ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.90891151
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.19788782
3	cellular ketone body metabolic process (GO:0046950)	4.14556878
4	response to pheromone (GO:0019236)	4.05901364
5	fucose catabolic process (GO:0019317)	3.80160023
6	L-fucose metabolic process (GO:0042354)	3.80160023
7	L-fucose catabolic process (GO:0042355)	3.80160023
8	neural tube formation (GO:0001841)	3.70135790
9	ketone body metabolic process (GO:1902224)	3.69421298
10	epithelial cilium movement (GO:0003351)	3.62497355
11	protein complex biogenesis (GO:0070271)	3.55587457
12	detection of light stimulus involved in visual perception (GO:0050908)	3.51583575
13	detection of light stimulus involved in sensory perception (GO:0050962)	3.51583575
14	nonmotile primary cilium assembly (GO:0035058)	3.47843809
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.47230138
16	NADH dehydrogenase complex assembly (GO:0010257)	3.47230138
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.47230138
18	protein polyglutamylation (GO:0018095)	3.44151392
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.31787671
20	regulation of cilium movement (GO:0003352)	3.28228856
21	axoneme assembly (GO:0035082)	3.26004966
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21676165
23	kidney morphogenesis (GO:0060993)	3.21495171
24	indole-containing compound catabolic process (GO:0042436)	3.20436724
25	indolalkylamine catabolic process (GO:0046218)	3.20436724
26	tryptophan catabolic process (GO:0006569)	3.20436724
27	preassembly of GPI anchor in ER membrane (GO:0016254)	3.18172644
28	regulation of hexokinase activity (GO:1903299)	3.12337253
29	regulation of glucokinase activity (GO:0033131)	3.12337253
30	intraciliary transport (GO:0042073)	3.11347707
31	indolalkylamine metabolic process (GO:0006586)	3.08917759
32	cornea development in camera-type eye (GO:0061303)	3.06579038
33	replication fork processing (GO:0031297)	3.06145114
34	pyrimidine nucleobase catabolic process (GO:0006208)	3.01552407
35	photoreceptor cell maintenance (GO:0045494)	2.97767846
36	cilium morphogenesis (GO:0060271)	2.95158070
37	regulation of action potential (GO:0098900)	2.94607187
38	kynurenine metabolic process (GO:0070189)	2.94444682
39	DNA methylation involved in gamete generation (GO:0043046)	2.92457928
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.92176926
41	piRNA metabolic process (GO:0034587)	2.91805070
42	respiratory chain complex IV assembly (GO:0008535)	2.89823873
43	cilium organization (GO:0044782)	2.88695921
44	cytochrome complex assembly (GO:0017004)	2.87018729
45	inositol phosphate catabolic process (GO:0071545)	2.86945033
46	DNA deamination (GO:0045006)	2.85044453
47	cilium assembly (GO:0042384)	2.84577786
48	tryptophan metabolic process (GO:0006568)	2.83846843
49	nephron tubule morphogenesis (GO:0072078)	2.82107877
50	nephron epithelium morphogenesis (GO:0072088)	2.82107877
51	cell proliferation in forebrain (GO:0021846)	2.81016817
52	negative regulation of mast cell activation (GO:0033004)	2.80996946
53	protein localization to cilium (GO:0061512)	2.80240399
54	cilium movement (GO:0003341)	2.77500107
55	nucleobase catabolic process (GO:0046113)	2.76154803
56	platelet dense granule organization (GO:0060155)	2.71930568
57	mannosylation (GO:0097502)	2.71051488
58	ubiquinone biosynthetic process (GO:0006744)	2.69734609
59	dendritic spine morphogenesis (GO:0060997)	2.69446571
60	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.68352098
61	regulation of translation, ncRNA-mediated (GO:0045974)	2.68352098
62	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.68352098
63	establishment of protein localization to Golgi (GO:0072600)	2.65535329
64	somite rostral/caudal axis specification (GO:0032525)	2.63294668
65	neuronal action potential (GO:0019228)	2.63220976
66	behavioral response to ethanol (GO:0048149)	2.62971606
67	S-adenosylmethionine metabolic process (GO:0046500)	2.62494357
68	cilium or flagellum-dependent cell motility (GO:0001539)	2.62137230
69	prenylation (GO:0097354)	2.60773953
70	protein prenylation (GO:0018342)	2.60773953
71	amine catabolic process (GO:0009310)	2.57669134
72	cellular biogenic amine catabolic process (GO:0042402)	2.57669134
73	negative regulation of telomere maintenance (GO:0032205)	2.57611498
74	protein localization to Golgi apparatus (GO:0034067)	2.55749766
75	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.54636620
76	reciprocal meiotic recombination (GO:0007131)	2.53996931
77	reciprocal DNA recombination (GO:0035825)	2.53996931
78	GPI anchor metabolic process (GO:0006505)	2.53477422
79	ubiquinone metabolic process (GO:0006743)	2.50087322
80	regulation of microtubule-based movement (GO:0060632)	2.48720791
81	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.47385682
82	inositol phosphate dephosphorylation (GO:0046855)	2.47385682
83	resolution of meiotic recombination intermediates (GO:0000712)	2.46611444
84	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.46487672
85	somite development (GO:0061053)	2.46418380
86	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45261268
87	indole-containing compound metabolic process (GO:0042430)	2.45143260
88	reflex (GO:0060004)	2.43866024
89	polyol catabolic process (GO:0046174)	2.43497340
90	synaptic transmission, cholinergic (GO:0007271)	2.43184397
91	membrane depolarization during action potential (GO:0086010)	2.43034463
92	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.42972358
93	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.42748643
94	retinal ganglion cell axon guidance (GO:0031290)	2.42600331
95	cell differentiation in spinal cord (GO:0021515)	2.39658264
96	primary amino compound metabolic process (GO:1901160)	2.39400893
97	regulation of telomere maintenance (GO:0032204)	2.39143238
98	base-excision repair, AP site formation (GO:0006285)	2.37768400
99	C-terminal protein lipidation (GO:0006501)	2.36424193
100	hindbrain development (GO:0030902)	2.34300546

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.17007173
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.25106051
3	VDR_22108803_ChIP-Seq_LS180_Human	3.22419936
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.88490439
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.77219852
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.66303473
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62667618
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60317668
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42248630
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.41652985
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.27440522
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.15740050
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14736428
14	EWS_26573619_Chip-Seq_HEK293_Human	2.08797772
15	FUS_26573619_Chip-Seq_HEK293_Human	2.05609656
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03450769
17	P300_19829295_ChIP-Seq_ESCs_Human	1.96632860
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87006781
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.86193276
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.83439240
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.81690405
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80154296
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65503171
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.65486887
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.64791048
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64701564
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62099009
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58262606
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57265569
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56515313
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56423368
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55631256
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.53805840
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.52271124
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52271124
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49350694
37	STAT3_23295773_ChIP-Seq_U87_Human	1.48997905
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48117839
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46892317
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46674309
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.46353034
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45348328
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43654681
44	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.42120598
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41544138
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.40904975
47	AR_25329375_ChIP-Seq_VCAP_Human	1.39680246
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.36931106
49	TCF4_23295773_ChIP-Seq_U87_Human	1.35521295
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35098808
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.33734695
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33298338
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31633417
54	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28271110
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27490784
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27409206
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22715010
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22093987
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22093987
60	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.20958356
61	NCOR_22424771_ChIP-Seq_293T_Human	1.20679353
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.20481285
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18491662
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18491662
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18392695
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14127086
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14120321
68	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.13737421
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12398141
70	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11614922
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11522397
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11426072
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11426072
74	AR_21572438_ChIP-Seq_LNCaP_Human	1.11013568
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09181962
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08500117
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08263091
78	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07862433
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07484987
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06405561
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05223166
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05062738
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04500218
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04429664
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03813368
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03260366
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02342493
88	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.01392171
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01301128
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99752644
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99034814
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98933179
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98325420
94	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97537567
95	AR_20517297_ChIP-Seq_VCAP_Human	0.96525335
96	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95550863
97	ERA_21632823_ChIP-Seq_H3396_Human	0.92225378
98	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.91578522
99	ELK1_19687146_ChIP-ChIP_HELA_Human	0.91332542
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.91324957

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.48784966
2	MP0003787_abnormal_imprinting	3.47878173
3	MP0005551_abnormal_eye_electrophysiolog	2.41273781
4	MP0003195_calcinosis	2.30518294
5	MP0002837_dystrophic_cardiac_calcinosis	2.21890479
6	MP0006292_abnormal_olfactory_placode	2.20839179
7	MP0002638_abnormal_pupillary_reflex	2.12409378
8	MP0002735_abnormal_chemical_nociception	2.11803402
9	MP0004133_heterotaxia	2.05096675
10	MP0005645_abnormal_hypothalamus_physiol	2.01694574
11	MP0003880_abnormal_central_pattern	1.98719323
12	MP0006072_abnormal_retinal_apoptosis	1.97072524
13	MP0002102_abnormal_ear_morphology	1.95764428
14	MP0002163_abnormal_gland_morphology	1.90474714
15	MP0003121_genomic_imprinting	1.90082667
16	MP0000569_abnormal_digit_pigmentation	1.89792769
17	MP0001968_abnormal_touch/_nociception	1.89413604
18	MP0005646_abnormal_pituitary_gland	1.87307105
19	MP0009046_muscle_twitch	1.86647640
20	MP0000372_irregular_coat_pigmentation	1.78100026
21	MP0003122_maternal_imprinting	1.74773836
22	MP0006276_abnormal_autonomic_nervous	1.73835178
23	MP0004142_abnormal_muscle_tone	1.69362838
24	MP0002938_white_spotting	1.68424143
25	MP0009745_abnormal_behavioral_response	1.67637543
26	MP0008995_early_reproductive_senescence	1.66868360
27	MP0005253_abnormal_eye_physiology	1.66495927
28	MP0005174_abnormal_tail_pigmentation	1.66237640
29	MP0005379_endocrine/exocrine_gland_phen	1.65826407
30	MP0001986_abnormal_taste_sensitivity	1.65820140
31	MP0005075_abnormal_melanosome_morpholog	1.64867700
32	MP0008872_abnormal_physiological_respon	1.62804891
33	MP0004885_abnormal_endolymph	1.60857659
34	MP0003646_muscle_fatigue	1.54515484
35	MP0002272_abnormal_nervous_system	1.54164359
36	MP0004147_increased_porphyrin_level	1.49680319
37	MP0000631_abnormal_neuroendocrine_gland	1.48943702
38	MP0001485_abnormal_pinna_reflex	1.48627256
39	MP0001529_abnormal_vocalization	1.47538032
40	MP0002736_abnormal_nociception_after	1.47407975
41	MP0002876_abnormal_thyroid_physiology	1.45115803
42	MP0002557_abnormal_social/conspecific_i	1.45098804
43	MP0002653_abnormal_ependyma_morphology	1.42992847
44	MP0003136_yellow_coat_color	1.40805821
45	MP0000427_abnormal_hair_cycle	1.40149549
46	MP0001984_abnormal_olfaction	1.39538206
47	MP0004043_abnormal_pH_regulation	1.39273552
48	MP0002734_abnormal_mechanical_nocicepti	1.37989029
49	MP0001486_abnormal_startle_reflex	1.37737803
50	MP0002822_catalepsy	1.36255592
51	MP0003283_abnormal_digestive_organ	1.35782733
52	MP0002572_abnormal_emotion/affect_behav	1.34448812
53	MP0001970_abnormal_pain_threshold	1.31750466
54	MP0004145_abnormal_muscle_electrophysio	1.29366748
55	MP0000778_abnormal_nervous_system	1.25117954
56	MP0002733_abnormal_thermal_nociception	1.24354439
57	MP0008058_abnormal_DNA_repair	1.21125213
58	MP0002095_abnormal_skin_pigmentation	1.19515260
59	MP0002064_seizures	1.11661271
60	MP0002160_abnormal_reproductive_system	1.10125058
61	MP0002928_abnormal_bile_duct	1.08990649
62	MP0005084_abnormal_gallbladder_morpholo	1.08774843
63	MP0002184_abnormal_innervation	1.08624412
64	MP0005195_abnormal_posterior_eye	1.06479750
65	MP0003718_maternal_effect	1.06169718
66	MP0002067_abnormal_sensory_capabilities	1.06104136
67	MP0003011_delayed_dark_adaptation	1.06058618
68	MP0002234_abnormal_pharynx_morphology	1.04920961
69	MP0005386_behavior/neurological_phenoty	1.04744344
70	MP0004924_abnormal_behavior	1.04744344
71	MP0000015_abnormal_ear_pigmentation	1.03957968
72	MP0002063_abnormal_learning/memory/cond	1.03313115
73	MP0003635_abnormal_synaptic_transmissio	1.01870604
74	MP0002752_abnormal_somatic_nervous	1.01224559
75	MP0005389_reproductive_system_phenotype	1.00158383
76	MP0001324_abnormal_eye_pigmentation	0.99888718
77	MP0003698_abnormal_male_reproductive	0.95862558
78	MP0001501_abnormal_sleep_pattern	0.94754867
79	MP0002909_abnormal_adrenal_gland	0.94159029
80	MP0002751_abnormal_autonomic_nervous	0.93430901
81	MP0005410_abnormal_fertilization	0.92691643
82	MP0008875_abnormal_xenobiotic_pharmacok	0.92486566
83	MP0004742_abnormal_vestibular_system	0.91970783
84	MP0001905_abnormal_dopamine_level	0.91441441
85	MP0010386_abnormal_urinary_bladder	0.90339205
86	MP0001944_abnormal_pancreas_morphology	0.89842285
87	MP0008789_abnormal_olfactory_epithelium	0.88389041
88	MP0003123_paternal_imprinting	0.87758868
89	MP0002229_neurodegeneration	0.82980208
90	MP0005171_absent_coat_pigmentation	0.82526629
91	MP0001929_abnormal_gametogenesis	0.82260239
92	MP0005423_abnormal_somatic_nervous	0.82149743
93	MP0001963_abnormal_hearing_physiology	0.81858913
94	MP0000955_abnormal_spinal_cord	0.81510746
95	MP0000026_abnormal_inner_ear	0.81003279
96	MP0002210_abnormal_sex_determination	0.80517672
97	MP0003890_abnormal_embryonic-extraembry	0.79909153
98	MP0002882_abnormal_neuron_morphology	0.77650201
99	MP0005220_abnormal_exocrine_pancreas	0.77108243
100	MP0008775_abnormal_heart_ventricle	0.75429118

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38463469
2	Pancreatic fibrosis (HP:0100732)	4.34824486
3	Congenital stationary night blindness (HP:0007642)	4.07246109
4	Abnormality of midbrain morphology (HP:0002418)	4.07069857
5	Molar tooth sign on MRI (HP:0002419)	4.07069857
6	True hermaphroditism (HP:0010459)	3.92615070
7	Nephronophthisis (HP:0000090)	3.91200613
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.44430720
9	Chronic hepatic failure (HP:0100626)	3.39492827
10	Medial flaring of the eyebrow (HP:0010747)	3.38282760
11	Abnormality of the renal medulla (HP:0100957)	3.37907695
12	Abnormality of the renal cortex (HP:0011035)	3.22804050
13	Abnormal drinking behavior (HP:0030082)	3.11048311
14	Polydipsia (HP:0001959)	3.11048311
15	Type II lissencephaly (HP:0007260)	3.03780208
16	Tubular atrophy (HP:0000092)	3.02290471
17	Cystic liver disease (HP:0006706)	2.91127891
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.87019366
19	Gait imbalance (HP:0002141)	2.84072125
20	Congenital primary aphakia (HP:0007707)	2.69492714
21	Hyperventilation (HP:0002883)	2.69440874
22	Attenuation of retinal blood vessels (HP:0007843)	2.65248144
23	Nephrogenic diabetes insipidus (HP:0009806)	2.55344132
24	Broad-based gait (HP:0002136)	2.53296549
25	Polyuria (HP:0000103)	2.49917007
26	Cerebellar dysplasia (HP:0007033)	2.48669937
27	Bile duct proliferation (HP:0001408)	2.40939256
28	Abnormal biliary tract physiology (HP:0012439)	2.40939256
29	Congenital hepatic fibrosis (HP:0002612)	2.35543909
30	Decreased central vision (HP:0007663)	2.34553507
31	Sclerocornea (HP:0000647)	2.33379182
32	Hypothermia (HP:0002045)	2.32813931
33	Lissencephaly (HP:0001339)	2.31640610
34	Anencephaly (HP:0002323)	2.28881381
35	Abolished electroretinogram (ERG) (HP:0000550)	2.24159689
36	Mitochondrial inheritance (HP:0001427)	2.21354895
37	Acute necrotizing encephalopathy (HP:0006965)	2.17386060
38	Genetic anticipation (HP:0003743)	2.14965797
39	Intestinal atresia (HP:0011100)	2.14658061
40	Pendular nystagmus (HP:0012043)	2.13559529
41	Progressive cerebellar ataxia (HP:0002073)	2.13460594
42	Renal cortical cysts (HP:0000803)	2.13337182
43	Postaxial foot polydactyly (HP:0001830)	2.12450861
44	Increased CSF lactate (HP:0002490)	2.12308560
45	Gaze-evoked nystagmus (HP:0000640)	2.10408640
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.09183902
47	Genital tract atresia (HP:0001827)	2.08681149
48	Severe visual impairment (HP:0001141)	2.07558383
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07312866
50	Vaginal atresia (HP:0000148)	2.05042022
51	Male pseudohermaphroditism (HP:0000037)	2.03143997
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.01801648
53	Hypoplasia of the fovea (HP:0007750)	2.01801648
54	Abnormality of the labia minora (HP:0012880)	2.00435884
55	Poor coordination (HP:0002370)	2.00202095
56	Hepatic necrosis (HP:0002605)	1.99952064
57	Agitation (HP:0000713)	1.99563572
58	Acute encephalopathy (HP:0006846)	1.98711059
59	Lipid accumulation in hepatocytes (HP:0006561)	1.97995846
60	Bony spicule pigmentary retinopathy (HP:0007737)	1.97494914
61	Abnormality of the renal collecting system (HP:0004742)	1.97459696
62	Abnormal urine output (HP:0012590)	1.97385400
63	Hypomagnesemia (HP:0002917)	1.96517448
64	Occipital encephalocele (HP:0002085)	1.96059455
65	Postaxial hand polydactyly (HP:0001162)	1.95446303
66	Progressive macrocephaly (HP:0004481)	1.94971209
67	Ketosis (HP:0001946)	1.93784985
68	Methylmalonic acidemia (HP:0002912)	1.92967682
69	Large for gestational age (HP:0001520)	1.92961370
70	Pachygyria (HP:0001302)	1.92184751
71	Polyphagia (HP:0002591)	1.91242983
72	Abnormality of the pons (HP:0007361)	1.90444450
73	Hepatocellular necrosis (HP:0001404)	1.90442903
74	Hypoplasia of the pons (HP:0012110)	1.89744175
75	Furrowed tongue (HP:0000221)	1.89339866
76	Asplenia (HP:0001746)	1.88935280
77	Colon cancer (HP:0003003)	1.88167466
78	Optic nerve hypoplasia (HP:0000609)	1.88144003
79	Febrile seizures (HP:0002373)	1.86415870
80	Ketoacidosis (HP:0001993)	1.85920162
81	Inability to walk (HP:0002540)	1.80688285
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79517831
83	Abnormality of alanine metabolism (HP:0010916)	1.79517831
84	Hyperalaninemia (HP:0003348)	1.79517831
85	Protruding tongue (HP:0010808)	1.78485630
86	Abnormal mitochondria in muscle tissue (HP:0008316)	1.78208780
87	Abnormality of renal excretion (HP:0011036)	1.77916446
88	Hemiparesis (HP:0001269)	1.76349269
89	Oligodactyly (hands) (HP:0001180)	1.76069533
90	Optic disc pallor (HP:0000543)	1.75170755
91	Abnormality of macular pigmentation (HP:0008002)	1.74864880
92	Glycosuria (HP:0003076)	1.73830858
93	Abnormality of urine glucose concentration (HP:0011016)	1.73830858
94	Albinism (HP:0001022)	1.72415243
95	Tachypnea (HP:0002789)	1.71492500
96	Progressive inability to walk (HP:0002505)	1.70584459
97	Astigmatism (HP:0000483)	1.70550199
98	Supernumerary spleens (HP:0009799)	1.70114676
99	Increased hepatocellular lipid droplets (HP:0006565)	1.70048185
100	Duplicated collecting system (HP:0000081)	1.69994581

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.32335682
2	MAP4K2	3.53541383
3	TRIM28	2.78786656
4	WNK3	2.76942573
5	ADRBK2	2.59994950
6	BMPR1B	2.54652088
7	GRK1	2.53587433
8	MAP3K4	2.35875346
9	WNK4	2.33802231
10	CASK	2.31603092
11	MAPK13	2.21217937
12	BCKDK	2.20519117
13	TNIK	2.12325180
14	INSRR	2.03798956
15	ZAK	2.03347656
16	NUAK1	2.01463286
17	PINK1	1.91636885
18	ACVR1B	1.78588559
19	STK39	1.70038813
20	MAP2K7	1.53306513
21	PAK3	1.47221311
22	OXSR1	1.45742378
23	MKNK2	1.43619808
24	TAOK3	1.40975862
25	DAPK2	1.34121411
26	MARK1	1.32963401
27	DYRK2	1.28257630
28	TLK1	1.22342105
29	AKT3	1.12445547
30	PHKG1	1.00885610
31	PHKG2	1.00885610
32	NTRK3	0.98314503
33	CAMKK2	0.95551149
34	PRKD3	0.91581533
35	PRKCG	0.91151453
36	FGFR2	0.89837599
37	PRKCE	0.89632716
38	MUSK	0.89001827
39	CSNK1G2	0.85569449
40	ADRBK1	0.82838248
41	EPHA4	0.81555200
42	DYRK3	0.80881222
43	VRK1	0.80852877
44	CSNK1A1L	0.80709982
45	CSNK1G1	0.79165564
46	CSNK1G3	0.78794314
47	TNK2	0.77862461
48	MAP2K4	0.74950184
49	ERBB3	0.72453475
50	STK11	0.70268836
51	BCR	0.69697458
52	FER	0.69605247
53	STK3	0.69170572
54	TXK	0.69058888
55	PNCK	0.66094213
56	PLK2	0.65188396
57	TEC	0.62450916
58	NTRK2	0.61664374
59	STK16	0.61167187
60	BRSK2	0.60572801
61	CAMK1	0.60539525
62	MKNK1	0.60120169
63	CAMK1G	0.58860103
64	PTK2B	0.58740793
65	PIK3CA	0.57775366
66	PRKCH	0.55510773
67	TIE1	0.54368346
68	SGK2	0.53457503
69	PRKCI	0.53121763
70	ATR	0.52782756
71	MAP2K6	0.52760095
72	PRKAA1	0.52388644
73	PRKACA	0.51750457
74	SGK223	0.48534422
75	SGK494	0.48534422
76	CSNK1A1	0.47439797
77	FLT3	0.47330286
78	TGFBR1	0.46505566
79	DYRK1A	0.46487735
80	RPS6KA5	0.46045428
81	PRKCQ	0.45674861
82	PRKCZ	0.45563178
83	CAMK2A	0.44418040
84	CAMK1D	0.44175014
85	CAMK2D	0.43710148
86	SIK2	0.43679130
87	EPHA3	0.42810284
88	EIF2AK3	0.41704279
89	PLK3	0.40682545
90	MST4	0.38103157
91	CSNK1D	0.37867857
92	PRKG1	0.35166911
93	CAMK4	0.34677835
94	ATM	0.34464399
95	PRKAA2	0.34285578
96	CHUK	0.34271283
97	PRKCA	0.33995265
98	MARK3	0.33167218
99	VRK2	0.33072646
100	MINK1	0.32711426

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.19810972
2	Phototransduction_Homo sapiens_hsa04744	2.86124959
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.82132399
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.75477654
5	Butanoate metabolism_Homo sapiens_hsa00650	2.47563143
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41202370
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32852227
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28301198
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.13864794
10	Nicotine addiction_Homo sapiens_hsa05033	2.09117846
11	Ether lipid metabolism_Homo sapiens_hsa00565	1.88208383
12	Basal transcription factors_Homo sapiens_hsa03022	1.85691579
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.85639565
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84529160
15	Propanoate metabolism_Homo sapiens_hsa00640	1.73604914
16	Homologous recombination_Homo sapiens_hsa03440	1.71302664
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66224029
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65713597
19	Parkinsons disease_Homo sapiens_hsa05012	1.63832996
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63535500
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.62262660
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.61855678
23	RNA polymerase_Homo sapiens_hsa03020	1.60827648
24	Protein export_Homo sapiens_hsa03060	1.60223836
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52944813
26	Olfactory transduction_Homo sapiens_hsa04740	1.45805521
27	Insulin secretion_Homo sapiens_hsa04911	1.43866823
28	Caffeine metabolism_Homo sapiens_hsa00232	1.43140183
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.40197987
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39459581
31	Peroxisome_Homo sapiens_hsa04146	1.37723837
32	Taste transduction_Homo sapiens_hsa04742	1.36267515
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35755007
34	Morphine addiction_Homo sapiens_hsa05032	1.31358678
35	Regulation of autophagy_Homo sapiens_hsa04140	1.27389298
36	Huntingtons disease_Homo sapiens_hsa05016	1.27201092
37	RNA degradation_Homo sapiens_hsa03018	1.22496674
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19936832
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16217112
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.16191843
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11410517
42	GABAergic synapse_Homo sapiens_hsa04727	1.09822536
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.06453223
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.06106758
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04418992
46	Alzheimers disease_Homo sapiens_hsa05010	1.02252834
47	Serotonergic synapse_Homo sapiens_hsa04726	1.02007988
48	Circadian entrainment_Homo sapiens_hsa04713	1.00892597
49	Retinol metabolism_Homo sapiens_hsa00830	0.95267567
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.95253386
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91109495
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90974925
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88578361
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87728063
55	One carbon pool by folate_Homo sapiens_hsa00670	0.87401342
56	Sulfur relay system_Homo sapiens_hsa04122	0.86095427
57	ABC transporters_Homo sapiens_hsa02010	0.85857365
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.84754067
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83441231
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.82254228
61	Dopaminergic synapse_Homo sapiens_hsa04728	0.80115649
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78475906
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.76296825
64	Histidine metabolism_Homo sapiens_hsa00340	0.74619463
65	Metabolic pathways_Homo sapiens_hsa01100	0.71915431
66	Purine metabolism_Homo sapiens_hsa00230	0.68790662
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66815690
68	Salivary secretion_Homo sapiens_hsa04970	0.61002414
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57693090
70	Sulfur metabolism_Homo sapiens_hsa00920	0.57425066
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.57074730
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53905030
73	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53841821
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.53369941
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53206839
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53205405
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52969279
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52937597
79	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49130795
80	Long-term depression_Homo sapiens_hsa04730	0.48715701
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46674147
82	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46080963
83	Cholinergic synapse_Homo sapiens_hsa04725	0.45382171
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44996221
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42589843
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40783025
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40576829
88	Fatty acid degradation_Homo sapiens_hsa00071	0.39797356
89	Mineral absorption_Homo sapiens_hsa04978	0.39742184
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38097334
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37601925
92	Fatty acid elongation_Homo sapiens_hsa00062	0.36573738
93	Amphetamine addiction_Homo sapiens_hsa05031	0.36325729
94	Folate biosynthesis_Homo sapiens_hsa00790	0.36321473
95	Lysine degradation_Homo sapiens_hsa00310	0.36283394
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.35866954
97	Renin secretion_Homo sapiens_hsa04924	0.35829989
98	Cocaine addiction_Homo sapiens_hsa05030	0.34062868
99	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.33923351
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32782446

GUSBP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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