GYG1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of germinal center formation (GO:0002634)6.03141046
2regulation of memory T cell differentiation (GO:0043380)5.95468454
3negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.81424609
4negative regulation of DNA-templated transcription, elongation (GO:0032785)4.67710801
5regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.59441247
6intraciliary transport (GO:0042073)4.33362405
7positive regulation of defense response to virus by host (GO:0002230)4.23665344
8positive regulation of T-helper 1 type immune response (GO:0002827)4.22524936
9protein targeting to lysosome (GO:0006622)4.19678207
10establishment of protein localization to vacuole (GO:0072666)4.19678207
11protein targeting to vacuole (GO:0006623)4.19678207
12xenobiotic catabolic process (GO:0042178)4.17769236
13CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.15460261
14T-helper cell differentiation (GO:0042093)4.15460261
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.10172717
16regulation of activation of Janus kinase activity (GO:0010533)4.01994748
17preassembly of GPI anchor in ER membrane (GO:0016254)3.99949671
18estrogen biosynthetic process (GO:0006703)3.98130375
19T cell differentiation involved in immune response (GO:0002292)3.87646633
20alpha-beta T cell differentiation involved in immune response (GO:0002293)3.87646633
21alpha-beta T cell activation involved in immune response (GO:0002287)3.87646633
22organelle membrane fusion (GO:0090174)3.82260539
23protein-cofactor linkage (GO:0018065)3.77968838
24Peyers patch development (GO:0048541)3.77656261
25mucosal-associated lymphoid tissue development (GO:0048537)3.77656261
26mature B cell differentiation involved in immune response (GO:0002313)3.70447444
27regulation of glucokinase activity (GO:0033131)3.66562632
28regulation of hexokinase activity (GO:1903299)3.66562632
29protein K63-linked deubiquitination (GO:0070536)3.64768452
30magnesium ion transport (GO:0015693)3.61605560
31negative regulation of heart rate (GO:0010459)3.60297656
32multicellular organism reproduction (GO:0032504)3.57674715
33glycogen catabolic process (GO:0005980)3.49898728
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49322770
35response to interferon-beta (GO:0035456)3.49076682
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.44855866
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42237862
38cellular polysaccharide catabolic process (GO:0044247)3.41055274
39regulation of T cell mediated cytotoxicity (GO:0001914)3.38500424
40killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.26511265
41disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.26511265
42glucan catabolic process (GO:0009251)3.24199037
43negative regulation of cell killing (GO:0031342)3.23069512
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.23069512
45regulation of T-helper 1 type immune response (GO:0002825)3.22497942
46DNA deamination (GO:0045006)3.22272422
47histone H2A ubiquitination (GO:0033522)3.18888736
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14404601
49monoubiquitinated protein deubiquitination (GO:0035520)3.13338947
50dopamine transport (GO:0015872)3.12180297
51inositol phosphate dephosphorylation (GO:0046855)3.08790134
52phosphorylated carbohydrate dephosphorylation (GO:0046838)3.08790134
53mitochondrial DNA replication (GO:0006264)3.08042201
54polysaccharide catabolic process (GO:0000272)3.07654395
55regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.05284753
56positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.02793033
57respiratory chain complex IV assembly (GO:0008535)3.02363648
58negative regulation of bone resorption (GO:0045779)3.01286047
59positive regulation of interleukin-17 production (GO:0032740)2.99584922
60protein localization to lysosome (GO:0061462)2.97764392
61protein localization to vacuole (GO:0072665)2.97764392
62mannosylation (GO:0097502)2.97174446
63positive regulation of natural killer cell activation (GO:0032816)2.96352194
64glucosamine-containing compound catabolic process (GO:1901072)2.95696786
65neutrophil mediated immunity (GO:0002446)2.95318425
66positive regulation of interleukin-8 secretion (GO:2000484)2.94836923
67C-terminal protein lipidation (GO:0006501)2.93522849
68one-carbon compound transport (GO:0019755)2.91373552
69negative regulation of thymocyte apoptotic process (GO:0070244)2.90198785
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89910621
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89910621
72isotype switching (GO:0045190)2.89910621
73protein K11-linked deubiquitination (GO:0035871)2.85888326
74cellular response to interleukin-15 (GO:0071350)2.85278342
75inositol phosphate catabolic process (GO:0071545)2.83765615
76cellular response to gamma radiation (GO:0071480)2.83074074
77galactose catabolic process (GO:0019388)2.79787305
78regulation of interleukin-8 secretion (GO:2000482)2.79300189
79positive regulation of B cell proliferation (GO:0030890)2.79209698
80regulation of integrin activation (GO:0033623)2.78683154
81antigen processing and presentation via MHC class Ib (GO:0002475)2.77721684
82B cell activation involved in immune response (GO:0002312)2.77618938
83regulation of mitotic spindle checkpoint (GO:1903504)2.77467595
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77467595
85positive regulation of cell fate commitment (GO:0010455)2.76740021
86positive regulation of fibroblast migration (GO:0010763)2.74074550
87positive regulation of circadian rhythm (GO:0042753)2.73761266
88positive regulation of histone H3-K4 methylation (GO:0051571)2.71899177
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70726490
90cytochrome complex assembly (GO:0017004)2.69172320
91histone H2A monoubiquitination (GO:0035518)2.67820595
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65901985
93ribosomal large subunit biogenesis (GO:0042273)2.65229566
94mature B cell differentiation (GO:0002335)2.64546379
95galactose metabolic process (GO:0006012)2.60519598
96carnitine metabolic process (GO:0009437)2.60459770
97CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.59938245
98histone H2A acetylation (GO:0043968)2.59117041
99negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.56621413
100regulation of growth of symbiont in host (GO:0044126)2.56621413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61673509
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.13422008
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07984727
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.80455782
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64735591
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.51665524
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.45479298
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.39876871
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39237107
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32173109
11GATA1_22025678_ChIP-Seq_K562_Human2.30966802
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.28718342
13VDR_23849224_ChIP-Seq_CD4+_Human2.25529654
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.20801421
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.16700119
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13683190
17ELK1_19687146_ChIP-ChIP_HELA_Human2.12816814
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10888527
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08961819
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04248515
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03018159
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01817247
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99840198
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97686318
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95105360
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92823714
27VDR_22108803_ChIP-Seq_LS180_Human1.91332845
28SCL_19346495_ChIP-Seq_HPC-7_Human1.89702457
29IGF1R_20145208_ChIP-Seq_DFB_Human1.84716987
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.78924549
31FOXA1_21572438_ChIP-Seq_LNCaP_Human1.77676096
32ZNF274_21170338_ChIP-Seq_K562_Hela1.72413642
33MYB_26560356_Chip-Seq_TH2_Human1.71309899
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68906670
35IRF1_19129219_ChIP-ChIP_H3396_Human1.63890652
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63429299
37BCAT_22108803_ChIP-Seq_LS180_Human1.60222883
38HTT_18923047_ChIP-ChIP_STHdh_Human1.60109403
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54943327
40GATA3_26560356_Chip-Seq_TH2_Human1.54832782
41GATA3_27048872_Chip-Seq_THYMUS_Human1.54267331
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52709242
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52334460
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.50596010
45TP53_22573176_ChIP-Seq_HFKS_Human1.49531210
46PRDM14_20953172_ChIP-Seq_ESCs_Human1.46048719
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45895676
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.45895676
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43601993
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.41515818
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37526225
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.32112151
53AR_20517297_ChIP-Seq_VCAP_Human1.31217170
54ER_23166858_ChIP-Seq_MCF-7_Human1.28338931
55TAF15_26573619_Chip-Seq_HEK293_Human1.27226755
56SOX2_19829295_ChIP-Seq_ESCs_Human1.26526570
57NANOG_19829295_ChIP-Seq_ESCs_Human1.26526570
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26487150
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26183983
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25771015
61FOXP3_21729870_ChIP-Seq_TREG_Human1.24890064
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23794971
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.23676846
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23243269
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22746285
66SPI1_23547873_ChIP-Seq_NB4_Human1.22441929
67P300_19829295_ChIP-Seq_ESCs_Human1.22176520
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20994057
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20693944
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20122953
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19361756
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18862758
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18474899
74CDX2_22108803_ChIP-Seq_LS180_Human1.17540734
75SMRT_27268052_Chip-Seq_Bcells_Human1.15563124
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15558815
77MYC_18940864_ChIP-ChIP_HL60_Human1.14166713
78JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14161197
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.14146399
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12314457
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.11086671
82VDR_24787735_ChIP-Seq_THP-1_Human1.10886903
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10739176
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.09643573
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.09492554
86ERG_20517297_ChIP-Seq_VCAP_Human1.07543790
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.06486014
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05852648
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05286618
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05209091
91P53_22387025_ChIP-Seq_ESCs_Mouse1.04932701
92EWS_26573619_Chip-Seq_HEK293_Human1.04932340
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.04495050
94TCF4_22108803_ChIP-Seq_LS180_Human1.04088640
95STAT1_20625510_ChIP-Seq_HELA_Human1.02341158
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01111529
97AR_25329375_ChIP-Seq_VCAP_Human1.01025549
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00921582
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00163595
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.98987763

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.26422999
2MP0003011_delayed_dark_adaptation4.29262855
3MP0002166_altered_tumor_susceptibility3.69869718
4MP0003763_abnormal_thymus_physiology3.47921172
5MP0002006_tumorigenesis3.06987264
6MP0001835_abnormal_antigen_presentation2.67970906
7MP0005671_abnormal_response_to2.62676683
8MP0002009_preneoplasia2.51528917
9MP0005670_abnormal_white_adipose2.29211429
10MP0010386_abnormal_urinary_bladder2.27854669
11MP0005645_abnormal_hypothalamus_physiol2.19863646
12MP0001986_abnormal_taste_sensitivity2.05525098
13MP0009785_altered_susceptibility_to2.03438923
14MP0005084_abnormal_gallbladder_morpholo1.88125265
15MP0008872_abnormal_physiological_respon1.82587005
16MP0005075_abnormal_melanosome_morpholog1.74229016
17MP0003252_abnormal_bile_duct1.69920427
18MP0001984_abnormal_olfaction1.69101705
19MP0005379_endocrine/exocrine_gland_phen1.64610595
20MP0003724_increased_susceptibility_to1.64211180
21MP0000003_abnormal_adipose_tissue1.61516331
22MP0003283_abnormal_digestive_organ1.60531184
23MP0002876_abnormal_thyroid_physiology1.60038415
24MP0003172_abnormal_lysosome_physiology1.59968156
25MP0005167_abnormal_blood-brain_barrier1.55367218
26MP0008875_abnormal_xenobiotic_pharmacok1.54013410
27MP0001800_abnormal_humoral_immune1.53935086
28MP0000383_abnormal_hair_follicle1.49768299
29MP0006072_abnormal_retinal_apoptosis1.43517466
30MP0005464_abnormal_platelet_physiology1.42230247
31MP0005000_abnormal_immune_tolerance1.41888045
32MP0005058_abnormal_lysosome_morphology1.40024668
33MP0002277_abnormal_respiratory_mucosa1.39103386
34MP0003806_abnormal_nucleotide_metabolis1.38622904
35MP0003195_calcinosis1.38271928
36MP0002148_abnormal_hypersensitivity_rea1.37756239
37MP0002723_abnormal_immune_serum1.37331139
38MP0003183_abnormal_peptide_metabolism1.35396374
39MP0001765_abnormal_ion_homeostasis1.34540317
40MP0002420_abnormal_adaptive_immunity1.31304805
41MP0001819_abnormal_immune_cell1.30007994
42MP0005410_abnormal_fertilization1.27101121
43MP0000516_abnormal_urinary_system1.27080994
44MP0005367_renal/urinary_system_phenotyp1.27080994
45MP0001664_abnormal_digestion1.26834069
46MP0001919_abnormal_reproductive_system1.25201899
47MP0002928_abnormal_bile_duct1.24129609
48MP0002452_abnormal_antigen_presenting1.18627595
49MP0009764_decreased_sensitivity_to1.18432764
50MP0002102_abnormal_ear_morphology1.16539787
51MP0002398_abnormal_bone_marrow1.15878782
52MP0003436_decreased_susceptibility_to1.15589305
53MP0000427_abnormal_hair_cycle1.14725552
54MP0005253_abnormal_eye_physiology1.13404818
55MP0002163_abnormal_gland_morphology1.11634125
56MP0001790_abnormal_immune_system1.11400449
57MP0005387_immune_system_phenotype1.11400449
58MP0003786_premature_aging1.08185003
59MP0002837_dystrophic_cardiac_calcinosis1.07177455
60MP0000681_abnormal_thyroid_gland1.04524257
61MP0005389_reproductive_system_phenotype1.03980864
62MP0001853_heart_inflammation1.03727527
63MP0010678_abnormal_skin_adnexa1.03724544
64MP0001440_abnormal_grooming_behavior1.02950653
65MP0000716_abnormal_immune_system1.02057247
66MP0010155_abnormal_intestine_physiology1.02049991
67MP0000689_abnormal_spleen_morphology1.01439491
68MP0010307_abnormal_tumor_latency0.99786892
69MP0004215_abnormal_myocardial_fiber0.96126638
70MP0004043_abnormal_pH_regulation0.92098125
71MP0002998_abnormal_bone_remodeling0.91659843
72MP0005025_abnormal_response_to0.90032069
73MP0000538_abnormal_urinary_bladder0.89692756
74MP0001501_abnormal_sleep_pattern0.89351865
75MP0003646_muscle_fatigue0.87186366
76MP0005332_abnormal_amino_acid0.86911391
77MP0001529_abnormal_vocalization0.86783912
78MP0005375_adipose_tissue_phenotype0.86750067
79MP0003943_abnormal_hepatobiliary_system0.86179377
80MP0008469_abnormal_protein_level0.84561724
81MP0005220_abnormal_exocrine_pancreas0.84453175
82MP0003638_abnormal_response/metabolism_0.84086486
83MP0001968_abnormal_touch/_nociception0.83421242
84MP0002429_abnormal_blood_cell0.83416416
85MP0009697_abnormal_copulation0.83055097
86MP0002419_abnormal_innate_immunity0.82876888
87MP0002405_respiratory_system_inflammati0.81862918
88MP0001177_atelectasis0.81839000
89MP0005174_abnormal_tail_pigmentation0.80983984
90MP0005165_increased_susceptibility_to0.80816448
91MP0002909_abnormal_adrenal_gland0.80732462
92MP0004142_abnormal_muscle_tone0.80246076
93MP0000465_gastrointestinal_hemorrhage0.78322721
94MP0002722_abnormal_immune_system0.76226721
95MP0001879_abnormal_lymphatic_vessel0.76132207
96MP0001845_abnormal_inflammatory_respons0.74259222
97MP0001502_abnormal_circadian_rhythm0.73627681
98MP0000569_abnormal_digit_pigmentation0.71506700
99MP0004134_abnormal_chest_morphology0.70711591
100MP0003866_abnormal_defecation0.69510845

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.81483164
2Panhypogammaglobulinemia (HP:0003139)4.19625737
3Abnormality of T cell number (HP:0011839)4.11282385
4Inflammation of the large intestine (HP:0002037)3.96107311
5Large for gestational age (HP:0001520)3.89825845
6Chronic mucocutaneous candidiasis (HP:0002728)3.64576184
7Recurrent cutaneous fungal infections (HP:0011370)3.64576184
8Abnormality of T cells (HP:0002843)3.59965166
9Colitis (HP:0002583)3.59036626
10Gastrointestinal inflammation (HP:0004386)3.53869653
11Dicarboxylic aciduria (HP:0003215)3.48691021
12Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48691021
13Optic neuritis (HP:0100653)3.45979161
14Retrobulbar optic neuritis (HP:0100654)3.45979161
15Hypoglycemic coma (HP:0001325)3.44978286
16Encephalitis (HP:0002383)3.39367454
17Abnormality of T cell physiology (HP:0011840)3.39282314
18IgG deficiency (HP:0004315)3.27352895
19Metabolic alkalosis (HP:0200114)3.25739041
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.25363137
21Abnormality of the prostate (HP:0008775)3.14123812
22Thyroiditis (HP:0100646)3.12372228
23Hypothermia (HP:0002045)3.07043344
24Hypokalemic alkalosis (HP:0001949)3.05307996
25Myositis (HP:0100614)3.02706876
26Hepatic necrosis (HP:0002605)3.00024553
27Orchitis (HP:0100796)2.92325463
28Vacuolated lymphocytes (HP:0001922)2.91374303
29Congenital stationary night blindness (HP:0007642)2.91285579
30Agammaglobulinemia (HP:0004432)2.90828760
31Fatigue (HP:0012378)2.74018503
32Methylmalonic acidemia (HP:0002912)2.70688783
33Abolished electroretinogram (ERG) (HP:0000550)2.69920535
34Hypoglycemic seizures (HP:0002173)2.67092961
35Recurrent viral infections (HP:0004429)2.66149868
36Severe combined immunodeficiency (HP:0004430)2.65714996
373-Methylglutaconic aciduria (HP:0003535)2.61235320
38Bundle branch block (HP:0011710)2.54830086
39Dyschromatopsia (HP:0007641)2.52714931
40Stomatitis (HP:0010280)2.52517665
41Sensory axonal neuropathy (HP:0003390)2.51386625
42Duplicated collecting system (HP:0000081)2.51050039
43Menstrual irregularities (HP:0000858)2.48981144
44Prostate neoplasm (HP:0100787)2.45792121
45Abnormal rod and cone electroretinograms (HP:0008323)2.37823320
46Generalized aminoaciduria (HP:0002909)2.34589841
47Keratoconjunctivitis sicca (HP:0001097)2.33390531
48Abnormality of the renal collecting system (HP:0004742)2.28214752
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28053640
50Neuroendocrine neoplasm (HP:0100634)2.27639038
51Metaphyseal dysplasia (HP:0100255)2.24538701
52Keratoconjunctivitis (HP:0001096)2.18830463
53Hyperinsulinemic hypoglycemia (HP:0000825)2.18304119
54Ketosis (HP:0001946)2.18211465
55Viral hepatitis (HP:0006562)2.17606507
56Methylmalonic aciduria (HP:0012120)2.17235739
57Facial diplegia (HP:0001349)2.15933389
58Pheochromocytoma (HP:0002666)2.11492431
59Hepatocellular necrosis (HP:0001404)2.10462668
60Combined immunodeficiency (HP:0005387)2.05093958
61Retinal dysplasia (HP:0007973)2.03945757
62Ketoacidosis (HP:0001993)2.03931638
63Irregular vertebral endplates (HP:0003301)2.03017991
64Pulmonary fibrosis (HP:0002206)2.01749942
65Meningitis (HP:0001287)2.01543898
66Rectovaginal fistula (HP:0000143)1.99490531
67Rectal fistula (HP:0100590)1.99490531
68Stomach cancer (HP:0012126)1.97351330
69Abnormality of male internal genitalia (HP:0000022)1.96977926
70Alkalosis (HP:0001948)1.96917326
71Abnormality of eosinophils (HP:0001879)1.96835440
72Micronodular cirrhosis (HP:0001413)1.96260776
73Febrile seizures (HP:0002373)1.96155235
74Conjunctival hamartoma (HP:0100780)1.93770366
75Hypoproteinemia (HP:0003075)1.93427617
76Infertility (HP:0000789)1.93089374
77B lymphocytopenia (HP:0010976)1.91734439
78Pulmonary embolism (HP:0002204)1.90898746
79Molar tooth sign on MRI (HP:0002419)1.89539834
80Abnormality of midbrain morphology (HP:0002418)1.89539834
81Chronic diarrhea (HP:0002028)1.89054838
82Pancreatitis (HP:0001733)1.88667195
83Erythroderma (HP:0001019)1.88420799
84Prominent metopic ridge (HP:0005487)1.87642963
85Testicular atrophy (HP:0000029)1.85868566
86Albinism (HP:0001022)1.84719855
87Abnormality of B cell number (HP:0010975)1.83942715
88Progressive macrocephaly (HP:0004481)1.83473848
89Abnormality of the pleura (HP:0002103)1.83313749
90Tetany (HP:0001281)1.82535737
91Resting tremor (HP:0002322)1.80940211
92Elevated erythrocyte sedimentation rate (HP:0003565)1.79985627
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78492839
94Mitochondrial inheritance (HP:0001427)1.77876700
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77251477
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77251477
97Premature ovarian failure (HP:0008209)1.76602493
98Abnormality of macular pigmentation (HP:0008002)1.75290986
99Azoospermia (HP:0000027)1.73476468
100Abnormality of small intestinal villus morphology (HP:0011472)1.73257159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.71334995
2FRK3.69928567
3TXK3.66933285
4MAP4K23.64754579
5TAOK33.33478003
6CSF1R2.78587422
7PRKG22.74674130
8CLK12.71571749
9NUAK12.43417026
10MAP3K122.29861262
11SCYL22.28993357
12NEK12.25874471
13PHKG22.25085171
14PHKG12.25085171
15IKBKE1.91471544
16GRK11.78137820
17TRPM71.75510505
18LMTK21.75312339
19IKBKB1.72869973
20MAPK111.70438233
21BCKDK1.68525779
22CDC71.68447013
23ADRBK21.59468280
24MST41.59274099
25MAP3K141.51323915
26ZAK1.45743181
27WNK31.36669629
28TLK11.34962332
29TBK11.30227827
30EIF2AK21.23867460
31PLK41.20547933
32KIT1.20299108
33OXSR11.18024019
34JAK11.15772548
35BMPR1B1.15749553
36MAP4K11.13370347
37CHUK1.11370174
38STK391.09993060
39PINK11.08820486
40GRK61.08505234
41MAPK71.06527411
42STK38L1.05298321
43MAPK131.02211060
44SYK0.99149158
45TYK20.92155989
46MAP2K60.89567893
47ADRBK10.86826027
48ITK0.82817914
49PIK3CA0.81130311
50MAP2K30.80275576
51STK240.79942507
52FGFR20.74174160
53MYLK0.69158884
54PRKCQ0.68501239
55TEC0.66657192
56CCNB10.66403825
57CDK80.65030213
58IGF1R0.63859363
59LIMK10.63831598
60MAPK40.61600069
61MAP3K50.60552055
62WNK40.59713080
63MAP3K60.57584788
64PRKCE0.57014598
65ZAP700.55883627
66MAP2K20.53328558
67LCK0.51980195
68FGFR30.51581925
69ILK0.49348352
70IRAK40.49078169
71NME20.47660758
72INSRR0.46327930
73ABL10.44860945
74JAK30.43820237
75CSNK1G30.43680659
76ATM0.43498377
77ABL20.43004996
78LYN0.42677818
79CSNK1A1L0.42674323
80ERBB30.41885128
81FYN0.38762612
82HCK0.37288205
83TGFBR10.37116088
84PIM20.36911534
85TESK10.35688674
86GRK50.35275902
87PLK30.32556467
88MAPKAPK50.31482196
89BLK0.30451644
90BMPR20.29847152
91TESK20.29639575
92MAP2K40.29580434
93FES0.29369463
94ROCK10.29011722
95STK110.28514517
96STK160.28372545
97CSNK1D0.28167032
98EGFR0.27737374
99KDR0.27535844
100PIK3CG0.27059303

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.60809969
2Asthma_Homo sapiens_hsa053103.42290198
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.25849666
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.01721689
5Proteasome_Homo sapiens_hsa030502.90094172
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.87247817
7Primary immunodeficiency_Homo sapiens_hsa053402.44043667
8Antigen processing and presentation_Homo sapiens_hsa046122.41400027
9Graft-versus-host disease_Homo sapiens_hsa053322.34844840
10Allograft rejection_Homo sapiens_hsa053302.24246721
11Type I diabetes mellitus_Homo sapiens_hsa049402.20584953
12Rheumatoid arthritis_Homo sapiens_hsa053232.19043740
13Nitrogen metabolism_Homo sapiens_hsa009102.10884473
14Autoimmune thyroid disease_Homo sapiens_hsa053202.10810739
15Protein export_Homo sapiens_hsa030601.99228064
16Fatty acid elongation_Homo sapiens_hsa000621.88890868
17Butanoate metabolism_Homo sapiens_hsa006501.87175101
18Oxidative phosphorylation_Homo sapiens_hsa001901.77503100
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76153292
20Phototransduction_Homo sapiens_hsa047441.75029680
21Mismatch repair_Homo sapiens_hsa034301.68817114
22Homologous recombination_Homo sapiens_hsa034401.68072190
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67490384
24Olfactory transduction_Homo sapiens_hsa047401.65617499
25Circadian rhythm_Homo sapiens_hsa047101.63556504
26Basal transcription factors_Homo sapiens_hsa030221.61131584
27Renin-angiotensin system_Homo sapiens_hsa046141.54279496
28Leishmaniasis_Homo sapiens_hsa051401.48605630
29Salivary secretion_Homo sapiens_hsa049701.47047051
30Tryptophan metabolism_Homo sapiens_hsa003801.40927226
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34651901
32Caffeine metabolism_Homo sapiens_hsa002321.29899324
33One carbon pool by folate_Homo sapiens_hsa006701.26406034
34RNA degradation_Homo sapiens_hsa030181.25388244
35Fatty acid degradation_Homo sapiens_hsa000711.25365406
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23588359
37Propanoate metabolism_Homo sapiens_hsa006401.11899531
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.06824394
39Nucleotide excision repair_Homo sapiens_hsa034201.05261716
40Renin secretion_Homo sapiens_hsa049241.01611313
41Collecting duct acid secretion_Homo sapiens_hsa049661.00454724
42Staphylococcus aureus infection_Homo sapiens_hsa051500.97792164
43Fatty acid metabolism_Homo sapiens_hsa012120.97390643
44Regulation of autophagy_Homo sapiens_hsa041400.94684295
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93726910
46Other glycan degradation_Homo sapiens_hsa005110.90008140
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87730605
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.85569961
49Glutathione metabolism_Homo sapiens_hsa004800.83083280
50Tuberculosis_Homo sapiens_hsa051520.82584605
51Retinol metabolism_Homo sapiens_hsa008300.82243745
52Lysosome_Homo sapiens_hsa041420.82063512
53Purine metabolism_Homo sapiens_hsa002300.78439582
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78386001
55Parkinsons disease_Homo sapiens_hsa050120.78260191
56Chemical carcinogenesis_Homo sapiens_hsa052040.76432516
57Vibrio cholerae infection_Homo sapiens_hsa051100.75475540
58Epstein-Barr virus infection_Homo sapiens_hsa051690.74134843
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71492760
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68005145
61Peroxisome_Homo sapiens_hsa041460.65933833
62Platelet activation_Homo sapiens_hsa046110.64729441
63Hematopoietic cell lineage_Homo sapiens_hsa046400.64360538
64Fanconi anemia pathway_Homo sapiens_hsa034600.64024315
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62074664
66Viral myocarditis_Homo sapiens_hsa054160.58609634
67Herpes simplex infection_Homo sapiens_hsa051680.57981145
68Base excision repair_Homo sapiens_hsa034100.57746887
69Toxoplasmosis_Homo sapiens_hsa051450.55239731
70Legionellosis_Homo sapiens_hsa051340.54215586
71Ribosome_Homo sapiens_hsa030100.53649201
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.53522347
73Alzheimers disease_Homo sapiens_hsa050100.49514999
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48128625
75Inositol phosphate metabolism_Homo sapiens_hsa005620.47119982
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45287979
77beta-Alanine metabolism_Homo sapiens_hsa004100.45221248
78Insulin secretion_Homo sapiens_hsa049110.44732305
79Phagosome_Homo sapiens_hsa041450.43224443
80Circadian entrainment_Homo sapiens_hsa047130.42972999
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39734393
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38927478
83Linoleic acid metabolism_Homo sapiens_hsa005910.38154170
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35992299
85Cardiac muscle contraction_Homo sapiens_hsa042600.33750611
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33602102
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33008828
88Starch and sucrose metabolism_Homo sapiens_hsa005000.32546205
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32185631
90Arachidonic acid metabolism_Homo sapiens_hsa005900.30959702
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30606126
92Sulfur metabolism_Homo sapiens_hsa009200.30261164
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29477888
94Taste transduction_Homo sapiens_hsa047420.26584630
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26486330
96Pancreatic secretion_Homo sapiens_hsa049720.25929608
97Huntingtons disease_Homo sapiens_hsa050160.25591467
98N-Glycan biosynthesis_Homo sapiens_hsa005100.23763750
99Synaptic vesicle cycle_Homo sapiens_hsa047210.23397334
100Measles_Homo sapiens_hsa051620.23211446

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