GYPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)6.86918279
2protoporphyrinogen IX biosynthetic process (GO:0006782)6.47749980
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68878400
4negative regulation of cell killing (GO:0031342)5.68878400
5oxygen transport (GO:0015671)5.60069662
6heme biosynthetic process (GO:0006783)5.41904737
7porphyrin-containing compound biosynthetic process (GO:0006779)5.04854556
8positive regulation by symbiont of host defense response (GO:0052509)4.98408937
9modulation by symbiont of host defense response (GO:0052031)4.98408937
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.98408937
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.98408937
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.98408937
13modulation by symbiont of host immune response (GO:0052553)4.98408937
14ribosomal small subunit assembly (GO:0000028)4.90118844
15neutrophil activation involved in immune response (GO:0002283)4.73271234
16regulation of B cell receptor signaling pathway (GO:0050855)4.69835586
17gas transport (GO:0015669)4.67704115
18tetrapyrrole biosynthetic process (GO:0033014)4.56626560
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53938981
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.53938981
21erythrocyte maturation (GO:0043249)4.52339001
22detection of other organism (GO:0098543)4.49562254
23detection of bacterium (GO:0016045)4.45902791
24heme metabolic process (GO:0042168)4.40345209
25leukocyte aggregation (GO:0070486)4.16263479
26porphyrin-containing compound metabolic process (GO:0006778)4.09083933
27definitive hemopoiesis (GO:0060216)3.99754090
28antigen processing and presentation of endogenous antigen (GO:0019883)3.95828212
29response to peptidoglycan (GO:0032494)3.88684982
30positive regulation of granulocyte differentiation (GO:0030854)3.86340473
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85761404
32positive thymic T cell selection (GO:0045059)3.80761598
33cellular extravasation (GO:0045123)3.79708304
34macrophage activation involved in immune response (GO:0002281)3.79204128
35negative regulation of interleukin-12 production (GO:0032695)3.74903265
36respiratory burst (GO:0045730)3.72369915
37detection of external biotic stimulus (GO:0098581)3.72320515
38viral transcription (GO:0019083)3.72023940
39response to interleukin-15 (GO:0070672)3.71129730
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.65674988
41translational termination (GO:0006415)3.59139114
42microglial cell activation (GO:0001774)3.55006935
43negative T cell selection (GO:0043383)3.52433668
44DNA deamination (GO:0045006)3.51992140
45negative thymic T cell selection (GO:0045060)3.50317082
46B cell receptor signaling pathway (GO:0050853)3.46165046
47erythrocyte development (GO:0048821)3.45223665
48response to host immune response (GO:0052572)3.42225452
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42225452
50neutrophil activation (GO:0042119)3.40703970
51telomere maintenance via semi-conservative replication (GO:0032201)3.40693952
52positive regulation of gamma-delta T cell activation (GO:0046645)3.40487757
53positive T cell selection (GO:0043368)3.38207871
54regulation of mast cell degranulation (GO:0043304)3.36275904
55DNA strand elongation involved in DNA replication (GO:0006271)3.35411632
56negative regulation of leukocyte mediated immunity (GO:0002704)3.35287483
57positive regulation of B cell differentiation (GO:0045579)3.34241176
58neutrophil mediated immunity (GO:0002446)3.33990472
59cellular response to interleukin-15 (GO:0071350)3.33404243
60negative regulation of T cell mediated immunity (GO:0002710)3.31058621
61myeloid cell activation involved in immune response (GO:0002275)3.30133862
62regulation of interferon-beta biosynthetic process (GO:0045357)3.30021875
63translational elongation (GO:0006414)3.25486028
64megakaryocyte development (GO:0035855)3.25251585
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25043007
66purine-containing compound salvage (GO:0043101)3.24200189
67DNA strand elongation (GO:0022616)3.24143276
68embryonic hemopoiesis (GO:0035162)3.21344109
69detection of biotic stimulus (GO:0009595)3.20562048
70T cell migration (GO:0072678)3.19358656
71detection of molecule of bacterial origin (GO:0032490)3.17817343
72leukocyte degranulation (GO:0043299)3.17515390
73granulocyte activation (GO:0036230)3.17346598
74negative regulation of erythrocyte differentiation (GO:0045647)3.16404566
75positive regulation of natural killer cell differentiation (GO:0032825)3.15304757
76regulation of granulocyte differentiation (GO:0030852)3.14224051
77DNA unwinding involved in DNA replication (GO:0006268)3.13227912
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12416296
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.11748249
80DNA replication initiation (GO:0006270)3.11280725
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11014567
82response to host (GO:0075136)3.11014567
83response to host defenses (GO:0052200)3.11014567
84T cell selection (GO:0045058)3.10715133
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09734364
86antigen processing and presentation via MHC class Ib (GO:0002475)3.06948115
87thymic T cell selection (GO:0045061)3.06231052
88regulation of myeloid leukocyte mediated immunity (GO:0002886)3.04959623
89regulation of mast cell activation involved in immune response (GO:0033006)3.03269216
90macrophage activation (GO:0042116)3.03040156
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01988801
92response to interferon-beta (GO:0035456)3.01625223
93regulation of T cell tolerance induction (GO:0002664)3.01033783
94negative regulation of phagocytosis (GO:0050765)2.99038906
95protein targeting to ER (GO:0045047)2.98773003
96cotranslational protein targeting to membrane (GO:0006613)2.98662559
97regulation of erythrocyte differentiation (GO:0045646)2.98597566
98regulation of platelet aggregation (GO:0090330)2.96463751
99leukocyte migration involved in inflammatory response (GO:0002523)2.96085462
100regulation of alpha-beta T cell proliferation (GO:0046640)2.95492323
101negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95268537
102modulation by virus of host process (GO:0019054)2.95173833
103telomere maintenance via recombination (GO:0000722)2.94278255
104erythrocyte differentiation (GO:0030218)2.93458638
105necroptotic process (GO:0070266)2.88894872
106tolerance induction (GO:0002507)2.88569135
107regulation of leukocyte degranulation (GO:0043300)2.88493967
108myeloid cell development (GO:0061515)2.86168201
109myeloid leukocyte mediated immunity (GO:0002444)2.86101916
110response to muramyl dipeptide (GO:0032495)2.86015762
111establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84912020
112regulation of tolerance induction (GO:0002643)2.83433334
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83072294
114regulation of natural killer cell mediated immunity (GO:0002715)2.83072294
115protein localization to endoplasmic reticulum (GO:0070972)2.82095995
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81968949
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78552997
118negative regulation of innate immune response (GO:0045824)2.76718472
119hemoglobin metabolic process (GO:0020027)2.76628100
1203-UTR-mediated mRNA stabilization (GO:0070935)2.75967400
121viral life cycle (GO:0019058)2.73670364
122response to interferon-alpha (GO:0035455)2.73411146
123translational initiation (GO:0006413)2.73302129
124ribosomal small subunit biogenesis (GO:0042274)2.72313293
125response to type I interferon (GO:0034340)2.70622030
126tetrapyrrole metabolic process (GO:0033013)2.70247710
127IMP biosynthetic process (GO:0006188)2.67759549
128regulation of gamma-delta T cell differentiation (GO:0045586)2.66793991
129cellular response to type I interferon (GO:0071357)2.66439199
130type I interferon signaling pathway (GO:0060337)2.66439199
131IMP metabolic process (GO:0046040)2.63596032
132mitotic recombination (GO:0006312)2.63584790
133regulation of necroptotic process (GO:0060544)2.63578309
134cellular protein complex disassembly (GO:0043624)2.62377364
135Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60634376
136NIK/NF-kappaB signaling (GO:0038061)2.57928857
137maturation of SSU-rRNA (GO:0030490)2.57401107
138granulocyte differentiation (GO:0030851)2.57214923
139positive regulation of erythrocyte differentiation (GO:0045648)2.55497133
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55388160
141cellular response to zinc ion (GO:0071294)2.53076410
142formation of translation preinitiation complex (GO:0001731)2.52807046
143angiogenesis involved in wound healing (GO:0060055)2.50180069
144deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49731112
145telomere maintenance via telomere lengthening (GO:0010833)2.49279718
146defense response to protozoan (GO:0042832)2.49142962
147negative regulation of nitric oxide biosynthetic process (GO:0045019)2.47858560
148CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.47493503
149cellular response to interferon-beta (GO:0035458)2.47458215
150myeloid dendritic cell activation (GO:0001773)2.47102706
151negative regulation of viral entry into host cell (GO:0046597)2.46499267
152regulation of RIG-I signaling pathway (GO:0039535)2.46029512
153immunoglobulin mediated immune response (GO:0016064)2.45386191
154valine metabolic process (GO:0006573)2.45272842
155T cell homeostasis (GO:0043029)2.44300444
156platelet dense granule organization (GO:0060155)2.43384697
157regulation of B cell differentiation (GO:0045577)2.42809185
158regulation of natural killer cell differentiation (GO:0032823)2.42708902
159regulation of gamma-delta T cell activation (GO:0046643)2.39219191
160pigment biosynthetic process (GO:0046148)2.37955229
161protein complex disassembly (GO:0043241)2.34697626
162regulation of necrotic cell death (GO:0010939)2.34673942
163response to protozoan (GO:0001562)2.34366238
164regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.32810152
165negative regulation of viral genome replication (GO:0045071)2.31887837
166negative regulation of bone mineralization (GO:0030502)2.29961336
167natural killer cell differentiation (GO:0001779)2.28037109
168B cell mediated immunity (GO:0019724)2.27269377
169nuclear-transcribed mRNA catabolic process (GO:0000956)2.26425310
170lymph node development (GO:0048535)2.26409931
171positive regulation of protein import into nucleus, translocation (GO:0033160)2.23517868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.33027529
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25115048
3GATA1_22025678_ChIP-Seq_K562_Human3.16438252
4SCL_19346495_ChIP-Seq_HPC-7_Human3.05033057
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.03758158
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.51197292
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.50230369
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.49854555
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49150579
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48311464
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41259297
12TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.31519290
13SPI1_23127762_ChIP-Seq_K562_Human2.30478619
14RUNX_20019798_ChIP-Seq_JUKART_Human2.26672889
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20318314
16MYC_22102868_ChIP-Seq_BL_Human2.18060731
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17782137
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15564463
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.07151046
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05800382
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04866589
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02850283
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01603612
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99034064
25* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.96720217
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95522555
27* VDR_21846776_ChIP-Seq_THP-1_Human1.93695981
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93082887
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91944955
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91262604
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87810790
32KDM2B_26808549_Chip-Seq_DND41_Human1.87464708
33GATA1_22383799_ChIP-Seq_G1ME_Mouse1.87245437
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83325299
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.82524629
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.81451533
37* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80392752
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79716055
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78298573
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78074706
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.76213843
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.73130147
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69414133
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.67554402
45VDR_23849224_ChIP-Seq_CD4+_Human1.65015207
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64761195
47SPI1_23547873_ChIP-Seq_NB4_Human1.62762838
48* GATA2_19941826_ChIP-Seq_K562_Human1.61988849
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61027776
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58722879
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58718357
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58288018
53* MAF_26560356_Chip-Seq_TH1_Human1.58015915
54GATA3_27048872_Chip-Seq_THYMUS_Human1.55914680
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55617561
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55512658
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.53559294
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.52931326
59LXR_22292898_ChIP-Seq_THP-1_Human1.51877229
60FOXP3_21729870_ChIP-Seq_TREG_Human1.50832170
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50470182
62NCOR1_26117541_ChIP-Seq_K562_Human1.49785928
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48035206
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47049703
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46039307
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.45696958
67* MYB_26560356_Chip-Seq_TH2_Human1.45615039
68CIITA_25753668_ChIP-Seq_RAJI_Human1.45314472
69XRN2_22483619_ChIP-Seq_HELA_Human1.45226634
70* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44166238
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44033163
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43958029
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.42453945
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.42340576
75GATA1_19941826_ChIP-Seq_K562_Human1.40254467
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39759698
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39486428
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38151011
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37970604
80* VDR_24763502_ChIP-Seq_THP-1_Human1.36855936
81BCL6_27268052_Chip-Seq_Bcells_Human1.36785970
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35531856
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35233355
84* MYB_26560356_Chip-Seq_TH1_Human1.33439980
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32783947
86* UTX_26944678_Chip-Seq_JUKART_Human1.30845740
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30157859
88DCP1A_22483619_ChIP-Seq_HELA_Human1.29684323
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28976380
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28083959
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28058757
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27803379
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26998730
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.26763704
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26588847
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26456596
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26024384
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25788982
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25770029
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25713930
101* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25394236
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25096818
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24018745
104BCOR_27268052_Chip-Seq_Bcells_Human1.22419238
105NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21152185
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20608189
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20104291
108AR_21909140_ChIP-Seq_LNCAP_Human1.18852345
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.18157090
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.18113418
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18079458
112GABP_19822575_ChIP-Seq_HepG2_Human1.17543101
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16467408
114ELK1_19687146_ChIP-ChIP_HELA_Human1.15336814
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14731879
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14392280
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14089107
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13686006
119TCF7_22412390_ChIP-Seq_EML_Mouse1.13432075
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12975051
121* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11780865
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11440076
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10945551
124VDR_24787735_ChIP-Seq_THP-1_Human1.09568699
125PU_27001747_Chip-Seq_BMDM_Mouse1.08632194
126TFEB_21752829_ChIP-Seq_HELA_Human1.07547185
127SA1_27219007_Chip-Seq_ERYTHROID_Human1.05769678
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05675651
129CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04543272
130* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03824091
131* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03637703
132GATA3_26560356_Chip-Seq_TH2_Human1.02645436
133* MAF_26560356_Chip-Seq_TH2_Human1.02237769
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00827435
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99451848
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99157601
137SPI1_20517297_ChIP-Seq_HL60_Human0.98994253
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98583303
139P68_20966046_ChIP-Seq_HELA_Human0.98214628
140CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98105128
141THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97654459
142* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96896423
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95264057
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92045579
145CTCF_21964334_Chip-Seq_Bcells_Human0.86068220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.82977792
2MP0003656_abnormal_erythrocyte_physiolo4.43258333
3MP0002396_abnormal_hematopoietic_system3.32474876
4MP0005397_hematopoietic_system_phenotyp2.81806309
5MP0001545_abnormal_hematopoietic_system2.81806309
6MP0001835_abnormal_antigen_presentation2.75161683
7MP0000685_abnormal_immune_system2.67865214
8MP0006054_spinal_hemorrhage2.37885963
9MP0004808_abnormal_hematopoietic_stem2.32688538
10MP0009785_altered_susceptibility_to2.17901321
11MP0005671_abnormal_response_to2.11398768
12MP0002398_abnormal_bone_marrow2.05894369
13MP0008260_abnormal_autophagy2.05139342
14MP0003172_abnormal_lysosome_physiology1.93009719
15MP0005464_abnormal_platelet_physiology1.91523531
16MP0003724_increased_susceptibility_to1.85642995
17MP0003763_abnormal_thymus_physiology1.84017505
18MP0005025_abnormal_response_to1.83604001
19MP0001853_heart_inflammation1.81991986
20MP0002166_altered_tumor_susceptibility1.79486610
21MP0010094_abnormal_chromosome_stability1.78724807
22MP0001800_abnormal_humoral_immune1.78699948
23MP0003436_decreased_susceptibility_to1.76063873
24MP0000490_abnormal_crypts_of1.73832488
25MP0000689_abnormal_spleen_morphology1.73650784
26MP0005451_abnormal_body_composition1.71461172
27MP0002722_abnormal_immune_system1.69681975
28MP0003111_abnormal_nucleus_morphology1.68723592
29MP0005000_abnormal_immune_tolerance1.67535584
30MP0003077_abnormal_cell_cycle1.67329345
31MP0002452_abnormal_antigen_presenting1.65949877
32MP0010368_abnormal_lymphatic_system1.63832791
33MP0009333_abnormal_splenocyte_physiolog1.63527128
34MP0002429_abnormal_blood_cell1.62012930
35MP0002420_abnormal_adaptive_immunity1.61677856
36MP0002148_abnormal_hypersensitivity_rea1.61448410
37MP0001819_abnormal_immune_cell1.60210219
38MP0008057_abnormal_DNA_replication1.58918663
39MP0002723_abnormal_immune_serum1.57837466
40MP0005387_immune_system_phenotype1.56973010
41MP0001790_abnormal_immune_system1.56973010
42MP0008438_abnormal_cutaneous_collagen1.56059822
43MP0000716_abnormal_immune_system1.54646836
44MP0004381_abnormal_hair_follicle1.51775622
45MP0008007_abnormal_cellular_replicative1.49489214
46MP0003693_abnormal_embryo_hatching1.46814447
47MP0002419_abnormal_innate_immunity1.46806369
48MP0000465_gastrointestinal_hemorrhage1.36416841
49MP0010155_abnormal_intestine_physiology1.34697388
50MP0002405_respiratory_system_inflammati1.34529075
51MP0010352_gastrointestinal_tract_polyps1.34393749
52MP0003186_abnormal_redox_activity1.31543803
53MP0000343_altered_response_to1.31526902
54MP0002006_tumorigenesis1.29933184
55MP0005058_abnormal_lysosome_morphology1.28703293
56MP0000703_abnormal_thymus_morphology1.26306125
57MP0000015_abnormal_ear_pigmentation1.24356736
58MP0003279_aneurysm1.20900256
59MP0002132_abnormal_respiratory_system1.18548428
60MP0001879_abnormal_lymphatic_vessel1.18498524
61MP0002019_abnormal_tumor_incidence1.17352946
62MP0006036_abnormal_mitochondrial_physio1.16971495
63MP0009278_abnormal_bone_marrow1.16795419
64MP0004957_abnormal_blastocyst_morpholog1.16567797
65MP0001851_eye_inflammation1.14885516
66MP0003191_abnormal_cellular_cholesterol1.13213859
67MP0008058_abnormal_DNA_repair1.12713132
68MP0008469_abnormal_protein_level1.11750217
69MP0001845_abnormal_inflammatory_respons1.11619064
70MP0010307_abnormal_tumor_latency1.08668324
71MP0009764_decreased_sensitivity_to1.06256349
72MP0005310_abnormal_salivary_gland1.06142903
73MP0005075_abnormal_melanosome_morpholog1.03886383
74MP0002877_abnormal_melanocyte_morpholog1.03219193
75MP0004883_abnormal_blood_vessel1.02108967
76MP0001873_stomach_inflammation0.99686828
77MP0000858_altered_metastatic_potential0.99018357
78MP0008775_abnormal_heart_ventricle0.98209169
79MP0002998_abnormal_bone_remodeling0.96513046
80MP0003183_abnormal_peptide_metabolism0.96373865
81MP0000313_abnormal_cell_death0.94565219
82MP0009763_increased_sensitivity_to0.93499012
83MP0001663_abnormal_digestive_system0.93325569
84MP0004130_abnormal_muscle_cell0.92666855
85MP0001533_abnormal_skeleton_physiology0.92486073
86MP0005083_abnormal_biliary_tract0.92264197
87MP0002933_joint_inflammation0.90303786
88MP0005023_abnormal_wound_healing0.89045863
89MP0004947_skin_inflammation0.89034034
90MP0003300_gastrointestinal_ulcer0.88889877
91MP0003075_altered_response_to0.88758169
92MP0005503_abnormal_tendon_morphology0.88200869
93MP0003828_pulmonary_edema0.87842303
94MP0000749_muscle_degeneration0.87820089
95MP0005377_hearing/vestibular/ear_phenot0.87740259
96MP0003878_abnormal_ear_physiology0.87740259
97MP0003705_abnormal_hypodermis_morpholog0.86893301
98MP0004510_myositis0.86282140
99MP0000598_abnormal_liver_morphology0.84493842
100MP0005164_abnormal_response_to0.84001815
101MP0005174_abnormal_tail_pigmentation0.83690531
102MP0009840_abnormal_foam_cell0.83164554
103MP0003567_abnormal_fetal_cardiomyocyte0.82835216
104MP0006082_CNS_inflammation0.81970279
105MP0003221_abnormal_cardiomyocyte_apopto0.81611771
106MP0002095_abnormal_skin_pigmentation0.80838771
107MP0003866_abnormal_defecation0.80243510
108MP0003943_abnormal_hepatobiliary_system0.79846504
109MP0003806_abnormal_nucleotide_metabolis0.79367429
110MP0004185_abnormal_adipocyte_glucose0.78443007
111MP0003303_peritoneal_inflammation0.77097628
112MP0000350_abnormal_cell_proliferation0.76290636
113MP0001243_abnormal_dermal_layer0.76022231
114MP0002332_abnormal_exercise_endurance0.74815345
115MP0001915_intracranial_hemorrhage0.74537937
116MP0009765_abnormal_xenobiotic_induced0.73524412
117MP0005275_abnormal_skin_tensile0.72239910
118MP0005390_skeleton_phenotype0.71661991
119MP0009931_abnormal_skin_appearance0.71231577
120MP0005636_abnormal_mineral_homeostasis0.71152654
121MP0000609_abnormal_liver_physiology0.70237945
122MP0002277_abnormal_respiratory_mucosa0.69397016
123MP0005166_decreased_susceptibility_to0.69340297
124MP0003795_abnormal_bone_structure0.66605937
125MP0003448_altered_tumor_morphology0.65502087
126MP0000604_amyloidosis0.64214468
127MP0003045_fibrosis0.63840775
128MP0003690_abnormal_glial_cell0.63589749
129MP0008874_decreased_physiological_sensi0.62597103
130MP0005319_abnormal_enzyme/_coenzyme0.59940785
131MP0000249_abnormal_blood_vessel0.57672250
132MP0008004_abnormal_stomach_pH0.54091646

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.20669982
2Poikilocytosis (HP:0004447)5.49743868
3Abnormal number of erythroid precursors (HP:0012131)4.80221175
4Abnormality of cells of the erythroid lineage (HP:0012130)4.59350960
5Abnormality of macrophages (HP:0004311)4.46034645
6Stomatitis (HP:0010280)4.36297424
7Thrombocytosis (HP:0001894)4.12343420
8Orchitis (HP:0100796)4.08553443
9Obstructive lung disease (HP:0006536)4.07963562
10Chronic obstructive pulmonary disease (HP:0006510)4.07963562
11Recurrent gram-negative bacterial infections (HP:0005420)4.06460566
12Petechiae (HP:0000967)3.95273299
13Acanthocytosis (HP:0001927)3.94736999
14Abnormal hemoglobin (HP:0011902)3.80436970
15Retrobulbar optic neuritis (HP:0100654)3.69315398
16Optic neuritis (HP:0100653)3.69315398
17Elevated erythrocyte sedimentation rate (HP:0003565)3.61737164
18Meningitis (HP:0001287)3.61618064
19Reticulocytosis (HP:0001923)3.61606921
20Mediastinal lymphadenopathy (HP:0100721)3.49864624
21Prolonged bleeding time (HP:0003010)3.49026223
22Increased IgE level (HP:0003212)3.39172081
23Microcytic anemia (HP:0001935)3.34452211
24Aplastic anemia (HP:0001915)3.31198196
25Encephalitis (HP:0002383)3.23587483
26Abnormality of reticulocytes (HP:0004312)3.23348462
27Chronic otitis media (HP:0000389)3.23239132
28Polycythemia (HP:0001901)3.16230588
29IgM deficiency (HP:0002850)3.13759056
30Gingivitis (HP:0000230)3.02562673
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.00687816
32Epistaxis (HP:0000421)2.99275273
33Hyperbilirubinemia (HP:0002904)2.96790201
34Chronic mucocutaneous candidiasis (HP:0002728)2.94896260
35Recurrent cutaneous fungal infections (HP:0011370)2.94896260
36Keratoconjunctivitis sicca (HP:0001097)2.92870805
37T lymphocytopenia (HP:0005403)2.91948345
38Increased serum ferritin (HP:0003281)2.90554996
39Hypochromic microcytic anemia (HP:0004840)2.87346642
40Inflammation of the large intestine (HP:0002037)2.85796708
41Chest pain (HP:0100749)2.84939792
42Hypochromic anemia (HP:0001931)2.84786327
43Granulocytopenia (HP:0001913)2.82461115
44Abnormality of T cell number (HP:0011839)2.78457983
45Leukocytosis (HP:0001974)2.75511934
46Keratoconjunctivitis (HP:0001096)2.70503185
47Nausea (HP:0002018)2.70499819
48Cholelithiasis (HP:0001081)2.70016514
49Increased IgM level (HP:0003496)2.66651295
50Abnormality of the nasal mucosa (HP:0000433)2.63236691
51Autoimmune thrombocytopenia (HP:0001973)2.61382557
52Impaired platelet aggregation (HP:0003540)2.59573862
53Abnormal platelet function (HP:0011869)2.59573862
54Abnormality of T cell physiology (HP:0011840)2.59099546
55Osteomyelitis (HP:0002754)2.56490984
56Pallor (HP:0000980)2.56204583
57Reticulocytopenia (HP:0001896)2.55333424
58Myositis (HP:0100614)2.54908185
59Toxemia of pregnancy (HP:0100603)2.53347018
60Recurrent viral infections (HP:0004429)2.52824767
61Recurrent abscess formation (HP:0002722)2.51802282
62Abnormality of iron homeostasis (HP:0011031)2.49796350
63Recurrent bronchitis (HP:0002837)2.49196683
64Agammaglobulinemia (HP:0004432)2.48877487
65Nonimmune hydrops fetalis (HP:0001790)2.48561153
66Episodic fever (HP:0001954)2.46181231
67Pulmonary infiltrates (HP:0002113)2.42128547
68Slow saccadic eye movements (HP:0000514)2.41915578
69Protrusio acetabuli (HP:0003179)2.40763356
70Diaphragmatic weakness (HP:0009113)2.37618395
71Purpura (HP:0000979)2.36819704
72Autoimmune hemolytic anemia (HP:0001890)2.34175266
73Anorexia (HP:0002039)2.34033136
74Amaurosis fugax (HP:0100576)2.33739447
75Paralysis (HP:0003470)2.33092185
76Hemoptysis (HP:0002105)2.32191878
77Colitis (HP:0002583)2.32026544
78Hypergammaglobulinemia (HP:0010702)2.31080826
79Abnormal gallbladder morphology (HP:0012437)2.30893437
80Nasal polyposis (HP:0100582)2.29237306
81Eosinophilia (HP:0001880)2.26866436
82Birth length less than 3rd percentile (HP:0003561)2.26013512
83Hypertensive crisis (HP:0100735)2.25504156
84Arterial thrombosis (HP:0004420)2.23452825
85Vertebral compression fractures (HP:0002953)2.22098251
86Cellulitis (HP:0100658)2.21418046
87Sepsis (HP:0100806)2.20005444
88Abnormality of T cells (HP:0002843)2.19970606
89Cutaneous photosensitivity (HP:0000992)2.18499128
90Recurrent bacterial skin infections (HP:0005406)2.17248997
91Pulmonary embolism (HP:0002204)2.15713735
92Spontaneous hematomas (HP:0007420)2.12555502
93Abnormal platelet volume (HP:0011876)2.09954183
94Urticaria (HP:0001025)2.06660689
95Panhypogammaglobulinemia (HP:0003139)2.06306605
96Reduced antithrombin III activity (HP:0001976)2.05052161
97Gingival bleeding (HP:0000225)2.04712438
98Macrocytic anemia (HP:0001972)2.04051479
99Hepatosplenomegaly (HP:0001433)2.03909418
100Abnormality of transition element cation homeostasis (HP:0011030)2.03455419
101Acute myeloid leukemia (HP:0004808)2.02210797
102Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99581269
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99581269
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.99038736
105Abnormality of liposaccharide metabolism (HP:0010968)1.98562490
106Abnormality of glycosphingolipid metabolism (HP:0004343)1.98562490
107Abnormality of glycolipid metabolism (HP:0010969)1.98562490
108Short middle phalanx of the 5th finger (HP:0004220)1.98436614
109Neoplasm of head and neck (HP:0012288)1.98034769
110Esophageal neoplasm (HP:0100751)1.98034769
111Pustule (HP:0200039)1.94257709
112Abnormality of eosinophils (HP:0001879)1.91640309
113Skin rash (HP:0000988)1.91563758
114Abnormal gallbladder physiology (HP:0012438)1.89871314
115Cholecystitis (HP:0001082)1.89871314
116Abnormality of the pleura (HP:0002103)1.89519023
117Exertional dyspnea (HP:0002875)1.89080382
118Lymphoma (HP:0002665)1.88382123
119Skin ulcer (HP:0200042)1.88054376
120Gastrointestinal infarctions (HP:0005244)1.87982072
121Hematochezia (HP:0002573)1.87240935
122Peritonitis (HP:0002586)1.87075551
123Splenomegaly (HP:0001744)1.86577252
124Abnormality of the pericardium (HP:0001697)1.85859605
125Severe combined immunodeficiency (HP:0004430)1.85287414
126Increased mean platelet volume (HP:0011877)1.84096811
127Verrucae (HP:0200043)1.83781509
128Papilloma (HP:0012740)1.83781509
129Fatigue (HP:0012378)1.83376485
130Recurrent fungal infections (HP:0002841)1.81901055
131Increased muscle lipid content (HP:0009058)1.80920841
132Eczematoid dermatitis (HP:0000976)1.78532744
133IgG deficiency (HP:0004315)1.78033395
134Hepatic necrosis (HP:0002605)1.77745969
135Vasculitis (HP:0002633)1.77464642
136Hypertriglyceridemia (HP:0002155)1.77125039
137Beaking of vertebral bodies (HP:0004568)1.76953120
138Thrombophlebitis (HP:0004418)1.75684368
139Myelodysplasia (HP:0002863)1.74054876
140Pancytopenia (HP:0001876)1.73510800
141B lymphocytopenia (HP:0010976)1.72360126
142Abnormality of B cell number (HP:0010975)1.72360126
143Broad palm (HP:0001169)1.70477552
144Gastrointestinal stroma tumor (HP:0100723)1.69889032
145Reduced subcutaneous adipose tissue (HP:0003758)1.68163833
146Abnormality of the prostate (HP:0008775)1.68035721
147Rhabdomyolysis (HP:0003201)1.67558936
148Abnormality of the fingertips (HP:0001211)1.67037887
149Recurrent skin infections (HP:0001581)1.66869588
150Multiple enchondromatosis (HP:0005701)1.66580739
151Ankle contracture (HP:0006466)1.65814653
152Hepatocellular carcinoma (HP:0001402)1.65628084
153Gastrointestinal inflammation (HP:0004386)1.63188062
154Generalized aminoaciduria (HP:0002909)1.61476516
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.61319848
156Neutropenia (HP:0001875)1.60701308
157Increased intramyocellular lipid droplets (HP:0012240)1.60411261
158Lymphopenia (HP:0001888)1.60384706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.13831599
2EIF2AK12.97755592
3MAP4K12.92328341
4NME22.85470268
5PRPF4B2.69309891
6KIT2.58273731
7FES2.51672862
8JAK32.32115190
9FLT32.28734096
10TNK22.27042240
11EEF2K2.19026853
12MAP2K32.17749321
13KDR2.12823335
14TAOK12.09810042
15CSK2.09071102
16CDC72.08554803
17MAP3K32.06995006
18TYK22.02386532
19TIE11.99945084
20ACVR1B1.99751925
21TGFBR11.91804369
22TBK11.90696344
23PIM21.82349147
24TGFBR21.77339333
25ZAP701.72271614
26PKN21.71386356
27TRIB31.65934620
28BTK1.61774919
29TEC1.61019501
30STK41.58741006
31ERN11.57814044
32FGR1.57542512
33WEE11.51668601
34IKBKE1.45615484
35MAP3K11.44914362
36RPS6KA41.43894654
37VRK11.40142822
38EPHB11.39500985
39PIM11.38627557
40TESK21.38284870
41STK101.37851209
42IKBKB1.33990692
43BUB11.33210751
44MARK31.32888338
45TLK11.32054730
46SCYL21.30935693
47IRAK41.27928627
48NEK21.27482046
49SYK1.21538431
50BCKDK1.20444764
51MAP3K101.20120700
52LRRK21.18601344
53NEK91.13426665
54MAP3K141.11529730
55MAP3K111.10776534
56TXK1.10036247
57MAPKAPK31.07941666
58CSF1R1.05685602
59KSR21.05404086
60BLK1.05284023
61DYRK31.05061368
62STK161.02792919
63RPS6KB21.00064642
64BRSK20.99826958
65MAP3K130.98083029
66EIF2AK30.95276919
67SIK30.94200112
68PTK2B0.93263241
69SMG10.92176788
70MARK20.89042845
71MAP3K80.88773436
72TTN0.87558715
73ATR0.87021720
74MYLK0.86097836
75STK240.85431738
76CDK40.84299615
77LYN0.84134758
78MAPK110.81985037
79CDK190.80884327
80TRPM70.79766123
81JAK10.79434302
82MAPK120.78621212
83HIPK20.77196621
84PDK10.76480531
85AURKB0.76424439
86LCK0.75841609
87JAK20.74887006
88PRKD20.74502751
89PTK60.72891453
90MATK0.71691640
91SIK20.70612270
92ZAK0.70552428
93MAPKAPK50.70507144
94BRSK10.70415544
95CHUK0.67387542
96NEK10.66568138
97CDK70.65937904
98CCNB10.65265355
99RPS6KA50.65053487
100ILK0.64992190
101MAP3K70.63732839
102TAOK30.62595638
103RAF10.62193083
104CLK10.61211857
105PDPK10.61095352
106PRKCQ0.60652657
107BMPR20.60045309
108BMX0.59895410
109EIF2AK20.59265145
110GRK50.57700554
111FGFR40.57169035
112MAP2K60.55858012
113MAPKAPK20.55590753
114MAP3K60.54800807
115CDK80.54016479
116ABL20.53045230
117FYN0.52149301
118DYRK1B0.52035813
119MKNK10.50353838
120MAP3K50.49660639
121GRK60.48213590
122TAOK20.47485009
123HCK0.46494930
124CDK60.46364979
125STK110.44330558
126IRAK10.43947608
127YES10.43437075
128RPS6KA60.42760160
129PASK0.42643443
130ICK0.41805160
131NLK0.41070767
132SIK10.40766952
133PLK10.39455347
134MAPK40.39247680
135ITK0.38633573
136GRK70.36471062
137MAP2K40.36271602
138PAK40.36074904
139STK30.35845227
140MAPK70.34667605
141SGK30.34502563
142PIK3CG0.33925796
143MAP3K20.33549582
144RET0.32337671
145RPS6KL10.32242147
146RPS6KC10.32242147
147CDC42BPA0.30397971

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.13236554
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.57656831
3Ribosome_Homo sapiens_hsa030103.11638395
4Mismatch repair_Homo sapiens_hsa034302.45601262
5Base excision repair_Homo sapiens_hsa034102.37240152
6Autoimmune thyroid disease_Homo sapiens_hsa053202.17759322
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08066685
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03070370
9Systemic lupus erythematosus_Homo sapiens_hsa053221.95229100
10Primary immunodeficiency_Homo sapiens_hsa053401.80513685
11Herpes simplex infection_Homo sapiens_hsa051681.75461040
12Measles_Homo sapiens_hsa051621.73326910
13Nucleotide excision repair_Homo sapiens_hsa034201.71495795
14Leishmaniasis_Homo sapiens_hsa051401.71068014
15Cell cycle_Homo sapiens_hsa041101.70552458
16Homologous recombination_Homo sapiens_hsa034401.69389514
17African trypanosomiasis_Homo sapiens_hsa051431.66745333
18Pyrimidine metabolism_Homo sapiens_hsa002401.66489422
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65415147
20Proteasome_Homo sapiens_hsa030501.63516103
21Caffeine metabolism_Homo sapiens_hsa002321.61848005
22Hematopoietic cell lineage_Homo sapiens_hsa046401.59207244
23Non-small cell lung cancer_Homo sapiens_hsa052231.54762645
24Type I diabetes mellitus_Homo sapiens_hsa049401.54571701
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54557242
26Spliceosome_Homo sapiens_hsa030401.52806098
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.50742460
28One carbon pool by folate_Homo sapiens_hsa006701.50324719
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.49959815
30Chemokine signaling pathway_Homo sapiens_hsa040621.47560851
31Antigen processing and presentation_Homo sapiens_hsa046121.43653733
32p53 signaling pathway_Homo sapiens_hsa041151.31759521
33Legionellosis_Homo sapiens_hsa051341.30633179
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30397681
35Sulfur relay system_Homo sapiens_hsa041221.25273562
36Non-homologous end-joining_Homo sapiens_hsa034501.23157435
37Phagosome_Homo sapiens_hsa041451.22456854
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.18076053
39RNA polymerase_Homo sapiens_hsa030201.17432101
40Allograft rejection_Homo sapiens_hsa053301.15934124
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15286707
42Apoptosis_Homo sapiens_hsa042101.14092144
43* Malaria_Homo sapiens_hsa051441.13678493
44Viral carcinogenesis_Homo sapiens_hsa052031.09173588
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08709680
46RNA transport_Homo sapiens_hsa030131.07112258
47Toxoplasmosis_Homo sapiens_hsa051451.06916028
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06667375
49VEGF signaling pathway_Homo sapiens_hsa043701.05377412
50RNA degradation_Homo sapiens_hsa030181.03912480
51Influenza A_Homo sapiens_hsa051641.03674542
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00389341
53B cell receptor signaling pathway_Homo sapiens_hsa046620.99571032
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99145384
55Viral myocarditis_Homo sapiens_hsa054160.98728375
56Hepatitis B_Homo sapiens_hsa051610.96811581
57Small cell lung cancer_Homo sapiens_hsa052220.95262366
58Acute myeloid leukemia_Homo sapiens_hsa052210.95103509
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94415243
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93320518
61Osteoclast differentiation_Homo sapiens_hsa043800.92478989
62Rheumatoid arthritis_Homo sapiens_hsa053230.92294806
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90655111
64Salmonella infection_Homo sapiens_hsa051320.90539174
65Chronic myeloid leukemia_Homo sapiens_hsa052200.89312279
66Pentose phosphate pathway_Homo sapiens_hsa000300.88398082
67Platelet activation_Homo sapiens_hsa046110.88314525
68Shigellosis_Homo sapiens_hsa051310.87114701
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86825608
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84404048
71Epstein-Barr virus infection_Homo sapiens_hsa051690.84396549
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83587997
73TNF signaling pathway_Homo sapiens_hsa046680.80742316
74Fanconi anemia pathway_Homo sapiens_hsa034600.80183667
75Folate biosynthesis_Homo sapiens_hsa007900.78712551
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.78048519
77Prolactin signaling pathway_Homo sapiens_hsa049170.76995121
78Pertussis_Homo sapiens_hsa051330.75867927
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74477976
80FoxO signaling pathway_Homo sapiens_hsa040680.73372100
81Renal cell carcinoma_Homo sapiens_hsa052110.72490077
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.72181349
83HTLV-I infection_Homo sapiens_hsa051660.72173551
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71988513
85Purine metabolism_Homo sapiens_hsa002300.70926724
86Endocytosis_Homo sapiens_hsa041440.70894625
87Lysosome_Homo sapiens_hsa041420.67331891
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65908976
89mTOR signaling pathway_Homo sapiens_hsa041500.63811582
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.63535265
91Selenocompound metabolism_Homo sapiens_hsa004500.63122470
92Thyroid cancer_Homo sapiens_hsa052160.62104960
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.61567111
94Endometrial cancer_Homo sapiens_hsa052130.59744574
95Asthma_Homo sapiens_hsa053100.59122348
96Regulation of autophagy_Homo sapiens_hsa041400.58774585
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58543101
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58500610
99Carbon metabolism_Homo sapiens_hsa012000.57513202
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.55621888
101Fatty acid degradation_Homo sapiens_hsa000710.55175418
102HIF-1 signaling pathway_Homo sapiens_hsa040660.54934775
103N-Glycan biosynthesis_Homo sapiens_hsa005100.54490270
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54320472
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54040888
106Notch signaling pathway_Homo sapiens_hsa043300.53680292
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53533375
108ABC transporters_Homo sapiens_hsa020100.53276739
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.52490148
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52153080
111Colorectal cancer_Homo sapiens_hsa052100.50861797
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.50529835
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49497562
114Tuberculosis_Homo sapiens_hsa051520.49234656
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48843253
116Choline metabolism in cancer_Homo sapiens_hsa052310.48736693
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.47210079
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47096529
119Insulin resistance_Homo sapiens_hsa049310.45735603
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45207427
121Amoebiasis_Homo sapiens_hsa051460.44917570
122Pancreatic cancer_Homo sapiens_hsa052120.44324668
123Graft-versus-host disease_Homo sapiens_hsa053320.43296322
124Galactose metabolism_Homo sapiens_hsa000520.43254421
125Hepatitis C_Homo sapiens_hsa051600.42967439
126Staphylococcus aureus infection_Homo sapiens_hsa051500.42595136
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42576191
128Biosynthesis of amino acids_Homo sapiens_hsa012300.42139537
129T cell receptor signaling pathway_Homo sapiens_hsa046600.41600877
130Alcoholism_Homo sapiens_hsa050340.41464026
131Inositol phosphate metabolism_Homo sapiens_hsa005620.40932016
132Collecting duct acid secretion_Homo sapiens_hsa049660.40811687
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.39994022
134Bladder cancer_Homo sapiens_hsa052190.39487160
135MAPK signaling pathway_Homo sapiens_hsa040100.39454224
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39229926
137Other glycan degradation_Homo sapiens_hsa005110.38126153
138Protein export_Homo sapiens_hsa030600.37677028
139Propanoate metabolism_Homo sapiens_hsa006400.36482669
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36480575
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36364807
142Glioma_Homo sapiens_hsa052140.34567410
143Insulin signaling pathway_Homo sapiens_hsa049100.33861952
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32806665
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31941657
146GnRH signaling pathway_Homo sapiens_hsa049120.31800503

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