ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.73606794
2	acrosome reaction (GO:0007340)	7.21308111
3	fusion of sperm to egg plasma membrane (GO:0007342)	7.00113726
4	response to pheromone (GO:0019236)	6.62063195
5	multicellular organism reproduction (GO:0032504)	6.36838205
6	spermatid development (GO:0007286)	5.35596491
7	plasma membrane fusion (GO:0045026)	5.34970881
8	protein polyglutamylation (GO:0018095)	5.30112667
9	cilium or flagellum-dependent cell motility (GO:0001539)	5.23887292
10	establishment of protein localization to Golgi (GO:0072600)	5.01135132
11	regulation of cilium movement (GO:0003352)	4.96312852
12	sperm-egg recognition (GO:0035036)	4.96012847
13	reproduction (GO:0000003)	4.79095632
14	calcium ion-dependent exocytosis (GO:0017156)	4.55078012
15	protein targeting to Golgi (GO:0000042)	4.48105414
16	single fertilization (GO:0007338)	4.30659612
17	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.29588413
18	motile cilium assembly (GO:0044458)	4.29391563
19	binding of sperm to zona pellucida (GO:0007339)	4.26082718
20	sperm capacitation (GO:0048240)	4.22324697
21	cell-cell recognition (GO:0009988)	4.17971657
22	axonemal dynein complex assembly (GO:0070286)	4.16705480
23	epithelial cilium movement (GO:0003351)	4.15769812
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.07430933
25	cellular ketone body metabolic process (GO:0046950)	4.05370569
26	phosphatidylethanolamine metabolic process (GO:0046337)	4.04568593
27	microtubule severing (GO:0051013)	4.04450284
28	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.90591050
29	male meiosis (GO:0007140)	3.89900205
30	indole-containing compound catabolic process (GO:0042436)	3.89861409
31	indolalkylamine catabolic process (GO:0046218)	3.89861409
32	tryptophan catabolic process (GO:0006569)	3.89861409
33	spermatogenesis (GO:0007283)	3.87653335
34	cilium movement (GO:0003341)	3.87329757
35	microtubule polymerization or depolymerization (GO:0031109)	3.86953654
36	male gamete generation (GO:0048232)	3.86452294
37	fertilization (GO:0009566)	3.61473170
38	gamete generation (GO:0007276)	3.60218568
39	centriole replication (GO:0007099)	3.57407888
40	microtubule depolymerization (GO:0007019)	3.53438818
41	ketone body metabolic process (GO:1902224)	3.51074013
42	single strand break repair (GO:0000012)	3.44862702
43	negative regulation of inclusion body assembly (GO:0090084)	3.42435965
44	axoneme assembly (GO:0035082)	3.42053316
45	organic cation transport (GO:0015695)	3.39719841
46	photoreceptor cell maintenance (GO:0045494)	3.38181291
47	synapsis (GO:0007129)	3.36126793
48	germ cell development (GO:0007281)	3.33915272
49	membrane depolarization during action potential (GO:0086010)	3.29776256
50	detection of light stimulus involved in visual perception (GO:0050908)	3.23228719
51	detection of light stimulus involved in sensory perception (GO:0050962)	3.23228719
52	coenzyme catabolic process (GO:0009109)	3.19325482
53	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.15395708
54	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.08982162
55	centriole assembly (GO:0098534)	3.05025358
56	regulation of Rab GTPase activity (GO:0032313)	3.04645003
57	positive regulation of Rab GTPase activity (GO:0032851)	3.04645003
58	ventricular system development (GO:0021591)	3.03687256
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03580641
60	glomerular visceral epithelial cell development (GO:0072015)	3.02996961
61	protein localization to Golgi apparatus (GO:0034067)	3.02608139
62	regulation of microtubule-based movement (GO:0060632)	3.00138368
63	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.98968528
64	one-carbon compound transport (GO:0019755)	2.98467361
65	indolalkylamine metabolic process (GO:0006586)	2.97864266
66	gamma-aminobutyric acid transport (GO:0015812)	2.96953541
67	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.95530453
68	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.93307903
69	cell wall macromolecule metabolic process (GO:0044036)	2.92698467
70	oogenesis (GO:0048477)	2.92515232
71	relaxation of smooth muscle (GO:0044557)	2.85410468
72	tryptophan metabolic process (GO:0006568)	2.84435116
73	seminiferous tubule development (GO:0072520)	2.84281764
74	multicellular organismal reproductive process (GO:0048609)	2.83542654
75	retinal cone cell development (GO:0046549)	2.83020805
76	cilium assembly (GO:0042384)	2.80934719
77	cilium organization (GO:0044782)	2.79636920
78	DNA packaging (GO:0006323)	2.79567699
79	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.79504151
80	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.75005100
81	methionine biosynthetic process (GO:0009086)	2.74357987
82	rRNA methylation (GO:0031167)	2.74253525
83	glomerular epithelial cell development (GO:0072310)	2.72386017
84	cell wall macromolecule catabolic process (GO:0016998)	2.71899740
85	regulation of acrosome reaction (GO:0060046)	2.67292798
86	long term synaptic depression (GO:0060292)	2.67077863
87	multicellular organismal movement (GO:0050879)	2.66780439
88	musculoskeletal movement (GO:0050881)	2.66780439
89	polyamine biosynthetic process (GO:0006596)	2.66248788
90	brain morphogenesis (GO:0048854)	2.63482154
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63206946
92	regulation of sarcomere organization (GO:0060297)	2.62710565
93	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.61367753
94	chromosome condensation (GO:0030261)	2.59763770
95	indole-containing compound metabolic process (GO:0042430)	2.57676222
96	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.56719920
97	presynaptic membrane assembly (GO:0097105)	2.56365619
98	primary amino compound metabolic process (GO:1901160)	2.54680166
99	regulation of gene silencing by RNA (GO:0060966)	2.54256847
100	regulation of gene silencing by miRNA (GO:0060964)	2.54256847

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.45484215
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.62396460
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.14849762
4	VDR_22108803_ChIP-Seq_LS180_Human	2.80644558
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.77161737
6	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.58545908
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.50852223
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46544479
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40471780
10	FUS_26573619_Chip-Seq_HEK293_Human	2.14531012
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.14419615
12	P300_19829295_ChIP-Seq_ESCs_Human	2.11206831
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09382094
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.08965843
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04790177
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02999861
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.98022990
18	SMAD4_21799915_ChIP-Seq_A2780_Human	1.97342653
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.95349124
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.95349124
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.94974573
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90372381
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.90372381
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.87769984
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.86190410
26	STAT3_23295773_ChIP-Seq_U87_Human	1.85706588
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79648587
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.71811206
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.69827881
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68801721
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.65463858
32	AR_25329375_ChIP-Seq_VCAP_Human	1.65143726
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.53124582
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.53124582
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.52241290
36	TCF4_23295773_ChIP-Seq_U87_Human	1.52109907
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50666213
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.48424593
39	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48290580
40	DROSHA_22980978_ChIP-Seq_HELA_Human	1.43983183
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.43448255
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.42287110
43	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.41509107
44	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.38880259
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35550660
46	TBL1_22424771_ChIP-Seq_293T_Human	1.35369570
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.33897557
48	AHR_22903824_ChIP-Seq_MCF-7_Human	1.31537971
49	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25411516
50	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.25024944
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24630372
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24439805
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23856816
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.22801152
55	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21454264
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21305836
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21097885
58	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21081871
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19607763
60	NFYB_21822215_ChIP-Seq_K562_Human	1.19564456
61	EWS_26573619_Chip-Seq_HEK293_Human	1.18255788
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.16590545
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16076423
64	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.15647490
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.15114472
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.14688607
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14065480
68	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.13988581
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13090807
70	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.13025674
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12882713
72	PHF8_20622853_ChIP-Seq_HELA_Human	1.12011277
73	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.10742966
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10533822
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10479507
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.09534294
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09201826
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08137198
79	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07122866
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07018230
81	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06571288
82	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.06542188
83	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05357398
84	NFYA_21822215_ChIP-Seq_K562_Human	1.04598536
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.04507111
86	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03853072
87	CJUN_26792858_Chip-Seq_BT549_Human	1.03420971
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03308197
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03061894
90	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.03034850
91	RXR_22108803_ChIP-Seq_LS180_Human	1.02905901
92	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.02596590
93	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.02509305
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02142699
95	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.01497527
96	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.00037611
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99312463
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98516090
99	KDM2B_26808549_Chip-Seq_REH_Human	0.98225710
100	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98182746

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.58696884
2	MP0003136_yellow_coat_color	4.23151189
3	MP0005377_hearing/vestibular/ear_phenot	3.14037332
4	MP0003878_abnormal_ear_physiology	3.14037332
5	MP0005670_abnormal_white_adipose	3.10871182
6	MP0003698_abnormal_male_reproductive	2.80608370
7	MP0005551_abnormal_eye_electrophysiolog	2.65504250
8	MP0001984_abnormal_olfaction	2.64560406
9	MP0001929_abnormal_gametogenesis	2.47109985
10	MP0003646_muscle_fatigue	2.43619680
11	MP0006072_abnormal_retinal_apoptosis	2.39462704
12	MP0003879_abnormal_hair_cell	2.36916952
13	MP0001486_abnormal_startle_reflex	2.36223562
14	MP0005253_abnormal_eye_physiology	2.31202355
15	MP0001968_abnormal_touch/_nociception	2.28115985
16	MP0001485_abnormal_pinna_reflex	2.26453067
17	MP0009046_muscle_twitch	2.22163110
18	MP0002736_abnormal_nociception_after	2.07084525
19	MP0003195_calcinosis	2.06542786
20	MP0001501_abnormal_sleep_pattern	1.85840893
21	MP0004859_abnormal_synaptic_plasticity	1.85659723
22	MP0009745_abnormal_behavioral_response	1.77968970
23	MP0005647_abnormal_sex_gland	1.68020818
24	MP0005085_abnormal_gallbladder_physiolo	1.65052133
25	MP0002272_abnormal_nervous_system	1.62951378
26	MP0002876_abnormal_thyroid_physiology	1.62166443
27	MP0010329_abnormal_lipoprotein_level	1.59047114
28	MP0002572_abnormal_emotion/affect_behav	1.58584600
29	MP0003880_abnormal_central_pattern	1.46588391
30	MP0003718_maternal_effect	1.46181509
31	MP0000569_abnormal_digit_pigmentation	1.44214088
32	MP0003635_abnormal_synaptic_transmissio	1.43542257
33	MP0002064_seizures	1.43002758
34	MP0001986_abnormal_taste_sensitivity	1.42610021
35	MP0003011_delayed_dark_adaptation	1.41830237
36	MP0002067_abnormal_sensory_capabilities	1.41359920
37	MP0004742_abnormal_vestibular_system	1.40379735
38	MP0002210_abnormal_sex_determination	1.38926565
39	MP0002161_abnormal_fertility/fecundity	1.38240834
40	MP0005423_abnormal_somatic_nervous	1.37823505
41	MP0005365_abnormal_bile_salt	1.36074217
42	MP0004215_abnormal_myocardial_fiber	1.34726540
43	MP0001970_abnormal_pain_threshold	1.29104205
44	MP0001963_abnormal_hearing_physiology	1.27716499
45	MP0008004_abnormal_stomach_pH	1.26797012
46	MP0002734_abnormal_mechanical_nocicepti	1.26645285
47	MP0002138_abnormal_hepatobiliary_system	1.25358116
48	MP0002229_neurodegeneration	1.24228562
49	MP0004043_abnormal_pH_regulation	1.24026997
50	MP0005646_abnormal_pituitary_gland	1.22788189
51	MP0002733_abnormal_thermal_nociception	1.20272505
52	MP0000538_abnormal_urinary_bladder	1.18454233
53	MP0001145_abnormal_male_reproductive	1.15380940
54	MP0002139_abnormal_hepatobiliary_system	1.15306442
55	MP0000653_abnormal_sex_gland	1.11993971
56	MP0004270_analgesia	1.11422969
57	MP0006276_abnormal_autonomic_nervous	1.10779824
58	MP0004036_abnormal_muscle_relaxation	1.09476734
59	MP0004084_abnormal_cardiac_muscle	1.07995610
60	MP0002557_abnormal_social/conspecific_i	1.06482018
61	MP0005187_abnormal_penis_morphology	1.03140398
62	MP0001905_abnormal_dopamine_level	1.03122604
63	MP0000230_abnormal_systemic_arterial	1.03056583
64	MP0002735_abnormal_chemical_nociception	1.00860881
65	MP0008872_abnormal_physiological_respon	1.00765208
66	MP0002160_abnormal_reproductive_system	0.99509932
67	MP0002063_abnormal_learning/memory/cond	0.98997862
68	MP0005391_vision/eye_phenotype	0.98925965
69	MP0003633_abnormal_nervous_system	0.98120373
70	MP0004484_altered_response_of	0.96077528
71	MP0005379_endocrine/exocrine_gland_phen	0.96013560
72	MP0000427_abnormal_hair_cycle	0.94508019
73	MP0008775_abnormal_heart_ventricle	0.93032981
74	MP0005332_abnormal_amino_acid	0.92400944
75	MP0005367_renal/urinary_system_phenotyp	0.88480616
76	MP0000516_abnormal_urinary_system	0.88480616
77	MP0000026_abnormal_inner_ear	0.85150563
78	MP0001529_abnormal_vocalization	0.82828270
79	MP0005360_urolithiasis	0.81763224
80	MP0008995_early_reproductive_senescence	0.81451057
81	MP0001666_abnormal_nutrient_absorption	0.81149205
82	MP0003631_nervous_system_phenotype	0.80904253
83	MP0001764_abnormal_homeostasis	0.80692321
84	MP0005310_abnormal_salivary_gland	0.78659752
85	MP0004085_abnormal_heartbeat	0.78225731
86	MP0005248_abnormal_Harderian_gland	0.77948594
87	MP0008875_abnormal_xenobiotic_pharmacok	0.77897014
88	MP0010386_abnormal_urinary_bladder	0.76562650
89	MP0001756_abnormal_urination	0.76144063
90	MP0001765_abnormal_ion_homeostasis	0.75445466
91	MP0002132_abnormal_respiratory_system	0.74787488
92	MP0001664_abnormal_digestion	0.74167271
93	MP0005195_abnormal_posterior_eye	0.72260750
94	MP0002090_abnormal_vision	0.72129508
95	MP0004147_increased_porphyrin_level	0.68175510
96	MP0005386_behavior/neurological_phenoty	0.67037649
97	MP0004924_abnormal_behavior	0.67037649
98	MP0000631_abnormal_neuroendocrine_gland	0.67035320
99	MP0005266_abnormal_metabolism	0.66161026
100	MP0003632_abnormal_nervous_system	0.65284206

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	5.72577653
2	Severe visual impairment (HP:0001141)	4.58165095
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.37775068
4	Absent/shortened dynein arms (HP:0200106)	4.37775068
5	Congenital stationary night blindness (HP:0007642)	4.29733473
6	Attenuation of retinal blood vessels (HP:0007843)	4.21370320
7	Bony spicule pigmentary retinopathy (HP:0007737)	4.20272757
8	Progressive cerebellar ataxia (HP:0002073)	4.08699779
9	Abnormal ciliary motility (HP:0012262)	4.06380691
10	Tubulointerstitial nephritis (HP:0001970)	4.01927149
11	Abnormality of macular pigmentation (HP:0008002)	3.83861404
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.59958409
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.51717340
14	Protruding tongue (HP:0010808)	3.48591115
15	Congenital sensorineural hearing impairment (HP:0008527)	3.42336129
16	Pancreatic cysts (HP:0001737)	3.30810217
17	True hermaphroditism (HP:0010459)	3.22789253
18	Postural instability (HP:0002172)	3.00627095
19	Abnormal respiratory motile cilium morphology (HP:0005938)	2.89980103
20	Abnormal respiratory epithelium morphology (HP:0012253)	2.89980103
21	Gaze-evoked nystagmus (HP:0000640)	2.84397109
22	Pancreatic fibrosis (HP:0100732)	2.80357222
23	Nephronophthisis (HP:0000090)	2.73145315
24	Atonic seizures (HP:0010819)	2.69933267
25	Cone-rod dystrophy (HP:0000548)	2.63128588
26	Abnormality of dental color (HP:0011073)	2.62972796
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.58301269
28	Medial flaring of the eyebrow (HP:0010747)	2.56384620
29	Resting tremor (HP:0002322)	2.55113906
30	Bile duct proliferation (HP:0001408)	2.50008671
31	Abnormal biliary tract physiology (HP:0012439)	2.50008671
32	Azoospermia (HP:0000027)	2.48682174
33	Poor coordination (HP:0002370)	2.45100107
34	Absent speech (HP:0001344)	2.44925793
35	Optic nerve hypoplasia (HP:0000609)	2.43772923
36	Infertility (HP:0000789)	2.43658758
37	Gonadal dysgenesis (HP:0000133)	2.41681428
38	Hyperglycinemia (HP:0002154)	2.40912226
39	Abolished electroretinogram (ERG) (HP:0000550)	2.40631695
40	Abnormality of the renal medulla (HP:0100957)	2.39700437
41	Abnormality of vitamin B metabolism (HP:0004340)	2.39201378
42	Cerebellar dysplasia (HP:0007033)	2.39004659
43	Male infertility (HP:0003251)	2.36432687
44	Male pseudohermaphroditism (HP:0000037)	2.33104114
45	Sex reversal (HP:0012245)	2.31625674
46	Abnormal sex determination (HP:0012244)	2.31625674
47	Clumsiness (HP:0002312)	2.31221454
48	Abnormal spermatogenesis (HP:0008669)	2.29845597
49	Supernumerary spleens (HP:0009799)	2.25470828
50	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.25353133
51	Congenital primary aphakia (HP:0007707)	2.24686819
52	Focal motor seizures (HP:0011153)	2.24649849
53	Gait imbalance (HP:0002141)	2.24329032
54	Febrile seizures (HP:0002373)	2.24083020
55	Asymmetric septal hypertrophy (HP:0001670)	2.23221524
56	Cystic liver disease (HP:0006706)	2.23132123
57	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19633814
58	Inability to walk (HP:0002540)	2.18249628
59	Decreased central vision (HP:0007663)	2.16757345
60	Impulsivity (HP:0100710)	2.15758167
61	Amelogenesis imperfecta (HP:0000705)	2.12382610
62	Hypoplasia of the fovea (HP:0007750)	2.12225422
63	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.12225422
64	Rhinitis (HP:0012384)	2.12174081
65	Type II lissencephaly (HP:0007260)	2.11916112
66	Chronic sinusitis (HP:0011109)	2.11645106
67	Horizontal nystagmus (HP:0000666)	2.10909115
68	Sensory axonal neuropathy (HP:0003390)	2.10618143
69	Hyperkalemia (HP:0002153)	2.10452764
70	Abnormal drinking behavior (HP:0030082)	2.09977364
71	Polydipsia (HP:0001959)	2.09977364
72	Congenital hepatic fibrosis (HP:0002612)	2.09124620
73	Portal hypertension (HP:0001409)	2.07012203
74	Abnormality of midbrain morphology (HP:0002418)	2.05144803
75	Molar tooth sign on MRI (HP:0002419)	2.05144803
76	Hemiparesis (HP:0001269)	2.02205631
77	Hyperventilation (HP:0002883)	1.99172607
78	Occipital encephalocele (HP:0002085)	1.97940624
79	Tubulointerstitial abnormality (HP:0001969)	1.97907165
80	Abnormality of the renal cortex (HP:0011035)	1.97216782
81	Genital tract atresia (HP:0001827)	1.95125555
82	Central scotoma (HP:0000603)	1.93454205
83	Abnormality of the hepatic vasculature (HP:0006707)	1.90782806
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90106250
85	Proximal tubulopathy (HP:0000114)	1.90103220
86	Genetic anticipation (HP:0003743)	1.89392650
87	Vaginal atresia (HP:0000148)	1.87495318
88	Focal seizures (HP:0007359)	1.87494136
89	Hypoplasia of the thymus (HP:0000778)	1.87023214
90	Retinal atrophy (HP:0001105)	1.83559924
91	Polyuria (HP:0000103)	1.83477900
92	Abnormality of the fovea (HP:0000493)	1.81859605
93	Abnormal urine output (HP:0012590)	1.81693821
94	Abnormality of vitamin metabolism (HP:0100508)	1.81597109
95	Nephrogenic diabetes insipidus (HP:0009806)	1.81258242
96	Scotoma (HP:0000575)	1.80957373
97	Large for gestational age (HP:0001520)	1.80587150
98	Facial shape deformation (HP:0011334)	1.77599606
99	Potter facies (HP:0002009)	1.77599606
100	Abnormality of binocular vision (HP:0011514)	1.76802174

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.62979512
2	TESK2	5.06750208
3	PINK1	3.94410368
4	MAP4K2	3.91384598
5	PLK4	3.91075404
6	CASK	3.90744338
7	GRK1	3.11878144
8	INSRR	2.84958054
9	ZAK	2.45910864
10	STK38L	2.25655996
11	EIF2AK3	2.10166557
12	PLK2	2.03491611
13	PIK3CG	1.94823866
14	PNCK	1.88954603
15	STK38	1.68366254
16	ACVR1B	1.59753019
17	PRKD3	1.51892783
18	MARK3	1.49477504
19	WNK3	1.44523239
20	MAPK15	1.32353256
21	FGFR2	1.31464635
22	CAMK1G	1.22459841
23	OXSR1	1.12936547
24	STK39	1.00262591
25	AKT3	0.99888791
26	LATS2	0.99143555
27	NTRK3	0.98038970
28	CCNB1	0.96552116
29	BMPR1B	0.92079915
30	WNK4	0.89495471
31	BRD4	0.86696815
32	PDK1	0.79255743
33	SGK494	0.76688280
34	SGK223	0.76688280
35	PTK2B	0.75898428
36	TIE1	0.74889969
37	LATS1	0.74721863
38	NTRK2	0.73640724
39	MAP3K13	0.72226608
40	ADRBK2	0.70590243
41	MAP2K7	0.70269506
42	PDPK1	0.68872530
43	TLK1	0.68304256
44	MAP3K4	0.68117762
45	MAPKAPK3	0.67684157
46	PRKCG	0.67335927
47	MAP3K9	0.65551209
48	RPS6KA5	0.62808405
49	SGK2	0.62289328
50	MYLK	0.61624440
51	STK3	0.59289603
52	EPHA4	0.58580514
53	CAMK1	0.57823301
54	NEK6	0.56623389
55	PRKCE	0.54843980
56	DDR2	0.53124052
57	CSNK1G2	0.52169123
58	SIK2	0.51404804
59	TRPM7	0.49897053
60	MAPK13	0.49729407
61	ROCK1	0.49616298
62	PRKAA2	0.48618426
63	CDK19	0.45545204
64	MKNK2	0.44972202
65	CAMK2A	0.44880652
66	TNK2	0.44626727
67	TNIK	0.44252644
68	MARK1	0.43977467
69	PRKCQ	0.43880678
70	DYRK3	0.43222498
71	OBSCN	0.43152054
72	PRKG1	0.42607894
73	TAOK1	0.42496114
74	CSNK1G3	0.42347002
75	WNK1	0.41402057
76	CSNK1G1	0.40336389
77	PRKACB	0.37733910
78	CAMK1D	0.37329529
79	CAMK2B	0.36541078
80	SGK1	0.36186881
81	TYRO3	0.34496677
82	CSNK1A1L	0.32328238
83	PKN1	0.31213330
84	GRK7	0.30733221
85	ADRBK1	0.30296545
86	PRKG2	0.29622557
87	PRKACA	0.29378989
88	PRKCB	0.29237520
89	PRKAA1	0.29048836
90	CSNK1A1	0.28573691
91	CDK5	0.27139369
92	MAPK11	0.25151093
93	MKNK1	0.24013529
94	NEK2	0.23501432
95	CDK3	0.23272741
96	PRKCZ	0.22903753
97	PHKG1	0.22877859
98	PHKG2	0.22877859
99	CSNK1D	0.22832809
100	MAPK10	0.21089347

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.36229838
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.22340863
3	Butanoate metabolism_Homo sapiens_hsa00650	3.00859686
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.83618950
5	Olfactory transduction_Homo sapiens_hsa04740	2.64391129
6	Phototransduction_Homo sapiens_hsa04744	2.56797004
7	Nicotine addiction_Homo sapiens_hsa05033	2.47316466
8	Propanoate metabolism_Homo sapiens_hsa00640	2.12981582
9	Taste transduction_Homo sapiens_hsa04742	2.11666549
10	Tryptophan metabolism_Homo sapiens_hsa00380	1.96678414
11	ABC transporters_Homo sapiens_hsa02010	1.84429703
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.72844396
13	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69215101
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68613759
15	Salivary secretion_Homo sapiens_hsa04970	1.67854773
16	Caffeine metabolism_Homo sapiens_hsa00232	1.65475062
17	Circadian entrainment_Homo sapiens_hsa04713	1.60353149
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.56440136
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.50959823
20	PPAR signaling pathway_Homo sapiens_hsa03320	1.50712236
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.50456243
22	Retinol metabolism_Homo sapiens_hsa00830	1.50419982
23	Fatty acid degradation_Homo sapiens_hsa00071	1.48780365
24	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.48324009
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.48074698
26	Morphine addiction_Homo sapiens_hsa05032	1.42204710
27	GABAergic synapse_Homo sapiens_hsa04727	1.38514274
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38089598
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.34928471
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34022531
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.32432055
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32307660
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.27288357
34	Bile secretion_Homo sapiens_hsa04976	1.25185687
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23145828
36	Calcium signaling pathway_Homo sapiens_hsa04020	1.19666521
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.16725868
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.13428381
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.13337397
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.11659817
41	Gastric acid secretion_Homo sapiens_hsa04971	1.10236964
42	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.09541813
43	Amphetamine addiction_Homo sapiens_hsa05031	1.07426137
44	Renin secretion_Homo sapiens_hsa04924	1.05087603
45	Insulin secretion_Homo sapiens_hsa04911	1.05053260
46	Glycerolipid metabolism_Homo sapiens_hsa00561	1.04721080
47	Histidine metabolism_Homo sapiens_hsa00340	1.02644772
48	Gap junction_Homo sapiens_hsa04540	1.02370234
49	Serotonergic synapse_Homo sapiens_hsa04726	1.02067808
50	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00731039
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.98451166
52	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93214221
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.90358914
54	One carbon pool by folate_Homo sapiens_hsa00670	0.90137469
55	Arginine biosynthesis_Homo sapiens_hsa00220	0.86711290
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84155508
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.80483697
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.79642188
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77938549
60	Circadian rhythm_Homo sapiens_hsa04710	0.76405005
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.75722125
62	Peroxisome_Homo sapiens_hsa04146	0.75277444
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74277752
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70253887
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69997885
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68486312
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.67690659
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67259863
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.66660878
70	Pancreatic secretion_Homo sapiens_hsa04972	0.66652852
71	Cocaine addiction_Homo sapiens_hsa05030	0.65949128
72	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.65779104
73	Mineral absorption_Homo sapiens_hsa04978	0.63237053
74	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.62886941
75	Lysine degradation_Homo sapiens_hsa00310	0.60581543
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58518462
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56875299
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.56442826
79	Pyruvate metabolism_Homo sapiens_hsa00620	0.56179927
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.54022269
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52717660
82	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51743330
83	Long-term potentiation_Homo sapiens_hsa04720	0.49902592
84	Alcoholism_Homo sapiens_hsa05034	0.49714675
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.48166224
86	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47144696
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46662718
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45902692
89	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.45475794
90	Cholinergic synapse_Homo sapiens_hsa04725	0.45328400
91	Type II diabetes mellitus_Homo sapiens_hsa04930	0.44391772
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.42982543
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.42806507
94	Long-term depression_Homo sapiens_hsa04730	0.42619857
95	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.41364783
96	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40934925
97	Fatty acid elongation_Homo sapiens_hsa00062	0.38589505
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38489788
99	Metabolic pathways_Homo sapiens_hsa01100	0.34293435
100	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33490799

GXYLT1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »