GXYLT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GXYLT1 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)4.85187193
2meiotic chromosome segregation (GO:0045132)4.48459852
3mitotic sister chromatid cohesion (GO:0007064)4.21790573
4regulation of centriole replication (GO:0046599)4.19983112
5central nervous system myelination (GO:0022010)4.13393145
6axon ensheathment in central nervous system (GO:0032291)4.13393145
7DNA unwinding involved in DNA replication (GO:0006268)3.88470778
8double-strand break repair via nonhomologous end joining (GO:0006303)3.86832827
9non-recombinational repair (GO:0000726)3.86832827
10lateral sprouting from an epithelium (GO:0060601)3.83965282
11CENP-A containing nucleosome assembly (GO:0034080)3.77420093
12chromatin remodeling at centromere (GO:0031055)3.76544886
13mitotic sister chromatid segregation (GO:0000070)3.75904539
14sister chromatid cohesion (GO:0007062)3.71497970
15cytoplasmic mRNA processing body assembly (GO:0033962)3.70767098
16regulation of centrosome cycle (GO:0046605)3.59534694
17DNA strand elongation involved in DNA replication (GO:0006271)3.53482311
18regulation of centrosome duplication (GO:0010824)3.53189473
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47701960
20monoubiquitinated protein deubiquitination (GO:0035520)3.44051241
21pre-miRNA processing (GO:0031054)3.38682746
22histone exchange (GO:0043486)3.38145760
23DNA strand elongation (GO:0022616)3.36502377
24paraxial mesoderm development (GO:0048339)3.36071723
25protein localization to kinetochore (GO:0034501)3.35964989
26DNA replication checkpoint (GO:0000076)3.33683093
27spindle assembly involved in mitosis (GO:0090307)3.30782506
28mesodermal cell differentiation (GO:0048333)3.30673482
29ensheathment of neurons (GO:0007272)3.30316724
30axon ensheathment (GO:0008366)3.30316724
31protein localization to chromosome, centromeric region (GO:0071459)3.27522189
32metaphase plate congression (GO:0051310)3.22565002
33myelination (GO:0042552)3.22087047
34response to X-ray (GO:0010165)3.21515506
35negative regulation of mRNA metabolic process (GO:1903312)3.20715814
36regulation of transforming growth factor beta2 production (GO:0032909)3.20198183
37DNA ligation (GO:0006266)3.19743511
38mitotic recombination (GO:0006312)3.18732037
39negative regulation of mRNA processing (GO:0050686)3.17886806
40telomere maintenance via recombination (GO:0000722)3.14849939
41DNA synthesis involved in DNA repair (GO:0000731)3.14678807
42telomere maintenance via semi-conservative replication (GO:0032201)3.14581972
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11923152
44asymmetric protein localization (GO:0008105)3.08410048
45apical protein localization (GO:0045176)3.04445995
46heterochromatin organization (GO:0070828)3.02413560
47somatic diversification of immune receptors via somatic mutation (GO:0002566)2.99836436
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.99836436
49mitotic metaphase plate congression (GO:0007080)2.96666539
50regulation of RNA export from nucleus (GO:0046831)2.96389322
51histone H3-K4 trimethylation (GO:0080182)2.93212184
52microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.93196978
53DNA replication-independent nucleosome assembly (GO:0006336)2.91642796
54DNA replication-independent nucleosome organization (GO:0034724)2.91642796
55chromosome condensation (GO:0030261)2.89525875
56protein localization to endosome (GO:0036010)2.86457525
57establishment of chromosome localization (GO:0051303)2.86253012
58establishment of integrated proviral latency (GO:0075713)2.84896580
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.83213811
60NLS-bearing protein import into nucleus (GO:0006607)2.82192360
61embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82063531
62DNA replication-dependent nucleosome assembly (GO:0006335)2.81813658
63DNA replication-dependent nucleosome organization (GO:0034723)2.81813658
64DNA replication initiation (GO:0006270)2.81386590
65glomerular filtration (GO:0003094)2.80970387
66bone trabecula formation (GO:0060346)2.80461924
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80401861
68head development (GO:0060322)2.79680155
69DNA duplex unwinding (GO:0032508)2.78543528
70DNA geometric change (GO:0032392)2.76849766
71negative regulation of neurotransmitter secretion (GO:0046929)2.76630367
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.76328212
73positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73696888
74regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73696888
75anterior/posterior axis specification, embryo (GO:0008595)2.71873232
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71614019
77DNA packaging (GO:0006323)2.70398498
78synapsis (GO:0007129)2.69053701
79ribosome assembly (GO:0042255)2.68744646
80renal filtration (GO:0097205)2.68263954
81enteric nervous system development (GO:0048484)2.68070666
82regulation of sister chromatid cohesion (GO:0007063)2.67942927
83dorsal/ventral axis specification (GO:0009950)2.67361772
84kinetochore assembly (GO:0051382)2.67186795
85regulation of DNA endoreduplication (GO:0032875)2.67055517
86chondrocyte development (GO:0002063)2.66989484
87protein K6-linked ubiquitination (GO:0085020)2.66776276
88positive regulation of actin filament depolymerization (GO:0030836)2.66032435
89DNA conformation change (GO:0071103)2.65093306
90mitotic G2/M transition checkpoint (GO:0044818)2.64692532
91fatty acid elongation (GO:0030497)2.64119595
92mitotic nuclear envelope disassembly (GO:0007077)2.63804520
93DNA topological change (GO:0006265)2.63532220
94ATP-dependent chromatin remodeling (GO:0043044)2.63405932
95regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.61829904
96histone-serine phosphorylation (GO:0035404)2.61141507
97retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61115659
98somatic recombination of immunoglobulin gene segments (GO:0016447)2.61024130
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60187805
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60187805
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.60187805
102regulation of mRNA 3-end processing (GO:0031440)2.60070116
103hippo signaling (GO:0035329)2.59217757
104embryonic foregut morphogenesis (GO:0048617)2.57419452
105kinetochore organization (GO:0051383)2.56722891
106nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.56568881
107positive regulation of chromosome segregation (GO:0051984)2.55295120
108negative regulation of axon extension involved in axon guidance (GO:0048843)2.54387693
109regulation of chromosome segregation (GO:0051983)2.54191541
110DNA strand renaturation (GO:0000733)2.52751184
111positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52006961
112regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52006961
113regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.51438855
114chromosome segregation (GO:0007059)2.49303161
115positive regulation of mRNA 3-end processing (GO:0031442)2.48255968
116notochord development (GO:0030903)2.47764737
117mesenchymal cell proliferation (GO:0010463)2.47731442
118pore complex assembly (GO:0046931)2.47096179
119membrane disassembly (GO:0030397)2.46787308
120nuclear envelope disassembly (GO:0051081)2.46787308
121positive regulation of osteoblast proliferation (GO:0033690)2.46711986
122activated T cell proliferation (GO:0050798)2.46011618
123mesenchymal cell differentiation (GO:0048762)2.44493765
124female gonad development (GO:0008585)2.43973415
125leukocyte migration involved in inflammatory response (GO:0002523)2.43701944
126nuclear pore complex assembly (GO:0051292)2.43392940
127regulation of establishment of cell polarity (GO:2000114)2.42754211
128spindle assembly (GO:0051225)2.42087501
129cortical actin cytoskeleton organization (GO:0030866)2.41911533
130regulation of hippo signaling (GO:0035330)2.41706416
131limb bud formation (GO:0060174)2.40368252
132somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39865027
133isotype switching (GO:0045190)2.39865027
134axis elongation (GO:0003401)2.39421940
135regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37878900
136ER overload response (GO:0006983)2.36923232
137histone H2B ubiquitination (GO:0033523)2.36627000
138prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.35628345
139long-chain fatty acid biosynthetic process (GO:0042759)2.35597917
140embryonic camera-type eye morphogenesis (GO:0048596)2.35546280
141establishment of mitotic spindle localization (GO:0040001)2.35072571
142virion attachment to host cell (GO:0019062)2.34443984
143adhesion of symbiont to host cell (GO:0044650)2.34443984
144cell proliferation involved in kidney development (GO:0072111)2.33992315
145endocardial cushion development (GO:0003197)2.30949249
146cranial suture morphogenesis (GO:0060363)2.30290752
147heterotypic cell-cell adhesion (GO:0034113)2.28397837
148cell fate commitment involved in formation of primary germ layer (GO:0060795)2.27747694
149negative regulation of axon guidance (GO:1902668)2.27133586
150negative regulation of JUN kinase activity (GO:0043508)2.26652476
151platelet-derived growth factor receptor signaling pathway (GO:0048008)2.26420767
152regulation of nucleobase-containing compound transport (GO:0032239)2.26379882
153regulation of osteoblast proliferation (GO:0033688)2.25793805
154establishment of mitotic spindle orientation (GO:0000132)2.25412130
155myelin maintenance (GO:0043217)2.25179649
156polarized epithelial cell differentiation (GO:0030859)2.23964842
157sister chromatid segregation (GO:0000819)2.23747711
158negative regulation of translation, ncRNA-mediated (GO:0040033)2.23631340
159regulation of translation, ncRNA-mediated (GO:0045974)2.23631340
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.23631340
161positive regulation of catenin import into nucleus (GO:0035413)2.23237130
162face morphogenesis (GO:0060325)2.22408030
163positive regulation of histone H3-K4 methylation (GO:0051571)2.21153100
164mesenchymal-epithelial cell signaling (GO:0060638)2.20890258
165response to lipoprotein particle (GO:0055094)2.20864594
166membrane raft organization (GO:0031579)2.20783122
167radial glial cell differentiation (GO:0060019)2.20476807
168oligodendrocyte differentiation (GO:0048709)2.19491455
169branching involved in prostate gland morphogenesis (GO:0060442)2.18633207
170membrane protein ectodomain proteolysis (GO:0006509)2.18482055
171embryonic forelimb morphogenesis (GO:0035115)2.17774892
172cortical cytoskeleton organization (GO:0030865)2.17736643
173negative regulation of DNA repair (GO:0045738)2.16214936
174embryonic cranial skeleton morphogenesis (GO:0048701)2.14974208
175mitotic chromosome condensation (GO:0007076)2.14283292
176regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13864315
177trophoblast giant cell differentiation (GO:0060707)2.13284402
178cell adhesion mediated by integrin (GO:0033627)2.11823577
179branch elongation of an epithelium (GO:0060602)2.10975669
180import into cell (GO:0098657)2.09920679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.11448757
2E2F7_22180533_ChIP-Seq_HELA_Human3.55482088
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.35475717
4* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.25756502
5WT1_19549856_ChIP-ChIP_CCG9911_Human3.11689632
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.00348984
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.00099030
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.83685725
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46987068
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.33422532
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.29478493
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27734283
13ELK1_19687146_ChIP-ChIP_HELA_Human2.20782607
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.20723571
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.15189041
16FUS_26573619_Chip-Seq_HEK293_Human2.11157945
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11136587
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05598206
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04004301
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.02327959
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00874184
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98988233
23TP53_16413492_ChIP-PET_HCT116_Human1.88228141
24EWS_26573619_Chip-Seq_HEK293_Human1.87988239
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86663571
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83013932
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75165244
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73375490
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.72532641
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72528136
31AR_21909140_ChIP-Seq_LNCAP_Human1.68870943
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68315687
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.65584496
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61993396
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59500499
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57518462
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53871500
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52947423
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51365945
40CJUN_26792858_Chip-Seq_BT549_Human1.50922936
41FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50306477
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49744253
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49744253
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49744253
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49141365
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46345535
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.44968399
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42583733
49BRD4_25478319_ChIP-Seq_HGPS_Human1.42484129
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41524596
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40377520
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37702658
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37002859
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35334616
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.34241617
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33560491
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33506905
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.32876168
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31993857
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31875137
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.30980627
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30004784
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29190962
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29190962
65IGF1R_20145208_ChIP-Seq_DFB_Human1.27992642
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27702431
67AHR_22903824_ChIP-Seq_MCF-7_Human1.27608769
68* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27553300
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27283050
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.26035946
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25755093
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25642568
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25583162
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25461411
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24940980
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.24654678
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.20670940
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18817244
79ER_23166858_ChIP-Seq_MCF-7_Human1.18530351
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18042650
81ZNF274_21170338_ChIP-Seq_K562_Hela1.16675057
82VDR_24787735_ChIP-Seq_THP-1_Human1.16578021
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.16240758
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.15474069
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15419494
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15419494
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15284855
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14222286
89* TAF15_26573619_Chip-Seq_HEK293_Human1.14217161
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13872073
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13493313
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13418442
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13072229
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11703048
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11546176
96MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11358208
97TP53_18474530_ChIP-ChIP_U2OS_Human1.11348277
98* IRF8_27001747_Chip-Seq_BMDM_Mouse1.10801801
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09410486
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08654091
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.08548616
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.08287107
103VDR_22108803_ChIP-Seq_LS180_Human1.07716134
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07457407
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06404496
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05669768
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.04503967
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03784546
109* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02346403
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01371386
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01040517
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00906991
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00052445
114FOXP3_21729870_ChIP-Seq_TREG_Human0.99189806
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99023441
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.98494914
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.98420428
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98386504
119TP63_23658742_ChIP-Seq_EP156T_Human0.96706599
120* TBL1_22424771_ChIP-Seq_293T_Human0.95266455
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95055389
122DCP1A_22483619_ChIP-Seq_HELA_Human0.94927154
123* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94647141
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94016999
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.93976804
126CDX2_22108803_ChIP-Seq_LS180_Human0.93217789
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93216462
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92923613
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92922672
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92593122
131TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92260832
132P300_19829295_ChIP-Seq_ESCs_Human0.91519522
133STAT3_23295773_ChIP-Seq_U87_Human0.91516824
134HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91422864
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91341595
136RUNX_20019798_ChIP-Seq_JUKART_Human0.91147120
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.90852538
138CBP_20019798_ChIP-Seq_JUKART_Human0.90620560
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90620560
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90450903
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89587604
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89471859
143GF1B_26923725_Chip-Seq_HPCs_Mouse0.89471858
144IRF8_21731497_ChIP-ChIP_J774_Mouse0.88526191
145SOX2_20726797_ChIP-Seq_SW620_Human0.88043890
146VDR_23849224_ChIP-Seq_CD4+_Human0.87758900
147CHD1_26751641_Chip-Seq_LNCaP_Human0.87629921
148PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87507792
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87482731
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86774558
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86280753
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85293331
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83905257
154MYC_18940864_ChIP-ChIP_HL60_Human0.83212637
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.82568954
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.82437705
157KDM5A_27292631_Chip-Seq_BREAST_Human0.82076095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.31468304
2MP0008438_abnormal_cutaneous_collagen2.84570588
3MP0008057_abnormal_DNA_replication2.75858386
4MP0009697_abnormal_copulation2.60387477
5MP0004272_abnormal_basement_membrane2.54557054
6MP0004957_abnormal_blastocyst_morpholog2.51543312
7MP0003111_abnormal_nucleus_morphology2.49536231
8MP0000383_abnormal_hair_follicle2.27826990
9MP0003950_abnormal_plasma_membrane2.24325220
10MP0003693_abnormal_embryo_hatching2.21525646
11MP0003937_abnormal_limbs/digits/tail_de2.19048334
12MP0010678_abnormal_skin_adnexa2.07104211
13MP0008058_abnormal_DNA_repair2.02581323
14MP0000920_abnormal_myelination2.02090582
15MP0003077_abnormal_cell_cycle2.01081737
16MP0009053_abnormal_anal_canal1.92226021
17MP0005623_abnormal_meninges_morphology1.90833815
18MP0002877_abnormal_melanocyte_morpholog1.89835697
19MP0000566_synostosis1.88661895
20MP0010368_abnormal_lymphatic_system1.84725460
21MP0001851_eye_inflammation1.82748301
22MP0003121_genomic_imprinting1.77088662
23MP0000569_abnormal_digit_pigmentation1.76541942
24MP0003385_abnormal_body_wall1.75196573
25MP0001299_abnormal_eye_distance/1.72636595
26MP0005171_absent_coat_pigmentation1.72375480
27MP0004185_abnormal_adipocyte_glucose1.72242004
28MP0003755_abnormal_palate_morphology1.70388386
29MP0005076_abnormal_cell_differentiation1.69722333
30MP0001346_abnormal_lacrimal_gland1.69420399
31MP0009384_cardiac_valve_regurgitation1.67969793
32MP0003705_abnormal_hypodermis_morpholog1.66156243
33MP0010307_abnormal_tumor_latency1.62863236
34MP0009250_abnormal_appendicular_skeleto1.61672154
35MP0006054_spinal_hemorrhage1.58605879
36MP0005503_abnormal_tendon_morphology1.56702231
37MP0002009_preneoplasia1.56316218
38MP0000733_abnormal_muscle_development1.55758622
39MP0000647_abnormal_sebaceous_gland1.54236012
40MP0010234_abnormal_vibrissa_follicle1.50776074
41MP0002938_white_spotting1.49869856
42MP0000432_abnormal_head_morphology1.45774004
43MP0000762_abnormal_tongue_morphology1.45643805
44MP0001293_anophthalmia1.43705009
45MP0005408_hypopigmentation1.43682262
46MP0003941_abnormal_skin_development1.43651224
47MP0001730_embryonic_growth_arrest1.41503199
48MP0003453_abnormal_keratinocyte_physiol1.39774732
49MP0000428_abnormal_craniofacial_morphol1.38763913
50MP0008007_abnormal_cellular_replicative1.37174247
51MP0010352_gastrointestinal_tract_polyps1.35581256
52MP0003943_abnormal_hepatobiliary_system1.34025235
53MP0004134_abnormal_chest_morphology1.33375284
54MP0005275_abnormal_skin_tensile1.32448411
55MP0003566_abnormal_cell_adhesion1.31978649
56MP0005409_darkened_coat_color1.30009046
57MP0005187_abnormal_penis_morphology1.29789411
58MP0010030_abnormal_orbit_morphology1.29678772
59MP0008877_abnormal_DNA_methylation1.29069336
60MP0001340_abnormal_eyelid_morphology1.28698716
61MP0003935_abnormal_craniofacial_develop1.28395475
62MP0003122_maternal_imprinting1.27446434
63MP0004233_abnormal_muscle_weight1.27055843
64MP0002177_abnormal_outer_ear1.26033842
65MP0002060_abnormal_skin_morphology1.25183362
66MP0002697_abnormal_eye_size1.24184780
67MP0009780_abnormal_chondrocyte_physiolo1.23330048
68MP0003091_abnormal_cell_migration1.23040880
69MP0000537_abnormal_urethra_morphology1.21349576
70MP0009703_decreased_birth_body1.20913162
71MP0004197_abnormal_fetal_growth/weight/1.18258011
72MP0000350_abnormal_cell_proliferation1.17681364
73MP0002932_abnormal_joint_morphology1.17666808
74MP0002092_abnormal_eye_morphology1.17569369
75MP0003690_abnormal_glial_cell1.16577913
76MP0009672_abnormal_birth_weight1.14998526
77MP0002396_abnormal_hematopoietic_system1.14778401
78MP0002160_abnormal_reproductive_system1.14151316
79MP0005023_abnormal_wound_healing1.13394825
80MP0000427_abnormal_hair_cycle1.12526927
81MP0006292_abnormal_olfactory_placode1.11404124
82MP0001915_intracranial_hemorrhage1.11131439
83MP0003315_abnormal_perineum_morphology1.10985564
84MP0003567_abnormal_fetal_cardiomyocyte1.10170568
85MP0000372_irregular_coat_pigmentation1.09813222
86MP0005257_abnormal_intraocular_pressure1.09298625
87MP0003283_abnormal_digestive_organ1.08019916
88MP0004381_abnormal_hair_follicle1.07563084
89MP0000462_abnormal_digestive_system1.07386364
90MP0002084_abnormal_developmental_patter1.06663606
91MP0004264_abnormal_extraembryonic_tissu1.06005077
92MP0002098_abnormal_vibrissa_morphology1.05845387
93MP0003942_abnormal_urinary_system1.03345386
94MP0002277_abnormal_respiratory_mucosa1.02885097
95MP0002109_abnormal_limb_morphology1.02793003
96MP0002925_abnormal_cardiovascular_devel1.02626140
97MP0001879_abnormal_lymphatic_vessel1.01908850
98MP0000516_abnormal_urinary_system1.01808801
99MP0005367_renal/urinary_system_phenotyp1.01808801
100MP0002116_abnormal_craniofacial_bone1.00029722
101MP0003787_abnormal_imprinting0.99824963
102MP0002085_abnormal_embryonic_tissue0.99537573
103MP0002080_prenatal_lethality0.99390269
104MP0005508_abnormal_skeleton_morphology0.99064938
105MP0003119_abnormal_digestive_system0.98666189
106MP0001661_extended_life_span0.96210409
107MP0000377_abnormal_hair_follicle0.94925012
108MP0003890_abnormal_embryonic-extraembry0.92413459
109MP0002111_abnormal_tail_morphology0.91098905
110MP0000767_abnormal_smooth_muscle0.90413452
111MP0002254_reproductive_system_inflammat0.89870553
112MP0008932_abnormal_embryonic_tissue0.89494810
113MP0000467_abnormal_esophagus_morphology0.89208557
114MP0002086_abnormal_extraembryonic_tissu0.88285636
115MP0003938_abnormal_ear_development0.88223318
116MP0003123_paternal_imprinting0.88017710
117MP0002933_joint_inflammation0.87764464
118MP0000049_abnormal_middle_ear0.87481272
119MP0005451_abnormal_body_composition0.87225258
120MP0002282_abnormal_trachea_morphology0.86696198
121MP0001286_abnormal_eye_development0.86293659
122MP0005380_embryogenesis_phenotype0.86158903
123MP0001672_abnormal_embryogenesis/_devel0.86158903
124MP0003828_pulmonary_edema0.85930202
125MP0002233_abnormal_nose_morphology0.85650101
126MP0003984_embryonic_growth_retardation0.85146758
127MP0002088_abnormal_embryonic_growth/wei0.84376146
128MP0001177_atelectasis0.83100389
129MP0003252_abnormal_bile_duct0.82878000
130MP0003300_gastrointestinal_ulcer0.82608651
131MP0001243_abnormal_dermal_layer0.81799956
132MP0001697_abnormal_embryo_size0.81073931
133MP0003786_premature_aging0.81032460
134MP0002113_abnormal_skeleton_development0.80742971
135MP0003936_abnormal_reproductive_system0.79623661
136MP0002090_abnormal_vision0.79602265
137MP0001145_abnormal_male_reproductive0.79545670
138MP0001216_abnormal_epidermal_layer0.79482545
139MP0004808_abnormal_hematopoietic_stem0.79281464
140MP0002210_abnormal_sex_determination0.78197525
141MP0001119_abnormal_female_reproductive0.77543241
142MP0000653_abnormal_sex_gland0.76639717
143MP0002234_abnormal_pharynx_morphology0.76612585
144MP0001929_abnormal_gametogenesis0.76332654
145MP0003195_calcinosis0.75937799
146MP0003115_abnormal_respiratory_system0.75708406

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00469641
2Chromsome breakage (HP:0040012)3.93733900
3Parakeratosis (HP:0001036)3.66915137
4Abnormality of chromosome stability (HP:0003220)3.41052952
5Volvulus (HP:0002580)3.34428384
6Short 4th metacarpal (HP:0010044)3.16676761
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16676761
8Meckel diverticulum (HP:0002245)3.15080044
9Premature rupture of membranes (HP:0001788)3.06902116
10Lip pit (HP:0100267)3.05537202
11Abnormality of the ileum (HP:0001549)2.99369915
12Abnormal foot bone ossification (HP:0010675)2.93616465
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.81531552
14Embryonal renal neoplasm (HP:0011794)2.80895693
15Coronal craniosynostosis (HP:0004440)2.70324460
16Abnormality of the nasal septum (HP:0000419)2.70305187
17Sensory axonal neuropathy (HP:0003390)2.62294146
18Asymmetry of the thorax (HP:0001555)2.61630229
19Missing ribs (HP:0000921)2.61462259
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60756847
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.60756847
22Shallow orbits (HP:0000586)2.59768839
23Abnormal tarsal ossification (HP:0008369)2.55777937
24Abnormality of the parietal bone (HP:0002696)2.51612463
25Abnormality of the preputium (HP:0100587)2.43656691
26Rhabdomyosarcoma (HP:0002859)2.40437351
27Ulnar bowing (HP:0003031)2.40345454
28Papillary thyroid carcinoma (HP:0002895)2.37548382
29Osteolytic defects of the hand bones (HP:0009699)2.35150307
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.35150307
31Disproportionate tall stature (HP:0001519)2.34257397
32Bifid tongue (HP:0010297)2.33201505
33Capillary hemangiomas (HP:0005306)2.32224893
34Absent eyebrow (HP:0002223)2.31682253
35Ectopic kidney (HP:0000086)2.29227395
36Cupped ear (HP:0000378)2.27093310
37Chin dimple (HP:0010751)2.25024233
38Abnormal lung lobation (HP:0002101)2.22631564
39Supernumerary ribs (HP:0005815)2.22395120
40Skull defect (HP:0001362)2.21730667
41Abnormality of the 4th metacarpal (HP:0010012)2.16737992
42Syringomyelia (HP:0003396)2.16082485
43Spinal cord lesions (HP:0100561)2.16082485
44Small intestinal stenosis (HP:0012848)2.15884089
45Duodenal stenosis (HP:0100867)2.15884089
46Pancreatic islet-cell hyperplasia (HP:0004510)2.14246042
47Colon cancer (HP:0003003)2.08998038
48Abnormal pancreas size (HP:0012094)2.08864937
49Curly hair (HP:0002212)2.08748470
50Absent radius (HP:0003974)2.07601800
51Arterial tortuosity (HP:0005116)2.07522894
52Abnormality of the carotid arteries (HP:0005344)2.06120878
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.05429231
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.04604167
55Disinhibition (HP:0000734)2.04310145
56Ependymoma (HP:0002888)2.03830475
57Small hand (HP:0200055)2.03406783
58Abnormality of the duodenum (HP:0002246)2.00415388
59Midline defect of the nose (HP:0004122)2.00112700
60Limited elbow extension (HP:0001377)1.98220849
61Absent forearm bone (HP:0003953)1.98157921
62Aplasia involving forearm bones (HP:0009822)1.98157921
63Sparse lateral eyebrow (HP:0005338)1.98148941
64Supernumerary bones of the axial skeleton (HP:0009144)1.97973448
65Hypoplastic labia majora (HP:0000059)1.96769309
66Abnormality of the fingertips (HP:0001211)1.96326322
67Neoplasm of the adrenal cortex (HP:0100641)1.96183128
68Abnormal umbilical cord blood vessels (HP:0011403)1.94669639
69Single umbilical artery (HP:0001195)1.94669639
70Abnormality of the fetal cardiovascular system (HP:0010948)1.94669639
71Myelodysplasia (HP:0002863)1.94240357
72Aortic dissection (HP:0002647)1.93876567
73Spontaneous abortion (HP:0005268)1.93726717
74Deviation of the thumb (HP:0009603)1.93658267
75Oligodontia (HP:0000677)1.93343063
76Infantile muscular hypotonia (HP:0008947)1.92158629
77Arteriovenous malformation (HP:0100026)1.91731968
78Broad thumb (HP:0011304)1.91700011
79Breast carcinoma (HP:0003002)1.90996061
80Aplasia cutis congenita (HP:0001057)1.89823264
81Abnormality of incisor morphology (HP:0011063)1.89349817
82Hypoplasia of the iris (HP:0007676)1.89229686
83Wormian bones (HP:0002645)1.89156786
84Thyroid carcinoma (HP:0002890)1.88558164
85Sloping forehead (HP:0000340)1.88541499
86Long eyelashes (HP:0000527)1.88420286
87Glioma (HP:0009733)1.86829219
88Cystic hygroma (HP:0000476)1.85786672
89Vascular tortuosity (HP:0004948)1.85646553
90Large earlobe (HP:0009748)1.85605234
91Cerebral aneurysm (HP:0004944)1.85555496
92Septate vagina (HP:0001153)1.84134084
93Hypopigmentation of the fundus (HP:0007894)1.83293457
94Soft skin (HP:0000977)1.83029300
95Myelomeningocele (HP:0002475)1.82949100
96Alacrima (HP:0000522)1.82699789
97Anteriorly placed anus (HP:0001545)1.81874950
98Clubbing of toes (HP:0100760)1.81390375
99Abnormality of the astrocytes (HP:0100707)1.81364396
100Astrocytoma (HP:0009592)1.81364396
101Hypolipoproteinemia (HP:0010981)1.81015328
102White forelock (HP:0002211)1.80992108
103Overlapping toe (HP:0001845)1.79980019
104Short middle phalanx of the 5th finger (HP:0004220)1.79624333
105Premature skin wrinkling (HP:0100678)1.79433445
106Abnormality of the labia majora (HP:0012881)1.78483646
107Small epiphyses (HP:0010585)1.76293852
108Short humerus (HP:0005792)1.75596377
109Ectropion (HP:0000656)1.75563969
110Acute myeloid leukemia (HP:0004808)1.74560175
111Gonadotropin excess (HP:0000837)1.74462702
112Hypobetalipoproteinemia (HP:0003563)1.74301855
113Proximal placement of thumb (HP:0009623)1.74235930
114Abnormality of the peritoneum (HP:0002585)1.73339570
115Adrenal hypoplasia (HP:0000835)1.73258446
116Aplasia/hypoplasia of the humerus (HP:0006507)1.73083669
117Aqueductal stenosis (HP:0002410)1.71967767
118Abnormality of the 2nd finger (HP:0004100)1.70422331
119Macroorchidism (HP:0000053)1.70109894
120Abnormality of the incisor (HP:0000676)1.68281037
121Cafe-au-lait spot (HP:0000957)1.68015050
122Deep philtrum (HP:0002002)1.67959755
123Microtia (HP:0008551)1.67551763
124Arnold-Chiari malformation (HP:0002308)1.64898493
125Widely spaced teeth (HP:0000687)1.62827148
126Abnormality of the pancreatic islet cells (HP:0006476)1.62571241
127Abnormality of endocrine pancreas physiology (HP:0012093)1.62571241
128Broad palm (HP:0001169)1.62545896
12911 pairs of ribs (HP:0000878)1.62466769
130Hypoalphalipoproteinemia (HP:0003233)1.62395581
131Scapular winging (HP:0003691)1.61845221
132Abnormality of chromosome segregation (HP:0002916)1.61631262
133Cerebellar dysplasia (HP:0007033)1.60868611
134Increased number of teeth (HP:0011069)1.60756941
135Gonadal dysgenesis (HP:0000133)1.60591225
136Depressed nasal tip (HP:0000437)1.59490089
137Hypoplasia of the maxilla (HP:0000327)1.59158146
138High anterior hairline (HP:0009890)1.59003941
139Triphalangeal thumb (HP:0001199)1.57889823
140Preaxial foot polydactyly (HP:0001841)1.57690611
141Skin pits (HP:0100276)1.57580064
142Abnormality of the phalanges of the hallux (HP:0010057)1.57483940
143Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.56625690
144Pulmonic stenosis (HP:0001642)1.56587599
145Relative macrocephaly (HP:0004482)1.56541851
146Gastrointestinal carcinoma (HP:0002672)1.56209669
147Malignant gastrointestinal tract tumors (HP:0006749)1.56209669
148Increased nuchal translucency (HP:0010880)1.56208677
149Transitional cell carcinoma of the bladder (HP:0006740)1.56146322
150Anal stenosis (HP:0002025)1.56133484
151Aortic aneurysm (HP:0004942)1.55498667
152Tibial bowing (HP:0002982)1.55158222
153Protrusio acetabuli (HP:0003179)1.54931520
154Cortical dysplasia (HP:0002539)1.54495748
155Neoplasm of the colon (HP:0100273)1.54468118
156Pseudobulbar signs (HP:0002200)1.54231640
157Abnormality of the nasolacrimal system (HP:0000614)1.54031103
158Hypoplastic pelvis (HP:0008839)1.53615504
159Abnormality of the renal collecting system (HP:0004742)1.53129319
160Unilateral renal agenesis (HP:0000122)1.53056374
161Atrophic scars (HP:0001075)1.53048246
162Ovarian neoplasm (HP:0100615)1.52327499
163Mitral valve prolapse (HP:0001634)1.51441077
164Esophageal atresia (HP:0002032)1.51248194
165Delayed cranial suture closure (HP:0000270)1.50535126
166Rectal fistula (HP:0100590)1.50148427
167Rectovaginal fistula (HP:0000143)1.50148427
168Nasolacrimal duct obstruction (HP:0000579)1.49424622
169Patchy hypopigmentation of hair (HP:0011365)1.49414699
170Neurofibrillary tangles (HP:0002185)1.49270348
171Abnormally folded helix (HP:0008544)1.48010500
172Submucous cleft hard palate (HP:0000176)1.47873413
173Nephroblastoma (Wilms tumor) (HP:0002667)1.47709599
174Prominent occiput (HP:0000269)1.47418929
175Preauricular pit (HP:0004467)1.46904492
176Periauricular skin pits (HP:0100277)1.46904492
177Abnormal auditory evoked potentials (HP:0006958)1.46869501
178Intestinal malrotation (HP:0002566)1.46520457
179Spondylolisthesis (HP:0003302)1.46261749
180Hematochezia (HP:0002573)1.44946635
181Vesicoureteral reflux (HP:0000076)1.44776778
182Bladder diverticulum (HP:0000015)1.44741923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.11364088
2LATS12.96362060
3WEE12.94765082
4STK392.87743022
5EIF2AK32.79299286
6ACVR1B2.45451715
7FGFR22.19325229
8TRPM72.09989560
9STK32.04465730
10AKT32.04291486
11TAF12.00207684
12STK101.90936239
13BRD41.81916039
14ICK1.78283187
15EPHB11.75327582
16STK38L1.73870551
17CDC71.71644172
18MET1.70430715
19TNIK1.70190715
20WNK11.68893786
21MKNK11.66216154
22PBK1.65221175
23MELK1.64947274
24BCR1.61023171
25CSNK1A1L1.60166602
26FRK1.60029162
27CDK61.53926366
28EIF2AK11.53443961
29SCYL21.50022463
30PDK21.46391311
31CLK11.43694709
32FLT31.41592908
33CSNK1G11.41268556
34PRKD31.39079435
35NUAK11.38621682
36PKN11.35812944
37TRIM281.35179710
38OXSR11.29410050
39PNCK1.29083716
40PKN21.28377500
41ATR1.27839911
42PLK11.26662479
43DDR21.26508242
44MAPK151.23762379
45ITK1.21452649
46CAMK1G1.21003467
47TIE11.17867253
48FER1.16208641
49NLK1.15011141
50CSNK1G31.14868595
51MKNK21.14833660
52LATS21.14015186
53PDGFRB1.11933639
54MST41.10389113
55VRK21.08521944
56PLK41.07819517
57ERBB41.07812703
58PAK21.07349561
59NEK61.07274004
60PTK61.06484325
61TSSK61.05541957
62BUB11.03500391
63CSK1.01715872
64ERBB31.01409297
65CAMK1D1.00985543
66FGR1.00924549
67TTN1.00684269
68TTK1.00250518
69MAPKAPK50.99581494
70PLK20.99080672
71YES10.97817307
72MAP3K100.96892672
73STK40.96334471
74ZAK0.94674893
75BMPR1B0.89985503
76NEK90.89497207
77BMPR20.89155698
78MTOR0.88639450
79SRPK10.88229216
80NEK20.88216919
81BMX0.87944258
82TGFBR20.84946325
83SIK10.83830663
84TAOK30.83059985
85LIMK10.81430369
86MARK30.81259052
87CDK70.79350084
88CSNK1G20.78578381
89RPS6KB20.78218095
90PLK30.77620043
91GSK3A0.76624733
92CSNK1D0.76594954
93AURKB0.76383857
94DMPK0.74642316
95ROCK20.74539238
96CDK90.73894740
97EIF2AK20.73885992
98TGFBR10.70279184
99ATM0.67893807
100CSF1R0.67052053
101NEK10.66106608
102CHEK10.64262606
103MAP3K140.63298369
104CDK30.63261774
105CHEK20.62923243
106RPS6KA40.62687871
107PIK3CA0.60017569
108PRKD10.58837657
109RPS6KA50.57996662
110UHMK10.57140422
111CDK80.56312985
112PDGFRA0.54810471
113CDK40.54028710
114VRK10.53982417
115INSR0.53936123
116RPS6KB10.53226104
117LRRK20.52935690
118FGFR10.52807251
119ERBB20.52254403
120PRKCQ0.52249542
121MAP4K10.52098947
122MAP3K80.51941315
123IRAK40.51876523
124EPHB20.51610814
125PTK20.49575830
126TYRO30.48701972
127BRSK20.47968696
128ALK0.47286482
129CDK10.47216876
130MAPK10.46849772
131CDK20.46423360
132ABL10.46133933
133WNK40.45571230
134MAPKAPK20.45183567
135MAP2K30.43975318
136SIK20.43790687
137PASK0.41762793
138CSNK1E0.41501910
139BRSK10.41049965
140MAP2K10.40824768
141MAP3K120.37350057
142STK240.35801178
143SIK30.34768363
144PRKCH0.34632392
145AKT20.34503713
146PRKDC0.34249716
147WNK30.34174622
148TEC0.33712437
149SGK20.31488044
150CSNK2A10.29709644

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.38101963
2Mismatch repair_Homo sapiens_hsa034303.22383949
3Nucleotide excision repair_Homo sapiens_hsa034202.31846201
4RNA transport_Homo sapiens_hsa030132.26101963
5Selenocompound metabolism_Homo sapiens_hsa004502.23014192
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19323821
7One carbon pool by folate_Homo sapiens_hsa006702.10580807
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10539796
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04343621
10Steroid biosynthesis_Homo sapiens_hsa001002.01219264
11ECM-receptor interaction_Homo sapiens_hsa045121.98407866
12MicroRNAs in cancer_Homo sapiens_hsa052061.86381078
13Basal cell carcinoma_Homo sapiens_hsa052171.83795380
14RNA degradation_Homo sapiens_hsa030181.81104727
15Base excision repair_Homo sapiens_hsa034101.76799576
16TGF-beta signaling pathway_Homo sapiens_hsa043501.71179505
17Prostate cancer_Homo sapiens_hsa052151.68780254
18Ether lipid metabolism_Homo sapiens_hsa005651.67976522
19Adherens junction_Homo sapiens_hsa045201.66616107
20Small cell lung cancer_Homo sapiens_hsa052221.65603597
21Hedgehog signaling pathway_Homo sapiens_hsa043401.60908320
22Spliceosome_Homo sapiens_hsa030401.58457230
23Sphingolipid metabolism_Homo sapiens_hsa006001.58054722
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54574539
25Proteoglycans in cancer_Homo sapiens_hsa052051.52041538
26Thyroid cancer_Homo sapiens_hsa052161.50695488
27Hippo signaling pathway_Homo sapiens_hsa043901.47429647
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42061375
29Axon guidance_Homo sapiens_hsa043601.41235738
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.40609097
31Renal cell carcinoma_Homo sapiens_hsa052111.39993264
32Propanoate metabolism_Homo sapiens_hsa006401.38713555
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37926388
34Focal adhesion_Homo sapiens_hsa045101.37416341
35Cell cycle_Homo sapiens_hsa041101.31778664
36Malaria_Homo sapiens_hsa051441.27898157
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27628476
38N-Glycan biosynthesis_Homo sapiens_hsa005101.25918439
39Wnt signaling pathway_Homo sapiens_hsa043101.25616001
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20005422
41RNA polymerase_Homo sapiens_hsa030201.18410027
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17088368
43Tight junction_Homo sapiens_hsa045301.16972445
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16228063
45Sulfur metabolism_Homo sapiens_hsa009201.15991747
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.14259869
47Hematopoietic cell lineage_Homo sapiens_hsa046401.14126618
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.13432984
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12761961
50Dorso-ventral axis formation_Homo sapiens_hsa043201.12615600
51Chronic myeloid leukemia_Homo sapiens_hsa052201.12334427
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11663204
53Lysine degradation_Homo sapiens_hsa003101.10634514
54Amoebiasis_Homo sapiens_hsa051461.08645867
55B cell receptor signaling pathway_Homo sapiens_hsa046621.08345054
56Pathways in cancer_Homo sapiens_hsa052001.07746788
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07370828
58Pancreatic cancer_Homo sapiens_hsa052121.07138164
59Pyrimidine metabolism_Homo sapiens_hsa002401.04158696
60Osteoclast differentiation_Homo sapiens_hsa043801.03878956
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02184160
62Non-homologous end-joining_Homo sapiens_hsa034501.01290544
63Ovarian steroidogenesis_Homo sapiens_hsa049131.00507585
64PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00294159
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00155323
66Viral carcinogenesis_Homo sapiens_hsa052030.97745994
67Linoleic acid metabolism_Homo sapiens_hsa005910.94446554
68Staphylococcus aureus infection_Homo sapiens_hsa051500.94210752
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93815037
70Viral myocarditis_Homo sapiens_hsa054160.93495296
71Fanconi anemia pathway_Homo sapiens_hsa034600.93416894
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91864919
73Butanoate metabolism_Homo sapiens_hsa006500.91248391
74Toxoplasmosis_Homo sapiens_hsa051450.91236351
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90513023
76Platelet activation_Homo sapiens_hsa046110.90492840
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.90158926
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88143454
79Homologous recombination_Homo sapiens_hsa034400.87722754
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86775569
81Melanoma_Homo sapiens_hsa052180.85810022
82mRNA surveillance pathway_Homo sapiens_hsa030150.84874727
83Autoimmune thyroid disease_Homo sapiens_hsa053200.83361936
84HTLV-I infection_Homo sapiens_hsa051660.83361800
85Basal transcription factors_Homo sapiens_hsa030220.83106748
86Colorectal cancer_Homo sapiens_hsa052100.81548049
87Vitamin digestion and absorption_Homo sapiens_hsa049770.81301978
88T cell receptor signaling pathway_Homo sapiens_hsa046600.81260821
89Histidine metabolism_Homo sapiens_hsa003400.80590219
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80404611
91Leishmaniasis_Homo sapiens_hsa051400.80177447
92Oocyte meiosis_Homo sapiens_hsa041140.79865634
93Hepatitis B_Homo sapiens_hsa051610.79437679
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.78230456
95Graft-versus-host disease_Homo sapiens_hsa053320.77856417
96Folate biosynthesis_Homo sapiens_hsa007900.76820353
97Circadian rhythm_Homo sapiens_hsa047100.74423976
98Notch signaling pathway_Homo sapiens_hsa043300.74090140
99Antigen processing and presentation_Homo sapiens_hsa046120.74014933
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72104736
101p53 signaling pathway_Homo sapiens_hsa041150.71988787
102Pyruvate metabolism_Homo sapiens_hsa006200.70697641
103Protein export_Homo sapiens_hsa030600.70306081
104Shigellosis_Homo sapiens_hsa051310.69856914
105TNF signaling pathway_Homo sapiens_hsa046680.68526310
106Pertussis_Homo sapiens_hsa051330.68286054
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67580931
108Fatty acid metabolism_Homo sapiens_hsa012120.67550407
109Herpes simplex infection_Homo sapiens_hsa051680.66773562
110MAPK signaling pathway_Homo sapiens_hsa040100.66742685
111Purine metabolism_Homo sapiens_hsa002300.66399277
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65266789
113ErbB signaling pathway_Homo sapiens_hsa040120.63332136
114Bladder cancer_Homo sapiens_hsa052190.63143591
115Measles_Homo sapiens_hsa051620.63122873
116Rap1 signaling pathway_Homo sapiens_hsa040150.63047507
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62533359
118Chemokine signaling pathway_Homo sapiens_hsa040620.61544815
119Phagosome_Homo sapiens_hsa041450.61319711
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60180464
121Proteasome_Homo sapiens_hsa030500.60110387
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59685700
123Choline metabolism in cancer_Homo sapiens_hsa052310.59379151
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.59291221
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58799999
126Ras signaling pathway_Homo sapiens_hsa040140.58200502
127FoxO signaling pathway_Homo sapiens_hsa040680.57906457
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57556454
129Hepatitis C_Homo sapiens_hsa051600.55633797
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54956842
131Arachidonic acid metabolism_Homo sapiens_hsa005900.54205680
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53209980
133Salmonella infection_Homo sapiens_hsa051320.52848113
134Thyroid hormone synthesis_Homo sapiens_hsa049180.52471439
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52358852
136Apoptosis_Homo sapiens_hsa042100.52115293
137Endocytosis_Homo sapiens_hsa041440.51796248
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.51659527
139Lysosome_Homo sapiens_hsa041420.51444116
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.50835939
141Endometrial cancer_Homo sapiens_hsa052130.49400185
142Fatty acid elongation_Homo sapiens_hsa000620.48891391
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.48077974
144Glutathione metabolism_Homo sapiens_hsa004800.46141842
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45401035
146Fatty acid degradation_Homo sapiens_hsa000710.44423042
147Caffeine metabolism_Homo sapiens_hsa002320.42614707
148Non-small cell lung cancer_Homo sapiens_hsa052230.41943239
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41723067
150Inositol phosphate metabolism_Homo sapiens_hsa005620.39188813
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38263041
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37903943
153Peroxisome_Homo sapiens_hsa041460.35812131
154Complement and coagulation cascades_Homo sapiens_hsa046100.34379714
155* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34256658
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33790674
157Glioma_Homo sapiens_hsa052140.29529889
158Glucagon signaling pathway_Homo sapiens_hsa049220.28916834
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28513331
160Retinol metabolism_Homo sapiens_hsa008300.25936519

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »