GYPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound biosynthetic process (GO:0006779)9.11427462
2hemoglobin metabolic process (GO:0020027)8.31492657
3regulation of response to osmotic stress (GO:0047484)8.20223074
4tetrapyrrole biosynthetic process (GO:0033014)8.15268554
5porphyrin-containing compound metabolic process (GO:0006778)7.62328242
6heme biosynthetic process (GO:0006783)7.47938755
7heme metabolic process (GO:0042168)6.38295690
8erythrocyte development (GO:0048821)6.27573081
9phospholipid scrambling (GO:0017121)6.03272079
10response to methylmercury (GO:0051597)5.39258307
11tetrapyrrole metabolic process (GO:0033013)4.99988758
12DNA replication-dependent nucleosome organization (GO:0034723)4.40400288
13DNA replication-dependent nucleosome assembly (GO:0006335)4.40400288
14myeloid cell development (GO:0061515)4.39254723
15somite rostral/caudal axis specification (GO:0032525)4.35970329
16iron ion import (GO:0097286)4.35432775
17one-carbon compound transport (GO:0019755)4.01385250
18granulocyte differentiation (GO:0030851)3.91476719
19DNA replication checkpoint (GO:0000076)3.87883499
20proteasome assembly (GO:0043248)3.85393738
21CENP-A containing nucleosome assembly (GO:0034080)3.84992860
22autophagic vacuole fusion (GO:0000046)3.79478726
23DNA double-strand break processing (GO:0000729)3.77923761
24protein-cofactor linkage (GO:0018065)3.75276506
25definitive hemopoiesis (GO:0060216)3.74189932
26response to insecticide (GO:0017085)3.67131559
27glycine transport (GO:0015816)3.58172045
28chromatin remodeling at centromere (GO:0031055)3.52234490
29negative regulation of viral entry into host cell (GO:0046597)3.49404614
30pigment biosynthetic process (GO:0046148)3.44396287
31histone exchange (GO:0043486)3.44106548
32meiotic chromosome segregation (GO:0045132)3.35112060
33DNA replication-independent nucleosome organization (GO:0034724)3.32115808
34DNA replication-independent nucleosome assembly (GO:0006336)3.32115808
35mitotic G2/M transition checkpoint (GO:0044818)3.31752485
36regulation of mesoderm development (GO:2000380)3.31512130
37DNA deamination (GO:0045006)3.29968389
38response to lead ion (GO:0010288)3.27368070
39erythrocyte differentiation (GO:0030218)3.27255453
40negative regulation of activin receptor signaling pathway (GO:0032926)3.26374930
41endoderm formation (GO:0001706)3.26146866
42hydrogen peroxide catabolic process (GO:0042744)3.23901582
43organelle membrane fusion (GO:0090174)3.19551497
44primitive streak formation (GO:0090009)3.19010101
45actin filament capping (GO:0051693)3.17561691
46mitotic G2 DNA damage checkpoint (GO:0007095)3.14181368
47positive regulation of megakaryocyte differentiation (GO:0045654)3.14162865
48anterior/posterior axis specification (GO:0009948)3.07332913
49sequestering of extracellular ligand from receptor (GO:0035581)3.06702919
50L-serine transport (GO:0015825)3.04199106
51very-low-density lipoprotein particle assembly (GO:0034379)3.04125103
52megakaryocyte development (GO:0035855)3.03417548
53terpenoid biosynthetic process (GO:0016114)3.03127921
54pigment metabolic process (GO:0042440)3.02676234
55N-terminal protein amino acid acetylation (GO:0006474)3.02185269
56regulation of oxidative phosphorylation (GO:0002082)3.00632969
57serine transport (GO:0032329)3.00501801
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.98642787
59mRNA cleavage (GO:0006379)2.91514578
60bicarbonate transport (GO:0015701)2.86946549
61histone mRNA metabolic process (GO:0008334)2.85974664
62positive regulation of granulocyte differentiation (GO:0030854)2.85292413
63histone mRNA catabolic process (GO:0071044)2.77742919
64kinetochore organization (GO:0051383)2.72318210
65DNA topological change (GO:0006265)2.70353080
66embryonic hemopoiesis (GO:0035162)2.69979277
67negative regulation of erythrocyte differentiation (GO:0045647)2.69413449
68mitotic sister chromatid segregation (GO:0000070)2.64521517
69innate immune response in mucosa (GO:0002227)2.61358758
70positive regulation of erythrocyte differentiation (GO:0045648)2.54254047
71response to arsenic-containing substance (GO:0046685)2.52753047
72positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.52165689
73regulation of erythrocyte differentiation (GO:0045646)2.52054951
74cellular response to oxygen radical (GO:0071450)2.47120854
75removal of superoxide radicals (GO:0019430)2.47120854
76cellular response to superoxide (GO:0071451)2.47120854
77antibacterial humoral response (GO:0019731)2.46801391
78replication fork processing (GO:0031297)2.46585604
79synapsis (GO:0007129)2.44727284
80sister chromatid segregation (GO:0000819)2.42669672
81negative regulation of protein acetylation (GO:1901984)2.40548090
82regulation of viral entry into host cell (GO:0046596)2.39987061
83regulation of metalloenzyme activity (GO:0048552)2.38613088
84embryonic axis specification (GO:0000578)2.38077209
85neutrophil activation involved in immune response (GO:0002283)2.37574441
86protein K11-linked deubiquitination (GO:0035871)2.36802411
87cellular response to arsenic-containing substance (GO:0071243)2.36740056
88response to superoxide (GO:0000303)2.36473926
89response to oxygen radical (GO:0000305)2.34756088
90regulation of RNA export from nucleus (GO:0046831)2.33444901
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.31980322
92postreplication repair (GO:0006301)2.31354365
93mitotic nuclear envelope disassembly (GO:0007077)2.30333530
94cerebellar Purkinje cell differentiation (GO:0021702)2.29644077
95regulation of meiosis I (GO:0060631)2.28958765
96oxygen transport (GO:0015671)16.2693720
97gas transport (GO:0015669)14.5980057
98protoporphyrinogen IX metabolic process (GO:0046501)12.4543426
99protoporphyrinogen IX biosynthetic process (GO:0006782)10.5387077
100erythrocyte maturation (GO:0043249)10.0234615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26988498
2GATA1_22025678_ChIP-Seq_K562_Human6.17492042
3GATA1_19941826_ChIP-Seq_K562_Human5.28520065
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.81104937
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80960670
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50989336
7GATA2_19941826_ChIP-Seq_K562_Human3.40779065
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.14929376
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96168801
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.69215838
11KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.54145558
12ELK1_19687146_ChIP-ChIP_HELA_Human2.48076734
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40450600
14AR_21909140_ChIP-Seq_LNCAP_Human2.28915200
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.21414654
16VDR_22108803_ChIP-Seq_LS180_Human2.02779299
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95864969
18NCOR1_26117541_ChIP-Seq_K562_Human1.95559056
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90369296
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85198038
21VDR_23849224_ChIP-Seq_CD4+_Human1.83872442
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79020574
23HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74088096
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72424872
25SCL_19346495_ChIP-Seq_HPC-7_Human1.72281986
26FOXP3_21729870_ChIP-Seq_TREG_Human1.71099448
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69962347
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.69533358
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68206704
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66275211
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.64626646
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.62685207
33DCP1A_22483619_ChIP-Seq_HELA_Human1.59188722
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59085272
35TP53_22573176_ChIP-Seq_HFKS_Human1.57662586
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.51380743
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50327123
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50327123
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50327123
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.48620004
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47235625
42SALL4_22934838_ChIP-ChIP_CD34+_Human1.44775951
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44357212
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40801027
45EOMES_21245162_ChIP-Seq_HESCs_Human1.40797213
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35021697
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34596922
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33758990
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30693311
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.27663793
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.26658259
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25873987
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23992475
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.23621837
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22965796
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17710694
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13443131
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.09679712
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09444918
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09237809
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08255087
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07292879
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07039178
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04843880
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04330119
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.03290041
67SMAD4_21741376_ChIP-Seq_HESCs_Human1.01038148
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99993261
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93979400
70RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92869499
71GABP_19822575_ChIP-Seq_HepG2_Human0.92652033
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91864458
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91229423
74MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85600012
75PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85561137
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85059019
77GATA1_26923725_Chip-Seq_HPCs_Mouse0.83457287
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83225152
79MYC_18940864_ChIP-ChIP_HL60_Human0.82537291
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81990208
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81723303
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81407957
83SPI1_23547873_ChIP-Seq_NB4_Human0.80522706
84RBPJ_21746931_ChIP-Seq_IB4_Human0.79885617
85TTF2_22483619_ChIP-Seq_HELA_Human0.79265033
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78489489
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78472453
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77934398
89EWS_26573619_Chip-Seq_HEK293_Human0.75510626
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74669355
91TFEB_21752829_ChIP-Seq_HELA_Human0.73162641
92ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73140929
93GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72870861
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72577413
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.72167294
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.71456674
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.71225445
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.70664153
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70193783
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69886178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo7.57637909
2MP0003890_abnormal_embryonic-extraembry4.73126639
3MP0005083_abnormal_biliary_tract4.10963908
4MP0008995_early_reproductive_senescence4.00128836
5MP0003786_premature_aging2.71374981
6MP0004957_abnormal_blastocyst_morpholog2.60922909
7MP0008004_abnormal_stomach_pH2.41500884
8MP0001545_abnormal_hematopoietic_system2.24861413
9MP0005397_hematopoietic_system_phenotyp2.24861413
10MP0009697_abnormal_copulation2.07609347
11MP0003186_abnormal_redox_activity2.00670584
12MP0004147_increased_porphyrin_level10.3610064
13MP0003111_abnormal_nucleus_morphology1.95653356
14MP0010094_abnormal_chromosome_stability1.85920559
15MP0001661_extended_life_span1.84307517
16MP0005636_abnormal_mineral_homeostasis1.83795357
17MP0006054_spinal_hemorrhage1.77638068
18MP0000372_irregular_coat_pigmentation1.74838129
19MP0005377_hearing/vestibular/ear_phenot1.66793123
20MP0003878_abnormal_ear_physiology1.66793123
21MP0008058_abnormal_DNA_repair1.60121613
22MP0001529_abnormal_vocalization1.53679179
23MP0006036_abnormal_mitochondrial_physio1.53187067
24MP0002396_abnormal_hematopoietic_system1.45183934
25MP0005171_absent_coat_pigmentation1.40471095
26MP0008775_abnormal_heart_ventricle1.35302037
27MP0004145_abnormal_muscle_electrophysio1.23393128
28MP0003119_abnormal_digestive_system1.20455014
29MP0003077_abnormal_cell_cycle1.17358301
30MP0005380_embryogenesis_phenotype1.15282696
31MP0001672_abnormal_embryogenesis/_devel1.15282696
32MP0005187_abnormal_penis_morphology1.14303268
33MP0002132_abnormal_respiratory_system1.10025243
34MP0004885_abnormal_endolymph1.00605580
35MP0003984_embryonic_growth_retardation0.98962700
36MP0002088_abnormal_embryonic_growth/wei0.98894808
37MP0002086_abnormal_extraembryonic_tissu0.98811354
38MP0006035_abnormal_mitochondrial_morpho0.98079849
39MP0008260_abnormal_autophagy0.97209263
40MP0005076_abnormal_cell_differentiation0.96461641
41MP0008872_abnormal_physiological_respon0.95136066
42MP0005075_abnormal_melanosome_morpholog0.94925838
43MP0004215_abnormal_myocardial_fiber0.92330811
44MP0002084_abnormal_developmental_patter0.91915188
45MP0000313_abnormal_cell_death0.88353755
46MP0005394_taste/olfaction_phenotype0.87274731
47MP0005499_abnormal_olfactory_system0.87274731
48MP0001697_abnormal_embryo_size0.86819867
49MP0002722_abnormal_immune_system0.86187707
50MP0009278_abnormal_bone_marrow0.86178445
51MP0005275_abnormal_skin_tensile0.84747910
52MP0001929_abnormal_gametogenesis0.84317252
53MP0002080_prenatal_lethality0.84130395
54MP0002210_abnormal_sex_determination0.83489219
55MP0000015_abnormal_ear_pigmentation0.82802709
56MP0001730_embryonic_growth_arrest0.82373486
57MP0000689_abnormal_spleen_morphology0.81184455
58MP0000749_muscle_degeneration0.80980089
59MP0008057_abnormal_DNA_replication0.80564148
60MP0002398_abnormal_bone_marrow0.76647087
61MP0005464_abnormal_platelet_physiology0.75426195
62MP0002102_abnormal_ear_morphology0.74762263
63MP0010307_abnormal_tumor_latency0.73670953
64MP0008438_abnormal_cutaneous_collagen0.73376140
65MP0004808_abnormal_hematopoietic_stem0.72541871
66MP0009931_abnormal_skin_appearance0.70682743
67MP0002095_abnormal_skin_pigmentation0.69294292
68MP0000653_abnormal_sex_gland0.65935089
69MP0001119_abnormal_female_reproductive0.65639513
70MP0003943_abnormal_hepatobiliary_system0.64435976
71MP0000358_abnormal_cell_content/0.63855536
72MP0000350_abnormal_cell_proliferation0.63537859
73MP0003567_abnormal_fetal_cardiomyocyte0.62244657
74MP0003137_abnormal_impulse_conducting0.61798079
75MP0003698_abnormal_male_reproductive0.61111326
76MP0002085_abnormal_embryonic_tissue0.60763789
77MP0006072_abnormal_retinal_apoptosis0.60025617
78MP0003195_calcinosis0.59673574
79MP0002429_abnormal_blood_cell0.57345415
80MP0001145_abnormal_male_reproductive0.56574154
81MP0008932_abnormal_embryonic_tissue0.56128031
82MP0009765_abnormal_xenobiotic_induced0.54832088
83MP0005174_abnormal_tail_pigmentation0.54774108
84MP0005220_abnormal_exocrine_pancreas0.53500219
85MP0003303_peritoneal_inflammation0.53380701
86MP0001293_anophthalmia0.52005478
87MP0009764_decreased_sensitivity_to0.51089949
88MP0003718_maternal_effect0.50842845
89MP0002111_abnormal_tail_morphology0.50765490
90MP0000598_abnormal_liver_morphology0.50181073
91MP0001485_abnormal_pinna_reflex0.50177641
92MP0003191_abnormal_cellular_cholesterol0.48522093
93MP0002019_abnormal_tumor_incidence0.47550247
94MP0000609_abnormal_liver_physiology0.47331178
95MP0003221_abnormal_cardiomyocyte_apopto0.46804929
96MP0005167_abnormal_blood-brain_barrier0.45005272
97MP0005384_cellular_phenotype0.44598755
98MP0008877_abnormal_DNA_methylation0.44267129
99MP0004185_abnormal_adipocyte_glucose0.43221014
100MP0000703_abnormal_thymus_morphology0.43006417

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.82767146
2Hypochromic microcytic anemia (HP:0004840)7.89100893
3Reticulocytosis (HP:0001923)6.21887772
4Microcytic anemia (HP:0001935)5.72590826
5Acanthocytosis (HP:0001927)5.29917711
6Paralysis (HP:0003470)4.51663938
7Hypochromic anemia (HP:0001931)4.39079762
8Abnormality of reticulocytes (HP:0004312)4.35746592
9Cholelithiasis (HP:0001081)4.20541025
10Polycythemia (HP:0001901)4.18164151
11Abnormal gallbladder morphology (HP:0012437)3.85147133
12Hyperbilirubinemia (HP:0002904)3.57092163
13Diaphragmatic weakness (HP:0009113)3.52981204
14Pallor (HP:0000980)3.48090886
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22299762
16Ileus (HP:0002595)3.17842027
17Gonadal dysgenesis (HP:0000133)3.04335276
18Homocystinuria (HP:0002156)3.03028005
19Abnormality of homocysteine metabolism (HP:0010919)3.03028005
20Ureteral duplication (HP:0000073)2.94819570
21Toxemia of pregnancy (HP:0100603)2.94226887
22Chromsome breakage (HP:0040012)2.88073993
23Nausea (HP:0002018)2.85062013
24Abnormality of the gallbladder (HP:0005264)2.77731216
25Abnormal gallbladder physiology (HP:0012438)2.73632682
26Cholecystitis (HP:0001082)2.73632682
27Abnormal umbilical cord blood vessels (HP:0011403)2.73055228
28Single umbilical artery (HP:0001195)2.73055228
29Abnormality of the fetal cardiovascular system (HP:0010948)2.73055228
30Hepatocellular carcinoma (HP:0001402)2.46721806
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.43737933
32Short middle phalanx of the 5th finger (HP:0004220)2.39967140
33Submucous cleft hard palate (HP:0000176)2.38583932
34Abnormality of the umbilical cord (HP:0010881)2.32570382
35Cerebral palsy (HP:0100021)2.32496644
36Abnormality of chromosome stability (HP:0003220)2.31572123
37Abnormal pancreas size (HP:0012094)2.20026056
38Congenital, generalized hypertrichosis (HP:0004540)2.13813575
39Truncus arteriosus (HP:0001660)2.11824114
40Biliary tract neoplasm (HP:0100574)2.09547087
41Meckel diverticulum (HP:0002245)2.02553491
42Abnormality of the heme biosynthetic pathway (HP:0010472)14.0079578
43Abnormal hemoglobin (HP:0011902)10.9553435
44Abnormality of transition element cation homeostasis (HP:0011030)1.98857398
45Premature rupture of membranes (HP:0001788)1.95681158
46Stillbirth (HP:0003826)1.89110187
47Degeneration of anterior horn cells (HP:0002398)1.88229635
48Abnormality of the anterior horn cell (HP:0006802)1.88229635
49Abnormality of the ileum (HP:0001549)1.86526486
50Neoplasm of the liver (HP:0002896)1.85508495
51Abnormality of iron homeostasis (HP:0011031)1.85477934
52Neoplasm of the small intestine (HP:0100833)1.85302729
53Exertional dyspnea (HP:0002875)1.83335447
54Spinal muscular atrophy (HP:0007269)1.83067219
55Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80724522
56Duplicated collecting system (HP:0000081)1.80553881
57Abnormality of the preputium (HP:0100587)1.78378333
58Cutaneous photosensitivity (HP:0000992)1.78060122
59Methylmalonic acidemia (HP:0002912)1.74518912
60Cortical dysplasia (HP:0002539)1.73709031
61Neoplasm of the rectum (HP:0100743)1.72807685
62Abdominal situs inversus (HP:0003363)1.72156274
63Abnormality of abdominal situs (HP:0011620)1.72156274
64Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71788123
65Ankyloglossia (HP:0010296)1.69969353
66Abnormal biliary tract morphology (HP:0012440)1.68850971
67Duodenal stenosis (HP:0100867)1.67256274
68Small intestinal stenosis (HP:0012848)1.67256274
69Hyponatremia (HP:0002902)1.63748228
70Abnormal lung lobation (HP:0002101)1.62563849
71Prolonged bleeding time (HP:0003010)1.61833956
72Rectal fistula (HP:0100590)1.61010606
73Rectovaginal fistula (HP:0000143)1.61010606
74Osteomalacia (HP:0002749)1.60783368
75Hypertensive crisis (HP:0100735)1.60242844
76Congenital malformation of the right heart (HP:0011723)1.54656721
77Double outlet right ventricle (HP:0001719)1.54656721
78Myelodysplasia (HP:0002863)1.54000437
79Gastrointestinal infarctions (HP:0005244)1.53397529
80Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52712245
81Esophageal neoplasm (HP:0100751)1.50183336
82Neoplasm of head and neck (HP:0012288)1.50183336
83Abnormal number of erythroid precursors (HP:0012131)1.48891916
84Abnormalities of placenta or umbilical cord (HP:0001194)1.47165934
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.46827275
86Abnormality of the renal collecting system (HP:0004742)1.45631868
87Gonadotropin excess (HP:0000837)1.45575913
88Intestinal fistula (HP:0100819)1.45233181
89Nonimmune hydrops fetalis (HP:0001790)1.43698748
90Mesomelia (HP:0003027)1.43280752
91Stomach cancer (HP:0012126)1.41160996
92Abnormality of the duodenum (HP:0002246)1.40824023
93Albinism (HP:0001022)1.40491582
94Ovarian neoplasm (HP:0100615)1.38219814
95Clubbing of toes (HP:0100760)1.38127393
96Hypoplastic pelvis (HP:0008839)1.37896568
97Bone marrow hypocellularity (HP:0005528)1.35649647
98Peritonitis (HP:0002586)1.34384926
99Abnormality of sodium homeostasis (HP:0010931)1.33530657
100Oligohydramnios (HP:0001562)1.32868666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK18.42763544
2ACVR1B3.17902194
3MST43.02417685
4EIF2AK32.67033764
5PLK42.65921754
6NUAK12.43718800
7PBK2.39584277
8TRIM282.28146072
9ZAK2.07259119
10CLK12.02795102
11BMPR1B1.97245274
12MAP2K31.92496899
13ERBB31.81363636
14WEE11.79330142
15MAP3K41.78942767
16PLK21.78459629
17TRPM71.74779435
18PLK31.74224411
19CDC71.65171961
20MKNK21.61703258
21BRSK21.60799527
22SIK31.60728058
23STK41.48175812
24GRK61.44377543
25ERBB41.43838218
26WNK31.39931821
27RAF11.34403257
28NEK11.28979442
29TTK1.21998196
30DYRK31.20266072
31BRSK11.19052991
32KSR11.16830848
33PIM11.06217813
34MARK31.05512439
35WNK11.05024524
36MAP3K81.03544641
37STK101.02618899
38PRPF4B1.01220893
39TNIK1.00281903
40TLK10.96598101
41RIPK40.96264103
42MAP2K10.95190946
43RPS6KA50.92786600
44MKNK10.89872521
45PTK2B0.89172208
46TEC0.88637960
47BMX0.83796273
48MAP3K100.83747615
49BUB10.82937175
50STK30.82129313
51TAOK20.80111016
52NEK20.79729497
53TAF10.77710236
54PLK10.76972126
55DMPK0.76232199
56VRK10.72026122
57ADRBK10.70607233
58MAP3K110.68791909
59EIF2AK20.68775570
60SCYL20.66416700
61PRKCQ0.63257991
62BRAF0.62625765
63MAP2K40.60208564
64MAP3K60.59961847
65AKT30.57571573
66CHEK20.56775869
67CCNB10.54273052
68ATM0.51933699
69SYK0.46163960
70ILK0.45558433
71MAP3K50.43424490
72MAPK130.43191714
73BMPR20.42895809
74PRKAA20.41516649
75ATR0.41236937
76MINK10.40080053
77MAP3K20.39451728
78JAK20.38888711
79TAOK10.38315928
80KSR20.38167592
81AURKB0.36984133
82CHEK10.36684253
83SGK10.34917523
84TGFBR10.33010067
85SRPK10.32746201
86IRAK40.31579166
87NTRK30.26305216
88MAP3K30.26251937
89MATK0.25954501
90LRRK20.25569362
91CSNK2A10.23584055
92CAMK1D0.23570025
93RPS6KA40.21599155
94FGR0.20937033
95BTK0.20741816
96GRK50.20672523
97FRK0.20474586
98BCR0.19624086
99LYN0.19485742
100IRAK10.18700155

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.41720932
2Proteasome_Homo sapiens_hsa030502.82217113
3* Malaria_Homo sapiens_hsa051442.66983933
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.58285627
5Protein export_Homo sapiens_hsa030602.54619855
6Fanconi anemia pathway_Homo sapiens_hsa034602.33989091
7Mismatch repair_Homo sapiens_hsa034302.22807226
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22389794
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19511145
10One carbon pool by folate_Homo sapiens_hsa006702.13946045
11Homologous recombination_Homo sapiens_hsa034402.13493109
12Cell cycle_Homo sapiens_hsa041102.09894093
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05510703
14Pyruvate metabolism_Homo sapiens_hsa006201.95179516
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95119601
16DNA replication_Homo sapiens_hsa030301.87204742
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.85141363
18Steroid biosynthesis_Homo sapiens_hsa001001.85044451
19Nitrogen metabolism_Homo sapiens_hsa009101.82309484
20Parkinsons disease_Homo sapiens_hsa050121.69863384
21Spliceosome_Homo sapiens_hsa030401.64890652
22Oxidative phosphorylation_Homo sapiens_hsa001901.64660531
23Basal transcription factors_Homo sapiens_hsa030221.57122743
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49556434
25RNA transport_Homo sapiens_hsa030131.48859547
26Collecting duct acid secretion_Homo sapiens_hsa049661.46357786
27Mineral absorption_Homo sapiens_hsa049781.40445026
28Butanoate metabolism_Homo sapiens_hsa006501.38454464
29Systemic lupus erythematosus_Homo sapiens_hsa053221.34040004
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33972637
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32565143
32Propanoate metabolism_Homo sapiens_hsa006401.31478183
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31061333
34RNA degradation_Homo sapiens_hsa030181.29926079
35Nucleotide excision repair_Homo sapiens_hsa034201.28524338
36Regulation of autophagy_Homo sapiens_hsa041401.21405097
37Oocyte meiosis_Homo sapiens_hsa041141.17524930
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12215056
39p53 signaling pathway_Homo sapiens_hsa041151.10911941
40Hematopoietic cell lineage_Homo sapiens_hsa046401.10825138
41mRNA surveillance pathway_Homo sapiens_hsa030151.09027060
42Olfactory transduction_Homo sapiens_hsa047401.08569015
43African trypanosomiasis_Homo sapiens_hsa051431.07719407
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06313572
45Huntingtons disease_Homo sapiens_hsa050161.05641143
46Selenocompound metabolism_Homo sapiens_hsa004501.05522916
47Non-small cell lung cancer_Homo sapiens_hsa052231.01814438
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99055934
49Alcoholism_Homo sapiens_hsa050340.96276506
50Non-homologous end-joining_Homo sapiens_hsa034500.94452100
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94265796
52TGF-beta signaling pathway_Homo sapiens_hsa043500.92992997
53Pancreatic cancer_Homo sapiens_hsa052120.91423987
54ABC transporters_Homo sapiens_hsa020100.85146027
55Glutathione metabolism_Homo sapiens_hsa004800.82414712
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77891114
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76826500
58Fatty acid metabolism_Homo sapiens_hsa012120.73366717
59Viral carcinogenesis_Homo sapiens_hsa052030.72650672
60Acute myeloid leukemia_Homo sapiens_hsa052210.71998173
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67776123
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62620807
63Alzheimers disease_Homo sapiens_hsa050100.62474863
64HIF-1 signaling pathway_Homo sapiens_hsa040660.56337650
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54339076
66Base excision repair_Homo sapiens_hsa034100.54175003
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53325823
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.52983991
69Chronic myeloid leukemia_Homo sapiens_hsa052200.52542691
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52224926
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51161437
72FoxO signaling pathway_Homo sapiens_hsa040680.49202026
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.47210201
74Type II diabetes mellitus_Homo sapiens_hsa049300.46606882
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46105481
76Renal cell carcinoma_Homo sapiens_hsa052110.45813503
77Metabolic pathways_Homo sapiens_hsa011000.44686322
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.43441056
79Fatty acid elongation_Homo sapiens_hsa000620.42752933
80Inositol phosphate metabolism_Homo sapiens_hsa005620.42652772
81Melanoma_Homo sapiens_hsa052180.42497804
82Herpes simplex infection_Homo sapiens_hsa051680.39266688
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38817668
84Measles_Homo sapiens_hsa051620.37408492
85Carbon metabolism_Homo sapiens_hsa012000.36968934
86Epstein-Barr virus infection_Homo sapiens_hsa051690.36103230
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35820189
88Peroxisome_Homo sapiens_hsa041460.35570925
89Ribosome_Homo sapiens_hsa030100.35564985
90Purine metabolism_Homo sapiens_hsa002300.34812347
91Glioma_Homo sapiens_hsa052140.30350419
92Wnt signaling pathway_Homo sapiens_hsa043100.30202416
93Hepatitis B_Homo sapiens_hsa051610.29815858
94Small cell lung cancer_Homo sapiens_hsa052220.29628623
95B cell receptor signaling pathway_Homo sapiens_hsa046620.29050128
96Prostate cancer_Homo sapiens_hsa052150.27274348
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26907369
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.26085625
99mTOR signaling pathway_Homo sapiens_hsa041500.25846852
100RNA polymerase_Homo sapiens_hsa030200.25695250

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