ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.56382852
2	DNA deamination (GO:0045006)	6.28595404
3	Arp2/3 complex-mediated actin nucleation (GO:0034314)	5.59487006
4	cytidine metabolic process (GO:0046087)	5.41674194
5	cytidine catabolic process (GO:0006216)	5.41674194
6	cytidine deamination (GO:0009972)	5.41674194
7	actin nucleation (GO:0045010)	5.30659028
8	mature B cell differentiation involved in immune response (GO:0002313)	5.26435879
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.64947722
10	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.27505193
11	proteasome assembly (GO:0043248)	4.17004149
12	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.97547771
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.97202576
14	mature B cell differentiation (GO:0002335)	3.92910543
15	regulation of activation of Janus kinase activity (GO:0010533)	3.90276149
16	cytochrome complex assembly (GO:0017004)	3.77579940
17	protein neddylation (GO:0045116)	3.75190032
18	respiratory chain complex IV assembly (GO:0008535)	3.69127656
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.66614368
20	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.66614368
21	regulation of germinal center formation (GO:0002634)	3.64446845
22	platelet dense granule organization (GO:0060155)	3.62199695
23	response to interferon-beta (GO:0035456)	3.58648149
24	anterograde synaptic vesicle transport (GO:0048490)	3.48829232
25	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.47216266
26	mast cell activation (GO:0045576)	3.44842034
27	positive regulation of interleukin-8 secretion (GO:2000484)	3.44117995
28	prenylation (GO:0097354)	3.42628957
29	protein prenylation (GO:0018342)	3.42628957
30	negative regulation of thymocyte apoptotic process (GO:0070244)	3.41611400
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.31784824
32	ATP synthesis coupled proton transport (GO:0015986)	3.31784824
33	cellular response to interleukin-15 (GO:0071350)	3.28571690
34	immunoglobulin mediated immune response (GO:0016064)	3.27501735
35	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.24417488
36	regulation of cellular amino acid metabolic process (GO:0006521)	3.20949448
37	regulation of T cell mediated cytotoxicity (GO:0001914)	3.13676260
38	positive regulation of defense response to virus by host (GO:0002230)	3.10935815
39	respiratory electron transport chain (GO:0022904)	3.09737579
40	electron transport chain (GO:0022900)	3.07260172
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.03357406
42	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.02582892
43	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.02164266
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02011727
45	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.97933935
46	B cell mediated immunity (GO:0019724)	2.97390540
47	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.93043237
48	cellular ketone body metabolic process (GO:0046950)	2.90114364
49	negative regulation of T cell apoptotic process (GO:0070233)	2.89039539
50	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.86619896
51	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85126004
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85045787
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85045787
54	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85045787
55	glycogen catabolic process (GO:0005980)	2.84665208
56	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.83587997
57	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.83587997
58	regulation of interleukin-8 secretion (GO:2000482)	2.82526454
59	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.81953820
60	regulation of memory T cell differentiation (GO:0043380)	2.80836407
61	T cell costimulation (GO:0031295)	2.76422166
62	protein complex biogenesis (GO:0070271)	2.75180355
63	T cell receptor signaling pathway (GO:0050852)	2.74976753
64	organelle membrane fusion (GO:0090174)	2.73031402
65	lymphocyte costimulation (GO:0031294)	2.72892397
66	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.72482295
67	mast cell degranulation (GO:0043303)	2.72438592
68	mast cell activation involved in immune response (GO:0002279)	2.72438592
69	negative regulation of viral genome replication (GO:0045071)	2.72227602
70	signal peptide processing (GO:0006465)	2.71026934
71	positive regulation of T-helper 1 type immune response (GO:0002827)	2.70789388
72	regulation of gamma-delta T cell differentiation (GO:0045586)	2.70180165
73	ketone body metabolic process (GO:1902224)	2.69337370
74	positive regulation of histone H3-K4 methylation (GO:0051571)	2.69003267
75	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.68669035
76	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.67342846
77	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.67342846
78	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.67287631
79	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.65522856
80	interferon-gamma-mediated signaling pathway (GO:0060333)	2.65497364
81	negative regulation of ligase activity (GO:0051352)	2.65042296
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.65042296
83	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64549344
84	cellular response to interferon-beta (GO:0035458)	2.63798704
85	glucan catabolic process (GO:0009251)	2.63376064
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60752769
87	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.60737218
88	negative regulation of heart rate (GO:0010459)	2.60696271
89	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.60685513
90	response to interleukin-15 (GO:0070672)	2.60272357
91	mannosylation (GO:0097502)	2.59849695
92	cellular polysaccharide catabolic process (GO:0044247)	2.58828469
93	magnesium ion transport (GO:0015693)	2.58570255
94	one-carbon compound transport (GO:0019755)	2.57322391
95	positive regulation of lamellipodium assembly (GO:0010592)	2.55475389
96	pyrimidine nucleoside catabolic process (GO:0046135)	2.54838854
97	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.52732349
98	Peyers patch development (GO:0048541)	2.51893597
99	mucosal-associated lymphoid tissue development (GO:0048537)	2.51893597
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50738131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.83153145
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.34531226
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.82281155
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.58552400
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.38645133
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.26355191
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10029675
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.77344356
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.65091157
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.64821966
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64809422
12	VDR_22108803_ChIP-Seq_LS180_Human	2.61469199
13	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.51490171
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47701942
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45723196
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.39889728
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.32948008
18	GATA1_22025678_ChIP-Seq_K562_Human	2.23561804
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21760806
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.18063154
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13192494
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.11685781
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.04628006
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98293449
25	MYB_26560356_Chip-Seq_TH2_Human	1.96592179
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89933353
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.80168508
28	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.78171288
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.74681836
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72777733
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.70512066
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69211219
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68280991
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68153072
35	GATA3_26560356_Chip-Seq_TH2_Human	1.63992299
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58656763
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54376840
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51415857
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50509979
40	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.50108243
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.50062631
42	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.47601900
43	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.42602891
44	SPI1_23547873_ChIP-Seq_NB4_Human	1.41445582
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41309255
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.37228231
47	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35807603
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34718575
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34718575
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33396012
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33297392
52	NCOR_22424771_ChIP-Seq_293T_Human	1.29892638
53	GATA3_27048872_Chip-Seq_THYMUS_Human	1.28024465
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27923983
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27923983
56	AR_20517297_ChIP-Seq_VCAP_Human	1.25647827
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25560972
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23778240
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22249437
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21610851
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.20237343
62	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.16906322
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14923005
64	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.14554871
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14454920
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.13425862
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.10645761
68	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10277389
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09818167
70	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.09371216
71	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.08846080
72	E2F7_22180533_ChIP-Seq_HELA_Human	1.06777417
73	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06043311
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05034584
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04937820
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02880608
77	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02064746
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01918458
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01789784
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.01504693
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.98667656
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98427091
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97292736
84	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.96710492
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95859772
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.95063671
87	MYB_26560356_Chip-Seq_TH1_Human	0.94788800
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.93839084
89	TCF4_22108803_ChIP-Seq_LS180_Human	0.92891152
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.92840416
91	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.91835199
92	GBX2_23144817_ChIP-Seq_PC3_Human	0.91600590
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.91066054
94	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.90390027
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89920851
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.88594144
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.87622920
98	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.87354706
99	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.87019594
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84528911

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002166_altered_tumor_susceptibility	4.25654364
2	MP0005671_abnormal_response_to	3.71319254
3	MP0001835_abnormal_antigen_presentation	3.53323216
4	MP0000013_abnormal_adipose_tissue	3.43589490
5	MP0002006_tumorigenesis	3.40557559
6	MP0003806_abnormal_nucleotide_metabolis	3.36510264
7	MP0003011_delayed_dark_adaptation	3.04401788
8	MP0003763_abnormal_thymus_physiology	2.85333901
9	MP0009785_altered_susceptibility_to	2.73560594
10	MP0003195_calcinosis	2.56243580
11	MP0005645_abnormal_hypothalamus_physiol	2.40487252
12	MP0002009_preneoplasia	2.13739761
13	MP0000569_abnormal_digit_pigmentation	2.03526275
14	MP0003786_premature_aging	2.02369392
15	MP0005075_abnormal_melanosome_morpholog	1.99791486
16	MP0001800_abnormal_humoral_immune	1.96535870
17	MP0001986_abnormal_taste_sensitivity	1.90428114
18	MP0005174_abnormal_tail_pigmentation	1.85656949
19	MP0002723_abnormal_immune_serum	1.78153896
20	MP0002148_abnormal_hypersensitivity_rea	1.76455998
21	MP0002822_catalepsy	1.76232142
22	MP0005670_abnormal_white_adipose	1.74198572
23	MP0002102_abnormal_ear_morphology	1.72399517
24	MP0005000_abnormal_immune_tolerance	1.71518704
25	MP0001853_heart_inflammation	1.71315219
26	MP0006054_spinal_hemorrhage	1.68437543
27	MP0002420_abnormal_adaptive_immunity	1.63253355
28	MP0001819_abnormal_immune_cell	1.63242446
29	MP0001790_abnormal_immune_system	1.62016328
30	MP0005387_immune_system_phenotype	1.62016328
31	MP0002452_abnormal_antigen_presenting	1.61990109
32	MP0002837_dystrophic_cardiac_calcinosis	1.51856740
33	MP0003866_abnormal_defecation	1.44036387
34	MP0000015_abnormal_ear_pigmentation	1.34487302
35	MP0005025_abnormal_response_to	1.34340776
36	MP0008872_abnormal_physiological_respon	1.33759337
37	MP0010155_abnormal_intestine_physiology	1.33630417
38	MP0006036_abnormal_mitochondrial_physio	1.33576198
39	MP0000685_abnormal_immune_system	1.32378995
40	MP0002638_abnormal_pupillary_reflex	1.31631142
41	MP0004147_increased_porphyrin_level	1.31372520
42	MP0003436_decreased_susceptibility_to	1.30235177
43	MP0002398_abnormal_bone_marrow	1.28191636
44	MP0002277_abnormal_respiratory_mucosa	1.27800759
45	MP0004043_abnormal_pH_regulation	1.27778235
46	MP0009764_decreased_sensitivity_to	1.26815757
47	MP0008877_abnormal_DNA_methylation	1.23686015
48	MP0000427_abnormal_hair_cycle	1.20040756
49	MP0002095_abnormal_skin_pigmentation	1.19120637
50	MP0004142_abnormal_muscle_tone	1.18899287
51	MP0003646_muscle_fatigue	1.17088910
52	MP0000716_abnormal_immune_system	1.16755280
53	MP0005379_endocrine/exocrine_gland_phen	1.14266324
54	MP0005367_renal/urinary_system_phenotyp	1.13342137
55	MP0000516_abnormal_urinary_system	1.13342137
56	MP0002405_respiratory_system_inflammati	1.09670841
57	MP0000689_abnormal_spleen_morphology	1.06883904
58	MP0004145_abnormal_muscle_electrophysio	1.06739782
59	MP0002876_abnormal_thyroid_physiology	1.06717523
60	MP0009333_abnormal_splenocyte_physiolog	1.04003354
61	MP0003950_abnormal_plasma_membrane	1.02918335
62	MP0006072_abnormal_retinal_apoptosis	1.02733618
63	MP0005464_abnormal_platelet_physiology	1.02604880
64	MP0003638_abnormal_response/metabolism_	1.01048419
65	MP0001845_abnormal_inflammatory_respons	0.99230211
66	MP0005084_abnormal_gallbladder_morpholo	0.98318936
67	MP0001968_abnormal_touch/_nociception	0.97684279
68	MP0008007_abnormal_cellular_replicative	0.96297380
69	MP0002909_abnormal_adrenal_gland	0.95631710
70	MP0003283_abnormal_digestive_organ	0.95307504
71	MP0002163_abnormal_gland_morphology	0.95269309
72	MP0002429_abnormal_blood_cell	0.94246148
73	MP0005389_reproductive_system_phenotype	0.93365237
74	MP0005551_abnormal_eye_electrophysiolog	0.91278050
75	MP0010386_abnormal_urinary_bladder	0.90448446
76	MP0001919_abnormal_reproductive_system	0.89939390
77	MP0001873_stomach_inflammation	0.89589223
78	MP0008469_abnormal_protein_level	0.87195090
79	MP0002722_abnormal_immune_system	0.87025400
80	MP0001984_abnormal_olfaction	0.84502759
81	MP0002419_abnormal_innate_immunity	0.84283774
82	MP0010094_abnormal_chromosome_stability	0.83456042
83	MP0003137_abnormal_impulse_conducting	0.82962621
84	MP0001765_abnormal_ion_homeostasis	0.82445665
85	MP0003186_abnormal_redox_activity	0.82345597
86	MP0005253_abnormal_eye_physiology	0.81854461
87	MP0005410_abnormal_fertilization	0.80589913
88	MP0000371_diluted_coat_color	0.76394138
89	MP0004885_abnormal_endolymph	0.75909423
90	MP0000372_irregular_coat_pigmentation	0.73572693
91	MP0009745_abnormal_behavioral_response	0.73463243
92	MP0000003_abnormal_adipose_tissue	0.72438242
93	MP0000647_abnormal_sebaceous_gland	0.71510832
94	MP0002693_abnormal_pancreas_physiology	0.71043021
95	MP0003252_abnormal_bile_duct	0.70177428
96	MP0000703_abnormal_thymus_morphology	0.69649586
97	MP0001533_abnormal_skeleton_physiology	0.69108527
98	MP0009697_abnormal_copulation	0.67250586
99	MP0001929_abnormal_gametogenesis	0.65833539
100	MP0002075_abnormal_coat/hair_pigmentati	0.65030037

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	4.46792868
2	Abnormality of T cell number (HP:0011839)	4.27238164
3	Congenital stationary night blindness (HP:0007642)	4.13786817
4	Hepatic necrosis (HP:0002605)	3.97035418
5	IgG deficiency (HP:0004315)	3.82228641
6	Hepatocellular necrosis (HP:0001404)	3.66050538
7	Mitochondrial inheritance (HP:0001427)	3.53878873
8	Abnormality of T cells (HP:0002843)	3.53303576
9	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.50510918
10	Type 2 muscle fiber atrophy (HP:0003554)	3.49896048
11	Acute necrotizing encephalopathy (HP:0006965)	3.45510947
12	Abnormality of T cell physiology (HP:0011840)	3.26873900
13	Hypoglycemic seizures (HP:0002173)	3.26507539
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.19770582
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.19770582
16	Muscle fiber atrophy (HP:0100295)	3.13032377
17	Abnormality of the prostate (HP:0008775)	3.12037685
18	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.11515601
19	Dicarboxylic aciduria (HP:0003215)	3.11515601
20	Progressive macrocephaly (HP:0004481)	3.09092763
21	Abnormal mitochondria in muscle tissue (HP:0008316)	3.04230434
22	Increased CSF lactate (HP:0002490)	3.04007513
23	3-Methylglutaconic aciduria (HP:0003535)	2.90323572
24	Panhypogammaglobulinemia (HP:0003139)	2.87328765
25	Large for gestational age (HP:0001520)	2.84560242
26	Thyroiditis (HP:0100646)	2.82452232
27	Hypothermia (HP:0002045)	2.74277366
28	Recurrent viral infections (HP:0004429)	2.74251552
29	Chronic mucocutaneous candidiasis (HP:0002728)	2.70179011
30	Recurrent cutaneous fungal infections (HP:0011370)	2.70179011
31	Hypoglycemic coma (HP:0001325)	2.69907360
32	Acute encephalopathy (HP:0006846)	2.62789049
33	Cerebral edema (HP:0002181)	2.62511268
34	Severe combined immunodeficiency (HP:0004430)	2.61021369
35	Bundle branch block (HP:0011710)	2.58557971
36	Stomatitis (HP:0010280)	2.53123356
37	Testicular atrophy (HP:0000029)	2.52647077
38	Generalized aminoaciduria (HP:0002909)	2.51656239
39	Encephalitis (HP:0002383)	2.49971181
40	Autoimmune hemolytic anemia (HP:0001890)	2.48012351
41	Increased IgM level (HP:0003496)	2.45583347
42	Molar tooth sign on MRI (HP:0002419)	2.45435192
43	Abnormality of midbrain morphology (HP:0002418)	2.45435192
44	Chronic diarrhea (HP:0002028)	2.43094627
45	Methylmalonic aciduria (HP:0012120)	2.40649524
46	Symptomatic seizures (HP:0011145)	2.38634318
47	Abnormality of B cell number (HP:0010975)	2.35481177
48	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.33155854
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.31649486
50	Albinism (HP:0001022)	2.30435306
51	Hypoproteinemia (HP:0003075)	2.26534593
52	Aplastic anemia (HP:0001915)	2.23827838
53	Congenital, generalized hypertrichosis (HP:0004540)	2.21278558
54	Sensory axonal neuropathy (HP:0003390)	2.20596461
55	Combined immunodeficiency (HP:0005387)	2.15789566
56	Abolished electroretinogram (ERG) (HP:0000550)	2.15620893
57	Rectovaginal fistula (HP:0000143)	2.14578228
58	Rectal fistula (HP:0100590)	2.14578228
59	Methylmalonic acidemia (HP:0002912)	2.12051837
60	Hypokalemic alkalosis (HP:0001949)	2.11785405
61	Tongue fasciculations (HP:0001308)	2.09884702
62	Retrobulbar optic neuritis (HP:0100654)	2.07873838
63	Optic neuritis (HP:0100653)	2.07873838
64	Abnormality of lateral ventricle (HP:0030047)	2.07564572
65	Prostate neoplasm (HP:0100787)	2.06761809
66	Abnormality of eosinophils (HP:0001879)	2.06183965
67	Prominent metopic ridge (HP:0005487)	2.05344984
68	Palpitations (HP:0001962)	2.04688324
69	Lactic acidosis (HP:0003128)	2.02856987
70	Respiratory failure (HP:0002878)	2.02077735
71	Renal cortical cysts (HP:0000803)	2.01343859
72	Inflammation of the large intestine (HP:0002037)	1.98619556
73	Opisthotonus (HP:0002179)	1.94989824
74	Tetany (HP:0001281)	1.91403711
75	Poor speech (HP:0002465)	1.89476417
76	Facial diplegia (HP:0001349)	1.87907552
77	Type I transferrin isoform profile (HP:0003642)	1.86365996
78	Bile duct proliferation (HP:0001408)	1.84748456
79	Abnormal biliary tract physiology (HP:0012439)	1.84748456
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84117757
81	Abnormality of alanine metabolism (HP:0010916)	1.84117757
82	Hyperalaninemia (HP:0003348)	1.84117757
83	Increased serum lactate (HP:0002151)	1.83632998
84	Metabolic alkalosis (HP:0200114)	1.83441611
85	Pancreatitis (HP:0001733)	1.83207765
86	Clubbing of toes (HP:0100760)	1.82692791
87	Alkalosis (HP:0001948)	1.81729056
88	Severe visual impairment (HP:0001141)	1.81363281
89	Muscle fibrillation (HP:0010546)	1.81110715
90	Lethargy (HP:0001254)	1.81042966
91	Increased hepatocellular lipid droplets (HP:0006565)	1.78645023
92	Meningitis (HP:0001287)	1.78101028
93	Pancytopenia (HP:0001876)	1.78039199
94	Inability to walk (HP:0002540)	1.77935114
95	Elevated erythrocyte sedimentation rate (HP:0003565)	1.77726227
96	Recurrent fungal infections (HP:0002841)	1.77024488
97	Metaphyseal dysplasia (HP:0100255)	1.76706246
98	Abnormality of male internal genitalia (HP:0000022)	1.76093261
99	Increased circulating renin level (HP:0000848)	1.75609662
100	Eosinophilia (HP:0001880)	1.74921336

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.72920304
2	TXK	3.74667992
3	TLK1	3.50380209
4	ZAK	3.44312103
5	TESK2	3.21563852
6	FRK	2.93499848
7	KDR	2.92676028
8	TAOK3	2.73575176
9	SCYL2	2.42300168
10	CSF1R	2.14821484
11	BCKDK	2.07238559
12	LIMK1	2.05925675
13	ADRBK2	2.01720452
14	MST4	1.99120450
15	PHKG1	1.92861572
16	PHKG2	1.92861572
17	NEK1	1.92815714
18	MAP3K12	1.90151624
19	EIF2AK3	1.89120215
20	TESK1	1.86368464
21	GRK1	1.76031813
22	VRK2	1.63783325
23	KIT	1.61794528
24	WNK4	1.59354331
25	STK16	1.57431191
26	OXSR1	1.50112443
27	PASK	1.39305174
28	STK39	1.33465499
29	IKBKB	1.32761707
30	BUB1	1.32280043
31	IKBKE	1.30429207
32	VRK1	1.26265239
33	CDC7	1.24238616
34	ITK	1.19370100
35	PIK3CG	1.09844972
36	CHUK	1.07376510
37	CLK1	1.06894560
38	SYK	1.00521885
39	MYLK	0.95862253
40	BMPR1B	0.88429377
41	TRPM7	0.86045947
42	RPS6KA5	0.85052095
43	MAP4K1	0.81747707
44	TYK2	0.80777110
45	EIF2AK2	0.80758098
46	TIE1	0.78123983
47	CCNB1	0.74568718
48	NUAK1	0.73368140
49	CAMKK2	0.72628639
50	PDK2	0.72126988
51	PLK4	0.72076670
52	TBK1	0.71251509
53	TEC	0.71073107
54	MAP3K14	0.69506283
55	GRK6	0.68363523
56	INSRR	0.67234316
57	CDK19	0.66136009
58	BLK	0.64686693
59	TAOK2	0.60882821
60	DAPK2	0.58869230
61	JAK3	0.57768302
62	ADRBK1	0.54249631
63	DAPK1	0.54063811
64	WNK3	0.51749212
65	ROCK1	0.51611007
66	CSNK1A1L	0.51568461
67	OBSCN	0.50773778
68	MAPK13	0.48571744
69	AURKB	0.47835378
70	PRKCQ	0.47700411
71	LYN	0.47020528
72	IGF1R	0.45946480
73	BMPR2	0.45649283
74	FES	0.45018275
75	LCK	0.44721554
76	ABL1	0.43570360
77	IRAK3	0.42675063
78	JAK1	0.42531863
79	CSNK1G3	0.41355437
80	MAPK11	0.39322364
81	ILK	0.37443365
82	BRSK2	0.36993791
83	MAP2K6	0.36590596
84	IRAK4	0.35762530
85	CAMKK1	0.34976755
86	ERBB4	0.33235837
87	MAPKAPK3	0.33189423
88	ABL2	0.33050504
89	PRKCE	0.31605760
90	MAP2K2	0.30300752
91	PIK3CA	0.28405177
92	BRSK1	0.28168528
93	PLK3	0.28044161
94	PIM1	0.27836081
95	PRKCA	0.27527935
96	AURKA	0.26909990
97	TGFBR1	0.25222240
98	PRKCG	0.23124759
99	PINK1	0.22524958
100	PRKCD	0.22407148

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.07076112
2	Asthma_Homo sapiens_hsa05310	3.81017693
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.51323647
4	Allograft rejection_Homo sapiens_hsa05330	3.41142529
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.40141122
6	Antigen processing and presentation_Homo sapiens_hsa04612	3.31216179
7	Type I diabetes mellitus_Homo sapiens_hsa04940	3.23394457
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.22604100
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.89767304
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.71776075
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.33221700
12	Rheumatoid arthritis_Homo sapiens_hsa05323	2.33034878
13	Homologous recombination_Homo sapiens_hsa03440	2.31041564
14	Parkinsons disease_Homo sapiens_hsa05012	2.08780153
15	Nitrogen metabolism_Homo sapiens_hsa00910	2.07307516
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78489230
17	Viral myocarditis_Homo sapiens_hsa05416	1.66666320
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55953961
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54574620
20	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.51108841
21	Butanoate metabolism_Homo sapiens_hsa00650	1.44307795
22	Protein export_Homo sapiens_hsa03060	1.43862303
23	Alzheimers disease_Homo sapiens_hsa05010	1.42022924
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38793223
25	Basal transcription factors_Homo sapiens_hsa03022	1.36022960
26	Phototransduction_Homo sapiens_hsa04744	1.32707946
27	Mismatch repair_Homo sapiens_hsa03430	1.32639506
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.30509389
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.29590346
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27198350
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25396599
32	Leishmaniasis_Homo sapiens_hsa05140	1.24143198
33	Huntingtons disease_Homo sapiens_hsa05016	1.23089789
34	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17372571
35	DNA replication_Homo sapiens_hsa03030	1.14723683
36	Regulation of autophagy_Homo sapiens_hsa04140	1.05448134
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04999962
38	One carbon pool by folate_Homo sapiens_hsa00670	1.04857379
39	Ribosome_Homo sapiens_hsa03010	0.98222898
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96029173
41	RNA polymerase_Homo sapiens_hsa03020	0.95360117
42	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.89816017
43	RNA degradation_Homo sapiens_hsa03018	0.89771947
44	Fatty acid elongation_Homo sapiens_hsa00062	0.88480910
45	Purine metabolism_Homo sapiens_hsa00230	0.87449479
46	Propanoate metabolism_Homo sapiens_hsa00640	0.83855001
47	Circadian rhythm_Homo sapiens_hsa04710	0.82235448
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.79979345
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.79817214
50	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78346038
51	Olfactory transduction_Homo sapiens_hsa04740	0.77436271
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77362118
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75500208
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.70563642
55	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68846903
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68787356
57	Herpes simplex infection_Homo sapiens_hsa05168	0.67686694
58	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.66927815
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62546788
60	Peroxisome_Homo sapiens_hsa04146	0.60129202
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59217984
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57265724
63	Caffeine metabolism_Homo sapiens_hsa00232	0.54425202
64	Tuberculosis_Homo sapiens_hsa05152	0.52973121
65	Legionellosis_Homo sapiens_hsa05134	0.49404601
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47209796
67	Shigellosis_Homo sapiens_hsa05131	0.44753669
68	Fatty acid degradation_Homo sapiens_hsa00071	0.44735380
69	RNA transport_Homo sapiens_hsa03013	0.44334353
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43258505
71	Base excision repair_Homo sapiens_hsa03410	0.41694730
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39369925
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39293027
74	Glutathione metabolism_Homo sapiens_hsa00480	0.39200724
75	Salivary secretion_Homo sapiens_hsa04970	0.39049903
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39029937
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.38605488
78	Phagosome_Homo sapiens_hsa04145	0.37671554
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37501394
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.36514181
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34493883
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.33507504
83	Measles_Homo sapiens_hsa05162	0.32199387
84	Influenza A_Homo sapiens_hsa05164	0.30789204
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30208697
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29243748
87	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.28864345
88	Taste transduction_Homo sapiens_hsa04742	0.28815103
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.27674839
90	Metabolic pathways_Homo sapiens_hsa01100	0.26605252
91	Retinol metabolism_Homo sapiens_hsa00830	0.26527008
92	Toxoplasmosis_Homo sapiens_hsa05145	0.26209239
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22984340
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.22231544
95	Salmonella infection_Homo sapiens_hsa05132	0.21871286
96	Spliceosome_Homo sapiens_hsa03040	0.21767739
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.17822881
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.17620972
99	African trypanosomiasis_Homo sapiens_hsa05143	0.15760183
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.15227412

GYG1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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