GUSBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)7.60618861
2positive regulation of catecholamine secretion (GO:0033605)7.33424583
3sperm motility (GO:0030317)7.16260454
4arginine catabolic process (GO:0006527)7.14636103
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.82201839
6positive regulation of cell size (GO:0045793)6.63040625
7diaphragm development (GO:0060539)6.17033719
8spermatid development (GO:0007286)6.07367706
9fusion of sperm to egg plasma membrane (GO:0007342)5.96414731
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.81005560
11protein targeting to Golgi (GO:0000042)5.80700802
12axonemal dynein complex assembly (GO:0070286)5.76981845
13epithelial cilium movement (GO:0003351)5.55520491
14arginine metabolic process (GO:0006525)5.55007235
15skeletal muscle organ development (GO:0060538)5.54619196
16establishment of protein localization to Golgi (GO:0072600)5.49194671
17oogenesis (GO:0048477)5.45189778
18positive regulation of guanylate cyclase activity (GO:0031284)5.38085527
19regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.28640201
20retrograde transport, vesicle recycling within Golgi (GO:0000301)5.26318459
21pyrimidine nucleoside salvage (GO:0043097)5.15573165
22pyrimidine-containing compound salvage (GO:0008655)5.15573165
23piRNA metabolic process (GO:0034587)5.11669742
24male meiosis (GO:0007140)5.01975679
25multicellular organism reproduction (GO:0032504)4.97452152
26positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.94710152
27regulation of oxidative stress-induced neuron death (GO:1903203)4.89294366
28regulation of guanylate cyclase activity (GO:0031282)4.88704817
29binding of sperm to zona pellucida (GO:0007339)4.82031677
30negative regulation of neurotransmitter transport (GO:0051589)4.77039465
31synapsis (GO:0007129)4.76060524
32plasma membrane fusion (GO:0045026)4.74082752
33exogenous drug catabolic process (GO:0042738)4.68219137
34negative regulation of calcium ion transport into cytosol (GO:0010523)4.59927880
35cilium or flagellum-dependent cell motility (GO:0001539)4.51494787
36sperm-egg recognition (GO:0035036)4.51246008
37protein localization to Golgi apparatus (GO:0034067)4.46551134
38response to lipoprotein particle (GO:0055094)4.45424610
39regulation of cilium movement (GO:0003352)4.44598384
40cilium movement (GO:0003341)4.42326055
41motile cilium assembly (GO:0044458)4.37277434
42regulation of phosphoprotein phosphatase activity (GO:0043666)4.34355357
43DNA methylation involved in gamete generation (GO:0043046)4.30254904
44negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.29965605
45negative regulation of potassium ion transport (GO:0043267)4.26449630
46negative regulation of vascular permeability (GO:0043116)4.24457957
47microtubule depolymerization (GO:0007019)4.20141609
48germ cell development (GO:0007281)4.19606782
49regulation of neurotransmitter uptake (GO:0051580)4.14725826
50regulation of oxidative phosphorylation (GO:0002082)4.14392129
51cellular protein complex localization (GO:0034629)4.09212665
52negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.08060639
53chromatin silencing (GO:0006342)4.06385970
54reproduction (GO:0000003)4.03202915
55pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.97954390
56UMP biosynthetic process (GO:0006222)3.97954390
57pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.97954390
58UMP metabolic process (GO:0046049)3.97954390
59regulation of meiosis I (GO:0060631)3.91579968
60protein complex localization (GO:0031503)3.89089501
61single fertilization (GO:0007338)3.85625871
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.79875827
63regulation of cilium assembly (GO:1902017)3.76259799
64regulation of synaptic vesicle transport (GO:1902803)3.75600360
65male gamete generation (GO:0048232)3.73768925
66spermatogenesis (GO:0007283)3.73307416
67regulation of dopamine secretion (GO:0014059)3.72852499
68centriole assembly (GO:0098534)3.72697029
69glutamine family amino acid catabolic process (GO:0009065)3.72693715
70positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.71916834
71cell-cell recognition (GO:0009988)3.71881138
72negative regulation of granulocyte differentiation (GO:0030853)3.71346897
73positive regulation of receptor biosynthetic process (GO:0010870)3.69126383
74drug catabolic process (GO:0042737)3.68249339
75calcium ion-dependent exocytosis (GO:0017156)3.67715945
76spermatid nucleus differentiation (GO:0007289)3.65710160
77nitric oxide mediated signal transduction (GO:0007263)3.61148055
78gamete generation (GO:0007276)3.57149448
79protein polyglutamylation (GO:0018095)3.51793294
80positive regulation of circadian rhythm (GO:0042753)3.50495668
81regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.46013291
82positive regulation of amine transport (GO:0051954)3.45133273
83regulation of stem cell maintenance (GO:2000036)3.40453586
84mitochondrion degradation (GO:0000422)3.37588882
85inactivation of MAPK activity (GO:0000188)3.37384646
86positive regulation of Rab GTPase activity (GO:0032851)3.37323415
87regulation of Rab GTPase activity (GO:0032313)3.37323415
88cellular process involved in reproduction in multicellular organism (GO:0022412)3.35300635
89nucleoside salvage (GO:0043174)3.34944764
90positive regulation of cGMP biosynthetic process (GO:0030828)3.34022511
91female gamete generation (GO:0007292)3.32460245
92positive regulation of signal transduction by p53 class mediator (GO:1901798)3.32144960
93protein heterotrimerization (GO:0070208)3.31860148
94coenzyme catabolic process (GO:0009109)3.31197387
95nucleotide salvage (GO:0043173)3.30955968
96microtubule polymerization or depolymerization (GO:0031109)3.30393376
97nitric oxide biosynthetic process (GO:0006809)3.28870745
98lateral sprouting from an epithelium (GO:0060601)3.25748313
99histone H3-K4 methylation (GO:0051568)3.23731400
100centriole replication (GO:0007099)3.22051216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.74952808
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.11510375
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04258946
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.87788344
5ZNF274_21170338_ChIP-Seq_K562_Hela2.78828141
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.72282507
7IGF1R_20145208_ChIP-Seq_DFB_Human2.65794401
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65362344
9FUS_26573619_Chip-Seq_HEK293_Human2.44934779
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.21391713
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11121555
12CBP_20019798_ChIP-Seq_JUKART_Human1.96468730
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.96468730
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.90060598
15ARNT_22903824_ChIP-Seq_MCF-7_Human1.87333503
16POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79277364
17TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79277364
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76823545
19SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76335368
20AHR_22903824_ChIP-Seq_MCF-7_Human1.72507410
21AR_21572438_ChIP-Seq_LNCaP_Human1.71320230
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69818248
23ER_23166858_ChIP-Seq_MCF-7_Human1.68467547
24P53_22127205_ChIP-Seq_FIBROBLAST_Human1.66765603
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61857868
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.59354863
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.58748224
28P300_19829295_ChIP-Seq_ESCs_Human1.58229842
29SMAD3_21741376_ChIP-Seq_ESCs_Human1.56955831
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53908759
31SMC4_20622854_ChIP-Seq_HELA_Human1.53252084
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52836610
33AR_25329375_ChIP-Seq_VCAP_Human1.49909763
34ERA_21632823_ChIP-Seq_H3396_Human1.49789104
35RAC3_21632823_ChIP-Seq_H3396_Human1.49022485
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46069118
37TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46038613
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.40627793
39RUNX_20019798_ChIP-Seq_JUKART_Human1.38959449
40DROSHA_22980978_ChIP-Seq_HELA_Human1.38244352
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.38150885
42NANOG_20526341_ChIP-Seq_ESCs_Human1.35368125
43SMAD4_21799915_ChIP-Seq_A2780_Human1.34521639
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33102029
45ERG_20517297_ChIP-Seq_VCAP_Human1.32676901
46OCT1_27270436_Chip-Seq_PROSTATE_Human1.32326807
47STAT3_23295773_ChIP-Seq_U87_Human1.31228345
48OCT4_20526341_ChIP-Seq_ESCs_Human1.29497307
49NANOG_19829295_ChIP-Seq_ESCs_Human1.29223442
50SOX2_19829295_ChIP-Seq_ESCs_Human1.29223442
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29081737
52TBL1_22424771_ChIP-Seq_293T_Human1.24777675
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23417570
54VDR_22108803_ChIP-Seq_LS180_Human1.21597338
55CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20246205
56RUNX2_22187159_ChIP-Seq_PCA_Human1.19547603
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18888932
58MYC_19829295_ChIP-Seq_ESCs_Human1.18487312
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18189144
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16778820
61TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.16304761
62TP53_18474530_ChIP-ChIP_U2OS_Human1.16274676
63HOXB7_26014856_ChIP-Seq_BT474_Human1.15881454
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15367054
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14332186
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.12299635
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.09956696
68TCF4_22108803_ChIP-Seq_LS180_Human1.08760414
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08582039
70ETV1_20927104_ChIP-Seq_GIST48_Human1.06916421
71GBX2_23144817_ChIP-Seq_PC3_Human1.06225539
72GATA1_22025678_ChIP-Seq_K562_Human1.06135068
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.04846390
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04146529
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03856137
76FOXH1_21741376_ChIP-Seq_ESCs_Human1.03352001
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02406634
78TCF4_23295773_ChIP-Seq_U87_Human1.00621750
79PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00125389
80SMAD4_21741376_ChIP-Seq_HESCs_Human0.99876017
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98603562
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98194095
83CJUN_26792858_Chip-Seq_BT549_Human0.97599611
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97390204
85PHF8_20622853_ChIP-Seq_HELA_Human0.97013033
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96924797
87TAF2_19829295_ChIP-Seq_ESCs_Human0.96355903
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96317080
89RBPJ_21746931_ChIP-Seq_IB4_Human0.96206902
90NFYB_21822215_ChIP-Seq_K562_Human0.95720141
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95432247
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95019248
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95011569
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.94616309
95TAF15_26573619_Chip-Seq_HEK293_Human0.93856836
96SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92356441
97RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91915279
98SMAD4_21741376_ChIP-Seq_ESCs_Human0.91780082
99CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91411618
100NFYA_21822215_ChIP-Seq_K562_Human0.91292628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.09592915
2MP0000566_synostosis5.99054023
3MP0005410_abnormal_fertilization5.57933393
4MP0002234_abnormal_pharynx_morphology4.34533947
5MP0010368_abnormal_lymphatic_system4.13080096
6MP0004233_abnormal_muscle_weight3.72822563
7MP0003045_fibrosis3.39335422
8MP0005645_abnormal_hypothalamus_physiol3.29554773
9MP0005167_abnormal_blood-brain_barrier3.26777235
10MP0004043_abnormal_pH_regulation3.26217195
11MP0004858_abnormal_nervous_system2.65080434
12MP0003718_maternal_effect2.50237785
13MP0003698_abnormal_male_reproductive2.40162991
14MP0009053_abnormal_anal_canal2.22151244
15MP0004084_abnormal_cardiac_muscle2.19749759
16MP0003315_abnormal_perineum_morphology2.10377612
17MP0001929_abnormal_gametogenesis2.10014186
18MP0005670_abnormal_white_adipose2.00064943
19MP0001501_abnormal_sleep_pattern1.88408986
20MP0001664_abnormal_digestion1.83663788
21MP0005499_abnormal_olfactory_system1.73373735
22MP0005394_taste/olfaction_phenotype1.73373735
23MP0008995_early_reproductive_senescence1.66066360
24MP0002837_dystrophic_cardiac_calcinosis1.62055563
25MP0003283_abnormal_digestive_organ1.57016484
26MP0008004_abnormal_stomach_pH1.55500176
27MP0003136_yellow_coat_color1.50322927
28MP0001919_abnormal_reproductive_system1.44004200
29MP0002210_abnormal_sex_determination1.42878682
30MP0002233_abnormal_nose_morphology1.42392426
31MP0000467_abnormal_esophagus_morphology1.40236131
32MP0005423_abnormal_somatic_nervous1.38037046
33MP0005377_hearing/vestibular/ear_phenot1.37812105
34MP0003878_abnormal_ear_physiology1.37812105
35MP0006082_CNS_inflammation1.37098038
36MP0002161_abnormal_fertility/fecundity1.32926227
37MP0001984_abnormal_olfaction1.32222086
38MP0008789_abnormal_olfactory_epithelium1.29227130
39MP0008877_abnormal_DNA_methylation1.26408636
40MP0002127_abnormal_cardiovascular_syste1.23635782
41MP0000537_abnormal_urethra_morphology1.21517996
42MP0008872_abnormal_physiological_respon1.20422795
43MP0005389_reproductive_system_phenotype1.14211059
44MP0004036_abnormal_muscle_relaxation1.11116371
45MP0001145_abnormal_male_reproductive1.10319086
46MP0001764_abnormal_homeostasis1.08297999
47MP0003879_abnormal_hair_cell1.08262450
48MP0000653_abnormal_sex_gland1.06576899
49MP0002168_other_aberrant_phenotype1.04114744
50MP0010307_abnormal_tumor_latency1.02951964
51MP0005395_other_phenotype1.02099728
52MP0000470_abnormal_stomach_morphology1.01261006
53MP0000631_abnormal_neuroendocrine_gland1.00078430
54MP0008775_abnormal_heart_ventricle0.99179889
55MP0002132_abnormal_respiratory_system0.96415559
56MP0001879_abnormal_lymphatic_vessel0.92508730
57MP0008058_abnormal_DNA_repair0.89503301
58MP0000733_abnormal_muscle_development0.89451475
59MP0000955_abnormal_spinal_cord0.88602394
60MP0002160_abnormal_reproductive_system0.87887985
61MP0002009_preneoplasia0.86574578
62MP0005647_abnormal_sex_gland0.83628162
63MP0004484_altered_response_of0.83618000
64MP0005360_urolithiasis0.81131911
65MP0002272_abnormal_nervous_system0.80348262
66MP0009745_abnormal_behavioral_response0.77472395
67MP0004133_heterotaxia0.75567800
68MP0003937_abnormal_limbs/digits/tail_de0.75228687
69MP0003119_abnormal_digestive_system0.74395650
70MP0002109_abnormal_limb_morphology0.72603312
71MP0001486_abnormal_startle_reflex0.72469986
72MP0005171_absent_coat_pigmentation0.71819068
73MP0001440_abnormal_grooming_behavior0.70502229
74MP0004085_abnormal_heartbeat0.69223841
75MP0006138_congestive_heart_failure0.67316451
76MP0000538_abnormal_urinary_bladder0.66528188
77MP0000230_abnormal_systemic_arterial0.66074817
78MP0006072_abnormal_retinal_apoptosis0.64790311
79MP0003631_nervous_system_phenotype0.64351249
80MP0003633_abnormal_nervous_system0.62978726
81MP0004811_abnormal_neuron_physiology0.58727534
82MP0009764_decreased_sensitivity_to0.57024450
83MP0002572_abnormal_emotion/affect_behav0.56845241
84MP0000026_abnormal_inner_ear0.55855434
85MP0002116_abnormal_craniofacial_bone0.53887639
86MP0001756_abnormal_urination0.53862706
87MP0001905_abnormal_dopamine_level0.53859161
88MP0000383_abnormal_hair_follicle0.53733235
89MP0002184_abnormal_innervation0.53579189
90MP0003890_abnormal_embryonic-extraembry0.52035261
91MP0002735_abnormal_chemical_nociception0.51923714
92MP0002064_seizures0.51306078
93MP0000432_abnormal_head_morphology0.50086293
94MP0001970_abnormal_pain_threshold0.49791751
95MP0005253_abnormal_eye_physiology0.48901980
96MP0002063_abnormal_learning/memory/cond0.48736976
97MP0001485_abnormal_pinna_reflex0.47894440
98MP0005076_abnormal_cell_differentiation0.47399628
99MP0004883_abnormal_blood_vessel0.46969438
100MP0001119_abnormal_female_reproductive0.46782035

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.61014062
2Autoimmune thrombocytopenia (HP:0001973)6.60840385
3Sparse lateral eyebrow (HP:0005338)5.65905372
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.45993836
5Anal stenosis (HP:0002025)5.41871991
6Intestinal fistula (HP:0100819)5.20995799
7Abnormality of the fingertips (HP:0001211)5.02576039
8Depressed nasal tip (HP:0000437)4.98959456
9Ureteral stenosis (HP:0000071)4.71721768
10Resting tremor (HP:0002322)4.51047411
11Ureteral obstruction (HP:0006000)4.28788385
12Abnormal respiratory motile cilium physiology (HP:0012261)4.10638161
13Abnormal respiratory motile cilium morphology (HP:0005938)3.95145445
14Abnormal respiratory epithelium morphology (HP:0012253)3.95145445
15Short 5th finger (HP:0009237)3.91491157
16Ectopic kidney (HP:0000086)3.82579928
17Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.69343105
18Atonic seizures (HP:0010819)3.64675463
19Absent/shortened dynein arms (HP:0200106)3.52154179
20Dynein arm defect of respiratory motile cilia (HP:0012255)3.52154179
21Popliteal pterygium (HP:0009756)3.45867202
22Severe visual impairment (HP:0001141)3.18794318
23Preauricular pit (HP:0004467)3.15259027
24Periauricular skin pits (HP:0100277)3.15259027
25Chronic bronchitis (HP:0004469)3.10483810
26Abnormal ciliary motility (HP:0012262)3.08999793
27Lower limb hyperreflexia (HP:0002395)3.05378170
28Postural instability (HP:0002172)3.00245015
29Infertility (HP:0000789)2.95491981
30Self-mutilation (HP:0000742)2.85195223
31Abnormal drinking behavior (HP:0030082)2.83658640
32Polydipsia (HP:0001959)2.83658640
33Pancreatic cysts (HP:0001737)2.82276077
34Tubulointerstitial nephritis (HP:0001970)2.75202763
35Cerebellar dysplasia (HP:0007033)2.71281505
36Abnormal sex determination (HP:0012244)2.60724371
37Sex reversal (HP:0012245)2.60724371
38Rhinitis (HP:0012384)2.58915584
39Chronic hepatic failure (HP:0100626)2.51441792
40Potter facies (HP:0002009)2.50959914
41Facial shape deformation (HP:0011334)2.50959914
42Increased CSF protein (HP:0002922)2.43368882
43Hypoplasia of the uterus (HP:0000013)2.42819192
44Posterior subcapsular cataract (HP:0007787)2.40345566
45Absent thumb (HP:0009777)2.40022330
46Abnormality of cochlea (HP:0000375)2.38587936
47Recurrent otitis media (HP:0000403)2.35529571
48Tubulointerstitial abnormality (HP:0001969)2.33763508
49Ectropion (HP:0000656)2.33627365
50Amelogenesis imperfecta (HP:0000705)2.31452932
51Abnormality of the renal cortex (HP:0011035)2.31007982
52Type II lissencephaly (HP:0007260)2.30879556
53Generalized aminoaciduria (HP:0002909)2.30366127
54Congenital sensorineural hearing impairment (HP:0008527)2.26830243
55Tubular atrophy (HP:0000092)2.25900379
56Bronchiectasis (HP:0002110)2.23795761
57Thyroid-stimulating hormone excess (HP:0002925)2.23452660
58Non-midline cleft lip (HP:0100335)2.22400486
59Subcapsular cataract (HP:0000523)2.19264386
60Skin pits (HP:0100276)2.16734535
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13683221
62Vertebral hypoplasia (HP:0008417)2.13683221
63Neoplasm of the heart (HP:0100544)2.10115552
64Nasal polyposis (HP:0100582)2.09274890
65Fibular aplasia (HP:0002990)2.07135646
66Respiratory distress (HP:0002098)2.05871022
67Preaxial foot polydactyly (HP:0001841)2.05527850
68Gonadal dysgenesis (HP:0000133)2.01838212
69Aplasia/hypoplasia of the uterus (HP:0008684)1.96437935
70Abnormality of macular pigmentation (HP:0008002)1.96325431
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.94721993
72Polyuria (HP:0000103)1.92540335
73Long palpebral fissure (HP:0000637)1.91901969
74Facial cleft (HP:0002006)1.90439048
75Abnormality of the periventricular white matter (HP:0002518)1.89115499
76Pheochromocytoma (HP:0002666)1.89045153
77Tubulointerstitial fibrosis (HP:0005576)1.89000173
78Absent eyebrow (HP:0002223)1.88764829
79Morphological abnormality of the inner ear (HP:0011390)1.88389241
80Dialeptic seizures (HP:0011146)1.88022782
81Aplasia involving bones of the extremities (HP:0009825)1.88020407
82Aplasia involving bones of the upper limbs (HP:0009823)1.88020407
83Aplasia of the phalanges of the hand (HP:0009802)1.88020407
84Median cleft lip (HP:0000161)1.87380381
85Bony spicule pigmentary retinopathy (HP:0007737)1.87224262
86Urinary glycosaminoglycan excretion (HP:0003541)1.87047118
87Mucopolysacchariduria (HP:0008155)1.87047118
88Ependymoma (HP:0002888)1.86615773
89Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85583172
90Abnormal urine output (HP:0012590)1.82308642
91Wide intermamillary distance (HP:0006610)1.76599471
92Confusion (HP:0001289)1.76214867
93Renal dysplasia (HP:0000110)1.75189769
94Male pseudohermaphroditism (HP:0000037)1.72154801
95Concave nail (HP:0001598)1.71981845
96Hypoplastic labia majora (HP:0000059)1.71078247
97Anterior segment dysgenesis (HP:0007700)1.71051254
98Enlarged kidneys (HP:0000105)1.70519726
99Attenuation of retinal blood vessels (HP:0007843)1.68756187
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67934588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.98006359
2STK246.19939137
3STK394.21612244
4WNK44.20160724
5ZAK3.43939424
6CCNB13.41307754
7MAP3K23.07889469
8LATS12.60436170
9EEF2K2.52462812
10PLK42.39074788
11MAP3K32.35223526
12JAK32.00796890
13WNK11.90371397
14MARK31.84867315
15STK38L1.70972795
16ILK1.55275770
17MAPKAPK31.43266806
18CAMK11.43130629
19INSRR1.30725020
20LATS21.29412899
21CAMK41.25285547
22CAMK1G1.22700821
23TLK11.18210110
24PRKCQ1.16781345
25PNCK1.11650856
26BRD41.01635614
27PLK21.01242269
28PIK3CG0.98586176
29NTRK20.97903439
30STK380.97451269
31BMPR1B0.96953341
32CHEK20.90496149
33FRK0.89979858
34RPS6KL10.89805935
35RPS6KC10.89805935
36RPS6KA60.89340296
37RPS6KA50.88439258
38MAP4K20.86688744
39ACVR1B0.80789064
40TRPM70.73534481
41CDC70.68849212
42CSNK1A1L0.67430915
43DYRK30.66681210
44CAMK1D0.65243065
45MYLK0.65220002
46NEK20.63497434
47MAPKAPK50.62148672
48MAP2K70.61311145
49MAPK130.58882395
50MINK10.55185152
51CSNK1G30.54653976
52MUSK0.54259682
53RPS6KA20.51075567
54TNIK0.48558308
55CSNK1G20.48005846
56SRPK10.44788773
57PRKD30.44452838
58PDPK10.44173326
59MAPK150.43584714
60SGK2230.43323357
61SGK4940.43323357
62CDK30.42774354
63DAPK20.39874765
64CSNK1G10.37623120
65TIE10.35037961
66EGFR0.34147455
67MELK0.32795495
68PRKG20.30135918
69TRIM280.28830790
70GRK10.28530067
71PDK10.28298870
72PTK2B0.27971590
73MARK10.25065284
74RPS6KB10.24966971
75TTK0.24912971
76NEK60.24871997
77MAP3K40.24396510
78PRKAA20.24088976
79CDK90.23979891
80OBSCN0.23010205
81PRKG10.21103032
82SGK20.20654161
83TNK20.19935164
84ADRBK20.18279750
85PRKCZ0.18279022
86PRKCG0.17848279
87TGFBR10.17799104
88CSNK1A10.16482275
89RPS6KB20.16406471
90ERBB30.16342259
91PKN10.15893454
92MST1R0.15410049
93STK40.14786916
94PRKCE0.14431254
95CAMKK20.13917527
96ADRBK10.12590846
97HCK0.12539002
98DDR20.09920948
99CDK50.09816037
100PRKACA0.09659652

Predicted pathways (KEGG)

RankGene SetZ-score
1Arginine biosynthesis_Homo sapiens_hsa002205.95584009
2Nitrogen metabolism_Homo sapiens_hsa009103.39432499
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24451637
4Olfactory transduction_Homo sapiens_hsa047403.18947832
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.13798676
6Phototransduction_Homo sapiens_hsa047442.78811410
7Taste transduction_Homo sapiens_hsa047422.48613457
8Gap junction_Homo sapiens_hsa045402.27034673
9Dorso-ventral axis formation_Homo sapiens_hsa043202.26735971
10Butanoate metabolism_Homo sapiens_hsa006501.97679210
11AMPK signaling pathway_Homo sapiens_hsa041521.87163261
12Hedgehog signaling pathway_Homo sapiens_hsa043401.86939340
13Fatty acid biosynthesis_Homo sapiens_hsa000611.83768129
14Phagosome_Homo sapiens_hsa041451.81804698
15Lysine degradation_Homo sapiens_hsa003101.81417380
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.79023636
17Circadian entrainment_Homo sapiens_hsa047131.59630587
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57754141
19Alcoholism_Homo sapiens_hsa050341.47118395
20N-Glycan biosynthesis_Homo sapiens_hsa005101.46426214
21Fanconi anemia pathway_Homo sapiens_hsa034601.41779444
22Salivary secretion_Homo sapiens_hsa049701.36704014
23Arginine and proline metabolism_Homo sapiens_hsa003301.36044895
24Systemic lupus erythematosus_Homo sapiens_hsa053221.27992763
25TGF-beta signaling pathway_Homo sapiens_hsa043501.26162353
26Propanoate metabolism_Homo sapiens_hsa006401.25885381
27Nicotine addiction_Homo sapiens_hsa050331.21750110
28mRNA surveillance pathway_Homo sapiens_hsa030151.20499061
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16339871
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15747573
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.13961358
32Sphingolipid signaling pathway_Homo sapiens_hsa040711.12267993
33Calcium signaling pathway_Homo sapiens_hsa040201.08261249
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.06648834
35Phenylalanine metabolism_Homo sapiens_hsa003601.00788492
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99867943
37Dopaminergic synapse_Homo sapiens_hsa047280.99201680
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91160223
39beta-Alanine metabolism_Homo sapiens_hsa004100.89884167
40Selenocompound metabolism_Homo sapiens_hsa004500.86447348
41Basal transcription factors_Homo sapiens_hsa030220.86319324
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.85340350
43Renin secretion_Homo sapiens_hsa049240.84028194
44Oxytocin signaling pathway_Homo sapiens_hsa049210.83154895
45RNA transport_Homo sapiens_hsa030130.80862307
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80345175
47Tyrosine metabolism_Homo sapiens_hsa003500.79748048
48Oocyte meiosis_Homo sapiens_hsa041140.79635877
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78844147
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76604375
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.75815695
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71437307
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70596068
54Pyrimidine metabolism_Homo sapiens_hsa002400.67346386
55Long-term depression_Homo sapiens_hsa047300.66053222
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65898711
57Sphingolipid metabolism_Homo sapiens_hsa006000.65395850
58ABC transporters_Homo sapiens_hsa020100.64633844
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63879516
60One carbon pool by folate_Homo sapiens_hsa006700.63553264
61Synaptic vesicle cycle_Homo sapiens_hsa047210.61988603
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61563536
63Amphetamine addiction_Homo sapiens_hsa050310.59104969
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58944374
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58799289
66Morphine addiction_Homo sapiens_hsa050320.58655612
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57485747
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57117574
69Gastric acid secretion_Homo sapiens_hsa049710.55455282
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55291310
71Glycerolipid metabolism_Homo sapiens_hsa005610.55290195
72Pyruvate metabolism_Homo sapiens_hsa006200.55084643
73Glutamatergic synapse_Homo sapiens_hsa047240.55062068
74GABAergic synapse_Homo sapiens_hsa047270.53222550
75Collecting duct acid secretion_Homo sapiens_hsa049660.52628816
76Glucagon signaling pathway_Homo sapiens_hsa049220.50460733
77Type II diabetes mellitus_Homo sapiens_hsa049300.50373662
78Non-homologous end-joining_Homo sapiens_hsa034500.50213948
79Apoptosis_Homo sapiens_hsa042100.47463521
80PPAR signaling pathway_Homo sapiens_hsa033200.46753864
81Retinol metabolism_Homo sapiens_hsa008300.46309616
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46242641
83cAMP signaling pathway_Homo sapiens_hsa040240.44400940
84Chemical carcinogenesis_Homo sapiens_hsa052040.42343518
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41394073
86Vitamin digestion and absorption_Homo sapiens_hsa049770.41381777
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40595213
88Insulin signaling pathway_Homo sapiens_hsa049100.39797540
89Endocytosis_Homo sapiens_hsa041440.38653816
90Regulation of autophagy_Homo sapiens_hsa041400.35889657
91Insulin secretion_Homo sapiens_hsa049110.34679747
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34026325
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.34012754
94Metabolic pathways_Homo sapiens_hsa011000.31284799
95Hippo signaling pathway_Homo sapiens_hsa043900.29979511
96Nucleotide excision repair_Homo sapiens_hsa034200.29641237
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28545744
98Fatty acid metabolism_Homo sapiens_hsa012120.26435834
99Adherens junction_Homo sapiens_hsa045200.25044525
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24798234

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