65132397
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63759179
114African trypanosomiasis_Homo sapiens_hsa051430.63026423
115Metabolic pathways_Homo sapiens_hsa011000.62107924
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61274221
117Hepatitis B_Homo sapiens_hsa051610.60678166
118Fatty acid metabolism_Homo sapiens_hsa012120.60573284
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59269488
120Endometrial cancer_Homo sapiens_hsa052130.58809512
121Notch signaling pathway_Homo sapiens_hsa043300.58477475
122Phagosome_Homo sapiens_hsa041450.58260316
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.58187062
124Retinol metabolism_Homo sapiens_hsa008300.56537889
125FoxO signaling pathway_Homo sapiens_hsa040680.54827078
126Tryptophan metabolism_Homo sapiens_hsa003800.54609316
127Butanoate metabolism_Homo sapiens_hsa006500.54374485
128Shigellosis_Homo sapiens_hsa051310.52968439
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52704847
130Viral carcinogenesis_Homo sapiens_hsa052030.51304556
131Alcoholism_Homo sapiens_hsa050340.50580813
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49333020
133Fatty acid degradation_Homo sapiens_hsa000710.48954102
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.47776621
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47102383
136Peroxisome_Homo sapiens_hsa041460.46849585
137Cardiac muscle contraction_Homo sapiens_hsa042600.46228494
138Salmonella infection_Homo sapiens_hsa051320.45545329
139MAPK signaling pathway_Homo sapiens_hsa040100.45194324
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45024168
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.44732741
142Histidine metabolism_Homo sapiens_hsa003400.43859863
143Renin secretion_Homo sapiens_hsa049240.42032710
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.42006340
145Thyroid cancer_Homo sapiens_hsa052160.42005132
146Long-term depression_Homo sapiens_hsa047300.41848917
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41609473
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41597953
149cAMP signaling pathway_Homo sapiens_hsa040240.41346377
150Non-homologous end-joining_Homo sapiens_hsa034500.40101106
151Oxytocin signaling pathway_Homo sapiens_hsa049210.38691087
152Estrogen signaling pathway_Homo sapiens_hsa049150.37634413
153Cocaine addiction_Homo sapiens_hsa050300.37349829
154ErbB signaling pathway_Homo sapiens_hsa040120.37265403
155Thyroid hormone synthesis_Homo sapiens_hsa049180.37124892
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37006608
157Fat digestion and absorption_Homo sapiens_hsa049750.36857892
158Systemic lupus erythematosus_Homo sapiens_hsa053220.34095650
159HIF-1 signaling pathway_Homo sapiens_hsa040660.34058671
160Rheumatoid arthritis_Homo sapiens_hsa053230.33266111
161Sphingolipid metabolism_Homo sapiens_hsa006000.32882165
162Serotonergic synapse_Homo sapiens_hsa047260.30768650
163Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30387603
164Apoptosis_Homo sapiens_hsa042100.29850158
165Nicotine addiction_Homo sapiens_hsa050330.29751956
166Sulfur metabolism_Homo sapiens_hsa009200.29626308
167Renal cell carcinoma_Homo sapiens_hsa052110.29482543
168Circadian entrainment_Homo sapiens_hsa047130.28578997
169Neurotrophin signaling pathway_Homo sapiens_hsa047220.28455053
170Circadian rhythm_Homo sapiens_hsa047100.28421669
171Taste transduction_Homo sapiens_hsa047420.27691645
172Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26791405
173GnRH signaling pathway_Homo sapiens_hsa049120.26239212
174Cholinergic synapse_Homo sapiens_hsa047250.25697879

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