GYPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemoglobin metabolic process (GO:0020027)9.79140564
2response to methylmercury (GO:0051597)8.67112449
3erythrocyte development (GO:0048821)8.21332172
4response to insecticide (GO:0017085)7.24583894
5tetrapyrrole metabolic process (GO:0033013)7.02005613
6response to lead ion (GO:0010288)6.97452814
7pigment biosynthetic process (GO:0046148)6.39033651
8erythrocyte differentiation (GO:0030218)5.70885596
9one-carbon compound transport (GO:0019755)5.67173423
10myeloid cell development (GO:0061515)5.24855577
11pigment metabolic process (GO:0042440)5.23460400
12negative regulation of erythrocyte differentiation (GO:0045647)5.01281927
13antibacterial humoral response (GO:0019731)4.76765286
14very-low-density lipoprotein particle assembly (GO:0034379)4.74809960
15response to arsenic-containing substance (GO:0046685)4.71845890
16innate immune response in mucosa (GO:0002227)4.54634399
17nucleosome assembly (GO:0006334)4.43798148
18mitotic sister chromatid segregation (GO:0000070)4.43090167
19antimicrobial humoral response (GO:0019730)4.42428154
20bicarbonate transport (GO:0015701)4.40039589
21DNA topological change (GO:0006265)4.35975473
22glycine transport (GO:0015816)4.33033765
23regulation of RNA export from nucleus (GO:0046831)4.24329712
24gas transport (GO:0015669)4.13089084
25DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.11175944
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.09611964
27microtubule depolymerization (GO:0007019)4.06828734
28sister chromatid segregation (GO:0000819)4.03200265
29regulation of DNA endoreduplication (GO:0032875)3.99506412
30nucleosome organization (GO:0034728)3.82480820
31protein-DNA complex assembly (GO:0065004)3.78637047
32negative regulation of viral entry into host cell (GO:0046597)3.73634313
33DNA damage response, signal transduction resulting in transcription (GO:0042772)3.72929452
34mitotic chromosome condensation (GO:0007076)3.65481207
35nuclear pore complex assembly (GO:0051292)3.65188494
36DNA replication-dependent nucleosome assembly (GO:0006335)3.64175444
37DNA replication-dependent nucleosome organization (GO:0034723)3.64175444
38positive regulation of megakaryocyte differentiation (GO:0045654)3.63205880
39kinetochore organization (GO:0051383)3.62809362
40positive regulation of granulocyte differentiation (GO:0030854)3.62232060
41protein localization to chromosome, centromeric region (GO:0071459)3.61185444
42heme transport (GO:0015886)3.60084421
43mucosal immune response (GO:0002385)3.55456199
44iron ion import (GO:0097286)3.53184794
45cofactor biosynthetic process (GO:0051188)3.49716909
46attachment of spindle microtubules to kinetochore (GO:0008608)3.45292266
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.42940183
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.42940183
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.42940183
50regulation of nucleobase-containing compound transport (GO:0032239)3.41362103
51embryonic hemopoiesis (GO:0035162)3.41106169
52actin filament capping (GO:0051693)3.38093500
53DNA replication checkpoint (GO:0000076)3.37708448
54protein-DNA complex subunit organization (GO:0071824)3.37275268
55positive regulation of chromosome segregation (GO:0051984)3.36995949
56chromatin assembly (GO:0031497)3.36778368
57positive regulation of erythrocyte differentiation (GO:0045648)3.36631890
58plasma lipoprotein particle assembly (GO:0034377)3.36534442
59organ or tissue specific immune response (GO:0002251)3.35454985
60platelet formation (GO:0030220)3.32935410
61DNA replication initiation (GO:0006270)3.29895416
62protein-cofactor linkage (GO:0018065)3.27589078
63protein localization to kinetochore (GO:0034501)3.23960451
64nuclear pore organization (GO:0006999)3.21885013
65meiotic chromosome segregation (GO:0045132)3.20638381
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.18466852
67granulocyte differentiation (GO:0030851)3.18354917
68N-terminal protein amino acid acetylation (GO:0006474)3.17621940
69regulation of cytokine secretion involved in immune response (GO:0002739)3.11542621
70L-alpha-amino acid transmembrane transport (GO:1902475)3.04676724
71positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.02614652
72chromatin assembly or disassembly (GO:0006333)3.01557917
73protoporphyrinogen IX metabolic process (GO:0046501)21.4627858
74iron ion homeostasis (GO:0055072)2.98931448
75hematopoietic stem cell differentiation (GO:0060218)2.97935598
76regulation of histone H3-K4 methylation (GO:0051569)2.92911131
77DNA strand elongation involved in DNA replication (GO:0006271)2.91301453
78kinetochore assembly (GO:0051382)2.90468892
79regulation of histone H3-K9 methylation (GO:0051570)2.89610945
80protein-lipid complex assembly (GO:0065005)2.87314460
81DNA unwinding involved in DNA replication (GO:0006268)2.84783216
82cellular response to dexamethasone stimulus (GO:0071549)2.84596637
83definitive hemopoiesis (GO:0060216)2.84059402
84DNA strand elongation (GO:0022616)2.82454716
85telomere maintenance via semi-conservative replication (GO:0032201)2.81782458
86hemopoiesis (GO:0030097)2.81617834
87regulation of exit from mitosis (GO:0007096)2.79397697
88regulation of viral entry into host cell (GO:0046596)2.79005563
89regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77049154
90protein autoprocessing (GO:0016540)2.75150180
91regulation of erythrocyte differentiation (GO:0045646)2.72542147
92response to dexamethasone (GO:0071548)2.68040023
93mitotic nuclear envelope disassembly (GO:0007077)2.67947197
94CENP-A containing nucleosome assembly (GO:0034080)2.65176089
95cellular response to arsenic-containing substance (GO:0071243)2.64594789
96pore complex assembly (GO:0046931)2.61731431
97nuclear envelope disassembly (GO:0051081)2.61689581
98membrane disassembly (GO:0030397)2.61689581
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60874326
100killing of cells of other organism (GO:0031640)2.60783536
101disruption of cells of other organism (GO:0044364)2.60783536
102negative regulation of actin filament depolymerization (GO:0030835)2.60774648
103hydrogen peroxide catabolic process (GO:0042744)2.56651228
104microtubule polymerization or depolymerization (GO:0031109)2.55471094
105defense response to fungus (GO:0050832)2.55375250
106cysteine metabolic process (GO:0006534)2.55252245
107regulation of centriole replication (GO:0046599)2.54821332
108response to folic acid (GO:0051593)2.54805192
109DNA replication-independent nucleosome organization (GO:0034724)2.51980802
110DNA replication-independent nucleosome assembly (GO:0006336)2.51980802
1113-UTR-mediated mRNA stabilization (GO:0070935)2.51646026
112regulation of centrosome cycle (GO:0046605)2.50920815
113negative regulation of histone methylation (GO:0031061)2.50083242
114protein localization to chromosome (GO:0034502)2.48186386
115chromosome segregation (GO:0007059)2.47621835
116megakaryocyte development (GO:0035855)2.45624689
117chromatin remodeling at centromere (GO:0031055)2.44608087
118negative regulation of protein acetylation (GO:1901984)2.44274278
119response to iron ion (GO:0010039)2.43023030
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42352932
121monoubiquitinated protein deubiquitination (GO:0035520)2.41706447
122regulation of translational fidelity (GO:0006450)2.40825905
123potassium ion export (GO:0071435)2.40676746
124mitotic metaphase plate congression (GO:0007080)2.40471757
125iron coordination entity transport (GO:1901678)2.39126412
126synapsis (GO:0007129)2.34103839
127mitotic G2/M transition checkpoint (GO:0044818)2.32921474
128proline biosynthetic process (GO:0006561)2.32862408
129deoxyribose phosphate biosynthetic process (GO:0046385)2.32272924
1302-deoxyribonucleotide biosynthetic process (GO:0009265)2.32272924
131protoporphyrinogen IX biosynthetic process (GO:0006782)19.9877755
132porphyrin-containing compound biosynthetic process (GO:0006779)13.9655247
133heme biosynthetic process (GO:0006783)13.8309367
134oxygen transport (GO:0015671)13.1529371
135tetrapyrrole biosynthetic process (GO:0033014)12.4795355
136porphyrin-containing compound metabolic process (GO:0006778)10.9229193
137heme metabolic process (GO:0042168)10.7078056
138erythrocyte maturation (GO:0043249)10.2670282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48298874
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.19040332
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse6.09386553
4GATA1_22025678_ChIP-Seq_K562_Human5.34153543
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.33380506
6GATA1_19941826_ChIP-Seq_K562_Human4.38255682
7* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse4.19773789
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.97771155
9* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.69680295
10* GATA1_19941827_ChIP-Seq_MEL_Mouse3.60982417
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30271840
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25755362
13SCL_19346495_ChIP-Seq_HPC-7_Human2.93693402
14GATA1_22383799_ChIP-Seq_G1ME_Mouse2.55752217
15GATA2_19941826_ChIP-Seq_K562_Human2.43431229
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.05580682
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97116575
18AR_21909140_ChIP-Seq_LNCAP_Human1.80834521
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75544124
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67424752
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65535225
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57833487
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.56209734
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53794706
25ZNF263_19887448_ChIP-Seq_K562_Human1.53785900
26SOX2_16153702_ChIP-ChIP_HESCs_Human1.52583324
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51731548
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51313749
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42415896
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41275959
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.40742729
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38029016
33MYC_22102868_ChIP-Seq_BL_Human1.37845516
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36183541
35VDR_23849224_ChIP-Seq_CD4+_Human1.34491163
36GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34141019
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33525077
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33490025
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31310387
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30731741
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.30493447
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29666632
43VDR_21846776_ChIP-Seq_THP-1_Human1.27341984
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27144201
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24003459
46* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23550564
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23107333
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21430899
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21252055
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20756734
51CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.18276549
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18039576
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17888502
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15861717
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13752184
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13742402
57SPI1_23127762_ChIP-Seq_K562_Human1.13714094
58EST1_17652178_ChIP-ChIP_JURKAT_Human1.13222341
59NCOR1_26117541_ChIP-Seq_K562_Human1.10299211
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09641932
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08094711
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06994935
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06008320
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03161507
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02993215
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02863175
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01580972
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01336764
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00786918
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00491844
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99794488
72E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97645884
73ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97336618
74ETS1_20019798_ChIP-Seq_JURKAT_Human0.96965113
75MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95168618
76TTF2_22483619_ChIP-Seq_HELA_Human0.95117189
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94692805
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94115051
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93888843
80XRN2_22483619_ChIP-Seq_HELA_Human0.93467843
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93388279
82SALL4_22934838_ChIP-ChIP_CD34+_Human0.90730146
83DCP1A_22483619_ChIP-Seq_HELA_Human0.90649166
84RUNX1_22412390_ChIP-Seq_EML_Mouse0.89916759
85WT1_19549856_ChIP-ChIP_CCG9911_Human0.89685780
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87934872
87MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87316200
88MAF_26560356_Chip-Seq_TH1_Human0.86881495
89ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86866991
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86045872
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85872967
92GABP_19822575_ChIP-Seq_HepG2_Human0.85303908
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85116683
94MYB_26560356_Chip-Seq_TH1_Human0.84943987
95KDM5A_27292631_Chip-Seq_BREAST_Human0.84651443
96FOXP3_21729870_ChIP-Seq_TREG_Human0.83973176
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83936447
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.83310869
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.82947932
100SPI1_23547873_ChIP-Seq_NB4_Human0.82672419
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82614241
102TFEB_21752829_ChIP-Seq_HELA_Human0.81450003
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81426016
104CHD1_26751641_Chip-Seq_LNCaP_Human0.80424200
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79758194
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79319626
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79306571
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79261625
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78653394
110GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76736971
111TP53_22573176_ChIP-Seq_HFKS_Human0.76460126
112UTX_26944678_Chip-Seq_JUKART_Human0.76070040
113ELK1_19687146_ChIP-ChIP_HELA_Human0.74583264
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73852091
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73699162
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.72473961
117TCF7_22412390_ChIP-Seq_EML_Mouse0.72366138
118EGR1_19374776_ChIP-ChIP_THP-1_Human0.71250088
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71044701
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.70946541
121CIITA_25753668_ChIP-Seq_RAJI_Human0.69562073
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69561813
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69246241
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.69065905
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.68276860
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.68052632
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.67776851
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67512819
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67190079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.37076653
2MP0005083_abnormal_biliary_tract3.28426456
3MP0008995_early_reproductive_senescence2.81922350
4MP0010094_abnormal_chromosome_stability2.54019098
5MP0003077_abnormal_cell_cycle2.28760112
6MP0001545_abnormal_hematopoietic_system2.19683360
7MP0005397_hematopoietic_system_phenotyp2.19683360
8MP0005636_abnormal_mineral_homeostasis2.03900250
9MP0003656_abnormal_erythrocyte_physiolo12.1451602
10MP0004147_increased_porphyrin_level11.9360732
11MP0003693_abnormal_embryo_hatching1.93760948
12MP0009278_abnormal_bone_marrow1.86595812
13MP0008057_abnormal_DNA_replication1.72599963
14MP0009697_abnormal_copulation1.66555839
15MP0010307_abnormal_tumor_latency1.61248755
16MP0004957_abnormal_blastocyst_morpholog1.58825332
17MP0003186_abnormal_redox_activity1.34020388
18MP0000490_abnormal_crypts_of1.31134058
19MP0006036_abnormal_mitochondrial_physio1.29132973
20MP0002398_abnormal_bone_marrow1.28649379
21MP0002396_abnormal_hematopoietic_system1.22615503
22MP0002736_abnormal_nociception_after1.22243567
23MP0000350_abnormal_cell_proliferation1.19771772
24MP0001661_extended_life_span1.18963529
25MP0008872_abnormal_physiological_respon1.17789434
26MP0005501_abnormal_skin_physiology1.17622726
27MP0003890_abnormal_embryonic-extraembry1.14408148
28MP0008058_abnormal_DNA_repair1.12784370
29MP0006054_spinal_hemorrhage1.09851935
30MP0002722_abnormal_immune_system1.09726854
31MP0002139_abnormal_hepatobiliary_system1.08591944
32MP0000689_abnormal_spleen_morphology1.07909573
33MP0005464_abnormal_platelet_physiology1.07068682
34MP0004145_abnormal_muscle_electrophysio1.05396892
35MP0002132_abnormal_respiratory_system1.05100698
36MP0008775_abnormal_heart_ventricle1.03660880
37MP0003806_abnormal_nucleotide_metabolis1.01759448
38MP0000313_abnormal_cell_death0.97759451
39MP0003878_abnormal_ear_physiology0.97745053
40MP0005377_hearing/vestibular/ear_phenot0.97745053
41MP0005451_abnormal_body_composition0.95969829
42MP0009931_abnormal_skin_appearance0.95800131
43MP0006035_abnormal_mitochondrial_morpho0.94940881
44MP0002019_abnormal_tumor_incidence0.94822111
45MP0008770_decreased_survivor_rate0.94544300
46MP0001529_abnormal_vocalization0.94351516
47MP0008260_abnormal_autophagy0.93436530
48* MP0002429_abnormal_blood_cell0.91300049
49MP0000685_abnormal_immune_system0.89153019
50MP0000749_muscle_degeneration0.87888070
51MP0002877_abnormal_melanocyte_morpholog0.85708154
52MP0005171_absent_coat_pigmentation0.84580486
53MP0000372_irregular_coat_pigmentation0.84533244
54MP0004808_abnormal_hematopoietic_stem0.83257377
55MP0002735_abnormal_chemical_nociception0.83021878
56MP0001730_embryonic_growth_arrest0.80775776
57MP0005076_abnormal_cell_differentiation0.78542175
58MP0000015_abnormal_ear_pigmentation0.77270796
59MP0009764_decreased_sensitivity_to0.76083937
60MP0008877_abnormal_DNA_methylation0.75441154
61MP0009765_abnormal_xenobiotic_induced0.75273044
62MP0002009_preneoplasia0.74904613
63MP0002080_prenatal_lethality0.74606120
64MP0002086_abnormal_extraembryonic_tissu0.70338545
65MP0008932_abnormal_embryonic_tissue0.68944722
66MP0001929_abnormal_gametogenesis0.68375943
67MP0003191_abnormal_cellular_cholesterol0.68131803
68MP0000609_abnormal_liver_physiology0.67562977
69MP0001697_abnormal_embryo_size0.65433214
70MP0000703_abnormal_thymus_morphology0.65152971
71MP0003718_maternal_effect0.64760364
72MP0005085_abnormal_gallbladder_physiolo0.64337567
73MP0002210_abnormal_sex_determination0.62362264
74MP0009333_abnormal_splenocyte_physiolog0.59888240
75MP0004215_abnormal_myocardial_fiber0.59390153
76MP0004885_abnormal_endolymph0.59232308
77MP0001968_abnormal_touch/_nociception0.59167030
78MP0003172_abnormal_lysosome_physiology0.58949868
79MP0003300_gastrointestinal_ulcer0.57732625
80MP0000598_abnormal_liver_morphology0.56297719
81MP0010771_integument_phenotype0.56182543
82MP0003221_abnormal_cardiomyocyte_apopto0.56074458
83MP0005621_abnormal_cell_physiology0.54486720
84MP0004185_abnormal_adipocyte_glucose0.54351602
85MP0008007_abnormal_cellular_replicative0.53319956
86MP0005384_cellular_phenotype0.52964959
87MP0009053_abnormal_anal_canal0.52908260
88MP0003698_abnormal_male_reproductive0.52841083
89MP0009763_increased_sensitivity_to0.52482173
90MP0001672_abnormal_embryogenesis/_devel0.52419410
91MP0005380_embryogenesis_phenotype0.52419410
92MP0004197_abnormal_fetal_growth/weight/0.50045456
93MP0003984_embryonic_growth_retardation0.49478443
94MP0005671_abnormal_response_to0.49362248
95MP0010352_gastrointestinal_tract_polyps0.48695458
96MP0005220_abnormal_exocrine_pancreas0.48242211
97MP0000358_abnormal_cell_content/0.47151553
98MP0002088_abnormal_embryonic_growth/wei0.47079201
99MP0005075_abnormal_melanosome_morpholog0.47039288
100MP0002095_abnormal_skin_pigmentation0.46990561
101MP0004130_abnormal_muscle_cell0.46540870
102MP0003045_fibrosis0.46497918
103MP0002138_abnormal_hepatobiliary_system0.45023762
104MP0000653_abnormal_sex_gland0.44986367
105MP0009643_abnormal_urine_homeostasis0.44770658
106MP0001764_abnormal_homeostasis0.44748197
107MP0004264_abnormal_extraembryonic_tissu0.44350136
108MP0009672_abnormal_birth_weight0.44197613
109MP0001191_abnormal_skin_condition0.43811899
110MP0000716_abnormal_immune_system0.43704878
111MP0001243_abnormal_dermal_layer0.43206085
112MP0005187_abnormal_penis_morphology0.43105043
113MP0003787_abnormal_imprinting0.42713278
114MP0001145_abnormal_male_reproductive0.42525584
115MP0003699_abnormal_female_reproductive0.41915522
116MP0001784_abnormal_fluid_regulation0.41559940
117MP0002166_altered_tumor_susceptibility0.40999260
118MP0000747_muscle_weakness0.40486067
119MP0005319_abnormal_enzyme/_coenzyme0.39924032
120MP0002083_premature_death0.39134255
121MP0000858_altered_metastatic_potential0.38930008
122MP0002405_respiratory_system_inflammati0.38428925
123MP0005584_abnormal_enzyme/coenzyme_acti0.38416330
124MP0003786_premature_aging0.37850926
125MP0008789_abnormal_olfactory_epithelium0.36978759
126MP0001915_intracranial_hemorrhage0.36492865
127MP0002332_abnormal_exercise_endurance0.36089421
128MP0003303_peritoneal_inflammation0.36033772
129MP0005360_urolithiasis0.35975716
130MP0003567_abnormal_fetal_cardiomyocyte0.35076477
131MP0009703_decreased_birth_body0.35038595
132MP0005499_abnormal_olfactory_system0.34421634
133MP0005394_taste/olfaction_phenotype0.34421634
134MP0000266_abnormal_heart_morphology0.34075554

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)9.27768131
2Abnormal hemoglobin (HP:0011902)8.13169731
3Reticulocytosis (HP:0001923)8.02191129
4Cholelithiasis (HP:0001081)7.64423710
5Diaphragmatic weakness (HP:0009113)7.37772343
6Abnormal gallbladder morphology (HP:0012437)6.92279360
7Paralysis (HP:0003470)6.10263396
8Insomnia (HP:0100785)5.55598023
9Hyperbilirubinemia (HP:0002904)5.55359008
10Abnormality of reticulocytes (HP:0004312)5.52738732
11Hypochromic anemia (HP:0001931)5.24562584
12Osteomalacia (HP:0002749)4.84265148
13Microcytic anemia (HP:0001935)4.83830355
14Abnormality of the gallbladder (HP:0005264)4.75630272
15Cutaneous photosensitivity (HP:0000992)4.60956619
16Abnormal gallbladder physiology (HP:0012438)4.59847573
17Cholecystitis (HP:0001082)4.59847573
18Ileus (HP:0002595)4.58126467
19Abnormal number of erythroid precursors (HP:0012131)3.41254649
20Hepatocellular carcinoma (HP:0001402)3.36146754
21Birth length less than 3rd percentile (HP:0003561)3.28705404
22Polycythemia (HP:0001901)3.22651634
23Hyponatremia (HP:0002902)3.21141957
24Abnormality of cells of the erythroid lineage (HP:0012130)3.17694873
25Toxemia of pregnancy (HP:0100603)3.02468941
26Abnormality of sodium homeostasis (HP:0010931)2.94164243
27Truncus arteriosus (HP:0001660)2.84278086
28Nausea (HP:0002018)2.81512829
29Increased serum ferritin (HP:0003281)2.73881675
30Petechiae (HP:0000967)2.73251281
31Abnormality of homocysteine metabolism (HP:0010919)2.69009018
32Homocystinuria (HP:0002156)2.69009018
33Urticaria (HP:0001025)2.63902704
34Short middle phalanx of the 5th finger (HP:0004220)2.55915249
35Onycholysis (HP:0001806)2.49879646
36Confusion (HP:0001289)2.48428982
37Abnormality of iron homeostasis (HP:0011031)2.43975970
38Delusions (HP:0000746)2.40379328
39Hypoparathyroidism (HP:0000829)2.40074345
40Global brain atrophy (HP:0002283)2.36196763
41Aplasia/Hypoplasia of the earlobes (HP:0009906)2.33285314
42Hyperthyroidism (HP:0000836)2.29928849
43Prolonged bleeding time (HP:0003010)2.28981872
44Hypertensive crisis (HP:0100735)2.23517458
45Cerebral palsy (HP:0100021)2.22797754
46Abnormality of transition element cation homeostasis (HP:0011030)2.22500151
47Pustule (HP:0200039)2.21576370
48Macrocytic anemia (HP:0001972)2.15189613
49Generalized hyperpigmentation (HP:0007440)2.11310044
50Bowel incontinence (HP:0002607)2.06841048
51Abnormality of the heme biosynthetic pathway (HP:0010472)15.2466746
52Poikilocytosis (HP:0004447)14.0656201
53Hypochromic microcytic anemia (HP:0004840)10.7647449
54Ankyloglossia (HP:0010296)1.99961932
55Abnormal large intestine physiology (HP:0012700)1.99321704
56Orthostatic hypotension (HP:0001278)1.96165495
57Gastrointestinal infarctions (HP:0005244)1.94905497
58Pathologic fracture (HP:0002756)1.92115365
59Renal tubular acidosis (HP:0001947)1.90522398
60Lower limb hyperreflexia (HP:0002395)1.87917214
61Acute myeloid leukemia (HP:0004808)1.87165021
62Childhood onset (HP:0011463)1.79553878
63Depression (HP:0000716)1.79153361
64Myelodysplasia (HP:0002863)1.74151956
65Duplicated collecting system (HP:0000081)1.71833701
66Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71763380
67Pallor (HP:0000980)1.62898152
68Neoplasm of head and neck (HP:0012288)1.62632249
69Esophageal neoplasm (HP:0100751)1.62632249
70Autoamputation (HP:0001218)1.62203454
71Neoplasm of the liver (HP:0002896)1.61115338
72Epistaxis (HP:0000421)1.60321941
73Abnormal blistering of the skin (HP:0008066)1.60107784
74Nonimmune hydrops fetalis (HP:0001790)1.59367251
75Limb hypertonia (HP:0002509)1.57681293
76Submucous cleft hard palate (HP:0000176)1.55730001
77Basal cell carcinoma (HP:0002671)1.55648277
78High pitched voice (HP:0001620)1.54815281
79Osteomyelitis (HP:0002754)1.54556224
80Abnormality of nail color (HP:0100643)1.54092831
81Breast hypoplasia (HP:0003187)1.53417101
82Cafe-au-lait spot (HP:0000957)1.51993479
83Purpura (HP:0000979)1.51532641
84Peripheral hypomyelination (HP:0007182)1.51070493
85Hypertriglyceridemia (HP:0002155)1.50708282
86Long clavicles (HP:0000890)1.48243618
87Ureteral duplication (HP:0000073)1.48121034
88Abnormality of the fingertips (HP:0001211)1.47622353
89Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.46306664
90Biliary tract neoplasm (HP:0100574)1.45855811
91Anxiety (HP:0000739)1.45216441
92Broad palm (HP:0001169)1.44928265
93Seborrheic dermatitis (HP:0001051)1.42940859
94Small intestinal stenosis (HP:0012848)1.41246071
95Duodenal stenosis (HP:0100867)1.41246071
96Spinal muscular atrophy (HP:0007269)1.41216628
97Abnormality of the renal collecting system (HP:0004742)1.41060877
98Neoplasm of the small intestine (HP:0100833)1.40939328
99Abnormality of dental color (HP:0011073)1.38575791
100Thin skin (HP:0000963)1.38086915
101Gastrointestinal dysmotility (HP:0002579)1.38063311
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.37814830
103Thyroid carcinoma (HP:0002890)1.37402565
104Rectal prolapse (HP:0002035)1.36300076
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.35282726
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.34928592
107Erythema (HP:0010783)1.33910641
108Autoimmune hemolytic anemia (HP:0001890)1.32947557
109Ventricular fibrillation (HP:0001663)1.32942882
110Hypopigmented skin patches (HP:0001053)1.32465449
111Absent epiphyses (HP:0010577)1.32386523
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.32386523
113Abnormality of the tricuspid valve (HP:0001702)1.31864959
114Paresthesia (HP:0003401)1.31783985
115Impaired platelet aggregation (HP:0003540)1.31468549
116Abnormal platelet function (HP:0011869)1.31468549
117Albinism (HP:0001022)1.31277053
118Rickets (HP:0002748)1.31237242
119Bone marrow hypocellularity (HP:0005528)1.30601212
120Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.30268529
121Sandal gap (HP:0001852)1.30195304
122Short 5th finger (HP:0009237)1.28332271
123Gonadal dysgenesis (HP:0000133)1.27874248
124Abnormality of cochlea (HP:0000375)1.27120667
125Abnormality of oral frenula (HP:0000190)1.25868457
126Abnormality of chromosome stability (HP:0003220)1.25188418
127Prominent nose (HP:0000448)1.24029901
128Cortical visual impairment (HP:0100704)1.23839381
129Neoplasm of the rectum (HP:0100743)1.22281896
130Tinnitus (HP:0000360)1.22045742
131Chromsome breakage (HP:0040012)1.20960295
132Papilloma (HP:0012740)1.20952123
133Verrucae (HP:0200043)1.20952123
134Autoimmune thrombocytopenia (HP:0001973)1.19359538
135Abnormal platelet volume (HP:0011876)1.19067939
136Increased mean platelet volume (HP:0011877)1.17915090
137Impulsivity (HP:0100710)1.17681593
138Abnormal auditory evoked potentials (HP:0006958)1.16054484
139Patellar aplasia (HP:0006443)1.15512973
140Cortical dysplasia (HP:0002539)1.15469313
141Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.15232636
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.14554835
143Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.14473440
144Papilledema (HP:0001085)1.13997606
145Metabolic acidosis (HP:0001942)1.13205950
146Hemorrhage of the eye (HP:0011885)1.11491946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK16.45791135
2TLK16.14726853
3STK44.15907259
4CDK123.94645738
5ZAK3.88192166
6CDC73.66641037
7PRPF4B3.30005020
8VRK12.91951105
9RIPK42.53377483
10BRSK12.39708073
11RPS6KA52.01146637
12DYRK31.95372690
13STK101.91714920
14NEK21.91689220
15PIM11.89938065
16TAOK21.87078513
17MAP3K81.78576375
18AURKB1.75042798
19NME21.72593762
20BUB11.71646050
21WNK11.66037306
22BRD41.62282019
23GRK61.60918784
24WEE11.54507068
25SCYL21.47746407
26KSR21.42426619
27RAF11.41517208
28AURKA1.41157243
29EIF2AK31.40785081
30TRPM71.36869141
31BRSK21.33821440
32PBK1.33330754
33NEK11.27934239
34KSR11.21737120
35TTK1.21164841
36EEF2K1.20100366
37CDK61.16379607
38PRKAA11.16003455
39MAP3K21.12322079
40BMPR21.12286893
41MAPK111.11842932
42CHEK21.11807289
43PLK11.11071921
44MST41.10376057
45GRK51.09630358
46MAPKAPK31.08878364
47CDK41.03163882
48PLK20.99437001
49MAP3K110.87297002
50NUAK10.86650307
51SYK0.86645539
52CDK90.85607504
53NTRK30.85071070
54TEC0.84568190
55ERBB20.83044199
56CHEK10.82763075
57ABL20.80004343
58MAPKAPK50.79408580
59MAP3K100.76512414
60JAK20.75062442
61ATR0.71850805
62MELK0.70485300
63BRAF0.70066566
64DAPK20.68987897
65TAOK10.68691808
66ATM0.67827023
67CAMK1D0.66184059
68DYRK1B0.63601716
69MAP3K60.61261055
70MAP3K10.60985361
71STK30.60451218
72PLK30.59722991
73TGFBR20.57297811
74CDK70.55724352
75SGK10.55666898
76HIPK20.54786466
77EIF2AK20.51598882
78STK240.50656399
79CDK20.50224270
80RPS6KC10.49555629
81RPS6KL10.49555629
82CDK10.49522414
83RPS6KB20.48540715
84GRK70.48508378
85MAP3K30.48018405
86MAP3K50.47869332
87MAP3K40.47577978
88RPS6KA40.47312288
89ICK0.47049953
90IKBKE0.44957906
91MKNK10.44449847
92TAOK30.43430004
93RPS6KA60.41140026
94MAPKAPK20.41026684
95LYN0.40280345
96ACVR1B0.39999952
97PTK2B0.39302377
98MKNK20.39179024
99BTK0.38525705
100PKN10.38229555
101SGK30.37881049
102CDC42BPA0.37706627
103MAP2K10.37625794
104CSNK1D0.36740918
105CDK150.35902693
106CDK11A0.33827095
107DYRK1A0.33431068
108SRPK10.32690480
109AKT20.30982104
110MAP2K30.30853247
111CDK180.30213119
112CLK10.29946408
113PRKCD0.29606493
114BMX0.29388818
115PRKACG0.28991833
116NME10.28789561
117MAPK30.28056077
118AKT30.27872446
119MAP4K10.27814560
120RPS6KA30.27275576
121FGR0.27138570
122CDK140.27071915
123DMPK0.27047820
124MAP2K20.25791038
125CSNK2A20.25317327
126CSNK2A10.25139238
127LRRK20.24872999
128AKT10.24718800
129JAK30.24038651
130YES10.23975548
131PLK40.23760257
132MARK30.23735522
133MAPK140.23692267
134PRKDC0.23636340
135CCNB10.22678702
136PRKAA20.22094163
137IKBKB0.20895595
138FLT30.20045213
139PAK10.19204866
140PRKCB0.18543061

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008609.25160541
2Systemic lupus erythematosus_Homo sapiens_hsa053227.53548641
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.04988394
4Alcoholism_Homo sapiens_hsa050344.18336465
5Vitamin B6 metabolism_Homo sapiens_hsa007503.89926606
6DNA replication_Homo sapiens_hsa030303.48318376
7Cell cycle_Homo sapiens_hsa041102.66223640
8Viral carcinogenesis_Homo sapiens_hsa052032.16247207
9Mismatch repair_Homo sapiens_hsa034301.99068480
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80550328
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57951494
12Nucleotide excision repair_Homo sapiens_hsa034201.53932585
13ABC transporters_Homo sapiens_hsa020101.52399274
14Sulfur relay system_Homo sapiens_hsa041221.51894304
15African trypanosomiasis_Homo sapiens_hsa051431.49157246
16Base excision repair_Homo sapiens_hsa034101.46580735
17Homologous recombination_Homo sapiens_hsa034401.42118908
18One carbon pool by folate_Homo sapiens_hsa006701.37590159
19p53 signaling pathway_Homo sapiens_hsa041151.35876533
20Fanconi anemia pathway_Homo sapiens_hsa034601.35744807
21Acute myeloid leukemia_Homo sapiens_hsa052211.31519808
22Ribosome_Homo sapiens_hsa030101.19908169
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09398225
24Type II diabetes mellitus_Homo sapiens_hsa049301.04040996
25mTOR signaling pathway_Homo sapiens_hsa041501.02502969
26Renal cell carcinoma_Homo sapiens_hsa052111.01484164
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00445786
28HIF-1 signaling pathway_Homo sapiens_hsa040660.98779164
29Collecting duct acid secretion_Homo sapiens_hsa049660.96413570
30Pyrimidine metabolism_Homo sapiens_hsa002400.96390051
31Spliceosome_Homo sapiens_hsa030400.95892544
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94992055
33RNA transport_Homo sapiens_hsa030130.94297362
34Oocyte meiosis_Homo sapiens_hsa041140.94215003
35SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93583798
36Glutathione metabolism_Homo sapiens_hsa004800.93106586
37Proteasome_Homo sapiens_hsa030500.92395941
38Bladder cancer_Homo sapiens_hsa052190.91801034
39Selenocompound metabolism_Homo sapiens_hsa004500.89169051
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81769184
41Non-homologous end-joining_Homo sapiens_hsa034500.81729541
42Non-small cell lung cancer_Homo sapiens_hsa052230.81241991
43Steroid biosynthesis_Homo sapiens_hsa001000.79890385
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79688949
45Herpes simplex infection_Homo sapiens_hsa051680.77965500
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76816296
47Dorso-ventral axis formation_Homo sapiens_hsa043200.71870681
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.68089046
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67716874
50Folate biosynthesis_Homo sapiens_hsa007900.67590664
51Olfactory transduction_Homo sapiens_hsa047400.67558595
52Apoptosis_Homo sapiens_hsa042100.66361170
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66245119
54Small cell lung cancer_Homo sapiens_hsa052220.62060853
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61653163
56Butanoate metabolism_Homo sapiens_hsa006500.60737876
57Chronic myeloid leukemia_Homo sapiens_hsa052200.59309807
58Fructose and mannose metabolism_Homo sapiens_hsa000510.58099202
59Parkinsons disease_Homo sapiens_hsa050120.56904538
60* Hematopoietic cell lineage_Homo sapiens_hsa046400.56353155
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.55027347
62Caffeine metabolism_Homo sapiens_hsa002320.54699265
63mRNA surveillance pathway_Homo sapiens_hsa030150.54304322
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.54175908
65Insulin signaling pathway_Homo sapiens_hsa049100.53440388
66Inositol phosphate metabolism_Homo sapiens_hsa005620.52617969
67B cell receptor signaling pathway_Homo sapiens_hsa046620.51296208
68Propanoate metabolism_Homo sapiens_hsa006400.51022734
69Protein export_Homo sapiens_hsa030600.50200033
70Prolactin signaling pathway_Homo sapiens_hsa049170.49772007
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.48000857
72Fatty acid metabolism_Homo sapiens_hsa012120.44878089
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44857614
74Hepatitis B_Homo sapiens_hsa051610.43504901
75Pyruvate metabolism_Homo sapiens_hsa006200.42994205
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.42617731
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41879022
78RNA degradation_Homo sapiens_hsa030180.39729040
79RNA polymerase_Homo sapiens_hsa030200.38080151
80AMPK signaling pathway_Homo sapiens_hsa041520.36948400
81Huntingtons disease_Homo sapiens_hsa050160.36738333
82Purine metabolism_Homo sapiens_hsa002300.36293051
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35489730
84Endometrial cancer_Homo sapiens_hsa052130.35132228
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34692380
86Measles_Homo sapiens_hsa051620.34358337
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33825494
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33581323
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33224651
90Epstein-Barr virus infection_Homo sapiens_hsa051690.32297549
91Pancreatic cancer_Homo sapiens_hsa052120.32014673
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30689301
93Prostate cancer_Homo sapiens_hsa052150.30322829
94FoxO signaling pathway_Homo sapiens_hsa040680.30144417
95HTLV-I infection_Homo sapiens_hsa051660.27364294
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26923580
97Pentose phosphate pathway_Homo sapiens_hsa000300.25993821
98Metabolic pathways_Homo sapiens_hsa011000.25231501
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24839641
100Lysine degradation_Homo sapiens_hsa003100.24196232
101* Malaria_Homo sapiens_hsa051440.23220093
102Glioma_Homo sapiens_hsa052140.22152793
103Basal transcription factors_Homo sapiens_hsa030220.19632717
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19272271
105MicroRNAs in cancer_Homo sapiens_hsa052060.19090555
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18957980
107Complement and coagulation cascades_Homo sapiens_hsa046100.17719398
108Biosynthesis of amino acids_Homo sapiens_hsa012300.17388379
109Thyroid cancer_Homo sapiens_hsa052160.12809807
110beta-Alanine metabolism_Homo sapiens_hsa004100.12691956
111Antigen processing and presentation_Homo sapiens_hsa046120.12636972
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.12617181
113Bile secretion_Homo sapiens_hsa049760.12324791
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.12264904
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.11818684
116Hepatitis C_Homo sapiens_hsa051600.10916920
117Carbon metabolism_Homo sapiens_hsa012000.10749284
118Influenza A_Homo sapiens_hsa051640.10448534
119Regulation of autophagy_Homo sapiens_hsa041400.09420780
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08517793
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.06492489
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05937469
123Oxidative phosphorylation_Homo sapiens_hsa001900.03012716
124Platelet activation_Homo sapiens_hsa046110.02910865
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02893365
126Alzheimers disease_Homo sapiens_hsa050100.00805719
127Nitrogen metabolism_Homo sapiens_hsa009100.00506499
128Tryptophan metabolism_Homo sapiens_hsa003800.00072376
129Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0212989
130Melanoma_Homo sapiens_hsa05218-0.0034942

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