ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to Golgi (GO:0072600)	5.31312347
2	protein targeting to Golgi (GO:0000042)	5.18066239
3	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.77639539
4	sperm motility (GO:0030317)	4.70969744
5	acrosome reaction (GO:0007340)	4.49338817
6	seminiferous tubule development (GO:0072520)	4.26901604
7	protein polyglutamylation (GO:0018095)	4.25541386
8	response to pheromone (GO:0019236)	4.20600139
9	Golgi to endosome transport (GO:0006895)	4.15862775
10	protein localization to Golgi apparatus (GO:0034067)	3.90719789
11	fusion of sperm to egg plasma membrane (GO:0007342)	3.84580470
12	single strand break repair (GO:0000012)	3.82081486
13	centriole replication (GO:0007099)	3.79222631
14	spermatid development (GO:0007286)	3.64716764
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.60941224
16	regulation of cilium movement (GO:0003352)	3.57877073
17	cellular ketone body metabolic process (GO:0046950)	3.57120796
18	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.53329805
19	intra-Golgi vesicle-mediated transport (GO:0006891)	3.51760501
20	DNA integration (GO:0015074)	3.51571494
21	phosphatidylethanolamine metabolic process (GO:0046337)	3.51253583
22	intraciliary transport (GO:0042073)	3.50435602
23	protein K11-linked deubiquitination (GO:0035871)	3.49237964
24	brain morphogenesis (GO:0048854)	3.37865698
25	histone H2A acetylation (GO:0043968)	3.32681386
26	microtubule severing (GO:0051013)	3.30323130
27	aggressive behavior (GO:0002118)	3.23801798
28	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.16638831
29	regulation of centriole replication (GO:0046599)	3.15526370
30	regulation of hexokinase activity (GO:1903299)	3.15122758
31	regulation of glucokinase activity (GO:0033131)	3.15122758
32	plasma membrane fusion (GO:0045026)	3.12037704
33	RNA destabilization (GO:0050779)	3.11201089
34	ketone body metabolic process (GO:1902224)	3.07008620
35	epithelial cilium movement (GO:0003351)	3.06542215
36	axoneme assembly (GO:0035082)	3.04970610
37	centriole assembly (GO:0098534)	3.02553390
38	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.01649476
39	peptidyl-lysine trimethylation (GO:0018023)	3.00276070
40	photoreceptor cell maintenance (GO:0045494)	2.98850533
41	cell differentiation involved in metanephros development (GO:0072202)	2.98381135
42	definitive hemopoiesis (GO:0060216)	2.93963496
43	sperm-egg recognition (GO:0035036)	2.92259728
44	microtubule nucleation (GO:0007020)	2.91664676
45	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.91644048
46	histone lysine demethylation (GO:0070076)	2.90880374
47	histone H3-K4 trimethylation (GO:0080182)	2.88218770
48	positive regulation of Rab GTPase activity (GO:0032851)	2.86710274
49	regulation of Rab GTPase activity (GO:0032313)	2.86710274
50	histone mRNA catabolic process (GO:0071044)	2.86372167
51	binding of sperm to zona pellucida (GO:0007339)	2.85827692
52	protein prenylation (GO:0018342)	2.84996225
53	prenylation (GO:0097354)	2.84996225
54	neural tube formation (GO:0001841)	2.84938259
55	cilium organization (GO:0044782)	2.84835665
56	calcium ion-dependent exocytosis (GO:0017156)	2.84715934
57	cilium assembly (GO:0042384)	2.84302567
58	histone demethylation (GO:0016577)	2.83731663
59	microtubule depolymerization (GO:0007019)	2.81516207
60	spermatid nucleus differentiation (GO:0007289)	2.79095814
61	monoubiquitinated protein deubiquitination (GO:0035520)	2.77877693
62	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.76030005
63	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.76030005
64	cilium movement (GO:0003341)	2.72574732
65	multicellular organismal movement (GO:0050879)	2.68348886
66	musculoskeletal movement (GO:0050881)	2.68348886
67	peptidyl-lysine methylation (GO:0018022)	2.68095362
68	auditory receptor cell differentiation (GO:0042491)	2.65060815
69	negative regulation of gene expression, epigenetic (GO:0045814)	2.64593164
70	protein localization to cilium (GO:0061512)	2.64132473
71	histone H3-K36 demethylation (GO:0070544)	2.63242838
72	response to misfolded protein (GO:0051788)	2.61717171
73	DNA double-strand break processing (GO:0000729)	2.61681775
74	negative regulation of neurological system process (GO:0031645)	2.61403007
75	male sex determination (GO:0030238)	2.61119520
76	histone H3-K9 demethylation (GO:0033169)	2.60859682
77	protein dealkylation (GO:0008214)	2.60263679
78	protein demethylation (GO:0006482)	2.60263679
79	regulation of telomere maintenance (GO:0032204)	2.60018307
80	chromatin silencing (GO:0006342)	2.59224520
81	pancreas development (GO:0031016)	2.58727901
82	mechanosensory behavior (GO:0007638)	2.55896612
83	histone H3-K9 methylation (GO:0051567)	2.53792341
84	nucleosome disassembly (GO:0006337)	2.53119708
85	protein-DNA complex disassembly (GO:0032986)	2.53119708
86	mitochondrial DNA replication (GO:0006264)	2.52629227
87	spermatogenesis (GO:0007283)	2.52553841
88	male gamete generation (GO:0048232)	2.51476914
89	histone lysine methylation (GO:0034968)	2.51323549
90	cell-cell recognition (GO:0009988)	2.50508684
91	zinc ion homeostasis (GO:0055069)	2.48747084
92	replication fork processing (GO:0031297)	2.48703756
93	centrosome duplication (GO:0051298)	2.48689986
94	chemosensory behavior (GO:0007635)	2.48580837
95	microtubule organizing center organization (GO:0031023)	2.48491108
96	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.48213176
97	regulation of translation, ncRNA-mediated (GO:0045974)	2.48213176
98	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.48213176
99	positive regulation of glycolytic process (GO:0045821)	2.46698595
100	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.46192297

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.01383498
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.42641552
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24538177
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.92678269
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87925171
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.82570375
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.75393736
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69944164
9	FUS_26573619_Chip-Seq_HEK293_Human	2.64840618
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.53693726
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.53244889
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.48825680
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42475384
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.31828604
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.24569182
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.24569182
17	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.19589968
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08500987
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07200199
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04424870
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.04120595
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.96740051
23	AR_21572438_ChIP-Seq_LNCaP_Human	1.93331094
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.92102494
25	P300_19829295_ChIP-Seq_ESCs_Human	1.88126926
26	STAT3_23295773_ChIP-Seq_U87_Human	1.76173597
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66937843
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64663509
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.64607859
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60149170
31	EWS_26573619_Chip-Seq_HEK293_Human	1.59497563
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57147305
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57147305
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49535552
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46637966
36	AR_25329375_ChIP-Seq_VCAP_Human	1.46408605
37	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.45922209
38	TCF4_23295773_ChIP-Seq_U87_Human	1.45313153
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44655256
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.35513726
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33590898
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.31222739
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30833249
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30061584
45	BCAT_22108803_ChIP-Seq_LS180_Human	1.26689137
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26259247
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.25948912
48	VDR_22108803_ChIP-Seq_LS180_Human	1.25483227
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24425363
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24057467
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.23544070
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22137092
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20862287
54	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.20821194
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20472103
56	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19442040
57	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.19347840
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16396822
59	DROSHA_22980978_ChIP-Seq_HELA_Human	1.14979364
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.12507067
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05471398
62	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04324780
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03915540
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03915540
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01765956
66	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01302411
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01179224
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.01177668
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00118880
70	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98836700
71	AHR_22903824_ChIP-Seq_MCF-7_Human	0.98617731
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97908271
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97341992
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.96197299
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96014820
76	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95788386
77	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95568597
78	MYC_18940864_ChIP-ChIP_HL60_Human	0.94598702
79	SOX9_26525672_Chip-Seq_HEART_Mouse	0.94586586
80	KDM2B_26808549_Chip-Seq_REH_Human	0.93791487
81	ERA_21632823_ChIP-Seq_H3396_Human	0.93732365
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93626441
83	CDX2_22108803_ChIP-Seq_LS180_Human	0.93475178
84	SCL_19346495_ChIP-Seq_HPC-7_Human	0.92987950
85	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.91604874
86	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.90687130
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89759277
88	TBL1_22424771_ChIP-Seq_293T_Human	0.89579933
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.88481067
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87923267
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.87552789
92	VDR_23849224_ChIP-Seq_CD4+_Human	0.87084441
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.86571073
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86246583
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.85048988
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.84852775
97	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84582144
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.84322756
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.83850394
100	NFYB_21822215_ChIP-Seq_K562_Human	0.83674953

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.30405941
2	MP0002822_catalepsy	3.25655159
3	MP0005410_abnormal_fertilization	3.25255213
4	MP0008877_abnormal_DNA_methylation	3.03109894
5	MP0008057_abnormal_DNA_replication	2.83105131
6	MP0002638_abnormal_pupillary_reflex	2.79496709
7	MP0005645_abnormal_hypothalamus_physiol	2.70553104
8	MP0003121_genomic_imprinting	2.33607842
9	MP0003880_abnormal_central_pattern	2.19221370
10	MP0001984_abnormal_olfaction	2.13275701
11	MP0006072_abnormal_retinal_apoptosis	2.02072039
12	MP0006276_abnormal_autonomic_nervous	1.99637026
13	MP0003718_maternal_effect	1.98918652
14	MP0002009_preneoplasia	1.94644718
15	MP0008995_early_reproductive_senescence	1.91872159
16	MP0002102_abnormal_ear_morphology	1.88870635
17	MP0003698_abnormal_male_reproductive	1.85958728
18	MP0003122_maternal_imprinting	1.85122808
19	MP0001486_abnormal_startle_reflex	1.84509740
20	MP0001485_abnormal_pinna_reflex	1.82783505
21	MP0005551_abnormal_eye_electrophysiolog	1.81627611
22	MP0001929_abnormal_gametogenesis	1.81163165
23	MP0005253_abnormal_eye_physiology	1.76969730
24	MP0001986_abnormal_taste_sensitivity	1.60335148
25	MP0000569_abnormal_digit_pigmentation	1.58743925
26	MP0005377_hearing/vestibular/ear_phenot	1.56656032
27	MP0003878_abnormal_ear_physiology	1.56656032
28	MP0008058_abnormal_DNA_repair	1.51000626
29	MP0009697_abnormal_copulation	1.50577404
30	MP0005220_abnormal_exocrine_pancreas	1.49248080
31	MP0010094_abnormal_chromosome_stability	1.31557816
32	MP0005379_endocrine/exocrine_gland_phen	1.26008325
33	MP0000631_abnormal_neuroendocrine_gland	1.21714714
34	MP0003195_calcinosis	1.19417251
35	MP0005499_abnormal_olfactory_system	1.18806223
36	MP0005394_taste/olfaction_phenotype	1.18806223
37	MP0001529_abnormal_vocalization	1.18689941
38	MP0001944_abnormal_pancreas_morphology	1.14626977
39	MP0000372_irregular_coat_pigmentation	1.13551919
40	MP0002837_dystrophic_cardiac_calcinosis	1.11738530
41	MP0002557_abnormal_social/conspecific_i	1.10252602
42	MP0004134_abnormal_chest_morphology	1.09213840
43	MP0009046_muscle_twitch	1.08860512
44	MP0000653_abnormal_sex_gland	1.07403550
45	MP0008961_abnormal_basal_metabolism	1.06982242
46	MP0001145_abnormal_male_reproductive	1.06617174
47	MP0002735_abnormal_chemical_nociception	1.03961077
48	MP0001545_abnormal_hematopoietic_system	1.03312219
49	MP0005397_hematopoietic_system_phenotyp	1.03312219
50	MP0005075_abnormal_melanosome_morpholog	1.03104673
51	MP0002734_abnormal_mechanical_nocicepti	1.03053246
52	MP0000778_abnormal_nervous_system	1.02614079
53	MP0004145_abnormal_muscle_electrophysio	1.02432566
54	MP0002909_abnormal_adrenal_gland	1.01029260
55	MP0002184_abnormal_innervation	1.00246164
56	MP0002210_abnormal_sex_determination	0.99036280
57	MP0006035_abnormal_mitochondrial_morpho	0.98387055
58	MP0006292_abnormal_olfactory_placode	0.97798362
59	MP0005391_vision/eye_phenotype	0.97259339
60	MP0001764_abnormal_homeostasis	0.95671187
61	MP0004133_heterotaxia	0.94899101
62	MP0002928_abnormal_bile_duct	0.93969291
63	MP0005647_abnormal_sex_gland	0.93847098
64	MP0005395_other_phenotype	0.93714398
65	MP0008789_abnormal_olfactory_epithelium	0.93173740
66	MP0010386_abnormal_urinary_bladder	0.90987849
67	MP0000013_abnormal_adipose_tissue	0.90469548
68	MP0002161_abnormal_fertility/fecundity	0.90353775
69	MP0008007_abnormal_cellular_replicative	0.89706760
70	MP0005670_abnormal_white_adipose	0.89080264
71	MP0004924_abnormal_behavior	0.87407397
72	MP0005386_behavior/neurological_phenoty	0.87407397
73	MP0001968_abnormal_touch/_nociception	0.87386937
74	MP0002572_abnormal_emotion/affect_behav	0.86410319
75	MP0003943_abnormal_hepatobiliary_system	0.86242601
76	MP0005646_abnormal_pituitary_gland	0.86096145
77	MP0000516_abnormal_urinary_system	0.85904094
78	MP0005367_renal/urinary_system_phenotyp	0.85904094
79	MP0002249_abnormal_larynx_morphology	0.84779667
80	MP0005451_abnormal_body_composition	0.84299496
81	MP0001963_abnormal_hearing_physiology	0.83536917
82	MP0004085_abnormal_heartbeat	0.82655597
83	MP0009703_decreased_birth_body	0.82394238
84	MP0002067_abnormal_sensory_capabilities	0.82329478
85	MP0000427_abnormal_hair_cycle	0.81339038
86	MP0003786_premature_aging	0.80618352
87	MP0000026_abnormal_inner_ear	0.79801552
88	MP0002069_abnormal_eating/drinking_beha	0.79642806
89	MP0002752_abnormal_somatic_nervous	0.78241715
90	MP0002229_neurodegeneration	0.77918734
91	MP0002751_abnormal_autonomic_nervous	0.77169459
92	MP0004043_abnormal_pH_regulation	0.75856334
93	MP0002078_abnormal_glucose_homeostasis	0.73998925
94	MP0002166_altered_tumor_susceptibility	0.73695010
95	MP0002938_white_spotting	0.73234556
96	MP0003123_paternal_imprinting	0.72651798
97	MP0003633_abnormal_nervous_system	0.72385810
98	MP0001970_abnormal_pain_threshold	0.71885825
99	MP0000955_abnormal_spinal_cord	0.71822009
100	MP0002272_abnormal_nervous_system	0.69541494

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	5.22008140
2	Chronic hepatic failure (HP:0100626)	5.06912737
3	Genetic anticipation (HP:0003743)	3.36258430
4	Progressive cerebellar ataxia (HP:0002073)	3.34453716
5	True hermaphroditism (HP:0010459)	3.29261761
6	Nephronophthisis (HP:0000090)	3.24332573
7	Ependymoma (HP:0002888)	3.08336206
8	Pancreatic cysts (HP:0001737)	2.88736125
9	Intestinal atresia (HP:0011100)	2.87780344
10	Pancreatic fibrosis (HP:0100732)	2.87555172
11	Thyroiditis (HP:0100646)	2.86049023
12	Abnormal biliary tract physiology (HP:0012439)	2.82053044
13	Bile duct proliferation (HP:0001408)	2.82053044
14	Hyperventilation (HP:0002883)	2.81403562
15	Hypoglycemic seizures (HP:0002173)	2.77946987
16	Abnormality of the renal medulla (HP:0100957)	2.76420352
17	Hemiparesis (HP:0001269)	2.71685706
18	Abnormality of macular pigmentation (HP:0008002)	2.69362917
19	Abnormality of the astrocytes (HP:0100707)	2.64782813
20	Astrocytoma (HP:0009592)	2.64782813
21	Hypoplasia of the thymus (HP:0000778)	2.64288978
22	Medial flaring of the eyebrow (HP:0010747)	2.63061465
23	Volvulus (HP:0002580)	2.54370262
24	Abnormality of the renal cortex (HP:0011035)	2.52085736
25	Ketoacidosis (HP:0001993)	2.49197956
26	Attenuation of retinal blood vessels (HP:0007843)	2.45794531
27	Gaze-evoked nystagmus (HP:0000640)	2.43038205
28	Neoplasm of the heart (HP:0100544)	2.40215551
29	Cystic liver disease (HP:0006706)	2.37900310
30	Hepatoblastoma (HP:0002884)	2.37118916
31	Poor coordination (HP:0002370)	2.37086642
32	Cerebellar dysplasia (HP:0007033)	2.35426412
33	Genital tract atresia (HP:0001827)	2.31227753
34	Hypothermia (HP:0002045)	2.29393449
35	Truncal obesity (HP:0001956)	2.29155434
36	Congenital primary aphakia (HP:0007707)	2.28438083
37	Hyperinsulinemic hypoglycemia (HP:0000825)	2.28253042
38	Glioma (HP:0009733)	2.27602015
39	Hyperglycinemia (HP:0002154)	2.26048699
40	Renal cortical cysts (HP:0000803)	2.24765663
41	Neoplasm of the adrenal cortex (HP:0100641)	2.23606475
42	Vaginal atresia (HP:0000148)	2.22842493
43	Limb hypertonia (HP:0002509)	2.20962057
44	Abnormal hair whorl (HP:0010721)	2.20341461
45	Gait imbalance (HP:0002141)	2.19863523
46	Abnormality of the pancreatic islet cells (HP:0006476)	2.19661566
47	Abnormality of endocrine pancreas physiology (HP:0012093)	2.19661566
48	Abnormality of the ischium (HP:0003174)	2.17410142
49	Resting tremor (HP:0002322)	2.15770868
50	Hypoplastic ischia (HP:0003175)	2.13042620
51	Hypoglycemic coma (HP:0001325)	2.12780121
52	Tubulointerstitial abnormality (HP:0001969)	2.11201219
53	Nephrogenic diabetes insipidus (HP:0009806)	2.11083286
54	Bony spicule pigmentary retinopathy (HP:0007737)	2.10260314
55	Cone-rod dystrophy (HP:0000548)	2.09773088
56	Drooling (HP:0002307)	2.07380200
57	Severe visual impairment (HP:0001141)	2.05153423
58	Large for gestational age (HP:0001520)	2.04676780
59	Occipital encephalocele (HP:0002085)	2.02158772
60	Chorioretinal atrophy (HP:0000533)	2.01452303
61	Agitation (HP:0000713)	2.00052030
62	Abnormality of the parathyroid morphology (HP:0011766)	1.96948831
63	Type II lissencephaly (HP:0007260)	1.95275350
64	Sloping forehead (HP:0000340)	1.94194533
65	Abnormality of chromosome stability (HP:0003220)	1.93946006
66	Acute lymphatic leukemia (HP:0006721)	1.93731660
67	Congenital hepatic fibrosis (HP:0002612)	1.92488720
68	Medulloblastoma (HP:0002885)	1.91324034
69	Bicornuate uterus (HP:0000813)	1.89850190
70	Severe combined immunodeficiency (HP:0004430)	1.89658700
71	Neoplasm of striated muscle (HP:0009728)	1.89491095
72	Ketosis (HP:0001946)	1.88152760
73	Impulsivity (HP:0100710)	1.86692533
74	Tachypnea (HP:0002789)	1.86677537
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86082263
76	Excessive salivation (HP:0003781)	1.85701642
77	Stage 5 chronic kidney disease (HP:0003774)	1.85078850
78	Failure to thrive in infancy (HP:0001531)	1.84448442
79	Abnormal pancreas size (HP:0012094)	1.83242300
80	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.77423625
81	Optic nerve coloboma (HP:0000588)	1.77260747
82	Abnormality of the ileum (HP:0001549)	1.74279860
83	Tubular atrophy (HP:0000092)	1.73761051
84	Abnormality of the labia minora (HP:0012880)	1.72554542
85	Tented upper lip vermilion (HP:0010804)	1.72517961
86	Molar tooth sign on MRI (HP:0002419)	1.72244385
87	Abnormality of midbrain morphology (HP:0002418)	1.72244385
88	Hyperglycinuria (HP:0003108)	1.71921510
89	Microvesicular hepatic steatosis (HP:0001414)	1.70370526
90	Urethral obstruction (HP:0000796)	1.70343354
91	Renal hypoplasia (HP:0000089)	1.69332708
92	Abolished electroretinogram (ERG) (HP:0000550)	1.68621526
93	Protruding tongue (HP:0010808)	1.67649446
94	Specific learning disability (HP:0001328)	1.67299978
95	Colon cancer (HP:0003003)	1.67040767
96	Type II diabetes mellitus (HP:0005978)	1.66697437
97	Abnormality of DNA repair (HP:0003254)	1.66638498
98	Abnormality of the pubic bones (HP:0003172)	1.63573749
99	Abnormality of the fingertips (HP:0001211)	1.61449606
100	Male pseudohermaphroditism (HP:0000037)	1.61014958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.90148717
2	INSRR	4.38258430
3	MAP4K2	3.75839975
4	AKT3	2.93924738
5	TRIM28	2.92405519
6	PLK4	2.66524189
7	BMPR1B	2.39821145
8	CASK	2.19578229
9	GRK1	2.15992298
10	MAP3K4	2.12897157
11	PINK1	1.91660170
12	NUAK1	1.87437020
13	ZAK	1.77826655
14	EPHA3	1.77170481
15	MAPK13	1.76769456
16	WNK3	1.67989348
17	PRKD3	1.67700282
18	FGFR2	1.52958430
19	BRD4	1.49905461
20	TAOK3	1.47010403
21	LATS1	1.41570329
22	CAMK1G	1.41223504
23	MAP2K7	1.40617894
24	PAK3	1.39588776
25	CSNK1A1L	1.23258043
26	NTRK3	1.20329355
27	VRK1	1.16667777
28	BMPR2	1.13065475
29	CSNK1G1	1.12396598
30	BCKDK	1.12264299
31	MKNK2	1.11910646
32	ERBB3	1.11390263
33	ACVR1B	1.09955037
34	ADRBK2	1.06294577
35	FER	1.04261851
36	EPHA4	1.02109370
37	CSNK1G3	1.01375437
38	BRSK2	1.00460797
39	RPS6KA5	0.98813780
40	PRKAA1	0.94363987
41	CSNK1G2	0.93924137
42	PLK2	0.93226396
43	CAMK1D	0.92366089
44	SRPK1	0.90066557
45	MKNK1	0.89539875
46	STK39	0.86951876
47	BCR	0.86806506
48	NLK	0.86459892
49	PRKAA2	0.82807922
50	SGK2	0.79138607
51	PTK2B	0.76652629
52	CDK12	0.76305580
53	CDK3	0.76145983
54	PRKD2	0.72410282
55	ATR	0.69053260
56	DYRK1B	0.68335728
57	MAPK15	0.66147032
58	PRKCE	0.65744419
59	TNK2	0.65600870
60	SGK223	0.64265964
61	SGK494	0.64265964
62	TLK1	0.63965518
63	MAPK11	0.63817319
64	FGFR3	0.63021211
65	PNCK	0.60344287
66	ATM	0.60129235
67	DYRK1A	0.55472367
68	FLT3	0.55340102
69	STK38L	0.54307848
70	PIK3CG	0.52956892
71	CAMK4	0.52708742
72	STK3	0.52551109
73	STK38	0.50517716
74	PKN1	0.49309325
75	ERBB2	0.49123616
76	TEC	0.48614615
77	CAMKK2	0.47450847
78	MAP4K1	0.45561056
79	KIT	0.44918463
80	NEK6	0.43209476
81	BTK	0.42048497
82	DYRK3	0.41363474
83	MAPKAPK5	0.41052268
84	PRKCH	0.40013194
85	WNK4	0.39362560
86	GSK3B	0.39189508
87	NTRK2	0.38150852
88	DAPK2	0.37665370
89	CAMK1	0.36334152
90	MAP3K7	0.36321944
91	CDK2	0.35659633
92	CHEK1	0.35135653
93	MARK1	0.34709481
94	MAPK1	0.34320205
95	EGFR	0.33823271
96	CDK1	0.33365844
97	CSNK1D	0.31624333
98	WNK1	0.30187814
99	HCK	0.29085891
100	CSF1R	0.29016422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.83022297
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.19339163
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.84074715
4	ABC transporters_Homo sapiens_hsa02010	2.80450459
5	Butanoate metabolism_Homo sapiens_hsa00650	2.75730326
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.71489720
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62344683
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.48280602
9	Phototransduction_Homo sapiens_hsa04744	2.11458148
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04106114
11	Alcoholism_Homo sapiens_hsa05034	2.02915906
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.95893559
13	Olfactory transduction_Homo sapiens_hsa04740	1.93789355
14	Regulation of autophagy_Homo sapiens_hsa04140	1.85623466
15	Lysine degradation_Homo sapiens_hsa00310	1.79131494
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78557654
17	Taste transduction_Homo sapiens_hsa04742	1.70865372
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.68300121
19	Peroxisome_Homo sapiens_hsa04146	1.63962127
20	Propanoate metabolism_Homo sapiens_hsa00640	1.52768252
21	Basal transcription factors_Homo sapiens_hsa03022	1.50813014
22	Base excision repair_Homo sapiens_hsa03410	1.50732457
23	Homologous recombination_Homo sapiens_hsa03440	1.42434187
24	Insulin secretion_Homo sapiens_hsa04911	1.42158226
25	Type II diabetes mellitus_Homo sapiens_hsa04930	1.39897326
26	mTOR signaling pathway_Homo sapiens_hsa04150	1.35442995
27	Nicotine addiction_Homo sapiens_hsa05033	1.30659603
28	Fatty acid metabolism_Homo sapiens_hsa01212	1.23685732
29	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.18995779
30	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.18853522
31	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.16775223
32	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.13990170
33	RNA transport_Homo sapiens_hsa03013	1.13626254
34	Oocyte meiosis_Homo sapiens_hsa04114	1.07985678
35	Circadian rhythm_Homo sapiens_hsa04710	1.07884444
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04588437
37	Protein export_Homo sapiens_hsa03060	1.01419749
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00400264
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97119271
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95124894
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91556724
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.87177162
43	Circadian entrainment_Homo sapiens_hsa04713	0.85496170
44	Asthma_Homo sapiens_hsa05310	0.84113220
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83532889
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.83236321
47	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.83177679
48	Salivary secretion_Homo sapiens_hsa04970	0.76654650
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.75503721
50	Fatty acid elongation_Homo sapiens_hsa00062	0.74834673
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.72388458
52	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.72105313
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.71579229
54	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.71092141
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70063555
56	RNA degradation_Homo sapiens_hsa03018	0.68904823
57	Renin secretion_Homo sapiens_hsa04924	0.66951776
58	Mismatch repair_Homo sapiens_hsa03430	0.66911060
59	Purine metabolism_Homo sapiens_hsa00230	0.66406262
60	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64857932
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.64273428
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.63948247
63	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62099502
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.61630729
65	Morphine addiction_Homo sapiens_hsa05032	0.61360915
66	Endometrial cancer_Homo sapiens_hsa05213	0.61210476
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59613456
68	Long-term depression_Homo sapiens_hsa04730	0.59230315
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.57670574
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57527071
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57223683
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.55848965
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53346779
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.52933483
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51919707
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48764509
77	Serotonergic synapse_Homo sapiens_hsa04726	0.48137942
78	GABAergic synapse_Homo sapiens_hsa04727	0.47580708
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47245699
80	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44567133
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.43636788
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43245630
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42748897
84	Amphetamine addiction_Homo sapiens_hsa05031	0.42361696
85	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42295666
86	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41840659
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41420143
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.40315273
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.40075720
90	Non-small cell lung cancer_Homo sapiens_hsa05223	0.39962835
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.39735538
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39698902
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.39582007
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.39239901
95	AMPK signaling pathway_Homo sapiens_hsa04152	0.38947364
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38867538
97	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.37490210
98	Cholinergic synapse_Homo sapiens_hsa04725	0.36966409
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36184738
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.34693214

GUSBP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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