ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.86203549
2	indole-containing compound catabolic process (GO:0042436)	4.43019853
3	indolalkylamine catabolic process (GO:0046218)	4.43019853
4	tryptophan catabolic process (GO:0006569)	4.43019853
5	kynurenine metabolic process (GO:0070189)	4.39087159
6	indolalkylamine metabolic process (GO:0006586)	4.37744819
7	L-fucose catabolic process (GO:0042355)	3.97870432
8	fucose catabolic process (GO:0019317)	3.97870432
9	L-fucose metabolic process (GO:0042354)	3.97870432
10	detection of light stimulus involved in sensory perception (GO:0050962)	3.94147604
11	detection of light stimulus involved in visual perception (GO:0050908)	3.94147604
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.77784461
13	cornea development in camera-type eye (GO:0061303)	3.69722082
14	tryptophan metabolic process (GO:0006568)	3.66296985
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.62255641
16	platelet dense granule organization (GO:0060155)	3.55782687
17	neural tube formation (GO:0001841)	3.51777180
18	DNA deamination (GO:0045006)	3.51698521
19	response to pheromone (GO:0019236)	3.50620535
20	cellular biogenic amine catabolic process (GO:0042402)	3.32912077
21	amine catabolic process (GO:0009310)	3.32912077
22	indole-containing compound metabolic process (GO:0042430)	3.32813349
23	respiratory chain complex IV assembly (GO:0008535)	3.29372655
24	epithelial cilium movement (GO:0003351)	3.24501398
25	cellular ketone body metabolic process (GO:0046950)	3.23428948
26	oxidative demethylation (GO:0070989)	3.18559327
27	protein-cofactor linkage (GO:0018065)	3.15478053
28	protein complex biogenesis (GO:0070271)	3.15113256
29	photoreceptor cell maintenance (GO:0045494)	3.12403238
30	cilium or flagellum-dependent cell motility (GO:0001539)	3.10949015
31	axoneme assembly (GO:0035082)	3.08433510
32	regulation of action potential (GO:0098900)	3.08420269
33	gamma-aminobutyric acid transport (GO:0015812)	3.04225570
34	nonmotile primary cilium assembly (GO:0035058)	3.04164710
35	piRNA metabolic process (GO:0034587)	3.01159835
36	cytochrome complex assembly (GO:0017004)	3.00120514
37	protein localization to cilium (GO:0061512)	2.99036821
38	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98583103
39	negative regulation of mast cell activation (GO:0033004)	2.94903848
40	reflex (GO:0060004)	2.92817679
41	ketone body metabolic process (GO:1902224)	2.90389084
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.89015014
43	NADH dehydrogenase complex assembly (GO:0010257)	2.89015014
44	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.89015014
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.87890263
46	tachykinin receptor signaling pathway (GO:0007217)	2.86745005
47	sulfation (GO:0051923)	2.86158583
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85809895
49	aromatic amino acid family catabolic process (GO:0009074)	2.85549836
50	neuronal action potential (GO:0019228)	2.84909769
51	primary amino compound metabolic process (GO:1901160)	2.82723802
52	retinal cone cell development (GO:0046549)	2.82280280
53	cilium movement (GO:0003341)	2.82193278
54	water-soluble vitamin biosynthetic process (GO:0042364)	2.81560290
55	DNA methylation involved in gamete generation (GO:0043046)	2.79846401
56	rhodopsin mediated signaling pathway (GO:0016056)	2.75959722
57	protein K11-linked deubiquitination (GO:0035871)	2.75761961
58	behavioral response to ethanol (GO:0048149)	2.75532743
59	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.73864060
60	auditory receptor cell stereocilium organization (GO:0060088)	2.73491223
61	serotonin metabolic process (GO:0042428)	2.73259920
62	cilium organization (GO:0044782)	2.72789850
63	protein polyglutamylation (GO:0018095)	2.70546211
64	DNA double-strand break processing (GO:0000729)	2.70056462
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69068270
66	signal peptide processing (GO:0006465)	2.68716705
67	reciprocal meiotic recombination (GO:0007131)	2.67533869
68	reciprocal DNA recombination (GO:0035825)	2.67533869
69	replication fork processing (GO:0031297)	2.67525076
70	regulation of hexokinase activity (GO:1903299)	2.67439171
71	regulation of glucokinase activity (GO:0033131)	2.67439171
72	benzene-containing compound metabolic process (GO:0042537)	2.66803472
73	cilium morphogenesis (GO:0060271)	2.65807120
74	adult feeding behavior (GO:0008343)	2.64236642
75	cilium assembly (GO:0042384)	2.63742301
76	regulation of hippo signaling (GO:0035330)	2.63640097
77	negative regulation of telomere maintenance (GO:0032205)	2.59732485
78	photoreceptor cell development (GO:0042461)	2.59229617
79	multicellular organism reproduction (GO:0032504)	2.57023881
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.55362501
81	C4-dicarboxylate transport (GO:0015740)	2.54536498
82	protein neddylation (GO:0045116)	2.53835655
83	transmission of nerve impulse (GO:0019226)	2.53736569
84	pyrimidine nucleobase catabolic process (GO:0006208)	2.52731747
85	DNA demethylation (GO:0080111)	2.52458999
86	regulation of neurotransmitter uptake (GO:0051580)	2.52424475
87	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.52180702
88	intraciliary transport (GO:0042073)	2.45978054
89	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.45467095
90	aromatic amino acid family metabolic process (GO:0009072)	2.45012786
91	thyroid hormone metabolic process (GO:0042403)	2.41953667
92	neuronal action potential propagation (GO:0019227)	2.41847162
93	amino acid salvage (GO:0043102)	2.41590283
94	L-methionine salvage (GO:0071267)	2.41590283
95	L-methionine biosynthetic process (GO:0071265)	2.41590283
96	glycerophospholipid catabolic process (GO:0046475)	2.41126647
97	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.38788024
98	recombinational repair (GO:0000725)	2.38545835
99	adaptation of signaling pathway (GO:0023058)	2.37837780
100	inner ear receptor stereocilium organization (GO:0060122)	2.37381742

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.64934616
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.37865287
3	VDR_22108803_ChIP-Seq_LS180_Human	3.04576348
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.00397843
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.99742406
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.76035758
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.70813091
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.51294260
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.39521521
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.39054373
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.38338863
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.17827548
13	EWS_26573619_Chip-Seq_HEK293_Human	2.10284845
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09373068
15	FUS_26573619_Chip-Seq_HEK293_Human	2.08891568
16	P300_19829295_ChIP-Seq_ESCs_Human	2.06459135
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97885296
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.92261945
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83099091
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81530582
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79768890
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.79495716
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.78292781
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72030355
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.69030364
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64053975
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61093887
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.61093887
29	STAT3_23295773_ChIP-Seq_U87_Human	1.61058465
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.59853307
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59065608
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.55793465
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53174652
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51214255
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.50772002
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48802462
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47925576
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47765105
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47319297
40	TCF4_23295773_ChIP-Seq_U87_Human	1.47068912
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45659444
42	AR_25329375_ChIP-Seq_VCAP_Human	1.45486232
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44708969
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42150591
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40120146
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39456432
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38229592
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36576595
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36576595
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36465051
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36134856
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36013969
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.35825354
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.35340706
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34777133
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31236311
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31072861
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31072861
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30897108
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30055127
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28311339
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.25753040
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24889962
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22401969
65	NCOR_22424771_ChIP-Seq_293T_Human	1.21886816
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21450055
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21450055
68	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20795917
69	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20259079
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20166418
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18983355
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.17408250
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17294077
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16992272
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16504552
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.13740375
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12551549
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12408944
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12253563
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12204980
81	AR_20517297_ChIP-Seq_VCAP_Human	1.10098940
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09060389
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08684607
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08582338
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08267866
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.06225851
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05739300
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05095354
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04754201
90	JUN_21703547_ChIP-Seq_K562_Human	1.03789829
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01416381
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99564890
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99347188
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96907067
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95288102
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.94548253
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.92105266
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.91874057
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.91097063
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.90446666

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.99998285
2	MP0008877_abnormal_DNA_methylation	2.77983340
3	MP0003195_calcinosis	2.74135546
4	MP0005551_abnormal_eye_electrophysiolog	2.53107222
5	MP0001968_abnormal_touch/_nociception	2.43335284
6	MP0000569_abnormal_digit_pigmentation	2.43175379
7	MP0002837_dystrophic_cardiac_calcinosis	2.39258515
8	MP0002102_abnormal_ear_morphology	2.35215235
9	MP0003646_muscle_fatigue	2.34745160
10	MP0003787_abnormal_imprinting	2.31398616
11	MP0002736_abnormal_nociception_after	2.26339300
12	MP0002638_abnormal_pupillary_reflex	2.25803885
13	MP0006276_abnormal_autonomic_nervous	2.18444073
14	MP0009046_muscle_twitch	2.08526557
15	MP0002653_abnormal_ependyma_morphology	2.07867267
16	MP0003136_yellow_coat_color	2.04548368
17	MP0003880_abnormal_central_pattern	1.86688508
18	MP0005646_abnormal_pituitary_gland	1.85646223
19	MP0009745_abnormal_behavioral_response	1.84878539
20	MP0004142_abnormal_muscle_tone	1.82622603
21	MP0005253_abnormal_eye_physiology	1.80024947
22	MP0006072_abnormal_retinal_apoptosis	1.79580491
23	MP0002876_abnormal_thyroid_physiology	1.78159342
24	MP0004043_abnormal_pH_regulation	1.71403956
25	MP0001501_abnormal_sleep_pattern	1.68398195
26	MP0002272_abnormal_nervous_system	1.64215074
27	MP0002938_white_spotting	1.60630897
28	MP0000372_irregular_coat_pigmentation	1.60251828
29	MP0002138_abnormal_hepatobiliary_system	1.59888343
30	MP0005645_abnormal_hypothalamus_physiol	1.56374087
31	MP0008875_abnormal_xenobiotic_pharmacok	1.53263737
32	MP0010386_abnormal_urinary_bladder	1.53128520
33	MP0001486_abnormal_startle_reflex	1.51913738
34	MP0008872_abnormal_physiological_respon	1.51346536
35	MP0000427_abnormal_hair_cycle	1.50225700
36	MP0004133_heterotaxia	1.47289023
37	MP0004147_increased_porphyrin_level	1.39848886
38	MP0003011_delayed_dark_adaptation	1.38885872
39	MP0000631_abnormal_neuroendocrine_gland	1.37528071
40	MP0001986_abnormal_taste_sensitivity	1.35863634
41	MP0001485_abnormal_pinna_reflex	1.35729053
42	MP0002735_abnormal_chemical_nociception	1.34740231
43	MP0002572_abnormal_emotion/affect_behav	1.33022264
44	MP0005084_abnormal_gallbladder_morpholo	1.31695363
45	MP0001970_abnormal_pain_threshold	1.30119814
46	MP0004885_abnormal_endolymph	1.30012415
47	MP0001984_abnormal_olfaction	1.29248858
48	MP0002064_seizures	1.28827598
49	MP0002234_abnormal_pharynx_morphology	1.25438311
50	MP0002557_abnormal_social/conspecific_i	1.25070282
51	MP0002160_abnormal_reproductive_system	1.22039623
52	MP0002928_abnormal_bile_duct	1.21948928
53	MP0002733_abnormal_thermal_nociception	1.18826732
54	MP0004742_abnormal_vestibular_system	1.16544756
55	MP0001529_abnormal_vocalization	1.15245620
56	MP0005174_abnormal_tail_pigmentation	1.15135000
57	MP0003635_abnormal_synaptic_transmissio	1.13737554
58	MP0005389_reproductive_system_phenotype	1.13676913
59	MP0005379_endocrine/exocrine_gland_phen	1.11052711
60	MP0003252_abnormal_bile_duct	1.09365889
61	MP0005167_abnormal_blood-brain_barrier	1.09302541
62	MP0000383_abnormal_hair_follicle	1.08460105
63	MP0004145_abnormal_muscle_electrophysio	1.07671081
64	MP0002067_abnormal_sensory_capabilities	1.07661272
65	MP0004924_abnormal_behavior	1.07503207
66	MP0005386_behavior/neurological_phenoty	1.07503207
67	MP0008789_abnormal_olfactory_epithelium	1.06971287
68	MP0005085_abnormal_gallbladder_physiolo	1.05320659
69	MP0005410_abnormal_fertilization	1.05308018
70	MP0003121_genomic_imprinting	1.02073869
71	MP0005195_abnormal_posterior_eye	1.01777424
72	MP0002163_abnormal_gland_morphology	1.01754882
73	MP0002734_abnormal_mechanical_nocicepti	1.01059845
74	MP0005423_abnormal_somatic_nervous	1.00859676
75	MP0002063_abnormal_learning/memory/cond	0.99417393
76	MP0001919_abnormal_reproductive_system	0.97538311
77	MP0002095_abnormal_skin_pigmentation	0.97134098
78	MP0000778_abnormal_nervous_system	0.95438479
79	MP0003718_maternal_effect	0.94593418
80	MP0008058_abnormal_DNA_repair	0.93756724
81	MP0000230_abnormal_systemic_arterial	0.92157055
82	MP0002752_abnormal_somatic_nervous	0.91417702
83	MP0001963_abnormal_hearing_physiology	0.88781515
84	MP0002751_abnormal_autonomic_nervous	0.88769401
85	MP0001905_abnormal_dopamine_level	0.87437732
86	MP0005377_hearing/vestibular/ear_phenot	0.86948747
87	MP0003878_abnormal_ear_physiology	0.86948747
88	MP0000647_abnormal_sebaceous_gland	0.84642697
89	MP0005187_abnormal_penis_morphology	0.83380663
90	MP0001440_abnormal_grooming_behavior	0.83251038
91	MP0002229_neurodegeneration	0.83155885
92	MP0000026_abnormal_inner_ear	0.82480212
93	MP0003122_maternal_imprinting	0.80172215
94	MP0003698_abnormal_male_reproductive	0.79587969
95	MP0008995_early_reproductive_senescence	0.79400111
96	MP0001324_abnormal_eye_pigmentation	0.78838816
97	MP0003890_abnormal_embryonic-extraembry	0.78645438
98	MP0002184_abnormal_innervation	0.77723528
99	MP0005394_taste/olfaction_phenotype	0.75228822
100	MP0005499_abnormal_olfactory_system	0.75228822

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.38538951
2	Pancreatic fibrosis (HP:0100732)	4.29508066
3	Abnormality of midbrain morphology (HP:0002418)	4.08056479
4	Molar tooth sign on MRI (HP:0002419)	4.08056479
5	Congenital stationary night blindness (HP:0007642)	4.05899955
6	True hermaphroditism (HP:0010459)	4.02837976
7	Nephronophthisis (HP:0000090)	3.56469537
8	Attenuation of retinal blood vessels (HP:0007843)	3.23697059
9	Chronic hepatic failure (HP:0100626)	3.19598197
10	Medial flaring of the eyebrow (HP:0010747)	3.18389090
11	Abnormality of the renal medulla (HP:0100957)	3.12197517
12	Abolished electroretinogram (ERG) (HP:0000550)	3.09799257
13	Hyperventilation (HP:0002883)	3.06005045
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.02310514
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.93115526
16	Type II lissencephaly (HP:0007260)	2.92657686
17	Abnormality of the renal cortex (HP:0011035)	2.92235895
18	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.75233004
19	Absent/shortened dynein arms (HP:0200106)	2.75233004
20	Cystic liver disease (HP:0006706)	2.70849711
21	Decreased central vision (HP:0007663)	2.70634922
22	Gait imbalance (HP:0002141)	2.68566213
23	Abnormality of alanine metabolism (HP:0010916)	2.61987198
24	Hyperalaninemia (HP:0003348)	2.61987198
25	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.61987198
26	Sclerocornea (HP:0000647)	2.61904474
27	Congenital primary aphakia (HP:0007707)	2.59211782
28	Pendular nystagmus (HP:0012043)	2.51252406
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46943018
30	Tubular atrophy (HP:0000092)	2.45866280
31	Progressive cerebellar ataxia (HP:0002073)	2.44710534
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.44164549
33	Gaze-evoked nystagmus (HP:0000640)	2.43811046
34	Nephrogenic diabetes insipidus (HP:0009806)	2.42072457
35	Inability to walk (HP:0002540)	2.34906145
36	Acute necrotizing encephalopathy (HP:0006965)	2.34544401
37	Genetic anticipation (HP:0003743)	2.34302855
38	Increased corneal curvature (HP:0100692)	2.31776425
39	Keratoconus (HP:0000563)	2.31776425
40	Cerebellar dysplasia (HP:0007033)	2.29463096
41	Lissencephaly (HP:0001339)	2.28763926
42	Increased CSF lactate (HP:0002490)	2.27656815
43	Broad-based gait (HP:0002136)	2.26786882
44	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.26022793
45	Hypoplasia of the fovea (HP:0007750)	2.26022793
46	Anencephaly (HP:0002323)	2.25303628
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23543595
48	Optic nerve hypoplasia (HP:0000609)	2.22067294
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21839001
50	Febrile seizures (HP:0002373)	2.20487870
51	Congenital sensorineural hearing impairment (HP:0008527)	2.20041282
52	Abnormal drinking behavior (HP:0030082)	2.19977035
53	Polydipsia (HP:0001959)	2.19977035
54	Abnormal respiratory motile cilium morphology (HP:0005938)	2.19135177
55	Abnormal respiratory epithelium morphology (HP:0012253)	2.19135177
56	Mitochondrial inheritance (HP:0001427)	2.19025586
57	Abnormal ciliary motility (HP:0012262)	2.17566249
58	Decreased circulating renin level (HP:0003351)	2.16639557
59	Male pseudohermaphroditism (HP:0000037)	2.14938512
60	Acute encephalopathy (HP:0006846)	2.14091213
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.13330150
62	Genital tract atresia (HP:0001827)	2.11811975
63	Congenital hepatic fibrosis (HP:0002612)	2.06409335
64	Progressive inability to walk (HP:0002505)	2.06212585
65	Vaginal atresia (HP:0000148)	2.05867050
66	Progressive macrocephaly (HP:0004481)	2.00530655
67	Constricted visual fields (HP:0001133)	1.98966419
68	Postaxial foot polydactyly (HP:0001830)	1.97483471
69	Bile duct proliferation (HP:0001408)	1.96705107
70	Abnormal biliary tract physiology (HP:0012439)	1.96705107
71	Abnormal mitochondria in muscle tissue (HP:0008316)	1.96011355
72	Fair hair (HP:0002286)	1.95654700
73	Renal cortical cysts (HP:0000803)	1.95177783
74	Furrowed tongue (HP:0000221)	1.94600180
75	Protruding tongue (HP:0010808)	1.93760264
76	Hepatic necrosis (HP:0002605)	1.93561192
77	Hepatocellular necrosis (HP:0001404)	1.93281955
78	Abnormality of the fovea (HP:0000493)	1.92262670
79	Pachygyria (HP:0001302)	1.92015437
80	Abnormality of the labia minora (HP:0012880)	1.91577026
81	Large for gestational age (HP:0001520)	1.87845615
82	Absent speech (HP:0001344)	1.86753339
83	Retinitis pigmentosa (HP:0000510)	1.84012152
84	Abnormality of macular pigmentation (HP:0008002)	1.83663284
85	Hemiparesis (HP:0001269)	1.82545016
86	Preaxial hand polydactyly (HP:0001177)	1.82510700
87	Polyuria (HP:0000103)	1.82193046
88	Retinal dysplasia (HP:0007973)	1.81369302
89	Hyperglycinuria (HP:0003108)	1.79090360
90	Intestinal atresia (HP:0011100)	1.78579557
91	Concave nail (HP:0001598)	1.78561839
92	Poor coordination (HP:0002370)	1.78401716
93	Postaxial hand polydactyly (HP:0001162)	1.78120092
94	Optic disc pallor (HP:0000543)	1.77385340
95	Occipital encephalocele (HP:0002085)	1.77047540
96	Dialeptic seizures (HP:0011146)	1.76813153
97	Hypothermia (HP:0002045)	1.76466509
98	Agitation (HP:0000713)	1.75810431
99	Clumsiness (HP:0002312)	1.75342459
100	Focal seizures (HP:0007359)	1.73519219

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.47227439
2	BMPR1B	2.97845237
3	WNK3	2.83553489
4	ADRBK2	2.75405694
5	GRK1	2.60892828
6	MAP4K2	2.58522914
7	ZAK	2.39768986
8	PINK1	2.34258035
9	ACVR1B	2.34200951
10	NUAK1	2.20212341
11	MAPK13	2.06618872
12	TAOK3	2.05535823
13	STK16	1.94442765
14	INSRR	1.87878392
15	WNK4	1.86068632
16	CASK	1.73458686
17	MAP3K4	1.67441844
18	TRIM28	1.54857221
19	OXSR1	1.44659153
20	STK38L	1.34289383
21	TXK	1.31735189
22	PAK3	1.30976612
23	TLK1	1.30868803
24	NTRK3	1.26797222
25	DYRK2	1.26177195
26	MKNK2	1.24731991
27	BCR	1.22664531
28	STK39	1.16732787
29	DAPK2	1.13778654
30	TNIK	1.12804450
31	PRKCG	1.06904639
32	ADRBK1	1.06741973
33	MARK1	1.04147975
34	MAP2K7	1.01016910
35	BCKDK	1.00824594
36	CAMKK2	0.99394625
37	TGFBR1	0.98782136
38	PIK3CA	0.98522172
39	PRKCE	0.97653070
40	CDK19	0.97528234
41	BRSK2	0.97201830
42	CSNK1A1L	0.93181080
43	CSNK1G2	0.92343493
44	CSNK1G3	0.91275325
45	PTK2B	0.89844573
46	PLK2	0.83465000
47	CSNK1G1	0.82124070
48	EIF2AK3	0.80916958
49	MST4	0.72884670
50	ERBB3	0.69174389
51	AKT3	0.65840484
52	STK3	0.65111070
53	VRK1	0.63355154
54	TEC	0.61836577
55	SIK2	0.61306502
56	PHKG1	0.60995451
57	PHKG2	0.60995451
58	CAMK2A	0.59162757
59	EPHA4	0.58293741
60	PIK3CG	0.57098208
61	PRKACA	0.52698478
62	MKNK1	0.52456675
63	KIT	0.51127286
64	CAMK1	0.50703637
65	STK11	0.50137463
66	IKBKB	0.49722756
67	CSNK1A1	0.49212537
68	DYRK1A	0.47430705
69	MUSK	0.46801851
70	PRKCH	0.45094233
71	VRK2	0.45072371
72	FER	0.44728104
73	DYRK3	0.43918613
74	PKN1	0.43458935
75	TIE1	0.43179161
76	OBSCN	0.41371738
77	PLK4	0.41303705
78	PRKCZ	0.41181105
79	PRKAA2	0.41043791
80	ERBB2	0.40942450
81	TNK2	0.40347260
82	RPS6KA5	0.39913266
83	PDK2	0.38848405
84	PRKCA	0.38821967
85	PRKCQ	0.38016004
86	CSNK1D	0.37332203
87	PRKAA1	0.37219202
88	FLT3	0.37094912
89	HIPK2	0.36931450
90	GRK5	0.36686963
91	WEE1	0.36371033
92	TAF1	0.35411119
93	PLK3	0.34752907
94	PRKCI	0.33527052
95	NTRK2	0.33053734
96	PRKG1	0.33029407
97	PLK1	0.32958591
98	ITK	0.30897710
99	GRK7	0.29739833
100	ATR	0.29504495

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.98114509
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49428394
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46522215
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43977241
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43737871
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31539135
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.25630987
8	Nicotine addiction_Homo sapiens_hsa05033	2.25095279
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10288793
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.07037723
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.06493984
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00518004
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97317309
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96251446
15	Homologous recombination_Homo sapiens_hsa03440	1.84072908
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.83860494
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.71654950
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.67137910
19	Protein export_Homo sapiens_hsa03060	1.64436807
20	Propanoate metabolism_Homo sapiens_hsa00640	1.59331106
21	Parkinsons disease_Homo sapiens_hsa05012	1.56710200
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.56394336
23	Taste transduction_Homo sapiens_hsa04742	1.55628927
24	Olfactory transduction_Homo sapiens_hsa04740	1.54917546
25	Caffeine metabolism_Homo sapiens_hsa00232	1.53781642
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48379677
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.47222355
28	RNA polymerase_Homo sapiens_hsa03020	1.46563300
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44644405
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43290218
31	Basal transcription factors_Homo sapiens_hsa03022	1.39848118
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.37052559
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.36362433
34	Morphine addiction_Homo sapiens_hsa05032	1.33590318
35	ABC transporters_Homo sapiens_hsa02010	1.29190173
36	Retinol metabolism_Homo sapiens_hsa00830	1.28975014
37	Peroxisome_Homo sapiens_hsa04146	1.26419802
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25505756
39	Huntingtons disease_Homo sapiens_hsa05016	1.20329937
40	beta-Alanine metabolism_Homo sapiens_hsa00410	1.15773885
41	GABAergic synapse_Homo sapiens_hsa04727	1.14186234
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.12431446
43	Serotonergic synapse_Homo sapiens_hsa04726	1.08286170
44	One carbon pool by folate_Homo sapiens_hsa00670	1.07406372
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07139652
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.03978723
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03762035
48	RNA degradation_Homo sapiens_hsa03018	1.02709768
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.02385396
50	Circadian entrainment_Homo sapiens_hsa04713	1.01608227
51	Alzheimers disease_Homo sapiens_hsa05010	1.00799122
52	Glutamatergic synapse_Homo sapiens_hsa04724	0.97577516
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96357846
54	Insulin secretion_Homo sapiens_hsa04911	0.94683558
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91721417
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85987867
57	Histidine metabolism_Homo sapiens_hsa00340	0.84866507
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.84061977
59	Regulation of autophagy_Homo sapiens_hsa04140	0.82716160
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79127903
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77880771
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76233090
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76023075
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75438340
65	Asthma_Homo sapiens_hsa05310	0.72727831
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.71625145
67	Salivary secretion_Homo sapiens_hsa04970	0.71569169
68	Metabolic pathways_Homo sapiens_hsa01100	0.70642007
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67520904
70	Sulfur metabolism_Homo sapiens_hsa00920	0.66575709
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66078147
72	Purine metabolism_Homo sapiens_hsa00230	0.65562496
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64722137
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64316535
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63871769
76	Fatty acid degradation_Homo sapiens_hsa00071	0.58560631
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.55561033
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.55081588
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49960253
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.49555993
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49363308
82	Proteasome_Homo sapiens_hsa03050	0.46239125
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45769492
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44593234
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.43479407
86	Circadian rhythm_Homo sapiens_hsa04710	0.43400205
87	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42058336
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38870360
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.38046406
90	Cocaine addiction_Homo sapiens_hsa05030	0.37267636
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37068557
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36388318
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36080092
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35766231
95	Long-term depression_Homo sapiens_hsa04730	0.34972907
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.33376141
97	Glutathione metabolism_Homo sapiens_hsa00480	0.33360404
98	Fatty acid elongation_Homo sapiens_hsa00062	0.31120790
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.30493348
100	Amphetamine addiction_Homo sapiens_hsa05031	0.29726066

GYG2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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