GZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.45571780
2L-phenylalanine catabolic process (GO:0006559)6.45571780
3L-phenylalanine metabolic process (GO:0006558)6.13439304
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.13439304
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91234056
6alpha-linolenic acid metabolic process (GO:0036109)5.88038964
7bile acid biosynthetic process (GO:0006699)5.67392845
8aromatic amino acid family catabolic process (GO:0009074)5.66829948
9urea metabolic process (GO:0019627)5.61985096
10urea cycle (GO:0000050)5.61985096
11nuclear pore complex assembly (GO:0051292)5.55429973
12glyoxylate metabolic process (GO:0046487)5.21190908
13cysteine metabolic process (GO:0006534)5.17187753
14negative regulation of fibrinolysis (GO:0051918)5.17103041
15high-density lipoprotein particle remodeling (GO:0034375)5.15003315
16kynurenine metabolic process (GO:0070189)5.10056999
17nitrogen cycle metabolic process (GO:0071941)5.01982773
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.99826019
19complement activation, alternative pathway (GO:0006957)4.98639861
20sulfur amino acid catabolic process (GO:0000098)4.95898236
21nuclear pore organization (GO:0006999)4.94708375
22tryptophan catabolic process (GO:0006569)4.94546733
23indole-containing compound catabolic process (GO:0042436)4.94546733
24indolalkylamine catabolic process (GO:0046218)4.94546733
25protein carboxylation (GO:0018214)4.88354054
26peptidyl-glutamic acid carboxylation (GO:0017187)4.88354054
27lysine metabolic process (GO:0006553)4.82793339
28lysine catabolic process (GO:0006554)4.82793339
29regulation of protein activation cascade (GO:2000257)4.81634119
30bile acid metabolic process (GO:0008206)4.79241001
31regulation of NFAT protein import into nucleus (GO:0051532)4.77783654
32pore complex assembly (GO:0046931)4.75315722
33regulation of fibrinolysis (GO:0051917)4.75069712
34tryptophan metabolic process (GO:0006568)4.74407541
35serine family amino acid catabolic process (GO:0009071)4.69828080
36regulation of triglyceride catabolic process (GO:0010896)4.56993239
37homocysteine metabolic process (GO:0050667)4.55765489
38reverse cholesterol transport (GO:0043691)4.54233589
39regulation of complement activation (GO:0030449)4.48764112
40protein-lipid complex remodeling (GO:0034368)4.46677531
41macromolecular complex remodeling (GO:0034367)4.46677531
42plasma lipoprotein particle remodeling (GO:0034369)4.46677531
43amino-acid betaine metabolic process (GO:0006577)4.45783144
44tyrosine metabolic process (GO:0006570)4.36810972
45protein localization to endosome (GO:0036010)4.35980552
46positive regulation of fatty acid beta-oxidation (GO:0032000)4.34501118
47triglyceride homeostasis (GO:0070328)4.33772479
48acylglycerol homeostasis (GO:0055090)4.33772479
49plasma lipoprotein particle clearance (GO:0034381)4.33651522
50response to muramyl dipeptide (GO:0032495)4.28923018
51dicarboxylic acid biosynthetic process (GO:0043650)4.26600313
52mitotic sister chromatid cohesion (GO:0007064)4.21297800
53alpha-amino acid catabolic process (GO:1901606)4.18888204
54cellular ketone body metabolic process (GO:0046950)4.15967595
55regulation of cholesterol esterification (GO:0010872)4.09192698
56positive regulation of lipid catabolic process (GO:0050996)4.08612421
57ethanol oxidation (GO:0006069)4.05635699
58aromatic amino acid family metabolic process (GO:0009072)4.04021782
59negative regulation of sterol transport (GO:0032372)4.03595138
60negative regulation of cholesterol transport (GO:0032375)4.03595138
61phospholipid efflux (GO:0033700)4.03364545
62phospholipid homeostasis (GO:0055091)4.01892397
63glutamate metabolic process (GO:0006536)3.98934830
64coenzyme catabolic process (GO:0009109)3.96558694
65glycine metabolic process (GO:0006544)3.91379980
66cholesterol efflux (GO:0033344)3.89955286
672-oxoglutarate metabolic process (GO:0006103)3.88653039
68cellular amino acid catabolic process (GO:0009063)3.87142479
69regulation of RNA export from nucleus (GO:0046831)3.86736837
70spliceosomal tri-snRNP complex assembly (GO:0000244)3.82970365
71plasma lipoprotein particle assembly (GO:0034377)3.76043801
72acetyl-CoA metabolic process (GO:0006084)3.74908303
73cellular glucuronidation (GO:0052695)3.74726327
74drug catabolic process (GO:0042737)3.73894030
75regulation of cholesterol homeostasis (GO:2000188)3.73795996
76cellular modified amino acid catabolic process (GO:0042219)3.73624378
77regulation of fatty acid beta-oxidation (GO:0031998)3.71708528
78serine family amino acid metabolic process (GO:0009069)3.70089066
79short-chain fatty acid metabolic process (GO:0046459)3.68883697
80regulation of nucleobase-containing compound transport (GO:0032239)3.68757993
81fatty acid transmembrane transport (GO:1902001)3.67438497
82ketone body metabolic process (GO:1902224)3.66660060
83response to peptidoglycan (GO:0032494)3.66640816
84imidazole-containing compound metabolic process (GO:0052803)3.63712666
85bile acid and bile salt transport (GO:0015721)3.63397513
86very-low-density lipoprotein particle assembly (GO:0034379)3.61726235
87positive regulation of fatty acid oxidation (GO:0046321)3.61376175
88valine metabolic process (GO:0006573)3.56759646
89aspartate family amino acid catabolic process (GO:0009068)3.53757156
90fatty acid beta-oxidation (GO:0006635)3.53466286
91monocarboxylic acid catabolic process (GO:0072329)3.51736228
92negative regulation of lipase activity (GO:0060192)3.51357601
93organic acid catabolic process (GO:0016054)3.50876831
94carboxylic acid catabolic process (GO:0046395)3.50876831
95indolalkylamine metabolic process (GO:0006586)3.50213475
96fatty acid oxidation (GO:0019395)3.49978491
97protein-lipid complex assembly (GO:0065005)3.48422131
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.48277968
99embryonic process involved in female pregnancy (GO:0060136)3.46947533
100plasma lipoprotein particle organization (GO:0071827)3.46609408
101low-density lipoprotein particle remodeling (GO:0034374)3.44736262
102fibrinolysis (GO:0042730)3.44645235
103benzene-containing compound metabolic process (GO:0042537)3.44242015
104lipid oxidation (GO:0034440)3.42931657
105histone H3-K36 demethylation (GO:0070544)3.42525401
106arginine metabolic process (GO:0006525)3.37385746
107serine family amino acid biosynthetic process (GO:0009070)3.36880252
108cholesterol homeostasis (GO:0042632)3.33333643
109lipoprotein metabolic process (GO:0042157)3.32760845
110protein-lipid complex subunit organization (GO:0071825)3.32470012
111cellular extravasation (GO:0045123)3.32226675
112sterol homeostasis (GO:0055092)3.31308203
113fatty acid catabolic process (GO:0009062)3.30672306
114carnitine metabolic process (GO:0009437)3.28513532
115cellular response to arsenic-containing substance (GO:0071243)3.25550110
116mitotic chromosome condensation (GO:0007076)3.24346443
117positive regulation of cell cycle checkpoint (GO:1901978)3.21321435
118negative regulation of erythrocyte differentiation (GO:0045647)3.20555478
119RNA stabilization (GO:0043489)3.08300076
120mRNA stabilization (GO:0048255)3.08300076
1213-UTR-mediated mRNA stabilization (GO:0070935)2.99054655
122dosage compensation (GO:0007549)2.98202228
123regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.97643057
124negative regulation of inclusion body assembly (GO:0090084)2.94915531
125regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.94475329
126histone demethylation (GO:0016577)2.84666272
127histone lysine demethylation (GO:0070076)2.83388860
128peptidyl-lysine dimethylation (GO:0018027)2.77538421
129DNA synthesis involved in DNA repair (GO:0000731)2.75716082
130negative regulation of myotube differentiation (GO:0010832)2.74420221
131positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.71630877
132regulation of histone H3-K27 methylation (GO:0061085)2.69425218
133peptidyl-threonine dephosphorylation (GO:0035970)2.66387397
134response to laminar fluid shear stress (GO:0034616)2.65444226
135negative regulation of histone methylation (GO:0031061)2.61046918
136peptidyl-threonine phosphorylation (GO:0018107)2.60619834
137positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60223078
138activation of Rac GTPase activity (GO:0032863)2.59898763
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57417941
140ER overload response (GO:0006983)2.56963119
141protein localization to chromosome, centromeric region (GO:0071459)2.56818696
142N-terminal protein amino acid acetylation (GO:0006474)2.56531431
143coronary vasculature morphogenesis (GO:0060977)2.55239975
144germinal center formation (GO:0002467)2.53827202
145cellular response to nerve growth factor stimulus (GO:1990090)2.50519141
146response to nerve growth factor (GO:1990089)2.50519141
147protein dealkylation (GO:0008214)2.48336448
148protein demethylation (GO:0006482)2.48336448
149sister chromatid cohesion (GO:0007062)2.47768979
150peptidyl-threonine modification (GO:0018210)2.45645016
151histone H2B ubiquitination (GO:0033523)2.43717525
152embryonic camera-type eye morphogenesis (GO:0048596)2.42628833
153regulation of macrophage cytokine production (GO:0010935)2.42312849
154G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.42180195
155positive regulation of macrophage cytokine production (GO:0060907)2.41619242
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41103615
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.41103615
158modulation by symbiont of host immune response (GO:0052553)2.41103615
159positive regulation by symbiont of host defense response (GO:0052509)2.41103615
160modulation by symbiont of host defense response (GO:0052031)2.41103615
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41103615
162definitive hemopoiesis (GO:0060216)2.40824018
163stress fiber assembly (GO:0043149)2.39625734
164regulation of leukocyte degranulation (GO:0043300)2.36813119
165detection of molecule of bacterial origin (GO:0032490)2.36809722
166DNA unwinding involved in DNA replication (GO:0006268)2.36499242
167histone H3-K9 demethylation (GO:0033169)2.35368653
168histone H2A monoubiquitination (GO:0035518)2.35188575
169heart valve formation (GO:0003188)2.34483307
170lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33944723
171negative regulation of type 2 immune response (GO:0002829)2.31969592
172DNA topological change (GO:0006265)2.30220976
173mitotic metaphase plate congression (GO:0007080)2.29702853
174protein export from nucleus (GO:0006611)2.28845979
175establishment of chromosome localization (GO:0051303)2.28745390
176regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28654518
177cellular protein complex localization (GO:0034629)2.28328093
178regulation of ARF protein signal transduction (GO:0032012)2.28009737
179histone monoubiquitination (GO:0010390)2.27943698
180positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25685098
181positive regulation of macroautophagy (GO:0016239)2.25107899
182regulation of histone H3-K9 methylation (GO:0051570)2.24459668
183histone H4 deacetylation (GO:0070933)2.22826041
184positive regulation of protein export from nucleus (GO:0046827)2.21950561
185negative regulation of DNA repair (GO:0045738)2.21827426
186positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.21551339
187adenosine receptor signaling pathway (GO:0001973)2.20934642
188mRNA transcription (GO:0009299)2.19082886
189COPI coating of Golgi vesicle (GO:0048205)2.18229666
190Golgi transport vesicle coating (GO:0048200)2.18229666
191insulin-like growth factor receptor signaling pathway (GO:0048009)2.18048170
192regulation of mRNA stability (GO:0043488)2.17364976
193negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17099986
194cell-substrate adherens junction assembly (GO:0007045)2.16955377
195focal adhesion assembly (GO:0048041)2.16955377
196negative regulation of NF-kappaB import into nucleus (GO:0042347)2.14985074
197regulation of T-helper 2 cell differentiation (GO:0045628)2.14706408
198N-terminal protein amino acid modification (GO:0031365)2.14658713
199negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.14582119
200macrophage activation involved in immune response (GO:0002281)2.14136806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.40494929
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.30302270
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.07751694
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.73019194
5EGR1_19374776_ChIP-ChIP_THP-1_Human5.68797822
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.35228466
7E2F7_22180533_ChIP-Seq_HELA_Human4.92448074
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63778164
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94113160
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.89434949
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.76816302
12MYC_22102868_ChIP-Seq_BL_Human3.37304742
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.18496433
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84263248
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.63169461
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57825135
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.50207317
18VDR_21846776_ChIP-Seq_THP-1_Human2.45693089
19* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44313570
20TCF7_22412390_ChIP-Seq_EML_Mouse2.32241332
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.29163178
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27818891
23CLOCK_20551151_ChIP-Seq_293T_Human2.19501652
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14881953
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09850780
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09146866
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08122102
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04273309
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3903816
30TFEB_21752829_ChIP-Seq_HELA_Human1.99655744
31CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.95214090
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92265303
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91036454
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.88723505
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.86481354
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.85645722
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.84127569
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83964786
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.81906205
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80533235
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.78495775
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77348187
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76801710
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75521765
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71939987
46VDR_24763502_ChIP-Seq_THP-1_Human1.71374169
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.68261409
48* KDM2B_26808549_Chip-Seq_DND41_Human1.65977417
49* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65421942
50* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63706320
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62040753
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61921397
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61267998
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59648225
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56402287
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54309911
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53526152
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49307622
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46507893
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46507893
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46507893
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.46462865
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44224658
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40740778
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.39750175
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39298411
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37908753
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36714653
69KDM2B_26808549_Chip-Seq_K562_Human1.33509782
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33377349
71* MAF_26560356_Chip-Seq_TH1_Human1.31366002
72* CHD1_26751641_Chip-Seq_LNCaP_Human1.30856559
73PU_27001747_Chip-Seq_BMDM_Mouse1.30420598
74SCL_19346495_ChIP-Seq_HPC-7_Human1.30021633
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.27383811
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26700349
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24010716
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.22057033
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18572264
80* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16456471
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15566219
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.15254903
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14446880
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13817981
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.13696180
86HTT_18923047_ChIP-ChIP_STHdh_Human1.13296593
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12457436
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.12369183
89SPI1_23547873_ChIP-Seq_NB4_Human1.12106669
90* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11572950
91CIITA_25753668_ChIP-Seq_RAJI_Human1.11265091
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.09974883
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.09797875
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09616579
95* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09404176
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08741279
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08675993
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06646227
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05206264
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.05121995
101* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04709229
102GATA1_22025678_ChIP-Seq_K562_Human1.03756950
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03754598
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01596403
105NCOR1_26117541_ChIP-Seq_K562_Human1.01440827
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00421025
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99392973
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98669552
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98669552
110* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95631089
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95139633
112* ATF3_27146783_Chip-Seq_COLON_Human0.95139054
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94985573
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.94107489
115AR_21909140_ChIP-Seq_LNCAP_Human0.94099884
116SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93458483
117* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92069138
118* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92069138
119ZNF263_19887448_ChIP-Seq_K562_Human0.92051872
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90506572
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90156370
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90142440
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.88422300
124BCAT_22108803_ChIP-Seq_LS180_Human0.88041353
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87612684
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85985643
127GATA4_25053715_ChIP-Seq_YYC3_Human0.85707465
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85519183
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84330530
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81960873
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80104863
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79932569
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79713470
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.76484682
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76481991
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75702549
137* TBX20_22080862_ChIP-Seq_HEART_Mouse0.75495492
138* TBX20_22328084_ChIP-Seq_HEART_Mouse0.75495492
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.74761518
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74221355
141THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73992170
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73848018
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72706926
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72666084
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.68918610
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68417655
147* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67953138
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.67803925
149CDX2_22108803_ChIP-Seq_LS180_Human0.67185995
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.66562032
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.63656417
152CBP_21632823_ChIP-Seq_H3396_Human0.61335166
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.57953705
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.56252635
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.56189585
156SOX2_21211035_ChIP-Seq_LN229_Gbm0.56155488
157GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.55598086
158ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.55588079
159FOXM1_26456572_ChIP-Seq_MCF-7_Human0.55370956
160* GATA6_25053715_ChIP-Seq_YYC3_Human0.54722697
161RARA_24833708_ChIP-Seq_LIVER_Mouse0.54568523
162SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.54434735
163ELK4_26923725_Chip-Seq_MESODERM_Mouse0.53896533
164IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53336346
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.52616381
166GATA3_24758297_ChIP-Seq_MCF-7_Human0.52000848
167KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.51925114
168STAT1_17558387_ChIP-Seq_HELA_Human0.51760297
169PIAS1_25552417_ChIP-Seq_VCAP_Human0.50920288
170CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50651835
171RXR_22108803_ChIP-Seq_LS180_Human0.50299567
172TP63_23658742_ChIP-Seq_EP156T_Human0.49394915
173DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.49257249
174CBP_20019798_ChIP-Seq_JUKART_Human0.48250805
175IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.48250805
176TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.47609955
177TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.46842202
178SMAD4_21799915_ChIP-Seq_A2780_Human0.46790609
179TCF4_22108803_ChIP-Seq_LS180_Human0.44714548
180KAP1_22055183_ChIP-Seq_ESCs_Mouse0.44696798
181FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.44516362
182TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.43856221
183SMAD4_21741376_ChIP-Seq_EPCs_Human0.43613214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02151908
2MP0005360_urolithiasis7.03107547
3MP0005365_abnormal_bile_salt6.00442622
4MP0005085_abnormal_gallbladder_physiolo5.76778792
5MP0008875_abnormal_xenobiotic_pharmacok4.61913128
6MP0008057_abnormal_DNA_replication4.24995506
7MP0002009_preneoplasia3.88836347
8MP0010329_abnormal_lipoprotein_level3.82062045
9MP0003252_abnormal_bile_duct3.75970142
10MP0003806_abnormal_nucleotide_metabolis3.30129982
11MP0008260_abnormal_autophagy3.15333577
12MP0005083_abnormal_biliary_tract2.77296938
13MP0003705_abnormal_hypodermis_morpholog2.69331320
14MP0002822_catalepsy2.65429898
15MP0003195_calcinosis2.60890073
16MP0009840_abnormal_foam_cell2.55695716
17MP0005332_abnormal_amino_acid2.44202351
18MP0003828_pulmonary_edema2.33078593
19MP0010352_gastrointestinal_tract_polyps2.31202697
20MP0001666_abnormal_nutrient_absorption2.29571975
21MP0003091_abnormal_cell_migration2.22911478
22MP0002118_abnormal_lipid_homeostasis2.15391957
23MP0003191_abnormal_cellular_cholesterol2.10892945
24MP0000609_abnormal_liver_physiology2.10698080
25MP0005058_abnormal_lysosome_morphology2.09334720
26MP0004130_abnormal_muscle_cell2.08506641
27MP0003303_peritoneal_inflammation2.06174261
28MP0009278_abnormal_bone_marrow2.05860482
29MP0002396_abnormal_hematopoietic_system2.03903521
30MP0004808_abnormal_hematopoietic_stem1.97905366
31MP0008007_abnormal_cellular_replicative1.97159089
32MP0003077_abnormal_cell_cycle1.95426617
33MP0010094_abnormal_chromosome_stability1.85478433
34MP0003566_abnormal_cell_adhesion1.73820445
35MP0005319_abnormal_enzyme/_coenzyme1.71948750
36MP0003111_abnormal_nucleus_morphology1.63218674
37MP0005670_abnormal_white_adipose1.60186064
38MP0000733_abnormal_muscle_development1.59602779
39MP0004019_abnormal_vitamin_homeostasis1.57487576
40MP0001730_embryonic_growth_arrest1.51269798
41MP0002166_altered_tumor_susceptibility1.49682560
42MP0003172_abnormal_lysosome_physiology1.48307532
43MP0005621_abnormal_cell_physiology1.47980982
44MP0000350_abnormal_cell_proliferation1.47867795
45MP0003693_abnormal_embryo_hatching1.45404827
46MP0003868_abnormal_feces_composition1.43069481
47MP0003436_decreased_susceptibility_to1.34849244
48MP0005584_abnormal_enzyme/coenzyme_acti1.34429874
49MP0002837_dystrophic_cardiac_calcinosis1.33503982
50MP0002998_abnormal_bone_remodeling1.33038658
51MP0001764_abnormal_homeostasis1.29460696
52MP0002088_abnormal_embryonic_growth/wei1.29152792
53MP0004197_abnormal_fetal_growth/weight/1.29096254
54MP0003984_embryonic_growth_retardation1.28747312
55MP0010630_abnormal_cardiac_muscle1.27999605
56MP0009697_abnormal_copulation1.27948092
57MP0005171_absent_coat_pigmentation1.25605314
58MP0002006_tumorigenesis1.23295829
59MP0003300_gastrointestinal_ulcer1.20684682
60MP0005408_hypopigmentation1.20650464
61MP0005451_abnormal_body_composition1.19331282
62MP0010368_abnormal_lymphatic_system1.19035342
63MP0001672_abnormal_embryogenesis/_devel1.18302734
64MP0005380_embryogenesis_phenotype1.18302734
65MP0002971_abnormal_brown_adipose1.17130634
66MP0002092_abnormal_eye_morphology1.16994668
67MP0000598_abnormal_liver_morphology1.14299708
68MP0003634_abnormal_glial_cell1.14156482
69MP0002138_abnormal_hepatobiliary_system1.13667120
70MP0009053_abnormal_anal_canal1.13367891
71MP0004233_abnormal_muscle_weight1.11975240
72MP0002086_abnormal_extraembryonic_tissu1.11939988
73MP0000747_muscle_weakness1.11037805
74MP0000920_abnormal_myelination1.09961729
75MP0001697_abnormal_embryo_size1.09454315
76MP0004957_abnormal_blastocyst_morpholog1.08542118
77MP0005666_abnormal_adipose_tissue1.08404345
78MP0005248_abnormal_Harderian_gland1.07951551
79MP0009780_abnormal_chondrocyte_physiolo1.07629257
80MP0000604_amyloidosis1.06834746
81MP0002078_abnormal_glucose_homeostasis1.05548547
82MP0001853_heart_inflammation1.05435570
83MP0004484_altered_response_of1.03243001
84MP0005384_cellular_phenotype1.02906089
85MP0000313_abnormal_cell_death1.00891503
86MP0005409_darkened_coat_color1.00077533
87MP0003453_abnormal_keratinocyte_physiol0.99743511
88MP0002080_prenatal_lethality0.99075186
89MP0002876_abnormal_thyroid_physiology0.98650092
90MP0002896_abnormal_bone_mineralization0.97262412
91MP0005334_abnormal_fat_pad0.97247943
92MP0009643_abnormal_urine_homeostasis0.96390585
93MP0001346_abnormal_lacrimal_gland0.94064959
94MP0004270_analgesia0.93626154
95MP0005647_abnormal_sex_gland0.92914761
96MP0002419_abnormal_innate_immunity0.92394116
97MP0004185_abnormal_adipocyte_glucose0.89342006
98MP0005187_abnormal_penis_morphology0.86084381
99MP0005220_abnormal_exocrine_pancreas0.84800692
100MP0001529_abnormal_vocalization0.83533236
101MP0003656_abnormal_erythrocyte_physiolo0.82526266
102MP0003632_abnormal_nervous_system0.81676593
103MP0002697_abnormal_eye_size0.81205999
104MP0005535_abnormal_body_temperature0.81162196
105MP0009763_increased_sensitivity_to0.79843234
106MP0000759_abnormal_skeletal_muscle0.79508943
107MP0000343_altered_response_to0.78431830
108MP0003186_abnormal_redox_activity0.78388684
109MP0001851_eye_inflammation0.78299219
110MP0005423_abnormal_somatic_nervous0.78234857
111MP0002269_muscular_atrophy0.77096417
112MP0003136_yellow_coat_color0.76863546
113MP0004947_skin_inflammation0.76134972
114MP0010234_abnormal_vibrissa_follicle0.76126410
115MP0006036_abnormal_mitochondrial_physio0.75389505
116MP0009672_abnormal_birth_weight0.74590515
117MP0001727_abnormal_embryo_implantation0.74410411
118MP0009642_abnormal_blood_homeostasis0.73288389
119MP0002398_abnormal_bone_marrow0.72455075
120MP0000639_abnormal_adrenal_gland0.71712815
121MP0004883_abnormal_blood_vessel0.71303896
122MP0005388_respiratory_system_phenotype0.71227156
123MP0002133_abnormal_respiratory_system0.71227156
124MP0004510_myositis0.70832407
125MP0003329_amyloid_beta_deposits0.70579402
126MP0001340_abnormal_eyelid_morphology0.70287660
127MP0001661_extended_life_span0.69232419
128MP0003763_abnormal_thymus_physiology0.69229096
129MP0002254_reproductive_system_inflammat0.69036428
130MP0003115_abnormal_respiratory_system0.68779126
131MP0003448_altered_tumor_morphology0.67907098
132MP0005448_abnormal_energy_balance0.67741947
133MP0002085_abnormal_embryonic_tissue0.67624584
134MP0005376_homeostasis/metabolism_phenot0.67394749
135MP0005636_abnormal_mineral_homeostasis0.67179386
136MP0002877_abnormal_melanocyte_morpholog0.66662084
137MP0009115_abnormal_fat_cell0.65479123
138MP0002925_abnormal_cardiovascular_devel0.65153287
139MP0002249_abnormal_larynx_morphology0.64728622
140MP0003890_abnormal_embryonic-extraembry0.63779007
141MP0004859_abnormal_synaptic_plasticity0.61842592
142MP0005266_abnormal_metabolism0.60878697
143MP0005395_other_phenotype0.59841204
144MP0002909_abnormal_adrenal_gland0.59674709
145MP0002168_other_aberrant_phenotype0.59054685
146MP0004782_abnormal_surfactant_physiolog0.57190564
147MP0003011_delayed_dark_adaptation0.56725699
148MP0002090_abnormal_vision0.55612308
149MP0005375_adipose_tissue_phenotype0.54821207
150MP0002970_abnormal_white_adipose0.54118506
151MP0003646_muscle_fatigue0.53807920
152MP0009384_cardiac_valve_regurgitation0.53758614
153MP0009764_decreased_sensitivity_to0.53596538
154MP0000427_abnormal_hair_cycle0.52942603
155MP0003690_abnormal_glial_cell0.52043712
156MP0003953_abnormal_hormone_level0.51165651
157MP0001756_abnormal_urination0.51005354
158MP0001177_atelectasis0.48826192
159MP0008438_abnormal_cutaneous_collagen0.48778846
160MP0004264_abnormal_extraembryonic_tissu0.48055008
161MP0000566_synostosis0.47968416
162MP0006035_abnormal_mitochondrial_morpho0.44594334
163MP0000569_abnormal_digit_pigmentation0.43950730
164MP0003221_abnormal_cardiomyocyte_apopto0.43535061
165MP0004087_abnormal_muscle_fiber0.43356383
166MP0008469_abnormal_protein_level0.43225155
167MP0001915_intracranial_hemorrhage0.42853243
168MP0005076_abnormal_cell_differentiation0.42559599
169MP0000579_abnormal_nail_morphology0.42425438
170MP0003075_altered_response_to0.41533200
171MP0000013_abnormal_adipose_tissue0.40663522
172MP0001944_abnormal_pancreas_morphology0.40494479
173MP0010307_abnormal_tumor_latency0.40208625
174MP0008961_abnormal_basal_metabolism0.38803044
175MP0001324_abnormal_eye_pigmentation0.38527810
176MP0003718_maternal_effect0.38287970
177MP0002060_abnormal_skin_morphology0.36679062

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.13563261
2Intrahepatic cholestasis (HP:0001406)6.45953090
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.92709647
4Xanthomatosis (HP:0000991)5.72847750
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.69749902
6Hypobetalipoproteinemia (HP:0003563)5.54889896
7Prolonged partial thromboplastin time (HP:0003645)5.38314330
8Hyperlipoproteinemia (HP:0010980)4.94315384
9Complement deficiency (HP:0004431)4.80614331
10Epidermoid cyst (HP:0200040)4.77673436
11Hypolipoproteinemia (HP:0010981)4.59567462
12Ketosis (HP:0001946)4.47404053
13Hypoalphalipoproteinemia (HP:0003233)4.42234511
14Hyperammonemia (HP:0001987)4.24787552
15Hypoglycemic coma (HP:0001325)4.22053150
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20530932
17Hyperglycinemia (HP:0002154)4.15383451
18Abnormality of the common coagulation pathway (HP:0010990)4.12872681
19Joint hemorrhage (HP:0005261)3.91154455
20Abnormality of the intrinsic pathway (HP:0010989)3.84736016
21Hyperglycinuria (HP:0003108)3.83743623
22Ketoacidosis (HP:0001993)3.83382507
23Abnormality of glycine metabolism (HP:0010895)3.72614285
24Abnormality of serine family amino acid metabolism (HP:0010894)3.72614285
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.67321001
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.66756942
27Hypercholesterolemia (HP:0003124)3.60435988
28Fat malabsorption (HP:0002630)3.44831744
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.34685175
30Abnormality of complement system (HP:0005339)3.33947996
31Abnormality of methionine metabolism (HP:0010901)3.30572261
32Skin nodule (HP:0200036)3.27267507
33Abnormality of fatty-acid metabolism (HP:0004359)3.11055595
34Hepatocellular carcinoma (HP:0001402)3.08558905
35Broad face (HP:0000283)3.04138218
36Myocardial infarction (HP:0001658)3.00437514
37Abnormality of pyrimidine metabolism (HP:0004353)2.99047874
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.97493478
39Abnormality of nucleobase metabolism (HP:0010932)2.94935603
40Abnormality of purine metabolism (HP:0004352)2.92879467
41Spontaneous abortion (HP:0005268)2.88202450
42Hyperglycemia (HP:0003074)2.87832475
43Termporal pattern (HP:0011008)2.81276885
44Insidious onset (HP:0003587)2.81276885
45Conjugated hyperbilirubinemia (HP:0002908)2.75992753
46Hyperbilirubinemia (HP:0002904)2.71114411
47Heterotopia (HP:0002282)2.70817620
48Spastic diplegia (HP:0001264)2.69707550
49Hypochromic microcytic anemia (HP:0004840)2.67374229
50Gout (HP:0001997)2.66509258
51Slow saccadic eye movements (HP:0000514)2.61456480
52Subaortic stenosis (HP:0001682)2.60739952
53Abnormality of the left ventricular outflow tract (HP:0011103)2.60739952
54Hypoglycemic seizures (HP:0002173)2.59448987
55Papillary thyroid carcinoma (HP:0002895)2.58668580
56Syringomyelia (HP:0003396)2.57606314
57Spinal cord lesions (HP:0100561)2.57606314
58Deep philtrum (HP:0002002)2.57096854
59Abnormality of serum amino acid levels (HP:0003112)2.54690271
60Hyperinsulinemic hypoglycemia (HP:0000825)2.52638228
61Abnormal gallbladder morphology (HP:0012437)2.51701695
62Cholelithiasis (HP:0001081)2.50182953
63Neuronal loss in central nervous system (HP:0002529)2.47639517
64Metabolic acidosis (HP:0001942)2.43568230
65Missing ribs (HP:0000921)2.42444187
66Medulloblastoma (HP:0002885)2.40386495
67Abnormal gallbladder physiology (HP:0012438)2.39219059
68Cholecystitis (HP:0001082)2.39219059
69Acanthocytosis (HP:0001927)2.38460915
70Dysmetric saccades (HP:0000641)2.38340955
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.35908489
72Steatorrhea (HP:0002570)2.33777433
73Mitral stenosis (HP:0001718)2.33206780
74Esophageal varix (HP:0002040)2.31684482
75Bladder carcinoma (HP:0002862)2.30409783
76Bladder neoplasm (HP:0009725)2.30409783
77Peripheral hypomyelination (HP:0007182)2.30388457
78Menstrual irregularities (HP:0000858)2.28847677
79Vertebral arch anomaly (HP:0008438)2.27035487
80Dicarboxylic aciduria (HP:0003215)2.22570769
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22570769
82Uterine leiomyosarcoma (HP:0002891)2.20542303
83Leiomyosarcoma (HP:0100243)2.20542303
84Sensorimotor neuropathy (HP:0007141)2.19989253
85Neonatal onset (HP:0003623)2.19793113
86Delayed CNS myelination (HP:0002188)2.19505902
87Supernumerary ribs (HP:0005815)2.19150739
88Decreased motor nerve conduction velocity (HP:0003431)2.18773547
89Transitional cell carcinoma of the bladder (HP:0006740)2.16407903
90Overlapping toe (HP:0001845)2.15687039
91Myoglobinuria (HP:0002913)2.15034517
92Large earlobe (HP:0009748)2.13130610
93Progressive external ophthalmoplegia (HP:0000590)2.11925701
94Embryonal renal neoplasm (HP:0011794)2.11899141
95Acute myeloid leukemia (HP:0004808)2.10569147
96Lower limb amyotrophy (HP:0007210)2.09882303
97Abnormality of the lower motor neuron (HP:0002366)2.09517183
98Upper motor neuron abnormality (HP:0002127)2.06555953
99Abnormal cartilage morphology (HP:0002763)2.06297083
100Abnormality of the gallbladder (HP:0005264)2.05415431
101Nephroblastoma (Wilms tumor) (HP:0002667)2.03921640
102Scanning speech (HP:0002168)2.03850331
103Disinhibition (HP:0000734)2.03658232
104Late onset (HP:0003584)2.01345740
105Long eyelashes (HP:0000527)2.01305059
106Hyperacusis (HP:0010780)2.00726681
107Disproportionate tall stature (HP:0001519)2.00375204
108Renal cell carcinoma (HP:0005584)1.98958107
109Increased purine levels (HP:0004368)1.98018309
110Hyperuricemia (HP:0002149)1.98018309
111Turricephaly (HP:0000262)1.97992612
112Arterial tortuosity (HP:0005116)1.97573804
113Vascular calcification (HP:0004934)1.95761207
114Increased nuchal translucency (HP:0010880)1.95515369
115Basal cell carcinoma (HP:0002671)1.94799281
116Cortical dysplasia (HP:0002539)1.94024904
117Apathy (HP:0000741)1.93334787
118Toxemia of pregnancy (HP:0100603)1.93121429
119Enlarged kidneys (HP:0000105)1.91927048
120Lethargy (HP:0001254)1.91896550
121Viral hepatitis (HP:0006562)1.91644215
122Status epilepticus (HP:0002133)1.91102742
123Asymmetry of the thorax (HP:0001555)1.90925426
124Recurrent gram-negative bacterial infections (HP:0005420)1.89945243
125Cerebral edema (HP:0002181)1.88814808
126Relative macrocephaly (HP:0004482)1.88679950
127Arnold-Chiari malformation (HP:0002308)1.87610233
128Flat occiput (HP:0005469)1.87421831
129Global brain atrophy (HP:0002283)1.87147275
130Ankyloglossia (HP:0010296)1.86647078
131Systemic lupus erythematosus (HP:0002725)1.86006594
132Cardiovascular calcification (HP:0011915)1.85632877
133Hemorrhage of the eye (HP:0011885)1.84833370
134Thrombophlebitis (HP:0004418)1.84465912
135Irritability (HP:0000737)1.84347255
136Pancreatitis (HP:0001733)1.83975166
137Subacute progressive viral hepatitis (HP:0006572)1.83725384
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83646733
139Truncal obesity (HP:0001956)1.82776913
140Tetraparesis (HP:0002273)1.82717888
141Abnormality of chromosome segregation (HP:0002916)1.82663942
142Hydroxyprolinuria (HP:0003080)1.82414405
143Abnormality of proline metabolism (HP:0010907)1.82414405
144Malnutrition (HP:0004395)1.82311616
145Capillary hemangiomas (HP:0005306)1.81852055
146Gastrointestinal carcinoma (HP:0002672)1.81817856
147Malignant gastrointestinal tract tumors (HP:0006749)1.81817856
148Supranuclear gaze palsy (HP:0000605)1.80764786
149Spontaneous hematomas (HP:0007420)1.79207579
150Acute lymphatic leukemia (HP:0006721)1.79103743
151Cellulitis (HP:0100658)1.78337279
152Dislocated radial head (HP:0003083)1.78200907
153Generalized aminoaciduria (HP:0002909)1.77576492
154Vomiting (HP:0002013)1.76864805
155Low anterior hairline (HP:0000294)1.76694623
156Vascular tortuosity (HP:0004948)1.76120256
157Lymphangioma (HP:0100764)1.75509734
158Proximal tubulopathy (HP:0000114)1.75038396
159Narrow palate (HP:0000189)1.75010698
160Neurofibrillary tangles (HP:0002185)1.74828919
161Insomnia (HP:0100785)1.73812038
162Neoplasm of the heart (HP:0100544)1.73412012
163Poikilocytosis (HP:0004447)1.71954904
164Hypertriglyceridemia (HP:0002155)1.71384078
165Reticulocytosis (HP:0001923)1.70703687
166Renal cortical cysts (HP:0000803)1.69477474
167Exercise-induced muscle cramps (HP:0003710)1.69431954
168Acute hepatic failure (HP:0006554)1.68439940
169Diminished motivation (HP:0000745)1.68371184
170Abnormality of the fingertips (HP:0001211)1.68060771
171Back pain (HP:0003418)1.67843626
172Obsessive-compulsive behavior (HP:0000722)1.67141984
173Cerebral inclusion bodies (HP:0100314)1.66198294
174Abnormality of the radial head (HP:0003995)1.65092404
175Supernumerary bones of the axial skeleton (HP:0009144)1.64967103
176Achilles tendon contracture (HP:0001771)1.64621946
177Facial hemangioma (HP:0000329)1.64223201
178Germ cell neoplasia (HP:0100728)1.62173643
179Smooth philtrum (HP:0000319)1.61798640
180Hypopigmentation of the fundus (HP:0007894)1.61757610
181Inappropriate behavior (HP:0000719)1.61401743
182Deviation of the thumb (HP:0009603)1.61358921
183Upper limb muscle weakness (HP:0003484)1.60596176
184Bowel incontinence (HP:0002607)1.59533611
185Glossoptosis (HP:0000162)1.59033584
186EMG: neuropathic changes (HP:0003445)1.58849390
187Somatic mutation (HP:0001428)1.58716261
188Overgrowth (HP:0001548)1.58596311
189Macroorchidism (HP:0000053)1.58337373
190Urinary urgency (HP:0000012)1.57839722
191Supernumerary nipples (HP:0002558)1.57074380
192Hammertoe (HP:0001765)1.55841965
193Distal lower limb amyotrophy (HP:0008944)1.55545400
194Broad nasal tip (HP:0000455)1.54307771
195Sparse lateral eyebrow (HP:0005338)1.53270739
196Ulnar bowing (HP:0003031)1.52198527
197Urethral obstruction (HP:0000796)1.52093108
198Lower limb muscle weakness (HP:0007340)1.52044232
199Neoplasm of the oral cavity (HP:0100649)1.51760622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.74946260
2PRPF4B4.03988053
3BCKDK3.69444651
4SIK13.63315887
5PNCK3.17242024
6TRIB33.11018943
7PKN23.01046273
8NEK12.54440105
9FGFR42.49377319
10ERN12.37996443
11STK38L2.33421251
12PDK32.23128822
13PDK42.23128822
14FRK2.19456269
15MAP2K42.00484430
16ERBB41.89671389
17DAPK21.87799912
18TAOK31.86914697
19INSRR1.84652871
20RIPK11.76851117
21NEK91.76833081
22IRAK31.70044364
23LATS21.69490178
24ICK1.55579141
25PDK21.54881132
26RIPK41.51610299
27WEE11.50684614
28FGFR21.46268092
29MAP3K141.46193060
30MAP3K21.45797894
31EIF2AK31.36076661
32CAMK1D1.33196470
33PDGFRA1.31759809
34PTK61.30558063
35CDK61.29453026
36SGK21.28642922
37SGK31.27946587
38TSSK61.27446150
39STK31.26085655
40TTN1.24141686
41ARAF1.22726894
42FLT31.22716840
43RAF11.21227617
44BLK1.18461039
45PRKD31.16961260
46MAP2K21.15741806
47MKNK21.14086799
48MAP3K101.13910206
49MAP3K71.13038657
50FGFR31.11992872
51MAP3K31.11430149
52OBSCN1.10078921
53AKT31.09517885
54MST1R1.07632180
55IRAK21.05445081
56STK381.04704865
57MOS1.03987423
58MAPK111.01301477
59DMPK0.99031594
60PIK3CG0.98038096
61CDC70.97019859
62JAK20.92448017
63CAMK40.92225590
64WNK10.92018516
65MARK20.91656211
66PRKAA10.90599779
67FGFR10.89529203
68KSR20.86834866
69PRKAA20.84088991
70NEK60.83836728
71TAOK20.82593068
72RET0.82318956
73MAP3K40.82166788
74SRPK10.81386868
75IRAK40.80074955
76EEF2K0.79756118
77TBK10.77338260
78MAPK70.76220108
79MAPK100.74688378
80MTOR0.73541063
81BMPR20.71239037
82SGK4940.71092819
83SGK2230.71092819
84SMG10.69554336
85CDK90.68482610
86BRAF0.67308604
87NUAK10.66976844
88RPS6KC10.65333619
89RPS6KL10.65333619
90FER0.65190326
91JAK10.65170827
92CAMK1G0.64746552
93MAP3K10.64357510
94FGR0.63353770
95CAMKK10.62647511
96IKBKE0.61854385
97MAP2K10.61229419
98BRD40.61221090
99ABL20.60852957
100PINK10.60699701
101RPS6KA10.59392504
102CDK40.59320755
103EIF2AK10.59039389
104CHEK10.58893172
105PDGFRB0.58605086
106CHUK0.58098339
107PAK20.57425884
108LMTK20.57349766
109YES10.57297949
110MAP3K60.55799059
111PRKCH0.55598513
112EPHA40.55253993
113CDK30.54212445
114RPS6KA40.53931524
115MAP2K30.53641209
116IRAK10.52628058
117MKNK10.51827197
118CDK70.51743751
119MAP3K50.50391558
120CDC42BPA0.50078092
121CCNB10.47291311
122PDPK10.46179313
123RPS6KB10.46086525
124PDK10.45370935
125MELK0.44321124
126PAK60.43970707
127PTK20.43905044
128ALK0.43775108
129PIM10.43435065
130PIK3CA0.43100107
131CSF1R0.42924735
132ZAP700.42271254
133CDK10.41694199
134PRKACG0.41639152
135MAP3K80.41398952
136RPS6KA60.41088736
137SIK20.40091237
138RPS6KA20.39838224
139CDK20.39568039
140CDK120.39356810
141PLK40.39332472
142TAOK10.39292183
143SCYL20.37173252
144DYRK1B0.37030223
145IGF1R0.36990936
146GSK3A0.36704741
147KSR10.35778323
148RPS6KA30.34989859
149TYK20.34810955
150PRKCZ0.34314666
151TTK0.34053170
152ERBB20.33042650
153SGK10.32925333
154EGFR0.32215499
155PAK30.31434772
156MAP3K90.28972859
157PRKACB0.24161261
158MAP3K130.23958414
159DDR20.22801993
160ERBB30.22252208

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54312001
2Nitrogen metabolism_Homo sapiens_hsa009103.82892426
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51021441
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14461889
5Arginine biosynthesis_Homo sapiens_hsa002203.09441368
6Fatty acid degradation_Homo sapiens_hsa000712.75946298
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66033694
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52050594
9Complement and coagulation cascades_Homo sapiens_hsa046102.50908762
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48069139
11Tryptophan metabolism_Homo sapiens_hsa003802.42841584
12Propanoate metabolism_Homo sapiens_hsa006402.36551815
13Chronic myeloid leukemia_Homo sapiens_hsa052202.16089724
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15108679
15PPAR signaling pathway_Homo sapiens_hsa033202.12574094
16Caffeine metabolism_Homo sapiens_hsa002322.08418504
17Fatty acid metabolism_Homo sapiens_hsa012122.07244475
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05191464
19Butanoate metabolism_Homo sapiens_hsa006502.02136619
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96311286
21B cell receptor signaling pathway_Homo sapiens_hsa046621.94482375
22Renal cell carcinoma_Homo sapiens_hsa052111.91951754
23Peroxisome_Homo sapiens_hsa041461.91910215
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89958738
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82400626
26Pyruvate metabolism_Homo sapiens_hsa006201.74648486
27Pancreatic cancer_Homo sapiens_hsa052121.73671104
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.73221041
29Acute myeloid leukemia_Homo sapiens_hsa052211.69103243
30Chemical carcinogenesis_Homo sapiens_hsa052041.58663207
31Selenocompound metabolism_Homo sapiens_hsa004501.55192057
32Colorectal cancer_Homo sapiens_hsa052101.54795887
33Osteoclast differentiation_Homo sapiens_hsa043801.54080741
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.53154890
35beta-Alanine metabolism_Homo sapiens_hsa004101.52513654
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.50734578
37Bile secretion_Homo sapiens_hsa049761.50315014
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50020682
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.49826322
40Carbon metabolism_Homo sapiens_hsa012001.49275818
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46191358
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45095863
43Endometrial cancer_Homo sapiens_hsa052131.44500987
44ErbB signaling pathway_Homo sapiens_hsa040121.43081213
45Staphylococcus aureus infection_Homo sapiens_hsa051501.42418984
46Biosynthesis of amino acids_Homo sapiens_hsa012301.42135442
47Starch and sucrose metabolism_Homo sapiens_hsa005001.39519177
48Hepatitis B_Homo sapiens_hsa051611.39378690
49MicroRNAs in cancer_Homo sapiens_hsa052061.38707657
50Estrogen signaling pathway_Homo sapiens_hsa049151.38629032
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37654921
52Phenylalanine metabolism_Homo sapiens_hsa003601.36322315
53VEGF signaling pathway_Homo sapiens_hsa043701.34217966
54mRNA surveillance pathway_Homo sapiens_hsa030151.32850596
55Retinol metabolism_Homo sapiens_hsa008301.32475199
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32351813
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.32151463
58Prostate cancer_Homo sapiens_hsa052151.31893898
59Histidine metabolism_Homo sapiens_hsa003401.28946362
60Cell cycle_Homo sapiens_hsa041101.26021699
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25105056
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24537805
63Tyrosine metabolism_Homo sapiens_hsa003501.23678610
64Other glycan degradation_Homo sapiens_hsa005111.21506260
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21031845
66Fatty acid biosynthesis_Homo sapiens_hsa000611.20985030
67Prolactin signaling pathway_Homo sapiens_hsa049171.20859007
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18673610
69Notch signaling pathway_Homo sapiens_hsa043301.17765781
70Long-term potentiation_Homo sapiens_hsa047201.16031279
71Legionellosis_Homo sapiens_hsa051341.14673640
72Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14020369
73Fat digestion and absorption_Homo sapiens_hsa049751.13123673
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11098548
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10575046
76Choline metabolism in cancer_Homo sapiens_hsa052311.09204279
77Sulfur metabolism_Homo sapiens_hsa009201.08585358
78Viral carcinogenesis_Homo sapiens_hsa052031.06294127
79Lysine degradation_Homo sapiens_hsa003101.05529816
80Small cell lung cancer_Homo sapiens_hsa052221.04825736
81ABC transporters_Homo sapiens_hsa020101.03644800
82HIF-1 signaling pathway_Homo sapiens_hsa040661.02392667
83Phospholipase D signaling pathway_Homo sapiens_hsa040721.01955920
84GnRH signaling pathway_Homo sapiens_hsa049121.00673611
85Inositol phosphate metabolism_Homo sapiens_hsa005621.00427505
86Apoptosis_Homo sapiens_hsa042100.99592557
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.97323711
88Thyroid cancer_Homo sapiens_hsa052160.97124994
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96978613
90Leishmaniasis_Homo sapiens_hsa051400.96291519
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95160490
92Proteoglycans in cancer_Homo sapiens_hsa052050.94899353
93TNF signaling pathway_Homo sapiens_hsa046680.94239329
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93851918
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.92562151
96Glycerolipid metabolism_Homo sapiens_hsa005610.92196080
97Tuberculosis_Homo sapiens_hsa051520.91483895
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91276430
99Influenza A_Homo sapiens_hsa051640.89256913
100Spliceosome_Homo sapiens_hsa030400.88865766
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84519896
102One carbon pool by folate_Homo sapiens_hsa006700.84070429
103Toxoplasmosis_Homo sapiens_hsa051450.82249027
104MAPK signaling pathway_Homo sapiens_hsa040100.82133093
105RNA transport_Homo sapiens_hsa030130.79320866
106Sulfur relay system_Homo sapiens_hsa041220.75401096
107Shigellosis_Homo sapiens_hsa051310.75339880
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74938528
109Fatty acid elongation_Homo sapiens_hsa000620.74903537
110Salmonella infection_Homo sapiens_hsa051320.74137017
111Gap junction_Homo sapiens_hsa045400.73340862
112Measles_Homo sapiens_hsa051620.73159375
113HTLV-I infection_Homo sapiens_hsa051660.72897950
114Melanoma_Homo sapiens_hsa052180.72821593
115T cell receptor signaling pathway_Homo sapiens_hsa046600.72797604
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72621536
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72450427
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71912703
119Folate biosynthesis_Homo sapiens_hsa007900.69435236
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69431730
121Epstein-Barr virus infection_Homo sapiens_hsa051690.68603541
122Pentose phosphate pathway_Homo sapiens_hsa000300.67146135
123Pathways in cancer_Homo sapiens_hsa052000.67144033
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66443694
125Vitamin B6 metabolism_Homo sapiens_hsa007500.63843351
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63809333
127Hepatitis C_Homo sapiens_hsa051600.62809418
128Glucagon signaling pathway_Homo sapiens_hsa049220.62104427
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.62088182
130Insulin resistance_Homo sapiens_hsa049310.61944504
131Long-term depression_Homo sapiens_hsa047300.60966912
132Arginine and proline metabolism_Homo sapiens_hsa003300.60482284
133Endocytosis_Homo sapiens_hsa041440.59978512
134Rap1 signaling pathway_Homo sapiens_hsa040150.59027678
135Focal adhesion_Homo sapiens_hsa045100.57953548
136Lysosome_Homo sapiens_hsa041420.57822026
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56658199
138Steroid biosynthesis_Homo sapiens_hsa001000.56065184
139Herpes simplex infection_Homo sapiens_hsa051680.55630678
140Alcoholism_Homo sapiens_hsa050340.55490263
141DNA replication_Homo sapiens_hsa030300.55338841
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.55063050
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.54473988
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53181434
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50775462
146Vitamin digestion and absorption_Homo sapiens_hsa049770.49667189
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48602853
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40555105
149AMPK signaling pathway_Homo sapiens_hsa041520.40226355
150Galactose metabolism_Homo sapiens_hsa000520.36312508
151Insulin signaling pathway_Homo sapiens_hsa049100.34006991
152Glutathione metabolism_Homo sapiens_hsa004800.29129207
153Fructose and mannose metabolism_Homo sapiens_hsa000510.28702133
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.26323011
155Metabolic pathways_Homo sapiens_hsa011000.26191440
156Prion diseases_Homo sapiens_hsa050200.24961423
157Type II diabetes mellitus_Homo sapiens_hsa049300.20118776
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14537221
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13267708
160mTOR signaling pathway_Homo sapiens_hsa041500.12825784
161Ovarian steroidogenesis_Homo sapiens_hsa049130.12140342
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.10645382
163Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10381745
164Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05806246
165Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05496926
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03575967
167Systemic lupus erythematosus_Homo sapiens_hsa053220.02258731
168Circadian rhythm_Homo sapiens_hsa047100.01811322
169alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01219408
170Thyroid hormone synthesis_Homo sapiens_hsa049180.01194332
171Adherens junction_Homo sapiens_hsa04520-0.1469504
172Glioma_Homo sapiens_hsa05214-0.1292606
173Non-small cell lung cancer_Homo sapiens_hsa05223-0.1277507
174Linoleic acid metabolism_Homo sapiens_hsa00591-0.1274983
175Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1188386
176Amoebiasis_Homo sapiens_hsa05146-0.1133489
177Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0503127
178Bladder cancer_Homo sapiens_hsa05219-0.0070259
179FoxO signaling pathway_Homo sapiens_hsa04068-0.0034063

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »