ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell morphogenesis involved in neuron differentiation (GO:0048667)	9.43864067
2	post-embryonic morphogenesis (GO:0009886)	6.53656691
3	intestinal cholesterol absorption (GO:0030299)	5.44967779
4	long term synaptic depression (GO:0060292)	5.11593376
5	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.75639725
6	very-low-density lipoprotein particle assembly (GO:0034379)	4.72458230
7	oogenesis (GO:0048477)	4.70082232
8	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.55617847
9	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.51704388
10	synapsis (GO:0007129)	4.41472714
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.37820038
12	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.36469697
13	cell wall macromolecule catabolic process (GO:0016998)	4.31686525
14	short-chain fatty acid metabolic process (GO:0046459)	4.24595981
15	negative regulation of gene silencing (GO:0060969)	4.22566243
16	nephron tubule formation (GO:0072079)	4.16427403
17	mitochondrial DNA replication (GO:0006264)	4.15639918
18	rhodopsin mediated signaling pathway (GO:0016056)	4.10057928
19	intraciliary transport (GO:0042073)	4.00963685
20	nephron tubule morphogenesis (GO:0072078)	3.99927409
21	nephron epithelium morphogenesis (GO:0072088)	3.99927409
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.90338361
23	regulation of gene silencing by RNA (GO:0060966)	3.86282149
24	regulation of posttranscriptional gene silencing (GO:0060147)	3.86282149
25	regulation of gene silencing by miRNA (GO:0060964)	3.86282149
26	mitotic G2 DNA damage checkpoint (GO:0007095)	3.82800579
27	mitochondrial genome maintenance (GO:0000002)	3.82404276
28	somite development (GO:0061053)	3.72393024
29	multicellular organism reproduction (GO:0032504)	3.72195425
30	antigen processing and presentation of endogenous antigen (GO:0019883)	3.69738964
31	cell wall macromolecule metabolic process (GO:0044036)	3.65308467
32	collecting duct development (GO:0072044)	3.63671865
33	negative regulation of cAMP-mediated signaling (GO:0043951)	3.52050731
34	immunoglobulin mediated immune response (GO:0016064)	3.45700162
35	renal tubule morphogenesis (GO:0061333)	3.44739007
36	behavioral response to nicotine (GO:0035095)	3.40828811
37	folic acid metabolic process (GO:0046655)	3.36430269
38	one-carbon compound transport (GO:0019755)	3.29669473
39	indole-containing compound catabolic process (GO:0042436)	3.28208724
40	indolalkylamine catabolic process (GO:0046218)	3.28208724
41	tryptophan catabolic process (GO:0006569)	3.28208724
42	mechanosensory behavior (GO:0007638)	3.27539724
43	histone H3-K9 modification (GO:0061647)	3.25022851
44	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	3.18737736
45	S-adenosylmethionine metabolic process (GO:0046500)	3.17235117
46	negative regulation of activin receptor signaling pathway (GO:0032926)	3.15987809
47	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.15601744
48	DNA damage response, detection of DNA damage (GO:0042769)	3.14673098
49	mRNA cleavage (GO:0006379)	3.13494792
50	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	3.13051856
51	positive regulation of CREB transcription factor activity (GO:0032793)	3.11301510
52	cholesterol efflux (GO:0033344)	3.09344919
53	negative regulation of astrocyte differentiation (GO:0048712)	3.09193659
54	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.09110221
55	histone H3-K9 methylation (GO:0051567)	3.08016637
56	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	3.06420182
57	ether lipid metabolic process (GO:0046485)	3.06271897
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.05347250
59	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.99775820
60	regulation of glutamate receptor signaling pathway (GO:1900449)	2.99281829
61	folic acid-containing compound biosynthetic process (GO:0009396)	2.97573175
62	platelet dense granule organization (GO:0060155)	2.95181506
63	kidney morphogenesis (GO:0060993)	2.93478629
64	histone H2A acetylation (GO:0043968)	2.92191377
65	negative regulation of mast cell activation (GO:0033004)	2.92138615
66	cornea development in camera-type eye (GO:0061303)	2.88128849
67	axon ensheathment in central nervous system (GO:0032291)	2.88124854
68	central nervous system myelination (GO:0022010)	2.88124854
69	metallo-sulfur cluster assembly (GO:0031163)	2.84496888
70	iron-sulfur cluster assembly (GO:0016226)	2.84496888
71	regulation of collateral sprouting (GO:0048670)	2.83905225
72	positive thymic T cell selection (GO:0045059)	2.81478432
73	estrogen biosynthetic process (GO:0006703)	2.77429494
74	peroxisome organization (GO:0007031)	2.74350230
75	peptidyl-lysine dimethylation (GO:0018027)	2.74067274
76	vitamin biosynthetic process (GO:0009110)	2.72387916
77	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.72252122
78	cellular response to electrical stimulus (GO:0071257)	2.71728086
79	female gamete generation (GO:0007292)	2.70303310
80	positive regulation of potassium ion transport (GO:0043268)	2.69554637
81	regulation of skeletal muscle cell differentiation (GO:2001014)	2.69074218
82	energy homeostasis (GO:0097009)	2.68418616
83	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.67961508
84	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.64593789
85	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	2.63820548
86	negative regulation of lipid catabolic process (GO:0050995)	2.62599891
87	auditory behavior (GO:0031223)	2.61329651
88	phosphorelay signal transduction system (GO:0000160)	2.60221610
89	C4-dicarboxylate transport (GO:0015740)	2.60194859
90	male meiosis I (GO:0007141)	2.59909271
91	imidazole-containing compound metabolic process (GO:0052803)	2.59290609
92	peristalsis (GO:0030432)	2.58603446
93	L-methionine salvage (GO:0071267)	2.58019665
94	L-methionine biosynthetic process (GO:0071265)	2.58019665
95	amino acid salvage (GO:0043102)	2.58019665
96	mitotic G2/M transition checkpoint (GO:0044818)	2.56273844
97	ethanol oxidation (GO:0006069)	2.55233079
98	B cell mediated immunity (GO:0019724)	2.55224489
99	regulation of meiosis I (GO:0060631)	2.54665068
100	response to pheromone (GO:0019236)	11.2979057

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.18931918
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.58776558
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.31873765
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.10996861
5	VDR_22108803_ChIP-Seq_LS180_Human	2.78194796
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.53226760
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.45117998
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.43351082
9	EWS_26573619_Chip-Seq_HEK293_Human	2.40566154
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29478239
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15425063
12	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.13529656
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12671641
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05509324
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.94097673
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92589874
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.79950277
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78429404
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.74404027
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.73820622
21	P300_19829295_ChIP-Seq_ESCs_Human	1.73269038
22	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.69615195
23	AR_25329375_ChIP-Seq_VCAP_Human	1.68144192
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.65209188
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63346790
26	NANOG_19829295_ChIP-Seq_ESCs_Human	1.59015379
27	SOX2_19829295_ChIP-Seq_ESCs_Human	1.59015379
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58601719
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58052457
30	RUNX2_22187159_ChIP-Seq_PCA_Human	1.53960834
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52477438
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48882961
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.42538436
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40140179
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39898711
36	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39593123
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.38580586
38	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.36130385
39	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34325624
40	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.33528025
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33268016
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32518051
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32444682
44	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30909832
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30253713
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30179156
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.29624896
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29624896
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29604227
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29321906
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27566593
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26730203
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26308316
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26243441
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25816450
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24321353
57	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.23840532
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23780372
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.23693510
60	TCF4_23295773_ChIP-Seq_U87_Human	1.22744981
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22559917
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21981903
63	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.21521933
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21337397
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21337397
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20852087
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.19911845
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17562854
69	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15757046
70	STAT3_23295773_ChIP-Seq_U87_Human	1.15279970
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14873744
72	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14859581
73	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.14454068
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.12985218
75	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.12341165
76	GBX2_23144817_ChIP-Seq_PC3_Human	1.07080469
77	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06315791
78	JUN_21703547_ChIP-Seq_K562_Human	1.05399936
79	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05258351
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.04267936
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02923692
82	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01600684
83	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.00761556
84	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98350125
85	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.98307260
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97965999
87	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97604572
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97352514
89	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.97299396
90	RXR_22108803_ChIP-Seq_LS180_Human	0.96098730
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95148435
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.94739673
93	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.93102967
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.93067303
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92965325
96	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.92962663
97	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.91078497
98	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.90716346
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89047238
100	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.88572129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	5.59157080
2	MP0003136_yellow_coat_color	4.14945901
3	MP0006292_abnormal_olfactory_placode	4.07586407
4	MP0003011_delayed_dark_adaptation	3.56685029
5	MP0005253_abnormal_eye_physiology	3.30560472
6	MP0004147_increased_porphyrin_level	2.88936158
7	MP0005551_abnormal_eye_electrophysiolog	2.85882457
8	MP0003195_calcinosis	2.52489327
9	MP0003806_abnormal_nucleotide_metabolis	2.50595935
10	MP0005085_abnormal_gallbladder_physiolo	2.44197342
11	MP0002876_abnormal_thyroid_physiology	2.25020747
12	MP0004043_abnormal_pH_regulation	2.12970909
13	MP0003172_abnormal_lysosome_physiology	2.09827196
14	MP0001293_anophthalmia	2.08963064
15	MP0003656_abnormal_erythrocyte_physiolo	2.07468939
16	MP0003646_muscle_fatigue	1.94752225
17	MP0005365_abnormal_bile_salt	1.90903104
18	MP0005248_abnormal_Harderian_gland	1.89338976
19	MP0005391_vision/eye_phenotype	1.87845001
20	MP0005257_abnormal_intraocular_pressure	1.79708347
21	MP0008995_early_reproductive_senescence	1.74267276
22	MP0005671_abnormal_response_to	1.57805471
23	MP0010234_abnormal_vibrissa_follicle	1.56109569
24	MP0005195_abnormal_posterior_eye	1.55457887
25	MP0000427_abnormal_hair_cycle	1.49314312
26	MP0004270_analgesia	1.45411147
27	MP0010329_abnormal_lipoprotein_level	1.41219044
28	MP0002822_catalepsy	1.40047948
29	MP0002138_abnormal_hepatobiliary_system	1.38747423
30	MP0002095_abnormal_skin_pigmentation	1.38529981
31	MP0000681_abnormal_thyroid_gland	1.37245947
32	MP0009745_abnormal_behavioral_response	1.33797820
33	MP0005377_hearing/vestibular/ear_phenot	1.33323483
34	MP0003878_abnormal_ear_physiology	1.33323483
35	MP0000569_abnormal_digit_pigmentation	1.33095844
36	MP0002090_abnormal_vision	1.32787659
37	MP0000631_abnormal_neuroendocrine_gland	1.31793014
38	MP0002139_abnormal_hepatobiliary_system	1.30318226
39	MP0005670_abnormal_white_adipose	1.29130001
40	MP0005646_abnormal_pituitary_gland	1.26671993
41	MP0005075_abnormal_melanosome_morpholog	1.24360674
42	MP0001764_abnormal_homeostasis	1.23465583
43	MP0001270_distended_abdomen	1.19848618
44	MP0005084_abnormal_gallbladder_morpholo	1.19758248
45	MP0002102_abnormal_ear_morphology	1.18951694
46	MP0002067_abnormal_sensory_capabilities	1.18571936
47	MP0000613_abnormal_salivary_gland	1.18299986
48	MP0001790_abnormal_immune_system	1.16931487
49	MP0005387_immune_system_phenotype	1.16931487
50	MP0001963_abnormal_hearing_physiology	1.11453108
51	MP0002733_abnormal_thermal_nociception	1.08954275
52	MP0002229_neurodegeneration	1.08716023
53	MP0005367_renal/urinary_system_phenotyp	1.08187127
54	MP0000516_abnormal_urinary_system	1.08187127
55	MP0003635_abnormal_synaptic_transmissio	1.07920175
56	MP0001835_abnormal_antigen_presentation	1.06192103
57	MP0009046_muscle_twitch	1.05363133
58	MP0005647_abnormal_sex_gland	1.04810304
59	MP0008875_abnormal_xenobiotic_pharmacok	1.03160338
60	MP0000647_abnormal_sebaceous_gland	1.02350265
61	MP0003252_abnormal_bile_duct	1.02302757
62	MP0002332_abnormal_exercise_endurance	1.00509721
63	MP0006054_spinal_hemorrhage	1.00240292
64	MP0005332_abnormal_amino_acid	0.99717560
65	MP0000685_abnormal_immune_system	0.98209275
66	MP0000538_abnormal_urinary_bladder	0.98012351
67	MP0003638_abnormal_response/metabolism_	0.97476508
68	MP0001485_abnormal_pinna_reflex	0.97318461
69	MP0001324_abnormal_eye_pigmentation	0.93798748
70	MP0001661_extended_life_span	0.93670380
71	MP0005379_endocrine/exocrine_gland_phen	0.92563100
72	MP0002638_abnormal_pupillary_reflex	0.91327732
73	MP0003718_maternal_effect	0.91086826
74	MP0001286_abnormal_eye_development	0.90408878
75	MP0001968_abnormal_touch/_nociception	0.89339611
76	MP0002572_abnormal_emotion/affect_behav	0.87731312
77	MP0001970_abnormal_pain_threshold	0.86821785
78	MP0001486_abnormal_startle_reflex	0.85784118
79	MP0000371_diluted_coat_color	0.85397857
80	MP0002160_abnormal_reproductive_system	0.84069351
81	MP0003567_abnormal_fetal_cardiomyocyte	0.84032230
82	MP0001666_abnormal_nutrient_absorption	0.82871176
83	MP0005187_abnormal_penis_morphology	0.81430393
84	MP0002837_dystrophic_cardiac_calcinosis	0.81289635
85	MP0003183_abnormal_peptide_metabolism	0.81256986
86	MP0002752_abnormal_somatic_nervous	0.80511960
87	MP0003879_abnormal_hair_cell	0.78631750
88	MP0005174_abnormal_tail_pigmentation	0.77731014
89	MP0000465_gastrointestinal_hemorrhage	0.76134936
90	MP0002092_abnormal_eye_morphology	0.75735113
91	MP0002734_abnormal_mechanical_nocicepti	0.75301186
92	MP0003755_abnormal_palate_morphology	0.75069574
93	MP0005167_abnormal_blood-brain_barrier	0.74767529
94	MP0001145_abnormal_male_reproductive	0.74489217
95	MP0000639_abnormal_adrenal_gland	0.74171129
96	MP0008057_abnormal_DNA_replication	0.73726667
97	MP0005220_abnormal_exocrine_pancreas	0.73688248
98	MP0005266_abnormal_metabolism	0.72512040
99	MP0010386_abnormal_urinary_bladder	0.71583284
100	MP0000372_irregular_coat_pigmentation	0.71064072

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	8.32399552
2	Agammaglobulinemia (HP:0004432)	6.46679425
3	Supernumerary spleens (HP:0009799)	6.42192184
4	Persistence of primary teeth (HP:0006335)	5.62269777
5	Progressive external ophthalmoplegia (HP:0000590)	5.61254316
6	Abnormality of the proximal phalanges of the hand (HP:0009834)	5.36836392
7	Chronic sinusitis (HP:0011109)	4.93869375
8	Delayed CNS myelination (HP:0002188)	4.52096836
9	Abnormality of the middle phalanges of the toes (HP:0010183)	4.38865943
10	Proximal tubulopathy (HP:0000114)	4.08332538
11	Hydroureter (HP:0000072)	4.04042812
12	Protruding tongue (HP:0010808)	3.62481270
13	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.32130766
14	Flared iliac wings (HP:0002869)	3.16350379
15	Recurrent bronchitis (HP:0002837)	3.09773555
16	Nephronophthisis (HP:0000090)	3.09321430
17	Medial flaring of the eyebrow (HP:0010747)	3.04426670
18	Prostate neoplasm (HP:0100787)	3.02315561
19	Coronal craniosynostosis (HP:0004440)	2.98146093
20	Hyperglycinemia (HP:0002154)	2.93052640
21	Renal cortical cysts (HP:0000803)	2.85825044
22	Congenital, generalized hypertrichosis (HP:0004540)	2.80988044
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76882104
24	Verrucae (HP:0200043)	2.69516740
25	Papilloma (HP:0012740)	2.69516740
26	Pulmonary artery stenosis (HP:0004415)	2.68769511
27	Abnormality of the prostate (HP:0008775)	2.64541540
28	Methylmalonic acidemia (HP:0002912)	2.58663538
29	Abnormality of the renal medulla (HP:0100957)	2.56069769
30	Torticollis (HP:0000473)	2.41553522
31	Cellulitis (HP:0100658)	2.38640219
32	Tubulointerstitial nephritis (HP:0001970)	2.36469802
33	Glucose intolerance (HP:0000833)	2.35630565
34	External ophthalmoplegia (HP:0000544)	2.33362791
35	Preauricular pit (HP:0004467)	2.32758084
36	Periauricular skin pits (HP:0100277)	2.32758084
37	Recurrent pneumonia (HP:0006532)	2.32174517
38	Abnormality of the renal cortex (HP:0011035)	2.31986758
39	Azoospermia (HP:0000027)	2.27788426
40	Hemiparesis (HP:0001269)	2.24210482
41	Transposition of the great arteries (HP:0001669)	2.23471275
42	Abnormal connection of the cardiac segments (HP:0011545)	2.23471275
43	Abnormal ventriculo-arterial connection (HP:0011563)	2.23471275
44	Septo-optic dysplasia (HP:0100842)	2.22284509
45	Spinal canal stenosis (HP:0003416)	2.22045281
46	Abnormality of the phalanges of the hallux (HP:0010057)	2.21322409
47	Clumsiness (HP:0002312)	2.17992099
48	Palpebral edema (HP:0100540)	2.15955229
49	Annular pancreas (HP:0001734)	2.14359729
50	Deep palmar crease (HP:0006191)	2.08774960
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.04803772
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.04803772
53	Abnormal spermatogenesis (HP:0008669)	2.04668918
54	Hypokinesia (HP:0002375)	1.98847662
55	Double outlet right ventricle (HP:0001719)	1.98530681
56	Congenital malformation of the right heart (HP:0011723)	1.98530681
57	Abnormality of serine family amino acid metabolism (HP:0010894)	1.95682942
58	Abnormality of glycine metabolism (HP:0010895)	1.95682942
59	Posterior subcapsular cataract (HP:0007787)	1.95638645
60	Duplication of thumb phalanx (HP:0009942)	1.95416242
61	Fibular hypoplasia (HP:0003038)	1.93613288
62	Sepsis (HP:0100806)	1.93341872
63	Abnormality of midbrain morphology (HP:0002418)	1.92691277
64	Molar tooth sign on MRI (HP:0002419)	1.92691277
65	Asplenia (HP:0001746)	1.92677112
66	Hyperlipoproteinemia (HP:0010980)	1.92671186
67	Nausea (HP:0002018)	1.91719990
68	Neonatal respiratory distress (HP:0002643)	1.91378958
69	Pancreatic cysts (HP:0001737)	1.91333510
70	Hypoplasia of the fovea (HP:0007750)	1.90713740
71	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.90713740
72	Natal tooth (HP:0000695)	1.86599257
73	Poor eye contact (HP:0000817)	1.86558695
74	Congenital primary aphakia (HP:0007707)	1.86089456
75	Gait imbalance (HP:0002141)	1.84070002
76	Dysphonia (HP:0001618)	1.81730241
77	Adrenal hypoplasia (HP:0000835)	1.81053921
78	Abolished electroretinogram (ERG) (HP:0000550)	1.81023135
79	Abnormality of the wing of the ilium (HP:0011867)	1.80619129
80	Abnormal glucose tolerance (HP:0001952)	1.79136683
81	Bronchomalacia (HP:0002780)	1.77688834
82	Hypoglycemic coma (HP:0001325)	1.77405828
83	Tracheomalacia (HP:0002779)	1.75887903
84	Abnormality of the renal collecting system (HP:0004742)	1.75427864
85	Abnormality of secondary sexual hair (HP:0009888)	1.74862304
86	Abnormality of the axillary hair (HP:0100134)	1.74862304
87	Osteomyelitis (HP:0002754)	1.73303598
88	Abnormality of the fovea (HP:0000493)	1.72160678
89	Abnormality of vitamin B metabolism (HP:0004340)	1.70458658
90	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69159436
91	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.68541301
92	Stage 5 chronic kidney disease (HP:0003774)	1.67347776
93	Hypoplastic nipples (HP:0002557)	1.67106869
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.67055951
95	Vaginal atresia (HP:0000148)	1.65741519
96	Arthropathy (HP:0003040)	1.63970907
97	Preaxial foot polydactyly (HP:0001841)	1.62469135
98	Hemiplegia (HP:0002301)	1.61146751
99	Hepatic necrosis (HP:0002605)	1.61023764
100	Macroglossia (HP:0000158)	1.59833744

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	5.48848664
2	FRK	2.79380113
3	WNK4	2.35420917
4	EIF2AK1	2.06108516
5	TESK2	12.6010227
6	EIF2AK3	1.99720913
7	SIK3	1.95849736
8	FGFR2	1.70512131
9	ACVR1B	1.64947755
10	STK39	1.61902021
11	CDK19	1.48400204
12	MAP3K13	1.43438870
13	CAMKK2	1.41227911
14	BRSK2	1.38184889
15	CASK	1.33886672
16	STK38L	1.21540829
17	MAPKAPK3	1.21105802
18	SIK2	1.13185726
19	PIK3CG	1.10482995
20	ZAK	1.10428151
21	MAP3K9	1.09558345
22	WNK3	1.08545519
23	NTRK2	0.97403618
24	CAMK2B	0.97065284
25	ICK	0.94580166
26	CCNB1	0.89755852
27	CSNK1G3	0.84933851
28	OXSR1	0.80400756
29	CAMKK1	0.80279425
30	MOS	0.75311820
31	ITK	0.73837283
32	CSNK1G2	0.73056661
33	BCR	0.72365212
34	STK24	0.70495924
35	CSNK1G1	0.65783528
36	CSNK1A1L	0.62751724
37	AKT3	0.58437030
38	INSRR	0.57460298
39	STK16	0.57168263
40	GRK7	0.57110424
41	TYK2	0.54983937
42	SYK	0.54799291
43	SIK1	0.54310859
44	STK3	0.53666295
45	BCKDK	0.52569985
46	FGFR3	0.52530658
47	MARK3	0.52529030
48	CAMK2D	0.52259950
49	CAMK2G	0.47956208
50	TRIM28	0.47528523
51	LYN	0.45746340
52	MARK2	0.45216042
53	BRSK1	0.44725926
54	DYRK1B	0.44332468
55	TAOK1	0.40019905
56	PHKG2	0.38826905
57	PHKG1	0.38826905
58	PIK3CA	0.37534550
59	PINK1	0.37034896
60	MAPK7	0.36943244
61	ARAF	0.36348809
62	STK11	0.35979199
63	MST4	0.32437634
64	TYRO3	0.32067370
65	STK10	0.30286994
66	ADRBK2	0.29466775
67	YES1	0.29424174
68	DAPK1	0.28487468
69	TRPM7	0.28464083
70	CAMK2A	0.28355551
71	CSF1R	0.28231478
72	EPHA4	0.26246747
73	IGF1R	0.25968318
74	MAPK11	0.25504103
75	WNK1	0.24200625
76	SRPK1	0.24176481
77	PRKACG	0.23452876
78	PRKACA	0.21190704
79	PRKCQ	0.20931710
80	TNK2	0.20436537
81	MAPK12	0.19865467
82	PRKAA2	0.19156166
83	PRKAA1	0.19154412
84	CDK6	0.19113512
85	NTRK3	0.19063879
86	PRKCE	0.18632268
87	KIT	0.17355021
88	PRKD2	0.16958667
89	PLK2	0.16692919
90	PTK2B	0.15485079
91	TGFBR2	0.15452147
92	PRKD1	0.15011431
93	ADRBK1	0.14939406
94	CSNK1A1	0.14152424
95	MAP2K6	0.14060100
96	MAP3K4	0.13566341
97	LCK	0.13003881
98	FYN	0.12305731
99	BMPR2	0.11742139
100	PRKCI	0.11325361

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	5.42638967
2	Asthma_Homo sapiens_hsa05310	3.71424326
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.13850630
4	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.75729477
5	Propanoate metabolism_Homo sapiens_hsa00640	2.72744204
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.34715037
7	Protein export_Homo sapiens_hsa03060	2.21056193
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.20762969
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.16983754
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.10582890
11	Allograft rejection_Homo sapiens_hsa05330	2.06899934
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.06424051
13	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.04356987
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.02600935
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.97877819
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89422011
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.67138028
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.63624246
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58889930
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56379626
21	Retinol metabolism_Homo sapiens_hsa00830	1.43612233
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.42456968
23	Taste transduction_Homo sapiens_hsa04742	1.26200494
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23393294
25	Histidine metabolism_Homo sapiens_hsa00340	1.22459859
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.21182684
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.15521935
28	ABC transporters_Homo sapiens_hsa02010	1.14746689
29	Viral myocarditis_Homo sapiens_hsa05416	1.14214986
30	p53 signaling pathway_Homo sapiens_hsa04115	1.09246590
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.09018941
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.08602435
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07175889
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06211595
35	Butanoate metabolism_Homo sapiens_hsa00650	1.04383970
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04349856
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.04086978
38	Peroxisome_Homo sapiens_hsa04146	1.00803448
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00469271
40	Serotonergic synapse_Homo sapiens_hsa04726	0.98665517
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98259328
42	GABAergic synapse_Homo sapiens_hsa04727	0.97715917
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97374512
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.96727807
45	Circadian entrainment_Homo sapiens_hsa04713	0.94765137
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94709358
47	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.94645598
48	Morphine addiction_Homo sapiens_hsa05032	0.93643592
49	Nicotine addiction_Homo sapiens_hsa05033	0.92915565
50	Complement and coagulation cascades_Homo sapiens_hsa04610	0.92753290
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91772111
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91247755
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.90039702
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.89797099
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89673187
56	One carbon pool by folate_Homo sapiens_hsa00670	0.88974002
57	Olfactory transduction_Homo sapiens_hsa04740	0.87691627
58	Regulation of autophagy_Homo sapiens_hsa04140	0.81201370
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80397648
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80222585
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79634018
62	Salivary secretion_Homo sapiens_hsa04970	0.75666827
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75038289
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.72856344
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.70927066
66	Circadian rhythm_Homo sapiens_hsa04710	0.70722427
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70689293
68	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.67154945
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.66680824
70	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.66502611
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64017088
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63572910
73	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.61479559
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58844054
75	Gastric acid secretion_Homo sapiens_hsa04971	0.56619942
76	Insulin secretion_Homo sapiens_hsa04911	0.53712024
77	Sulfur metabolism_Homo sapiens_hsa00920	0.53485960
78	Metabolic pathways_Homo sapiens_hsa01100	0.52025424
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.51848849
80	Cocaine addiction_Homo sapiens_hsa05030	0.50456601
81	Purine metabolism_Homo sapiens_hsa00230	0.49220629
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.46384197
83	Homologous recombination_Homo sapiens_hsa03440	0.46125594
84	Cholinergic synapse_Homo sapiens_hsa04725	0.45729140
85	RNA polymerase_Homo sapiens_hsa03020	0.44630314
86	Oxidative phosphorylation_Homo sapiens_hsa00190	0.42952804
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42669060
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.42069105
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40983877
90	African trypanosomiasis_Homo sapiens_hsa05143	0.39212905
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38439826
92	Bile secretion_Homo sapiens_hsa04976	0.37791643
93	Parkinsons disease_Homo sapiens_hsa05012	0.35090483
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.31996962
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.31781454
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31143873
97	RNA degradation_Homo sapiens_hsa03018	0.30211370
98	Amphetamine addiction_Homo sapiens_hsa05031	0.28908263
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28040140
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.27256862

GXYLT1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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