ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.19662462
2	fucose catabolic process (GO:0019317)	4.39245908
3	L-fucose metabolic process (GO:0042354)	4.39245908
4	L-fucose catabolic process (GO:0042355)	4.39245908
5	tryptophan catabolic process (GO:0006569)	4.05289206
6	indole-containing compound catabolic process (GO:0042436)	4.05289206
7	indolalkylamine catabolic process (GO:0046218)	4.05289206
8	indolalkylamine metabolic process (GO:0006586)	4.04245919
9	response to pheromone (GO:0019236)	4.00267837
10	neural tube formation (GO:0001841)	3.92091559
11	DNA deamination (GO:0045006)	3.86719667
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.83082980
13	kynurenine metabolic process (GO:0070189)	3.82532656
14	tryptophan metabolic process (GO:0006568)	3.78097411
15	piRNA metabolic process (GO:0034587)	3.62496695
16	regulation of glucokinase activity (GO:0033131)	3.54664582
17	regulation of hexokinase activity (GO:1903299)	3.54664582
18	cellular ketone body metabolic process (GO:0046950)	3.54091070
19	signal peptide processing (GO:0006465)	3.42524491
20	platelet dense granule organization (GO:0060155)	3.40499287
21	protein K11-linked deubiquitination (GO:0035871)	3.39960388
22	detection of light stimulus involved in visual perception (GO:0050908)	3.32373197
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.32373197
24	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.29881446
25	ketone body metabolic process (GO:1902224)	3.28668355
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.15708108
27	dopamine transport (GO:0015872)	3.15640949
28	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07309863
29	regulation of mitotic spindle checkpoint (GO:1903504)	3.07309863
30	DNA methylation involved in gamete generation (GO:0043046)	3.06968659
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.05880564
32	kidney morphogenesis (GO:0060993)	3.03764979
33	axoneme assembly (GO:0035082)	2.99765088
34	indole-containing compound metabolic process (GO:0042430)	2.99013801
35	replication fork processing (GO:0031297)	2.97507264
36	behavioral response to ethanol (GO:0048149)	2.93886685
37	water-soluble vitamin biosynthetic process (GO:0042364)	2.93127856
38	negative regulation of mast cell activation (GO:0033004)	2.87618094
39	reflex (GO:0060004)	2.87595805
40	photoreceptor cell maintenance (GO:0045494)	2.87362533
41	cornea development in camera-type eye (GO:0061303)	2.87197179
42	amine catabolic process (GO:0009310)	2.87055724
43	cellular biogenic amine catabolic process (GO:0042402)	2.87055724
44	protein-cofactor linkage (GO:0018065)	2.86541624
45	prenylation (GO:0097354)	2.84458622
46	protein prenylation (GO:0018342)	2.84458622
47	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.81038597
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80871308
49	recombinational repair (GO:0000725)	2.79366959
50	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78645461
51	reciprocal DNA recombination (GO:0035825)	2.77495467
52	reciprocal meiotic recombination (GO:0007131)	2.77495467
53	double-strand break repair via homologous recombination (GO:0000724)	2.76817010
54	primary amino compound metabolic process (GO:1901160)	2.74883967
55	rRNA catabolic process (GO:0016075)	2.74812154
56	rhodopsin mediated signaling pathway (GO:0016056)	2.72175108
57	neuronal action potential (GO:0019228)	2.71622622
58	negative regulation of telomere maintenance (GO:0032205)	2.71050891
59	regulation of hippo signaling (GO:0035330)	2.70697741
60	synapsis (GO:0007129)	2.69036654
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.68342446
62	multicellular organism reproduction (GO:0032504)	2.67899107
63	gamma-aminobutyric acid transport (GO:0015812)	2.67511461
64	serotonin metabolic process (GO:0042428)	2.66435566
65	sulfation (GO:0051923)	2.65187564
66	L-methionine salvage (GO:0071267)	2.64889252
67	L-methionine biosynthetic process (GO:0071265)	2.64889252
68	amino acid salvage (GO:0043102)	2.64889252
69	cAMP catabolic process (GO:0006198)	2.64095252
70	epithelial cilium movement (GO:0003351)	2.63174170
71	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.62649238
72	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.61082344
73	retinal cone cell development (GO:0046549)	2.59541656
74	protein localization to cilium (GO:0061512)	2.58686516
75	mannosylation (GO:0097502)	2.58315438
76	respiratory chain complex IV assembly (GO:0008535)	2.56779703
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56474586
78	NADH dehydrogenase complex assembly (GO:0010257)	2.56474586
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56474586
80	protein complex biogenesis (GO:0070271)	2.54337228
81	regulation of neurotransmitter uptake (GO:0051580)	2.54313864
82	centriole replication (GO:0007099)	2.54197967
83	NAD biosynthetic process (GO:0009435)	2.51934527
84	DNA double-strand break processing (GO:0000729)	2.50831815
85	regulation of cilium movement (GO:0003352)	2.50388976
86	regulation of action potential (GO:0098900)	2.48473932
87	adaptation of signaling pathway (GO:0023058)	2.48141273
88	cytochrome complex assembly (GO:0017004)	2.47357685
89	methionine biosynthetic process (GO:0009086)	2.47066046
90	proline transport (GO:0015824)	2.47013869
91	mitochondrial respiratory chain complex assembly (GO:0033108)	2.46321312
92	positive regulation of defense response to virus by host (GO:0002230)	2.44978394
93	cilium morphogenesis (GO:0060271)	2.44709545
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.44553634
95	nonmotile primary cilium assembly (GO:0035058)	2.44374307
96	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.43673488
97	positive regulation of fatty acid transport (GO:2000193)	2.42892737
98	regulation of memory T cell differentiation (GO:0043380)	2.41479717
99	cilium or flagellum-dependent cell motility (GO:0001539)	2.40921177
100	glycerophospholipid catabolic process (GO:0046475)	2.39929507

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68136513
2	VDR_22108803_ChIP-Seq_LS180_Human	3.49042628
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.90662942
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72361504
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67700547
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64016244
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52940895
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.39989827
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33821844
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29217057
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25868749
12	EWS_26573619_Chip-Seq_HEK293_Human	2.20652987
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.20126196
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.16338333
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.13961786
16	P300_19829295_ChIP-Seq_ESCs_Human	2.12191994
17	FUS_26573619_Chip-Seq_HEK293_Human	2.09791794
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08536063
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.89301845
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88725988
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83272047
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79532662
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76244448
24	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.63050442
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.61014085
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60044815
27	STAT3_23295773_ChIP-Seq_U87_Human	1.59918619
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59492862
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59305088
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58636927
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58385582
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57481399
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53478611
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52965240
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50998374
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50191939
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50191939
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49180686
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.48787399
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.48787399
41	AR_25329375_ChIP-Seq_VCAP_Human	1.48601428
42	TCF4_23295773_ChIP-Seq_U87_Human	1.46915774
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.46258761
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43916013
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43916013
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43455721
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43333157
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.43020036
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41833363
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.41456916
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.40294649
52	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38506744
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38108339
54	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36169813
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.36164668
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34730025
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34730025
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29405254
59	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.29252455
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.27073493
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26015343
62	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.25921882
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.25720434
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25438798
65	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24813463
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24760520
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24159766
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22854406
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22273152
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21868054
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.21071385
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20252284
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19147040
74	P53_22387025_ChIP-Seq_ESCs_Mouse	1.19103816
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19052295
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18201729
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16629479
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14843941
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14107863
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.13209280
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.11908263
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11760570
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11685735
84	MYC_18940864_ChIP-ChIP_HL60_Human	1.11466617
85	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10638841
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08700349
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08488713
88	ELK1_19687146_ChIP-ChIP_HELA_Human	1.07334221
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07327868
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.07305337
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07285170
92	P300_18555785_Chip-Seq_ESCs_Mouse	1.05734749
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.03761799
94	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03660253
95	AR_20517297_ChIP-Seq_VCAP_Human	1.03117981
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02981226
97	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01680294
98	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01017860
99	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.01005838
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98093455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.03357515
2	MP0003195_calcinosis	3.14329213
3	MP0008877_abnormal_DNA_methylation	3.00400102
4	MP0002102_abnormal_ear_morphology	2.85686113
5	MP0005551_abnormal_eye_electrophysiolog	2.61824434
6	MP0004147_increased_porphyrin_level	2.55924544
7	MP0005645_abnormal_hypothalamus_physiol	2.46816063
8	MP0003787_abnormal_imprinting	2.32956738
9	MP0003136_yellow_coat_color	2.27347134
10	MP0003646_muscle_fatigue	2.26014382
11	MP0001968_abnormal_touch/_nociception	2.25379333
12	MP0002837_dystrophic_cardiac_calcinosis	2.23717506
13	MP0000372_irregular_coat_pigmentation	2.20999949
14	MP0002736_abnormal_nociception_after	2.20075231
15	MP0009046_muscle_twitch	1.97642447
16	MP0006072_abnormal_retinal_apoptosis	1.86511701
17	MP0005253_abnormal_eye_physiology	1.82980287
18	MP0008872_abnormal_physiological_respon	1.82284182
19	MP0000427_abnormal_hair_cycle	1.78958654
20	MP0004133_heterotaxia	1.74248402
21	MP0001986_abnormal_taste_sensitivity	1.71800262
22	MP0003011_delayed_dark_adaptation	1.71773146
23	MP0002876_abnormal_thyroid_physiology	1.70044755
24	MP0004885_abnormal_endolymph	1.69692434
25	MP0008875_abnormal_xenobiotic_pharmacok	1.67010256
26	MP0008995_early_reproductive_senescence	1.66571467
27	MP0002638_abnormal_pupillary_reflex	1.65782276
28	MP0001501_abnormal_sleep_pattern	1.63898994
29	MP0009745_abnormal_behavioral_response	1.62888546
30	MP0005174_abnormal_tail_pigmentation	1.58569126
31	MP0004043_abnormal_pH_regulation	1.53282330
32	MP0002938_white_spotting	1.51259907
33	MP0004142_abnormal_muscle_tone	1.50908215
34	MP0002272_abnormal_nervous_system	1.49103530
35	MP0001485_abnormal_pinna_reflex	1.47304581
36	MP0006292_abnormal_olfactory_placode	1.47127340
37	MP0001486_abnormal_startle_reflex	1.40223200
38	MP0003718_maternal_effect	1.40035452
39	MP0003880_abnormal_central_pattern	1.36864438
40	MP0002928_abnormal_bile_duct	1.35341164
41	MP0006276_abnormal_autonomic_nervous	1.34366509
42	MP0005646_abnormal_pituitary_gland	1.30520662
43	MP0003890_abnormal_embryonic-extraembry	1.25277266
44	MP0002735_abnormal_chemical_nociception	1.25107498
45	MP0005379_endocrine/exocrine_gland_phen	1.21141381
46	MP0004742_abnormal_vestibular_system	1.19739687
47	MP0002653_abnormal_ependyma_morphology	1.16623644
48	MP0008058_abnormal_DNA_repair	1.16397320
49	MP0010386_abnormal_urinary_bladder	1.14582712
50	MP0002163_abnormal_gland_morphology	1.14497312
51	MP0005084_abnormal_gallbladder_morpholo	1.13795414
52	MP0005075_abnormal_melanosome_morpholog	1.13678584
53	MP0001984_abnormal_olfaction	1.12327610
54	MP0002160_abnormal_reproductive_system	1.12225994
55	MP0005389_reproductive_system_phenotype	1.12091405
56	MP0001970_abnormal_pain_threshold	1.11580196
57	MP0008057_abnormal_DNA_replication	1.10778130
58	MP0001529_abnormal_vocalization	1.10622240
59	MP0002733_abnormal_thermal_nociception	1.09935865
60	MP0002572_abnormal_emotion/affect_behav	1.09550975
61	MP0002277_abnormal_respiratory_mucosa	1.09444148
62	MP0000631_abnormal_neuroendocrine_gland	1.06858901
63	MP0002095_abnormal_skin_pigmentation	1.06641075
64	MP0003252_abnormal_bile_duct	1.05850406
65	MP0002557_abnormal_social/conspecific_i	1.05595976
66	MP0002064_seizures	1.02570126
67	MP0003121_genomic_imprinting	1.01464797
68	MP0004924_abnormal_behavior	1.01324630
69	MP0005386_behavior/neurological_phenoty	1.01324630
70	MP0005377_hearing/vestibular/ear_phenot	1.01175562
71	MP0003878_abnormal_ear_physiology	1.01175562
72	MP0005410_abnormal_fertilization	1.00224770
73	MP0002067_abnormal_sensory_capabilities	1.00134269
74	MP0002693_abnormal_pancreas_physiology	0.99826785
75	MP0005167_abnormal_blood-brain_barrier	0.97256945
76	MP0002254_reproductive_system_inflammat	0.96878707
77	MP0005171_absent_coat_pigmentation	0.96466465
78	MP0004145_abnormal_muscle_electrophysio	0.95302741
79	MP0005085_abnormal_gallbladder_physiolo	0.93069685
80	MP0002138_abnormal_hepatobiliary_system	0.91246099
81	MP0003698_abnormal_male_reproductive	0.90513199
82	MP0000230_abnormal_systemic_arterial	0.88287664
83	MP0005195_abnormal_posterior_eye	0.87456889
84	MP0000383_abnormal_hair_follicle	0.87084646
85	MP0000647_abnormal_sebaceous_gland	0.85846114
86	MP0003786_premature_aging	0.85035497
87	MP0001919_abnormal_reproductive_system	0.84547443
88	MP0001905_abnormal_dopamine_level	0.83794369
89	MP0001929_abnormal_gametogenesis	0.83405171
90	MP0001764_abnormal_homeostasis	0.82171789
91	MP0002229_neurodegeneration	0.80594126
92	MP0006035_abnormal_mitochondrial_morpho	0.79708999
93	MP0002210_abnormal_sex_determination	0.77588216
94	MP0009764_decreased_sensitivity_to	0.74234763
95	MP0008775_abnormal_heart_ventricle	0.72732597
96	MP0004215_abnormal_myocardial_fiber	0.72258185
97	MP0001324_abnormal_eye_pigmentation	0.72132736
98	MP0002751_abnormal_autonomic_nervous	0.71060431
99	MP0005266_abnormal_metabolism	0.70410012
100	MP0008961_abnormal_basal_metabolism	0.69305870

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.52160579
2	Pancreatic fibrosis (HP:0100732)	4.16643221
3	True hermaphroditism (HP:0010459)	3.85608534
4	Abnormality of midbrain morphology (HP:0002418)	3.83909838
5	Molar tooth sign on MRI (HP:0002419)	3.83909838
6	Congenital stationary night blindness (HP:0007642)	3.80912189
7	Nephronophthisis (HP:0000090)	3.51464622
8	Attenuation of retinal blood vessels (HP:0007843)	3.47299870
9	Type II lissencephaly (HP:0007260)	3.39085282
10	Pendular nystagmus (HP:0012043)	3.32435716
11	Chronic hepatic failure (HP:0100626)	3.17191706
12	Abnormality of the renal medulla (HP:0100957)	3.12650797
13	Abnormal rod and cone electroretinograms (HP:0008323)	3.04236949
14	Abnormality of the renal cortex (HP:0011035)	2.98138656
15	Increased corneal curvature (HP:0100692)	2.94731549
16	Keratoconus (HP:0000563)	2.94731549
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90824545
18	Progressive inability to walk (HP:0002505)	2.89387929
19	Abolished electroretinogram (ERG) (HP:0000550)	2.85087138
20	Decreased central vision (HP:0007663)	2.84048621
21	Gaze-evoked nystagmus (HP:0000640)	2.83972963
22	Abnormality of alanine metabolism (HP:0010916)	2.81359520
23	Hyperalaninemia (HP:0003348)	2.81359520
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.81359520
25	Tubular atrophy (HP:0000092)	2.80747046
26	Hyperventilation (HP:0002883)	2.75321118
27	Cystic liver disease (HP:0006706)	2.72242045
28	Inability to walk (HP:0002540)	2.71266050
29	Medial flaring of the eyebrow (HP:0010747)	2.60286917
30	Stomach cancer (HP:0012126)	2.57350318
31	Intestinal atresia (HP:0011100)	2.52404198
32	Genetic anticipation (HP:0003743)	2.48666298
33	Cerebellar dysplasia (HP:0007033)	2.46789522
34	Lissencephaly (HP:0001339)	2.39707839
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36407386
36	Hypothermia (HP:0002045)	2.36079219
37	Abnormal drinking behavior (HP:0030082)	2.35034847
38	Polydipsia (HP:0001959)	2.35034847
39	Abnormality of the pons (HP:0007361)	2.27711057
40	Large for gestational age (HP:0001520)	2.26085898
41	Furrowed tongue (HP:0000221)	2.24924019
42	Anencephaly (HP:0002323)	2.23072279
43	Bony spicule pigmentary retinopathy (HP:0007737)	2.18407377
44	Hypoplasia of the pons (HP:0012110)	2.18021236
45	Broad-based gait (HP:0002136)	2.15776088
46	Sclerocornea (HP:0000647)	2.15413134
47	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14186776
48	Male pseudohermaphroditism (HP:0000037)	2.11750742
49	Progressive cerebellar ataxia (HP:0002073)	2.06803390
50	Renal cortical cysts (HP:0000803)	2.03936800
51	Congenital hepatic fibrosis (HP:0002612)	2.03646783
52	Fair hair (HP:0002286)	2.01084448
53	Decreased circulating renin level (HP:0003351)	1.98588569
54	Abnormal biliary tract physiology (HP:0012439)	1.97894275
55	Bile duct proliferation (HP:0001408)	1.97894275
56	Congenital, generalized hypertrichosis (HP:0004540)	1.97513709
57	Birth length less than 3rd percentile (HP:0003561)	1.93902206
58	Concave nail (HP:0001598)	1.93268984
59	Polyuria (HP:0000103)	1.92548358
60	Disproportionate short-trunk short stature (HP:0003521)	1.91766040
61	Gait imbalance (HP:0002141)	1.90532928
62	Focal motor seizures (HP:0011153)	1.90334564
63	Absent/shortened dynein arms (HP:0200106)	1.88868012
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88868012
65	Febrile seizures (HP:0002373)	1.88243874
66	Small hand (HP:0200055)	1.86561942
67	Congenital primary aphakia (HP:0007707)	1.86436034
68	Postaxial foot polydactyly (HP:0001830)	1.85718555
69	Hemiparesis (HP:0001269)	1.83831977
70	Colon cancer (HP:0003003)	1.83618013
71	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83612314
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.83257608
73	Genital tract atresia (HP:0001827)	1.83077702
74	Chorioretinal atrophy (HP:0000533)	1.82111330
75	Optic disc pallor (HP:0000543)	1.81325318
76	Constricted visual fields (HP:0001133)	1.81282805
77	Increased CSF lactate (HP:0002490)	1.78804691
78	3-Methylglutaconic aciduria (HP:0003535)	1.77878258
79	Bilateral microphthalmos (HP:0007633)	1.77873748
80	Patellar aplasia (HP:0006443)	1.77863893
81	Protruding tongue (HP:0010808)	1.77802786
82	Pachygyria (HP:0001302)	1.76034452
83	Clumsiness (HP:0002312)	1.74368437
84	Anterior segment dysgenesis (HP:0007700)	1.74118975
85	Methylmalonic acidemia (HP:0002912)	1.72516932
86	Widely spaced teeth (HP:0000687)	1.71257234
87	Agitation (HP:0000713)	1.71230454
88	Short tibia (HP:0005736)	1.70608710
89	Ketoacidosis (HP:0001993)	1.70454552
90	Nephrogenic diabetes insipidus (HP:0009806)	1.70236759
91	Dialeptic seizures (HP:0011146)	1.70145307
92	Congenital sensorineural hearing impairment (HP:0008527)	1.69272503
93	Optic nerve hypoplasia (HP:0000609)	1.68107745
94	Vaginal atresia (HP:0000148)	1.67773577
95	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67737980
96	Aplasia/Hypoplasia of the patella (HP:0006498)	1.66983638
97	Stomatitis (HP:0010280)	1.66197787
98	Dandy-Walker malformation (HP:0001305)	1.65932012
99	Abnormality of macular pigmentation (HP:0008002)	1.65506597
100	Sloping forehead (HP:0000340)	1.65405074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.40784403
2	ADRBK2	3.65455169
3	ACVR1B	2.96825518
4	ZAK	2.89526037
5	WNK3	2.89047316
6	BMPR1B	2.70745825
7	MAP4K2	2.69343254
8	INSRR	2.37164984
9	PINK1	2.36901794
10	GRK1	2.23202302
11	TAOK3	2.20287693
12	NUAK1	2.13068332
13	TLK1	1.88853566
14	CASK	1.87985142
15	MAPK13	1.83151059
16	TXK	1.65041132
17	MAP3K4	1.62040286
18	MKNK2	1.60571409
19	WNK4	1.58848288
20	OXSR1	1.55891761
21	PAK3	1.44708377
22	TRIM28	1.43709763
23	TNIK	1.35441964
24	STK38L	1.32023309
25	TAF1	1.28030072
26	ADRBK1	1.25957478
27	DAPK2	1.08770921
28	NLK	1.03251469
29	STK39	0.97814762
30	MKNK1	0.97444097
31	TEC	0.96591690
32	NTRK3	0.96381735
33	EIF2AK3	0.88637142
34	PTK2B	0.87180234
35	MST4	0.86833182
36	TGFBR1	0.85130876
37	PRKCE	0.84266980
38	PRKCG	0.83032831
39	PNCK	0.82407471
40	BCR	0.79066167
41	DYRK2	0.78898691
42	PLK2	0.76585583
43	VRK1	0.76158793
44	PIK3CA	0.73482892
45	MARK1	0.73357989
46	CAMKK2	0.73108409
47	MAP2K7	0.71725337
48	STK3	0.68396173
49	IKBKB	0.67576942
50	PIK3CG	0.66991657
51	DYRK3	0.62370554
52	ITK	0.61591044
53	EPHA3	0.60286131
54	PLK3	0.59956719
55	IRAK1	0.59471699
56	BRSK2	0.59184114
57	CHUK	0.58656153
58	CSNK1G1	0.58070611
59	MAP2K6	0.57708371
60	RPS6KA5	0.55298586
61	PKN1	0.54785957
62	PASK	0.54579009
63	STK11	0.54042187
64	MAPKAPK3	0.53392026
65	MAP4K1	0.52655034
66	PRKCQ	0.52411157
67	VRK2	0.50116890
68	MAPKAPK5	0.49126258
69	FGFR2	0.47152197
70	CSNK1G2	0.46802077
71	CAMK2A	0.46319096
72	BMPR2	0.45904835
73	KIT	0.44994840
74	ERBB3	0.42958434
75	TNK2	0.42506888
76	SYK	0.42018375
77	PRKAA2	0.41408577
78	PLK4	0.39756804
79	PRKACA	0.39609270
80	CAMK1	0.39418487
81	CSNK1G3	0.39002904
82	NME1	0.38792920
83	CDK3	0.38455606
84	GRK6	0.38445217
85	MARK3	0.38091607
86	CSNK1D	0.37517243
87	GRK7	0.36807857
88	WEE1	0.35496660
89	GRK5	0.34525792
90	SGK2	0.34396850
91	DYRK1A	0.33699295
92	CDC7	0.33062063
93	CHEK2	0.31690716
94	PLK1	0.30781699
95	PHKG1	0.29417086
96	PHKG2	0.29417086
97	NTRK2	0.28270352
98	CSNK1A1L	0.27388550
99	CSNK1A1	0.27088756
100	PRKCA	0.26334326

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.05453041
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.59586160
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.50382470
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.39409609
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39227080
6	Butanoate metabolism_Homo sapiens_hsa00650	2.36562483
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.36025001
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.31024658
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.30911888
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30829030
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.29560025
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.26419470
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24015939
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15515714
15	Homologous recombination_Homo sapiens_hsa03440	2.07345251
16	Caffeine metabolism_Homo sapiens_hsa00232	2.00843094
17	Nicotine addiction_Homo sapiens_hsa05033	1.92844693
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85104951
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.80683066
20	Olfactory transduction_Homo sapiens_hsa04740	1.79221038
21	Basal transcription factors_Homo sapiens_hsa03022	1.75930876
22	RNA polymerase_Homo sapiens_hsa03020	1.72854029
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.68335253
24	Protein export_Homo sapiens_hsa03060	1.66617049
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.63857775
26	ABC transporters_Homo sapiens_hsa02010	1.62694652
27	Taste transduction_Homo sapiens_hsa04742	1.57260513
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.46492525
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44886788
30	RNA degradation_Homo sapiens_hsa03018	1.40247101
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28438430
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26006302
33	Morphine addiction_Homo sapiens_hsa05032	1.25913768
34	One carbon pool by folate_Homo sapiens_hsa00670	1.17487998
35	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15953807
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.13777338
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10345989
38	Parkinsons disease_Homo sapiens_hsa05012	1.08626756
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07459289
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03711418
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02834536
42	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98978977
43	Serotonergic synapse_Homo sapiens_hsa04726	0.96765314
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.96433204
45	Peroxisome_Homo sapiens_hsa04146	0.95624015
46	Propanoate metabolism_Homo sapiens_hsa00640	0.91306239
47	Retinol metabolism_Homo sapiens_hsa00830	0.91268263
48	Glutamatergic synapse_Homo sapiens_hsa04724	0.88626969
49	Insulin secretion_Homo sapiens_hsa04911	0.88016291
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.86109820
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.86031697
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.84762384
53	Circadian entrainment_Homo sapiens_hsa04713	0.81323951
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.80151692
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78543430
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75948040
57	Huntingtons disease_Homo sapiens_hsa05016	0.75794725
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75761272
59	Purine metabolism_Homo sapiens_hsa00230	0.75637550
60	GABAergic synapse_Homo sapiens_hsa04727	0.75366703
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69862115
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.69020133
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.68869354
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.66465449
65	Alzheimers disease_Homo sapiens_hsa05010	0.66341773
66	Mineral absorption_Homo sapiens_hsa04978	0.64406542
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62994361
68	Salivary secretion_Homo sapiens_hsa04970	0.62063417
69	Regulation of autophagy_Homo sapiens_hsa04140	0.62022860
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60070482
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58743214
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57507514
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55734937
74	Long-term depression_Homo sapiens_hsa04730	0.55672473
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54961130
76	Metabolic pathways_Homo sapiens_hsa01100	0.54483332
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52505457
78	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51070234
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50943782
80	Asthma_Homo sapiens_hsa05310	0.49628941
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.48778016
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48490194
83	Cardiac muscle contraction_Homo sapiens_hsa04260	0.47061324
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47028131
85	Sulfur relay system_Homo sapiens_hsa04122	0.46646686
86	Lysine degradation_Homo sapiens_hsa00310	0.43218462
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41850279
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40792377
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40601685
90	Histidine metabolism_Homo sapiens_hsa00340	0.40402923
91	Circadian rhythm_Homo sapiens_hsa04710	0.40178777
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37945872
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37576836
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33472818
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32426207
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.31269689
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.30437333
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30383694
99	Amphetamine addiction_Homo sapiens_hsa05031	0.27219528
100	Allograft rejection_Homo sapiens_hsa05330	0.22059679

GVQW1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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