ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein polyglutamylation (GO:0018095)	8.67719259
2	sperm motility (GO:0030317)	8.53608755
3	protein targeting to Golgi (GO:0000042)	8.35970553
4	establishment of protein localization to Golgi (GO:0072600)	8.15222525
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.87237913
6	seminiferous tubule development (GO:0072520)	6.45019352
7	protein localization to Golgi apparatus (GO:0034067)	6.04454843
8	fusion of sperm to egg plasma membrane (GO:0007342)	5.74434960
9	acrosome reaction (GO:0007340)	5.49641625
10	single strand break repair (GO:0000012)	5.41703893
11	microtubule nucleation (GO:0007020)	5.28455866
12	microtubule polymerization or depolymerization (GO:0031109)	5.12043276
13	spermatid development (GO:0007286)	5.07064878
14	epithelial cilium movement (GO:0003351)	4.97715944
15	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.80893584
16	centriole replication (GO:0007099)	4.76523582
17	spermatogenesis (GO:0007283)	4.75733235
18	male gamete generation (GO:0048232)	4.73915237
19	cilium or flagellum-dependent cell motility (GO:0001539)	4.62490341
20	nuclear pore complex assembly (GO:0051292)	4.56881667
21	glomerular visceral epithelial cell development (GO:0072015)	4.51939529
22	sperm capacitation (GO:0048240)	4.49800812
23	plasma membrane fusion (GO:0045026)	4.46553773
24	regulation of centriole replication (GO:0046599)	4.40957878
25	gamete generation (GO:0007276)	4.40563195
26	microtubule depolymerization (GO:0007019)	4.40109226
27	calcium ion-dependent exocytosis (GO:0017156)	4.27619182
28	musculoskeletal movement (GO:0050881)	4.27267790
29	multicellular organismal movement (GO:0050879)	4.27267790
30	microtubule severing (GO:0051013)	4.26520660
31	cilium movement (GO:0003341)	4.22400253
32	axonemal dynein complex assembly (GO:0070286)	4.20529709
33	glomerular epithelial cell development (GO:0072310)	4.13076919
34	rRNA methylation (GO:0031167)	4.08743227
35	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.03458991
36	chromosome condensation (GO:0030261)	4.02445361
37	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.98498197
38	centriole assembly (GO:0098534)	3.96250129
39	DNA packaging (GO:0006323)	3.95700609
40	multicellular organism reproduction (GO:0032504)	3.92153824
41	phosphatidylethanolamine metabolic process (GO:0046337)	3.87251759
42	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.82083905
43	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.68875300
44	motile cilium assembly (GO:0044458)	3.65304565
45	neuron-neuron synaptic transmission (GO:0007270)	3.64822258
46	single fertilization (GO:0007338)	3.62049288
47	fertilization (GO:0009566)	3.59449699
48	sperm-egg recognition (GO:0035036)	3.58817164
49	synaptic transmission, glutamatergic (GO:0035249)	3.53435749
50	axoneme assembly (GO:0035082)	3.50837276
51	multicellular organismal reproductive process (GO:0048609)	3.47595976
52	nuclear pore organization (GO:0006999)	3.44586229
53	macroautophagy (GO:0016236)	3.42882187
54	innervation (GO:0060384)	3.42316207
55	presynaptic membrane assembly (GO:0097105)	3.41735348
56	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.41719088
57	pore complex assembly (GO:0046931)	3.40007991
58	regulation of cilium movement (GO:0003352)	3.39536585
59	regulation of synaptic vesicle exocytosis (GO:2000300)	3.35619557
60	negative regulation of inclusion body assembly (GO:0090084)	3.33507334
61	RNA destabilization (GO:0050779)	3.33091722
62	alanine transport (GO:0032328)	3.32054327
63	intra-Golgi vesicle-mediated transport (GO:0006891)	3.29774637
64	reproduction (GO:0000003)	3.29005928
65	spermatid nucleus differentiation (GO:0007289)	3.28129224
66	gamma-aminobutyric acid transport (GO:0015812)	3.27107981
67	synaptic vesicle exocytosis (GO:0016079)	3.25986833
68	ventricular system development (GO:0021591)	3.24901435
69	Golgi to endosome transport (GO:0006895)	3.19627334
70	germ cell development (GO:0007281)	3.18956076
71	regulation of meiosis I (GO:0060631)	3.17647427
72	rRNA modification (GO:0000154)	3.15714547
73	auditory behavior (GO:0031223)	3.13207898
74	regulation of synaptic vesicle transport (GO:1902803)	3.10790367
75	opioid receptor signaling pathway (GO:0038003)	3.07775183
76	glutamate secretion (GO:0014047)	3.05532691
77	nucleus organization (GO:0006997)	3.05032144
78	mechanosensory behavior (GO:0007638)	3.04566340
79	positive regulation of neurotransmitter secretion (GO:0001956)	3.01273799
80	presynaptic membrane organization (GO:0097090)	3.01173222
81	binding of sperm to zona pellucida (GO:0007339)	2.98208452
82	retinal rod cell development (GO:0046548)	2.96957016
83	cell-cell recognition (GO:0009988)	2.95728782
84	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.93872225
85	neurotransmitter-gated ion channel clustering (GO:0072578)	2.93285887
86	peptidyl-glutamic acid modification (GO:0018200)	2.91060968
87	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.90888289
88	vesicle transport along microtubule (GO:0047496)	2.89561910
89	response to pheromone (GO:0019236)	2.87580642
90	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.84129689
91	retina layer formation (GO:0010842)	2.80841988
92	chemosensory behavior (GO:0007635)	2.80248210
93	cellular response to pH (GO:0071467)	2.78527710
94	response to auditory stimulus (GO:0010996)	2.77976822
95	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.77243436
96	receptor recycling (GO:0001881)	2.75744501
97	glutamate receptor signaling pathway (GO:0007215)	2.75381580
98	cellular ketone body metabolic process (GO:0046950)	2.74087665
99	positive regulation of neurotransmitter transport (GO:0051590)	2.72320717
100	oogenesis (GO:0048477)	2.71092404

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.11729388
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.69429063
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.00345296
4	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.54183613
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.54139350
6	FUS_26573619_Chip-Seq_HEK293_Human	2.48759048
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.34989876
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.33888886
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19554886
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05562264
11	P300_19829295_ChIP-Seq_ESCs_Human	2.03541346
12	SMAD4_21799915_ChIP-Seq_A2780_Human	2.01592655
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00039911
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.98599885
15	CBP_20019798_ChIP-Seq_JUKART_Human	1.98599885
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.93364291
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.92600846
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.92600846
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.91824988
20	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.90781671
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.89500556
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.84336170
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84182416
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80838640
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.79494689
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78648545
27	STAT3_23295773_ChIP-Seq_U87_Human	1.76822189
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.76458219
29	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.73467851
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.72527602
31	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71166837
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.69577888
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68769871
34	AR_25329375_ChIP-Seq_VCAP_Human	1.65718602
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.61832221
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.58894059
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58542345
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47758953
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47136246
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.46198311
41	TCF4_23295773_ChIP-Seq_U87_Human	1.45903251
42	TBL1_22424771_ChIP-Seq_293T_Human	1.44685078
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43114037
44	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38271859
45	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.37972317
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.37415839
47	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.37153115
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36146058
49	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34735656
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.31986465
51	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.31819461
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30562353
53	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.29973479
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29945382
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28893274
56	NFYB_21822215_ChIP-Seq_K562_Human	1.27496709
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27354304
58	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26176051
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25909830
60	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.24993716
61	TP53_18474530_ChIP-ChIP_U2OS_Human	1.23973159
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.23766823
63	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.23580601
64	PHF8_20622853_ChIP-Seq_HELA_Human	1.23104492
65	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.19685231
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.19298402
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19117499
68	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16908204
69	KDM2B_26808549_Chip-Seq_REH_Human	1.16246658
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15935769
71	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.15547423
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15260064
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15048974
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14962341
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14962341
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.14239089
77	RBPJ_21746931_ChIP-Seq_IB4_Human	1.12672853
78	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.12532498
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12333832
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.12230939
81	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.12096004
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12075214
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11925038
84	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10900975
85	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.09354112
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08904236
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08821636
88	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.08064066
89	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.08006823
90	VDR_22108803_ChIP-Seq_LS180_Human	1.07562391
91	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07542768
92	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.07457670
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06662645
94	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.05378721
95	NFYA_21822215_ChIP-Seq_K562_Human	1.05291600
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.05239683
97	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05237444
98	BCAT_22108803_ChIP-Seq_LS180_Human	1.04703714
99	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04104410
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.02973960

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.11136462
2	MP0004859_abnormal_synaptic_plasticity	3.83842147
3	MP0003878_abnormal_ear_physiology	3.79577635
4	MP0005377_hearing/vestibular/ear_phenot	3.79577635
5	MP0001486_abnormal_startle_reflex	3.20650222
6	MP0003879_abnormal_hair_cell	2.98085530
7	MP0005670_abnormal_white_adipose	2.97268572
8	MP0003136_yellow_coat_color	2.80079323
9	MP0003698_abnormal_male_reproductive	2.68417012
10	MP0004270_analgesia	2.61156605
11	MP0001485_abnormal_pinna_reflex	2.55754648
12	MP0009745_abnormal_behavioral_response	2.48440303
13	MP0009046_muscle_twitch	2.43041578
14	MP0001929_abnormal_gametogenesis	2.42108662
15	MP0001984_abnormal_olfaction	2.18995092
16	MP0003635_abnormal_synaptic_transmissio	2.18030655
17	MP0002064_seizures	2.13167778
18	MP0002572_abnormal_emotion/affect_behav	2.06770303
19	MP0001986_abnormal_taste_sensitivity	1.97633242
20	MP0005310_abnormal_salivary_gland	1.95343740
21	MP0002067_abnormal_sensory_capabilities	1.91099800
22	MP0002272_abnormal_nervous_system	1.90929252
23	MP0001529_abnormal_vocalization	1.83636776
24	MP0002063_abnormal_learning/memory/cond	1.81132992
25	MP0002734_abnormal_mechanical_nocicepti	1.78851708
26	MP0005551_abnormal_eye_electrophysiolog	1.76806881
27	MP0001348_abnormal_lacrimal_gland	1.75952285
28	MP0003880_abnormal_central_pattern	1.73364123
29	MP0005423_abnormal_somatic_nervous	1.73326076
30	MP0004147_increased_porphyrin_level	1.67929768
31	MP0001501_abnormal_sleep_pattern	1.64206266
32	MP0002557_abnormal_social/conspecific_i	1.59929476
33	MP0005253_abnormal_eye_physiology	1.57583208
34	MP0005409_darkened_coat_color	1.56259835
35	MP0001440_abnormal_grooming_behavior	1.56222115
36	MP0002161_abnormal_fertility/fecundity	1.52656236
37	MP0001968_abnormal_touch/_nociception	1.52205143
38	MP0004742_abnormal_vestibular_system	1.51639525
39	MP0003633_abnormal_nervous_system	1.48889313
40	MP0002735_abnormal_chemical_nociception	1.48442172
41	MP0002229_neurodegeneration	1.46893136
42	MP0005248_abnormal_Harderian_gland	1.40692208
43	MP0000955_abnormal_spinal_cord	1.38705710
44	MP0001963_abnormal_hearing_physiology	1.35452023
45	MP0002210_abnormal_sex_determination	1.32792859
46	MP0005647_abnormal_sex_gland	1.31552935
47	MP0010329_abnormal_lipoprotein_level	1.31296090
48	MP0001970_abnormal_pain_threshold	1.29984558
49	MP0008569_lethality_at_weaning	1.29559151
50	MP0001905_abnormal_dopamine_level	1.25955031
51	MP0005379_endocrine/exocrine_gland_phen	1.21488456
52	MP0003631_nervous_system_phenotype	1.18015011
53	MP0002733_abnormal_thermal_nociception	1.17126865
54	MP0000778_abnormal_nervous_system	1.13107859
55	MP0005451_abnormal_body_composition	1.12114985
56	MP0004924_abnormal_behavior	1.11567638
57	MP0005386_behavior/neurological_phenoty	1.11567638
58	MP0008877_abnormal_DNA_methylation	1.10513428
59	MP0003329_amyloid_beta_deposits	1.07318851
60	MP0002882_abnormal_neuron_morphology	1.05339289
61	MP0001145_abnormal_male_reproductive	1.03721388
62	MP0000015_abnormal_ear_pigmentation	1.02059738
63	MP0006276_abnormal_autonomic_nervous	1.00754513
64	MP0000653_abnormal_sex_gland	0.99503291
65	MP0005666_abnormal_adipose_tissue	0.97063744
66	MP0003646_muscle_fatigue	0.96040023
67	MP0003632_abnormal_nervous_system	0.95453657
68	MP0002736_abnormal_nociception_after	0.92363517
69	MP0009115_abnormal_fat_cell	0.91448996
70	MP0000026_abnormal_inner_ear	0.91043324
71	MP0003634_abnormal_glial_cell	0.89765941
72	MP0002066_abnormal_motor_capabilities/c	0.89675052
73	MP0002184_abnormal_innervation	0.87386964
74	MP0005367_renal/urinary_system_phenotyp	0.85641307
75	MP0000516_abnormal_urinary_system	0.85641307
76	MP0005646_abnormal_pituitary_gland	0.85612287
77	MP0003718_maternal_effect	0.84552303
78	MP0000631_abnormal_neuroendocrine_gland	0.83269483
79	MP0002152_abnormal_brain_morphology	0.81076742
80	MP0005645_abnormal_hypothalamus_physiol	0.80950098
81	MP0001188_hyperpigmentation	0.80029917
82	MP0005187_abnormal_penis_morphology	0.77352520
83	MP0000920_abnormal_myelination	0.75170346
84	MP0002876_abnormal_thyroid_physiology	0.74166681
85	MP0001545_abnormal_hematopoietic_system	0.74045013
86	MP0005397_hematopoietic_system_phenotyp	0.74045013
87	MP0004811_abnormal_neuron_physiology	0.73892926
88	MP0008872_abnormal_physiological_respon	0.73524332
89	MP0005391_vision/eye_phenotype	0.73086137
90	MP0006072_abnormal_retinal_apoptosis	0.71066530
91	MP0008995_early_reproductive_senescence	0.70241132
92	MP0003122_maternal_imprinting	0.69895982
93	MP0001919_abnormal_reproductive_system	0.69380374
94	MP0001765_abnormal_ion_homeostasis	0.66974321
95	MP0005636_abnormal_mineral_homeostasis	0.66405103
96	MP0004215_abnormal_myocardial_fiber	0.66314311
97	MP0002822_catalepsy	0.64713648
98	MP0008057_abnormal_DNA_replication	0.64489231
99	MP0002282_abnormal_trachea_morphology	0.64075819
100	MP0003137_abnormal_impulse_conducting	0.62189526

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	8.13078068
2	Tubulointerstitial nephritis (HP:0001970)	5.77557583
3	Focal motor seizures (HP:0011153)	5.46070267
4	Progressive cerebellar ataxia (HP:0002073)	5.16435896
5	Cone-rod dystrophy (HP:0000548)	4.67532568
6	Myokymia (HP:0002411)	4.61922117
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.56571162
8	Absent/shortened dynein arms (HP:0200106)	4.56571162
9	Abnormality of macular pigmentation (HP:0008002)	4.31913928
10	Abnormality of dental color (HP:0011073)	4.05740274
11	Menstrual irregularities (HP:0000858)	4.03096545
12	Hypoalphalipoproteinemia (HP:0003233)	4.00492589
13	Asymmetric septal hypertrophy (HP:0001670)	3.89450082
14	Atonic seizures (HP:0010819)	3.83939801
15	Severe visual impairment (HP:0001141)	3.76645467
16	Amelogenesis imperfecta (HP:0000705)	3.60897853
17	Insulin-resistant diabetes mellitus (HP:0000831)	3.56105092
18	Submucous cleft hard palate (HP:0000176)	3.42684354
19	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.40982039
20	Febrile seizures (HP:0002373)	3.34637431
21	Male infertility (HP:0003251)	3.32651824
22	Focal seizures (HP:0007359)	3.28537176
23	Postural instability (HP:0002172)	3.23208481
24	Epileptic encephalopathy (HP:0200134)	3.02754670
25	Abnormal ciliary motility (HP:0012262)	2.97889112
26	Abnormal respiratory motile cilium physiology (HP:0012261)	2.93562476
27	Truncal obesity (HP:0001956)	2.92162334
28	Renovascular hypertension (HP:0100817)	2.91144082
29	Progressive sensorineural hearing impairment (HP:0000408)	2.86593435
30	Dialeptic seizures (HP:0011146)	2.70742362
31	Resting tremor (HP:0002322)	2.68425145
32	Hyperkalemia (HP:0002153)	2.65855725
33	Bony spicule pigmentary retinopathy (HP:0007737)	2.65352685
34	Nephronophthisis (HP:0000090)	2.65041171
35	Gaze-evoked nystagmus (HP:0000640)	2.63342748
36	Tubulointerstitial abnormality (HP:0001969)	2.60146724
37	Portal hypertension (HP:0001409)	2.57172842
38	Intellectual disability, moderate (HP:0002342)	2.54394499
39	Subcapsular cataract (HP:0000523)	2.53448373
40	Nasal polyposis (HP:0100582)	2.48946395
41	Hypolipoproteinemia (HP:0010981)	2.47756998
42	Abnormal respiratory motile cilium morphology (HP:0005938)	2.46654551
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.46654551
44	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.44142144
45	Attenuation of retinal blood vessels (HP:0007843)	2.34651134
46	Abnormality of the hepatic vasculature (HP:0006707)	2.33409311
47	Absence seizures (HP:0002121)	2.33247078
48	Spontaneous abortion (HP:0005268)	2.32335404
49	Stage 5 chronic kidney disease (HP:0003774)	2.30610476
50	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.30086241
51	Abnormality of the renal medulla (HP:0100957)	2.26967420
52	Infertility (HP:0000789)	2.26649399
53	Hypoplasia of the thymus (HP:0000778)	2.18537598
54	Horizontal nystagmus (HP:0000666)	2.18230285
55	Impaired vibration sensation in the lower limbs (HP:0002166)	2.12099705
56	Action tremor (HP:0002345)	2.08772917
57	Hyperuricemia (HP:0002149)	2.07066739
58	Increased purine levels (HP:0004368)	2.07066739
59	Intestinal atresia (HP:0011100)	2.02637670
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02105134
61	Impulsivity (HP:0100710)	2.01632767
62	Short tibia (HP:0005736)	1.98502404
63	Drooling (HP:0002307)	1.98264141
64	Hypophosphatemic rickets (HP:0004912)	1.98123888
65	Gastrointestinal atresia (HP:0002589)	1.97910200
66	Goiter (HP:0000853)	1.96794917
67	Vacuolated lymphocytes (HP:0001922)	1.96715087
68	Urinary glycosaminoglycan excretion (HP:0003541)	1.94425039
69	Mucopolysacchariduria (HP:0008155)	1.94425039
70	Genetic anticipation (HP:0003743)	1.94049339
71	Hyperventilation (HP:0002883)	1.93254710
72	Rhinitis (HP:0012384)	1.92854089
73	Abnormality of the nasal mucosa (HP:0000433)	1.90291926
74	Hemiparesis (HP:0001269)	1.89847247
75	Neoplasm of the heart (HP:0100544)	1.89432197
76	Esophageal atresia (HP:0002032)	1.86980516
77	Optic nerve hypoplasia (HP:0000609)	1.86914985
78	Growth hormone deficiency (HP:0000824)	1.83789125
79	Papilledema (HP:0001085)	1.79741659
80	Congenital sensorineural hearing impairment (HP:0008527)	1.78341470
81	Excessive salivation (HP:0003781)	1.78297656
82	Fetal akinesia sequence (HP:0001989)	1.76148035
83	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.75165883
84	Abnormality of polysaccharide metabolism (HP:0011012)	1.75165883
85	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.75165883
86	Focal segmental glomerulosclerosis (HP:0000097)	1.75014399
87	Abnormal auditory evoked potentials (HP:0006958)	1.74283643
88	Bradycardia (HP:0001662)	1.73561878
89	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.73232817
90	Dysmetric saccades (HP:0000641)	1.73097536
91	Chronic bronchitis (HP:0004469)	1.72165566
92	Impaired vibratory sensation (HP:0002495)	1.71984880
93	Truncal ataxia (HP:0002078)	1.69984319
94	Insulin resistance (HP:0000855)	1.68831952
95	Abnormality of the astrocytes (HP:0100707)	1.66336323
96	Astrocytoma (HP:0009592)	1.66336323
97	Hypoalbuminemia (HP:0003073)	1.66172626
98	Abnormal albumin level (HP:0012116)	1.66172626
99	Status epilepticus (HP:0002133)	1.66024990
100	Obsessive-compulsive behavior (HP:0000722)	1.65077283

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	6.72721898
2	BRD4	4.47246240
3	PNCK	4.36208037
4	CASK	4.13059561
5	PLK2	3.84154858
6	INSRR	3.57887810
7	CAMK1G	2.48485381
8	FRK	2.36263762
9	NTRK3	2.36219782
10	TYRO3	2.24330377
11	PIK3CG	2.18686222
12	ADRBK2	2.16055178
13	AKT3	2.12491133
14	STK38L	2.08132431
15	MAP4K2	1.89765899
16	STK38	1.79250157
17	NTRK2	1.78640053
18	MARK1	1.64129112
19	TESK1	1.46707560
20	NEK6	1.45254865
21	FGFR2	1.39593023
22	MAPK15	1.35469205
23	PINK1	1.34370195
24	TNIK	1.31863443
25	PRKD3	1.28806378
26	PDK1	1.18187892
27	SIK2	1.13643635
28	SGK2	1.12819039
29	SGK223	1.11089987
30	SGK494	1.11089987
31	PBK	1.05068349
32	MAP3K4	1.04223251
33	PDPK1	0.99470344
34	CDK3	0.96355059
35	CAMK1	0.91509836
36	TIE1	0.91210526
37	CAMK1D	0.85775403
38	BMPR1B	0.81749288
39	LATS2	0.78423755
40	CDK19	0.78318152
41	SGK3	0.77655671
42	CSNK1G2	0.77563729
43	PRKCG	0.77443729
44	CAMKK2	0.75857615
45	OXSR1	0.74686136
46	EPHA4	0.74493809
47	CSNK1G1	0.73935958
48	MAP3K9	0.72862617
49	WNK3	0.72843214
50	STK39	0.72133891
51	SGK1	0.71331260
52	MAP3K2	0.69175448
53	WNK1	0.68221227
54	PTK2B	0.67075746
55	DAPK2	0.66708895
56	MAPK13	0.66222078
57	CAMK2A	0.65069145
58	NTRK1	0.63409227
59	CSNK1G3	0.63196739
60	TAOK1	0.56217146
61	LATS1	0.55915785
62	CDK5	0.54198010
63	CDK8	0.51335763
64	CSNK1A1	0.50411278
65	CSNK1A1L	0.50262926
66	PRKG1	0.49450419
67	KSR2	0.48228770
68	CAMK4	0.47428646
69	EIF2AK3	0.47399301
70	DYRK1B	0.45693063
71	CSNK1D	0.44835845
72	PRKG2	0.39270036
73	BRAF	0.38911828
74	PRKCE	0.37496924
75	STK11	0.36142926
76	ERBB3	0.35142950
77	PRKCZ	0.34421015
78	PRKACB	0.34397500
79	CAMK2B	0.33783416
80	MKNK2	0.32516898
81	ROCK1	0.31115324
82	GSK3B	0.30596731
83	MUSK	0.27905656
84	DYRK1A	0.27288836
85	DYRK3	0.26440885
86	STK3	0.25698554
87	PRKCB	0.25254161
88	YES1	0.25144219
89	MAPK10	0.24393041
90	MAP2K7	0.21825588
91	PDK2	0.21762392
92	CDK1	0.21563768
93	PRKAA2	0.21456021
94	PRKACA	0.21452894
95	PKN1	0.20822961
96	RPS6KA3	0.20375456
97	MAP2K4	0.20232554
98	UHMK1	0.20142799
99	CSNK1E	0.16231121
100	MAPK1	0.16047420

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.25310616
2	Nicotine addiction_Homo sapiens_hsa05033	3.71876337
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.67923373
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.02192082
5	Olfactory transduction_Homo sapiens_hsa04740	2.76042034
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.55870276
7	Taste transduction_Homo sapiens_hsa04742	2.29213820
8	Glutamatergic synapse_Homo sapiens_hsa04724	2.20048464
9	Amphetamine addiction_Homo sapiens_hsa05031	2.11363296
10	Morphine addiction_Homo sapiens_hsa05032	2.06216876
11	GABAergic synapse_Homo sapiens_hsa04727	2.04829775
12	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.03734908
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.01934381
14	Long-term potentiation_Homo sapiens_hsa04720	2.00616552
15	Circadian entrainment_Homo sapiens_hsa04713	1.93191260
16	Cocaine addiction_Homo sapiens_hsa05030	1.71140277
17	Butanoate metabolism_Homo sapiens_hsa00650	1.65446576
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.64280449
19	Insulin secretion_Homo sapiens_hsa04911	1.59426321
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.59140826
21	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.53203131
22	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.45652514
23	Renin secretion_Homo sapiens_hsa04924	1.41298448
24	Serotonergic synapse_Homo sapiens_hsa04726	1.40498198
25	Salivary secretion_Homo sapiens_hsa04970	1.39254901
26	cAMP signaling pathway_Homo sapiens_hsa04024	1.38106430
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.37066370
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28828654
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.25738644
30	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.25430575
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.22468814
32	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.20738430
33	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.18327181
34	Cholinergic synapse_Homo sapiens_hsa04725	1.10474372
35	Phototransduction_Homo sapiens_hsa04744	1.10037443
36	PPAR signaling pathway_Homo sapiens_hsa03320	1.07933611
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.06553752
38	Pancreatic secretion_Homo sapiens_hsa04972	1.04813084
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04305922
40	Type II diabetes mellitus_Homo sapiens_hsa04930	1.03444825
41	Circadian rhythm_Homo sapiens_hsa04710	1.03132397
42	Gastric acid secretion_Homo sapiens_hsa04971	1.02367313
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97292991
44	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.94309820
45	ABC transporters_Homo sapiens_hsa02010	0.94293722
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.93831965
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.93471583
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.93124566
49	Estrogen signaling pathway_Homo sapiens_hsa04915	0.92310491
50	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.90823991
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.85289840
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.82111550
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.81237069
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.79454047
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.77390544
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.76649305
57	Arginine biosynthesis_Homo sapiens_hsa00220	0.75828140
58	Bile secretion_Homo sapiens_hsa04976	0.75377565
59	Long-term depression_Homo sapiens_hsa04730	0.75291064
60	Propanoate metabolism_Homo sapiens_hsa00640	0.74953204
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72685835
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70813556
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.69947726
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.64233559
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.61922403
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.61224621
67	Fatty acid degradation_Homo sapiens_hsa00071	0.57489418
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.56067074
69	Peroxisome_Homo sapiens_hsa04146	0.52403190
70	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51293091
71	RNA transport_Homo sapiens_hsa03013	0.49076888
72	Gap junction_Homo sapiens_hsa04540	0.48854663
73	Oocyte meiosis_Homo sapiens_hsa04114	0.48295186
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.47096027
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46840480
76	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.46053484
77	ErbB signaling pathway_Homo sapiens_hsa04012	0.44697992
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43714214
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43658371
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.43510736
81	mTOR signaling pathway_Homo sapiens_hsa04150	0.41920262
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41580913
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40509438
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40501133
85	Melanogenesis_Homo sapiens_hsa04916	0.40268771
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.39082739
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.38765912
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36969654
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.36714154
90	VEGF signaling pathway_Homo sapiens_hsa04370	0.35479320
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33938552
92	Alcoholism_Homo sapiens_hsa05034	0.33064405
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.31354620
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29624847
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.26038561
96	Glioma_Homo sapiens_hsa05214	0.24967693
97	Tight junction_Homo sapiens_hsa04530	0.23601699
98	Axon guidance_Homo sapiens_hsa04360	0.23273506
99	Mineral absorption_Homo sapiens_hsa04978	0.21683839
100	African trypanosomiasis_Homo sapiens_hsa05143	0.21071308

GXYLT1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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