GZMB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.99224596
2DNA deamination (GO:0045006)8.82462074
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.55569654
4cellular response to interleukin-15 (GO:0071350)8.42345364
5* cytolysis (GO:0019835)8.05389713
6response to interleukin-15 (GO:0070672)7.36701828
7regulation of natural killer cell mediated cytotoxicity (GO:0042269)7.35877182
8regulation of natural killer cell mediated immunity (GO:0002715)7.35877182
9activated T cell proliferation (GO:0050798)6.82414865
10positive regulation of gamma-delta T cell activation (GO:0046645)6.30436039
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.24825024
12positive regulation of natural killer cell mediated immunity (GO:0002717)6.24825024
13negative regulation by host of viral transcription (GO:0043922)6.01414364
14regulation of isotype switching to IgG isotypes (GO:0048302)5.79632907
15positive regulation of isotype switching (GO:0045830)5.78455837
16cellular defense response (GO:0006968)5.60508728
17regulation of leukocyte mediated cytotoxicity (GO:0001910)5.41084342
18negative regulation of cell killing (GO:0031342)5.32464139
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.32464139
20positive regulation of B cell mediated immunity (GO:0002714)5.26236651
21positive regulation of immunoglobulin mediated immune response (GO:0002891)5.26236651
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.23704750
23regulation of cell killing (GO:0031341)5.14181556
24T cell migration (GO:0072678)5.08854453
25positive regulation of lymphocyte migration (GO:2000403)5.08315707
26regulation of gamma-delta T cell differentiation (GO:0045586)5.03759770
27negative T cell selection (GO:0043383)5.02458101
28positive thymic T cell selection (GO:0045059)4.95155799
29positive regulation of cell killing (GO:0031343)4.92407751
30negative thymic T cell selection (GO:0045060)4.88661419
31positive regulation of DNA recombination (GO:0045911)4.88232130
32lymphocyte chemotaxis (GO:0048247)4.83557397
33regulation of response to tumor cell (GO:0002834)4.71338802
34positive regulation of response to tumor cell (GO:0002836)4.71338802
35positive regulation of immune response to tumor cell (GO:0002839)4.71338802
36regulation of immune response to tumor cell (GO:0002837)4.71338802
37eosinophil chemotaxis (GO:0048245)4.69391112
38regulation of interleukin-12 biosynthetic process (GO:0045075)4.68822291
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.67260477
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.67260477
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.56684157
42pyrimidine nucleoside catabolic process (GO:0046135)4.42177920
43negative regulation of viral genome replication (GO:0045071)4.40978401
44tyrosine phosphorylation of STAT protein (GO:0007260)4.39455154
45regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36828551
46regulation of gamma-delta T cell activation (GO:0046643)4.35599359
47natural killer cell activation (GO:0030101)4.35266912
48response to protozoan (GO:0001562)4.26848551
49leukocyte aggregation (GO:0070486)4.26735542
50regulation of lymphocyte chemotaxis (GO:1901623)4.26610336
51regulation of isotype switching (GO:0045191)4.23787074
52positive T cell selection (GO:0043368)4.23190924
53regulation of regulatory T cell differentiation (GO:0045589)4.22503485
54eosinophil migration (GO:0072677)4.22098501
55positive regulation of lymphocyte mediated immunity (GO:0002708)4.21826417
56positive regulation of interleukin-8 secretion (GO:2000484)4.19791749
57regulation of chronic inflammatory response (GO:0002676)4.19558745
58positive regulation of calcium-mediated signaling (GO:0050850)4.17823764
59regulation of immunoglobulin mediated immune response (GO:0002889)4.14720599
60defense response to protozoan (GO:0042832)4.11289367
61thymic T cell selection (GO:0045061)4.08400126
62regulation of B cell mediated immunity (GO:0002712)4.04418839
63positive regulation of immunoglobulin production (GO:0002639)4.00491795
64mast cell activation (GO:0045576)3.96008429
65regulation of lymphocyte mediated immunity (GO:0002706)3.91488917
66regulation of lymphocyte migration (GO:2000401)3.82022354
67regulation of RIG-I signaling pathway (GO:0039535)3.81244009
68regulation of response to interferon-gamma (GO:0060330)3.79676124
69negative regulation of viral transcription (GO:0032897)3.79529112
70antigen processing and presentation of endogenous antigen (GO:0019883)3.75497036
71regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.75059177
72modulation by host of symbiont transcription (GO:0052472)3.75040980
73modulation by host of viral transcription (GO:0043921)3.75040980
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.73154981
75T cell proliferation (GO:0042098)3.69990231
76macrophage chemotaxis (GO:0048246)3.69045208
77negative regulation of T cell apoptotic process (GO:0070233)3.69021121
78positive regulation of T-helper 1 type immune response (GO:0002827)3.68376736
79regulation of B cell differentiation (GO:0045577)3.68194979
80positive regulation of T cell cytokine production (GO:0002726)3.66332155
81alpha-beta T cell differentiation involved in immune response (GO:0002293)3.60849670
82alpha-beta T cell activation involved in immune response (GO:0002287)3.60849670
83T cell differentiation involved in immune response (GO:0002292)3.60849670
84positive regulation of leukocyte mediated immunity (GO:0002705)3.60220001
85lymphocyte migration (GO:0072676)3.59486389
86regulation of memory T cell differentiation (GO:0043380)3.58617212
87negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.57908783
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57284107
89positive regulation of humoral immune response (GO:0002922)3.54038987
90modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.53078158
91positive regulation of macrophage differentiation (GO:0045651)3.52157403
92myeloid dendritic cell differentiation (GO:0043011)3.50956146
93myeloid dendritic cell activation (GO:0001773)3.49384664
94positive regulation of T cell migration (GO:2000406)3.49195255
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48741538
96T cell receptor signaling pathway (GO:0050852)3.47556744
97T cell costimulation (GO:0031295)3.46105443
98regulation of alpha-beta T cell proliferation (GO:0046640)3.43643142
99regulation of B cell receptor signaling pathway (GO:0050855)3.42838670
100negative regulation of interleukin-12 production (GO:0032695)3.41442993
101positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.41242220
102T cell selection (GO:0045058)3.40761939
103thrombin receptor signaling pathway (GO:0070493)3.40052323
104lymphocyte costimulation (GO:0031294)3.39582629
105positive regulation of alpha-beta T cell proliferation (GO:0046641)3.39024417
106DNA demethylation (GO:0080111)3.34967875
107positive regulation of interferon-gamma production (GO:0032729)3.34682290
108NIK/NF-kappaB signaling (GO:0038061)3.34124674
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32627285
110negative regulation of viral process (GO:0048525)3.30872491
111regulation of T cell mediated cytotoxicity (GO:0001914)3.30539455
112negative regulation of interleukin-2 production (GO:0032703)3.29186872
113negative regulation of T cell mediated immunity (GO:0002710)3.27701553
114T cell homeostasis (GO:0043029)3.27308747
115regulation of immunoglobulin production (GO:0002637)3.26272447
116regulation of viral genome replication (GO:0045069)3.22991216
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22290778
118regulation of T cell chemotaxis (GO:0010819)3.21707487
119positive regulation of T cell chemotaxis (GO:0010820)3.21707487
120negative regulation of phagocytosis (GO:0050765)3.20326662
121regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.20316750
122regulation of leukocyte mediated immunity (GO:0002703)3.20254792
123regulation of T-helper 1 type immune response (GO:0002825)3.19485253
124positive regulation of B cell differentiation (GO:0045579)3.14744273
125alpha-beta T cell activation (GO:0046631)3.11561029
126regulation of chemokine-mediated signaling pathway (GO:0070099)3.11251047
127regulation of T cell tolerance induction (GO:0002664)3.09796339
128positive regulation of DNA-templated transcription, initiation (GO:2000144)3.06903611
129positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.06868285
130alpha-beta T cell differentiation (GO:0046632)3.06466238
131regulation of T cell migration (GO:2000404)3.06086257
132positive regulation of defense response to virus by host (GO:0002230)3.06000671
133positive regulation of tolerance induction (GO:0002645)3.04923696
134regulation of calcium-mediated signaling (GO:0050848)3.02308353
135Arp2/3 complex-mediated actin nucleation (GO:0034314)3.02139145
136mast cell activation involved in immune response (GO:0002279)3.01447916
137mast cell degranulation (GO:0043303)3.01447916
138dendritic cell chemotaxis (GO:0002407)3.00466966
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.00249997
140antigen receptor-mediated signaling pathway (GO:0050851)2.99874708
141citrulline biosynthetic process (GO:0019240)2.99717626
142regulation of hypersensitivity (GO:0002883)2.99076743
143negative regulation of B cell proliferation (GO:0030889)2.95805842
144regulation of interleukin-8 secretion (GO:2000482)2.95541410
145lymph node development (GO:0048535)2.94678752
146positive regulation of interleukin-1 beta secretion (GO:0050718)2.94280811
147negative regulation of T cell activation (GO:0050868)2.91302041
148interferon-gamma production (GO:0032609)11.6733706
149cytidine deamination (GO:0009972)10.9420200
150cytidine metabolic process (GO:0046087)10.9420200
151cytidine catabolic process (GO:0006216)10.9420200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.41854875
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.72182994
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.55479475
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.68486858
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.38608507
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.31966954
7MYB_26560356_Chip-Seq_TH2_Human3.40020177
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.31082454
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.28680361
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14697083
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14632335
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.12642383
13RUNX_20019798_ChIP-Seq_JUKART_Human3.12254570
14MYC_22102868_ChIP-Seq_BL_Human2.91103015
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87944852
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86340514
17MYB_26560356_Chip-Seq_TH1_Human2.78503268
18MAF_26560356_Chip-Seq_TH1_Human2.72554995
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.65326035
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.53345861
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44429278
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44323676
23UTX_26944678_Chip-Seq_JUKART_Human2.44230555
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30113181
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.28765735
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24222444
27VDR_21846776_ChIP-Seq_THP-1_Human2.16855759
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15520195
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.14191370
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.14185402
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.12859995
32IRF8_22096565_ChIP-ChIP_GC-B_Human2.00994396
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00733332
34TCF7_22412390_ChIP-Seq_EML_Mouse1.91152273
35GATA3_27048872_Chip-Seq_THYMUS_Human1.84616135
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82293165
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.82024749
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78534634
39MAF_26560356_Chip-Seq_TH2_Human1.77467433
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75102580
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.73746666
42SPI1_23547873_ChIP-Seq_NB4_Human1.73454634
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.72048352
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71311267
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70060439
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68606691
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64312019
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60793471
49VDR_24763502_ChIP-Seq_THP-1_Human1.58763902
50SCL_19346495_ChIP-Seq_HPC-7_Human1.57482792
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54647038
52KDM2B_26808549_Chip-Seq_DND41_Human1.53947881
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53465496
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53254885
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51929886
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50025994
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41979213
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39378495
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39153322
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36676751
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34730797
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30781137
63SPI1_23127762_ChIP-Seq_K562_Human1.27564415
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27377327
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25673301
66* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23956682
67GATA3_26560356_Chip-Seq_TH2_Human1.20630959
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20225185
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15618334
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15335719
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14536023
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09322702
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.08202221
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.07055705
75NCOR1_26117541_ChIP-Seq_K562_Human1.05577794
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01288840
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.00705526
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99966496
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99291765
80MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97836919
81VDR_22108803_ChIP-Seq_LS180_Human0.97796828
82EGR1_19032775_ChIP-ChIP_M12_Human0.96739638
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96035249
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95641350
85MYC_18555785_ChIP-Seq_MESCs_Mouse0.95402593
86VDR_23849224_ChIP-Seq_CD4+_Human0.95315106
87PU_27001747_Chip-Seq_BMDM_Mouse0.93929306
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93809015
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93595800
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92714114
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92337291
92GATA3_26560356_Chip-Seq_TH1_Human0.90955110
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.90095816
94LXR_22292898_ChIP-Seq_THP-1_Human0.88222743
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87295656
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87277523
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.87174403
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86512192
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86317683
100ETS1_20019798_ChIP-Seq_JURKAT_Human0.85553738
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.85202435
102SPI1_20517297_ChIP-Seq_HL60_Human0.84648790
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84626023
104IRF1_19129219_ChIP-ChIP_H3396_Human0.82793299
105GATA1_19941826_ChIP-Seq_K562_Human0.82294341
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82113174
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81785721
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.81270737
109E2F1_21310950_ChIP-Seq_MCF-7_Human0.81257110
110VDR_24787735_ChIP-Seq_THP-1_Human0.81066718
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80615354
112EZH2_27294783_Chip-Seq_NPCs_Mouse0.80038713
113GATA6_21074721_ChIP-Seq_CACO-2_Human0.79926456
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79900266
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79582395
116GATA2_19941826_ChIP-Seq_K562_Human0.77753719
117TAF2_19829295_ChIP-Seq_ESCs_Human0.77440797
118CIITA_25753668_ChIP-Seq_RAJI_Human0.76967837
119TP53_22573176_ChIP-Seq_HFKS_Human0.76316142
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76204312
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75556965
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74931461
123PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74758423
124FOXH1_21741376_ChIP-Seq_EPCs_Human0.74695959
125* HTT_18923047_ChIP-ChIP_STHdh_Human0.74498722
126STAT1_20625510_ChIP-Seq_HELA_Human0.74470249
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72982616
128FOXP3_21729870_ChIP-Seq_TREG_Human0.72014365
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.71837719
130* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71256516
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.71053398
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.70174888
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.70174888
134* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70104730
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69976861
136RBPJ_21746931_ChIP-Seq_IB4_Human0.69167585
137ELF5_23300383_ChIP-Seq_T47D_Human0.69127131
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.69061504
139BCL6_27268052_Chip-Seq_Bcells_Human0.68894789
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.68868163
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.68536424
142ZNF274_21170338_ChIP-Seq_K562_Hela0.68182626
143GATA3_21878914_ChIP-Seq_MCF-7_Human0.67618943
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67396543
145GATA1_22025678_ChIP-Seq_K562_Human0.66254187
146RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65396180
147CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.65134810
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.65112708
149NANOG_20526341_ChIP-Seq_ESCs_Human0.64615959
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.64262654
151ELK1_19687146_ChIP-ChIP_HELA_Human0.63488540
152MYC_19829295_ChIP-Seq_ESCs_Human0.62832644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to8.42079248
2MP0006082_CNS_inflammation6.51600190
3MP0010307_abnormal_tumor_latency3.65201382
4MP0001835_abnormal_antigen_presentation3.33649922
5MP0003763_abnormal_thymus_physiology3.24522649
6MP0009333_abnormal_splenocyte_physiolog3.03562618
7MP0001800_abnormal_humoral_immune3.00961860
8MP0000569_abnormal_digit_pigmentation2.96354095
9MP0003300_gastrointestinal_ulcer2.86794473
10MP0009785_altered_susceptibility_to2.77033428
11MP0005025_abnormal_response_to2.70488625
12MP0005000_abnormal_immune_tolerance2.64770408
13MP0002723_abnormal_immune_serum2.58783790
14* MP0002420_abnormal_adaptive_immunity2.57596732
15* MP0003448_altered_tumor_morphology2.54220447
16* MP0001819_abnormal_immune_cell2.52400084
17MP0002398_abnormal_bone_marrow2.41681121
18MP0001873_stomach_inflammation2.31927322
19MP0003950_abnormal_plasma_membrane2.24837804
20MP0002452_abnormal_antigen_presenting2.17407060
21MP0000703_abnormal_thymus_morphology2.09076326
22* MP0000716_abnormal_immune_system2.05973072
23MP0002405_respiratory_system_inflammati2.03544924
24MP0002722_abnormal_immune_system2.03423329
25MP0010155_abnormal_intestine_physiology1.98197609
26MP0000858_altered_metastatic_potential1.96039882
27MP0000689_abnormal_spleen_morphology1.88266427
28* MP0005387_immune_system_phenotype1.85908273
29* MP0001790_abnormal_immune_system1.85908273
30MP0005464_abnormal_platelet_physiology1.77622118
31MP0003866_abnormal_defecation1.77193631
32* MP0002429_abnormal_blood_cell1.70467944
33MP0002006_tumorigenesis1.70124850
34MP0003436_decreased_susceptibility_to1.67048812
35MP0002138_abnormal_hepatobiliary_system1.64206492
36MP0001845_abnormal_inflammatory_respons1.61934799
37MP0002396_abnormal_hematopoietic_system1.57622097
38MP0002148_abnormal_hypersensitivity_rea1.56919724
39MP0004947_skin_inflammation1.54951280
40MP0000372_irregular_coat_pigmentation1.53803002
41MP0002419_abnormal_innate_immunity1.51446702
42MP0000685_abnormal_immune_system1.51323466
43MP0002166_altered_tumor_susceptibility1.50718664
44MP0001851_eye_inflammation1.49758165
45MP0004510_myositis1.45950957
46MP0002163_abnormal_gland_morphology1.42467752
47MP0000490_abnormal_crypts_of1.42143949
48MP0008469_abnormal_protein_level1.41026122
49MP0003724_increased_susceptibility_to1.39735605
50MP0001958_emphysema1.39507119
51MP0008057_abnormal_DNA_replication1.39096715
52MP0004808_abnormal_hematopoietic_stem1.32603744
53MP0005360_urolithiasis1.30815432
54MP0002132_abnormal_respiratory_system1.26489269
55MP0003303_peritoneal_inflammation1.20628168
56MP0000465_gastrointestinal_hemorrhage1.19656096
57MP0002019_abnormal_tumor_incidence1.19319643
58MP0003693_abnormal_embryo_hatching1.17390738
59MP0002277_abnormal_respiratory_mucosa1.16993861
60MP0001501_abnormal_sleep_pattern1.15486066
61MP0005166_decreased_susceptibility_to1.12657865
62MP0000343_altered_response_to1.11478991
63* MP0009763_increased_sensitivity_to1.11385267
64MP0005174_abnormal_tail_pigmentation1.10445999
65MP0003183_abnormal_peptide_metabolism1.07482255
66MP0005310_abnormal_salivary_gland1.05216104
67MP0000920_abnormal_myelination1.05199069
68MP0001502_abnormal_circadian_rhythm1.04279234
69MP0004145_abnormal_muscle_electrophysio0.99946978
70MP0000015_abnormal_ear_pigmentation0.99759762
71MP0000604_amyloidosis0.93834426
72MP0001853_heart_inflammation0.93508540
73MP0001533_abnormal_skeleton_physiology0.91600941
74MP0002095_abnormal_skin_pigmentation0.90645918
75MP0003172_abnormal_lysosome_physiology0.88381122
76MP0008873_increased_physiological_sensi0.88183402
77MP0001919_abnormal_reproductive_system0.88150121
78MP0003786_premature_aging0.88003249
79MP0002998_abnormal_bone_remodeling0.87628272
80MP0004957_abnormal_blastocyst_morpholog0.84577716
81MP0002877_abnormal_melanocyte_morpholog0.84136141
82MP0005319_abnormal_enzyme/_coenzyme0.83413459
83MP0001545_abnormal_hematopoietic_system0.80345856
84MP0005397_hematopoietic_system_phenotyp0.80345856
85MP0005379_endocrine/exocrine_gland_phen0.79512074
86MP0002933_joint_inflammation0.79507169
87MP0010234_abnormal_vibrissa_follicle0.78427946
88MP0010352_gastrointestinal_tract_polyps0.76817229
89MP0002876_abnormal_thyroid_physiology0.74094546
90MP0003329_amyloid_beta_deposits0.73903669
91MP0002254_reproductive_system_inflammat0.73679711
92MP0003878_abnormal_ear_physiology0.73670271
93MP0005377_hearing/vestibular/ear_phenot0.73670271
94MP0003566_abnormal_cell_adhesion0.70097560
95MP0005165_increased_susceptibility_to0.69984028
96MP0000609_abnormal_liver_physiology0.67850916
97MP0004742_abnormal_vestibular_system0.65806742
98MP0000627_abnormal_mammary_gland0.64744911
99MP0005410_abnormal_fertilization0.64561556
100MP0003943_abnormal_hepatobiliary_system0.64048699
101MP0001765_abnormal_ion_homeostasis0.62910092
102MP0001905_abnormal_dopamine_level0.61942181
103MP0002693_abnormal_pancreas_physiology0.60808732
104MP0001663_abnormal_digestive_system0.60375077
105MP0002168_other_aberrant_phenotype0.57669538
106MP0003567_abnormal_fetal_cardiomyocyte0.57296491
107MP0002136_abnormal_kidney_physiology0.56197753
108MP0000613_abnormal_salivary_gland0.55239726
109MP0001542_abnormal_bone_strength0.55204959
110MP0005076_abnormal_cell_differentiation0.54062743
111MP0006036_abnormal_mitochondrial_physio0.54054968
112MP0008770_decreased_survivor_rate0.53724302
113MP0010094_abnormal_chromosome_stability0.53170218
114MP0003075_altered_response_to0.52702038
115MP0001727_abnormal_embryo_implantation0.52581961
116MP0002086_abnormal_extraembryonic_tissu0.52008898
117MP0005636_abnormal_mineral_homeostasis0.51447180
118MP0000371_diluted_coat_color0.51214000
119MP0009764_decreased_sensitivity_to0.50193723
120MP0005645_abnormal_hypothalamus_physiol0.48816290
121MP0003045_fibrosis0.48345653
122MP0000477_abnormal_intestine_morphology0.47719211
123MP0005075_abnormal_melanosome_morpholog0.46901971
124MP0000249_abnormal_blood_vessel0.45369400
125MP0004883_abnormal_blood_vessel0.45262520
126MP0005408_hypopigmentation0.45051412
127MP0009765_abnormal_xenobiotic_induced0.44389030
128MP0004381_abnormal_hair_follicle0.44388046
129MP0000598_abnormal_liver_morphology0.44312060
130MP0004924_abnormal_behavior0.44267907
131MP0005386_behavior/neurological_phenoty0.44267907
132MP0005023_abnormal_wound_healing0.44122556
133MP0008872_abnormal_physiological_respon0.44085108
134MP0005389_reproductive_system_phenotype0.43835852
135MP0001730_embryonic_growth_arrest0.41824288
136MP0002083_premature_death0.40667010
137MP0001881_abnormal_mammary_gland0.37829367

Predicted human phenotypes

RankGene SetZ-score
1Hemiplegia (HP:0002301)8.30361084
2Hypoproteinemia (HP:0003075)7.10768816
3Tetraplegia (HP:0002445)6.14565226
4Encephalitis (HP:0002383)6.12508731
5T lymphocytopenia (HP:0005403)5.81615792
6Abnormality of T cell number (HP:0011839)5.60371259
7Abnormality of the common coagulation pathway (HP:0010990)5.56455885
8Increased serum ferritin (HP:0003281)5.44600183
9Aplastic anemia (HP:0001915)5.33354492
10Abnormality of macrophages (HP:0004311)5.30384809
11Joint swelling (HP:0001386)5.14281930
12Increased CSF protein (HP:0002922)4.93718551
13Optic neuritis (HP:0100653)4.90622704
14Retrobulbar optic neuritis (HP:0100654)4.90622704
15Nasal polyposis (HP:0100582)4.85906969
16Abnormality of iron homeostasis (HP:0011031)4.79771054
17Myositis (HP:0100614)4.79132085
18Chronic mucocutaneous candidiasis (HP:0002728)4.44079660
19Recurrent cutaneous fungal infections (HP:0011370)4.44079660
20Hypoalbuminemia (HP:0003073)4.39657546
21Abnormal albumin level (HP:0012116)4.39657546
22Orchitis (HP:0100796)4.24850145
23Increased density of long bones (HP:0006392)4.19584319
24Abnormality of transition element cation homeostasis (HP:0011030)4.09179236
25Meningitis (HP:0001287)3.96121887
26Abnormality of the nasal mucosa (HP:0000433)3.91842839
27Abnormal platelet volume (HP:0011876)3.70464702
28Abnormality of T cells (HP:0002843)3.63831276
29Keratoconjunctivitis sicca (HP:0001097)3.58703559
30Hyponatremia (HP:0002902)3.57485640
31Stomatitis (HP:0010280)3.55323553
32Increased mean platelet volume (HP:0011877)3.40351467
33Bilateral sensorineural hearing impairment (HP:0008619)3.24064818
34Keratoconjunctivitis (HP:0001096)3.19540029
35Hypertriglyceridemia (HP:0002155)3.16634798
363-Methylglutaconic aciduria (HP:0003535)3.10393015
37IgM deficiency (HP:0002850)3.08379067
38Abnormality of oral frenula (HP:0000190)3.05984482
39Prolonged bleeding time (HP:0003010)3.04574508
40Gingival bleeding (HP:0000225)3.04089754
41Lymphoma (HP:0002665)3.01556010
42Recurrent viral infections (HP:0004429)3.00038697
43Abnormality of sodium homeostasis (HP:0010931)2.98492098
44Abnormality of intracranial pressure (HP:0012640)2.98471828
45Increased intracranial pressure (HP:0002516)2.98471828
46Abnormality of binocular vision (HP:0011514)2.96360810
47Diplopia (HP:0000651)2.96360810
48Thyroiditis (HP:0100646)2.96340150
49Arterial thrombosis (HP:0004420)2.95552896
50Recurrent bronchitis (HP:0002837)2.95126076
51Menorrhagia (HP:0000132)2.84025922
52Chronic otitis media (HP:0000389)2.80048051
53Petechiae (HP:0000967)2.77853090
54Pulmonary embolism (HP:0002204)2.77199941
55Hypoplasia of the thymus (HP:0000778)2.75181878
56IgA deficiency (HP:0002720)2.72063143
57Abnormality of the prostate (HP:0008775)2.68418849
58Eczematoid dermatitis (HP:0000976)2.66302043
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.66181067
60Oral leukoplakia (HP:0002745)2.59626309
61Spontaneous hematomas (HP:0007420)2.57446099
62Recurrent skin infections (HP:0001581)2.56327854
63Autoimmune thrombocytopenia (HP:0001973)2.56284660
64Agammaglobulinemia (HP:0004432)2.55505201
65Vasculitis (HP:0002633)2.55054124
66Acute necrotizing encephalopathy (HP:0006965)2.53954553
67Elevated erythrocyte sedimentation rate (HP:0003565)2.51573106
68Increased intramyocellular lipid droplets (HP:0012240)2.49532087
69Recurrent fungal infections (HP:0002841)2.48745474
70Abnormal platelet function (HP:0011869)2.47442392
71Impaired platelet aggregation (HP:0003540)2.47442392
72Increased hepatocellular lipid droplets (HP:0006565)2.46185470
73Hyperbilirubinemia (HP:0002904)2.45233968
74Anorexia (HP:0002039)2.44873892
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44638230
76Ureteral obstruction (HP:0006000)2.44418889
77Epistaxis (HP:0000421)2.42267049
78Pulmonary infiltrates (HP:0002113)2.42158088
79Abnormality of eosinophils (HP:0001879)2.41753481
80Abnormality of the fingertips (HP:0001211)2.40867881
81Acute hepatic failure (HP:0006554)2.40072367
82Eosinophilia (HP:0001880)2.33775305
83Severe combined immunodeficiency (HP:0004430)2.33696882
84Purpura (HP:0000979)2.32738232
85Mitochondrial inheritance (HP:0001427)2.32177592
86Recurrent abscess formation (HP:0002722)2.28393015
87Abnormal mitochondria in muscle tissue (HP:0008316)2.26033858
88Lipid accumulation in hepatocytes (HP:0006561)2.20496240
89Leukocytosis (HP:0001974)2.19700340
90Acute encephalopathy (HP:0006846)2.18685031
91Carpal bone hypoplasia (HP:0001498)2.18510434
92Gangrene (HP:0100758)2.17574236
93Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17083245
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17083245
95Pancytopenia (HP:0001876)2.16949817
96Molar tooth sign on MRI (HP:0002419)2.13285356
97Abnormality of midbrain morphology (HP:0002418)2.13285356
98Trigonocephaly (HP:0000243)2.12991076
99Renal cortical cysts (HP:0000803)2.11855375
100Combined immunodeficiency (HP:0005387)2.10723045
101Renal Fanconi syndrome (HP:0001994)2.08556440
102Abnormality of the renal cortex (HP:0011035)2.07707776
103Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07058909
104Leukopenia (HP:0001882)2.05324036
105Hemoptysis (HP:0002105)2.04227498
106Inflammation of the large intestine (HP:0002037)2.04152213
107Increased muscle lipid content (HP:0009058)2.03424033
108Periodontitis (HP:0000704)2.03176328
109Abnormal delayed hypersensitivity skin test (HP:0002963)2.02807584
110Gastrointestinal inflammation (HP:0004386)2.01916260
111Gastrointestinal infarctions (HP:0005244)2.01567350
112Progressive macrocephaly (HP:0004481)2.00843013
113Bronchitis (HP:0012387)1.97922948
114Increased CSF lactate (HP:0002490)1.97887411
115Duplicated collecting system (HP:0000081)1.97831613
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95469488
117Abnormality of T cell physiology (HP:0011840)1.94729878
118Chest pain (HP:0100749)1.93641378
119Mediastinal lymphadenopathy (HP:0100721)1.93115856
120Arthralgia (HP:0002829)1.92717856
121Thrombocytosis (HP:0001894)1.90219233
122Pulmonary fibrosis (HP:0002206)1.89486581
123IgG deficiency (HP:0004315)1.87227099
124Increased IgM level (HP:0003496)1.87225677
125Chronic obstructive pulmonary disease (HP:0006510)1.86854169
126Obstructive lung disease (HP:0006536)1.86854169
127Anhidrosis (HP:0000970)1.85715502
128Granulocytopenia (HP:0001913)1.85351041
129Abnormality of the renal collecting system (HP:0004742)1.85016552
130Cerebral edema (HP:0002181)1.83243477
131Skin rash (HP:0000988)1.79869908
132Panhypogammaglobulinemia (HP:0003139)1.78064617
133Deviation of the thumb (HP:0009603)1.77662322
134Increased IgE level (HP:0003212)1.74566404
135Hypobetalipoproteinemia (HP:0003563)1.73872669
136Ureteral stenosis (HP:0000071)1.72810612
137Keratitis (HP:0000491)1.71575385
138Papilledema (HP:0001085)1.70354767
139Abnormality of the metopic suture (HP:0005556)1.70127958
140Lymphopenia (HP:0001888)1.68795504
141Chronic diarrhea (HP:0002028)1.68346173
142Autoimmune hemolytic anemia (HP:0001890)1.64983181
143Pustule (HP:0200039)1.64935653
144Abnormality of the pleura (HP:0002103)1.64873585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.23896300
2GRK75.38926959
3JAK13.81668799
4MAP4K13.74491020
5RIPK13.33095488
6ADRBK23.10474057
7BCKDK3.02571655
8ITK2.69370749
9PIK3CA2.61040769
10STK102.58742960
11MAPKAPK32.48311985
12ZAP702.12560384
13TAOK21.93675138
14WNK41.87489699
15MST41.85097718
16MAP3K141.72835105
17PIK3CG1.71756411
18JAK31.68915519
19FES1.68268987
20NUAK11.63864107
21TSSK61.58160090
22LCK1.57248544
23PIM11.56299729
24TESK21.55726414
25MATK1.55390837
26TRIB31.51962220
27MAP3K31.51713136
28NTRK11.50544150
29TESK11.47792261
30CSK1.43095380
31TYK21.40393757
32EPHB11.38101763
33KIT1.37342888
34ALK1.34255660
35IKBKB1.28851708
36BUB11.28397606
37EIF2AK11.23301189
38CDC71.21460660
39NLK1.20679287
40MAP3K101.20190647
41EEF2K1.17023243
42SRPK11.15877069
43CDK41.15480798
44PRKCQ1.14009596
45LRRK21.13591081
46MAP2K31.13285850
47GRK61.12137547
48NME11.10730504
49SYK1.06136434
50PRKCH0.98377069
51TAOK30.98329556
52FGFR40.95295723
53MAP3K120.94404089
54TLK10.94125396
55DAPK10.90133968
56TTN0.88069923
57KDR0.87135892
58CDK120.87022357
59BTK0.85512965
60JAK20.83441093
61EIF2AK30.83190023
62HCK0.81606543
63STK390.80115199
64TBK10.78094107
65CAMKK20.77557923
66DMPK0.75153753
67SIK20.74768805
68FGFR30.73437826
69MAP3K70.71877263
70LYN0.71072981
71ZAK0.70262535
72VRK20.68883189
73BMPR20.68560270
74IGF1R0.66849007
75BLK0.63623490
76CDK60.62702285
77BMX0.58727095
78STK160.57642203
79MAP3K50.57504884
80EPHA30.57312343
81CLK10.54210782
82IRAK30.53640479
83INSR0.52148454
84TNK20.52065504
85MAP3K10.51241284
86MARK30.50926144
87MAP4K20.49019338
88TEC0.47426542
89FGFR10.45127047
90CHUK0.44201381
91MAP3K80.44149724
92CSNK1A1L0.42784231
93WNK10.41136349
94GRK10.40419108
95ATR0.39682824
96VRK10.38719897
97IRAK10.37749782
98PINK10.37442887
99IKBKE0.37255651
100IRAK40.36371141
101EIF2AK20.36154999
102FYN0.35458029
103CSNK1G20.34253323
104STK240.33314549
105CAMK2A0.32971979
106PTK60.32694449
107RPS6KA50.32434964
108CSF1R0.32269645
109NEK10.31024843
110PDK10.30662865
111TGFBR20.30596804
112GSK3A0.30562041
113CSNK1G30.30255496
114ACVR1B0.29728204
115CAMK2D0.29323645
116NEK20.29316098
117DAPK20.29110036
118TRPM70.28782033
119RPS6KA10.27953010
120PKN20.27911248
121MAP2K70.27741049
122TYRO30.27620654
123PLK30.27193757
124TIE10.27130671
125PIM20.25294644
126PTK20.25153162
127MAPKAPK20.25061116
128PRKCA0.24527557
129MYLK0.24389615
130TAOK10.24047598
131SCYL20.23899104
132OXSR10.23846119
133CCNB10.23214537
134PDGFRB0.22803910
135GRK50.22661656
136RAF10.21711258
137MAP2K60.21361389
138MAP3K110.20977705
139PLK40.20579574
140RPS6KB10.20522621
141MAPK40.20480946
142HIPK20.19890468
143SRC0.19658277
144PRKCB0.17606482
145PRKG20.17108524
146RPS6KA40.16683187
147CHEK10.16363985
148CSNK1A10.14670906

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053327.95421874
2* Allograft rejection_Homo sapiens_hsa053305.82932630
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.52492941
4* Type I diabetes mellitus_Homo sapiens_hsa049404.01731289
5* Autoimmune thyroid disease_Homo sapiens_hsa053203.82964788
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.29101477
7Viral myocarditis_Homo sapiens_hsa054163.04237924
8Antigen processing and presentation_Homo sapiens_hsa046122.97553274
9T cell receptor signaling pathway_Homo sapiens_hsa046602.23809104
10Measles_Homo sapiens_hsa051621.93128032
11Primary immunodeficiency_Homo sapiens_hsa053401.92365959
12Protein export_Homo sapiens_hsa030601.84091923
13RNA polymerase_Homo sapiens_hsa030201.79468541
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.72545253
15Caffeine metabolism_Homo sapiens_hsa002321.60623772
16Asthma_Homo sapiens_hsa053101.46524617
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.42352181
18Leishmaniasis_Homo sapiens_hsa051401.34877226
19Toxoplasmosis_Homo sapiens_hsa051451.33247134
20Oxidative phosphorylation_Homo sapiens_hsa001901.32802168
21* Apoptosis_Homo sapiens_hsa042101.31867409
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31461963
23Malaria_Homo sapiens_hsa051441.29925991
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.19563488
25Parkinsons disease_Homo sapiens_hsa050121.19055354
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.15491049
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14704331
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13430430
29Osteoclast differentiation_Homo sapiens_hsa043801.10236121
30B cell receptor signaling pathway_Homo sapiens_hsa046621.08704522
31Sulfur metabolism_Homo sapiens_hsa009201.08535045
32Hematopoietic cell lineage_Homo sapiens_hsa046401.08304596
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06798915
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99876741
35Leukocyte transendothelial migration_Homo sapiens_hsa046700.96673569
36DNA replication_Homo sapiens_hsa030300.93970149
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86355666
38Staphylococcus aureus infection_Homo sapiens_hsa051500.84162659
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82780310
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80270328
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79810528
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79043504
43Chemokine signaling pathway_Homo sapiens_hsa040620.78956813
44Hepatitis B_Homo sapiens_hsa051610.75401195
45Platelet activation_Homo sapiens_hsa046110.74896377
46HTLV-I infection_Homo sapiens_hsa051660.74389172
47Linoleic acid metabolism_Homo sapiens_hsa005910.74174197
48Nitrogen metabolism_Homo sapiens_hsa009100.71254082
49Shigellosis_Homo sapiens_hsa051310.70316739
50TNF signaling pathway_Homo sapiens_hsa046680.69618963
51Renin-angiotensin system_Homo sapiens_hsa046140.67900169
52Viral carcinogenesis_Homo sapiens_hsa052030.67691168
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67065960
54Epstein-Barr virus infection_Homo sapiens_hsa051690.65301960
55Pertussis_Homo sapiens_hsa051330.65054300
56Acute myeloid leukemia_Homo sapiens_hsa052210.64648121
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64284072
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63175531
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63009059
60One carbon pool by folate_Homo sapiens_hsa006700.60858155
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60690879
62Mismatch repair_Homo sapiens_hsa034300.60227886
63Herpes simplex infection_Homo sapiens_hsa051680.59254867
64Proteasome_Homo sapiens_hsa030500.57162718
65Tuberculosis_Homo sapiens_hsa051520.56975133
66Pyrimidine metabolism_Homo sapiens_hsa002400.54944448
67Alzheimers disease_Homo sapiens_hsa050100.54783071
68Endocytosis_Homo sapiens_hsa041440.54655154
69Regulation of autophagy_Homo sapiens_hsa041400.53283111
70Phototransduction_Homo sapiens_hsa047440.53170078
71Salmonella infection_Homo sapiens_hsa051320.51963213
72Influenza A_Homo sapiens_hsa051640.51886733
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50988311
74VEGF signaling pathway_Homo sapiens_hsa043700.50224063
75Amoebiasis_Homo sapiens_hsa051460.48077188
76Legionellosis_Homo sapiens_hsa051340.47604700
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45006553
78Chronic myeloid leukemia_Homo sapiens_hsa052200.44993511
79Pancreatic cancer_Homo sapiens_hsa052120.43639934
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43221386
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42152889
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41214617
83Colorectal cancer_Homo sapiens_hsa052100.41181405
84Purine metabolism_Homo sapiens_hsa002300.38363580
85Huntingtons disease_Homo sapiens_hsa050160.37942955
86Steroid biosynthesis_Homo sapiens_hsa001000.37832895
87Prion diseases_Homo sapiens_hsa050200.35005609
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34979146
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34785721
90p53 signaling pathway_Homo sapiens_hsa041150.34577279
91Cardiac muscle contraction_Homo sapiens_hsa042600.32162644
92RNA degradation_Homo sapiens_hsa030180.29312597
93Biosynthesis of amino acids_Homo sapiens_hsa012300.29129774
94RNA transport_Homo sapiens_hsa030130.29107190
95Small cell lung cancer_Homo sapiens_hsa052220.28699137
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28128830
97Spliceosome_Homo sapiens_hsa030400.28035479
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27986564
99Peroxisome_Homo sapiens_hsa041460.27810063
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27688695
101Hepatitis C_Homo sapiens_hsa051600.27453530
102Renal cell carcinoma_Homo sapiens_hsa052110.27249154
103Pentose phosphate pathway_Homo sapiens_hsa000300.26166019
104* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25519516
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.25405271
106Chemical carcinogenesis_Homo sapiens_hsa052040.24391107
107Non-small cell lung cancer_Homo sapiens_hsa052230.24095494
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23978284
109MicroRNAs in cancer_Homo sapiens_hsa052060.22919130
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.21478863
111African trypanosomiasis_Homo sapiens_hsa051430.20995202
112Base excision repair_Homo sapiens_hsa034100.19956379
113Basal transcription factors_Homo sapiens_hsa030220.19253722
114Homologous recombination_Homo sapiens_hsa034400.18032356
115Systemic lupus erythematosus_Homo sapiens_hsa053220.17926230
116Focal adhesion_Homo sapiens_hsa045100.17318331
117Rap1 signaling pathway_Homo sapiens_hsa040150.15735563
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.14057312
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12933453
120Notch signaling pathway_Homo sapiens_hsa043300.12627694
121Propanoate metabolism_Homo sapiens_hsa006400.12101106
122Prolactin signaling pathway_Homo sapiens_hsa049170.11855298
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11119074
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11047063
125Rheumatoid arthritis_Homo sapiens_hsa053230.10439849
126Ether lipid metabolism_Homo sapiens_hsa005650.10373745
127MAPK signaling pathway_Homo sapiens_hsa040100.09883522
128Collecting duct acid secretion_Homo sapiens_hsa049660.08705026
129HIF-1 signaling pathway_Homo sapiens_hsa040660.08598172
130Fatty acid elongation_Homo sapiens_hsa000620.07898960
131mRNA surveillance pathway_Homo sapiens_hsa030150.07679657
132Lysine degradation_Homo sapiens_hsa003100.06833643
133Dilated cardiomyopathy_Homo sapiens_hsa054140.06229238
134N-Glycan biosynthesis_Homo sapiens_hsa005100.06116421
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.05874009
136Cell cycle_Homo sapiens_hsa041100.05674723
137Long-term potentiation_Homo sapiens_hsa047200.03733785
138Nucleotide excision repair_Homo sapiens_hsa034200.02065845

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