ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.06417043
2	response to pheromone (GO:0019236)	4.84073180
3	L-fucose catabolic process (GO:0042355)	4.51355496
4	fucose catabolic process (GO:0019317)	4.51355496
5	L-fucose metabolic process (GO:0042354)	4.51355496
6	DNA deamination (GO:0045006)	4.09172970
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94567715
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94567715
9	NADH dehydrogenase complex assembly (GO:0010257)	3.94567715
10	protein complex biogenesis (GO:0070271)	3.89444442
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.85055275
12	negative regulation of mast cell activation (GO:0033004)	3.77726082
13	platelet dense granule organization (GO:0060155)	3.73441480
14	indolalkylamine metabolic process (GO:0006586)	3.69674018
15	negative regulation of telomere maintenance (GO:0032205)	3.66744819
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.57236147
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.55516351
18	tryptophan metabolic process (GO:0006568)	3.44639973
19	indole-containing compound catabolic process (GO:0042436)	3.43927690
20	indolalkylamine catabolic process (GO:0046218)	3.43927690
21	tryptophan catabolic process (GO:0006569)	3.43927690
22	protein-cofactor linkage (GO:0018065)	3.39027388
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.34928272
24	regulation of cilium movement (GO:0003352)	3.33941115
25	piRNA metabolic process (GO:0034587)	3.26042066
26	epithelial cilium movement (GO:0003351)	3.19463749
27	protein polyglutamylation (GO:0018095)	3.18164766
28	kynurenine metabolic process (GO:0070189)	3.16853895
29	respiratory chain complex IV assembly (GO:0008535)	3.14819837
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.13787474
31	protein localization to cilium (GO:0061512)	3.05141523
32	rRNA catabolic process (GO:0016075)	3.04533279
33	protein K11-linked deubiquitination (GO:0035871)	3.04031041
34	axoneme assembly (GO:0035082)	3.02786977
35	cellular ketone body metabolic process (GO:0046950)	3.02455726
36	cilium morphogenesis (GO:0060271)	2.98592536
37	neural tube formation (GO:0001841)	2.96001352
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94450884
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94450884
40	detection of light stimulus involved in sensory perception (GO:0050962)	2.92623990
41	detection of light stimulus involved in visual perception (GO:0050908)	2.92623990
42	replication fork processing (GO:0031297)	2.88693190
43	indole-containing compound metabolic process (GO:0042430)	2.88312836
44	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.87178617
45	mannosylation (GO:0097502)	2.84585121
46	neuronal action potential (GO:0019228)	2.83976145
47	pyrimidine nucleobase catabolic process (GO:0006208)	2.82617872
48	ketone body metabolic process (GO:1902224)	2.81532448
49	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.79879291
50	cytochrome complex assembly (GO:0017004)	2.79622952
51	photoreceptor cell maintenance (GO:0045494)	2.79106084
52	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.78751030
53	ATP synthesis coupled proton transport (GO:0015986)	2.78751030
54	kidney morphogenesis (GO:0060993)	2.78398704
55	sulfation (GO:0051923)	2.78340636
56	somite development (GO:0061053)	2.77984438
57	nonmotile primary cilium assembly (GO:0035058)	2.74708033
58	retinal cone cell development (GO:0046549)	2.74436304
59	ubiquinone biosynthetic process (GO:0006744)	2.74043667
60	reciprocal DNA recombination (GO:0035825)	2.72724869
61	reciprocal meiotic recombination (GO:0007131)	2.72724869
62	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72265145
63	regulation of action potential (GO:0098900)	2.70720939
64	pseudouridine synthesis (GO:0001522)	2.70591813
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.69749273
66	GPI anchor metabolic process (GO:0006505)	2.69071507
67	recombinational repair (GO:0000725)	2.68694888
68	rhodopsin mediated signaling pathway (GO:0016056)	2.68388822
69	regulation of telomere maintenance (GO:0032204)	2.68085418
70	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.67951465
71	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.65341439
72	reflex (GO:0060004)	2.63604988
73	double-strand break repair via homologous recombination (GO:0000724)	2.63567963
74	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.62756131
75	ubiquinone metabolic process (GO:0006743)	2.61787309
76	cilium movement (GO:0003341)	2.61252731
77	cilium organization (GO:0044782)	2.59706380
78	peptidyl-histidine modification (GO:0018202)	2.58252010
79	cornea development in camera-type eye (GO:0061303)	2.57765966
80	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.55073723
81	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.53461504
82	cellular biogenic amine catabolic process (GO:0042402)	2.53425448
83	amine catabolic process (GO:0009310)	2.53425448
84	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52000671
85	gamma-aminobutyric acid transport (GO:0015812)	2.51639369
86	regulation of microtubule-based movement (GO:0060632)	2.50040555
87	cilium assembly (GO:0042384)	2.49977848
88	photoreceptor cell development (GO:0042461)	2.48358196
89	nucleobase catabolic process (GO:0046113)	2.47224673
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46091627
91	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.44179215
92	behavioral response to ethanol (GO:0048149)	2.44003789
93	S-adenosylmethionine metabolic process (GO:0046500)	2.43279090
94	male meiosis I (GO:0007141)	2.43066978
95	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.41208809
96	intraciliary transport (GO:0042073)	2.39783395
97	primary amino compound metabolic process (GO:1901160)	2.39231986
98	DNA methylation involved in gamete generation (GO:0043046)	2.38682244
99	regulation of gene silencing by RNA (GO:0060966)	2.38420693
100	regulation of gene silencing by miRNA (GO:0060964)	2.38420693

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.34870834
2	VDR_22108803_ChIP-Seq_LS180_Human	3.39389019
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.84841310
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.70791316
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56968367
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55691230
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.55103621
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36926200
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.34291834
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27370016
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21378322
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.17789360
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12794297
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11902176
15	EWS_26573619_Chip-Seq_HEK293_Human	2.11473997
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10681005
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.10065738
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06065722
19	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.02930305
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.99729276
21	FUS_26573619_Chip-Seq_HEK293_Human	1.92726384
22	P300_19829295_ChIP-Seq_ESCs_Human	1.87362610
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87264901
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83961738
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.79894645
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.76043009
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.73774230
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.73501816
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.66700659
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66151830
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.61767601
32	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.61737430
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.47858301
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.45663496
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.44446502
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44107420
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44107420
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.40897295
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40897295
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38623519
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38061360
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35035982
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35032952
44	AR_25329375_ChIP-Seq_VCAP_Human	1.33921673
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32071780
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31967749
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31967749
48	STAT3_23295773_ChIP-Seq_U87_Human	1.29999653
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29224230
50	TCF4_23295773_ChIP-Seq_U87_Human	1.27906193
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27692197
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27692197
53	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27646631
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27230612
55	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26945780
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26895722
57	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26390880
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25876391
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24406265
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23774327
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23427033
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22447125
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22205893
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22166031
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22129020
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20756811
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20554636
68	AR_20517297_ChIP-Seq_VCAP_Human	1.19702917
69	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18824205
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18219176
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17430261
72	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.17242769
73	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16763080
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15609848
75	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12993875
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11543596
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11454769
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11284116
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11271079
80	NCOR_22424771_ChIP-Seq_293T_Human	1.10796075
81	TCF4_22108803_ChIP-Seq_LS180_Human	1.10427435
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08921731
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.08787373
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08295535
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06742917
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05567634
87	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04092358
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.01724348
89	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01176493
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99573122
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99223639
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99189591
93	ERA_21632823_ChIP-Seq_H3396_Human	0.98682400
94	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.97526141
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96452203
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95847675
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95293292
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95076928
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94585707
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92666898

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.87487290
2	MP0002102_abnormal_ear_morphology	2.68679980
3	MP0006292_abnormal_olfactory_placode	2.68479059
4	MP0005551_abnormal_eye_electrophysiolog	2.52021023
5	MP0006072_abnormal_retinal_apoptosis	2.46673799
6	MP0003195_calcinosis	2.45979499
7	MP0003787_abnormal_imprinting	2.32452214
8	MP0001968_abnormal_touch/_nociception	2.23864254
9	MP0004147_increased_porphyrin_level	2.22578020
10	MP0008872_abnormal_physiological_respon	2.14828608
11	MP0003646_muscle_fatigue	2.09876604
12	MP0008875_abnormal_xenobiotic_pharmacok	2.07555095
13	MP0005646_abnormal_pituitary_gland	1.99789741
14	MP0005253_abnormal_eye_physiology	1.96111654
15	MP0002837_dystrophic_cardiac_calcinosis	1.92208726
16	MP0001986_abnormal_taste_sensitivity	1.90872326
17	MP0002876_abnormal_thyroid_physiology	1.89033848
18	MP0002638_abnormal_pupillary_reflex	1.87357138
19	MP0009046_muscle_twitch	1.85444082
20	MP0002736_abnormal_nociception_after	1.83898163
21	MP0004885_abnormal_endolymph	1.82397185
22	MP0002938_white_spotting	1.80753512
23	MP0004133_heterotaxia	1.76696729
24	MP0004142_abnormal_muscle_tone	1.76007722
25	MP0009745_abnormal_behavioral_response	1.73916368
26	MP0000372_irregular_coat_pigmentation	1.72657920
27	MP0005084_abnormal_gallbladder_morpholo	1.71580891
28	MP0001984_abnormal_olfaction	1.66683048
29	MP0000427_abnormal_hair_cycle	1.66608239
30	MP0005645_abnormal_hypothalamus_physiol	1.66279479
31	MP0002272_abnormal_nervous_system	1.60255951
32	MP0000631_abnormal_neuroendocrine_gland	1.58276422
33	MP0003880_abnormal_central_pattern	1.56661898
34	MP0001485_abnormal_pinna_reflex	1.56223156
35	MP0001529_abnormal_vocalization	1.56081549
36	MP0006276_abnormal_autonomic_nervous	1.51789964
37	MP0003011_delayed_dark_adaptation	1.50544635
38	MP0002653_abnormal_ependyma_morphology	1.49645475
39	MP0004742_abnormal_vestibular_system	1.41164724
40	MP0008058_abnormal_DNA_repair	1.40542132
41	MP0001501_abnormal_sleep_pattern	1.35215543
42	MP0003136_yellow_coat_color	1.34159968
43	MP0001486_abnormal_startle_reflex	1.33648062
44	MP0002822_catalepsy	1.30500990
45	MP0010386_abnormal_urinary_bladder	1.30444990
46	MP0002733_abnormal_thermal_nociception	1.28034177
47	MP0002163_abnormal_gland_morphology	1.25506990
48	MP0004043_abnormal_pH_regulation	1.24771032
49	MP0002572_abnormal_emotion/affect_behav	1.21853863
50	MP0002735_abnormal_chemical_nociception	1.20718628
51	MP0002557_abnormal_social/conspecific_i	1.19979006
52	MP0001905_abnormal_dopamine_level	1.18405603
53	MP0002064_seizures	1.16769966
54	MP0001970_abnormal_pain_threshold	1.14681116
55	MP0002234_abnormal_pharynx_morphology	1.13424316
56	MP0000569_abnormal_digit_pigmentation	1.12441260
57	MP0008789_abnormal_olfactory_epithelium	1.12330035
58	MP0001764_abnormal_homeostasis	1.10128183
59	MP0005195_abnormal_posterior_eye	1.08891247
60	MP0005389_reproductive_system_phenotype	1.07193283
61	MP0002138_abnormal_hepatobiliary_system	1.07148138
62	MP0003718_maternal_effect	1.03368748
63	MP0005075_abnormal_melanosome_morpholog	1.01963683
64	MP0002928_abnormal_bile_duct	1.01091330
65	MP0004924_abnormal_behavior	1.00969389
66	MP0005386_behavior/neurological_phenoty	1.00969389
67	MP0002067_abnormal_sensory_capabilities	1.00452395
68	MP0002160_abnormal_reproductive_system	1.00160201
69	MP0001919_abnormal_reproductive_system	0.99619423
70	MP0003283_abnormal_digestive_organ	0.96200748
71	MP0002095_abnormal_skin_pigmentation	0.96117087
72	MP0005379_endocrine/exocrine_gland_phen	0.95411286
73	MP0003121_genomic_imprinting	0.94457128
74	MP0003122_maternal_imprinting	0.93886327
75	MP0002063_abnormal_learning/memory/cond	0.89809171
76	MP0002752_abnormal_somatic_nervous	0.88457280
77	MP0003635_abnormal_synaptic_transmissio	0.87782205
78	MP0002751_abnormal_autonomic_nervous	0.87566004
79	MP0002734_abnormal_mechanical_nocicepti	0.86490358
80	MP0008775_abnormal_heart_ventricle	0.85951394
81	MP0000383_abnormal_hair_follicle	0.84617332
82	MP0001324_abnormal_eye_pigmentation	0.84502130
83	MP0003698_abnormal_male_reproductive	0.84342133
84	MP0001293_anophthalmia	0.84294431
85	MP0004145_abnormal_muscle_electrophysio	0.84145020
86	MP0002277_abnormal_respiratory_mucosa	0.83688479
87	MP0005377_hearing/vestibular/ear_phenot	0.83583391
88	MP0003878_abnormal_ear_physiology	0.83583391
89	MP0000026_abnormal_inner_ear	0.83160251
90	MP0005391_vision/eye_phenotype	0.82054965
91	MP0005671_abnormal_response_to	0.80991633
92	MP0005410_abnormal_fertilization	0.80939275
93	MP0001929_abnormal_gametogenesis	0.80685172
94	MP0001963_abnormal_hearing_physiology	0.79775024
95	MP0000230_abnormal_systemic_arterial	0.79478261
96	MP0005085_abnormal_gallbladder_physiolo	0.79026090
97	MP0006036_abnormal_mitochondrial_physio	0.78059333
98	MP0005174_abnormal_tail_pigmentation	0.76899921
99	MP0004215_abnormal_myocardial_fiber	0.76767482
100	MP0001502_abnormal_circadian_rhythm	0.76736861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.32258277
2	Molar tooth sign on MRI (HP:0002419)	4.13120646
3	Abnormality of midbrain morphology (HP:0002418)	4.13120646
4	Pancreatic fibrosis (HP:0100732)	3.89658880
5	True hermaphroditism (HP:0010459)	3.87187788
6	Nephronophthisis (HP:0000090)	3.85422498
7	Congenital stationary night blindness (HP:0007642)	3.70208954
8	Type II lissencephaly (HP:0007260)	3.34162151
9	Abnormality of the renal medulla (HP:0100957)	3.28279388
10	Abnormality of the renal cortex (HP:0011035)	3.27153902
11	Medial flaring of the eyebrow (HP:0010747)	3.10708079
12	Attenuation of retinal blood vessels (HP:0007843)	3.09008473
13	Acute necrotizing encephalopathy (HP:0006965)	2.91267236
14	Abolished electroretinogram (ERG) (HP:0000550)	2.84848127
15	Chronic hepatic failure (HP:0100626)	2.77785620
16	Cystic liver disease (HP:0006706)	2.70746038
17	Large for gestational age (HP:0001520)	2.69202961
18	Hyperventilation (HP:0002883)	2.69011307
19	Pendular nystagmus (HP:0012043)	2.68418896
20	Increased CSF lactate (HP:0002490)	2.68173573
21	Mitochondrial inheritance (HP:0001427)	2.67494194
22	Acute encephalopathy (HP:0006846)	2.56692887
23	Progressive macrocephaly (HP:0004481)	2.53639118
24	Tubular atrophy (HP:0000092)	2.52880909
25	Gait imbalance (HP:0002141)	2.52549457
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51510920
27	Renal cortical cysts (HP:0000803)	2.49022507
28	Hepatocellular necrosis (HP:0001404)	2.45493011
29	Abnormal drinking behavior (HP:0030082)	2.43657189
30	Polydipsia (HP:0001959)	2.43657189
31	Abnormality of alanine metabolism (HP:0010916)	2.42765795
32	Hyperalaninemia (HP:0003348)	2.42765795
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.42765795
34	Hepatic necrosis (HP:0002605)	2.41099389
35	Congenital primary aphakia (HP:0007707)	2.40739245
36	Increased corneal curvature (HP:0100692)	2.36149619
37	Keratoconus (HP:0000563)	2.36149619
38	Cerebellar dysplasia (HP:0007033)	2.33475111
39	Lissencephaly (HP:0001339)	2.33364074
40	Optic disc pallor (HP:0000543)	2.33027057
41	Decreased central vision (HP:0007663)	2.32955415
42	Sclerocornea (HP:0000647)	2.32732006
43	Nephrogenic diabetes insipidus (HP:0009806)	2.31722462
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.29016644
45	Stomach cancer (HP:0012126)	2.25560128
46	Inability to walk (HP:0002540)	2.24857480
47	3-Methylglutaconic aciduria (HP:0003535)	2.22938418
48	Methylmalonic acidemia (HP:0002912)	2.18965314
49	Progressive inability to walk (HP:0002505)	2.15955651
50	Abnormal biliary tract physiology (HP:0012439)	2.15468342
51	Bile duct proliferation (HP:0001408)	2.15468342
52	Congenital hepatic fibrosis (HP:0002612)	2.15090561
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12907786
54	Hypothermia (HP:0002045)	2.12687266
55	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10984286
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08180851
57	Polyuria (HP:0000103)	2.06297222
58	Retinal dysplasia (HP:0007973)	2.04329217
59	Gaze-evoked nystagmus (HP:0000640)	2.03413741
60	Hyperglycinuria (HP:0003108)	2.02865458
61	Abnormality of the labia minora (HP:0012880)	2.02745934
62	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99841063
63	Postaxial foot polydactyly (HP:0001830)	1.98897771
64	Hyperglycinemia (HP:0002154)	1.98822633
65	Abnormal number of erythroid precursors (HP:0012131)	1.98533534
66	Abnormality of the pons (HP:0007361)	1.98289972
67	Congenital, generalized hypertrichosis (HP:0004540)	1.98019658
68	Furrowed tongue (HP:0000221)	1.97988712
69	Progressive cerebellar ataxia (HP:0002073)	1.95206698
70	Increased serum lactate (HP:0002151)	1.93959803
71	Genital tract atresia (HP:0001827)	1.93342142
72	Methylmalonic aciduria (HP:0012120)	1.92301702
73	Genetic anticipation (HP:0003743)	1.92120005
74	Colon cancer (HP:0003003)	1.89754698
75	Optic nerve hypoplasia (HP:0000609)	1.89557078
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89155127
77	Abnormality of DNA repair (HP:0003254)	1.88619188
78	Broad-based gait (HP:0002136)	1.88376954
79	Abnormality of the renal collecting system (HP:0004742)	1.88062271
80	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87713637
81	Male pseudohermaphroditism (HP:0000037)	1.87679945
82	Concave nail (HP:0001598)	1.85202394
83	Anencephaly (HP:0002323)	1.85094025
84	Duplicated collecting system (HP:0000081)	1.84517486
85	Vaginal atresia (HP:0000148)	1.84448899
86	Disproportionate short-trunk short stature (HP:0003521)	1.83960189
87	Patellar aplasia (HP:0006443)	1.83072722
88	Abnormality of the ileum (HP:0001549)	1.81720033
89	Bony spicule pigmentary retinopathy (HP:0007737)	1.80203254
90	Hypoplasia of the pons (HP:0012110)	1.78905946
91	Pachygyria (HP:0001302)	1.78589912
92	Chorioretinal atrophy (HP:0000533)	1.76654126
93	Lipid accumulation in hepatocytes (HP:0006561)	1.75589669
94	Abnormality of serine family amino acid metabolism (HP:0010894)	1.75545786
95	Abnormality of glycine metabolism (HP:0010895)	1.75545786
96	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75267899
97	Increased hepatocellular lipid droplets (HP:0006565)	1.73887481
98	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71491592
99	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71095096
100	Absent/shortened dynein arms (HP:0200106)	1.71095096

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.44827808
2	MAP4K2	3.60063387
3	ADRBK2	3.29977350
4	ZAK	2.93567415
5	TAOK3	2.79465884
6	NUAK1	2.60407882
7	GRK1	2.59141545
8	WNK3	2.53620900
9	BMPR1B	2.48711913
10	TLK1	2.29695022
11	ACVR1B	2.04352193
12	CASK	2.01014003
13	INSRR	1.78281896
14	TXK	1.76659891
15	WNK4	1.73283616
16	PINK1	1.70757208
17	MAPK13	1.63032074
18	MAP3K4	1.61821460
19	DYRK2	1.58530514
20	OXSR1	1.41398750
21	CAMKK2	1.30814984
22	DAPK2	1.25761929
23	VRK2	1.23678063
24	ADRBK1	1.21373624
25	PAK3	1.18602563
26	TIE1	1.17459010
27	VRK1	1.17035895
28	BCKDK	1.12698678
29	MAP2K7	1.12332743
30	MKNK2	1.04419487
31	MARK1	1.02521469
32	MUSK	0.99953970
33	STK39	0.97357063
34	PHKG1	0.95302963
35	PHKG2	0.95302963
36	CSNK1G3	0.94369605
37	CSNK1G1	0.92992903
38	CSNK1G2	0.92053827
39	TGFBR1	0.91269660
40	MAP3K12	0.89893852
41	PRKCG	0.89301201
42	EPHA3	0.88190210
43	PRKCE	0.85905854
44	IKBKB	0.84468094
45	FLT3	0.82811404
46	PASK	0.81317599
47	LIMK1	0.81167026
48	MAPKAPK3	0.80295732
49	TRIM28	0.78093566
50	KIT	0.77922493
51	BCR	0.77670853
52	NTRK3	0.71398909
53	BRSK2	0.70667759
54	TNIK	0.69370256
55	EPHA4	0.68885697
56	IRAK1	0.66364386
57	RPS6KA5	0.66293796
58	PTK2B	0.65065207
59	CSNK1A1L	0.65060616
60	SIK2	0.64631621
61	STK38L	0.63773089
62	TEC	0.63634204
63	PRKCQ	0.63524568
64	MAP2K6	0.63396715
65	PLK2	0.62509472
66	STK3	0.60892581
67	TAF1	0.60807392
68	PLK3	0.60398681
69	PIK3CA	0.60282977
70	TNK2	0.58132525
71	GRK5	0.56725249
72	MKNK1	0.55127272
73	ATR	0.54826594
74	NEK2	0.51842899
75	ITK	0.49996111
76	MAP4K1	0.49625458
77	NTRK2	0.47786725
78	CAMK2A	0.47628635
79	MST4	0.47035308
80	NLK	0.45673470
81	PRKACA	0.45447511
82	PLK4	0.45043595
83	CAMK1	0.44657581
84	CSNK1A1	0.44431933
85	STK11	0.43909338
86	CAMKK1	0.43639216
87	PKN1	0.42068048
88	TSSK6	0.40761012
89	CHUK	0.39263936
90	PRKCI	0.37744993
91	PLK1	0.37623121
92	CDK8	0.37053534
93	CHEK2	0.36536755
94	NME1	0.36008948
95	MAPK15	0.35564775
96	ERBB3	0.35414197
97	CSNK1D	0.33919213
98	MAP2K2	0.33298826
99	PRKCA	0.33220383
100	EIF2AK3	0.32027609

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.95129245
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74435651
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60802900
4	Protein export_Homo sapiens_hsa03060	2.57324273
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.47240233
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46513971
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36095404
8	Butanoate metabolism_Homo sapiens_hsa00650	2.32730440
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30585156
10	Parkinsons disease_Homo sapiens_hsa05012	2.21335741
11	RNA polymerase_Homo sapiens_hsa03020	2.13824208
12	Homologous recombination_Homo sapiens_hsa03440	2.13361057
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08393082
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.03106905
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98747590
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.94241786
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.91274579
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.82655568
19	Basal transcription factors_Homo sapiens_hsa03022	1.78364618
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76419084
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73599224
22	Nicotine addiction_Homo sapiens_hsa05033	1.70875162
23	One carbon pool by folate_Homo sapiens_hsa00670	1.70864604
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.63703120
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.60095988
26	Caffeine metabolism_Homo sapiens_hsa00232	1.51474527
27	RNA degradation_Homo sapiens_hsa03018	1.45833420
28	Huntingtons disease_Homo sapiens_hsa05016	1.44302750
29	Alzheimers disease_Homo sapiens_hsa05010	1.31877220
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30071544
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24047123
32	Propanoate metabolism_Homo sapiens_hsa00640	1.21494780
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20490330
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19722300
35	Peroxisome_Homo sapiens_hsa04146	1.19268411
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18813199
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.14584486
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12645254
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12225916
40	Regulation of autophagy_Homo sapiens_hsa04140	1.11840224
41	Taste transduction_Homo sapiens_hsa04742	1.10664465
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.07992683
43	Ribosome_Homo sapiens_hsa03010	1.06424317
44	Olfactory transduction_Homo sapiens_hsa04740	1.04522278
45	Morphine addiction_Homo sapiens_hsa05032	1.03311080
46	Proteasome_Homo sapiens_hsa03050	1.01558563
47	Sulfur metabolism_Homo sapiens_hsa00920	0.99638158
48	Purine metabolism_Homo sapiens_hsa00230	0.98250956
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.96963251
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.95519013
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91459395
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91169909
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90214695
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86556477
55	Insulin secretion_Homo sapiens_hsa04911	0.84384717
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.83569556
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.83527135
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81808319
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80373421
60	Serotonergic synapse_Homo sapiens_hsa04726	0.74194098
61	Retinol metabolism_Homo sapiens_hsa00830	0.72224716
62	Circadian entrainment_Homo sapiens_hsa04713	0.71759710
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70700368
64	Metabolic pathways_Homo sapiens_hsa01100	0.70368566
65	GABAergic synapse_Homo sapiens_hsa04727	0.70257413
66	ABC transporters_Homo sapiens_hsa02010	0.69024076
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68330207
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67935389
69	Base excision repair_Homo sapiens_hsa03410	0.67166871
70	Circadian rhythm_Homo sapiens_hsa04710	0.66266399
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65308580
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.64704495
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63567671
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62180144
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.61498786
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60510162
77	Asthma_Homo sapiens_hsa05310	0.59407645
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56577870
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.56343279
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54006454
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53282559
82	Mismatch repair_Homo sapiens_hsa03430	0.51788656
83	Mineral absorption_Homo sapiens_hsa04978	0.50624370
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48781358
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48405855
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47610733
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46884568
88	Fatty acid elongation_Homo sapiens_hsa00062	0.45964759
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43824353
90	Salivary secretion_Homo sapiens_hsa04970	0.42519420
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41404140
92	Sulfur relay system_Homo sapiens_hsa04122	0.40340569
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40062799
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38519708
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.37218680
96	Fatty acid degradation_Homo sapiens_hsa00071	0.36700492
97	Allograft rejection_Homo sapiens_hsa05330	0.36163215
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35623239
99	Folate biosynthesis_Homo sapiens_hsa00790	0.35438690
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34573744

GUSBP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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