GZMM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.68313397
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.26898364
3antigen processing and presentation of endogenous antigen (GO:0019883)6.78774882
4detection of bacterium (GO:0016045)6.73986558
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.67864713
6regulation of dendritic cell antigen processing and presentation (GO:0002604)6.24855236
7DNA strand renaturation (GO:0000733)6.18961650
8regulation of double-strand break repair via homologous recombination (GO:0010569)5.87962093
9interferon-gamma production (GO:0032609)5.85674043
10detection of other organism (GO:0098543)5.84848722
11cellular response to interleukin-15 (GO:0071350)5.83508980
12response to interleukin-15 (GO:0070672)5.36321669
13negative regulation of T cell mediated immunity (GO:0002710)5.35115867
14negative T cell selection (GO:0043383)5.12941595
15regulation of histone H3-K27 methylation (GO:0061085)5.05375795
16negative thymic T cell selection (GO:0045060)4.90929913
17positive regulation of gamma-delta T cell activation (GO:0046645)4.82901431
18positive regulation of antigen processing and presentation (GO:0002579)4.76039368
19T cell migration (GO:0072678)4.63600913
20positive regulation of granulocyte differentiation (GO:0030854)4.47364343
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.41359317
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.41359317
23modulation by symbiont of host immune response (GO:0052553)4.41359317
24positive regulation by symbiont of host defense response (GO:0052509)4.41359317
25modulation by symbiont of host defense response (GO:0052031)4.41359317
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.41359317
27neutrophil activation involved in immune response (GO:0002283)4.39390773
28regulation of T cell tolerance induction (GO:0002664)4.38423931
29negative regulation of phagocytosis (GO:0050765)4.30100479
30tolerance induction (GO:0002507)4.27826655
31behavioral response to nicotine (GO:0035095)4.24872355
32mitotic sister chromatid cohesion (GO:0007064)4.15678138
33protein localization to kinetochore (GO:0034501)4.15042157
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.11585138
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.08086283
36regulation of natural killer cell mediated immunity (GO:0002715)4.08086283
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.06361881
38positive regulation of natural killer cell mediated immunity (GO:0002717)4.06361881
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.93342042
40regulation of leukocyte mediated cytotoxicity (GO:0001910)3.89315889
41regulation of alpha-beta T cell proliferation (GO:0046640)3.86573556
42regulation of gamma-delta T cell differentiation (GO:0045586)3.85104016
43regulation of tolerance induction (GO:0002643)3.82337034
44type I interferon signaling pathway (GO:0060337)3.76482503
45cellular response to type I interferon (GO:0071357)3.76482503
46regulation of isotype switching to IgG isotypes (GO:0048302)3.74635145
47regulation of B cell differentiation (GO:0045577)3.74275299
48antigen processing and presentation via MHC class Ib (GO:0002475)3.73647558
49response to type I interferon (GO:0034340)3.73531416
50thymic T cell selection (GO:0045061)3.73343619
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.71204725
52regulation of response to tumor cell (GO:0002834)3.68710343
53positive regulation of response to tumor cell (GO:0002836)3.68710343
54positive regulation of immune response to tumor cell (GO:0002839)3.68710343
55regulation of immune response to tumor cell (GO:0002837)3.68710343
56B cell receptor signaling pathway (GO:0050853)3.67527495
57respiratory burst (GO:0045730)3.67183969
58regulation of rhodopsin mediated signaling pathway (GO:0022400)3.67150838
59regulation of antigen processing and presentation (GO:0002577)3.66092503
60neutrophil activation (GO:0042119)3.65637007
61regulation of RNA export from nucleus (GO:0046831)3.62842494
62regulation of double-strand break repair (GO:2000779)3.61571899
63regulation of regulatory T cell differentiation (GO:0045589)3.61231895
64macrophage activation involved in immune response (GO:0002281)3.59968324
65L-amino acid import (GO:0043092)3.57386761
66megakaryocyte development (GO:0035855)3.56655187
67cellular extravasation (GO:0045123)3.54136771
68immunoglobulin mediated immune response (GO:0016064)3.52592068
69protein localization to chromosome, centromeric region (GO:0071459)3.52089590
70sphingomyelin metabolic process (GO:0006684)3.51671142
71regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.50238296
72germ cell migration (GO:0008354)3.49802632
73regulation of gamma-delta T cell activation (GO:0046643)3.48501080
74positive regulation of B cell differentiation (GO:0045579)3.45372826
75granulocyte differentiation (GO:0030851)3.44849433
76regulation of cell killing (GO:0031341)3.41175802
77rhodopsin mediated signaling pathway (GO:0016056)3.39190965
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37823546
79antigen receptor-mediated signaling pathway (GO:0050851)3.37319962
80V(D)J recombination (GO:0033151)3.37271035
81positive regulation of tolerance induction (GO:0002645)3.37165248
82positive thymic T cell selection (GO:0045059)3.37043175
83embryonic process involved in female pregnancy (GO:0060136)3.36351315
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35844623
85positive T cell selection (GO:0043368)3.35412779
86regulation of response to interferon-gamma (GO:0060330)3.34377077
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33710457
88positive regulation of DNA repair (GO:0045739)3.29957397
89leukocyte migration involved in inflammatory response (GO:0002523)3.27592583
90negative regulation of innate immune response (GO:0045824)3.27577313
91granulocyte activation (GO:0036230)3.27097607
92regulation of B cell receptor signaling pathway (GO:0050855)3.22432779
93T cell homeostasis (GO:0043029)3.21145280
94positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20994811
95regulation of T cell mediated cytotoxicity (GO:0001914)3.16414025
96myeloid cell activation involved in immune response (GO:0002275)3.14615479
97T cell selection (GO:0045058)3.14522411
98mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13881112
99mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13881112
100virion assembly (GO:0019068)3.12173017
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10704727
102leukocyte degranulation (GO:0043299)3.09528534
103regulation of DNA recombination (GO:0000018)3.09325613
104regulation of interferon-beta biosynthetic process (GO:0045357)3.08804524
105kinetochore organization (GO:0051383)3.07286936
106B cell proliferation (GO:0042100)3.06468260
107positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05553566
108T cell receptor signaling pathway (GO:0050852)3.04761052
109viral protein processing (GO:0019082)3.03876376
110kinetochore assembly (GO:0051382)3.02355341
111regulation of T cell mediated immunity (GO:0002709)2.99686057
112negative regulation of alpha-beta T cell activation (GO:0046636)2.99610117
113regulation of interleukin-2 biosynthetic process (GO:0045076)2.99137283
114negative regulation of erythrocyte differentiation (GO:0045647)2.97302274
115interferon-gamma-mediated signaling pathway (GO:0060333)2.95747144
116positive regulation of immunoglobulin mediated immune response (GO:0002891)2.95527194
117positive regulation of B cell mediated immunity (GO:0002714)2.95527194
118negative regulation of interleukin-12 production (GO:0032695)2.94396701
119response to peptidoglycan (GO:0032494)2.94180786
120B cell mediated immunity (GO:0019724)2.93886668
121signal complex assembly (GO:0007172)2.92780218
122negative regulation of leukocyte mediated immunity (GO:0002704)2.92582232
123lymphocyte migration (GO:0072676)2.90618285
124regulation of mast cell degranulation (GO:0043304)2.90488774
125dendritic cell chemotaxis (GO:0002407)2.90167251
126lymphocyte homeostasis (GO:0002260)2.88258014
127regulation of defense response to virus by virus (GO:0050690)2.87849130
128positive regulation of T cell differentiation in thymus (GO:0033089)2.87354665
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86692671
130response to host immune response (GO:0052572)2.86692671
131response to muramyl dipeptide (GO:0032495)2.85652017
132termination of RNA polymerase I transcription (GO:0006363)2.84758622
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83655997
134cytokine biosynthetic process (GO:0042089)2.81222857
135detection of external biotic stimulus (GO:0098581)2.80030864
136microtubule severing (GO:0051013)2.79046412
137T cell differentiation involved in immune response (GO:0002292)2.78627851
138alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78627851
139alpha-beta T cell activation involved in immune response (GO:0002287)2.78627851
140smooth muscle tissue development (GO:0048745)2.77787931
141activated T cell proliferation (GO:0050798)2.77374457
142DNA replication checkpoint (GO:0000076)2.76703237
143positive regulation of cell killing (GO:0031343)2.75852584
144leukocyte aggregation (GO:0070486)2.75520133
145protein heterotetramerization (GO:0051290)2.72211554
146monocyte differentiation (GO:0030224)2.72024723
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71423965
148T cell differentiation (GO:0030217)2.70399804
149replication fork processing (GO:0031297)2.68982218
150positive regulation of vascular permeability (GO:0043117)2.67375169
151T-helper cell differentiation (GO:0042093)2.64515221
152CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.64515221
153sensory perception of taste (GO:0050909)2.64179540
154negative regulation of gene silencing (GO:0060969)2.63470659
155retinal cone cell development (GO:0046549)2.63293022
156negative regulation of chemokine production (GO:0032682)2.62004149
157mast cell activation (GO:0045576)2.60918372
158detection of biotic stimulus (GO:0009595)2.58109262
159negative regulation of cell killing (GO:0031342)12.5254248
160negative regulation of leukocyte mediated cytotoxicity (GO:0001911)12.5254248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02470373
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.71834232
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.52570387
4NOTCH1_21737748_ChIP-Seq_TLL_Human4.15071509
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85077570
6RUNX_20019798_ChIP-Seq_JUKART_Human3.79742579
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.57921643
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44238080
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.42187195
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.36042087
11MYC_22102868_ChIP-Seq_BL_Human2.86169444
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63370930
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.44952314
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.44567891
15MYB_26560356_Chip-Seq_TH2_Human2.42995699
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.39776819
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32477170
18SPI1_23127762_ChIP-Seq_K562_Human2.17640124
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.16244640
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14658331
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09894201
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04218540
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98260635
24MYB_26560356_Chip-Seq_TH1_Human1.97437888
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97017530
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95548717
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94806153
28POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94488417
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93664079
30UTX_26944678_Chip-Seq_JUKART_Human1.93286670
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.85657432
32MAF_26560356_Chip-Seq_TH1_Human1.74371627
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72745625
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68842392
35* MAF_26560356_Chip-Seq_TH2_Human1.64440777
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63990092
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63956314
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60394338
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58837730
40FOXP3_21729870_ChIP-Seq_TREG_Human1.58280255
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57728111
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57155158
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55010564
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.54504282
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53459810
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.53438509
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.49249096
48SPI1_23547873_ChIP-Seq_NB4_Human1.47755526
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.46135812
50LXR_22292898_ChIP-Seq_THP-1_Human1.45239063
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43725741
52VDR_24763502_ChIP-Seq_THP-1_Human1.43613847
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41998657
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41220567
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.39346061
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38253718
57GATA3_27048872_Chip-Seq_THYMUS_Human1.38226947
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38144779
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.37693137
60SCL_19346495_ChIP-Seq_HPC-7_Human1.37532970
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37241443
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37150773
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.36586103
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35377530
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34241822
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34241822
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32624764
68GATA3_26560356_Chip-Seq_TH2_Human1.32146362
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30945859
70* BCL6_27268052_Chip-Seq_Bcells_Human1.29034922
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28062823
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28031901
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27840249
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25126557
75VDR_21846776_ChIP-Seq_THP-1_Human1.23560938
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22213582
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.21527066
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21442417
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.20494056
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20342484
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18918215
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18881919
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18638186
84BCOR_27268052_Chip-Seq_Bcells_Human1.18309517
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16105471
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15607348
87* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15247834
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14987489
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14983870
90* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14947678
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14453095
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11822202
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11282873
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09750856
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09417319
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09252435
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08528434
98VDR_23849224_ChIP-Seq_CD4+_Human1.08395167
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08255063
100IRF1_19129219_ChIP-ChIP_H3396_Human1.05532177
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04609369
102PU_27001747_Chip-Seq_BMDM_Mouse1.03216879
103TCF7_22412390_ChIP-Seq_EML_Mouse1.02794760
104VDR_24787735_ChIP-Seq_THP-1_Human1.01969225
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01215352
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.00668065
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00499199
108KDM2B_26808549_Chip-Seq_DND41_Human1.00429048
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97957789
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97957789
111P68_20966046_ChIP-Seq_HELA_Human0.97772346
112MYC_18555785_ChIP-Seq_MESCs_Mouse0.97035320
113RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97010300
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.95540015
115MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95234635
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94201945
117CIITA_25753668_ChIP-Seq_RAJI_Human0.93692018
118RXR_22108803_ChIP-Seq_LS180_Human0.93179593
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91421962
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91314409
121NCOR1_26117541_ChIP-Seq_K562_Human0.90577317
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89946372
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88654910
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88196652
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87747030
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86165336
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86119331
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84553259
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84453492
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84452125
131MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83844185
132MYC_18940864_ChIP-ChIP_HL60_Human0.83660618
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83181856
134FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82092193
135SPI1_20517297_ChIP-Seq_HL60_Human0.81418737
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78098839
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77064246
138HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.76676718
139CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.76388452
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73241195
141TBX3_20139965_ChIP-Seq_ESCs_Mouse0.71607095
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71531482
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71352454
144GATA1_19941826_ChIP-Seq_K562_Human0.71145548
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.71045744
146CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.69691350
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.68936648
148SOX2_21211035_ChIP-Seq_LN229_Human0.68264612
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67644627
150SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.65182716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.38570880
2MP0003724_increased_susceptibility_to4.29697379
3MP0003763_abnormal_thymus_physiology4.01425329
4MP0009278_abnormal_bone_marrow3.77774052
5MP0003950_abnormal_plasma_membrane3.50100364
6MP0005671_abnormal_response_to3.34780509
7MP0001873_stomach_inflammation3.26502339
8MP0000685_abnormal_immune_system2.85551834
9MP0004147_increased_porphyrin_level2.80769124
10MP0008007_abnormal_cellular_replicative2.80019102
11MP0003303_peritoneal_inflammation2.77692077
12MP0009333_abnormal_splenocyte_physiolog2.64034900
13MP0008057_abnormal_DNA_replication2.51102595
14MP0003300_gastrointestinal_ulcer2.49588743
15MP0003111_abnormal_nucleus_morphology2.48159737
16MP0001188_hyperpigmentation2.46976615
17MP0009379_abnormal_foot_pigmentation2.42831917
18MP0001529_abnormal_vocalization2.37208869
19MP0005423_abnormal_somatic_nervous2.34020119
20MP0004381_abnormal_hair_follicle2.29954892
21MP0003693_abnormal_embryo_hatching2.27252166
22MP0001533_abnormal_skeleton_physiology2.08133672
23MP0001986_abnormal_taste_sensitivity2.07708948
24MP0002148_abnormal_hypersensitivity_rea2.04546574
25MP0003828_pulmonary_edema2.01526887
26MP0005397_hematopoietic_system_phenotyp1.93837270
27MP0001545_abnormal_hematopoietic_system1.93837270
28MP0004947_skin_inflammation1.90565519
29MP0005464_abnormal_platelet_physiology1.88668315
30MP0005075_abnormal_melanosome_morpholog1.86349899
31MP0002009_preneoplasia1.85760760
32MP0003077_abnormal_cell_cycle1.83787871
33MP0002132_abnormal_respiratory_system1.75545467
34MP0010352_gastrointestinal_tract_polyps1.74989534
35MP0000858_altered_metastatic_potential1.72442895
36MP0004808_abnormal_hematopoietic_stem1.72109961
37MP0005330_cardiomyopathy1.67157165
38MP0005551_abnormal_eye_electrophysiolog1.66977517
39MP0008995_early_reproductive_senescence1.66576169
40MP0001790_abnormal_immune_system1.64588791
41MP0005387_immune_system_phenotype1.64588791
42MP0006292_abnormal_olfactory_placode1.63362470
43MP0005451_abnormal_body_composition1.62405264
44MP0010094_abnormal_chromosome_stability1.59930051
45MP0002398_abnormal_bone_marrow1.58614374
46MP0000703_abnormal_thymus_morphology1.57862226
47MP0002876_abnormal_thyroid_physiology1.55182027
48MP0005394_taste/olfaction_phenotype1.54948251
49MP0005499_abnormal_olfactory_system1.54948251
50MP0000465_gastrointestinal_hemorrhage1.54472091
51MP0008961_abnormal_basal_metabolism1.51789440
52MP0005310_abnormal_salivary_gland1.51757168
53MP0003890_abnormal_embryonic-extraembry1.51153161
54MP0003191_abnormal_cellular_cholesterol1.50094262
55MP0001819_abnormal_immune_cell1.49638731
56MP0001542_abnormal_bone_strength1.49214919
57MP0002420_abnormal_adaptive_immunity1.48759862
58MP0003172_abnormal_lysosome_physiology1.46083333
59MP0000751_myopathy1.45955048
60MP0008469_abnormal_protein_level1.44683289
61MP0008260_abnormal_autophagy1.37012250
62MP0005253_abnormal_eye_physiology1.36026647
63MP0000689_abnormal_spleen_morphology1.35883354
64MP0002722_abnormal_immune_system1.34318819
65MP0002006_tumorigenesis1.34019010
66MP0002277_abnormal_respiratory_mucosa1.32317158
67MP0005171_absent_coat_pigmentation1.32311934
68MP0000749_muscle_degeneration1.32184327
69MP0002452_abnormal_antigen_presenting1.32099026
70MP0003786_premature_aging1.30949117
71MP0003941_abnormal_skin_development1.29400681
72MP0004510_myositis1.28739890
73MP0002166_altered_tumor_susceptibility1.28217242
74MP0005409_darkened_coat_color1.26131010
75MP0000716_abnormal_immune_system1.25888811
76MP0001800_abnormal_humoral_immune1.25857281
77MP0002405_respiratory_system_inflammati1.23618798
78MP0004957_abnormal_blastocyst_morpholog1.15614093
79MP0005084_abnormal_gallbladder_morpholo1.14800866
80MP0003279_aneurysm1.14544372
81MP0008058_abnormal_DNA_repair1.13524212
82MP0006054_spinal_hemorrhage1.11051091
83MP0002429_abnormal_blood_cell1.08238367
84MP0003011_delayed_dark_adaptation1.07878874
85MP0002998_abnormal_bone_remodeling1.07060532
86MP0009764_decreased_sensitivity_to1.06225734
87MP0003690_abnormal_glial_cell1.06159784
88MP0002127_abnormal_cardiovascular_syste1.04131424
89MP0001919_abnormal_reproductive_system1.02505762
90MP0002723_abnormal_immune_serum1.02306311
91MP0003448_altered_tumor_morphology1.01910179
92MP0003091_abnormal_cell_migration1.01852406
93MP0006072_abnormal_retinal_apoptosis1.00982474
94MP0004883_abnormal_blood_vessel0.99763391
95MP0003646_muscle_fatigue0.98021845
96MP0009785_altered_susceptibility_to0.97645321
97MP0003183_abnormal_peptide_metabolism0.96044820
98MP0002933_joint_inflammation0.95697779
99MP0001851_eye_inflammation0.91198446
100MP0003045_fibrosis0.89988440
101MP0001984_abnormal_olfaction0.87897386
102MP0001663_abnormal_digestive_system0.85911000
103MP0000490_abnormal_crypts_of0.85432950
104MP0005000_abnormal_immune_tolerance0.83192870
105* MP0005025_abnormal_response_to0.82165179
106MP0002019_abnormal_tumor_incidence0.81914118
107MP0009763_increased_sensitivity_to0.81720468
108MP0005390_skeleton_phenotype0.81638793
109MP0005646_abnormal_pituitary_gland0.81337582
110MP0005166_decreased_susceptibility_to0.79669615
111MP0010155_abnormal_intestine_physiology0.79576924
112MP0008789_abnormal_olfactory_epithelium0.78655786
113MP0002396_abnormal_hematopoietic_system0.77910146
114MP0004130_abnormal_muscle_cell0.77741223
115MP0001764_abnormal_homeostasis0.77178779
116MP0004087_abnormal_muscle_fiber0.76738272
117MP0002419_abnormal_innate_immunity0.76566345
118MP0002138_abnormal_hepatobiliary_system0.75734685
119MP0001661_extended_life_span0.70598028
120MP0005164_abnormal_response_to0.70361433
121MP0006082_CNS_inflammation0.69938611
122MP0001835_abnormal_antigen_presentation0.69164879
123MP0003943_abnormal_hepatobiliary_system0.68939998
124MP0000372_irregular_coat_pigmentation0.68502099
125MP0003075_altered_response_to0.68067880
126MP0001853_heart_inflammation0.67694485
127MP0003866_abnormal_defecation0.65373586
128MP0005391_vision/eye_phenotype0.64572140
129MP0001845_abnormal_inflammatory_respons0.63360755
130MP0002693_abnormal_pancreas_physiology0.63304473
131MP0005386_behavior/neurological_phenoty0.62277999
132MP0004924_abnormal_behavior0.62277999
133MP0002638_abnormal_pupillary_reflex0.61610479
134MP0003795_abnormal_bone_structure0.61055465
135MP0005389_reproductive_system_phenotype0.61036093
136MP0008874_decreased_physiological_sensi0.60124930
137MP0000604_amyloidosis0.57083264
138MP0009765_abnormal_xenobiotic_induced0.56631073
139MP0001348_abnormal_lacrimal_gland0.52240922
140MP0003878_abnormal_ear_physiology0.50518945
141MP0005377_hearing/vestibular/ear_phenot0.50518945
142MP0000249_abnormal_blood_vessel0.50508619
143MP0005381_digestive/alimentary_phenotyp0.48858158
144MP0005083_abnormal_biliary_tract0.48554508
145MP0000015_abnormal_ear_pigmentation0.47878492
146MP0005058_abnormal_lysosome_morphology0.45203227
147MP0002928_abnormal_bile_duct0.43927093
148MP0008004_abnormal_stomach_pH0.43003408
149MP0009840_abnormal_foam_cell0.41509899
150MP0008873_increased_physiological_sensi0.41081551
151MP0000470_abnormal_stomach_morphology0.40068000
152MP0000343_altered_response_to0.38871238
153MP0004858_abnormal_nervous_system0.38717629

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.21095172
2Abnormality of macrophages (HP:0004311)5.24361489
3Recurrent bacterial skin infections (HP:0005406)5.19300750
4Stomatitis (HP:0010280)5.02734086
5Hypoplasia of the capital femoral epiphysis (HP:0003090)4.98073010
6Retrobulbar optic neuritis (HP:0100654)4.88549785
7Optic neuritis (HP:0100653)4.88549785
8Myositis (HP:0100614)4.74430547
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.66816417
10Recurrent fungal infections (HP:0002841)4.32620336
11Absent epiphyses (HP:0010577)4.20218401
12Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.20218401
13Recurrent gram-negative bacterial infections (HP:0005420)4.16157129
14Keratoconjunctivitis sicca (HP:0001097)4.10246584
15Meningitis (HP:0001287)4.08937880
16Obstructive lung disease (HP:0006536)4.00567218
17Chronic obstructive pulmonary disease (HP:0006510)4.00567218
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.97684088
19T lymphocytopenia (HP:0005403)3.94546146
20Orchitis (HP:0100796)3.90867760
21Panhypogammaglobulinemia (HP:0003139)3.89016179
22Increased IgE level (HP:0003212)3.82375577
23Mediastinal lymphadenopathy (HP:0100721)3.75423374
24Keratoconjunctivitis (HP:0001096)3.66663573
25Abnormality of T cell number (HP:0011839)3.61853073
26Vasculitis (HP:0002633)3.60467088
27Recurrent skin infections (HP:0001581)3.56707564
28Hypochromic anemia (HP:0001931)3.51464823
29Asymmetry of the thorax (HP:0001555)3.50328896
30Hypochromic microcytic anemia (HP:0004840)3.43102374
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38825273
32Congenital stationary night blindness (HP:0007642)3.37376417
33Encephalitis (HP:0002383)3.34700938
34Wrist flexion contracture (HP:0001239)3.33315800
35Prolonged bleeding time (HP:0003010)3.31926808
36Thoracic kyphosis (HP:0002942)3.28381972
37Recurrent cutaneous fungal infections (HP:0011370)3.27306376
38Chronic mucocutaneous candidiasis (HP:0002728)3.27306376
39Fibular aplasia (HP:0002990)3.24697877
40IgM deficiency (HP:0002850)3.17012080
41Abnormal rod and cone electroretinograms (HP:0008323)3.16948263
42Chest pain (HP:0100749)3.16823738
43Type I transferrin isoform profile (HP:0003642)3.16224764
44Severe combined immunodeficiency (HP:0004430)3.16147834
45Increased IgM level (HP:0003496)3.16002022
46Chromsome breakage (HP:0040012)3.13353048
47Granulocytopenia (HP:0001913)3.12729785
48Lymphopenia (HP:0001888)3.12655410
49Inflammation of the large intestine (HP:0002037)3.06319728
50Recurrent viral infections (HP:0004429)3.03624754
51Combined immunodeficiency (HP:0005387)3.03585612
52Abnormality of T cell physiology (HP:0011840)3.02093366
53Gastrointestinal inflammation (HP:0004386)3.01549192
54Urticaria (HP:0001025)3.00199177
5511 pairs of ribs (HP:0000878)2.97835778
56Gingivitis (HP:0000230)2.96763069
57Nonimmune hydrops fetalis (HP:0001790)2.96743227
58Central scotoma (HP:0000603)2.94175927
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.93144843
60Pancreatic islet-cell hyperplasia (HP:0004510)2.92541874
61Broad ribs (HP:0000885)2.89174221
62High pitched voice (HP:0001620)2.88109199
63Elevated erythrocyte sedimentation rate (HP:0003565)2.84893684
64Cellulitis (HP:0100658)2.84660879
65Pigmentary retinal degeneration (HP:0001146)2.78236993
66Dyschromatopsia (HP:0007641)2.72930197
67Eosinophilia (HP:0001880)2.72593744
68Microcytic anemia (HP:0001935)2.72306570
69Hypergammaglobulinemia (HP:0010702)2.69537475
70Thyroiditis (HP:0100646)2.67824434
71Petechiae (HP:0000967)2.65538758
72Episodic fever (HP:0001954)2.63144300
73Recurrent bronchitis (HP:0002837)2.63052152
74Pendular nystagmus (HP:0012043)2.60322230
75Glomerulopathy (HP:0100820)2.58032725
76Abnormality of eosinophils (HP:0001879)2.57892342
77Abnormality of T cells (HP:0002843)2.57432168
78Rough bone trabeculation (HP:0100670)2.57423634
79Epistaxis (HP:0000421)2.57050940
80IgG deficiency (HP:0004315)2.56082928
81Bony spicule pigmentary retinopathy (HP:0007737)2.55240613
82Autoimmune hemolytic anemia (HP:0001890)2.50664460
83Fibular hypoplasia (HP:0003038)2.50315492
84Duplicated collecting system (HP:0000081)2.49805967
85Arthropathy (HP:0003040)2.48263917
86Gingival bleeding (HP:0000225)2.45898329
87Gastrointestinal infarctions (HP:0005244)2.45446544
88Ureteral duplication (HP:0000073)2.42021875
89Limb hypertonia (HP:0002509)2.41864710
90Pulmonary infiltrates (HP:0002113)2.41729370
91Colitis (HP:0002583)2.38581613
92Microretrognathia (HP:0000308)2.38201912
93Testicular atrophy (HP:0000029)2.37169223
94Reduced subcutaneous adipose tissue (HP:0003758)2.36174558
95Verrucae (HP:0200043)2.36158049
96Papilloma (HP:0012740)2.36158049
97Pustule (HP:0200039)2.35242464
98Joint swelling (HP:0001386)2.33522222
99Spontaneous hematomas (HP:0007420)2.33233217
100Abnormality of the epiphysis of the femoral head (HP:0010574)2.31990481
101Slow saccadic eye movements (HP:0000514)2.30703530
102Agammaglobulinemia (HP:0004432)2.30558171
103Sepsis (HP:0100806)2.29526216
104Prostate neoplasm (HP:0100787)2.28843840
105Abnormality of the thoracic spine (HP:0100711)2.27907930
106Vertebral arch anomaly (HP:0008438)2.25190855
107Nasal speech (HP:0001611)2.21548422
108Myotonia (HP:0002486)2.19662549
109Birth length less than 3rd percentile (HP:0003561)2.18854900
110Purpura (HP:0000979)2.17517354
111Abnormality of DNA repair (HP:0003254)2.16899969
112Abnormality of femoral epiphyses (HP:0006499)2.16739431
113Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.16739431
114Anorexia (HP:0002039)2.16497930
115Abnormality of the femoral head (HP:0003368)2.16470119
116Nasal polyposis (HP:0100582)2.15577186
117Abnormality of the pleura (HP:0002103)2.14906367
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14037906
119Abnormal protein N-linked glycosylation (HP:0012347)2.14037906
120Abnormal protein glycosylation (HP:0012346)2.14037906
121Abnormal glycosylation (HP:0012345)2.14037906
122Papilledema (HP:0001085)2.13255674
123Congenital, generalized hypertrichosis (HP:0004540)2.11046457
124Atrial fibrillation (HP:0005110)2.11012986
125Gangrene (HP:0100758)2.09828602
126Osteomyelitis (HP:0002754)2.08172535
127Recurrent abscess formation (HP:0002722)2.07924419
128Flat capital femoral epiphysis (HP:0003370)2.07432001
129Chronic otitis media (HP:0000389)2.06627978
130Lymphoma (HP:0002665)2.06478372
131Long foot (HP:0001833)2.06148063
132Acute hepatic failure (HP:0006554)2.05644236
133Acne (HP:0001061)2.04542850
134Hemoptysis (HP:0002105)2.02830999
135Attenuation of retinal blood vessels (HP:0007843)2.01432080
136Skin ulcer (HP:0200042)2.00688685
137Abnormality of the fingertips (HP:0001211)2.00586715
138Febrile seizures (HP:0002373)2.00481647
139Primary atrial arrhythmia (HP:0001692)2.00040889
140Thyroid-stimulating hormone excess (HP:0002925)1.99930471
141Peritonitis (HP:0002586)1.98806865
142Ileus (HP:0002595)1.98078826
143Abnormality of the prostate (HP:0008775)1.97764590
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97244722
145Ectopic kidney (HP:0000086)1.97008183
146Abnormality of macular pigmentation (HP:0008002)1.96037018
147Gastrointestinal stroma tumor (HP:0100723)1.95718634
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.95255906
149Bifid uvula (HP:0000193)1.94311223
150Arterial thrombosis (HP:0004420)1.94201705
151Supraventricular tachycardia (HP:0004755)1.94060276
152Abnormality of the renal collecting system (HP:0004742)1.93526017
153Hemiplegia (HP:0002301)1.93195404
154Pulmonary embolism (HP:0002204)1.93157324
155Increased serum ferritin (HP:0003281)1.92519460
156Keratitis (HP:0000491)1.91064538
157Autoimmune thrombocytopenia (HP:0001973)1.91056178
158Missing ribs (HP:0000921)1.90096430
159Abnormality of the preputium (HP:0100587)1.89664596
160Leukocytosis (HP:0001974)1.85776843
161Aortic valve stenosis (HP:0001650)1.85218090
162Premature graying of hair (HP:0002216)1.85123180
163Partial agenesis of the corpus callosum (HP:0001338)1.84459945
164Supraventricular arrhythmia (HP:0005115)1.84245799
165Microtia (HP:0008551)1.82358996
166Recurrent sinusitis (HP:0011108)1.81642426
167IgA deficiency (HP:0002720)1.81520828
168Chronic diarrhea (HP:0002028)1.81146411
169Intestinal fistula (HP:0100819)1.80433152
170Abnormality of the pericardium (HP:0001697)1.78862747
171Arthralgia (HP:0002829)1.78183869
172Abnormality of the nasal mucosa (HP:0000433)1.77638860
173Increased CSF protein (HP:0002922)1.77607947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK5.69470355
2TXK3.91331933
3RIPK43.73134394
4NME23.21970485
5CDC72.97730448
6MST42.75393666
7ERN12.69051990
8FES2.51799654
9MAP3K142.48688480
10INSRR2.45781908
11GRK12.40678129
12IRAK42.37557090
13MAP4K12.34190616
14CLK12.26173530
15BTK2.24422002
16EPHB12.09285971
17MAP2K32.04427070
18BLK2.03479753
19TAOK31.97901203
20MARK31.97003375
21ITK1.90371312
22MAP2K21.82113266
23MELK1.79726204
24PRPF4B1.77503651
25JAK11.71243110
26MKNK21.66085071
27STK101.63992054
28TESK21.60118880
29ZAK1.59995004
30TTN1.57773801
31ACVR1B1.57219280
32PINK11.56414047
33MAP3K131.51866234
34GRK61.51533582
35IKBKE1.47757017
36TAOK11.47693536
37TBK11.46964829
38ERBB31.45980400
39MAP3K111.39303152
40SGK21.37580050
41ADRBK21.37459017
42MAP3K31.36177090
43SGK31.36081131
44LYN1.32840249
45TRIB31.30064471
46MKNK11.24002161
47TSSK61.23874198
48PIM11.23489358
49CSK1.17097975
50PRKCH1.16374269
51SGK4941.12925558
52SGK2231.12925558
53TEC1.12503397
54STK161.10226196
55YES11.08046030
56JAK21.05669027
57MAP3K11.04663619
58FGFR41.03162212
59FGR1.01983405
60ZAP701.01947145
61MUSK1.01932428
62SMG11.01429258
63DYRK1B1.00867832
64KDR0.99422403
65MAP2K60.99369391
66KSR20.95015015
67LCK0.94750562
68MAPK70.91824831
69EPHA30.90673071
70VRK10.89307666
71CSF1R0.88210091
72PASK0.87590907
73PTK60.87075435
74CASK0.86861051
75JAK30.86707153
76CAMKK10.86647850
77CHUK0.85260570
78CDK80.84484185
79PRKD20.83570089
80PDK10.82933169
81SIK10.81863666
82STK40.80408512
83CDK30.79705032
84PKN10.79673135
85CCNB10.79321672
86SIK30.79263927
87PLK10.77377058
88TAOK20.77198605
89AURKB0.77123932
90MAPK120.74992762
91TYK20.74889578
92MAP3K70.72609827
93HIPK20.72203139
94CAMKK20.71785229
95ATR0.71126239
96FGFR30.69678203
97FYN0.68926066
98KIT0.67771746
99IKBKB0.67546331
100LRRK20.63722845
101WEE10.63346573
102ALK0.62319393
103SIK20.61795101
104STK240.61425123
105MAP3K120.60698593
106CDK190.60464945
107MAP3K50.58908373
108CHEK10.58702162
109CDK40.57669977
110TIE10.53975030
111RPS6KA60.53930861
112PDPK10.53199226
113BRD40.52784659
114TNK20.52399340
115STK380.52276996
116CDC42BPA0.51937105
117DYRK1A0.51510257
118IRAK30.51148498
119MAP3K100.51008960
120RPS6KC10.50031157
121RPS6KL10.50031157
122PLK30.49879066
123PIM20.48636055
124TTK0.48402316
125MYLK0.48147408
126MAPK110.47911812
127IRAK10.47662859
128PRKG20.47303554
129STK110.47009249
130PAK30.46778635
131SYK0.46026084
132MAPK80.45520066
133EPHA20.45492910
134PTK2B0.44007234
135MAPK90.43863701
136GRK70.43424722
137SGK10.43288694
138PNCK0.42356293
139ADRBK10.40060039
140EIF2AK20.39606829
141MARK20.39148574
142PRKCQ0.39136970
143BMX0.38072943
144TGFBR20.37777734
145MAPK40.36898193
146CDK20.36560921
147MAPKAPK20.35666805
148SRPK10.35575851
149HCK0.35536853
150RAF10.35337369
151CSNK2A10.34478284
152CDK120.31452096
153TESK10.31437057
154RET0.29514359
155MAP3K20.28997393
156BMPR20.26037141
157TYRO30.22440893

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.44124720
2Phototransduction_Homo sapiens_hsa047444.21105291
3Vitamin B6 metabolism_Homo sapiens_hsa007503.83832595
4Primary immunodeficiency_Homo sapiens_hsa053403.63567999
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.81682468
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.79004914
7Viral myocarditis_Homo sapiens_hsa054162.47730484
8Antigen processing and presentation_Homo sapiens_hsa046122.21850308
9Fanconi anemia pathway_Homo sapiens_hsa034602.12681231
10Staphylococcus aureus infection_Homo sapiens_hsa051502.12563169
11T cell receptor signaling pathway_Homo sapiens_hsa046602.11200045
12RNA polymerase_Homo sapiens_hsa030201.87210950
13Colorectal cancer_Homo sapiens_hsa052101.80546936
14Cell cycle_Homo sapiens_hsa041101.74150464
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71366461
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69639160
17Sphingolipid metabolism_Homo sapiens_hsa006001.63063933
18Tuberculosis_Homo sapiens_hsa051521.62952934
19Malaria_Homo sapiens_hsa051441.59272738
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57580387
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51683780
22Olfactory transduction_Homo sapiens_hsa047401.50537313
23Measles_Homo sapiens_hsa051621.50327401
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46490769
25DNA replication_Homo sapiens_hsa030301.45407707
26RNA degradation_Homo sapiens_hsa030181.44404863
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43286460
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42202342
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.41874344
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36133002
31Nucleotide excision repair_Homo sapiens_hsa034201.32905177
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.32254315
33Influenza A_Homo sapiens_hsa051641.28705881
34Spliceosome_Homo sapiens_hsa030401.25820396
35Hematopoietic cell lineage_Homo sapiens_hsa046401.25593530
36Base excision repair_Homo sapiens_hsa034101.24902916
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21560461
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20822084
39Dilated cardiomyopathy_Homo sapiens_hsa054141.20763148
40Mismatch repair_Homo sapiens_hsa034301.15472511
41TNF signaling pathway_Homo sapiens_hsa046681.13288353
42p53 signaling pathway_Homo sapiens_hsa041151.11069584
43VEGF signaling pathway_Homo sapiens_hsa043701.10962929
44Adherens junction_Homo sapiens_hsa045201.10507112
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.07675496
46Legionellosis_Homo sapiens_hsa051341.04686251
47RNA transport_Homo sapiens_hsa030131.01981177
48Purine metabolism_Homo sapiens_hsa002300.99744962
49Other glycan degradation_Homo sapiens_hsa005110.98055836
50African trypanosomiasis_Homo sapiens_hsa051430.97166384
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95929878
52Phagosome_Homo sapiens_hsa041450.95820924
53Acute myeloid leukemia_Homo sapiens_hsa052210.94061325
54Hepatitis C_Homo sapiens_hsa051600.93194342
55Shigellosis_Homo sapiens_hsa051310.91926266
56HTLV-I infection_Homo sapiens_hsa051660.91025600
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90082297
58Asthma_Homo sapiens_hsa053100.90041504
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84982960
60Endocytosis_Homo sapiens_hsa041440.84643604
61Hepatitis B_Homo sapiens_hsa051610.83724506
62Selenocompound metabolism_Homo sapiens_hsa004500.82871477
63Endometrial cancer_Homo sapiens_hsa052130.81390128
64B cell receptor signaling pathway_Homo sapiens_hsa046620.79559054
65Thyroid cancer_Homo sapiens_hsa052160.79397909
66FoxO signaling pathway_Homo sapiens_hsa040680.79148151
67Allograft rejection_Homo sapiens_hsa053300.76507876
68Pertussis_Homo sapiens_hsa051330.75098225
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72814271
70Homologous recombination_Homo sapiens_hsa034400.71953568
71Apoptosis_Homo sapiens_hsa042100.71379222
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70758347
73Pancreatic cancer_Homo sapiens_hsa052120.70315669
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.70059592
75Choline metabolism in cancer_Homo sapiens_hsa052310.69830974
76Prolactin signaling pathway_Homo sapiens_hsa049170.69701721
77Renal cell carcinoma_Homo sapiens_hsa052110.69358434
78Salmonella infection_Homo sapiens_hsa051320.67817872
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.67727343
80Regulation of autophagy_Homo sapiens_hsa041400.66425738
81Wnt signaling pathway_Homo sapiens_hsa043100.66174437
82Chemokine signaling pathway_Homo sapiens_hsa040620.66017980
83Leishmaniasis_Homo sapiens_hsa051400.64389851
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63985517
85Prostate cancer_Homo sapiens_hsa052150.63638770
86Rheumatoid arthritis_Homo sapiens_hsa053230.62226581
87Chronic myeloid leukemia_Homo sapiens_hsa052200.61143075
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60850876
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60300261
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60119046
91MAPK signaling pathway_Homo sapiens_hsa040100.59659132
92Oxytocin signaling pathway_Homo sapiens_hsa049210.59327676
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.58518130
94Cardiac muscle contraction_Homo sapiens_hsa042600.58376447
95Autoimmune thyroid disease_Homo sapiens_hsa053200.58207152
96Pyrimidine metabolism_Homo sapiens_hsa002400.57159541
97Small cell lung cancer_Homo sapiens_hsa052220.55357978
98Viral carcinogenesis_Homo sapiens_hsa052030.54829100
99Notch signaling pathway_Homo sapiens_hsa043300.52050974
100Epstein-Barr virus infection_Homo sapiens_hsa051690.50495619
101Insulin resistance_Homo sapiens_hsa049310.49883448
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49054779
103Morphine addiction_Homo sapiens_hsa050320.48933644
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.48499141
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48256772
106Taste transduction_Homo sapiens_hsa047420.48138194
107GnRH signaling pathway_Homo sapiens_hsa049120.47968890
108mTOR signaling pathway_Homo sapiens_hsa041500.47961670
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47585934
110Rap1 signaling pathway_Homo sapiens_hsa040150.47126562
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45535371
112Platelet activation_Homo sapiens_hsa046110.45517476
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45390597
114Ribosome_Homo sapiens_hsa030100.45123837
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41829737
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41296004
117Cholinergic synapse_Homo sapiens_hsa047250.40919672
118Ras signaling pathway_Homo sapiens_hsa040140.38289168
119Long-term potentiation_Homo sapiens_hsa047200.38191989
120mRNA surveillance pathway_Homo sapiens_hsa030150.37377187
121Fructose and mannose metabolism_Homo sapiens_hsa000510.36522714
122Proteasome_Homo sapiens_hsa030500.36344296
123ErbB signaling pathway_Homo sapiens_hsa040120.35694137
124Type I diabetes mellitus_Homo sapiens_hsa049400.35269298
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34590045
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.33828109
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33782719
128Folate biosynthesis_Homo sapiens_hsa007900.33766943
129Toxoplasmosis_Homo sapiens_hsa051450.32650930
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32582446
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32352612
132Lysosome_Homo sapiens_hsa041420.32201478
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32056844
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31057079
135HIF-1 signaling pathway_Homo sapiens_hsa040660.30948943
136Pathways in cancer_Homo sapiens_hsa052000.30946021
137Insulin signaling pathway_Homo sapiens_hsa049100.30934429
138Osteoclast differentiation_Homo sapiens_hsa043800.30056864
139Type II diabetes mellitus_Homo sapiens_hsa049300.29506196
140Non-small cell lung cancer_Homo sapiens_hsa052230.28532648
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28237469
142Renin secretion_Homo sapiens_hsa049240.27074661
143Gastric acid secretion_Homo sapiens_hsa049710.26475852
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26428155
145Herpes simplex infection_Homo sapiens_hsa051680.25878176
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25400788
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.24873786
148Inositol phosphate metabolism_Homo sapiens_hsa005620.24617737

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