ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.74723360
2	response to pheromone (GO:0019236)	4.62938515
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.10296802
4	L-fucose catabolic process (GO:0042355)	3.85308462
5	fucose catabolic process (GO:0019317)	3.85308462
6	L-fucose metabolic process (GO:0042354)	3.85308462
7	epithelial cilium movement (GO:0003351)	3.79141372
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.66392272
9	preassembly of GPI anchor in ER membrane (GO:0016254)	3.59216345
10	DNA deamination (GO:0045006)	3.56636725
11	neural tube formation (GO:0001841)	3.55342173
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53436127
13	NADH dehydrogenase complex assembly (GO:0010257)	3.53436127
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53436127
15	protein complex biogenesis (GO:0070271)	3.52585453
16	regulation of cilium movement (GO:0003352)	3.33397524
17	nonmotile primary cilium assembly (GO:0035058)	3.28445124
18	protein polyglutamylation (GO:0018095)	3.23729148
19	mannosylation (GO:0097502)	3.20920926
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.19245138
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19073240
22	cellular ketone body metabolic process (GO:0046950)	3.16406983
23	nucleobase catabolic process (GO:0046113)	3.16284981
24	indolalkylamine metabolic process (GO:0006586)	3.10580870
25	axoneme assembly (GO:0035082)	3.10527945
26	ubiquinone biosynthetic process (GO:0006744)	3.09549223
27	tryptophan catabolic process (GO:0006569)	3.08157847
28	indole-containing compound catabolic process (GO:0042436)	3.08157847
29	indolalkylamine catabolic process (GO:0046218)	3.08157847
30	centriole replication (GO:0007099)	3.01153297
31	cilium movement (GO:0003341)	2.98535351
32	piRNA metabolic process (GO:0034587)	2.98071307
33	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.95766490
34	DNA double-strand break processing (GO:0000729)	2.94370186
35	intraciliary transport (GO:0042073)	2.93479592
36	ubiquinone metabolic process (GO:0006743)	2.93050413
37	GPI anchor metabolic process (GO:0006505)	2.91956228
38	somite development (GO:0061053)	2.89935771
39	respiratory chain complex IV assembly (GO:0008535)	2.88642513
40	cilium morphogenesis (GO:0060271)	2.87111688
41	ketone body metabolic process (GO:1902224)	2.86578155
42	cilium organization (GO:0044782)	2.86047802
43	kynurenine metabolic process (GO:0070189)	2.82393931
44	cilium assembly (GO:0042384)	2.77861833
45	cytochrome complex assembly (GO:0017004)	2.77839026
46	negative regulation of mast cell activation (GO:0033004)	2.76356803
47	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.76086488
48	protein localization to cilium (GO:0061512)	2.71438308
49	cornea development in camera-type eye (GO:0061303)	2.71312690
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.70832953
51	detection of light stimulus involved in visual perception (GO:0050908)	2.70832953
52	photoreceptor cell maintenance (GO:0045494)	2.69980167
53	regulation of glucokinase activity (GO:0033131)	2.69651331
54	regulation of hexokinase activity (GO:1903299)	2.69651331
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69140955
56	tryptophan metabolic process (GO:0006568)	2.68441348
57	negative regulation of telomere maintenance (GO:0032205)	2.68248079
58	DNA methylation involved in gamete generation (GO:0043046)	2.65546879
59	seminiferous tubule development (GO:0072520)	2.62794804
60	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.62075990
61	inositol phosphate catabolic process (GO:0071545)	2.61360632
62	platelet dense granule organization (GO:0060155)	2.61140655
63	kidney morphogenesis (GO:0060993)	2.56997336
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56681282
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56681282
66	replication fork processing (GO:0031297)	2.55487056
67	presynaptic membrane assembly (GO:0097105)	2.54956131
68	photoreceptor cell development (GO:0042461)	2.52537581
69	sperm motility (GO:0030317)	2.51686565
70	nephron epithelium morphogenesis (GO:0072088)	2.51475534
71	nephron tubule morphogenesis (GO:0072078)	2.51475534
72	cilium or flagellum-dependent cell motility (GO:0001539)	2.48272001
73	regulation of microtubule-based movement (GO:0060632)	2.48104315
74	recombinational repair (GO:0000725)	2.47943029
75	GPI anchor biosynthetic process (GO:0006506)	2.47349672
76	neuron fate determination (GO:0048664)	2.46361495
77	regulation of action potential (GO:0098900)	2.45978433
78	amine catabolic process (GO:0009310)	2.45742028
79	cellular biogenic amine catabolic process (GO:0042402)	2.45742028
80	reciprocal DNA recombination (GO:0035825)	2.45521966
81	reciprocal meiotic recombination (GO:0007131)	2.45521966
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.45451873
83	behavioral response to ethanol (GO:0048149)	2.44818701
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.43966243
85	C-terminal protein lipidation (GO:0006501)	2.43841252
86	regulation of neurotransmitter uptake (GO:0051580)	2.43228307
87	double-strand break repair via homologous recombination (GO:0000724)	2.42961528
88	polyol catabolic process (GO:0046174)	2.42518711
89	quinone biosynthetic process (GO:1901663)	2.41465057
90	postsynaptic membrane organization (GO:0001941)	2.40834399
91	neuronal action potential (GO:0019228)	2.39955931
92	C-terminal protein amino acid modification (GO:0018410)	2.39496946
93	resolution of meiotic recombination intermediates (GO:0000712)	2.39155131
94	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.39064162
95	retinal ganglion cell axon guidance (GO:0031290)	2.37961790
96	gamma-aminobutyric acid transport (GO:0015812)	2.37642681
97	rhodopsin mediated signaling pathway (GO:0016056)	2.36704313
98	regulation of telomere maintenance (GO:0032204)	2.35112357
99	synaptic transmission, cholinergic (GO:0007271)	2.34642983
100	retinal cone cell development (GO:0046549)	2.33701131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.10684990
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.14764453
3	VDR_22108803_ChIP-Seq_LS180_Human	3.08074636
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.00468990
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.76555478
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44403648
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35545305
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30443939
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.28069692
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.24674570
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21188239
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.20836659
13	FUS_26573619_Chip-Seq_HEK293_Human	2.19224143
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16627583
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16160303
16	EWS_26573619_Chip-Seq_HEK293_Human	2.13255052
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11785706
18	IRF1_19129219_ChIP-ChIP_H3396_Human	2.00237981
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.98751580
20	P300_19829295_ChIP-Seq_ESCs_Human	1.92205334
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90439944
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.88750484
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.84990533
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77475839
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72767224
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.72466415
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63276154
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.63276154
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57441168
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.56027195
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.55596380
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.54272968
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53700617
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.52239639
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51458616
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.49621330
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47711493
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43103614
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.41358945
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40929805
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40697322
42	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39647921
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38710062
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.37915555
45	AR_25329375_ChIP-Seq_VCAP_Human	1.37495515
46	STAT3_23295773_ChIP-Seq_U87_Human	1.36627938
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36596139
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36246361
49	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.34753640
50	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33736494
51	TCF4_23295773_ChIP-Seq_U87_Human	1.32147233
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30959603
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30959603
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29471337
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29471337
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26391922
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26389264
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25986014
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25587810
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.25353369
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24813517
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24360521
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22931964
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22279511
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22279511
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21041457
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20937854
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.20157987
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.18594499
70	NCOR_22424771_ChIP-Seq_293T_Human	1.17593723
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16307210
72	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14985219
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12051216
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11756085
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11309942
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11065689
77	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09604053
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07940839
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07134900
80	AR_20517297_ChIP-Seq_VCAP_Human	1.06691727
81	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06510132
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.06405219
83	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06090577
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05732948
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05548112
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05305331
87	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.04265546
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03128147
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01931998
90	ERA_21632823_ChIP-Seq_H3396_Human	1.00929579
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00056961
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98711703
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98693794
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98173125
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.97967036
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97862396
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96951307
98	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.95647005
99	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95302301
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95253801

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.98270629
2	MP0006292_abnormal_olfactory_placode	2.95340227
3	MP0003787_abnormal_imprinting	2.90199102
4	MP0006072_abnormal_retinal_apoptosis	2.43282678
5	MP0005551_abnormal_eye_electrophysiolog	2.34234525
6	MP0003136_yellow_coat_color	2.19039847
7	MP0000569_abnormal_digit_pigmentation	2.12881163
8	MP0002102_abnormal_ear_morphology	2.08063799
9	MP0002638_abnormal_pupillary_reflex	2.06824117
10	MP0002653_abnormal_ependyma_morphology	2.05241668
11	MP0003880_abnormal_central_pattern	2.01236861
12	MP0004147_increased_porphyrin_level	1.99923227
13	MP0001968_abnormal_touch/_nociception	1.99175227
14	MP0005646_abnormal_pituitary_gland	1.99023719
15	MP0005645_abnormal_hypothalamus_physiol	1.91187597
16	MP0000372_irregular_coat_pigmentation	1.79184217
17	MP0005253_abnormal_eye_physiology	1.78947330
18	MP0000631_abnormal_neuroendocrine_gland	1.73430792
19	MP0002837_dystrophic_cardiac_calcinosis	1.70914966
20	MP0004133_heterotaxia	1.70610868
21	MP0008789_abnormal_olfactory_epithelium	1.67176184
22	MP0006276_abnormal_autonomic_nervous	1.66250195
23	MP0001986_abnormal_taste_sensitivity	1.64337542
24	MP0008872_abnormal_physiological_respon	1.64252470
25	MP0004142_abnormal_muscle_tone	1.63756048
26	MP0003121_genomic_imprinting	1.63537369
27	MP0003195_calcinosis	1.61763646
28	MP0002736_abnormal_nociception_after	1.58307506
29	MP0003011_delayed_dark_adaptation	1.56532858
30	MP0005174_abnormal_tail_pigmentation	1.53509051
31	MP0001529_abnormal_vocalization	1.51744549
32	MP0009046_muscle_twitch	1.50609213
33	MP0005499_abnormal_olfactory_system	1.50466432
34	MP0005394_taste/olfaction_phenotype	1.50466432
35	MP0009745_abnormal_behavioral_response	1.49689746
36	MP0002272_abnormal_nervous_system	1.46570175
37	MP0003122_maternal_imprinting	1.46085080
38	MP0001984_abnormal_olfaction	1.44986704
39	MP0005084_abnormal_gallbladder_morpholo	1.44553430
40	MP0002938_white_spotting	1.44321738
41	MP0002735_abnormal_chemical_nociception	1.44297902
42	MP0000427_abnormal_hair_cycle	1.41353689
43	MP0008058_abnormal_DNA_repair	1.40351269
44	MP0001485_abnormal_pinna_reflex	1.38384441
45	MP0002557_abnormal_social/conspecific_i	1.35435386
46	MP0003646_muscle_fatigue	1.35259401
47	MP0002163_abnormal_gland_morphology	1.35033971
48	MP0002160_abnormal_reproductive_system	1.34887972
49	MP0008875_abnormal_xenobiotic_pharmacok	1.31826384
50	MP0008995_early_reproductive_senescence	1.30456607
51	MP0002822_catalepsy	1.30024150
52	MP0000778_abnormal_nervous_system	1.29566822
53	MP0004885_abnormal_endolymph	1.28391050
54	MP0005410_abnormal_fertilization	1.22954580
55	MP0005389_reproductive_system_phenotype	1.21481264
56	MP0002876_abnormal_thyroid_physiology	1.20606674
57	MP0002572_abnormal_emotion/affect_behav	1.20505642
58	MP0002733_abnormal_thermal_nociception	1.19351565
59	MP0005075_abnormal_melanosome_morpholog	1.19147127
60	MP0002095_abnormal_skin_pigmentation	1.16103986
61	MP0001970_abnormal_pain_threshold	1.15549807
62	MP0001486_abnormal_startle_reflex	1.15485111
63	MP0005379_endocrine/exocrine_gland_phen	1.14940095
64	MP0004043_abnormal_pH_regulation	1.13118761
65	MP0005195_abnormal_posterior_eye	1.10752788
66	MP0002234_abnormal_pharynx_morphology	1.10106473
67	MP0005386_behavior/neurological_phenoty	1.08808331
68	MP0004924_abnormal_behavior	1.08808331
69	MP0001501_abnormal_sleep_pattern	1.05962630
70	MP0001293_anophthalmia	1.05570106
71	MP0002928_abnormal_bile_duct	1.04934447
72	MP0003698_abnormal_male_reproductive	1.04585868
73	MP0002752_abnormal_somatic_nervous	1.02189149
74	MP0001905_abnormal_dopamine_level	1.01427399
75	MP0003635_abnormal_synaptic_transmissio	1.00345905
76	MP0010386_abnormal_urinary_bladder	0.99954250
77	MP0005377_hearing/vestibular/ear_phenot	0.99663737
78	MP0003878_abnormal_ear_physiology	0.99663737
79	MP0001929_abnormal_gametogenesis	0.99011603
80	MP0002184_abnormal_innervation	0.98725799
81	MP0001919_abnormal_reproductive_system	0.98578940
82	MP0002067_abnormal_sensory_capabilities	0.98350572
83	MP0003718_maternal_effect	0.96420380
84	MP0004742_abnormal_vestibular_system	0.95931362
85	MP0002751_abnormal_autonomic_nervous	0.95740469
86	MP0002064_seizures	0.95575263
87	MP0002063_abnormal_learning/memory/cond	0.93600693
88	MP0002734_abnormal_mechanical_nocicepti	0.92143172
89	MP0003890_abnormal_embryonic-extraembry	0.89827140
90	MP0004145_abnormal_muscle_electrophysio	0.88369279
91	MP0000015_abnormal_ear_pigmentation	0.88060808
92	MP0005391_vision/eye_phenotype	0.87496625
93	MP0000026_abnormal_inner_ear	0.87491274
94	MP0002210_abnormal_sex_determination	0.85138278
95	MP0001324_abnormal_eye_pigmentation	0.84088945
96	MP0000955_abnormal_spinal_cord	0.84058639
97	MP0000653_abnormal_sex_gland	0.81210647
98	MP0000049_abnormal_middle_ear	0.80464903
99	MP0001764_abnormal_homeostasis	0.80401634
100	MP0002229_neurodegeneration	0.80394304

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.06745724
2	Pancreatic fibrosis (HP:0100732)	3.93379808
3	Nephronophthisis (HP:0000090)	3.82638771
4	Abnormality of midbrain morphology (HP:0002418)	3.77178310
5	Molar tooth sign on MRI (HP:0002419)	3.77178310
6	True hermaphroditism (HP:0010459)	3.66821699
7	Medial flaring of the eyebrow (HP:0010747)	3.61018708
8	Congenital stationary night blindness (HP:0007642)	3.34001896
9	Type II lissencephaly (HP:0007260)	3.32187490
10	Abnormality of the renal medulla (HP:0100957)	3.20639675
11	Abnormality of the renal cortex (HP:0011035)	3.15095985
12	Gait imbalance (HP:0002141)	3.04396719
13	Congenital primary aphakia (HP:0007707)	2.95043276
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.93382954
15	Chronic hepatic failure (HP:0100626)	2.79993240
16	Nephrogenic diabetes insipidus (HP:0009806)	2.75478113
17	Attenuation of retinal blood vessels (HP:0007843)	2.68279639
18	Renal cortical cysts (HP:0000803)	2.65714936
19	Polydipsia (HP:0001959)	2.62362622
20	Abnormal drinking behavior (HP:0030082)	2.62362622
21	Cystic liver disease (HP:0006706)	2.57352268
22	Cerebellar dysplasia (HP:0007033)	2.53550030
23	Hyperventilation (HP:0002883)	2.47709346
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.43998281
25	Abolished electroretinogram (ERG) (HP:0000550)	2.43404527
26	Mitochondrial inheritance (HP:0001427)	2.40642923
27	Pendular nystagmus (HP:0012043)	2.36525732
28	Lissencephaly (HP:0001339)	2.36084363
29	Tubular atrophy (HP:0000092)	2.33852185
30	Genital tract atresia (HP:0001827)	2.33712246
31	3-Methylglutaconic aciduria (HP:0003535)	2.31645392
32	Acute necrotizing encephalopathy (HP:0006965)	2.30883615
33	Poor coordination (HP:0002370)	2.29588832
34	Vaginal atresia (HP:0000148)	2.28080778
35	Sclerocornea (HP:0000647)	2.27434621
36	Increased CSF lactate (HP:0002490)	2.20306996
37	Colon cancer (HP:0003003)	2.17716747
38	Optic nerve hypoplasia (HP:0000609)	2.17057151
39	Acute encephalopathy (HP:0006846)	2.16539131
40	Abnormal biliary tract physiology (HP:0012439)	2.13969662
41	Bile duct proliferation (HP:0001408)	2.13969662
42	Methylmalonic acidemia (HP:0002912)	2.13961082
43	Congenital hepatic fibrosis (HP:0002612)	2.11956407
44	Hepatocellular necrosis (HP:0001404)	2.11613849
45	Large for gestational age (HP:0001520)	2.09698288
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09671576
47	Absent/shortened dynein arms (HP:0200106)	2.09671576
48	Inability to walk (HP:0002540)	2.09053278
49	Hyperglycinemia (HP:0002154)	2.08245336
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06382350
51	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05259077
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.04626839
53	Pachygyria (HP:0001302)	2.04623085
54	Rib fusion (HP:0000902)	2.03422294
55	Broad-based gait (HP:0002136)	2.03209402
56	Progressive macrocephaly (HP:0004481)	2.02337928
57	Lipid accumulation in hepatocytes (HP:0006561)	2.01034569
58	Hepatic necrosis (HP:0002605)	2.00575369
59	Severe visual impairment (HP:0001141)	2.00483036
60	Male pseudohermaphroditism (HP:0000037)	2.00428505
61	Postaxial foot polydactyly (HP:0001830)	1.98514869
62	Decreased central vision (HP:0007663)	1.97849365
63	Postaxial hand polydactyly (HP:0001162)	1.97214411
64	Hypothermia (HP:0002045)	1.97209105
65	Polyuria (HP:0000103)	1.96351344
66	Anencephaly (HP:0002323)	1.95628020
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95587110
68	Abnormality of the labia minora (HP:0012880)	1.95102031
69	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94923801
70	Abnormal respiratory epithelium morphology (HP:0012253)	1.94923801
71	Retinal dysplasia (HP:0007973)	1.94732578
72	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94532525
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94161860
74	Ketosis (HP:0001946)	1.92901398
75	Optic disc pallor (HP:0000543)	1.92201335
76	Methylmalonic aciduria (HP:0012120)	1.90192723
77	Intestinal atresia (HP:0011100)	1.89371063
78	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85627379
79	Abnormality of the pons (HP:0007361)	1.84683569
80	Abnormality of the renal collecting system (HP:0004742)	1.84150054
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.83496965
82	Asplenia (HP:0001746)	1.80028468
83	Hyperglycinuria (HP:0003108)	1.79023651
84	Tubulointerstitial nephritis (HP:0001970)	1.77848853
85	Hypoplasia of the pons (HP:0012110)	1.77526041
86	Abnormality of the ileum (HP:0001549)	1.77516580
87	Progressive inability to walk (HP:0002505)	1.76226738
88	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76045180
89	Abnormality of alanine metabolism (HP:0010916)	1.76045180
90	Hyperalaninemia (HP:0003348)	1.76045180
91	Progressive cerebellar ataxia (HP:0002073)	1.75963965
92	Protruding tongue (HP:0010808)	1.75556625
93	Thyroiditis (HP:0100646)	1.75394894
94	Tachypnea (HP:0002789)	1.75294986
95	Aganglionic megacolon (HP:0002251)	1.74800330
96	Meckel diverticulum (HP:0002245)	1.72992395
97	Astigmatism (HP:0000483)	1.71674556
98	Specific learning disability (HP:0001328)	1.70863098
99	Gaze-evoked nystagmus (HP:0000640)	1.70618069
100	Hemiparesis (HP:0001269)	1.68107037

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.48306547
2	BMPR1B	3.12620551
3	MAP4K2	2.97995006
4	ZAK	2.84570579
5	ADRBK2	2.61704420
6	CASK	2.60267835
7	WNK3	2.35719764
8	NUAK1	2.34138396
9	PINK1	2.33688862
10	MAPK13	2.31811897
11	GRK1	2.29366022
12	TAOK3	2.28640805
13	BCKDK	2.06067777
14	MAP3K4	2.01090661
15	ACVR1B	1.97307388
16	WNK4	1.95806099
17	INSRR	1.75120318
18	TNIK	1.70742903
19	TLK1	1.69297181
20	TXK	1.61015607
21	DYRK2	1.50681845
22	MAP2K7	1.49098273
23	AKT3	1.38225384
24	TRIM28	1.29208198
25	VRK1	1.26326112
26	MARK1	1.21070567
27	MKNK2	1.19559887
28	PAK3	1.19406567
29	EPHA4	1.14440839
30	DAPK2	1.11676056
31	MAPK15	1.07256978
32	CSNK1G2	1.00814303
33	NEK2	0.98945407
34	OXSR1	0.97539837
35	STK39	0.94378790
36	CSNK1G3	0.94210896
37	PLK4	0.94043524
38	ADRBK1	0.89082661
39	CSNK1G1	0.88791512
40	VRK2	0.87651012
41	CAMKK2	0.87013603
42	ERBB3	0.82896172
43	PRKCE	0.81634248
44	MKNK1	0.81544661
45	PLK2	0.79645689
46	PRKCG	0.79177795
47	PRKCQ	0.76908573
48	BCR	0.76779383
49	CSNK1A1L	0.76156902
50	KIT	0.74866727
51	FGFR2	0.72999492
52	EIF2AK3	0.72285399
53	TGFBR1	0.70519764
54	TIE1	0.69234041
55	NTRK2	0.68329587
56	STK38L	0.67445676
57	RPS6KA5	0.67330548
58	TEC	0.66231806
59	DYRK3	0.66034082
60	PRKD3	0.64650420
61	PHKG2	0.64313538
62	PHKG1	0.64313538
63	SGK2	0.64278815
64	NEK1	0.63749087
65	CAMK1	0.63567861
66	NTRK3	0.63084464
67	NME1	0.62205659
68	SGK494	0.61653489
69	SGK223	0.61653489
70	TNK2	0.58351607
71	CSNK1A1	0.58323301
72	BRSK2	0.57052104
73	MARK3	0.56857383
74	ATR	0.56711166
75	PNCK	0.55742733
76	TAF1	0.52757217
77	CDK19	0.50964390
78	PRKACA	0.49332218
79	PIK3CA	0.48965199
80	PLK3	0.47956111
81	STK11	0.47725990
82	MUSK	0.45571713
83	PKN1	0.45016162
84	CAMK4	0.44851833
85	OBSCN	0.44068488
86	PTK2B	0.43965004
87	FLT3	0.43881093
88	STK3	0.42779585
89	DYRK1A	0.42565899
90	CDK3	0.41944984
91	EPHA3	0.41644486
92	ATM	0.40508160
93	CAMK2A	0.39773731
94	CSNK1D	0.38672716
95	CDC7	0.38453799
96	WEE1	0.38234871
97	PLK1	0.37286587
98	CCNB1	0.36993298
99	RPS6KA4	0.35660331
100	PRKCZ	0.35070897

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.06342184
2	Phototransduction_Homo sapiens_hsa04744	2.98560329
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95048491
4	Butanoate metabolism_Homo sapiens_hsa00650	2.52052360
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.34088329
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.32691264
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25528163
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24135596
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.10738191
10	Protein export_Homo sapiens_hsa03060	2.08867732
11	Caffeine metabolism_Homo sapiens_hsa00232	2.04241459
12	Propanoate metabolism_Homo sapiens_hsa00640	2.02205861
13	Homologous recombination_Homo sapiens_hsa03440	2.00823913
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89831633
15	Parkinsons disease_Homo sapiens_hsa05012	1.89644108
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87923285
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.82936346
18	RNA polymerase_Homo sapiens_hsa03020	1.76783583
19	Nicotine addiction_Homo sapiens_hsa05033	1.69364339
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.67581337
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67220847
22	Basal transcription factors_Homo sapiens_hsa03022	1.66793280
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63546342
24	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59965012
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.51879296
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.50042524
27	Peroxisome_Homo sapiens_hsa04146	1.49828522
28	Olfactory transduction_Homo sapiens_hsa04740	1.45113597
29	RNA degradation_Homo sapiens_hsa03018	1.41987623
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.36481213
31	Taste transduction_Homo sapiens_hsa04742	1.34707883
32	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.31508629
33	Regulation of autophagy_Homo sapiens_hsa04140	1.30694462
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30319432
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.29579011
36	Huntingtons disease_Homo sapiens_hsa05016	1.27590155
37	Ribosome_Homo sapiens_hsa03010	1.12431613
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08365279
39	Alzheimers disease_Homo sapiens_hsa05010	1.06662240
40	Sulfur relay system_Homo sapiens_hsa04122	1.03691169
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03093795
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99422412
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.97003846
44	Morphine addiction_Homo sapiens_hsa05032	0.96678277
45	Insulin secretion_Homo sapiens_hsa04911	0.92877240
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91460163
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90656206
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90527748
49	Circadian entrainment_Homo sapiens_hsa04713	0.89461164
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88373070
51	Purine metabolism_Homo sapiens_hsa00230	0.87949997
52	Retinol metabolism_Homo sapiens_hsa00830	0.86427230
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84769093
54	One carbon pool by folate_Homo sapiens_hsa00670	0.82912780
55	Proteasome_Homo sapiens_hsa03050	0.82397172
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82376546
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.81011748
58	Serotonergic synapse_Homo sapiens_hsa04726	0.80797084
59	GABAergic synapse_Homo sapiens_hsa04727	0.80468259
60	Base excision repair_Homo sapiens_hsa03410	0.77562089
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74333212
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.74036545
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.73875457
64	Metabolic pathways_Homo sapiens_hsa01100	0.73832475
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73339827
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71693219
67	ABC transporters_Homo sapiens_hsa02010	0.71433439
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70707327
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70563395
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.68667989
71	Fatty acid elongation_Homo sapiens_hsa00062	0.68044529
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68015321
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67278319
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66366930
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64395162
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60664771
77	Salivary secretion_Homo sapiens_hsa04970	0.59779822
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58927263
79	Sulfur metabolism_Homo sapiens_hsa00920	0.58008365
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.56444235
81	Asthma_Homo sapiens_hsa05310	0.55738793
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.55603781
83	Fatty acid degradation_Homo sapiens_hsa00071	0.54874620
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.53128490
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52051764
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51982754
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.51715033
88	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49529815
89	Mismatch repair_Homo sapiens_hsa03430	0.48913835
90	Circadian rhythm_Homo sapiens_hsa04710	0.48201002
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46647750
92	RNA transport_Homo sapiens_hsa03013	0.44608760
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44583584
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44069819
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.43908762
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.43549911
97	Cocaine addiction_Homo sapiens_hsa05030	0.41754525
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40399178
99	Long-term depression_Homo sapiens_hsa04730	0.36940582
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.34036986

GUSBP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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