GXYLT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a xylosyltransferase that elongates O-linked glucose bound to epidermal growth factor (EGF) repeats. The encoded protein catalyzes the addition of xylose to the O-glucose-modified residues of EGF repeats of Notch proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)5.26560609
2bone trabecula formation (GO:0060346)5.07121689
3chondrocyte proliferation (GO:0035988)5.02756470
4collagen fibril organization (GO:0030199)4.94751169
5protein heterotrimerization (GO:0070208)4.54229628
6sequestering of extracellular ligand from receptor (GO:0035581)4.12179007
7mesenchymal-epithelial cell signaling (GO:0060638)3.99042260
8metanephric mesenchyme development (GO:0072075)3.96652495
9peptidyl-proline hydroxylation (GO:0019511)3.83933458
10otic vesicle formation (GO:0030916)3.79771642
11kidney mesenchyme development (GO:0072074)3.71783545
12extracellular negative regulation of signal transduction (GO:1900116)3.60026509
13extracellular regulation of signal transduction (GO:1900115)3.60026509
14collagen catabolic process (GO:0030574)3.55580709
15chondrocyte development (GO:0002063)3.53797194
16mesenchymal cell differentiation involved in kidney development (GO:0072161)3.52728014
17mesenchymal cell differentiation involved in renal system development (GO:2001012)3.52728014
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.51932908
19axon extension involved in axon guidance (GO:0048846)3.51932908
20regulation of non-canonical Wnt signaling pathway (GO:2000050)3.49768653
21regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.48230569
22organ induction (GO:0001759)3.47557362
23collagen metabolic process (GO:0032963)3.47315736
24response to pheromone (GO:0019236)3.41394762
25protein localization to cell surface (GO:0034394)3.40867476
26embryonic cranial skeleton morphogenesis (GO:0048701)3.40110739
27genitalia morphogenesis (GO:0035112)3.37731634
28keratan sulfate biosynthetic process (GO:0018146)3.30580888
29dermatan sulfate biosynthetic process (GO:0030208)3.28414399
30craniofacial suture morphogenesis (GO:0097094)3.27220010
31multicellular organismal macromolecule metabolic process (GO:0044259)3.25030571
32multicellular organismal catabolic process (GO:0044243)3.20806144
33phosphate ion homeostasis (GO:0055062)3.19404189
34trivalent inorganic anion homeostasis (GO:0072506)3.19404189
35regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.16098313
36kidney morphogenesis (GO:0060993)3.14125367
37regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.11933499
38lateral sprouting from an epithelium (GO:0060601)3.11037453
39extracellular matrix assembly (GO:0085029)3.10774593
40positive regulation of osteoblast proliferation (GO:0033690)3.09171742
41dermatan sulfate metabolic process (GO:0030205)3.09005161
42response to redox state (GO:0051775)3.07870920
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06720900
44retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05800780
45limb bud formation (GO:0060174)3.04875170
46embryonic forelimb morphogenesis (GO:0035115)3.04239523
47mesenchymal cell differentiation (GO:0048762)3.04194728
48pericardium development (GO:0060039)3.03046712
49artery development (GO:0060840)3.02895848
50multicellular organismal metabolic process (GO:0044236)3.02075385
51extracellular fibril organization (GO:0043206)3.01873008
52protein hydroxylation (GO:0018126)3.01631594
53smooth muscle tissue development (GO:0048745)3.01058630
54outer ear morphogenesis (GO:0042473)3.00694668
55regulation of mesenchymal cell proliferation (GO:0010464)2.99653597
56organ formation (GO:0048645)2.99470009
57lung secretory cell differentiation (GO:0061140)2.98263901
58regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97653674
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95788190
60positive regulation of mesenchymal cell proliferation (GO:0002053)2.95295937
61positive regulation of cardiac muscle hypertrophy (GO:0010613)2.95274503
62positive regulation of muscle hypertrophy (GO:0014742)2.95274503
63muscle cell fate commitment (GO:0042693)2.94709864
64endodermal cell differentiation (GO:0035987)2.93891747
65mesenchymal cell proliferation (GO:0010463)2.93688017
66negative regulation of stem cell proliferation (GO:2000647)2.91583726
67ganglion development (GO:0061548)2.91163481
68middle ear morphogenesis (GO:0042474)2.88254977
69face morphogenesis (GO:0060325)2.87941268
70import into cell (GO:0098657)2.87519263
71keratan sulfate metabolic process (GO:0042339)2.86962232
72extracellular matrix disassembly (GO:0022617)2.86216812
73COPII vesicle coating (GO:0048208)2.86196244
74mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.85676027
75regulation of organ formation (GO:0003156)2.83846615
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80347554
77negative regulation of chondrocyte differentiation (GO:0032331)2.77617554
78embryonic digestive tract morphogenesis (GO:0048557)2.76029117
79cranial nerve morphogenesis (GO:0021602)2.75554312
80cranial suture morphogenesis (GO:0060363)2.75168115
81cell proliferation involved in kidney development (GO:0072111)2.72467736
82negative regulation of axon extension involved in axon guidance (GO:0048843)2.71671838
83anterior/posterior axis specification, embryo (GO:0008595)2.71604258
84regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71573372
85head development (GO:0060322)2.71239745
86radial glial cell differentiation (GO:0060019)2.70927903
87regulation of osteoblast proliferation (GO:0033688)2.70474338
88forelimb morphogenesis (GO:0035136)2.70328371
89peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69235194
90cartilage morphogenesis (GO:0060536)2.69060450
91G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.66804129
92branching involved in salivary gland morphogenesis (GO:0060445)2.65524741
93mesonephros development (GO:0001823)2.65135310
94branching involved in prostate gland morphogenesis (GO:0060442)2.64289232
95negative regulation of myoblast differentiation (GO:0045662)2.63775016
96phospholipid homeostasis (GO:0055091)2.63041954
97negative regulation of axon guidance (GO:1902668)2.62901803
98negative regulation of leukocyte chemotaxis (GO:0002689)2.61659749
99negative regulation of lipase activity (GO:0060192)2.60788607
100regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59705954
101negative regulation of embryonic development (GO:0045992)2.59536643
102glomerular basement membrane development (GO:0032836)2.58308559
103water-soluble vitamin biosynthetic process (GO:0042364)2.57939654
104positive regulation of smoothened signaling pathway (GO:0045880)2.57555120
105bone remodeling (GO:0046849)2.57317863
106extracellular matrix organization (GO:0030198)2.57099658
107extracellular structure organization (GO:0043062)2.56281259
108regulation of acyl-CoA biosynthetic process (GO:0050812)2.54999952
109nephron epithelium morphogenesis (GO:0072088)2.54566268
110nephron tubule morphogenesis (GO:0072078)2.54566268
111branch elongation of an epithelium (GO:0060602)2.54565210
112protein K6-linked ubiquitination (GO:0085020)2.54356231
113white fat cell differentiation (GO:0050872)2.52639556
114regulation of cardiac muscle hypertrophy (GO:0010611)2.51475154
115platelet dense granule organization (GO:0060155)2.51222042
116prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.51041337
117neural crest cell development (GO:0014032)2.50568357
118embryonic skeletal system morphogenesis (GO:0048704)2.50103036
119negative regulation of osteoblast proliferation (GO:0033689)2.49908066
120negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.49702512
121toxin metabolic process (GO:0009404)2.49401051
122embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48416169
123skin morphogenesis (GO:0043589)2.48126860
124negative chemotaxis (GO:0050919)2.47968071
125cell proliferation involved in metanephros development (GO:0072203)2.47908677
126mesodermal cell differentiation (GO:0048333)2.47881240
127positive regulation of fat cell differentiation (GO:0045600)2.47365463
128cochlea morphogenesis (GO:0090103)2.47155146
129detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46848940
130camera-type eye morphogenesis (GO:0048593)2.46664596
131negative regulation of keratinocyte proliferation (GO:0010839)2.46280162
132somite development (GO:0061053)2.45933744
133female gonad development (GO:0008585)2.45527632
134platelet-derived growth factor receptor signaling pathway (GO:0048008)2.44557925
135cellular response to vitamin D (GO:0071305)2.44446322
136regulation of transforming growth factor beta2 production (GO:0032909)2.43923370
137regulation of keratinocyte proliferation (GO:0010837)2.43871149
138regulation of muscle hypertrophy (GO:0014743)2.43599534
139axon ensheathment in central nervous system (GO:0032291)2.42838636
140central nervous system myelination (GO:0022010)2.42838636
141GMP metabolic process (GO:0046037)2.42775401
142cerebral cortex radially oriented cell migration (GO:0021799)2.42567523
143fibril organization (GO:0097435)2.42560638
144cell migration involved in heart development (GO:0060973)2.42259117
145bone morphogenesis (GO:0060349)2.41832100
146reverse cholesterol transport (GO:0043691)2.41716607
147skeletal system development (GO:0001501)2.41064873
148mesenchyme morphogenesis (GO:0072132)2.40920215
149regulation of meiosis I (GO:0060631)2.40416191
150lung vasculature development (GO:0060426)2.40154541
151embryonic digit morphogenesis (GO:0042733)2.39222063
152anatomical structure arrangement (GO:0048532)2.39073330
153regulation of interleukin-8 secretion (GO:2000482)2.38657114
154regulation of integrin-mediated signaling pathway (GO:2001044)2.35021483
155positive regulation of meiosis (GO:0045836)2.33648560
156regulation of hippo signaling (GO:0035330)2.32237710
157high-density lipoprotein particle remodeling (GO:0034375)2.31394595
158negative regulation of sodium ion transport (GO:0010766)2.30161315
159renal tubule morphogenesis (GO:0061333)2.29931578
160regulation of sulfur metabolic process (GO:0042762)2.29155091
161prostate gland growth (GO:0060736)2.28564981
162embryonic camera-type eye development (GO:0031076)2.28156215
163regulation of chondrocyte differentiation (GO:0032330)2.26611030
164cellular ketone body metabolic process (GO:0046950)2.24082107
165proteasome assembly (GO:0043248)2.23204572
166positive regulation of receptor internalization (GO:0002092)2.23169675
167determination of left/right symmetry (GO:0007368)2.22936481
168regulation of cardioblast differentiation (GO:0051890)2.20311118
169replicative senescence (GO:0090399)2.18446363
170mammary gland development (GO:0030879)2.17756575
171regulation of cytokine secretion involved in immune response (GO:0002739)2.17393797
172determination of bilateral symmetry (GO:0009855)2.16658640
173negative regulation of BMP signaling pathway (GO:0030514)2.16144730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.19880066
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18764900
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.01485673
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.69518680
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.48372204
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.42433231
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34969734
8ZNF274_21170338_ChIP-Seq_K562_Hela2.29229507
9EZH2_22144423_ChIP-Seq_EOC_Human2.23613086
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13680689
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.12748005
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12366457
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10829719
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09996698
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04273277
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04273277
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.03403520
18* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.03397455
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02038720
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02006504
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01699683
22VDR_22108803_ChIP-Seq_LS180_Human1.96815318
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.93016268
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92256975
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.90923487
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90872755
27SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87617488
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87364552
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84826441
30TP53_18474530_ChIP-ChIP_U2OS_Human1.81751816
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.81664700
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76903514
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76741972
34* CJUN_26792858_Chip-Seq_BT549_Human1.75927535
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75434030
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75396316
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74795684
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.73214939
39TP53_16413492_ChIP-PET_HCT116_Human1.71412164
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71363013
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.67689680
42IGF1R_20145208_ChIP-Seq_DFB_Human1.65316863
43AR_21572438_ChIP-Seq_LNCaP_Human1.63227081
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62537311
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62272638
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60847309
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59862429
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.57354119
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54606764
50BCAT_22108803_ChIP-Seq_LS180_Human1.52254384
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50543186
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50312285
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50167994
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50167994
55P300_19829295_ChIP-Seq_ESCs_Human1.48731910
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47824664
57ER_23166858_ChIP-Seq_MCF-7_Human1.46775859
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.45166655
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.43158191
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.42617219
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41848129
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41496450
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40445251
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38961045
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37894615
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.36918799
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36228052
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.34785148
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.34504943
70TCF4_23295773_ChIP-Seq_U87_Human1.33792882
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.32104697
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30960243
73* CDX2_22108803_ChIP-Seq_LS180_Human1.30548237
74AR_25329375_ChIP-Seq_VCAP_Human1.30074709
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.29686997
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.29634804
77SMAD4_21799915_ChIP-Seq_A2780_Human1.29132246
78TAF15_26573619_Chip-Seq_HEK293_Human1.27920204
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27594720
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27348583
81RNF2_27304074_Chip-Seq_NSC_Mouse1.27133569
82FUS_26573619_Chip-Seq_HEK293_Human1.26852906
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24356652
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24101589
85EWS_26573619_Chip-Seq_HEK293_Human1.23716649
86ELK1_19687146_ChIP-ChIP_HELA_Human1.23602187
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23114317
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22434507
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.22309508
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21579917
91CBP_20019798_ChIP-Seq_JUKART_Human1.21579917
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21379357
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19483885
94P53_22387025_ChIP-Seq_ESCs_Mouse1.19270798
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.19066877
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19020094
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18157444
98TCF4_22108803_ChIP-Seq_LS180_Human1.18003834
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17974580
100* NANOG_19829295_ChIP-Seq_ESCs_Human1.16711288
101* SOX2_19829295_ChIP-Seq_ESCs_Human1.16711288
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.16133338
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15909675
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12843157
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12701386
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.12662407
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12109233
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11203373
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11134001
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.10894764
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10649792
112BRD4_25478319_ChIP-Seq_HGPS_Human1.09206129
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08897306
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08727256
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08635328
116STAT3_23295773_ChIP-Seq_U87_Human1.08408744
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.07374565
118KDM2B_26808549_Chip-Seq_REH_Human1.06622422
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06449970
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06332985
121AHR_22903824_ChIP-Seq_MCF-7_Human1.06220096
122CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06105573
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05306321
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.04716175
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04266677
126P300_18555785_Chip-Seq_ESCs_Mouse1.04030313
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03453206
128IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03019868
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.02727453
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.02309221
131OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99095544
132SOX2_18555785_Chip-Seq_ESCs_Mouse0.98037680
133LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96181311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.60728855
2MP0005503_abnormal_tendon_morphology5.61708464
3MP0005257_abnormal_intraocular_pressure4.02028801
4MP0005275_abnormal_skin_tensile3.95900249
5MP0000566_synostosis3.80923778
6MP0009250_abnormal_appendicular_skeleto2.99342840
7MP0005623_abnormal_meninges_morphology2.47121956
8MP0005171_absent_coat_pigmentation2.38945302
9MP0001958_emphysema2.37319388
10MP0005508_abnormal_skeleton_morphology2.35865696
11MP0003279_aneurysm2.31102742
12MP0003385_abnormal_body_wall2.28797549
13MP0001299_abnormal_eye_distance/2.20397961
14MP0009384_cardiac_valve_regurgitation2.19854392
15MP0004134_abnormal_chest_morphology1.91799493
16MP0001661_extended_life_span1.85272648
17MP0004272_abnormal_basement_membrane1.84174101
18MP0000049_abnormal_middle_ear1.84063690
19MP0001346_abnormal_lacrimal_gland1.83718479
20MP0002876_abnormal_thyroid_physiology1.83319658
21MP0003937_abnormal_limbs/digits/tail_de1.82121968
22MP0003941_abnormal_skin_development1.75939294
23MP0010030_abnormal_orbit_morphology1.75457718
24MP0001542_abnormal_bone_strength1.72034503
25MP0002108_abnormal_muscle_morphology1.71149165
26MP0002060_abnormal_skin_morphology1.68032134
27MP0003755_abnormal_palate_morphology1.59291745
28MP0002896_abnormal_bone_mineralization1.56465205
29MP0002249_abnormal_larynx_morphology1.56244368
30MP0000013_abnormal_adipose_tissue1.50202319
31MP0002115_abnormal_skeleton_extremities1.48401728
32MP0000163_abnormal_cartilage_morphology1.48323792
33MP0002233_abnormal_nose_morphology1.46237512
34MP0000428_abnormal_craniofacial_morphol1.45305848
35MP0000762_abnormal_tongue_morphology1.44733191
36MP0006072_abnormal_retinal_apoptosis1.44002146
37MP0002116_abnormal_craniofacial_bone1.41777681
38MP0002938_white_spotting1.40831815
39MP0002295_abnormal_pulmonary_circulatio1.39071804
40MP0000432_abnormal_head_morphology1.39001939
41MP0002109_abnormal_limb_morphology1.38295490
42MP0001188_hyperpigmentation1.38124894
43MP0002113_abnormal_skeleton_development1.35772030
44MP0002932_abnormal_joint_morphology1.35187942
45MP0003283_abnormal_digestive_organ1.35056277
46MP0002102_abnormal_ear_morphology1.33416239
47MP0000733_abnormal_muscle_development1.31615250
48MP0002163_abnormal_gland_morphology1.31208209
49MP0000569_abnormal_digit_pigmentation1.30250575
50MP0003942_abnormal_urinary_system1.28359811
51MP0005390_skeleton_phenotype1.27949573
52MP0008877_abnormal_DNA_methylation1.27892715
53MP0002998_abnormal_bone_remodeling1.25793168
54MP0002177_abnormal_outer_ear1.24599051
55MP0000534_abnormal_ureter_morphology1.23724302
56MP0003195_calcinosis1.22677044
57MP0002933_joint_inflammation1.19700919
58MP0005253_abnormal_eye_physiology1.19425026
59MP0002254_reproductive_system_inflammat1.18465988
60MP0002160_abnormal_reproductive_system1.18426153
61MP0003950_abnormal_plasma_membrane1.18048197
62MP0001986_abnormal_taste_sensitivity1.15520627
63MP0003935_abnormal_craniofacial_develop1.14743120
64MP0002234_abnormal_pharynx_morphology1.12989865
65MP0003938_abnormal_ear_development1.12823063
66MP0000767_abnormal_smooth_muscle1.07357709
67MP0003045_fibrosis1.06466874
68MP0009053_abnormal_anal_canal1.06312415
69MP0002282_abnormal_trachea_morphology1.05303301
70MP0003136_yellow_coat_color1.04208099
71MP0005197_abnormal_uvea_morphology1.02675826
72MP0000613_abnormal_salivary_gland1.02190058
73MP0002114_abnormal_axial_skeleton1.00400800
74MP0005084_abnormal_gallbladder_morpholo0.98918365
75MP0003091_abnormal_cell_migration0.98506967
76MP0006054_spinal_hemorrhage0.98117253
77MP0002697_abnormal_eye_size0.94431236
78MP0004133_heterotaxia0.93477999
79MP0005367_renal/urinary_system_phenotyp0.93134193
80MP0000516_abnormal_urinary_system0.93134193
81MP0006292_abnormal_olfactory_placode0.91267961
82MP0005408_hypopigmentation0.90260938
83MP0009697_abnormal_copulation0.89310146
84MP0001243_abnormal_dermal_layer0.86792837
85MP0005551_abnormal_eye_electrophysiolog0.86199000
86MP0003795_abnormal_bone_structure0.86084002
87MP0000579_abnormal_nail_morphology0.85196564
88MP0002277_abnormal_respiratory_mucosa0.84609700
89MP0000427_abnormal_hair_cycle0.84337584
90MP0002111_abnormal_tail_morphology0.82977422
91MP0002837_dystrophic_cardiac_calcinosis0.81822144
92MP0004215_abnormal_myocardial_fiber0.80091962
93MP0010386_abnormal_urinary_bladder0.79950039
94MP0003122_maternal_imprinting0.79863347
95MP0000639_abnormal_adrenal_gland0.79589506
96MP0004084_abnormal_cardiac_muscle0.79461684
97MP0003119_abnormal_digestive_system0.78318904
98MP0001286_abnormal_eye_development0.77961351
99MP0008057_abnormal_DNA_replication0.77880420
100MP0010329_abnormal_lipoprotein_level0.77442747
101MP0000749_muscle_degeneration0.76683094
102MP0003786_premature_aging0.76665930
103MP0010368_abnormal_lymphatic_system0.76563044
104MP0005174_abnormal_tail_pigmentation0.75698864
105MP0000383_abnormal_hair_follicle0.75535791
106MP0002168_other_aberrant_phenotype0.75476942
107MP0000462_abnormal_digestive_system0.74664205
108MP0003705_abnormal_hypodermis_morpholog0.74343289
109MP0004742_abnormal_vestibular_system0.73950178
110MP0003567_abnormal_fetal_cardiomyocyte0.73664653
111MP0000681_abnormal_thyroid_gland0.73518866
112MP0005389_reproductive_system_phenotype0.73230040
113MP0003936_abnormal_reproductive_system0.71875615
114MP0005187_abnormal_penis_morphology0.70652588
115MP0000631_abnormal_neuroendocrine_gland0.70349125
116MP0000026_abnormal_inner_ear0.70134849
117MP0003252_abnormal_bile_duct0.70033637
118MP0001119_abnormal_female_reproductive0.68940555
119MP0002089_abnormal_postnatal_growth/wei0.68552689
120MP0003566_abnormal_cell_adhesion0.68262997
121MP0001879_abnormal_lymphatic_vessel0.68147721
122MP0003115_abnormal_respiratory_system0.67785856
123MP0004185_abnormal_adipocyte_glucose0.67163256
124MP0001177_atelectasis0.66405874
125MP0005391_vision/eye_phenotype0.66349185
126MP0002128_abnormal_blood_circulation0.65824304
127MP0001756_abnormal_urination0.65754527
128MP0005248_abnormal_Harderian_gland0.65115881
129MP0009780_abnormal_chondrocyte_physiolo0.64957797
130MP0005193_abnormal_anterior_eye0.64624781
131MP0001293_anophthalmia0.64371242
132MP0005220_abnormal_exocrine_pancreas0.63467330
133MP0002092_abnormal_eye_morphology0.63434724
134MP0005409_darkened_coat_color0.63390832
135MP0000647_abnormal_sebaceous_gland0.62895994
136MP0005023_abnormal_wound_healing0.62551535
137MP0005595_abnormal_vascular_smooth0.61888682
138MP0005379_endocrine/exocrine_gland_phen0.61839385
139MP0000372_irregular_coat_pigmentation0.61010680
140MP0000778_abnormal_nervous_system0.60505071
141MP0005388_respiratory_system_phenotype0.58429144
142MP0002133_abnormal_respiratory_system0.58429144

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.35609756
2Protrusio acetabuli (HP:0003179)5.77682581
3Metaphyseal dysplasia (HP:0100255)4.13809895
4Aortic dissection (HP:0002647)3.83648393
5Soft skin (HP:0000977)3.83118903
6Neonatal short-limb short stature (HP:0008921)3.61025397
7Broad metatarsal (HP:0001783)3.59941037
8Atrophic scars (HP:0001075)3.57518987
9Abnormality of dentin (HP:0010299)3.57219400
10Follicular hyperkeratosis (HP:0007502)3.52998524
11Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.33138592
12Shallow orbits (HP:0000586)3.30877648
13Ankle contracture (HP:0006466)3.22974965
14Bladder diverticulum (HP:0000015)3.08700669
15Short middle phalanx of the 5th finger (HP:0004220)3.07270574
16Fragile skin (HP:0001030)2.98933441
17Coronal craniosynostosis (HP:0004440)2.89862954
18Genu recurvatum (HP:0002816)2.76886281
19Cervical subluxation (HP:0003308)2.76051169
20Delayed closure of the anterior fontanelle (HP:0001476)2.73255681
21Vertebral compression fractures (HP:0002953)2.70891513
22Mesomelia (HP:0003027)2.70191041
23Bell-shaped thorax (HP:0001591)2.60682426
24Wormian bones (HP:0002645)2.59861681
25Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.56646799
26Aortic aneurysm (HP:0004942)2.54494626
27Subacute progressive viral hepatitis (HP:0006572)2.53425869
28Popliteal pterygium (HP:0009756)2.49393244
29Limited hip movement (HP:0008800)2.46941274
30Abnormality of incisor morphology (HP:0011063)2.43026139
31Morphological abnormality of the middle ear (HP:0008609)2.41932137
32Spinal cord lesions (HP:0100561)2.40925624
33Syringomyelia (HP:0003396)2.40925624
34Hypoalphalipoproteinemia (HP:0003233)2.40395184
35Peritonitis (HP:0002586)2.40164256
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.37321314
37Pulmonary artery stenosis (HP:0004415)2.36630048
38Pancreatic cysts (HP:0001737)2.36537351
39Spinal rigidity (HP:0003306)2.35187063
40Tibial bowing (HP:0002982)2.34468534
41Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.33783682
42Delayed cranial suture closure (HP:0000270)2.32534722
43Blue sclerae (HP:0000592)2.32302602
44Abnormality of the parietal bone (HP:0002696)2.31748451
45Wide anterior fontanel (HP:0000260)2.29223588
46Vascular tortuosity (HP:0004948)2.27124840
47Biconcave vertebral bodies (HP:0004586)2.21584611
48Femoral bowing (HP:0002980)2.21441954
49Microglossia (HP:0000171)2.20376034
50Small hand (HP:0200055)2.19772307
51Preaxial foot polydactyly (HP:0001841)2.19232093
52Aortic regurgitation (HP:0001659)2.19121364
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.19104748
54Broad ribs (HP:0000885)2.19095307
55Infantile muscular hypotonia (HP:0008947)2.18045626
56Hypoplasia of the iris (HP:0007676)2.16168768
57Delayed gross motor development (HP:0002194)2.15323292
58Dilatation of the ascending aorta (HP:0005111)2.13909520
59Type 1 muscle fiber predominance (HP:0003803)2.10746247
60Hypoplastic ischia (HP:0003175)2.08391539
61Long clavicles (HP:0000890)2.07296149
62Mild short stature (HP:0003502)2.07104799
63Joint laxity (HP:0001388)2.05414452
64True hermaphroditism (HP:0010459)2.04010434
65Craniofacial hyperostosis (HP:0004493)2.03955348
66Narrow palate (HP:0000189)2.03205522
67Abnormality of midbrain morphology (HP:0002418)2.02925399
68Molar tooth sign on MRI (HP:0002419)2.02925399
69Aplasia involving bones of the extremities (HP:0009825)2.02813214
70Aplasia involving bones of the upper limbs (HP:0009823)2.02813214
71Aplasia of the phalanges of the hand (HP:0009802)2.02813214
72Bifid tongue (HP:0010297)2.02284660
73Narrow nasal bridge (HP:0000446)2.01011248
74Persistence of primary teeth (HP:0006335)1.99786117
75Wrist flexion contracture (HP:0001239)1.99504649
76Hyperextensible skin (HP:0000974)1.98783830
77Spondylolisthesis (HP:0003302)1.98691130
78Mitral valve prolapse (HP:0001634)1.98453350
79Increased corneal curvature (HP:0100692)1.98332062
80Keratoconus (HP:0000563)1.98332062
81Increased number of teeth (HP:0011069)1.97258207
82Irregular vertebral endplates (HP:0003301)1.96807937
83Pancreatic fibrosis (HP:0100732)1.96494706
84Mitral regurgitation (HP:0001653)1.95963517
85Ulnar bowing (HP:0003031)1.94625328
86Slender build (HP:0001533)1.94142026
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.92101170
88Abnormal delivery (HP:0001787)1.90996959
89Patchy hypopigmentation of hair (HP:0011365)1.89784063
90Aplasia/Hypoplasia of the fibula (HP:0006492)1.89222487
91Recurrent corneal erosions (HP:0000495)1.88966513
92Elbow flexion contracture (HP:0002987)1.88823267
93Arthropathy (HP:0003040)1.87956646
94Fibular hypoplasia (HP:0003038)1.87890978
95Ectopic kidney (HP:0000086)1.87746760
96Conical tooth (HP:0000698)1.87490538
97Absent frontal sinuses (HP:0002688)1.86365820
98White forelock (HP:0002211)1.85924442
99Flared iliac wings (HP:0002869)1.84967497
100Chronic hepatic failure (HP:0100626)1.84928643
101Upper limb muscle weakness (HP:0003484)1.84095785
102Short tibia (HP:0005736)1.84002418
103Abnormality of the nasal septum (HP:0000419)1.83873191
104Abnormality of the phalanges of the hallux (HP:0010057)1.83781988
105Arterial tortuosity (HP:0005116)1.83597047
106Abnormality of the renal cortex (HP:0011035)1.83164354
107Aplasia cutis congenita (HP:0001057)1.83132103
108Small epiphyses (HP:0010585)1.81759425
109Adrenal hypoplasia (HP:0000835)1.81328966
110Decreased skull ossification (HP:0004331)1.81200861
111Hypolipoproteinemia (HP:0010981)1.80878347
112Hip contracture (HP:0003273)1.80280995
113Abnormal finger flexion creases (HP:0006143)1.79600725
114Tubular atrophy (HP:0000092)1.79422821
115Broad long bones (HP:0005622)1.78970636
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.77674043
117Osteolytic defects of the hand bones (HP:0009699)1.77674043
118Osteoarthritis (HP:0002758)1.76740310
119Thyroiditis (HP:0100646)1.76021303
120Flat cornea (HP:0007720)1.75721333
121Nephronophthisis (HP:0000090)1.75402161
122Abnormality of the acetabulum (HP:0003170)1.75213024
123Abnormality of the ischium (HP:0003174)1.75199188
124Natal tooth (HP:0000695)1.74907844
125Abnormality of the frontal sinuses (HP:0002687)1.74525866
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.74013186
127Overgrowth (HP:0001548)1.73572782
128Mesangial abnormality (HP:0001966)1.73471567
129Cerebral aneurysm (HP:0004944)1.73415200
130Absent phalangeal crease (HP:0006109)1.72859347
131Short 4th metacarpal (HP:0010044)1.71864034
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71864034
133Submucous cleft hard palate (HP:0000176)1.71783516
134Limited elbow extension (HP:0001377)1.70947779
135Asymmetry of the thorax (HP:0001555)1.69198809
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69131663
137Congenital sensorineural hearing impairment (HP:0008527)1.68619123
138Cranial hyperostosis (HP:0004437)1.68587517
139Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68570309
140Deviation of the hallux (HP:0010051)1.67706886
141Bowel diverticulosis (HP:0005222)1.67373172
142Spinal cord compression (HP:0002176)1.66977701
143Abnormality of the middle phalanges of the toes (HP:0010183)1.65984912
144Hypoplastic scapulae (HP:0000882)1.65789716
145Aplasia/Hypoplasia of the scapulae (HP:0006713)1.65789716
146Aplasia of the musculature (HP:0100854)1.62195371
147Disproportionate short-trunk short stature (HP:0003521)1.62056290
148Abnormality of the renal medulla (HP:0100957)1.58320489
149Patent foramen ovale (HP:0001655)1.57671634
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.57212452
151Abnormality of alanine metabolism (HP:0010916)1.56829481
152Hyperalaninemia (HP:0003348)1.56829481
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56829481
154Abnormality of the wing of the ilium (HP:0011867)1.56709611
155Choroideremia (HP:0001139)1.56694904
156Abnormal ventriculo-arterial connection (HP:0011563)1.56126614
157Transposition of the great arteries (HP:0001669)1.56126614
158Abnormal connection of the cardiac segments (HP:0011545)1.56126614
159Renal cortical cysts (HP:0000803)1.56069276
160Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.53864387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.45744347
2LATS13.88685161
3CASK3.09110318
4NUAK12.73802860
5EPHA32.57001114
6TRIM282.52948081
7ACVR1B2.47153328
8TAF12.30391916
9STK38L2.29447573
10CDK82.28634993
11SIK12.13313570
12EPHB22.12510022
13WNK32.03674334
14DMPK1.99642656
15STK241.98897201
16ZAK1.94908196
17INSRR1.93215114
18TRPM71.90724019
19PDK21.90706115
20EIF2AK21.88132268
21STK31.77137446
22MAP4K21.74897259
23PIK3CA1.72218446
24PDGFRA1.71857467
25PNCK1.64339302
26FRK1.58225695
27TTN1.48023139
28PLK21.46382374
29STK391.41839969
30PKN11.40167899
31VRK21.37984187
32EIF2AK31.37581003
33LATS21.35136891
34WNK41.35073340
35BMPR1B1.34048187
36MAP3K121.31246035
37PAK21.28113937
38MAPKAPK51.25585029
39MKNK21.22684600
40AKT31.20359565
41NEK91.20336935
42WEE11.20261981
43NEK61.19816822
44TGFBR21.19505028
45EPHB11.17434708
46MKNK11.16378676
47ERBB41.15997198
48TNIK1.15653223
49PLK31.10633326
50CAMK1D1.10005749
51MELK1.09050676
52MUSK1.08924519
53MET1.08699407
54MYLK1.08306726
55FER1.06659136
56ROCK21.05937532
57PRKD21.03294478
58FGFR21.03265468
59WNK11.01944231
60CAMK1G1.00936188
61CLK11.00099551
62MAP3K140.99995149
63PRKCE0.99566740
64PDGFRB0.98902419
65PINK10.97554579
66VRK10.97315220
67ROCK10.94640780
68CSNK1G20.91581176
69PRKD30.91081509
70IRAK30.89417715
71CDK120.89094497
72PAK30.88732291
73CSNK1G30.84729647
74TGFBR10.83416357
75ERBB30.82234016
76MAP3K20.77836733
77CDK90.77553498
78PIK3CG0.77292594
79BLK0.77223896
80CDK30.76256102
81IRAK10.76070600
82MAPK130.75203326
83BCR0.74433578
84MST40.74281876
85PBK0.73397481
86BRSK20.72733124
87CSNK1A1L0.69934460
88JAK10.69815592
89SIK30.69063288
90OXSR10.69055694
91OBSCN0.68881835
92EIF2AK10.67552072
93MAPKAPK30.66528827
94GSK3A0.66288597
95MARK20.65454918
96BMX0.65442454
97PTK20.64627715
98INSR0.63598991
99MAP3K40.60162776
100TLK10.57008063
101IKBKB0.56228796
102SGK20.56107236
103ADRBK10.56008651
104PRKCG0.54747744
105ADRBK20.53660016
106FGR0.53069632
107GRK10.52827300
108NLK0.52278959
109TNK20.49608914
110MAP2K10.49242174
111CHUK0.48924665
112TXK0.48900587
113TTK0.48429701
114PLK40.47693788
115STK160.47376294
116ATM0.46318300
117GRK70.46304623
118PTK2B0.45866934
119CSNK1G10.45762504
120YES10.45367291
121BMPR20.45314352
122FLT30.44187345
123MTOR0.43997255
124CDC42BPA0.43649332
125ILK0.43167101
126CHEK20.41845143
127PRKG10.41750769
128IRAK40.41716052
129PRKD10.41685281
130NEK10.41442398
131ABL10.41318404
132NTRK30.41166009
133FGFR30.40550506
134PRPF4B0.39887588
135CDK70.38322527
136MAPK110.37766075
137RPS6KA50.37666882
138CSNK1D0.37478453
139PRKCI0.36065999
140MAPKAPK20.35532111
141ATR0.35026854
142CAMK2D0.34409141
143CSNK1A10.33971338
144STK40.33905235
145DYRK20.33858703
146GRK50.33858703
147CAMK2A0.32654041
148FGFR10.32576417
149SRC0.31720203
150SIK20.31565133

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.25451780
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.57771956
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35372324
4Propanoate metabolism_Homo sapiens_hsa006402.27795462
5Homologous recombination_Homo sapiens_hsa034402.18804329
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06381463
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00926424
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00407606
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96815644
10Focal adhesion_Homo sapiens_hsa045101.93167478
11Basal cell carcinoma_Homo sapiens_hsa052171.92844639
12Protein digestion and absorption_Homo sapiens_hsa049741.89692228
13Nitrogen metabolism_Homo sapiens_hsa009101.85027776
14Malaria_Homo sapiens_hsa051441.83001827
15Melanoma_Homo sapiens_hsa052181.80655705
16Sulfur metabolism_Homo sapiens_hsa009201.74841443
17Selenocompound metabolism_Homo sapiens_hsa004501.73313844
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.65342917
19Axon guidance_Homo sapiens_hsa043601.65339304
20Hedgehog signaling pathway_Homo sapiens_hsa043401.59564577
21TGF-beta signaling pathway_Homo sapiens_hsa043501.58331304
22One carbon pool by folate_Homo sapiens_hsa006701.55927011
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49100957
24Wnt signaling pathway_Homo sapiens_hsa043101.46905805
25Prostate cancer_Homo sapiens_hsa052151.46335354
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41358496
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38766779
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37625654
29MicroRNAs in cancer_Homo sapiens_hsa052061.37396451
30Adherens junction_Homo sapiens_hsa045201.36063395
31Hippo signaling pathway_Homo sapiens_hsa043901.34514233
32Fat digestion and absorption_Homo sapiens_hsa049751.33542461
33Amoebiasis_Homo sapiens_hsa051461.33106008
34Proteoglycans in cancer_Homo sapiens_hsa052051.32908857
35Small cell lung cancer_Homo sapiens_hsa052221.31812232
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31287103
37Sphingolipid metabolism_Homo sapiens_hsa006001.28672279
38Basal transcription factors_Homo sapiens_hsa030221.27844977
39Circadian rhythm_Homo sapiens_hsa047101.27101834
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27048949
41Nucleotide excision repair_Homo sapiens_hsa034201.24758890
42Dilated cardiomyopathy_Homo sapiens_hsa054141.24633108
43Butanoate metabolism_Homo sapiens_hsa006501.20583686
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.20457732
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.20259361
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20232648
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20095211
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17068968
49Autoimmune thyroid disease_Homo sapiens_hsa053201.15844749
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13746741
51Glutathione metabolism_Homo sapiens_hsa004801.13549650
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13162700
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12687857
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10103742
55RNA polymerase_Homo sapiens_hsa030201.09504568
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09429221
57Linoleic acid metabolism_Homo sapiens_hsa005911.09128284
58Ether lipid metabolism_Homo sapiens_hsa005651.07900048
59Pathways in cancer_Homo sapiens_hsa052001.07714564
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07653835
61Vitamin digestion and absorption_Homo sapiens_hsa049771.07327737
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06388558
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04884616
64Ovarian steroidogenesis_Homo sapiens_hsa049131.04231845
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03164164
66Ras signaling pathway_Homo sapiens_hsa040141.03100791
67Arginine and proline metabolism_Homo sapiens_hsa003301.02552454
68Pancreatic cancer_Homo sapiens_hsa052121.01421199
69Complement and coagulation cascades_Homo sapiens_hsa046100.98482142
70RNA degradation_Homo sapiens_hsa030180.96838579
71Arachidonic acid metabolism_Homo sapiens_hsa005900.95415153
72Mismatch repair_Homo sapiens_hsa034300.94493634
73p53 signaling pathway_Homo sapiens_hsa041150.93824144
74Vitamin B6 metabolism_Homo sapiens_hsa007500.92734310
75Rheumatoid arthritis_Homo sapiens_hsa053230.91659135
76Rap1 signaling pathway_Homo sapiens_hsa040150.89527184
77Chemical carcinogenesis_Homo sapiens_hsa052040.89076860
78Caffeine metabolism_Homo sapiens_hsa002320.88342515
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.86719897
80Phagosome_Homo sapiens_hsa041450.84831480
81TNF signaling pathway_Homo sapiens_hsa046680.84639515
82Fatty acid elongation_Homo sapiens_hsa000620.82803445
83Tryptophan metabolism_Homo sapiens_hsa003800.81690821
84Chronic myeloid leukemia_Homo sapiens_hsa052200.81350082
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.80739175
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.80295074
87Steroid biosynthesis_Homo sapiens_hsa001000.78684070
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76873703
89Bladder cancer_Homo sapiens_hsa052190.76817456
90N-Glycan biosynthesis_Homo sapiens_hsa005100.75334794
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75223407
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.75077431
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74875990
94Melanogenesis_Homo sapiens_hsa049160.73413961
95Retinol metabolism_Homo sapiens_hsa008300.73369796
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71436989
97Glioma_Homo sapiens_hsa052140.71284061
98Fanconi anemia pathway_Homo sapiens_hsa034600.71059232
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.70400439
100Platelet activation_Homo sapiens_hsa046110.70170162
101Renin-angiotensin system_Homo sapiens_hsa046140.70021292
102Lysine degradation_Homo sapiens_hsa003100.69520308
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69115036
104Peroxisome_Homo sapiens_hsa041460.69096622
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68742359
106Pyruvate metabolism_Homo sapiens_hsa006200.68190508
107Tight junction_Homo sapiens_hsa045300.67992058
108Notch signaling pathway_Homo sapiens_hsa043300.64110689
109Dorso-ventral axis formation_Homo sapiens_hsa043200.62765306
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62433787
111HTLV-I infection_Homo sapiens_hsa051660.62300512
112MAPK signaling pathway_Homo sapiens_hsa040100.61906238
113Taste transduction_Homo sapiens_hsa047420.61170072
114Renal cell carcinoma_Homo sapiens_hsa052110.61117371
115Serotonergic synapse_Homo sapiens_hsa047260.60881208
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.60791575
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60789133
118Hematopoietic cell lineage_Homo sapiens_hsa046400.60732115
119ErbB signaling pathway_Homo sapiens_hsa040120.59831656
120Nicotine addiction_Homo sapiens_hsa050330.58551738
121cAMP signaling pathway_Homo sapiens_hsa040240.57942380
122Protein export_Homo sapiens_hsa030600.57312640
123Choline metabolism in cancer_Homo sapiens_hsa052310.56738877
124ABC transporters_Homo sapiens_hsa020100.56112022
125Phototransduction_Homo sapiens_hsa047440.55945027
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.55667487
127Osteoclast differentiation_Homo sapiens_hsa043800.55542036
128Viral myocarditis_Homo sapiens_hsa054160.55031116
129Toxoplasmosis_Homo sapiens_hsa051450.54512661
130Graft-versus-host disease_Homo sapiens_hsa053320.54146194
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53488197
132Hepatitis B_Homo sapiens_hsa051610.53354916
133Fatty acid degradation_Homo sapiens_hsa000710.52755195
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.52599401
135FoxO signaling pathway_Homo sapiens_hsa040680.52305769
136Proteasome_Homo sapiens_hsa030500.51056609
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.50634411
138Cocaine addiction_Homo sapiens_hsa050300.50111719
139Metabolic pathways_Homo sapiens_hsa011000.50098634
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49787763
141Oxidative phosphorylation_Homo sapiens_hsa001900.49753946
142beta-Alanine metabolism_Homo sapiens_hsa004100.49696705
143Glycerolipid metabolism_Homo sapiens_hsa005610.49279674
144Non-homologous end-joining_Homo sapiens_hsa034500.49129355
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48603995
146Mineral absorption_Homo sapiens_hsa049780.48457758
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47770923
148Asthma_Homo sapiens_hsa053100.47430307
149Purine metabolism_Homo sapiens_hsa002300.47016450
150* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45593772
151Colorectal cancer_Homo sapiens_hsa052100.45490385
152Salmonella infection_Homo sapiens_hsa051320.45457782
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44117145
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43495474
155Calcium signaling pathway_Homo sapiens_hsa040200.42894299
156Morphine addiction_Homo sapiens_hsa050320.42169527
157PPAR signaling pathway_Homo sapiens_hsa033200.41855297
158Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41646360

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