GVINP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.26566814
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.88250483
3negative regulation of cell killing (GO:0031342)6.88250483
4regulation of B cell receptor signaling pathway (GO:0050855)6.17356589
5negative T cell selection (GO:0043383)5.96698442
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.92622003
7negative thymic T cell selection (GO:0045060)5.73100532
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.65584468
9regulation of gamma-delta T cell differentiation (GO:0045586)5.52115378
10regulation of gamma-delta T cell activation (GO:0046643)5.40485938
11positive T cell selection (GO:0043368)5.34375658
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.32433952
13positive thymic T cell selection (GO:0045059)5.22677445
14antigen processing and presentation of endogenous antigen (GO:0019883)5.06981757
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.91871737
16response to interleukin-15 (GO:0070672)4.77696207
17negative regulation of T cell mediated immunity (GO:0002710)4.68245672
18T cell selection (GO:0045058)4.54515415
19activated T cell proliferation (GO:0050798)4.53054509
20cellular response to interleukin-15 (GO:0071350)4.51379604
21T cell migration (GO:0072678)4.47497829
22B cell receptor signaling pathway (GO:0050853)4.45283272
23thymic T cell selection (GO:0045061)4.39789852
24positive regulation by symbiont of host defense response (GO:0052509)4.34945063
25modulation by symbiont of host defense response (GO:0052031)4.34945063
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.34945063
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.34945063
28positive regulation by organism of defense response of other organism involved in symbiotic interact4.34945063
29modulation by symbiont of host immune response (GO:0052553)4.34945063
30leukocyte aggregation (GO:0070486)4.24141086
31positive regulation of granulocyte differentiation (GO:0030854)4.20797567
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.15347028
33regulation of B cell differentiation (GO:0045577)4.01122874
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98909162
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.92551180
36regulation of alpha-beta T cell proliferation (GO:0046640)3.90517011
37interferon-gamma production (GO:0032609)3.88167778
38positive regulation of B cell differentiation (GO:0045579)3.82317338
39cellular extravasation (GO:0045123)3.74314083
40regulation of regulatory T cell differentiation (GO:0045589)3.72698672
41microglial cell activation (GO:0001774)3.68741788
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.63241310
43macrophage activation involved in immune response (GO:0002281)3.62047057
44tolerance induction (GO:0002507)3.62023866
45detection of other organism (GO:0098543)3.59399887
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.56273171
47negative regulation of leukocyte mediated immunity (GO:0002704)3.54922501
48detection of molecule of bacterial origin (GO:0032490)3.50974048
49antigen receptor-mediated signaling pathway (GO:0050851)3.46445180
50regulation of isotype switching to IgG isotypes (GO:0048302)3.46172741
51antigen processing and presentation via MHC class Ib (GO:0002475)3.45448154
52negative regulation of interleukin-12 production (GO:0032695)3.43671410
53regulation of interferon-beta biosynthetic process (GO:0045357)3.40530048
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.40399633
55negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.40355781
56regulation of T cell tolerance induction (GO:0002664)3.39029918
57regulation of T cell mediated cytotoxicity (GO:0001914)3.33014606
58detection of bacterium (GO:0016045)3.32287204
59T cell receptor signaling pathway (GO:0050852)3.30987661
60detection of external biotic stimulus (GO:0098581)3.30641039
61hepatocyte apoptotic process (GO:0097284)3.30074597
62response to type I interferon (GO:0034340)3.29510204
63type I interferon signaling pathway (GO:0060337)3.28856467
64cellular response to type I interferon (GO:0071357)3.28856467
65regulation of tolerance induction (GO:0002643)3.27632353
66mast cell activation (GO:0045576)3.26693169
67positive regulation of tolerance induction (GO:0002645)3.24425075
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22443252
69histone H3-K36 demethylation (GO:0070544)3.21805950
70negative regulation of adaptive immune response (GO:0002820)3.17351804
71response to host immune response (GO:0052572)3.15210323
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15210323
73negative regulation of B cell proliferation (GO:0030889)3.13709970
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.13685294
75regulation of natural killer cell mediated immunity (GO:0002715)3.13685294
76T cell proliferation (GO:0042098)3.07662059
77myeloid cell activation involved in immune response (GO:0002275)3.06445483
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06204714
79neutrophil activation involved in immune response (GO:0002283)3.03106452
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99813866
81regulation of granulocyte differentiation (GO:0030852)2.97484305
82positive regulation of isotype switching (GO:0045830)2.97234162
83interferon-gamma-mediated signaling pathway (GO:0060333)2.95877914
84response to host (GO:0075136)2.95594802
85response to host defenses (GO:0052200)2.95594802
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95594802
87macrophage activation (GO:0042116)2.94990551
88negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94981689
89regulation of leukocyte mediated cytotoxicity (GO:0001910)2.94524708
90positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92770840
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.90622634
92negative regulation of T-helper cell differentiation (GO:0045623)2.90622634
93T cell homeostasis (GO:0043029)2.89135680
94B cell proliferation (GO:0042100)2.88158040
95regulation of interleukin-2 biosynthetic process (GO:0045076)2.88131905
96alpha-beta T cell activation (GO:0046631)2.88049756
97detection of biotic stimulus (GO:0009595)2.87894349
98immunoglobulin mediated immune response (GO:0016064)2.87483078
99alpha-beta T cell differentiation (GO:0046632)2.85054841
100regulation of necroptotic process (GO:0060544)2.84018745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.32538414
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.26882694
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.06264873
4RUNX_20019798_ChIP-Seq_JUKART_Human3.93278203
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.86671075
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.68817064
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.50286640
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.48963071
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32132700
10MYB_26560356_Chip-Seq_TH2_Human3.25303812
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.05877857
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92814510
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.87364308
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.70991101
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.62354868
16MYB_26560356_Chip-Seq_TH1_Human2.60872125
17SCL_19346495_ChIP-Seq_HPC-7_Human2.56087531
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49523253
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45488189
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38610910
21MAF_26560356_Chip-Seq_TH1_Human2.35700052
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30715667
23GATA3_27048872_Chip-Seq_THYMUS_Human2.29757260
24SPI1_23547873_ChIP-Seq_NB4_Human2.25239215
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20021601
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08564844
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04559389
28UTX_26944678_Chip-Seq_JUKART_Human2.03510744
29SPI1_23127762_ChIP-Seq_K562_Human2.02845882
30MYC_22102868_ChIP-Seq_BL_Human1.95354154
31GATA3_26560356_Chip-Seq_TH2_Human1.86305097
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85821595
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79935071
34GATA1_22025678_ChIP-Seq_K562_Human1.77944314
35VDR_24763502_ChIP-Seq_THP-1_Human1.74693739
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73363982
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.73288528
38MAF_26560356_Chip-Seq_TH2_Human1.65739760
39VDR_24787735_ChIP-Seq_THP-1_Human1.64759868
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60175846
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56750247
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.53993749
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53561956
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45287131
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44987416
46PU_27001747_Chip-Seq_BMDM_Mouse1.44921235
47VDR_21846776_ChIP-Seq_THP-1_Human1.43793557
48TCF7_22412390_ChIP-Seq_EML_Mouse1.42663035
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39832227
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.35666112
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.32422149
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30891158
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30701535
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28687411
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26432122
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23083760
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22843186
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22004506
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18037482
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17189838
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16641462
62CIITA_25753668_ChIP-Seq_RAJI_Human1.16639057
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.15963068
64KDM2B_26808549_Chip-Seq_DND41_Human1.12769629
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11890280
66GATA1_19941826_ChIP-Seq_K562_Human1.11766929
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11621810
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06042792
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03227079
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02577277
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01822547
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.01077267
73GATA2_19941826_ChIP-Seq_K562_Human0.98851926
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97823569
75SMRT_27268052_Chip-Seq_Bcells_Human0.97378994
76GATA2_21666600_ChIP-Seq_HMVEC_Human0.94365755
77KDM2B_26808549_Chip-Seq_JURKAT_Human0.93523263
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90736847
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86630203
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86478026
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85920581
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84212546
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83996413
84GATA3_26560356_Chip-Seq_TH1_Human0.83855018
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83216562
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80754055
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77182639
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75780032
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75567850
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74686038
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73933395
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.73420504
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73374775
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.71718056
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70140588
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69866824
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68052345
98TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.67649397
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66268216
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65657544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.26073291
2MP0001835_abnormal_antigen_presentation4.12023900
3MP0003724_increased_susceptibility_to3.99440498
4MP0005671_abnormal_response_to3.62323407
5MP0001800_abnormal_humoral_immune3.45301628
6MP0003436_decreased_susceptibility_to3.25473556
7MP0000685_abnormal_immune_system2.93877140
8MP0005000_abnormal_immune_tolerance2.89211749
9MP0002723_abnormal_immune_serum2.79419893
10MP0005387_immune_system_phenotype2.72795729
11MP0001790_abnormal_immune_system2.72795729
12MP0002420_abnormal_adaptive_immunity2.71141072
13MP0001819_abnormal_immune_cell2.67487213
14MP0003303_peritoneal_inflammation2.66995728
15MP0002452_abnormal_antigen_presenting2.66630514
16MP0000569_abnormal_digit_pigmentation2.55865183
17MP0005025_abnormal_response_to2.55011523
18MP0002419_abnormal_innate_immunity2.48241839
19MP0009785_altered_susceptibility_to2.46001029
20MP0002398_abnormal_bone_marrow2.37866542
21MP0000716_abnormal_immune_system2.21050874
22MP0003300_gastrointestinal_ulcer2.20634253
23MP0002166_altered_tumor_susceptibility2.19201945
24MP0000703_abnormal_thymus_morphology2.18248056
25MP0009333_abnormal_splenocyte_physiolog2.14236975
26MP0002405_respiratory_system_inflammati2.13327309
27MP0004381_abnormal_hair_follicle2.12349221
28MP0008260_abnormal_autophagy2.07038707
29MP0000689_abnormal_spleen_morphology2.02613067
30MP0006082_CNS_inflammation2.01360561
31MP0002722_abnormal_immune_system1.96407545
32MP0003866_abnormal_defecation1.94056974
33MP0005464_abnormal_platelet_physiology1.93620602
34MP0002148_abnormal_hypersensitivity_rea1.92770818
35MP0010155_abnormal_intestine_physiology1.82612709
36MP0002429_abnormal_blood_cell1.73236776
37MP0004947_skin_inflammation1.73096353
38MP0005075_abnormal_melanosome_morpholog1.68566377
39MP0002396_abnormal_hematopoietic_system1.66629260
40MP0001845_abnormal_inflammatory_respons1.65331390
41MP0008057_abnormal_DNA_replication1.65151014
42MP0005310_abnormal_salivary_gland1.57414428
43MP0003172_abnormal_lysosome_physiology1.54618562
44MP0001533_abnormal_skeleton_physiology1.49395002
45MP0002009_preneoplasia1.46447271
46MP0002006_tumorigenesis1.45077933
47MP0000465_gastrointestinal_hemorrhage1.44673318
48MP0005451_abnormal_body_composition1.43619980
49MP0004883_abnormal_blood_vessel1.42324852
50MP0003828_pulmonary_edema1.35113072
51MP0001873_stomach_inflammation1.34661268
52MP0003787_abnormal_imprinting1.34297363
53MP0001851_eye_inflammation1.33660810
54MP0000858_altered_metastatic_potential1.20951331
55MP0003656_abnormal_erythrocyte_physiolo1.20353860
56MP0000015_abnormal_ear_pigmentation1.18624172
57MP0008469_abnormal_protein_level1.16015318
58MP0003183_abnormal_peptide_metabolism1.15422616
59MP0001853_heart_inflammation1.11779588
60MP0002933_joint_inflammation1.08680033
61MP0004808_abnormal_hematopoietic_stem1.07283455
62MP0004130_abnormal_muscle_cell1.05924290
63MP0009764_decreased_sensitivity_to1.05893914
64MP0002998_abnormal_bone_remodeling1.03642727
65MP0003191_abnormal_cellular_cholesterol0.99943699
66MP0002132_abnormal_respiratory_system0.96308150
67MP0005174_abnormal_tail_pigmentation0.94300170
68MP0003690_abnormal_glial_cell0.94276934
69MP0002138_abnormal_hepatobiliary_system0.88649247
70MP0009278_abnormal_bone_marrow0.88640099
71MP0005397_hematopoietic_system_phenotyp0.88591726
72MP0001545_abnormal_hematopoietic_system0.88591726
73MP0002277_abnormal_respiratory_mucosa0.87516826
74MP0003221_abnormal_cardiomyocyte_apopto0.86201555
75MP0005164_abnormal_response_to0.85492681
76MP0003045_fibrosis0.85478958
77MP0009763_increased_sensitivity_to0.82046074
78MP0003091_abnormal_cell_migration0.78309845
79MP0002019_abnormal_tumor_incidence0.78005250
80MP0001663_abnormal_digestive_system0.77234486
81MP0008877_abnormal_DNA_methylation0.76671222
82MP0003448_altered_tumor_morphology0.75109250
83MP0002332_abnormal_exercise_endurance0.74226972
84MP0000604_amyloidosis0.73162851
85MP0004484_altered_response_of0.73048520
86MP0000249_abnormal_blood_vessel0.70909148
87MP0009765_abnormal_xenobiotic_induced0.67049516
88MP0005166_decreased_susceptibility_to0.59335445
89MP0001986_abnormal_taste_sensitivity0.58534101
90MP0008961_abnormal_basal_metabolism0.54148783
91MP0000371_diluted_coat_color0.54139358
92MP0005376_homeostasis/metabolism_phenot0.50964537
93MP0008874_decreased_physiological_sensi0.50134421
94MP0000490_abnormal_crypts_of0.49764137
95MP0002928_abnormal_bile_duct0.49427574
96MP0002693_abnormal_pancreas_physiology0.48504237
97MP0003252_abnormal_bile_duct0.46966373
98MP0003795_abnormal_bone_structure0.45772995
99MP0009115_abnormal_fat_cell0.45450907
100MP0002136_abnormal_kidney_physiology0.44572164

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.53978419
2Abnormality of T cell number (HP:0011839)6.09590658
3Eczematoid dermatitis (HP:0000976)5.46110235
4Recurrent bacterial skin infections (HP:0005406)5.32167751
5Recurrent abscess formation (HP:0002722)4.82129813
6Recurrent fungal infections (HP:0002841)4.67931023
7Myositis (HP:0100614)4.55876156
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.52594518
9Stomatitis (HP:0010280)4.51608997
10Elevated erythrocyte sedimentation rate (HP:0003565)4.51119923
11Abnormality of T cells (HP:0002843)4.42381030
12Retrobulbar optic neuritis (HP:0100654)4.36873285
13Optic neuritis (HP:0100653)4.36873285
14Orchitis (HP:0100796)4.17708717
15Chronic mucocutaneous candidiasis (HP:0002728)4.11589188
16Recurrent cutaneous fungal infections (HP:0011370)4.11589188
17Recurrent viral infections (HP:0004429)4.06802709
18Gastrointestinal infarctions (HP:0005244)4.04883835
19Panhypogammaglobulinemia (HP:0003139)3.98481368
20Recurrent skin infections (HP:0001581)3.83003722
21Meningitis (HP:0001287)3.78878408
22Encephalitis (HP:0002383)3.71748239
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.71737166
24Spontaneous hematomas (HP:0007420)3.69378364
25Vasculitis (HP:0002633)3.60526833
26Mediastinal lymphadenopathy (HP:0100721)3.58158842
27Recurrent bronchitis (HP:0002837)3.53357360
28Pustule (HP:0200039)3.47508277
29Leukocytosis (HP:0001974)3.39157819
30Autoimmune hemolytic anemia (HP:0001890)3.36253493
31Abnormality of macrophages (HP:0004311)3.34096062
32IgG deficiency (HP:0004315)3.28948961
33Keratoconjunctivitis sicca (HP:0001097)3.23760903
34Inflammation of the large intestine (HP:0002037)3.20036789
35Severe combined immunodeficiency (HP:0004430)3.19182589
36Recurrent gram-negative bacterial infections (HP:0005420)3.17631016
37Gingivitis (HP:0000230)3.13046726
38Colitis (HP:0002583)3.11850363
39Pulmonary infiltrates (HP:0002113)3.07938912
40Abnormality of eosinophils (HP:0001879)3.06922566
41Lymphopenia (HP:0001888)3.06617863
42Chest pain (HP:0100749)3.06083377
43Agammaglobulinemia (HP:0004432)3.05105342
44IgM deficiency (HP:0002850)3.05091969
45Eosinophilia (HP:0001880)3.04953024
46Gastrointestinal inflammation (HP:0004386)3.02163962
47Keratoconjunctivitis (HP:0001096)3.01320412
48Granulocytopenia (HP:0001913)3.00030630
49Gingival bleeding (HP:0000225)2.97860536
50Hemoptysis (HP:0002105)2.92629251
51Chronic obstructive pulmonary disease (HP:0006510)2.91922398
52Obstructive lung disease (HP:0006536)2.91922398
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.91771849
54Abnormality of T cell physiology (HP:0011840)2.90940627
55Prolonged bleeding time (HP:0003010)2.89926176
56Arterial thrombosis (HP:0004420)2.80971347
57Chronic diarrhea (HP:0002028)2.73973418
58Epistaxis (HP:0000421)2.72007864
59Hypoplasia of the thymus (HP:0000778)2.67359710
60Verrucae (HP:0200043)2.66855887
61Papilloma (HP:0012740)2.66855887
62IgA deficiency (HP:0002720)2.63575843
63Increased IgM level (HP:0003496)2.63023841
64Papilledema (HP:0001085)2.61787832
65Thyroiditis (HP:0100646)2.55259781
66Slow saccadic eye movements (HP:0000514)2.55006273
67Viral hepatitis (HP:0006562)2.54233521
68Cellulitis (HP:0100658)2.53550407
69Pulmonary embolism (HP:0002204)2.49227187
70Abnormality of the fingertips (HP:0001211)2.47447041
71Urticaria (HP:0001025)2.46795183
72Combined immunodeficiency (HP:0005387)2.46602803
73Stomach cancer (HP:0012126)2.34426657
74Anorexia (HP:0002039)2.29349737
75Increased IgE level (HP:0003212)2.27492848
76Autoimmune thrombocytopenia (HP:0001973)2.27297202
77Acute hepatic failure (HP:0006554)2.21863409
78Osteomyelitis (HP:0002754)2.16762331
79Chronic otitis media (HP:0000389)2.16532308
80Hypochromic anemia (HP:0001931)2.15475319
81Abnormality of B cell number (HP:0010975)2.14809122
82Hematochezia (HP:0002573)2.14183499
83Gangrene (HP:0100758)2.11819141
84Subacute progressive viral hepatitis (HP:0006572)2.11817879
85Joint swelling (HP:0001386)2.08506422
86Lymphoma (HP:0002665)2.08496455
87Peritonitis (HP:0002586)2.05227631
88Gastrointestinal stroma tumor (HP:0100723)2.04422822
89Microcytic anemia (HP:0001935)2.04408218
90Abnormality of the pleura (HP:0002103)2.04200974
91Sepsis (HP:0100806)2.03929758
92Basal cell carcinoma (HP:0002671)2.03701566
93Hypochromic microcytic anemia (HP:0004840)1.99669180
94Abnormality of the prostate (HP:0008775)1.97668471
95Bronchitis (HP:0012387)1.97340055
96Hypergammaglobulinemia (HP:0010702)1.93921240
97Fatigue (HP:0012378)1.90081556
98Neoplasm of the tracheobronchial system (HP:0100552)1.89944619
99Hemiplegia (HP:0002301)1.89828719
100Amaurosis fugax (HP:0100576)1.88635545

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.35797068
2RIPK43.77625283
3TXK3.65334249
4TAOK32.83695472
5BLK2.77221467
6TYK22.63452546
7GRK62.50504863
8IKBKE2.45492331
9PRPF4B2.36089320
10FES2.35533399
11CSK2.28232204
12BTK2.26507840
13JAK32.23307487
14ITK2.17303023
15JAK12.13310127
16SYK2.11178361
17MAP3K142.09288060
18ZAP701.99014467
19IRAK41.90098449
20TEC1.88275323
21MAP3K131.79212204
22CAMKK21.72529916
23FGFR31.71521625
24MAP2K31.59767328
25HCK1.54904382
26MAP3K101.50048367
27LCK1.49446761
28NLK1.40967042
29FGR1.40958090
30LYN1.37717598
31FGFR41.37281075
32PIK3CG1.31582314
33BMPR21.26764299
34TNK21.16525232
35JAK21.15659190
36KIT1.14713874
37IKBKB1.13869815
38MARK31.12340572
39TBK11.09588839
40CAMKK11.05244164
41FRK0.99023518
42CSF1R0.98296905
43PIM10.94578502
44STK100.94369128
45PRKCQ0.93393216
46IRAK10.88945510
47EPHB10.87020553
48SGK20.86635959
49MARK20.83220267
50YES10.82728795
51WNK10.82061333
52PDK10.81636912
53MAP3K10.80398695
54STK40.76704848
55MAP3K20.73320379
56PTK2B0.73073686
57SGK30.71774327
58KSR20.70849385
59MAPK70.67945135
60CDK40.67034848
61LRRK20.65184858
62MAP3K30.64383479
63ERN10.62853090
64PASK0.61758066
65TRPM70.61161033
66MELK0.60997257
67SIK30.60650681
68TGFBR20.60461417
69HIPK20.60419912
70MAPK120.60198602
71MATK0.59004068
72CDK120.58842030
73MAP3K70.57944243
74MAPK110.54588875
75CDC42BPA0.54401486
76SIK20.53278364
77STK110.52806516
78TAOK10.51578309
79FYN0.51337180
80STK380.50593087
81NEK60.49697263
82GRK50.47441074
83ACVR1B0.47069715
84CDK60.46706586
85CHUK0.45620301
86RAF10.45282675
87IRAK20.44776880
88PRKCH0.42984708
89MAP3K110.41971844
90CAMK40.40722312
91RET0.40620216
92BRD40.39402421
93EGFR0.39126053
94GRK70.38220820
95SGK4940.37642835
96SGK2230.37642835
97TYRO30.32678748
98SGK10.32227602
99PDGFRB0.31992182
100TESK20.31719859

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.45825732
2Graft-versus-host disease_Homo sapiens_hsa053322.74557460
3T cell receptor signaling pathway_Homo sapiens_hsa046602.65266618
4B cell receptor signaling pathway_Homo sapiens_hsa046622.63446656
5Allograft rejection_Homo sapiens_hsa053302.62095899
6Leishmaniasis_Homo sapiens_hsa051402.58811541
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.58450089
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53309378
9Osteoclast differentiation_Homo sapiens_hsa043802.34863173
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26856599
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.19206150
12Measles_Homo sapiens_hsa051622.13426934
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.03027232
14Staphylococcus aureus infection_Homo sapiens_hsa051501.92273047
15Type I diabetes mellitus_Homo sapiens_hsa049401.86161582
16Antigen processing and presentation_Homo sapiens_hsa046121.85762229
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80741871
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79976372
19Hematopoietic cell lineage_Homo sapiens_hsa046401.77830906
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75158233
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72129528
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65523598
23Tuberculosis_Homo sapiens_hsa051521.65013295
24Acute myeloid leukemia_Homo sapiens_hsa052211.63205798
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.60955095
26Non-small cell lung cancer_Homo sapiens_hsa052231.58012273
27Asthma_Homo sapiens_hsa053101.53272641
28Viral myocarditis_Homo sapiens_hsa054161.50920255
29Influenza A_Homo sapiens_hsa051641.50432639
30Toxoplasmosis_Homo sapiens_hsa051451.49376813
31Chemokine signaling pathway_Homo sapiens_hsa040621.48887494
32Herpes simplex infection_Homo sapiens_hsa051681.47273077
33Hepatitis B_Homo sapiens_hsa051611.34870226
34TNF signaling pathway_Homo sapiens_hsa046681.31811717
35Malaria_Homo sapiens_hsa051441.31166130
36Platelet activation_Homo sapiens_hsa046111.24571366
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15483195
38Pancreatic cancer_Homo sapiens_hsa052121.09403558
39Hepatitis C_Homo sapiens_hsa051601.08373824
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07988468
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.05958103
42Prolactin signaling pathway_Homo sapiens_hsa049171.05253649
43Apoptosis_Homo sapiens_hsa042101.04363905
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01443648
45Legionellosis_Homo sapiens_hsa051341.01179446
46Dorso-ventral axis formation_Homo sapiens_hsa043200.99535936
47Chronic myeloid leukemia_Homo sapiens_hsa052200.95321844
48FoxO signaling pathway_Homo sapiens_hsa040680.94887751
49VEGF signaling pathway_Homo sapiens_hsa043700.94755798
50Renal cell carcinoma_Homo sapiens_hsa052110.87002879
51Inositol phosphate metabolism_Homo sapiens_hsa005620.86109222
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.86078572
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85247993
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83655550
55Epstein-Barr virus infection_Homo sapiens_hsa051690.81822948
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81476002
57Endometrial cancer_Homo sapiens_hsa052130.80381126
58mTOR signaling pathway_Homo sapiens_hsa041500.78433653
59Rheumatoid arthritis_Homo sapiens_hsa053230.77368505
60Viral carcinogenesis_Homo sapiens_hsa052030.76700149
61HTLV-I infection_Homo sapiens_hsa051660.76338703
62Colorectal cancer_Homo sapiens_hsa052100.75052661
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70357103
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69506829
65Choline metabolism in cancer_Homo sapiens_hsa052310.69388276
66African trypanosomiasis_Homo sapiens_hsa051430.66529544
67Phagosome_Homo sapiens_hsa041450.62726971
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.60664362
69Prostate cancer_Homo sapiens_hsa052150.59127902
70Shigellosis_Homo sapiens_hsa051310.58659187
71Pertussis_Homo sapiens_hsa051330.58322941
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.56495612
73MAPK signaling pathway_Homo sapiens_hsa040100.54120050
74ErbB signaling pathway_Homo sapiens_hsa040120.53832919
75Insulin resistance_Homo sapiens_hsa049310.53466015
76Glioma_Homo sapiens_hsa052140.50904530
77GnRH signaling pathway_Homo sapiens_hsa049120.50698560
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.49616170
79Long-term potentiation_Homo sapiens_hsa047200.49353842
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49342172
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48527816
82HIF-1 signaling pathway_Homo sapiens_hsa040660.48407437
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44711264
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43916067
85Notch signaling pathway_Homo sapiens_hsa043300.43790404
86Endocytosis_Homo sapiens_hsa041440.42925271
87Type II diabetes mellitus_Homo sapiens_hsa049300.39497405
88Other glycan degradation_Homo sapiens_hsa005110.38882685
89Ras signaling pathway_Homo sapiens_hsa040140.38380743
90Thyroid cancer_Homo sapiens_hsa052160.37968047
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36395383
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36326421
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36077869
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35267675
95Small cell lung cancer_Homo sapiens_hsa052220.33592735
96Cholinergic synapse_Homo sapiens_hsa047250.32851830
97Regulation of autophagy_Homo sapiens_hsa041400.32821442
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30906751
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30594615
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.30090867

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