GUSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.27840316
2modulation by symbiont of host immune response (GO:0052553)6.27840316
3positive regulation by symbiont of host defense response (GO:0052509)6.27840316
4modulation by symbiont of host defense response (GO:0052031)6.27840316
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.27840316
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.27840316
7regulation of interferon-beta biosynthetic process (GO:0045357)5.32793063
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.18954117
9neutrophil activation involved in immune response (GO:0002283)5.12304261
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.65990793
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.58304176
12macrophage activation involved in immune response (GO:0002281)4.54023134
13response to peptidoglycan (GO:0032494)4.50460380
14glycosphingolipid catabolic process (GO:0046479)4.49496907
15respiratory burst (GO:0045730)4.47467944
16immunoglobulin mediated immune response (GO:0016064)4.36867408
17positive regulation of interferon-alpha production (GO:0032727)4.32065563
18regulation of B cell receptor signaling pathway (GO:0050855)4.26890273
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.13111422
20response to host immune response (GO:0052572)4.13111422
21regulation of interferon-alpha production (GO:0032647)4.07845040
22pinocytosis (GO:0006907)4.07553249
23glycolipid catabolic process (GO:0019377)4.03456515
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.93833191
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93833191
26positive regulation of antigen processing and presentation (GO:0002579)3.92704088
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.87955863
28oligosaccharide catabolic process (GO:0009313)3.82905184
29production of molecular mediator involved in inflammatory response (GO:0002532)3.78599171
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.77632632
31response to host (GO:0075136)3.77632632
32response to host defenses (GO:0052200)3.77632632
33antigen processing and presentation of endogenous antigen (GO:0019883)3.75156513
34myeloid cell activation involved in immune response (GO:0002275)3.72680342
35ceramide catabolic process (GO:0046514)3.68651766
36microglial cell activation (GO:0001774)3.62049665
37amino sugar catabolic process (GO:0046348)3.60999226
38positive regulation of B cell differentiation (GO:0045579)3.59769779
39neutrophil mediated immunity (GO:0002446)3.58065402
40cellular extravasation (GO:0045123)3.56441215
41regulation of antigen processing and presentation (GO:0002577)3.38126761
42B cell mediated immunity (GO:0019724)3.35201206
43neutrophil activation (GO:0042119)3.33830202
44macrophage activation (GO:0042116)3.28676799
45response to muramyl dipeptide (GO:0032495)3.26233584
46granulocyte activation (GO:0036230)3.23841673
47negative regulation of erythrocyte differentiation (GO:0045647)3.23099053
48positive regulation of gamma-delta T cell activation (GO:0046645)3.21576467
49negative regulation of phagocytosis (GO:0050765)3.20957023
50regulation of interleukin-8 biosynthetic process (GO:0045414)3.17456410
51response to thyroid hormone (GO:0097066)3.16788902
52positive regulation of interferon-beta production (GO:0032728)3.07205572
53antigen processing and presentation via MHC class Ib (GO:0002475)3.07076670
54regulation of mast cell activation (GO:0033003)3.05065305
55positive regulation of triglyceride lipase activity (GO:0061365)3.02959244
56positive regulation of lipoprotein lipase activity (GO:0051006)3.02959244
57actin nucleation (GO:0045010)3.02226258
58regulation of mast cell degranulation (GO:0043304)2.99017368
59mannose metabolic process (GO:0006013)2.93612342
60positive regulation of mast cell activation (GO:0033005)2.93065744
61leukocyte mediated cytotoxicity (GO:0001909)2.92571110
62regulation of B cell differentiation (GO:0045577)2.92554448
63sphingolipid catabolic process (GO:0030149)2.91738297
64lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87550153
65superoxide anion generation (GO:0042554)2.86514420
66detection of molecule of bacterial origin (GO:0032490)2.83966610
67response to fungus (GO:0009620)2.81339443
68myeloid leukocyte activation (GO:0002274)2.80722664
69regulation of mast cell activation involved in immune response (GO:0033006)2.80647782
70N-acetylneuraminate metabolic process (GO:0006054)2.80380300
71negative regulation of granulocyte differentiation (GO:0030853)2.79340525
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78916066
73natural killer cell mediated immunity (GO:0002228)2.78629885
74natural killer cell mediated cytotoxicity (GO:0042267)2.78629885
75negative regulation of mast cell activation (GO:0033004)2.78621149
76membrane lipid catabolic process (GO:0046466)2.78608898
77reactive oxygen species biosynthetic process (GO:1903409)2.78001448
78B cell receptor signaling pathway (GO:0050853)2.77988546
79leukotriene metabolic process (GO:0006691)2.77879045
80mast cell activation (GO:0045576)2.77542853
81negative regulation of interleukin-12 production (GO:0032695)2.77003436
82regulation of mononuclear cell migration (GO:0071675)2.76966409
83negative regulation of myeloid cell apoptotic process (GO:0033033)2.76708972
84autophagic vacuole fusion (GO:0000046)2.75237235
85myeloid dendritic cell activation (GO:0001773)2.72292270
86I-kappaB phosphorylation (GO:0007252)2.70734529
87detection of bacterium (GO:0016045)2.70425676
88regulation of superoxide anion generation (GO:0032928)2.68420149
89negative regulation of interleukin-17 production (GO:0032700)2.68354726
90hydrogen peroxide biosynthetic process (GO:0050665)2.67623221
91cellular response to thyroid hormone stimulus (GO:0097067)2.67251391
92response to interferon-beta (GO:0035456)2.65256998
93myeloid leukocyte mediated immunity (GO:0002444)2.64191778
94leukocyte degranulation (GO:0043299)2.63866402
95response to interferon-alpha (GO:0035455)2.63330526
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62422405
97negative regulation of interleukin-6 production (GO:0032715)2.60475732
98detection of other organism (GO:0098543)2.60350929
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59708712
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59658236
101leukocyte migration involved in inflammatory response (GO:0002523)2.57529874
102positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57132812
103apoptotic cell clearance (GO:0043277)2.57108856
104NIK/NF-kappaB signaling (GO:0038061)2.56409520
105positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.55605450
106regulation of leukocyte degranulation (GO:0043300)2.55532920
107positive regulation of chemokine biosynthetic process (GO:0045080)2.53537020
108positive regulation of chemokine secretion (GO:0090197)2.52659090
109leukocyte aggregation (GO:0070486)2.52645146
110dendritic cell differentiation (GO:0097028)2.50442467
111neutrophil chemotaxis (GO:0030593)2.49695415
112mature B cell differentiation involved in immune response (GO:0002313)2.49472699
113defense response to protozoan (GO:0042832)2.49129152
114regulation of gamma-delta T cell activation (GO:0046643)2.48370502
115cellular response to interferon-beta (GO:0035458)2.48369488
116keratan sulfate catabolic process (GO:0042340)2.47473653
117complement activation, alternative pathway (GO:0006957)2.47172035
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46795310
119cellular response to type I interferon (GO:0071357)2.45908165
120type I interferon signaling pathway (GO:0060337)2.45908165
121negative regulation of innate immune response (GO:0045824)2.45653690
122regulation of cholesterol storage (GO:0010885)2.45424596
123myeloid dendritic cell differentiation (GO:0043011)2.45328519
124regulation of B cell apoptotic process (GO:0002902)2.44837241
125negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.39797291
126phosphatidylglycerol biosynthetic process (GO:0006655)2.37313602
127negative regulation of B cell apoptotic process (GO:0002903)2.36786892
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.35491516
129L-phenylalanine metabolic process (GO:0006558)2.35330499
130erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.35330499
131amyloid precursor protein catabolic process (GO:0042987)2.34093827
132lysosome organization (GO:0007040)2.33654501
133lytic vacuole organization (GO:0080171)2.33654501
134regulation of gamma-delta T cell differentiation (GO:0045586)2.33103873
135pentose metabolic process (GO:0019321)2.32983097
136peptide catabolic process (GO:0043171)2.32551343
137pyrimidine nucleoside salvage (GO:0043097)2.31737730
138pyrimidine-containing compound salvage (GO:0008655)2.31737730
139lipopolysaccharide metabolic process (GO:0008653)2.31246613
140negative regulation of nitric oxide biosynthetic process (GO:0045019)2.30214260
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.29950235
142purine deoxyribonucleotide catabolic process (GO:0009155)2.29126409
143fat-soluble vitamin biosynthetic process (GO:0042362)2.25215238
144plasma lipoprotein particle clearance (GO:0034381)2.24905079
145negative regulation of cell killing (GO:0031342)2.22910707
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22910707
147regulation of cholesterol esterification (GO:0010872)2.22314992
148regulation of monocyte differentiation (GO:0045655)2.22239784
149macrophage differentiation (GO:0030225)2.21706853
150detection of external biotic stimulus (GO:0098581)2.20584877
151positive regulation of mast cell degranulation (GO:0043306)2.19172262
152positive regulation of mast cell activation involved in immune response (GO:0033008)2.19172262
153UV protection (GO:0009650)2.18757695
154response to protozoan (GO:0001562)2.18325340
155phospholipid efflux (GO:0033700)2.17954869
156purine nucleotide salvage (GO:0032261)2.16584534
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.15019945
158erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.14261019
159L-phenylalanine catabolic process (GO:0006559)2.14261019
160nucleotide salvage (GO:0043173)2.14072706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.09875286
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.75681918
3E2F7_22180533_ChIP-Seq_HELA_Human4.31792272
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.22493650
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.60334934
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.54647640
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48970853
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.25405830
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.11290837
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.10850986
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89588303
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72202471
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68201372
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67793924
15SPI1_23547873_ChIP-Seq_NB4_Human2.47550402
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46480621
17VDR_21846776_ChIP-Seq_THP-1_Human2.35819093
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32777712
19SCL_19346495_ChIP-Seq_HPC-7_Human2.31349804
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25184505
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22824296
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17851452
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03573686
24VDR_24763502_ChIP-Seq_THP-1_Human2.03490028
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02635113
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00695397
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.98237718
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95247803
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89835975
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87021639
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.86540480
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84027939
33SPI1_23127762_ChIP-Seq_K562_Human1.82068887
34MYC_22102868_ChIP-Seq_BL_Human1.79665401
35MYB_26560356_Chip-Seq_TH2_Human1.72670631
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72159216
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.71225575
38MAF_26560356_Chip-Seq_TH1_Human1.68755573
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65724264
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64027226
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62227121
42PU_27001747_Chip-Seq_BMDM_Mouse1.61923022
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60287638
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.60129351
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59398190
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57934070
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.54447630
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.53054916
49BCL6_27268052_Chip-Seq_Bcells_Human1.52454357
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52262195
51TFEB_21752829_ChIP-Seq_HELA_Human1.50941037
52MYB_26560356_Chip-Seq_TH1_Human1.45889043
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45841744
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44485893
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41185370
56BCOR_27268052_Chip-Seq_Bcells_Human1.38851418
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37821620
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37431793
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37184556
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37154291
61UTX_26944678_Chip-Seq_JUKART_Human1.36278315
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34268319
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33243737
64NCOR1_26117541_ChIP-Seq_K562_Human1.32415462
65GATA1_22025678_ChIP-Seq_K562_Human1.32094929
66ZNF263_19887448_ChIP-Seq_K562_Human1.31816206
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31022611
68P68_20966046_ChIP-Seq_HELA_Human1.30221815
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30080443
70TCF7_22412390_ChIP-Seq_EML_Mouse1.25971173
71RACK7_27058665_Chip-Seq_MCF-7_Human1.25696169
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23154900
73RUNX_20019798_ChIP-Seq_JUKART_Human1.22103746
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20960799
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19225259
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18018587
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17716903
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17311205
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.17209738
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16497558
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14472731
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13929060
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13580069
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13446436
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13239429
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13124400
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12621164
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.10132513
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08676122
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08358332
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06604272
92* SRF_21415370_ChIP-Seq_HL-1_Mouse1.05752491
93VDR_24787735_ChIP-Seq_THP-1_Human1.05554034
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04798158
95KDM2B_26808549_Chip-Seq_DND41_Human1.04361468
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04236972
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04054585
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03573478
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.03539964
100GATA1_19941826_ChIP-Seq_K562_Human1.03389936
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02275619
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01134898
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00899497
104GATA3_27048872_Chip-Seq_THYMUS_Human1.00603321
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00569909
106E2F1_20622854_ChIP-Seq_HELA_Human1.00137871
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99913350
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98984244
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98271235
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98074855
111GATA3_26560356_Chip-Seq_TH2_Human0.94862865
112MAF_26560356_Chip-Seq_TH2_Human0.94593935
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94045769
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92342319
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92040328
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.91192458
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88948412
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88480532
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88164570
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.87157905
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85265610
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81534475
123E2F1_21310950_ChIP-Seq_MCF-7_Human0.80395828
124* MYC_18555785_ChIP-Seq_MESCs_Mouse0.76759355
125VDR_23849224_ChIP-Seq_CD4+_Human0.76698102
126LXR_22292898_ChIP-Seq_THP-1_Human0.76152261
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75489255
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75441882
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74915062
130ELK1_19687146_ChIP-ChIP_HELA_Human0.73771093
131* SPI1_20517297_ChIP-Seq_HL60_Human0.73707395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005058_abnormal_lysosome_morphology3.89173230
2MP0001835_abnormal_antigen_presentation3.80217758
3MP0002139_abnormal_hepatobiliary_system3.59536165
4MP0003436_decreased_susceptibility_to3.48968800
5MP0003303_peritoneal_inflammation3.17724272
6MP0003172_abnormal_lysosome_physiology3.12938625
7MP0002419_abnormal_innate_immunity2.95389648
8MP0003806_abnormal_nucleotide_metabolis2.89719004
9MP0006082_CNS_inflammation2.65606527
10MP0005464_abnormal_platelet_physiology2.56804233
11MP0000569_abnormal_digit_pigmentation2.54979624
12MP0005000_abnormal_immune_tolerance2.54686592
13MP0009785_altered_susceptibility_to2.49499650
14MP0002148_abnormal_hypersensitivity_rea2.43421566
15MP0005025_abnormal_response_to2.42703605
16MP0002452_abnormal_antigen_presenting2.38321924
17MP0003191_abnormal_cellular_cholesterol2.27655158
18MP0009840_abnormal_foam_cell2.21100261
19MP0005387_immune_system_phenotype2.20946051
20MP0001790_abnormal_immune_system2.20946051
21MP0000685_abnormal_immune_system2.17776455
22MP0001800_abnormal_humoral_immune2.14766111
23MP0005365_abnormal_bile_salt2.06740629
24MP0002723_abnormal_immune_serum2.05735727
25MP0001533_abnormal_skeleton_physiology2.02213957
26MP0003300_gastrointestinal_ulcer2.02118906
27MP0001819_abnormal_immune_cell2.00753366
28MP0002420_abnormal_adaptive_immunity2.00258297
29MP0003724_increased_susceptibility_to1.91672750
30MP0005174_abnormal_tail_pigmentation1.91417964
31MP0005671_abnormal_response_to1.90158151
32MP0005451_abnormal_body_composition1.87039192
33MP0002405_respiratory_system_inflammati1.84673325
34MP0002396_abnormal_hematopoietic_system1.80153257
35MP0001845_abnormal_inflammatory_respons1.69576459
36MP0005360_urolithiasis1.69411197
37MP0000465_gastrointestinal_hemorrhage1.60825849
38MP0008438_abnormal_cutaneous_collagen1.59540030
39MP0010307_abnormal_tumor_latency1.59412589
40MP0000716_abnormal_immune_system1.56036199
41MP0002398_abnormal_bone_marrow1.54883479
42MP0000343_altered_response_to1.54214127
43MP0008469_abnormal_protein_level1.53237478
44MP0000689_abnormal_spleen_morphology1.52099628
45MP0009333_abnormal_splenocyte_physiolog1.51949574
46MP0002166_altered_tumor_susceptibility1.51944733
47MP0005257_abnormal_intraocular_pressure1.48847611
48MP0008875_abnormal_xenobiotic_pharmacok1.48499513
49MP0003448_altered_tumor_morphology1.47059174
50MP0000015_abnormal_ear_pigmentation1.46556635
51MP0010155_abnormal_intestine_physiology1.44890038
52MP0001853_heart_inflammation1.43269120
53MP0001545_abnormal_hematopoietic_system1.41005405
54MP0005397_hematopoietic_system_phenotyp1.41005405
55MP0003566_abnormal_cell_adhesion1.40480952
56MP0003195_calcinosis1.40422060
57MP0009278_abnormal_bone_marrow1.39304150
58MP0000858_altered_metastatic_potential1.39145055
59MP0004947_skin_inflammation1.39107294
60MP0003183_abnormal_peptide_metabolism1.39021947
61MP0002429_abnormal_blood_cell1.37806352
62MP0002722_abnormal_immune_system1.37075249
63MP0000490_abnormal_crypts_of1.36687768
64MP0004510_myositis1.30339507
65MP0002998_abnormal_bone_remodeling1.28906441
66MP0005075_abnormal_melanosome_morpholog1.27334951
67MP0002138_abnormal_hepatobiliary_system1.26310872
68MP0005310_abnormal_salivary_gland1.26195582
69MP0001764_abnormal_homeostasis1.22921161
70MP0000604_amyloidosis1.22513138
71MP0009764_decreased_sensitivity_to1.18432969
72MP0002933_joint_inflammation1.15598771
73MP0003075_altered_response_to1.15218930
74MP0002006_tumorigenesis1.13242500
75MP0000371_diluted_coat_color1.12715465
76* MP0004808_abnormal_hematopoietic_stem1.12195409
77MP0001873_stomach_inflammation1.09523439
78MP0001958_emphysema1.06316082
79MP0008260_abnormal_autophagy1.03410990
80MP0003690_abnormal_glial_cell1.03121685
81* MP0005319_abnormal_enzyme/_coenzyme1.03008438
82MP0005083_abnormal_biliary_tract1.02019861
83MP0001851_eye_inflammation1.00592612
84MP0003828_pulmonary_edema0.98979311
85MP0003656_abnormal_erythrocyte_physiolo0.97361694
86* MP0005390_skeleton_phenotype0.96764126
87MP0006054_spinal_hemorrhage0.95244362
88MP0003186_abnormal_redox_activity0.94207779
89MP0003705_abnormal_hypodermis_morpholog0.92303204
90MP0002132_abnormal_respiratory_system0.91999487
91MP0005584_abnormal_enzyme/coenzyme_acti0.91675736
92MP0010352_gastrointestinal_tract_polyps0.90569752
93MP0006036_abnormal_mitochondrial_physio0.89856076
94MP0005085_abnormal_gallbladder_physiolo0.89529203
95MP0005166_decreased_susceptibility_to0.89053930
96MP0010329_abnormal_lipoprotein_level0.88592828
97* MP0009643_abnormal_urine_homeostasis0.87707963
98MP0005023_abnormal_wound_healing0.87463317
99MP0009763_increased_sensitivity_to0.87099359
100MP0003329_amyloid_beta_deposits0.85584836
101MP0002877_abnormal_melanocyte_morpholog0.85199689
102MP0000681_abnormal_thyroid_gland0.83543947
103* MP0002118_abnormal_lipid_homeostasis0.83398131
104* MP0003795_abnormal_bone_structure0.82995709
105MP0000249_abnormal_blood_vessel0.81547185
106MP0003763_abnormal_thymus_physiology0.81368365
107MP0000372_irregular_coat_pigmentation0.78277452
108MP0005165_increased_susceptibility_to0.78102849
109MP0005647_abnormal_sex_gland0.76588072
110MP0000703_abnormal_thymus_morphology0.75614019
111MP0002095_abnormal_skin_pigmentation0.75310644
112MP0005408_hypopigmentation0.74541119
113MP0005164_abnormal_response_to0.72259852
114MP0000598_abnormal_liver_morphology0.71931668
115MP0004782_abnormal_surfactant_physiolog0.71425755
116MP0005332_abnormal_amino_acid0.71297137
117MP0002019_abnormal_tumor_incidence0.68688987
118MP0004019_abnormal_vitamin_homeostasis0.68006735
119MP0005076_abnormal_cell_differentiation0.67279676
120MP0008004_abnormal_stomach_pH0.67035563
121MP0001663_abnormal_digestive_system0.66404842
122MP0009765_abnormal_xenobiotic_induced0.66392618
123MP0003693_abnormal_embryo_hatching0.65809179
124MP0008007_abnormal_cellular_replicative0.65210117
125MP0002136_abnormal_kidney_physiology0.65204648
126MP0000609_abnormal_liver_physiology0.63698943
127MP0000767_abnormal_smooth_muscle0.63530636
128MP0003866_abnormal_defecation0.62906636
129MP0001915_intracranial_hemorrhage0.59712304

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)6.25517787
2Recurrent abscess formation (HP:0002722)6.25292084
3Eczematoid dermatitis (HP:0000976)5.91184422
4Increased cerebral lipofuscin (HP:0011813)5.82037624
5Recurrent bacterial skin infections (HP:0005406)5.48815816
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.23018767
7Recurrent gram-negative bacterial infections (HP:0005420)4.93696124
8Systemic lupus erythematosus (HP:0002725)4.67266804
9Abnormality of macrophages (HP:0004311)4.61248101
10* Dysostosis multiplex (HP:0000943)4.19725505
11Abnormality of glycolipid metabolism (HP:0010969)4.03287950
12Abnormality of liposaccharide metabolism (HP:0010968)4.03287950
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.03287950
14Chronic obstructive pulmonary disease (HP:0006510)3.61340666
15Obstructive lung disease (HP:0006536)3.61340666
16* Urinary glycosaminoglycan excretion (HP:0003541)3.56728551
17* Mucopolysacchariduria (HP:0008155)3.56728551
18Myositis (HP:0100614)3.42520719
19Recurrent skin infections (HP:0001581)3.41353412
20Mediastinal lymphadenopathy (HP:0100721)3.33429040
21* Abnormality of polysaccharide metabolism (HP:0011012)3.33041976
22* Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33041976
23* Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33041976
24Disinhibition (HP:0000734)3.31573280
25Gingivitis (HP:0000230)3.24540613
26Increased serum ferritin (HP:0003281)3.19838803
27Recurrent fungal infections (HP:0002841)3.18968460
28Elevated erythrocyte sedimentation rate (HP:0003565)3.18096119
29Glomerulonephritis (HP:0000099)3.13585842
30Cellulitis (HP:0100658)3.08555343
31Axonal loss (HP:0003447)3.04805065
32Loss of speech (HP:0002371)2.96994583
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.96282701
34Agnosia (HP:0010524)2.93182537
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.92887331
36Petechiae (HP:0000967)2.83355191
37Chronic otitis media (HP:0000389)2.80165624
38Prolonged neonatal jaundice (HP:0006579)2.78035543
39Recurrent viral infections (HP:0004429)2.76439020
40Abnormality of iron homeostasis (HP:0011031)2.76380735
41Periodontitis (HP:0000704)2.75111352
42Osteomyelitis (HP:0002754)2.73583047
43Interstitial pulmonary disease (HP:0006530)2.69705582
44Pustule (HP:0200039)2.65309718
45Thrombocytosis (HP:0001894)2.64727391
46Hepatosplenomegaly (HP:0001433)2.62256363
47Orchitis (HP:0100796)2.60939181
48Spontaneous hematomas (HP:0007420)2.55960614
49Cervical subluxation (HP:0003308)2.52863350
50IgM deficiency (HP:0002850)2.51773420
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.50675159
52Osteolytic defects of the hand bones (HP:0009699)2.50675159
53Cardiomegaly (HP:0001640)2.50459110
54Amyloidosis (HP:0011034)2.47150978
55Basal ganglia calcification (HP:0002135)2.45843694
56Autoimmune thrombocytopenia (HP:0001973)2.44630401
57Abnormality of transition element cation homeostasis (HP:0011030)2.43313411
58Abnormality of complement system (HP:0005339)2.43136029
59Spondylolisthesis (HP:0003302)2.41703302
60Myocardial infarction (HP:0001658)2.41520717
61Urticaria (HP:0001025)2.39066075
62Meningitis (HP:0001287)2.38728808
63Pathologic fracture (HP:0002756)2.34682421
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32856962
65Deep venous thrombosis (HP:0002625)2.32036582
66Albinism (HP:0001022)2.31553773
67Joint hemorrhage (HP:0005261)2.30864343
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.29434199
69Epistaxis (HP:0000421)2.27720828
70Xanthomatosis (HP:0000991)2.24263214
71Vasculitis (HP:0002633)2.24080965
72Prolonged bleeding time (HP:0003010)2.23031393
73Recurrent cutaneous fungal infections (HP:0011370)2.21829141
74Chronic mucocutaneous candidiasis (HP:0002728)2.21829141
75Abnormal platelet function (HP:0011869)2.20836590
76Impaired platelet aggregation (HP:0003540)2.20836590
77Abnormality of the prostate (HP:0008775)2.19531555
78Hypertensive crisis (HP:0100735)2.17454723
79* J-shaped sella turcica (HP:0002680)2.14258027
80Gingival bleeding (HP:0000225)2.13285137
81Nuclear cataract (HP:0100018)2.11943174
82Recurrent pneumonia (HP:0006532)2.10797297
83Hematochezia (HP:0002573)2.10677851
84Vertebral compression fractures (HP:0002953)2.10314296
85Nephritis (HP:0000123)2.08347625
86Agammaglobulinemia (HP:0004432)2.05378834
87Inflammation of the large intestine (HP:0002037)2.04119340
88Pulmonary infiltrates (HP:0002113)2.03817147
89Retrobulbar optic neuritis (HP:0100654)2.03370871
90Optic neuritis (HP:0100653)2.03370871
91Arterial thrombosis (HP:0004420)2.03203812
92Leukocytosis (HP:0001974)2.02622220
93Joint stiffness (HP:0001387)2.02589063
94Hemorrhage of the eye (HP:0011885)2.01889486
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00734141
96Prostate neoplasm (HP:0100787)2.00694011
97Gastrointestinal inflammation (HP:0004386)1.97027247
98Complement deficiency (HP:0004431)1.96665680
99Hyperammonemia (HP:0001987)1.96333997
100Asymmetric septal hypertrophy (HP:0001670)1.96052474
101Bone pain (HP:0002653)1.95438831
102Progressive neurologic deterioration (HP:0002344)1.94612426
103Stomatitis (HP:0010280)1.94579723
104Abnormality of pyrimidine metabolism (HP:0004353)1.94460710
105Poor head control (HP:0002421)1.90975117
106Esophageal neoplasm (HP:0100751)1.90053735
107Neoplasm of head and neck (HP:0012288)1.90053735
108Cholecystitis (HP:0001082)1.89749399
109Abnormal gallbladder physiology (HP:0012438)1.89749399
110Diminished motivation (HP:0000745)1.88619793
111Recurrent lower respiratory tract infections (HP:0002783)1.87418413
112* Thoracic kyphosis (HP:0002942)1.87249705
113Cerebral palsy (HP:0100021)1.87211690
114Dicarboxylic aciduria (HP:0003215)1.85986476
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85986476
116Upper motor neuron abnormality (HP:0002127)1.84429657
117Conjunctival telangiectasia (HP:0000524)1.82544602
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.81570752
119Opisthotonus (HP:0002179)1.81348144
120Seborrheic dermatitis (HP:0001051)1.80663594
121Hemoptysis (HP:0002105)1.80199780
122Skin ulcer (HP:0200042)1.78525153
123Colitis (HP:0002583)1.77745669
124Encephalitis (HP:0002383)1.77240976
125Mucosal telangiectasiae (HP:0100579)1.77199085
126Menorrhagia (HP:0000132)1.75419002
127Apathy (HP:0000741)1.74230561
128Ragged-red muscle fibers (HP:0003200)1.73879932
129Increased IgM level (HP:0003496)1.73416786
130Purpura (HP:0000979)1.73310781
131Neuronal loss in central nervous system (HP:0002529)1.72517516
132Nausea (HP:0002018)1.71210861
133Mesangial abnormality (HP:0001966)1.69062121
134Retinal atrophy (HP:0001105)1.68497141
135Abnormality of lateral ventricle (HP:0030047)1.67431445
136Generalized aminoaciduria (HP:0002909)1.66403680
137* Splenomegaly (HP:0001744)1.65584339
138Abnormal enzyme/coenzyme activity (HP:0012379)1.64616844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.33327154
2KIT3.26976844
3MAP4K13.17529351
4IRAK42.87812449
5ERN12.83505821
6TBK12.52904523
7TYK22.38605772
8TGFBR22.29165747
9MAP3K142.27722728
10BCKDK2.12908635
11PKN22.12166272
12BTK2.08751733
13NME22.03266351
14IRAK32.02073111
15RIPK42.00996342
16CSF1R2.00659693
17ZAP701.97486089
18PIM21.92067680
19TRIB31.90494443
20TAOK31.90432051
21MAP2K31.90271732
22TEC1.83335932
23TAOK21.78069815
24SCYL21.72733394
25SMG11.67629028
26MAPKAPK31.66496918
27PRPF4B1.63980845
28FES1.63082340
29VRK21.62164158
30EPHB11.56838914
31IKBKB1.55585530
32JAK31.51609329
33SYK1.50825797
34STK101.50553557
35NEK91.50366523
36CAMK1D1.41055543
37HCK1.36598918
38IKBKE1.35345157
39JAK11.32218513
40LYN1.32102013
41FLT31.30354332
42CSK1.24705082
43LRRK21.22537251
44RPS6KA41.21996093
45SIK11.18738742
46TAOK11.18426622
47TNK21.18216038
48PAK41.17174739
49TTN1.12864031
50LCK1.09494078
51TXK1.07616936
52TRPM71.07305843
53EEF2K1.01897783
54MAP2K61.00215430
55KDR0.99706221
56ITK0.99600710
57JAK20.97501795
58CAMKK20.97355098
59MATK0.96797921
60EPHA20.96636234
61MAPK110.95251579
62MAP2K20.94325888
63PTK60.90348800
64PIM10.90159711
65CLK10.88369797
66RPS6KB20.88254037
67ARAF0.86925231
68TESK20.83257105
69MAP3K30.82944258
70ABL20.80662015
71DAPK10.77007906
72EIF2AK30.76491729
73CDK60.75333036
74STK40.75324377
75MST1R0.74164669
76BMPR20.73963716
77SIK30.70098811
78GRK60.69839391
79EPHA30.69036201
80MAP3K110.67870611
81CHUK0.67783159
82PIK3CG0.66786122
83BMX0.66288306
84HIPK20.63349954
85TGFBR10.63266768
86ABL10.62856147
87CDC42BPA0.60005410
88NEK20.58418482
89CAMK1G0.57995854
90PDK20.57769311
91PDPK10.56896708
92MAPKAPK20.56767434
93PRKCD0.56581323
94ADRBK20.55875667
95MAP3K80.55563956
96RPS6KA60.55463497
97ICK0.55305372
98EGFR0.54459334
99TESK10.54407978
100IRAK10.54038376
101CDK70.53948808
102PBK0.53472644
103FGFR40.51029469
104IRAK20.50975535
105FGR0.50747417
106MAP3K130.50712994
107MAP3K100.49978360
108MARK30.48890653
109RIPK10.48341964
110RPS6KC10.47126417
111RPS6KL10.47126417
112CAMKK10.47122538
113EIF2AK20.45862090
114RPS6KA20.45538857
115STK30.45503903
116CDK120.45261210
117PRKG20.41941144
118LIMK10.41144683
119YES10.38830629
120CDK40.38439822
121PDK10.38302733
122MOS0.36376669
123SIK20.35726289
124MAPK30.35389245
125MAPK40.34466306
126BRSK20.33955054
127GRK70.31366945
128PASK0.31358370
129MAP3K10.31121086
130IGF1R0.30979923
131PAK10.30075596
132FGFR30.28397246
133MAP3K50.27894812
134ATR0.27716096

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.57641518
2* Glycosaminoglycan degradation_Homo sapiens_hsa005313.42590992
3* Lysosome_Homo sapiens_hsa041423.24679900
4Staphylococcus aureus infection_Homo sapiens_hsa051503.20004546
5Leishmaniasis_Homo sapiens_hsa051403.10529638
6Osteoclast differentiation_Homo sapiens_hsa043802.35356192
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21649024
8Pertussis_Homo sapiens_hsa051332.14418746
9Legionellosis_Homo sapiens_hsa051342.09123752
10Antigen processing and presentation_Homo sapiens_hsa046122.06220235
11Tuberculosis_Homo sapiens_hsa051522.01204179
12Phagosome_Homo sapiens_hsa041451.91118852
13Malaria_Homo sapiens_hsa051441.87201434
14B cell receptor signaling pathway_Homo sapiens_hsa046621.85398224
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.84406510
16Autoimmune thyroid disease_Homo sapiens_hsa053201.82830967
17Measles_Homo sapiens_hsa051621.67548603
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56238695
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55879617
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55713227
21Apoptosis_Homo sapiens_hsa042101.52759316
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.51865710
23DNA replication_Homo sapiens_hsa030301.47824831
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46264008
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44899163
26Shigellosis_Homo sapiens_hsa051311.43224942
27Toxoplasmosis_Homo sapiens_hsa051451.42412663
28Hematopoietic cell lineage_Homo sapiens_hsa046401.38285725
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35963398
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.35050813
31Type I diabetes mellitus_Homo sapiens_hsa049401.34568394
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33840402
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33835994
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33253967
35Influenza A_Homo sapiens_hsa051641.32193430
36Rheumatoid arthritis_Homo sapiens_hsa053231.31482396
37Fructose and mannose metabolism_Homo sapiens_hsa000511.31236192
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30998421
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.29743160
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28689947
41Caffeine metabolism_Homo sapiens_hsa002321.27175750
42Salmonella infection_Homo sapiens_hsa051321.25055399
43* Drug metabolism - other enzymes_Homo sapiens_hsa009831.19735500
44Fatty acid elongation_Homo sapiens_hsa000621.19246308
45Herpes simplex infection_Homo sapiens_hsa051681.19022899
46Complement and coagulation cascades_Homo sapiens_hsa046101.18143979
47Sulfur relay system_Homo sapiens_hsa041221.14052193
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.11041324
49Hepatitis B_Homo sapiens_hsa051611.09209301
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08037278
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07776062
52TNF signaling pathway_Homo sapiens_hsa046681.07671165
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05672388
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01756556
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.99659387
56N-Glycan biosynthesis_Homo sapiens_hsa005100.97008505
57Sulfur metabolism_Homo sapiens_hsa009200.96934742
58Asthma_Homo sapiens_hsa053100.95732524
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95189898
60Chronic myeloid leukemia_Homo sapiens_hsa052200.92683288
61Glutathione metabolism_Homo sapiens_hsa004800.90635467
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88125603
63Fatty acid degradation_Homo sapiens_hsa000710.87931890
64Primary immunodeficiency_Homo sapiens_hsa053400.87897709
65Carbon metabolism_Homo sapiens_hsa012000.87379078
66Renin-angiotensin system_Homo sapiens_hsa046140.87256484
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87224675
68Acute myeloid leukemia_Homo sapiens_hsa052210.86969932
69Chemokine signaling pathway_Homo sapiens_hsa040620.85351533
70Platelet activation_Homo sapiens_hsa046110.84320760
71Pancreatic cancer_Homo sapiens_hsa052120.83639536
72Chemical carcinogenesis_Homo sapiens_hsa052040.82064341
73Peroxisome_Homo sapiens_hsa041460.80211090
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79379315
75Viral myocarditis_Homo sapiens_hsa054160.79229706
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78619747
77Pentose phosphate pathway_Homo sapiens_hsa000300.78287296
78Biosynthesis of amino acids_Homo sapiens_hsa012300.76263328
79Sphingolipid metabolism_Homo sapiens_hsa006000.75744563
80Base excision repair_Homo sapiens_hsa034100.74239216
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73352323
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73299072
83Galactose metabolism_Homo sapiens_hsa000520.73062841
84Hepatitis C_Homo sapiens_hsa051600.72766547
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72361354
86Tyrosine metabolism_Homo sapiens_hsa003500.71438716
87Graft-versus-host disease_Homo sapiens_hsa053320.70933940
88Bladder cancer_Homo sapiens_hsa052190.70276023
89Allograft rejection_Homo sapiens_hsa053300.70192976
90One carbon pool by folate_Homo sapiens_hsa006700.69925838
91Prion diseases_Homo sapiens_hsa050200.69708350
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69437619
93Mismatch repair_Homo sapiens_hsa034300.67009632
94Amoebiasis_Homo sapiens_hsa051460.66004941
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65974418
96Viral carcinogenesis_Homo sapiens_hsa052030.65132532
97Non-homologous end-joining_Homo sapiens_hsa034500.63052897
98Fatty acid metabolism_Homo sapiens_hsa012120.62972801
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62116658
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.61882012
101PPAR signaling pathway_Homo sapiens_hsa033200.61463205
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61301787
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61273579
104Collecting duct acid secretion_Homo sapiens_hsa049660.59065044
105Pyrimidine metabolism_Homo sapiens_hsa002400.58152174
106Vibrio cholerae infection_Homo sapiens_hsa051100.57672894
107Small cell lung cancer_Homo sapiens_hsa052220.57401047
108Epstein-Barr virus infection_Homo sapiens_hsa051690.56407490
109Systemic lupus erythematosus_Homo sapiens_hsa053220.56359875
110Tryptophan metabolism_Homo sapiens_hsa003800.55332177
111Phenylalanine metabolism_Homo sapiens_hsa003600.53811001
112Arginine biosynthesis_Homo sapiens_hsa002200.53618443
113Retinol metabolism_Homo sapiens_hsa008300.52306395
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52164048
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51738698
116* Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51123010
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.48741236
118Homologous recombination_Homo sapiens_hsa034400.48133556
119HIF-1 signaling pathway_Homo sapiens_hsa040660.45857304
120T cell receptor signaling pathway_Homo sapiens_hsa046600.45026718
121* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42773001
122p53 signaling pathway_Homo sapiens_hsa041150.42703207
123Protein export_Homo sapiens_hsa030600.41198607
124Ribosome_Homo sapiens_hsa030100.41000396
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40359498
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38250925
127HTLV-I infection_Homo sapiens_hsa051660.38120530
128Histidine metabolism_Homo sapiens_hsa003400.37973480
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.34929701
130Endocytosis_Homo sapiens_hsa041440.34929412
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34232680
132Arachidonic acid metabolism_Homo sapiens_hsa005900.31785009
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31757637
134Non-small cell lung cancer_Homo sapiens_hsa052230.30951887
135Proteoglycans in cancer_Homo sapiens_hsa052050.28270530
136VEGF signaling pathway_Homo sapiens_hsa043700.27395946
137African trypanosomiasis_Homo sapiens_hsa051430.26462112
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.25665493
139Proteasome_Homo sapiens_hsa030500.25578499

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