ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	arginine catabolic process (GO:0006527)	5.05866661
2	response to pheromone (GO:0019236)	4.67233209
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.59507311
4	tachykinin receptor signaling pathway (GO:0007217)	4.36136323
5	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.12430412
6	DNA integration (GO:0015074)	4.12067740
7	platelet dense granule organization (GO:0060155)	4.02770522
8	respiratory chain complex IV assembly (GO:0008535)	3.90473018
9	positive regulation of cell size (GO:0045793)	3.88268913
10	iron-sulfur cluster assembly (GO:0016226)	3.78502202
11	metallo-sulfur cluster assembly (GO:0031163)	3.78502202
12	positive regulation of mitochondrial fission (GO:0090141)	3.75678347
13	epithelial cilium movement (GO:0003351)	3.65115041
14	arginine metabolic process (GO:0006525)	3.64618443
15	exogenous drug catabolic process (GO:0042738)	3.58940844
16	drug catabolic process (GO:0042737)	3.58073180
17	negative regulation of neurotransmitter transport (GO:0051589)	3.57491820
18	regulation of neurotransmitter uptake (GO:0051580)	3.57264220
19	positive regulation of guanylate cyclase activity (GO:0031284)	3.56981110
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.56691659
21	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	3.53879321
22	cytochrome complex assembly (GO:0017004)	3.51658902
23	pyrimidine nucleobase catabolic process (GO:0006208)	3.49607592
24	regulation of cilium movement (GO:0003352)	3.48323255
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.44351774
26	mannosylation (GO:0097502)	3.43344407
27	ubiquinone biosynthetic process (GO:0006744)	3.41763838
28	response to lipoprotein particle (GO:0055094)	3.40829871
29	nonmotile primary cilium assembly (GO:0035058)	3.31701295
30	regulation of mitochondrial translation (GO:0070129)	3.30375525
31	positive regulation of action potential (GO:0045760)	3.29507999
32	retinal cone cell development (GO:0046549)	3.27205933
33	C-terminal protein lipidation (GO:0006501)	3.15639557
34	ubiquinone metabolic process (GO:0006743)	3.12405198
35	regulation of guanylate cyclase activity (GO:0031282)	3.11437914
36	C4-dicarboxylate transport (GO:0015740)	3.10529779
37	peptidyl-histidine modification (GO:0018202)	3.09522779
38	positive regulation of mRNA catabolic process (GO:0061014)	3.08358391
39	CTP metabolic process (GO:0046036)	3.07119337
40	CTP biosynthetic process (GO:0006241)	3.07119337
41	L-methionine salvage (GO:0071267)	3.03900798
42	L-methionine biosynthetic process (GO:0071265)	3.03900798
43	amino acid salvage (GO:0043102)	3.03900798
44	axoneme assembly (GO:0035082)	3.03738422
45	cellular ketone body metabolic process (GO:0046950)	3.03586724
46	limb bud formation (GO:0060174)	3.02813885
47	regulation of action potential (GO:0098900)	3.01605680
48	histone H2A acetylation (GO:0043968)	3.00879492
49	somite development (GO:0061053)	3.00401880
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99770061
51	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.96035149
52	photoreceptor cell maintenance (GO:0045494)	2.95743765
53	S-adenosylmethionine metabolic process (GO:0046500)	2.95681760
54	glial cell proliferation (GO:0014009)	2.92477406
55	nucleobase catabolic process (GO:0046113)	2.91229648
56	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.90838300
57	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.90838300
58	C-terminal protein amino acid modification (GO:0018410)	2.89706770
59	glyoxylate metabolic process (GO:0046487)	2.88129564
60	negative regulation of neurological system process (GO:0031645)	2.86906098
61	establishment of protein localization to Golgi (GO:0072600)	2.86297583
62	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	2.84736926
63	regulation of mRNA catabolic process (GO:0061013)	2.82287278
64	neural tube formation (GO:0001841)	2.81922975
65	quinone biosynthetic process (GO:1901663)	2.79920025
66	GPI anchor metabolic process (GO:0006505)	2.79522796
67	ketone body metabolic process (GO:1902224)	2.79185712
68	peptidyl-cysteine modification (GO:0018198)	2.78730385
69	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.77469085
70	UMP biosynthetic process (GO:0006222)	2.77469085
71	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.77469085
72	UMP metabolic process (GO:0046049)	2.77469085
73	protein targeting to Golgi (GO:0000042)	2.75707959
74	regulation of mitotic spindle checkpoint (GO:1903504)	2.75540680
75	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.75540680
76	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.74682103
77	positive regulation of receptor biosynthetic process (GO:0010870)	2.73911806
78	aggressive behavior (GO:0002118)	2.73080518
79	protein polyglutamylation (GO:0018095)	2.72413438
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.72333146
81	detection of light stimulus involved in visual perception (GO:0050908)	2.72333146
82	fucose catabolic process (GO:0019317)	2.71209727
83	L-fucose metabolic process (GO:0042354)	2.71209727
84	L-fucose catabolic process (GO:0042355)	2.71209727
85	protein deneddylation (GO:0000338)	2.70581289
86	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.69537212
87	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	2.69069967
88	cilium movement (GO:0003341)	2.66705499
89	base-excision repair, AP site formation (GO:0006285)	2.66431342
90	establishment of mitochondrion localization (GO:0051654)	2.65566807
91	DNA deamination (GO:0045006)	2.65248637
92	branched-chain amino acid catabolic process (GO:0009083)	2.64956560
93	protein localization to Golgi apparatus (GO:0034067)	2.64819643
94	protein complex biogenesis (GO:0070271)	2.64468274
95	DNA double-strand break processing (GO:0000729)	2.63578357
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.62618862
97	gamma-aminobutyric acid transport (GO:0015812)	2.61351350
98	replication fork processing (GO:0031297)	2.59542394
99	axonal fasciculation (GO:0007413)	2.56077106
100	cullin deneddylation (GO:0010388)	2.54847728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	5.04383301
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.27697499
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20723807
4	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.96914494
5	FUS_26573619_Chip-Seq_HEK293_Human	2.77169100
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.73489041
7	VDR_22108803_ChIP-Seq_LS180_Human	2.65017492
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54985369
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51528450
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.45199429
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.37631426
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.28372064
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26646692
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16321922
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.04947071
16	EWS_26573619_Chip-Seq_HEK293_Human	2.00564152
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98447172
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.89900446
19	CBP_20019798_ChIP-Seq_JUKART_Human	1.84304761
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.84304761
21	P300_19829295_ChIP-Seq_ESCs_Human	1.81605256
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79378646
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77278132
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70662840
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64352809
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.64321164
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63505649
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62178406
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60128200
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59079580
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56808518
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56174288
33	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52140695
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.51308195
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.47535452
36	STAT3_23295773_ChIP-Seq_U87_Human	1.47328425
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.44171265
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42684495
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38407170
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.36240650
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.36089458
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.34288337
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.33838676
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.31012938
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29262333
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28573072
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28483619
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.27856641
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27673865
50	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.25902159
51	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25671961
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25663989
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25663989
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23222348
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.22904660
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22612314
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21588913
58	TCF4_23295773_ChIP-Seq_U87_Human	1.19202980
59	AR_25329375_ChIP-Seq_VCAP_Human	1.18995333
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18988742
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17472129
62	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.16435437
63	ERA_21632823_ChIP-Seq_H3396_Human	1.15631941
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14817222
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.13181630
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13135770
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.12352460
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10270173
69	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.08789278
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08457265
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07539583
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06911436
73	AR_20517297_ChIP-Seq_VCAP_Human	1.05428539
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.04211511
75	GATA3_26560356_Chip-Seq_TH2_Human	1.03864076
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.03094866
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02561531
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00959352
79	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00912402
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00051362
81	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99761572
82	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99404293
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99251793
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99159469
85	JUN_21703547_ChIP-Seq_K562_Human	0.98414562
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97886560
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97675236
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96938649
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96687275
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.96503431
91	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.96035566
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95635622
93	GABP_19822575_ChIP-Seq_HepG2_Human	0.94315311
94	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.93352323
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92359462
96	NCOR_22424771_ChIP-Seq_293T_Human	0.91682007
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91472025
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91472025
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90706400
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90191003

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.37231471
2	MP0002234_abnormal_pharynx_morphology	4.15587212
3	MP0005645_abnormal_hypothalamus_physiol	3.08753022
4	MP0008058_abnormal_DNA_repair	2.69408328
5	MP0003718_maternal_effect	2.53601002
6	MP0002822_catalepsy	2.48305757
7	MP0002736_abnormal_nociception_after	2.42944112
8	MP0001968_abnormal_touch/_nociception	2.36090889
9	MP0004043_abnormal_pH_regulation	2.32110280
10	MP0003880_abnormal_central_pattern	2.31893287
11	MP0001986_abnormal_taste_sensitivity	2.26224845
12	MP0001984_abnormal_olfaction	2.22023845
13	MP0002735_abnormal_chemical_nociception	2.17357970
14	MP0004133_heterotaxia	1.95872809
15	MP0005167_abnormal_blood-brain_barrier	1.94366624
16	MP0005551_abnormal_eye_electrophysiolog	1.93258703
17	MP0008872_abnormal_physiological_respon	1.85159234
18	MP0010368_abnormal_lymphatic_system	1.84148322
19	MP0002102_abnormal_ear_morphology	1.82395016
20	MP0005253_abnormal_eye_physiology	1.80045221
21	MP0002638_abnormal_pupillary_reflex	1.80025752
22	MP0006072_abnormal_retinal_apoptosis	1.78579212
23	MP0008877_abnormal_DNA_methylation	1.77549030
24	MP0000566_synostosis	1.75271171
25	MP0004233_abnormal_muscle_weight	1.74595823
26	MP0000372_irregular_coat_pigmentation	1.68864347
27	MP0001529_abnormal_vocalization	1.65637975
28	MP0006276_abnormal_autonomic_nervous	1.65432255
29	MP0001764_abnormal_homeostasis	1.62135717
30	MP0005075_abnormal_melanosome_morpholog	1.57058811
31	MP0002837_dystrophic_cardiac_calcinosis	1.50876368
32	MP0005499_abnormal_olfactory_system	1.49692081
33	MP0005394_taste/olfaction_phenotype	1.49692081
34	MP0008789_abnormal_olfactory_epithelium	1.46636816
35	MP0001919_abnormal_reproductive_system	1.46492410
36	MP0008995_early_reproductive_senescence	1.40418379
37	MP0003011_delayed_dark_adaptation	1.38137577
38	MP0005367_renal/urinary_system_phenotyp	1.37994392
39	MP0000516_abnormal_urinary_system	1.37994392
40	MP0009745_abnormal_behavioral_response	1.37254920
41	MP0005670_abnormal_white_adipose	1.35760916
42	MP0010386_abnormal_urinary_bladder	1.34798874
43	MP0003195_calcinosis	1.30129569
44	MP0002751_abnormal_autonomic_nervous	1.27085259
45	MP0001486_abnormal_startle_reflex	1.27078082
46	MP0001970_abnormal_pain_threshold	1.24783106
47	MP0005423_abnormal_somatic_nervous	1.24266286
48	MP0008775_abnormal_heart_ventricle	1.23105096
49	MP0002734_abnormal_mechanical_nocicepti	1.20524669
50	MP0009046_muscle_twitch	1.16565517
51	MP0005386_behavior/neurological_phenoty	1.16258536
52	MP0004924_abnormal_behavior	1.16258536
53	MP0003787_abnormal_imprinting	1.12107215
54	MP0005389_reproductive_system_phenotype	1.08788399
55	MP0002233_abnormal_nose_morphology	1.06156403
56	MP0000631_abnormal_neuroendocrine_gland	1.05951942
57	MP0001501_abnormal_sleep_pattern	1.05241294
58	MP0005084_abnormal_gallbladder_morpholo	1.05099648
59	MP0002272_abnormal_nervous_system	1.02851498
60	MP0000569_abnormal_digit_pigmentation	1.01161730
61	MP0004270_analgesia	0.99317177
62	MP0004084_abnormal_cardiac_muscle	0.98761134
63	MP0004858_abnormal_nervous_system	0.97640196
64	MP0003698_abnormal_male_reproductive	0.96201552
65	MP0003786_premature_aging	0.95848322
66	MP0005410_abnormal_fertilization	0.94529100
67	MP0002572_abnormal_emotion/affect_behav	0.93947158
68	MP0005395_other_phenotype	0.91968375
69	MP0004859_abnormal_synaptic_plasticity	0.91500585
70	MP0010329_abnormal_lipoprotein_level	0.89758076
71	MP0002938_white_spotting	0.89659679
72	MP0005220_abnormal_exocrine_pancreas	0.88273724
73	MP0000465_gastrointestinal_hemorrhage	0.87911903
74	MP0002557_abnormal_social/conspecific_i	0.84271392
75	MP0001929_abnormal_gametogenesis	0.83898855
76	MP0006035_abnormal_mitochondrial_morpho	0.83829609
77	MP0002067_abnormal_sensory_capabilities	0.83547341
78	MP0002653_abnormal_ependyma_morphology	0.83345384
79	MP0004147_increased_porphyrin_level	0.82943710
80	MP0002733_abnormal_thermal_nociception	0.82880759
81	MP0000955_abnormal_spinal_cord	0.81571620
82	MP0000778_abnormal_nervous_system	0.81202712
83	MP0004885_abnormal_endolymph	0.80066610
84	MP0004484_altered_response_of	0.79215144
85	MP0002752_abnormal_somatic_nervous	0.78700074
86	MP0005646_abnormal_pituitary_gland	0.78494330
87	MP0004811_abnormal_neuron_physiology	0.77392073
88	MP0004142_abnormal_muscle_tone	0.76716916
89	MP0001756_abnormal_urination	0.74474638
90	MP0003635_abnormal_synaptic_transmissio	0.73813333
91	MP0001119_abnormal_female_reproductive	0.72507913
92	MP0000647_abnormal_sebaceous_gland	0.72099996
93	MP0001905_abnormal_dopamine_level	0.71656102
94	MP0000383_abnormal_hair_follicle	0.71197567
95	MP0002064_seizures	0.70405554
96	MP0000653_abnormal_sex_gland	0.69887381
97	MP0002882_abnormal_neuron_morphology	0.69863317
98	MP0005391_vision/eye_phenotype	0.69159399
99	MP0003121_genomic_imprinting	0.68647531
100	MP0001324_abnormal_eye_pigmentation	0.68293844

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.17792649
2	Anal stenosis (HP:0002025)	3.86272445
3	Medial flaring of the eyebrow (HP:0010747)	3.45381842
4	Lip pit (HP:0100267)	3.43435474
5	Gait imbalance (HP:0002141)	3.40591258
6	Congenital primary aphakia (HP:0007707)	3.38860672
7	Hyperventilation (HP:0002883)	3.31399841
8	Depressed nasal tip (HP:0000437)	3.10331666
9	Chronic hepatic failure (HP:0100626)	3.09134298
10	Pancreatic fibrosis (HP:0100732)	3.06240803
11	Nephrogenic diabetes insipidus (HP:0009806)	3.05137172
12	True hermaphroditism (HP:0010459)	2.98630199
13	Short 5th finger (HP:0009237)	2.92197814
14	Sparse lateral eyebrow (HP:0005338)	2.91160672
15	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.85190637
16	Congenital stationary night blindness (HP:0007642)	2.77489920
17	Renal cortical cysts (HP:0000803)	2.75559375
18	Autoimmune thrombocytopenia (HP:0001973)	2.72529958
19	Bile duct proliferation (HP:0001408)	2.66992349
20	Abnormal biliary tract physiology (HP:0012439)	2.66992349
21	Intestinal fistula (HP:0100819)	2.62606073
22	Abnormality of the renal cortex (HP:0011035)	2.60467005
23	Cerebellar dysplasia (HP:0007033)	2.59776346
24	Atonic seizures (HP:0010819)	2.57997470
25	Posterior subcapsular cataract (HP:0007787)	2.56997859
26	Severe visual impairment (HP:0001141)	2.52035407
27	Poor coordination (HP:0002370)	2.47375375
28	Lissencephaly (HP:0001339)	2.46658658
29	Vaginal atresia (HP:0000148)	2.45334315
30	Nephronophthisis (HP:0000090)	2.44875936
31	Genital tract atresia (HP:0001827)	2.44795928
32	Molar tooth sign on MRI (HP:0002419)	2.44168767
33	Abnormality of midbrain morphology (HP:0002418)	2.44168767
34	Progressive microcephaly (HP:0000253)	2.42320919
35	Intestinal atresia (HP:0011100)	2.35547371
36	Type II lissencephaly (HP:0007260)	2.26997762
37	Abnormality of the renal medulla (HP:0100957)	2.26051222
38	Cystic liver disease (HP:0006706)	2.24183518
39	Pachygyria (HP:0001302)	2.22990087
40	Ectropion (HP:0000656)	2.22148728
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21703503
42	Methylmalonic acidemia (HP:0002912)	2.21245015
43	Hyperglycinemia (HP:0002154)	2.20968703
44	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.19467327
45	Short 1st metacarpal (HP:0010034)	2.19467327
46	Hepatic necrosis (HP:0002605)	2.16842290
47	Ureteral stenosis (HP:0000071)	2.11216714
48	Absent speech (HP:0001344)	2.09310670
49	Hepatocellular necrosis (HP:0001404)	2.09224234
50	Decreased central vision (HP:0007663)	2.07281177
51	Attenuation of retinal blood vessels (HP:0007843)	2.07041054
52	Acute encephalopathy (HP:0006846)	2.04828563
53	Postaxial hand polydactyly (HP:0001162)	2.03570914
54	Abnormal protein glycosylation (HP:0012346)	2.03233704
55	Abnormal glycosylation (HP:0012345)	2.03233704
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03233704
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.03233704
58	Methylmalonic aciduria (HP:0012120)	2.02021890
59	3-Methylglutaconic aciduria (HP:0003535)	2.01437620
60	Febrile seizures (HP:0002373)	2.01344481
61	Popliteal pterygium (HP:0009756)	1.99265459
62	Acute necrotizing encephalopathy (HP:0006965)	1.96626162
63	Long clavicles (HP:0000890)	1.96280785
64	Occipital encephalocele (HP:0002085)	1.95832198
65	Ureteral obstruction (HP:0006000)	1.95305392
66	Type 2 muscle fiber atrophy (HP:0003554)	1.95218229
67	Anal atresia (HP:0002023)	1.94010932
68	Abnormality of macular pigmentation (HP:0008002)	1.92753086
69	Retinal dysplasia (HP:0007973)	1.91196059
70	Increased serum lactate (HP:0002151)	1.91079228
71	Anencephaly (HP:0002323)	1.90993254
72	Poor head control (HP:0002421)	1.90023800
73	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.89725019
74	Abnormality of the 1st metacarpal (HP:0010009)	1.89126882
75	Abnormality of the fingertips (HP:0001211)	1.87889652
76	Mitochondrial inheritance (HP:0001427)	1.87139797
77	Ectopic kidney (HP:0000086)	1.86972023
78	Broad foot (HP:0001769)	1.86872124
79	Supernumerary spleens (HP:0009799)	1.86642815
80	Specific learning disability (HP:0001328)	1.86033978
81	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85778168
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.85086297
83	Abolished electroretinogram (ERG) (HP:0000550)	1.84884243
84	Increased CSF lactate (HP:0002490)	1.84494706
85	Keratoconus (HP:0000563)	1.84147910
86	Increased corneal curvature (HP:0100692)	1.84147910
87	Tented upper lip vermilion (HP:0010804)	1.80722460
88	Bifid tongue (HP:0010297)	1.80484804
89	Proximal tubulopathy (HP:0000114)	1.80273695
90	Abnormal rod and cone electroretinograms (HP:0008323)	1.80060823
91	Sclerocornea (HP:0000647)	1.79991335
92	Hemiparesis (HP:0001269)	1.78653655
93	Postaxial foot polydactyly (HP:0001830)	1.78609051
94	Fibular aplasia (HP:0002990)	1.77838434
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.77280298
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77280298
97	Short phalanx of the thumb (HP:0009660)	1.76502947
98	Abnormality of the parathyroid morphology (HP:0011766)	1.75567494
99	Tubulointerstitial nephritis (HP:0001970)	1.75395162
100	Abnormality of the labia minora (HP:0012880)	1.74901573

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.11505282
2	PINK1	4.09291411
3	STK24	3.17871486
4	STK39	3.06015162
5	WNK4	2.84281667
6	CCNB1	2.77934201
7	ZAK	2.67538337
8	FRK	2.60354844
9	MAPK13	2.56515387
10	BCKDK	2.48084730
11	MAP3K4	2.15376664
12	WNK3	2.13276664
13	BMPR1B	2.06794535
14	NUAK1	2.01346691
15	CASK	1.86797025
16	MAPKAPK3	1.86510768
17	MAP2K7	1.81699225
18	MARK1	1.81676868
19	TAOK3	1.73302561
20	GRK1	1.57109147
21	CSNK1G3	1.53105036
22	TNIK	1.48670152
23	TRIM28	1.42052011
24	CSNK1A1L	1.41083991
25	FLT3	1.37601090
26	CSNK1G2	1.31348960
27	CSNK1G1	1.28096476
28	PDK2	1.23645528
29	BCR	1.20454152
30	EPHA4	1.19593394
31	DYRK3	1.17734121
32	ERBB3	1.17102401
33	ACVR1B	1.14537766
34	INSRR	1.13962398
35	ADRBK2	1.13944244
36	CAMKK2	1.08953637
37	SRPK1	1.08085618
38	EEF2K	1.05862796
39	AKT3	1.04928315
40	JAK3	0.98132820
41	TXK	0.95948017
42	EPHA3	0.95238241
43	PAK3	0.89678963
44	CAMK1	0.88889655
45	PRKCQ	0.88014232
46	KIT	0.87350124
47	CAMK4	0.87192739
48	PIM2	0.78345704
49	NTRK2	0.77289385
50	MAP3K2	0.75781762
51	PRKCE	0.72779438
52	MAP3K3	0.70008018
53	FER	0.68227101
54	KDR	0.66142578
55	DYRK2	0.65835259
56	ILK	0.65136273
57	CDC7	0.63291863
58	EIF2AK3	0.62638342
59	MAPKAPK5	0.61381580
60	CHEK2	0.61350927
61	DYRK1A	0.57164356
62	OXSR1	0.56302221
63	PLK2	0.53923968
64	BRD4	0.53493285
65	VRK1	0.48092233
66	PIK3CG	0.47704009
67	PRKCG	0.45886995
68	DAPK2	0.45326950
69	MUSK	0.45224666
70	CSNK1A1	0.42339278
71	TEC	0.41706339
72	BRSK2	0.41638542
73	EPHB1	0.40210468
74	RPS6KA5	0.39370598
75	ADRBK1	0.37878540
76	MINK1	0.37156167
77	PRKAA1	0.36620356
78	TNK2	0.36227170
79	MAP2K4	0.35151442
80	PRKACA	0.34075602
81	DAPK1	0.33383514
82	CSNK1D	0.32986705
83	NEK6	0.32677512
84	PRKCZ	0.32294851
85	ATM	0.30491215
86	ATR	0.29753968
87	CAMK2A	0.29164840
88	PKN1	0.28440683
89	PRKCI	0.28376811
90	RPS6KB1	0.26929701
91	NTRK3	0.26288124
92	ABL1	0.26273209
93	EIF2AK2	0.22517016
94	PRKCA	0.22509208
95	CDK5	0.22420777
96	MAP3K5	0.21751440
97	PRKACG	0.20895164
98	HCK	0.20843917
99	PRKACB	0.20657461
100	OBSCN	0.19351091

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.33131152
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.31705986
3	Phototransduction_Homo sapiens_hsa04744	3.04140647
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.29300433
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.27286675
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.27069454
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.26043658
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.21004590
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.14468401
10	Butanoate metabolism_Homo sapiens_hsa00650	2.11601913
11	Peroxisome_Homo sapiens_hsa04146	2.00497538
12	Propanoate metabolism_Homo sapiens_hsa00640	1.88522338
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88082901
14	Homologous recombination_Homo sapiens_hsa03440	1.82748336
15	Olfactory transduction_Homo sapiens_hsa04740	1.75812584
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.75754966
17	Taste transduction_Homo sapiens_hsa04742	1.72568292
18	Nicotine addiction_Homo sapiens_hsa05033	1.69188596
19	Arginine biosynthesis_Homo sapiens_hsa00220	1.68241116
20	Regulation of autophagy_Homo sapiens_hsa04140	1.63880568
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.63485667
22	Base excision repair_Homo sapiens_hsa03410	1.56778777
23	Fatty acid elongation_Homo sapiens_hsa00062	1.51424450
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48415296
25	RNA polymerase_Homo sapiens_hsa03020	1.46726271
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.43854401
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43146123
28	Caffeine metabolism_Homo sapiens_hsa00232	1.40351412
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37119151
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31543397
31	One carbon pool by folate_Homo sapiens_hsa00670	1.29941427
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.28286677
33	Protein export_Homo sapiens_hsa03060	1.25465227
34	Lysine degradation_Homo sapiens_hsa00310	1.21449255
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20690625
36	Basal transcription factors_Homo sapiens_hsa03022	1.20568506
37	RNA degradation_Homo sapiens_hsa03018	1.19106770
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14093197
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.13530305
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06055038
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.05215801
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.03482867
43	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03214133
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02513428
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01234485
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.99831067
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.98942923
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.96510518
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.95781817
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95449720
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94691343
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.92499238
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90901615
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89668998
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87844987
56	Sphingolipid metabolism_Homo sapiens_hsa00600	0.87524422
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87211003
58	Oxidative phosphorylation_Homo sapiens_hsa00190	0.86346552
59	Metabolic pathways_Homo sapiens_hsa01100	0.86160773
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86125847
61	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83881837
62	ABC transporters_Homo sapiens_hsa02010	0.83555493
63	Purine metabolism_Homo sapiens_hsa00230	0.81534834
64	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.81055178
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.79326932
66	RNA transport_Homo sapiens_hsa03013	0.78234514
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.78026451
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77463445
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.76073352
70	Retinol metabolism_Homo sapiens_hsa00830	0.75316011
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73857329
72	Parkinsons disease_Homo sapiens_hsa05012	0.73723902
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.73552039
74	Salivary secretion_Homo sapiens_hsa04970	0.65971996
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61067174
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.59203062
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58337999
78	Circadian entrainment_Homo sapiens_hsa04713	0.58301048
79	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.57694056
80	Proteasome_Homo sapiens_hsa03050	0.56705737
81	Carbon metabolism_Homo sapiens_hsa01200	0.56076617
82	GABAergic synapse_Homo sapiens_hsa04727	0.54878808
83	Sulfur metabolism_Homo sapiens_hsa00920	0.53226803
84	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.52745340
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49768880
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49008400
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47858637
88	Huntingtons disease_Homo sapiens_hsa05016	0.47635617
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.45676934
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45327855
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.43414748
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42705596
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.42684154
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.42630724
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.39970858
96	Morphine addiction_Homo sapiens_hsa05032	0.37626698
97	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.35608634
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33249501
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33177787
100	Long-term depression_Homo sapiens_hsa04730	0.32251666

GUSBP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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