GZMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.59358725
2regulation of natural killer cell mediated cytotoxicity (GO:0042269)8.88122666
3regulation of natural killer cell mediated immunity (GO:0002715)8.88122666
4DNA deamination (GO:0045006)8.60781055
5cellular response to interleukin-15 (GO:0071350)8.01291595
6activated T cell proliferation (GO:0050798)7.97180844
7positive regulation of gamma-delta T cell activation (GO:0046645)7.76072276
8cellular defense response (GO:0006968)7.31569552
9negative T cell selection (GO:0043383)7.22240035
10response to interleukin-15 (GO:0070672)7.10684187
11negative thymic T cell selection (GO:0045060)6.98223142
12regulation of isotype switching to IgG isotypes (GO:0048302)6.95724003
13T cell migration (GO:0072678)6.90223576
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.66583975
15negative regulation of cell killing (GO:0031342)6.66583975
16* cytolysis (GO:0019835)6.34366988
17positive regulation of natural killer cell mediated immunity (GO:0002717)6.26142316
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.26142316
19regulation of gamma-delta T cell differentiation (GO:0045586)6.20375811
20positive thymic T cell selection (GO:0045059)6.19912445
21thymic T cell selection (GO:0045061)5.80272648
22regulation of leukocyte mediated cytotoxicity (GO:0001910)5.76231452
23positive T cell selection (GO:0043368)5.76081710
24natural killer cell activation (GO:0030101)5.71356748
25positive regulation of isotype switching (GO:0045830)5.52626652
26regulation of gamma-delta T cell activation (GO:0046643)5.49329995
27actin nucleation (GO:0045010)5.31735082
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.26694263
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26694263
30regulation of cell killing (GO:0031341)5.25515796
31leukocyte aggregation (GO:0070486)5.13990933
32heterotypic cell-cell adhesion (GO:0034113)5.05252358
33T cell selection (GO:0045058)4.96510613
34sequestering of actin monomers (GO:0042989)4.91086971
35negative regulation of T cell apoptotic process (GO:0070233)4.84657455
36negative regulation of viral genome replication (GO:0045071)4.81468118
37regulation of activation of Janus kinase activity (GO:0010533)4.78816625
38pyrimidine nucleoside catabolic process (GO:0046135)4.76425124
39positive regulation of DNA recombination (GO:0045911)4.73891685
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.70311898
41leukocyte cell-cell adhesion (GO:0007159)4.70074011
42positive regulation of calcium-mediated signaling (GO:0050850)4.59492963
43positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.57513436
44T cell costimulation (GO:0031295)4.55585328
45lymphocyte costimulation (GO:0031294)4.54812361
46lymphocyte migration (GO:0072676)4.45174341
47regulation of isotype switching (GO:0045191)4.40732163
48positive regulation of B cell mediated immunity (GO:0002714)4.39202460
49positive regulation of immunoglobulin mediated immune response (GO:0002891)4.39202460
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.38142896
51T cell receptor signaling pathway (GO:0050852)4.33016438
52regulation of regulatory T cell differentiation (GO:0045589)4.30506474
53antigen processing and presentation of endogenous antigen (GO:0019883)4.28053014
54positive regulation of cell killing (GO:0031343)4.27815616
55regulation of B cell receptor signaling pathway (GO:0050855)4.25834253
56negative regulation of stress fiber assembly (GO:0051497)4.23033794
57negative regulation of T cell mediated immunity (GO:0002710)4.21079284
58positive regulation of tolerance induction (GO:0002645)4.10654283
59lymphocyte chemotaxis (GO:0048247)4.09373289
60alpha-beta T cell differentiation involved in immune response (GO:0002293)4.09046090
61alpha-beta T cell activation involved in immune response (GO:0002287)4.09046090
62T cell differentiation involved in immune response (GO:0002292)4.09046090
63positive regulation of interleukin-8 secretion (GO:2000484)4.03787967
64eosinophil chemotaxis (GO:0048245)3.97363844
65negative regulation by host of viral transcription (GO:0043922)3.97166617
66regulation of lymphocyte mediated immunity (GO:0002706)3.96938432
67macrophage chemotaxis (GO:0048246)3.96767855
68positive regulation of monocyte chemotaxis (GO:0090026)3.92506932
69leukocyte tethering or rolling (GO:0050901)3.91594875
70mast cell activation (GO:0045576)3.91251068
71positive regulation of immunoglobulin production (GO:0002639)3.87306287
72positive regulation of B cell differentiation (GO:0045579)3.83837281
73alpha-beta T cell activation (GO:0046631)3.80693128
74T cell activation involved in immune response (GO:0002286)3.80294155
75positive regulation of T cell mediated cytotoxicity (GO:0001916)3.72733121
76regulation of immunoglobulin mediated immune response (GO:0002889)3.71671718
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.70702766
78antigen receptor-mediated signaling pathway (GO:0050851)3.69794678
79regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.68644122
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68434114
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65205925
82regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.65113719
83regulation of response to interferon-gamma (GO:0060330)3.61811820
84regulation of hypersensitivity (GO:0002883)3.60496146
85eosinophil migration (GO:0072677)3.60464570
86alpha-beta T cell differentiation (GO:0046632)3.58850689
87regulation of B cell mediated immunity (GO:0002712)3.58253924
88T cell proliferation (GO:0042098)3.54000619
89regulation of tolerance induction (GO:0002643)3.53893238
90Arp2/3 complex-mediated actin nucleation (GO:0034314)3.52825854
91substrate-dependent cell migration (GO:0006929)3.52278648
92negative regulation of execution phase of apoptosis (GO:1900118)3.50498399
93positive regulation of lymphocyte mediated immunity (GO:0002708)3.46706374
94positive regulation of alpha-beta T cell proliferation (GO:0046641)3.44309608
95regulation of alpha-beta T cell proliferation (GO:0046640)3.44220010
96regulation of viral genome replication (GO:0045069)3.43563310
97regulation of B cell differentiation (GO:0045577)3.43016838
98T cell differentiation (GO:0030217)3.42488426
99positive regulation of defense response to virus by host (GO:0002230)3.41530970
100positive regulation of interleukin-4 production (GO:0032753)3.40734819
101regulation of T cell mediated cytotoxicity (GO:0001914)3.40538508
102regulation of T cell apoptotic process (GO:0070232)3.38371849
103CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.37968209
104T-helper cell differentiation (GO:0042093)3.37968209
105regulation of calcium-mediated signaling (GO:0050848)3.37143860
106T cell activation (GO:0042110)3.30386537
107antigen processing and presentation via MHC class Ib (GO:0002475)3.29227190
108regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28022093
109negative regulation of lymphocyte apoptotic process (GO:0070229)3.25993026
110regulation of immunoglobulin production (GO:0002637)3.21621116
111negative regulation of nitric oxide biosynthetic process (GO:0045019)3.21212436
112positive regulation of lymphocyte migration (GO:2000403)3.21187949
113response to protozoan (GO:0001562)3.21107289
114negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.20548567
115chemokine-mediated signaling pathway (GO:0070098)3.19569886
116regulation of T cell tolerance induction (GO:0002664)3.18882558
117respiratory burst (GO:0045730)3.17113974
118regulation of interleukin-8 secretion (GO:2000482)3.16551928
119regulation of lymphocyte chemotaxis (GO:1901623)3.14497738
120dendritic cell chemotaxis (GO:0002407)3.14471860
121regulation of leukocyte mediated immunity (GO:0002703)3.14203886
122negative regulation of actin filament bundle assembly (GO:0032232)3.13982861
123response to interferon-beta (GO:0035456)3.11663096
124negative regulation of interleukin-12 production (GO:0032695)3.10391139
125positive regulation of lamellipodium assembly (GO:0010592)3.09494313
126regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08053605
127negative regulation of lymphocyte mediated immunity (GO:0002707)3.06666104
128regulation of chemokine-mediated signaling pathway (GO:0070099)3.06172802
129B cell receptor signaling pathway (GO:0050853)3.05986982
130regulation of interleukin-2 biosynthetic process (GO:0045076)3.05965868
131regulation of defense response to virus by virus (GO:0050690)3.04120162
132regulation of T cell chemotaxis (GO:0010819)3.00567790
133positive regulation of T cell chemotaxis (GO:0010820)3.00567790
134immunoglobulin mediated immune response (GO:0016064)3.00414299
135regulation of T cell receptor signaling pathway (GO:0050856)3.00309626
136T cell homeostasis (GO:0043029)2.94894581
137negative regulation of viral process (GO:0048525)2.93507370
138positive regulation of leukocyte mediated immunity (GO:0002705)2.91731749
139positive regulation of T cell apoptotic process (GO:0070234)2.91119086
140hypotonic response (GO:0006971)2.90704564
141positive regulation of humoral immune response (GO:0002922)2.90334753
142regulation of chronic inflammatory response (GO:0002676)2.89476314
143cytidine metabolic process (GO:0046087)10.7258425
144cytidine catabolic process (GO:0006216)10.7258425
145cytidine deamination (GO:0009972)10.7258425
146interferon-gamma production (GO:0032609)10.5053323
147regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.1192189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.47968919
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.56239225
3E2F7_22180533_ChIP-Seq_HELA_Human5.30514909
4* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.54464496
5STAT4_19710469_ChIP-ChIP_TH1__Mouse4.39302934
6RUNX_20019798_ChIP-Seq_JUKART_Human4.06330374
7MYB_26560356_Chip-Seq_TH2_Human3.73098426
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.50731850
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.30420320
10* MAF_26560356_Chip-Seq_TH1_Human3.06420178
11MYB_26560356_Chip-Seq_TH1_Human2.97781552
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93105946
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.91201180
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.87261431
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.86458145
16MYC_22102868_ChIP-Seq_BL_Human2.78830270
17* UTX_26944678_Chip-Seq_JUKART_Human2.74909597
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71877151
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54893206
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.50166412
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48358959
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.44884096
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28508670
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25883624
25VDR_21846776_ChIP-Seq_THP-1_Human2.23848011
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.23488895
27GATA3_27048872_Chip-Seq_THYMUS_Human2.22964211
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18323334
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09360813
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.08682394
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.07609376
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03867991
33TCF7_22412390_ChIP-Seq_EML_Mouse1.95230921
34SPI1_23547873_ChIP-Seq_NB4_Human1.95214284
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.94485956
36MAF_26560356_Chip-Seq_TH2_Human1.92135079
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86505197
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85559153
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81402885
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76246531
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76050038
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75153928
43* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70278274
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65872925
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65209145
46KDM2B_26808549_Chip-Seq_DND41_Human1.61305523
47VDR_24763502_ChIP-Seq_THP-1_Human1.61091738
48SCL_19346495_ChIP-Seq_HPC-7_Human1.56392075
49* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56258982
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53917180
51SPI1_23127762_ChIP-Seq_K562_Human1.52697476
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48084438
53BCL6_27268052_Chip-Seq_Bcells_Human1.45867348
54GATA3_26560356_Chip-Seq_TH2_Human1.45206266
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36749512
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33904565
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33427511
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33385231
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33165867
60RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31946564
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31011521
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28828175
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26669024
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23642420
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.23128388
66* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21588331
67HTT_18923047_ChIP-ChIP_STHdh_Human1.19472798
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19151163
69PU_27001747_Chip-Seq_BMDM_Mouse1.16813030
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15779132
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13421530
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11996984
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10206624
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09999489
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.08626205
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06664541
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06471066
78NCOR1_26117541_ChIP-Seq_K562_Human1.06387824
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.06114967
80TAF2_19829295_ChIP-Seq_ESCs_Human1.03943218
81NANOG_20526341_ChIP-Seq_ESCs_Human1.02527789
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01961871
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.00092998
84VDR_22108803_ChIP-Seq_LS180_Human1.00000174
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99377386
86SA1_27219007_Chip-Seq_Bcells_Human0.99091161
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.98536416
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.98497564
89CTCF_20526341_ChIP-Seq_ESCs_Human0.97268980
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96559296
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95187650
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94651956
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.94134120
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93395401
95VDR_24787735_ChIP-Seq_THP-1_Human0.93254547
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92436114
97BCOR_27268052_Chip-Seq_Bcells_Human0.92328353
98P300_27268052_Chip-Seq_Bcells_Human0.92255258
99GATA2_19941826_ChIP-Seq_K562_Human0.91845271
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91153886
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90440282
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88828107
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88576660
104GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87424691
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87106304
106LXR_22292898_ChIP-Seq_THP-1_Human0.87083280
107* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86352058
108GATA1_19941826_ChIP-Seq_K562_Human0.85881976
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85316890
110GATA3_26560356_Chip-Seq_TH1_Human0.82651874
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82531802
112FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80308144
113FOXA1_25329375_ChIP-Seq_VCAP_Human0.80308144
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79682166
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79557716
116EGR1_19032775_ChIP-ChIP_M12_Human0.79244356
117SPI1_20517297_ChIP-Seq_HL60_Human0.78717438
118GATA1_19941827_ChIP-Seq_MEL_Mouse0.78536707
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78168639
120EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77469943
121CIITA_25753668_ChIP-Seq_RAJI_Human0.77043431
122TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.76739756
123EST1_17652178_ChIP-ChIP_JURKAT_Human0.76577942
124AR_20517297_ChIP-Seq_VCAP_Human0.76024059
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75974038
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75942130
127SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75925353
128ERG_20517297_ChIP-Seq_VCAP_Human0.75026604
129E2F1_20622854_ChIP-Seq_HELA_Human0.73909876
130JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.73196603
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72514326
132NFE2_27457419_Chip-Seq_LIVER_Mouse0.72243931
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.70487251
134GATA3_21878914_ChIP-Seq_MCF-7_Human0.70346359
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69461255
136VDR_23849224_ChIP-Seq_CD4+_Human0.68990343
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68525361
138FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.68320962
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.67673805
140KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.67495034
141FOXP3_21729870_ChIP-Seq_TREG_Human0.67200621
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65428893
143ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64793058
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.63834436
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63242289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.05415591
2MP0006082_CNS_inflammation6.35529277
3MP0003763_abnormal_thymus_physiology4.14321074
4MP0001835_abnormal_antigen_presentation3.24746904
5MP0001800_abnormal_humoral_immune3.22301281
6MP0001873_stomach_inflammation3.19713433
7MP0009785_altered_susceptibility_to3.09908403
8* MP0002420_abnormal_adaptive_immunity2.89775062
9* MP0001819_abnormal_immune_cell2.85130303
10* MP0005025_abnormal_response_to2.81861426
11MP0000858_altered_metastatic_potential2.76340742
12MP0005000_abnormal_immune_tolerance2.72406368
13MP0002723_abnormal_immune_serum2.69527590
14MP0001790_abnormal_immune_system2.66927561
15MP0005387_immune_system_phenotype2.66927561
16MP0002398_abnormal_bone_marrow2.62807233
17MP0000685_abnormal_immune_system2.56986094
18MP0009333_abnormal_splenocyte_physiolog2.50733392
19* MP0003448_altered_tumor_morphology2.45587335
20MP0002452_abnormal_antigen_presenting2.44158227
21MP0003300_gastrointestinal_ulcer2.36258655
22MP0000703_abnormal_thymus_morphology2.36038625
23MP0000716_abnormal_immune_system2.32083682
24MP0010307_abnormal_tumor_latency2.28963113
25MP0002722_abnormal_immune_system2.15010044
26MP0004947_skin_inflammation2.09322534
27MP0002405_respiratory_system_inflammati2.07946781
28MP0003950_abnormal_plasma_membrane2.05688337
29MP0002006_tumorigenesis2.04121849
30MP0002132_abnormal_respiratory_system2.03291527
31MP0002166_altered_tumor_susceptibility1.93770171
32MP0000689_abnormal_spleen_morphology1.91341065
33MP0010155_abnormal_intestine_physiology1.90975518
34MP0002429_abnormal_blood_cell1.85821115
35MP0005464_abnormal_platelet_physiology1.84997674
36MP0003866_abnormal_defecation1.76651616
37MP0003724_increased_susceptibility_to1.75577306
38MP0002419_abnormal_innate_immunity1.71069575
39MP0001845_abnormal_inflammatory_respons1.69727040
40MP0002933_joint_inflammation1.65641466
41MP0002148_abnormal_hypersensitivity_rea1.64713081
42MP0003303_peritoneal_inflammation1.55454960
43MP0001851_eye_inflammation1.37508915
44MP0003436_decreased_susceptibility_to1.37439757
45MP0008469_abnormal_protein_level1.35533168
46MP0002396_abnormal_hematopoietic_system1.32332004
47MP0002019_abnormal_tumor_incidence1.27689746
48MP0005310_abnormal_salivary_gland1.26173459
49MP0003045_fibrosis1.21247160
50MP0002277_abnormal_respiratory_mucosa1.18356651
51MP0000490_abnormal_crypts_of1.17216914
52MP0003646_muscle_fatigue1.10736445
53MP0005166_decreased_susceptibility_to1.10388450
54MP0004808_abnormal_hematopoietic_stem1.09455622
55MP0000920_abnormal_myelination1.06653928
56MP0009764_decreased_sensitivity_to1.05037487
57MP0010352_gastrointestinal_tract_polyps1.01115033
58MP0005377_hearing/vestibular/ear_phenot1.00686297
59MP0003878_abnormal_ear_physiology1.00686297
60MP0002998_abnormal_bone_remodeling1.00557900
61MP0003786_premature_aging0.97480663
62MP0005645_abnormal_hypothalamus_physiol0.96233149
63MP0001919_abnormal_reproductive_system0.96221311
64MP0001853_heart_inflammation0.95932956
65MP0001533_abnormal_skeleton_physiology0.93458413
66MP0003806_abnormal_nucleotide_metabolis0.93294766
67MP0003172_abnormal_lysosome_physiology0.87194696
68* MP0009763_increased_sensitivity_to0.85183342
69MP0004510_myositis0.81241999
70MP0003566_abnormal_cell_adhesion0.79294338
71MP0008873_increased_physiological_sensi0.79038048
72MP0005397_hematopoietic_system_phenotyp0.78147238
73MP0001545_abnormal_hematopoietic_system0.78147238
74MP0000465_gastrointestinal_hemorrhage0.77720861
75MP0005083_abnormal_biliary_tract0.74369506
76MP0008057_abnormal_DNA_replication0.74338870
77MP0002163_abnormal_gland_morphology0.73787799
78MP0003137_abnormal_impulse_conducting0.72114102
79MP0008872_abnormal_physiological_respon0.72016110
80MP0001905_abnormal_dopamine_level0.71919301
81MP0002876_abnormal_thyroid_physiology0.71476395
82MP0005023_abnormal_wound_healing0.70865033
83MP0002102_abnormal_ear_morphology0.69444700
84MP0004145_abnormal_muscle_electrophysio0.67460269
85MP0004957_abnormal_blastocyst_morpholog0.67232720
86MP0001986_abnormal_taste_sensitivity0.65704875
87MP0003075_altered_response_to0.63760534
88MP0001663_abnormal_digestive_system0.62751880
89MP0003690_abnormal_glial_cell0.62643240
90MP0002138_abnormal_hepatobiliary_system0.62419647
91MP0005584_abnormal_enzyme/coenzyme_acti0.60166840
92MP0001542_abnormal_bone_strength0.59226884
93MP0001765_abnormal_ion_homeostasis0.58569813
94MP0000609_abnormal_liver_physiology0.58472124
95MP0006072_abnormal_retinal_apoptosis0.58362272
96MP0005389_reproductive_system_phenotype0.57579084
97MP0004883_abnormal_blood_vessel0.56941456
98MP0002009_preneoplasia0.56820734
99MP0002168_other_aberrant_phenotype0.54767425
100MP0003252_abnormal_bile_duct0.53837589
101MP0000343_altered_response_to0.53646408
102MP0005319_abnormal_enzyme/_coenzyme0.52310307
103MP0000477_abnormal_intestine_morphology0.52090287
104MP0010234_abnormal_vibrissa_follicle0.51686947
105MP0002693_abnormal_pancreas_physiology0.50288122
106MP0003693_abnormal_embryo_hatching0.50209348
107MP0002736_abnormal_nociception_after0.48877993
108MP0001968_abnormal_touch/_nociception0.48539108
109MP0002095_abnormal_skin_pigmentation0.48025296
110MP0000613_abnormal_salivary_gland0.47307121
111MP0001485_abnormal_pinna_reflex0.47236855
112MP0003795_abnormal_bone_structure0.47068794
113MP0006054_spinal_hemorrhage0.46904527
114MP0004381_abnormal_hair_follicle0.46261371
115MP0005076_abnormal_cell_differentiation0.45572310
116MP0004130_abnormal_muscle_cell0.45520322
117MP0009765_abnormal_xenobiotic_induced0.45160989
118MP0002638_abnormal_pupillary_reflex0.45070417
119MP0005390_skeleton_phenotype0.44644202
120MP0003279_aneurysm0.44352456
121MP0005636_abnormal_mineral_homeostasis0.43824262
122MP0001501_abnormal_sleep_pattern0.43691718
123MP0000249_abnormal_blood_vessel0.43196975
124MP0001119_abnormal_female_reproductive0.42849205
125MP0002083_premature_death0.42494352
126MP0008875_abnormal_xenobiotic_pharmacok0.42242482
127MP0009642_abnormal_blood_homeostasis0.41670996
128MP0001191_abnormal_skin_condition0.41562051
129MP0002086_abnormal_extraembryonic_tissu0.41071364
130MP0002136_abnormal_kidney_physiology0.40907992
131MP0005360_urolithiasis0.39694458
132MP0003329_amyloid_beta_deposits0.37057877
133MP0008770_decreased_survivor_rate0.36649854
134MP0003943_abnormal_hepatobiliary_system0.34235903
135MP0000604_amyloidosis0.33504528
136MP0000367_abnormal_coat/_hair0.32766723
137MP0009643_abnormal_urine_homeostasis0.32299613
138MP0001243_abnormal_dermal_layer0.31416555
139MP0009384_cardiac_valve_regurgitation0.31139243
140MP0005075_abnormal_melanosome_morpholog0.29819105
141MP0009278_abnormal_bone_marrow0.28968047

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)7.01480585
2T lymphocytopenia (HP:0005403)6.52935060
3Encephalitis (HP:0002383)6.46107415
4Hemiplegia (HP:0002301)6.22696353
5Abnormality of T cell number (HP:0011839)6.22415803
6Optic neuritis (HP:0100653)6.06405996
7Retrobulbar optic neuritis (HP:0100654)6.06405996
8Myositis (HP:0100614)5.85936801
9Hypoproteinemia (HP:0003075)5.81246719
10Nasal polyposis (HP:0100582)5.66458821
11Orchitis (HP:0100796)5.38447490
12Keratoconjunctivitis sicca (HP:0001097)4.70528838
13Abnormality of the nasal mucosa (HP:0000433)4.60779927
14Meningitis (HP:0001287)4.56882612
15Tetraplegia (HP:0002445)4.56405714
16Abnormality of macrophages (HP:0004311)4.50552935
17Joint swelling (HP:0001386)4.49515159
18Increased serum ferritin (HP:0003281)4.35703693
19Abnormality of the common coagulation pathway (HP:0010990)4.33389328
20Keratoconjunctivitis (HP:0001096)4.23995407
21Abnormality of T cells (HP:0002843)4.05554244
22Chronic diarrhea (HP:0002028)4.00090666
23Stomatitis (HP:0010280)3.89605183
24Increased CSF protein (HP:0002922)3.70809484
25Pulmonary embolism (HP:0002204)3.64979798
26Abnormality of iron homeostasis (HP:0011031)3.60118996
27Thyroiditis (HP:0100646)3.48477747
28Abnormal albumin level (HP:0012116)3.42101983
29Hypoalbuminemia (HP:0003073)3.42101983
30Acute hepatic failure (HP:0006554)3.37079588
31Pulmonary infiltrates (HP:0002113)3.35905135
32Arterial thrombosis (HP:0004420)3.27509346
33IgM deficiency (HP:0002850)3.23097198
34Gangrene (HP:0100758)3.18525765
35Hemoptysis (HP:0002105)3.14043801
36Vasculitis (HP:0002633)3.13138257
37Elevated erythrocyte sedimentation rate (HP:0003565)3.11666900
38Combined immunodeficiency (HP:0005387)3.09697825
39Abnormality of B cell number (HP:0010975)3.09004422
40Recurrent viral infections (HP:0004429)3.08098423
41Chronic mucocutaneous candidiasis (HP:0002728)3.07158678
42Recurrent cutaneous fungal infections (HP:0011370)3.07158678
43Pancytopenia (HP:0001876)3.06532597
44Severe combined immunodeficiency (HP:0004430)3.03357455
45Abnormality of transition element cation homeostasis (HP:0011030)3.02334217
46Spontaneous hematomas (HP:0007420)3.01783405
47Obstructive lung disease (HP:0006536)2.99177659
48Chronic obstructive pulmonary disease (HP:0006510)2.99177659
49Recurrent abscess formation (HP:0002722)2.98227659
50Abnormality of oral frenula (HP:0000190)2.97430736
51Amyotrophic lateral sclerosis (HP:0007354)2.95392365
52Recurrent bronchitis (HP:0002837)2.94743194
53Chronic otitis media (HP:0000389)2.90825854
54Ureteral stenosis (HP:0000071)2.88905154
55B lymphocytopenia (HP:0010976)2.87268214
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.86950331
57Eczematoid dermatitis (HP:0000976)2.85766422
58Hyponatremia (HP:0002902)2.77961110
59Recurrent bacterial skin infections (HP:0005406)2.74781446
60Increased intracranial pressure (HP:0002516)2.73205294
61Abnormality of intracranial pressure (HP:0012640)2.73205294
62Recurrent fungal infections (HP:0002841)2.70305483
63Abnormality of the fingertips (HP:0001211)2.67398634
64Inflammation of the large intestine (HP:0002037)2.64144143
65Increased intramyocellular lipid droplets (HP:0012240)2.61794231
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.61447301
67Gastrointestinal inflammation (HP:0004386)2.60697942
68Increased IgM level (HP:0003496)2.60378894
69Ureteral obstruction (HP:0006000)2.59696650
70Chest pain (HP:0100749)2.58575895
71Eosinophilia (HP:0001880)2.57292980
72Lymphoma (HP:0002665)2.56212115
73Hypoplasia of the thymus (HP:0000778)2.55196218
74Anorexia (HP:0002039)2.54604657
75Leukocytosis (HP:0001974)2.54490142
76Pustule (HP:0200039)2.52427250
77Bilateral sensorineural hearing impairment (HP:0008619)2.52303021
78Recurrent skin infections (HP:0001581)2.47969995
79Hypertriglyceridemia (HP:0002155)2.46620429
80Abnormality of the prostate (HP:0008775)2.45067609
81Epistaxis (HP:0000421)2.43967367
82IgG deficiency (HP:0004315)2.43720364
83Increased IgE level (HP:0003212)2.42184614
84Gastrointestinal infarctions (HP:0005244)2.40967461
85Glomerulopathy (HP:0100820)2.39391192
86Abnormal platelet volume (HP:0011876)2.39054679
87Abnormality of eosinophils (HP:0001879)2.38881700
88Mitochondrial inheritance (HP:0001427)2.35384962
89Bronchitis (HP:0012387)2.34582518
90Panhypogammaglobulinemia (HP:0003139)2.33649575
91Recurrent otitis media (HP:0000403)2.30027316
92Prolonged bleeding time (HP:0003010)2.27841486
93Abnormality of the pleura (HP:0002103)2.27300147
94Agammaglobulinemia (HP:0004432)2.26254046
95Cellular immunodeficiency (HP:0005374)2.22710081
96Cerebral palsy (HP:0100021)2.21421194
97Autoimmune hemolytic anemia (HP:0001890)2.21072427
98Congenital stationary night blindness (HP:0007642)2.19619629
99Polyneuropathy (HP:0001271)2.17854878
100Keratitis (HP:0000491)2.17693938
101Periodontitis (HP:0000704)2.17182794
102Recurrent gram-negative bacterial infections (HP:0005420)2.16753531
103Abnormality of sodium homeostasis (HP:0010931)2.15804983
104Autoimmune thrombocytopenia (HP:0001973)2.13896283
105Granulocytopenia (HP:0001913)2.13805358
106Increased muscle lipid content (HP:0009058)2.13506674
107Abnormal rod and cone electroretinograms (HP:0008323)2.10789841
108Trigonocephaly (HP:0000243)2.08494497
109Lymphopenia (HP:0001888)2.07851649
110Increased hepatocellular lipid droplets (HP:0006565)2.06866796
111Thrombophlebitis (HP:0004418)2.05682751
112Abnormality of T cell physiology (HP:0011840)2.05657078
113Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05643832
114Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05643832
115Hypergammaglobulinemia (HP:0010702)2.04456212
116Abnormality of the pericardium (HP:0001697)2.03988131
117Abnormality of cells of the lymphoid lineage (HP:0012140)2.00305287
118Increased density of long bones (HP:0006392)1.99660678
1193-Methylglutaconic aciduria (HP:0003535)1.95944473
120Renal Fanconi syndrome (HP:0001994)1.95830027
121Arthralgia (HP:0002829)1.95706682
122Increased mean platelet volume (HP:0011877)1.95152272
123Oral leukoplakia (HP:0002745)1.95111483
124Gingival bleeding (HP:0000225)1.92599960
125Acute necrotizing encephalopathy (HP:0006965)1.83818449
126Bronchiectasis (HP:0002110)1.83546014
127Abnormal mitochondria in muscle tissue (HP:0008316)1.81097031
128Purpura (HP:0000979)1.78536507
129Skin rash (HP:0000988)1.77479954
130Erythema (HP:0010783)1.77377381
131Diplopia (HP:0000651)1.77326990
132Abnormality of binocular vision (HP:0011514)1.77326990
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75562231
134Papilloma (HP:0012740)1.75251547
135Verrucae (HP:0200043)1.75251547
136Generalized aminoaciduria (HP:0002909)1.74976685
137Spondylolisthesis (HP:0003302)1.74257765
138Mediastinal lymphadenopathy (HP:0100721)1.74165614
139Radial bowing (HP:0002986)1.73520511
140Abnormal foot bone ossification (HP:0010675)1.72951372
141Lipid accumulation in hepatocytes (HP:0006561)1.66230478
142Hepatocellular necrosis (HP:0001404)1.64121669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.76317576
2MAP4K14.16635808
3ITK3.22832693
4JAK13.08635282
5STK103.08393662
6GRK72.93800381
7JAK32.73434205
8MST42.42552875
9ZAP702.33906299
10TESK22.25178320
11CSK1.93918879
12FES1.89391724
13TYK21.87921028
14LCK1.72731753
15VRK21.69005876
16GRK61.67819369
17CLK11.60062412
18ADRBK21.55793142
19BCKDK1.52522038
20PRKCH1.51103883
21MAP3K111.47847116
22SCYL21.45086965
23MAP3K101.44080535
24LRRK21.41162992
25TRIB31.37344594
26SYK1.36604163
27ZAK1.35041688
28EPHB11.27971036
29PRKCQ1.27284720
30CDC71.25175474
31RIPK41.19779527
32KDR1.16573699
33TLK11.14332557
34TNK21.14048218
35RIPK11.11806451
36TTN1.10675920
37BTK1.03701027
38VRK11.02357843
39PIK3CA1.01583237
40DMPK1.00948910
41BLK1.00392528
42CDK40.99817925
43FGFR40.95828589
44MAPKAPK30.93674940
45MAP3K140.93534478
46FGFR30.91410604
47PIM10.91408478
48TAOK30.88429300
49EEF2K0.87559403
50MYLK0.86857076
51TYRO30.85930529
52HCK0.84881172
53DAPK10.81075528
54JAK20.80759193
55SIK20.80559716
56STK240.76161065
57ALK0.76014202
58GRK10.75493515
59TBK10.72020583
60MARK30.68783058
61BUB10.66744021
62IKBKE0.63257966
63WNK40.61943370
64LYN0.61570092
65ROCK10.60912144
66PDGFRB0.60149295
67NUAK10.60042953
68TEC0.58273466
69NEK20.55835159
70MUSK0.55138970
71CSF1R0.54142047
72GRK50.54019578
73MAP2K60.53082262
74BMPR20.52747371
75RPS6KA40.51092525
76MAP4K20.50483925
77FYN0.50332391
78PIK3CG0.49909884
79TESK10.48903072
80MAP3K70.48735329
81CDK120.48557294
82MELK0.48414277
83CDK90.48115339
84INSR0.45839218
85ILK0.44664311
86FRK0.43577183
87TGFBR20.43511627
88IGF1R0.41146556
89HIPK20.40090474
90KIT0.39460855
91PAK10.38141319
92MAP3K80.37698633
93PDK10.36519471
94EPHA30.35704136
95NLK0.35588048
96PTK60.35553324
97FGR0.35164758
98AURKA0.34799886
99CDK60.33821422
100IRAK40.32956282
101MAP3K50.32861249
102MAP3K120.32531156
103PTK20.32080717
104CAMKK20.31173840
105PASK0.31007773
106PRKCA0.30760933
107ADRBK10.30560645
108OBSCN0.30346307
109PRKG20.30261535
110INSRR0.29090982
111RPS6KA50.28007938
112GSK3A0.27982835
113TRPM70.26847544
114STK160.26523461
115BMX0.25917451
116EIF2AK30.25666506
117TIE10.25348126
118RPS6KA60.24106266
119PAK40.24021054
120ROCK20.23245032
121STK40.22744582
122RAF10.22603660
123RPS6KL10.22489764
124RPS6KC10.22489764
125CSNK1A1L0.22087960
126MAPK110.21572791
127CDK80.21510277
128STK390.21098778
129ABL10.20615354
130OXSR10.19654418
131PRKCD0.19445226
132MAPK130.19073726
133SRC0.18547923
134PKN20.18410408
135IKBKB0.18230984
136PRKACA0.17324160
137MAPK120.17177018
138MAPKAPK20.16769976
139CSNK1G30.16309308
140PRKCB0.16119119
141ACVR1B0.16101025
142MAPK40.15710117
143LIMK10.15642307
144MAPK70.14888073

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053328.43616520
2Allograft rejection_Homo sapiens_hsa053305.67616871
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046505.05875710
4Autoimmune thyroid disease_Homo sapiens_hsa053204.65662265
5Proteasome_Homo sapiens_hsa030503.57339800
6Antigen processing and presentation_Homo sapiens_hsa046123.29544009
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.14911719
8Type I diabetes mellitus_Homo sapiens_hsa049403.13328101
9Viral myocarditis_Homo sapiens_hsa054162.71501172
10Primary immunodeficiency_Homo sapiens_hsa053402.42863480
11T cell receptor signaling pathway_Homo sapiens_hsa046602.33010057
12Oxidative phosphorylation_Homo sapiens_hsa001902.24889759
13Parkinsons disease_Homo sapiens_hsa050121.94733077
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.85750389
15Measles_Homo sapiens_hsa051621.67246115
16Leishmaniasis_Homo sapiens_hsa051401.66736444
17Staphylococcus aureus infection_Homo sapiens_hsa051501.56038228
18Malaria_Homo sapiens_hsa051441.46375694
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41647085
20Alzheimers disease_Homo sapiens_hsa050101.35854339
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.34587412
22Asthma_Homo sapiens_hsa053101.22573949
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.13914686
24Hematopoietic cell lineage_Homo sapiens_hsa046401.08862473
25Apoptosis_Homo sapiens_hsa042101.07812130
26Cardiac muscle contraction_Homo sapiens_hsa042601.06188087
27Huntingtons disease_Homo sapiens_hsa050161.00558098
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00104804
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98105960
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98085434
31Osteoclast differentiation_Homo sapiens_hsa043800.97590166
32B cell receptor signaling pathway_Homo sapiens_hsa046620.97272363
33Toxoplasmosis_Homo sapiens_hsa051450.90893354
34Shigellosis_Homo sapiens_hsa051310.88921250
35RNA polymerase_Homo sapiens_hsa030200.87688522
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.85084959
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84856159
38Chemokine signaling pathway_Homo sapiens_hsa040620.84825871
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84098269
40Phototransduction_Homo sapiens_hsa047440.83846100
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83529766
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83232675
43Pertussis_Homo sapiens_hsa051330.82300223
44Platelet activation_Homo sapiens_hsa046110.78690218
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77407720
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73741411
47Pancreatic cancer_Homo sapiens_hsa052120.72661628
48HTLV-I infection_Homo sapiens_hsa051660.69122024
49Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69011321
50Hepatitis B_Homo sapiens_hsa051610.67321266
51Nitrogen metabolism_Homo sapiens_hsa009100.62498001
52Colorectal cancer_Homo sapiens_hsa052100.56651360
53Systemic lupus erythematosus_Homo sapiens_hsa053220.56505895
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55501431
55Tuberculosis_Homo sapiens_hsa051520.54507375
56VEGF signaling pathway_Homo sapiens_hsa043700.53531335
57Protein export_Homo sapiens_hsa030600.52758213
58Linoleic acid metabolism_Homo sapiens_hsa005910.52313345
59DNA replication_Homo sapiens_hsa030300.52241117
60Herpes simplex infection_Homo sapiens_hsa051680.51280862
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49699237
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49422704
63Legionellosis_Homo sapiens_hsa051340.48662210
64Chronic myeloid leukemia_Homo sapiens_hsa052200.46780198
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45580232
66Salmonella infection_Homo sapiens_hsa051320.45282347
67* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44946958
68Renal cell carcinoma_Homo sapiens_hsa052110.43897191
69Influenza A_Homo sapiens_hsa051640.43817766
70Acute myeloid leukemia_Homo sapiens_hsa052210.43697620
71Epstein-Barr virus infection_Homo sapiens_hsa051690.42632321
72Peroxisome_Homo sapiens_hsa041460.40776455
73Endocytosis_Homo sapiens_hsa041440.40679148
74TNF signaling pathway_Homo sapiens_hsa046680.40466196
75Olfactory transduction_Homo sapiens_hsa047400.39423871
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39260503
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38919041
78Rheumatoid arthritis_Homo sapiens_hsa053230.38671564
79Non-small cell lung cancer_Homo sapiens_hsa052230.38489676
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38479645
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34387171
82Rap1 signaling pathway_Homo sapiens_hsa040150.34029793
83Regulation of autophagy_Homo sapiens_hsa041400.33884912
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.33166065
85Viral carcinogenesis_Homo sapiens_hsa052030.33013154
86Focal adhesion_Homo sapiens_hsa045100.32906947
87Hepatitis C_Homo sapiens_hsa051600.30907585
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30278672
89Retinol metabolism_Homo sapiens_hsa008300.27945397
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.26344793
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.25522928
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25003489
93Non-homologous end-joining_Homo sapiens_hsa034500.24367269
94Amoebiasis_Homo sapiens_hsa051460.24274519
95Mineral absorption_Homo sapiens_hsa049780.23902855
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23520933
97Mismatch repair_Homo sapiens_hsa034300.23158310
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23054781
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22824246
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.22512812
101Ribosome_Homo sapiens_hsa030100.21234478
102Pyrimidine metabolism_Homo sapiens_hsa002400.21179852
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20877984
104Small cell lung cancer_Homo sapiens_hsa052220.19631652
105Chemical carcinogenesis_Homo sapiens_hsa052040.19415289
106Phagosome_Homo sapiens_hsa041450.18930653
107Purine metabolism_Homo sapiens_hsa002300.18408521
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17033822
109p53 signaling pathway_Homo sapiens_hsa041150.13703792
110Caffeine metabolism_Homo sapiens_hsa002320.13471449
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12712815
112Dilated cardiomyopathy_Homo sapiens_hsa054140.12625414
113FoxO signaling pathway_Homo sapiens_hsa040680.12181862
114African trypanosomiasis_Homo sapiens_hsa051430.11693915
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11469247
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11397772
117Prolactin signaling pathway_Homo sapiens_hsa049170.11345010
118Long-term potentiation_Homo sapiens_hsa047200.11318983
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10246718
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10140159
121ABC transporters_Homo sapiens_hsa020100.08629356
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.08288712
123Spliceosome_Homo sapiens_hsa030400.08184756
124Renin secretion_Homo sapiens_hsa049240.06884777
125Notch signaling pathway_Homo sapiens_hsa043300.06209651
126Proteoglycans in cancer_Homo sapiens_hsa052050.05670634
127MicroRNAs in cancer_Homo sapiens_hsa052060.05373417
128Homologous recombination_Homo sapiens_hsa034400.04416788
129Cell cycle_Homo sapiens_hsa041100.04195630
130MAPK signaling pathway_Homo sapiens_hsa040100.04172157
131Amphetamine addiction_Homo sapiens_hsa050310.03562778
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.03538373
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03336523
134Glioma_Homo sapiens_hsa052140.02923284
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.02451153
136Adherens junction_Homo sapiens_hsa045200.02243077
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.01944769
138Endometrial cancer_Homo sapiens_hsa052130.01562040
139Sulfur metabolism_Homo sapiens_hsa009200.01101601
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.00885292
141Ras signaling pathway_Homo sapiens_hsa04014-0.0086348
142Prion diseases_Homo sapiens_hsa05020-0.0082254
143mTOR signaling pathway_Homo sapiens_hsa04150-0.0038304
144Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0027289
145Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0014719

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