ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	triglyceride catabolic process (GO:0019433)	6.62483037
2	low-density lipoprotein particle clearance (GO:0034383)	6.58584337
3	acylglycerol catabolic process (GO:0046464)	6.09350212
4	neutral lipid catabolic process (GO:0046461)	6.09350212
5	regulation of sequestering of triglyceride (GO:0010889)	5.19643089
6	fatty acid homeostasis (GO:0055089)	4.74561573
7	transcytosis (GO:0045056)	4.65847021
8	response to dietary excess (GO:0002021)	4.65278243
9	glycerolipid catabolic process (GO:0046503)	4.64379162
10	biotin metabolic process (GO:0006768)	4.32766101
11	paraxial mesoderm development (GO:0048339)	4.28600144
12	diacylglycerol metabolic process (GO:0046339)	4.08133897
13	protein heterotrimerization (GO:0070208)	3.78879030
14	L-serine metabolic process (GO:0006563)	3.70138221
15	plasma lipoprotein particle clearance (GO:0034381)	3.69668277
16	white fat cell differentiation (GO:0050872)	3.64872679
17	ethanol oxidation (GO:0006069)	3.62044859
18	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.61412805
19	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.60913864
20	regulation of cAMP-dependent protein kinase activity (GO:2000479)	3.59455259
21	response to phenylpropanoid (GO:0080184)	3.51110724
22	alpha-linolenic acid metabolic process (GO:0036109)	3.45911252
23	triglyceride biosynthetic process (GO:0019432)	3.44566727
24	CDP-diacylglycerol metabolic process (GO:0046341)	3.41288646
25	NADH metabolic process (GO:0006734)	3.39572882
26	lipid particle organization (GO:0034389)	3.37218546
27	acylglycerol biosynthetic process (GO:0046463)	3.30382751
28	neutral lipid biosynthetic process (GO:0046460)	3.30382751
29	polyol transport (GO:0015791)	3.26656109
30	regulation of gene silencing by RNA (GO:0060966)	3.26399872
31	regulation of posttranscriptional gene silencing (GO:0060147)	3.26399872
32	regulation of gene silencing by miRNA (GO:0060964)	3.26399872
33	positive regulation of glomerulus development (GO:0090193)	3.22317015
34	lung-associated mesenchyme development (GO:0060484)	3.21269097
35	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.13009395
36	ovulation from ovarian follicle (GO:0001542)	3.09069260
37	triglyceride metabolic process (GO:0006641)	3.08581728
38	regulation of glycogen (starch) synthase activity (GO:2000465)	2.98711220
39	lipid storage (GO:0019915)	2.96003222
40	negative regulation of DNA biosynthetic process (GO:2000279)	2.94928500
41	fatty-acyl-CoA metabolic process (GO:0035337)	2.91282359
42	protein localization to cell surface (GO:0034394)	2.88832024
43	short-term memory (GO:0007614)	2.87539850
44	acylglycerol metabolic process (GO:0006639)	2.87280347
45	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.86273879
46	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.86123717
47	acylglycerol homeostasis (GO:0055090)	2.85592151
48	triglyceride homeostasis (GO:0070328)	2.85592151
49	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.84758088
50	neutral lipid metabolic process (GO:0006638)	2.82335514
51	brown fat cell differentiation (GO:0050873)	2.81503788
52	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.80670386
53	negative regulation of amino acid transport (GO:0051956)	2.78850729
54	response to nitrosative stress (GO:0051409)	2.77782666
55	ethanol metabolic process (GO:0006067)	2.77396031
56	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.77261202
57	serine family amino acid catabolic process (GO:0009071)	2.75579986
58	positive regulation of glucose import (GO:0046326)	2.74960441
59	acyl-CoA biosynthetic process (GO:0071616)	2.74434633
60	thioester biosynthetic process (GO:0035384)	2.74434633
61	primary alcohol metabolic process (GO:0034308)	2.73693107
62	axon extension involved in axon guidance (GO:0048846)	2.73534164
63	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.73534164
64	regulation of gonadotropin secretion (GO:0032276)	2.72902456
65	regulation of lipoprotein metabolic process (GO:0050746)	2.72718282
66	acetyl-CoA metabolic process (GO:0006084)	2.72660372
67	regulation of cholesterol storage (GO:0010885)	2.71368533
68	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.70646921
69	cellular response to leptin stimulus (GO:0044320)	2.70147188
70	tricarboxylic acid metabolic process (GO:0072350)	2.65036145
71	acyl-CoA metabolic process (GO:0006637)	2.64522601
72	thioester metabolic process (GO:0035383)	2.64522601
73	negative regulation of norepinephrine secretion (GO:0010700)	2.64244700
74	negative regulation of response to food (GO:0032096)	2.64020735
75	negative regulation of appetite (GO:0032099)	2.64020735
76	endothelial cell morphogenesis (GO:0001886)	2.61538941
77	regulation of cell fate specification (GO:0042659)	2.60264736
78	cGMP-mediated signaling (GO:0019934)	2.59181078
79	pre-miRNA processing (GO:0031054)	2.59134269
80	glycine metabolic process (GO:0006544)	2.57916442
81	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.56183712
82	glycerol metabolic process (GO:0006071)	2.55435849
83	oxaloacetate metabolic process (GO:0006107)	2.54411648
84	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.53106288
85	primary alcohol catabolic process (GO:0034310)	2.49071434
86	positive regulation of glycolytic process (GO:0045821)	2.47259475
87	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.45413909
88	negative regulation of macrophage differentiation (GO:0045650)	2.43826609
89	positive regulation of triglyceride lipase activity (GO:0061365)	2.43196526
90	positive regulation of lipoprotein lipase activity (GO:0051006)	2.43196526
91	positive regulation of lipid storage (GO:0010884)	2.43141787
92	positive regulation of cholesterol efflux (GO:0010875)	2.43049891
93	regulation of gastrulation (GO:0010470)	2.42231301
94	notochord development (GO:0030903)	2.40991949
95	positive regulation of glucose transport (GO:0010828)	2.40500128
96	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.35618312
97	lysine metabolic process (GO:0006553)	2.33502402
98	lysine catabolic process (GO:0006554)	2.33502402
99	fatty acid beta-oxidation (GO:0006635)	2.32403506
100	outer ear morphogenesis (GO:0042473)	2.31893612

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	6.36918525
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.66976653
3	CLOCK_20551151_ChIP-Seq_293T_Human	2.46236274
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.44489543
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.40440453
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.40440453
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.40440453
8	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	2.31126378
9	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.30988279
10	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.17390754
11	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.16498385
12	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.12792425
13	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.12397163
14	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.02093534
15	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.00990799
16	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.99080458
17	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.88738383
18	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.86734475
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.85647378
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76143315
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.73013498
22	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.69998120
23	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.66892988
24	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.64605763
25	E2F7_22180533_ChIP-Seq_HELA_Human	1.58132162
26	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.54734230
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.53221519
28	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.52657026
29	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.49801464
30	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.48562004
31	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.47862714
32	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.45646083
33	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.43349798
34	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.42828782
35	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.41288275
36	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.39575655
37	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.39039201
38	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35582864
39	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35582864
40	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.34611412
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33141535
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32833537
43	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.30755700
44	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.29160546
45	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.26124045
46	AR_21909140_ChIP-Seq_LNCAP_Human	1.22481157
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.19023464
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.18225214
49	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.15027714
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.14784430
51	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.14391951
52	GBX2_23144817_ChIP-Seq_PC3_Human	1.14226742
53	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.12155695
54	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	1.09690960
55	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	1.09684408
56	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08731496
57	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.05787767
58	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.05119433
59	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.04842867
60	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.04621936
61	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.04254571
62	SOX2_18692474_ChIP-Seq_MEFs_Mouse	1.04157403
63	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.02369724
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.01998153
65	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.00383431
66	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.98988921
67	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.98910372
68	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.98841848
69	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.96524556
70	P300_19829295_ChIP-Seq_ESCs_Human	0.95609685
71	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.93965888
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.93892500
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93594030
74	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93565119
75	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.91645609
76	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.91407351
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.91194877
78	NANOG_16518401_ChIP-PET_MESCs_Mouse	0.90202129
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.89540605
80	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.88667093
81	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.87883411
82	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.87702190
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87053684
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86976443
85	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.85243405
86	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.85205898
87	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.84991858
88	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.84751017
89	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.84243550
90	RNF2_27304074_Chip-Seq_NSC_Mouse	0.83978516
91	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.83960969
92	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83211721
93	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.82366752
94	SOX9_26525672_Chip-Seq_HEART_Mouse	0.82197340
95	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.81582656
96	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.81571969
97	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.81372967
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.81330382
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.80999376
100	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.80996104

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	6.00513796
2	MP0005666_abnormal_adipose_tissue	4.04534118
3	MP0004130_abnormal_muscle_cell	2.92701899
4	MP0005375_adipose_tissue_phenotype	2.76610556
5	MP0004185_abnormal_adipocyte_glucose	2.74233404
6	MP0002971_abnormal_brown_adipose	2.69867929
7	MP0003136_yellow_coat_color	2.29209248
8	MP0010030_abnormal_orbit_morphology	2.25824861
9	MP0003122_maternal_imprinting	2.20901140
10	MP0010329_abnormal_lipoprotein_level	2.11948578
11	MP0009672_abnormal_birth_weight	1.95538773
12	MP0009115_abnormal_fat_cell	1.94743292
13	MP0003011_delayed_dark_adaptation	1.90186824
14	MP0002876_abnormal_thyroid_physiology	1.75172364
15	MP0000566_synostosis	1.74415940
16	MP0003959_abnormal_lean_body	1.72967936
17	MP0004272_abnormal_basement_membrane	1.69107149
18	MP0003186_abnormal_redox_activity	1.68979828
19	MP0002638_abnormal_pupillary_reflex	1.63919121
20	MP0002970_abnormal_white_adipose	1.63760385
21	MP0006138_congestive_heart_failure	1.61589356
22	MP0003890_abnormal_embryonic-extraembry	1.57799093
23	MP0003567_abnormal_fetal_cardiomyocyte	1.56502269
24	MP0003941_abnormal_skin_development	1.55580048
25	MP0001299_abnormal_eye_distance/	1.52667873
26	MP0005334_abnormal_fat_pad	1.51838601
27	MP0006292_abnormal_olfactory_placode	1.50240469
28	MP0002909_abnormal_adrenal_gland	1.43543834
29	MP0005379_endocrine/exocrine_gland_phen	1.41701684
30	MP0002254_reproductive_system_inflammat	1.40476553
31	MP0001293_anophthalmia	1.39004902
32	MP0006276_abnormal_autonomic_nervous	1.37177781
33	MP0004133_heterotaxia	1.36493442
34	MP0000003_abnormal_adipose_tissue	1.33667869
35	MP0005171_absent_coat_pigmentation	1.33415070
36	MP0002697_abnormal_eye_size	1.29007077
37	MP0002938_white_spotting	1.27486408
38	MP0005503_abnormal_tendon_morphology	1.24453463
39	MP0003868_abnormal_feces_composition	1.24038364
40	MP0003878_abnormal_ear_physiology	1.23485429
41	MP0005377_hearing/vestibular/ear_phenot	1.23485429
42	MP0002233_abnormal_nose_morphology	1.19338188
43	MP0009703_decreased_birth_body	1.18336445
44	MP0002108_abnormal_muscle_morphology	1.13105147
45	MP0003119_abnormal_digestive_system	1.12909887
46	MP0005448_abnormal_energy_balance	1.12281553
47	MP0000372_irregular_coat_pigmentation	1.10501062
48	MP0005535_abnormal_body_temperature	1.09890073
49	MP0002118_abnormal_lipid_homeostasis	1.09785313
50	MP0003690_abnormal_glial_cell	1.09692389
51	MP0003937_abnormal_limbs/digits/tail_de	1.09122794
52	MP0001177_atelectasis	1.08964632
53	MP0001661_extended_life_span	1.06853687
54	MP0005452_abnormal_adipose_tissue	1.06147117
55	MP0000751_myopathy	1.06006457
56	MP0003121_genomic_imprinting	1.03098004
57	MP0000778_abnormal_nervous_system	1.01111303
58	MP0001984_abnormal_olfaction	0.99403803
59	MP0003942_abnormal_urinary_system	0.97736561
60	MP0008438_abnormal_cutaneous_collagen	0.94259786
61	MP0003283_abnormal_digestive_organ	0.92911856
62	MP0005394_taste/olfaction_phenotype	0.92874069
63	MP0005499_abnormal_olfactory_system	0.92874069
64	MP0000049_abnormal_middle_ear	0.90871947
65	MP0003123_paternal_imprinting	0.90811983
66	MP0005257_abnormal_intraocular_pressure	0.90095923
67	MP0002295_abnormal_pulmonary_circulatio	0.88379410
68	MP0003385_abnormal_body_wall	0.87032641
69	MP0008932_abnormal_embryonic_tissue	0.86866250
70	MP0001286_abnormal_eye_development	0.84261203
71	MP0002111_abnormal_tail_morphology	0.83122989
72	MP0000428_abnormal_craniofacial_morphol	0.82543390
73	MP0001544_abnormal_cardiovascular_syste	0.81862156
74	MP0005385_cardiovascular_system_phenoty	0.81862156
75	MP0003705_abnormal_hypodermis_morpholog	0.81474206
76	MP0003948_abnormal_gas_homeostasis	0.81270518
77	MP0005408_hypopigmentation	0.80379454
78	MP0005365_abnormal_bile_salt	0.79378218
79	MP0005275_abnormal_skin_tensile	0.78889106
80	MP0004215_abnormal_myocardial_fiber	0.77521782
81	MP0008789_abnormal_olfactory_epithelium	0.74868893
82	MP0003938_abnormal_ear_development	0.71902892
83	MP0002090_abnormal_vision	0.71849096
84	MP0002084_abnormal_developmental_patter	0.71042448
85	MP0002078_abnormal_glucose_homeostasis	0.69899999
86	MP0002085_abnormal_embryonic_tissue	0.69796817
87	MP0003861_abnormal_nervous_system	0.67016011
88	MP0003755_abnormal_palate_morphology	0.66759404
89	MP0002092_abnormal_eye_morphology	0.65919079
90	MP0001529_abnormal_vocalization	0.63548756
91	MP0005167_abnormal_blood-brain_barrier	0.63511123
92	MP0005508_abnormal_skeleton_morphology	0.63183616
93	MP0009780_abnormal_chondrocyte_physiolo	0.62761652
94	MP0001727_abnormal_embryo_implantation	0.61877675
95	MP0004087_abnormal_muscle_fiber	0.61033075
96	MP0001764_abnormal_homeostasis	0.60901207
97	MP0001324_abnormal_eye_pigmentation	0.59233070
98	MP0003137_abnormal_impulse_conducting	0.59029397
99	MP0009053_abnormal_anal_canal	0.58725884
100	MP0004858_abnormal_nervous_system	0.58659471

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligomenorrhea (HP:0000876)	5.00358534
2	Hepatoblastoma (HP:0002884)	3.69731004
3	Acanthosis nigricans (HP:0000956)	3.50046764
4	Cortical dysplasia (HP:0002539)	3.35852971
5	Abnormality of the labia minora (HP:0012880)	3.18444175
6	Hypertriglyceridemia (HP:0002155)	3.18251618
7	Hyperglycinemia (HP:0002154)	3.17784472
8	Septo-optic dysplasia (HP:0100842)	2.90318386
9	Turricephaly (HP:0000262)	2.90017462
10	Choanal stenosis (HP:0000452)	2.88652178
11	Shallow orbits (HP:0000586)	2.78065408
12	Coronal craniosynostosis (HP:0004440)	2.70125422
13	Increased serum pyruvate (HP:0003542)	2.68396145
14	Protrusio acetabuli (HP:0003179)	2.56471721
15	Long foot (HP:0001833)	2.53575424
16	Broad metatarsal (HP:0001783)	2.52007429
17	Hyperglycinuria (HP:0003108)	2.48282871
18	Abnormality of glycolysis (HP:0004366)	2.37681070
19	Abnormality of serine family amino acid metabolism (HP:0010894)	2.37019494
20	Abnormality of glycine metabolism (HP:0010895)	2.37019494
21	Polyphagia (HP:0002591)	2.36297665
22	Pancreatic islet-cell hyperplasia (HP:0004510)	2.30583268
23	Insulin resistance (HP:0000855)	2.24115315
24	Colon cancer (HP:0003003)	2.23580269
25	Epidermoid cyst (HP:0200040)	2.22792922
26	Hypercholesterolemia (HP:0003124)	2.21399142
27	Abnormal eating behavior (HP:0100738)	2.18249431
28	Maternal diabetes (HP:0009800)	2.17873817
29	Back pain (HP:0003418)	2.15459937
30	Abnormality of serum amino acid levels (HP:0003112)	2.10808586
31	Partial duplication of thumb phalanx (HP:0009944)	2.10065823
32	Prominent supraorbital ridges (HP:0000336)	2.09957833
33	Aplasia involving bones of the upper limbs (HP:0009823)	2.08792357
34	Aplasia of the phalanges of the hand (HP:0009802)	2.08792357
35	Aplasia involving bones of the extremities (HP:0009825)	2.08792357
36	Impulsivity (HP:0100710)	2.08620323
37	Difficulty running (HP:0009046)	2.06015717
38	Partial duplication of the phalanx of hand (HP:0009999)	2.05785461
39	Ectopia lentis (HP:0001083)	2.00762504
40	Preaxial foot polydactyly (HP:0001841)	1.95790979
41	High anterior hairline (HP:0009890)	1.95457175
42	Bronchomalacia (HP:0002780)	1.95110848
43	Abnormality of the middle phalanges of the toes (HP:0010183)	1.94941012
44	Spastic diplegia (HP:0001264)	1.91326543
45	Abnormal lung lobation (HP:0002101)	1.91098259
46	Humeroradial synostosis (HP:0003041)	1.90340686
47	Synostosis involving the elbow (HP:0003938)	1.90340686
48	Short hallux (HP:0010109)	1.83811467
49	Absent eyebrow (HP:0002223)	1.83743081
50	Broad long bones (HP:0005622)	1.81963503
51	Bilateral microphthalmos (HP:0007633)	1.81137833
52	Broad phalanx (HP:0006009)	1.80726414
53	Generalized hypotonia (HP:0001290)	1.80642418
54	Hyperlipoproteinemia (HP:0010980)	1.79861014
55	Broad foot (HP:0001769)	1.79830620
56	Increased variability in muscle fiber diameter (HP:0003557)	1.79032951
57	Nephroblastoma (Wilms tumor) (HP:0002667)	1.76900536
58	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.76301507
59	Hypoglycemic coma (HP:0001325)	1.75007246
60	Lymphangioma (HP:0100764)	1.74985755
61	Myelomeningocele (HP:0002475)	1.74850675
62	Anophthalmia (HP:0000528)	1.74485987
63	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.74069979
64	Cutaneous finger syndactyly (HP:0010554)	1.73576313
65	Trigonocephaly (HP:0000243)	1.73316190
66	Cutaneous syndactyly (HP:0012725)	1.73056240
67	Hypoglycemic seizures (HP:0002173)	1.72585547
68	Bifid tongue (HP:0010297)	1.71686847
69	Broad thumb (HP:0011304)	1.69764320
70	Skin nodule (HP:0200036)	1.69156245
71	Embryonal renal neoplasm (HP:0011794)	1.68315024
72	Complement deficiency (HP:0004431)	1.67243393
73	Broad finger (HP:0001500)	1.63678220
74	Intestinal atresia (HP:0011100)	1.63647887
75	Enlarged penis (HP:0000040)	1.63336598
76	Abnormality of the labia (HP:0000058)	1.62754975
77	Vitreoretinal degeneration (HP:0000655)	1.62735017
78	Bicornuate uterus (HP:0000813)	1.62587276
79	Abdominal situs inversus (HP:0003363)	1.62520509
80	Abnormality of abdominal situs (HP:0011620)	1.62520509
81	Broad phalanges of the hand (HP:0009768)	1.61884652
82	Large hands (HP:0001176)	1.60782957
83	Skull defect (HP:0001362)	1.60387849
84	Abnormality of the lower motor neuron (HP:0002366)	1.59811199
85	Alacrima (HP:0000522)	1.59700248
86	Absent septum pellucidum (HP:0001331)	1.59304189
87	Absent eyelashes (HP:0000561)	1.59247286
88	Megalocornea (HP:0000485)	1.59040436
89	Infantile muscular hypotonia (HP:0008947)	1.56266015
90	Fused cervical vertebrae (HP:0002949)	1.56227539
91	Hemivertebrae (HP:0002937)	1.55804112
92	Hypoalphalipoproteinemia (HP:0003233)	1.52981355
93	White forelock (HP:0002211)	1.51340042
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.49626585
95	Abnormality of alanine metabolism (HP:0010916)	1.49626585
96	Hyperalaninemia (HP:0003348)	1.49626585
97	Clitoromegaly (HP:0000057)	1.49541510
98	Gonadotropin excess (HP:0000837)	1.49338967
99	Increased muscle lipid content (HP:0009058)	1.49007668
100	Omphalocele (HP:0001539)	1.48735397

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	2.65829906
2	TNIK	2.65250554
3	TIE1	2.63848053
4	FGFR2	2.35221360
5	TTK	2.31239154
6	WNK3	2.26296699
7	LATS2	2.20994974
8	MKNK1	2.20389934
9	CDC7	2.09554113
10	LATS1	1.96142451
11	DDR2	1.94787573
12	CASK	1.93749752
13	MKNK2	1.91511835
14	NTRK1	1.76037344
15	TYRO3	1.75479914
16	PLK4	1.74046258
17	DYRK2	1.73988934
18	NEK1	1.73291521
19	CAMK1D	1.72599008
20	NEK2	1.68124202
21	RIPK1	1.64863233
22	CAMK1G	1.62297657
23	MARK1	1.60629376
24	STK38L	1.56553280
25	BUB1	1.46436785
26	CAMK1	1.45847221
27	PLK3	1.40130522
28	MAP3K4	1.37815754
29	PDGFRA	1.30332321
30	PRKAA2	1.27865234
31	WEE1	1.23034925
32	FGFR1	1.18573803
33	TSSK6	1.14149675
34	NTRK2	1.13799256
35	SRPK1	1.06547772
36	PRKD3	1.04979108
37	DYRK3	1.03344720
38	STK3	1.03075051
39	CDK19	1.01544567
40	STK16	1.01363638
41	NLK	1.00389470
42	EEF2K	0.96312708
43	CSNK1G2	0.95678512
44	BCR	0.94695758
45	FGFR4	0.93689853
46	PLK1	0.93342023
47	CSNK1G1	0.93272284
48	PDK2	0.92195933
49	EPHA4	0.92117891
50	ERBB4	0.91441312
51	CDK6	0.88081007
52	MAP3K9	0.83965203
53	TRIM28	0.83646750
54	MAP2K7	0.83466427
55	ALK	0.83211044
56	PNCK	0.78751049
57	TAF1	0.76668479
58	TRIB3	0.75241524
59	PRKCG	0.73896914
60	ABL2	0.71854300
61	MINK1	0.70711371
62	PRKAA1	0.69508943
63	CSNK1E	0.69248313
64	DYRK1A	0.68400324
65	DMPK	0.64761114
66	MYLK	0.63863878
67	ZAK	0.62995826
68	PAK4	0.62105543
69	PRKACB	0.60813248
70	PAK2	0.60421892
71	MAP3K6	0.60105175
72	AKT2	0.59812029
73	PRKACG	0.58489081
74	PLK2	0.57553242
75	GRK5	0.54154606
76	PINK1	0.53751216
77	ATM	0.53577154
78	SIK1	0.52633845
79	PRKDC	0.51775040
80	SGK494	0.50584800
81	SGK223	0.50584800
82	GSK3A	0.49345037
83	PRKG1	0.49321647
84	CDK11A	0.48024304
85	BRSK1	0.47770341
86	CSNK1G3	0.47437243
87	CDK18	0.47337803
88	CDK15	0.46912486
89	CDK3	0.46176458
90	PKN1	0.46161199
91	BRSK2	0.45841230
92	MAPK4	0.45656268
93	CDK5	0.44335174
94	NTRK3	0.43628694
95	ERBB2	0.43315040
96	YES1	0.42842457
97	TGFBR2	0.42247156
98	GRK1	0.41798409
99	CDK1	0.41221629
100	BMPR1B	0.40621292

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.54241151
2	PPAR signaling pathway_Homo sapiens_hsa03320	2.89555576
3	Pyruvate metabolism_Homo sapiens_hsa00620	2.79594048
4	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	2.79513994
5	Fatty acid elongation_Homo sapiens_hsa00062	2.54187271
6	Propanoate metabolism_Homo sapiens_hsa00640	2.49195094
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.47900489
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.43359185
9	Fatty acid degradation_Homo sapiens_hsa00071	2.33025158
10	Fatty acid metabolism_Homo sapiens_hsa01212	2.24048527
11	Phenylalanine metabolism_Homo sapiens_hsa00360	2.21047010
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.12350883
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.11489065
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.09542079
15	Glycerolipid metabolism_Homo sapiens_hsa00561	2.02884334
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97098470
17	Tyrosine metabolism_Homo sapiens_hsa00350	1.88758995
18	beta-Alanine metabolism_Homo sapiens_hsa00410	1.82813904
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.80436552
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73184789
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.69984605
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.63243543
23	Histidine metabolism_Homo sapiens_hsa00340	1.47039124
24	Carbon metabolism_Homo sapiens_hsa01200	1.38274962
25	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.38156159
26	Butanoate metabolism_Homo sapiens_hsa00650	1.37781210
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.35426844
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.32459664
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26624540
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.23225773
31	AMPK signaling pathway_Homo sapiens_hsa04152	1.19637084
32	Lysine degradation_Homo sapiens_hsa00310	1.17282653
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.17028725
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13193794
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12882818
36	Retinol metabolism_Homo sapiens_hsa00830	1.11385264
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.10287401
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00888602
39	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93538743
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.90253675
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.87040839
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84036659
43	Glutathione metabolism_Homo sapiens_hsa00480	0.81725297
44	Folate biosynthesis_Homo sapiens_hsa00790	0.80682719
45	Hippo signaling pathway_Homo sapiens_hsa04390	0.79989451
46	One carbon pool by folate_Homo sapiens_hsa00670	0.79933292
47	Adherens junction_Homo sapiens_hsa04520	0.79248615
48	Peroxisome_Homo sapiens_hsa04146	0.78608109
49	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.77992058
50	ECM-receptor interaction_Homo sapiens_hsa04512	0.77674777
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76575503
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74660267
53	Arginine biosynthesis_Homo sapiens_hsa00220	0.71904712
54	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.68497949
55	Wnt signaling pathway_Homo sapiens_hsa04310	0.67779569
56	Mismatch repair_Homo sapiens_hsa03430	0.67399735
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66737598
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.65951160
59	Sulfur relay system_Homo sapiens_hsa04122	0.65334761
60	Tight junction_Homo sapiens_hsa04530	0.62224823
61	Melanogenesis_Homo sapiens_hsa04916	0.57930284
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56536492
63	Insulin signaling pathway_Homo sapiens_hsa04910	0.52396831
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.51596756
65	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50509605
66	RNA polymerase_Homo sapiens_hsa03020	0.49451808
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49389211
68	Axon guidance_Homo sapiens_hsa04360	0.49271481
69	DNA replication_Homo sapiens_hsa03030	0.49082429
70	Parkinsons disease_Homo sapiens_hsa05012	0.47620132
71	Metabolic pathways_Homo sapiens_hsa01100	0.46057867
72	Glucagon signaling pathway_Homo sapiens_hsa04922	0.44892311
73	Spliceosome_Homo sapiens_hsa03040	0.44349945
74	RNA transport_Homo sapiens_hsa03013	0.44165652
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43473790
76	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.43449009
77	Complement and coagulation cascades_Homo sapiens_hsa04610	0.43310083
78	Cell cycle_Homo sapiens_hsa04110	0.42235680
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.42105028
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.41137277
81	Bile secretion_Homo sapiens_hsa04976	0.41044709
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.40069990
83	Thyroid cancer_Homo sapiens_hsa05216	0.39334857
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39050575
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37223085
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36913609
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.35602014
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35566856
89	Huntingtons disease_Homo sapiens_hsa05016	0.34692472
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34299137
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.34229873
92	Oocyte meiosis_Homo sapiens_hsa04114	0.32036904
93	Protein export_Homo sapiens_hsa03060	0.31895466
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.30246891
95	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.28256791
96	Notch signaling pathway_Homo sapiens_hsa04330	0.26764939
97	Base excision repair_Homo sapiens_hsa03410	0.25457736
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.25385759
99	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23053582
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.22838495

GYG2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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